Disposable blood sampling separation consumable and blood component separation method

Abstract

The invention relates to a disposable blood sampling separation consumable and a blood component separation method, and belongs to the technical field of blood component separation. The inferior blood sampling separation consumable comprises a vein puncture outfit, a leukocyte-depleting filter, a fourth flow stopping clip, a limiting clip and a plasma separation cup which are sequentially communicated and connected through a pipeline. The plasma separating cup is connected with a plasma bag through an input pipeline, and a sixth flow stopping clamp is arranged on the input pipeline. The pipeline between the fourth flow stopping clip and the limiting clip is communicated and connected with a blood cell bag, and a fifth flow stopping clip is arranged at an inlet of the blood cell bag. In the blood sampling process, blood components are directly separated, whole blood does not need to be transferred to a blood station, the labor intensity of medical workers is reduced, meanwhile, blood cross infection is avoided, and the blood management pressure of the blood station is also reduced.

Description

Technical Field

[0001] The present application belongs to the technical field of blood component separation, and specifically relates to disposable blood collection and separation consumables and a blood component separation method. Background Art

[0002] Blood includes plasma and red blood cells. The existing blood collection work, whether in a blood donation vehicle or a blood donation house, mostly collects whole blood. However, when transfusing a patient, the whole blood is not directly delivered. Instead, the whole blood is first transported to a blood station, where it is separated into plasma and red blood cells for transfusion.

[0003] The main reasons for not transfusing whole blood are as follows:

[0004] Improve treatment effect: Through component transfusion, the most appropriate blood components can be provided according to the specific needs of the patient. For example, anemic patients may only need red blood cells to increase oxygen transport capacity; while patients with coagulation disorders may need platelets or specific coagulation factors.

[0005] Reduce adverse reactions: Whole blood contains a variety of antigens, which increases the risk of immune reactions, such as fever, allergies, etc. The use of separated components can reduce unnecessary antigen input and reduce these risks.

[0006] Save resources: The blood of one donor can be divided into different components and used for the needs of multiple patients, thereby making more efficient use of limited blood resources.

[0007] Reduce complications: In some cases, excessive fluid volume may lead to circulatory overload, especially in patients with cardiac insufficiency or the elderly. Component transfusion can avoid this.

[0008] Extended shelf life: Different blood components have different optimal storage conditions and times. For example, red blood cells can be stored for a longer period of time under refrigeration, while platelets need to be stored at a specific temperature and have a shorter shelf life. After separating the blood, the most suitable storage conditions can be provided for each component to maintain its activity and functionality.

[0009] Reduced risk of infection: Although modern screening techniques have greatly reduced the risk of blood-borne diseases, apheresis can help reduce this risk further by reducing the total amount of blood received in each transfusion.

[0010] Furthermore, it is essential to separate the blood components of the collected whole blood. However, the existing method of separating the blood components after transporting the collected whole blood to the blood station is not only time-consuming and labor-intensive, but also increases the labor intensity of medical staff and increases the risk of cross-infection of blood. Summary of the invention

[0011] The technical problem to be solved by the present application is: to overcome the deficiencies of the prior art and provide a disposable blood collection and separation consumable and a blood component separation method. The present application directly separates the blood components during the blood collection process without the need to transport the whole blood to a blood station, thereby reducing the labor intensity of medical staff, while also avoiding cross-infection of blood and reducing the pressure on blood stations to manage blood.

[0012] The technical solution adopted by this application to solve the problems existing in the prior art is:

[0013] Disposable blood collection and separation consumables include a venous puncture device, a leukocyte removal filter, a fourth flow-stopping clamp, a limit clamp and a plasma separation cup which are sequentially connected through pipelines.

[0014] The plasma separation cup is connected with a plasma bag via an input pipeline, and a sixth flow-stopping clamp is arranged on the input pipeline.

[0015] The pipeline between the fourth flow-stopping clamp and the limiting clamp is connected with a blood cell bag, and the entrance of the blood cell bag is provided with a fifth flow-stopping clamp.

[0016] Preferably, a blood and blood component filter is connected in series between the leukocyte removal filter and the venipuncture device.

[0017] Preferably, a blood buffer bag is connected in series between the blood and blood component filter and the venipuncture device.

[0018] Preferably, the inlet end of the blood buffer bag is provided with a first flow-stopping clamp, and the outlet end of the blood buffer bag is provided with a folding tube and a second flow-stopping clamp in sequence.

[0019] Preferably, the blood buffer bag is filled with an anticoagulant.

[0020] Preferably, the liquid outlet end of the blood and blood component filter is connected to a pressure detector connector via a pipeline, and a third flow-stop clamp is provided on the pipeline.

[0021] Preferably, the blood cell belt is provided with a blood transfusion port.

[0022] A blood component separation method, based on the above-mentioned disposable blood collection and separation consumables, comprises the following steps:

[0023] S01. Open the first stop-flow clamp, the second stop-flow clamp, the fourth stop-flow clamp and the sixth stop-flow clamp in the disposable blood collection and separation consumables, and close the fifth stop-flow clamp.

[0024] S02. Install the disposable blood collection and separation consumables on the blood component separator.

[0025] S03. Insert the venous puncture device into the human vein, and the blood enters the blood buffer bag. Open the folding tube behind the blood buffer bag, start the blood component separator, and rotate the peristaltic pump forward. The blood in the blood buffer bag passes through the blood and blood component filter, flows through the leukocyte removal filter, and enters the plasma separation cup.

[0026] S04. The plasma separation cup rotates at high speed on the blood component separator, and the blood is separated into plasma in the plasma separation cup and enters the plasma bag through the input pipeline.

[0027] S05. After plasma separation is completed, the fourth stop-flow clamp is closed, the fifth stop-flow clamp is opened, the peristaltic pump is reversed, and the blood cells in the plasma separation cup are pumped into the blood cell bag. The plasma bag and the blood cell bag are labeled and put into storage.

[0028] Preferably, in step S02, the installation method of the disposable blood collection and separation consumables and the blood component separator is as follows: the limit card is installed on the peristaltic pump of the blood component separator, and the plasma separation cup is installed in the centrifugal well of the blood component separator.

[0029] Preferably, when the number of blood donors exceeds a threshold, the first stop-flow clamp, the fifth stop-flow clamp, the fourth stop-flow clamp and the sixth stop-flow clamp in the disposable blood collection and separation consumables are opened, and the second stop-flow clamp is closed.

[0030] The venous puncture device is inserted into the human vein, and the blood enters the blood buffer bag. After the whole blood is collected, the first stop clamp is closed and the puncture needle on the venous puncture device is heat-sealed.

[0031] After the blood component separator is idle, install the disposable blood collection and separation consumables on the blood component separator, close the fifth stop clamp, open the folding tube behind the blood buffer bag, and start the blood component separator.

[0032] Compared with the prior art, the present application has the following beneficial effects: blood components can be directly separated during the blood collection process without the need to transport the whole blood to a blood station, thereby reducing the labor intensity of medical staff, avoiding cross-infection of blood, and reducing the blood management pressure on blood stations.

[0033] When there are a large number of blood donors, blood can be collected first, and then the components of the whole blood can be separated later using disposable blood collection and separation consumables and a blood component separator, further improving the efficiency of medical staff's time utilization. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] The present application is further described below in conjunction with the accompanying drawings and embodiments.

[0035] Figure 1 This is a structural diagram of the disposable blood collection and separation consumables for this application.

[0036] In the figure: 1-blood cell bag, 2-plasma bag, 3-plasma separation cup, 4-blood buffer bag, 5-leukocyte removal filter, 6-blood and blood component filter, 7-venipuncture device, 8-first stop-flow clamp, 9-folding tube, 10-second stop-flow clamp, 11-third stop-flow clamp, 12-pressure monitor connector, 13-fourth stop-flow clamp, 14-blood transfusion socket, 15-fifth stop-flow clamp, 16-limit clamp, 17-input pipeline, 18-sixth stop-flow clamp. DETAILED DESCRIPTION

[0037] The disposable blood collection and separation consumables and the blood component separation method of the present application are further described in detail in conjunction with the accompanying drawings, but are not intended to limit the present application.

[0038] Disposable blood collection and separation consumables, made of Figure 1 As shown, it includes a venous puncture device 7, a leukocyte removal filter 5, a fourth flow-stopping clamp 13, a limiting clamp 16 and a plasma separation cup 3 which are sequentially connected through pipelines.

[0039] The plasma separation cup 3 is connected to the plasma bag 2 via an input pipeline 17 , and a sixth flow-stopping clamp 18 is provided on the input pipeline 17 .

[0040] The pipeline between the fourth flow-stopping clamp 13 and the limiting clamp 16 is connected to the blood cell bag 1 , and the inlet of the blood cell bag 1 is provided with a fifth flow-stopping clamp 15 .

[0041] A blood and blood component filter 6 is connected in series between the leukocyte removal filter 5 and the venous puncture device 7. The blood and blood component filter 6 can prevent larger particles or clots from entering the downstream processing equipment, thereby avoiding clogging of the leukocyte filter 5.

[0042] At the same time, the liquid outlet of the blood and blood component filter 6 is connected to a pressure detector connector 12 through a pipeline, and a third stopper clamp 11 is provided on the pipeline. The pressure detector connector 12 is connected to the pressure detector, and the third stopper clamp 11 is opened to detect the pressure at the liquid outlet of the blood and blood component filter 6, thereby determining whether the blood and blood component filter 6 is seriously clogged.

[0043] A blood buffer bag 4 is connected in series between the blood and blood component filter 6 and the venous puncture device 7. The inlet end of the blood buffer bag 4 is provided with a first stopper clamp 8, and the outlet end of the blood buffer bag 4 is provided with a folding tube 9 and a second stopper clamp 10 in sequence. The blood buffer bag 4 is filled with an anticoagulant. The blood buffer bag 4 can buffer blood, add anticoagulants, and temporarily store the collected blood.

[0044] The blood cell belt 1 is provided with a blood transfusion socket 14, and when blood transfusion is needed, it can be directly transfused through the blood transfusion socket 14. In this way, blood can be donated and transfused at the same time in an emergency state, thereby improving the efficiency and success rate of emergency rescue.

[0045] A method for separating blood components, comprising the following two situations:

[0046] The first method of blood separation when there are very few blood donors is as follows:

[0047] Open the first stop-flow clamp 8 , the second stop-flow clamp 10 , the third stop-flow clamp 11 , the fourth stop-flow clamp 13 and the sixth stop-flow clamp 18 in the disposable blood collection and separation consumables, and close the fifth stop-flow clamp 15 .

[0048] The disposable blood collection and separation consumables are installed on the blood component separator, which is a prior art. The installation method of the disposable blood collection and separation consumables and the blood component separator is as follows: the limit card 16 is installed on the peristaltic pump, and the plasma separation cup 3 is installed in the centrifugal well.

[0049] The venous puncture device 7 is inserted into the human vein, and the blood enters the blood buffer bag 4 and mixes with the anticoagulant inside the blood buffer bag 4. The folding tube 9 behind the blood buffer bag 4 is opened, the blood component separator is started, the peristaltic pump rotates forward, and the blood in the blood buffer bag 4 passes through the blood and blood component filter 6, flows through the leukocyte removal filter 5, and enters the plasma separation cup 3.

[0050] The plasma separation cup 3 rotates at high speed on the blood component separator, and the blood is separated into plasma in the plasma separation cup 3 and enters the plasma bag 2 through the input pipeline 17. The capacity of the plasma separation cup 3 is 350-500ml, which can accommodate all blood (an adult can donate up to 400ml of blood at a time). After the plasma separation is completed, the fourth stop clamp 13 is closed, the fifth stop clamp 15 is opened, the peristaltic pump is reversed, and the blood cells in the plasma separation cup 3 are pumped into the blood cell bag 1. The plasma bag 2 and the blood cell bag 1 are labeled and put into storage.

[0051] The plasma separation cup adopts the existing technology and refers to a plasma apheresis centrifugal separator with application number CN00248423.4.

[0052] The second method is as follows when the number of blood donors is slightly larger, that is, when the number of blood donors exceeds the threshold:

[0053] Open the first stop-flow clamp 8 , the fifth stop-flow clamp 15 , the third stop-flow clamp 11 , the fourth stop-flow clamp 13 and the sixth stop-flow clamp 18 in the disposable blood collection and separation consumables, and close the second stop-flow clamp 10 .

[0054] The venous puncture device 7 is inserted into the human vein, and the blood enters the blood buffer bag 4, which can store 400ml of whole blood. After the whole blood is collected, the first stop clamp 8 is closed, and the puncture needle on the venous puncture device 7 is heat-sealed, and the blood is separated when the number of blood donors decreases in the later period.

[0055] After the blood component separator is idle, the disposable blood collection and separation consumables are installed on the blood component separator, the fifth flow-stopping clamp 15 is closed, the folding tube 9 behind the blood buffer bag 4 is opened, and the blood component separator is started.

[0056] The peristaltic pump rotates forward, and the blood in the blood buffer bag 4 passes through the blood and blood component filter 6, flows through the leukocyte removal filter 5, and enters the plasma separation cup 3.

[0057] The plasma separation cup 3 rotates at high speed on the blood component separator, and the blood is separated into plasma in the plasma separation cup 3 and enters the plasma bag 2 through the input pipeline 17. The capacity of the plasma separation cup 3 is 350-500ml, which can accommodate all blood (an adult can donate up to 400ml of blood at a time). After the plasma separation is completed, the fourth stop clamp 13 is closed, the fifth stop clamp 15 is opened, the peristaltic pump is reversed, and the blood cells in the plasma separation cup 3 are pumped into the blood cell bag 1. The plasma bag 2 and the blood cell bag 1 are labeled and put into storage.

[0058] The threshold number of blood donors is determined according to the number of blood component separators installed in each blood donation vehicle or blood donation room, and the threshold number of blood donors is greater than or equal to the number of blood component separators.

[0059] The implementation methods of the present application are described in detail above in conjunction with the accompanying drawings, but the present application is not limited to the above implementation methods, and various changes can be made within the knowledge scope of ordinary technicians in the relevant technical field without departing from the purpose of the present application.

Claims

1. Disposable blood collection and separation consumables, characterized by: It comprises a venous puncture device (7), a leukocyte removal filter (5), a fourth flow-stopping clamp (13), a limiting clamp (16) and a plasma separation cup (3) which are sequentially connected through a pipeline; The plasma separation cup (3) is connected to the plasma bag (2) via an input pipeline (17), and a sixth flow-stopping clamp (18) is provided on the input pipeline (17); The pipeline between the fourth flow-stopping clamp (13) and the limiting clamp (16) is connected to the blood cell bag (1), and the entrance of the blood cell bag (1) is provided with a fifth flow-stopping clamp (15).

2. The disposable blood collection and separation consumable according to claim 1, characterized in that: A blood and blood component filter (6) is connected in series between the leukocyte removal filter (5) and the venous puncture device (7).

3. The disposable blood collection and separation consumable according to claim 2, characterized in that: A blood buffer bag (4) is connected in series between the blood and blood component filter (6) and the venous puncture device (7).

4. The disposable blood collection and separation consumable according to claim 3, characterized in that: The inlet end of the blood buffer bag (4) is provided with a first flow-stopping clamp (8), and the outlet end of the blood buffer bag (4) is provided with a folding tube (9) and a second flow-stopping clamp (10) in sequence.

5. The disposable blood collection and separation consumable according to claim 3 or 4, characterized in that: The blood buffer bag (4) is filled with an anticoagulant.

6. The disposable blood collection and separation consumable according to claim 2, 3 or 4, characterized in that: The liquid outlet end of the blood and blood component filter (6) is connected to a pressure detector connector (12) through a pipeline, and a third flow-stopping clamp (11) is provided on the pipeline.

7. The disposable blood collection and separation consumable according to any one of claims 1 to 4, characterized in that: The blood cell belt (1) is provided with a blood transfusion socket (14).

8. A method for separating blood components, based on the disposable blood collection and separation consumables according to claim 4, characterized in that: The following steps are involved: S01, opening the first stop-flow clamp (8), the second stop-flow clamp (10), the fourth stop-flow clamp (13) and the sixth stop-flow clamp (18) in the disposable blood collection and separation consumables, and closing the fifth stop-flow clamp (15); S02, installing disposable blood collection and separation consumables on the blood component separator; S03, inserting the venous puncture device (7) into a human vein, allowing blood to enter the blood buffer bag (4), opening the folding tube (9) behind the blood buffer bag (4), starting the blood component separator, and rotating the peristaltic pump forward. The blood in the blood buffer bag (4) passes through the blood and blood component filter (6), flows through the leukocyte removal filter (5), and enters the plasma separation cup (3); S04, the plasma separation cup (3) rotates at high speed on the blood component separator, and the blood is separated into plasma in the plasma separation cup (3), and enters the plasma bag (2) through the input pipeline (17); S05. After the plasma separation is completed, the fourth stop-flow clamp (13) is closed, the fifth stop-flow clamp (15) is opened, the peristaltic pump is reversed, and the blood cells in the plasma separation cup (3) are pumped into the blood cell bag (1). The plasma bag (2) and the blood cell bag (1) are labeled and put into storage.

9. A method for separating blood components according to claim 8, characterized in that: In step S02, the installation method of the disposable blood collection and separation consumables and the blood component separator is as follows: the limit card (16) is installed on the peristaltic pump of the blood component separator, and the plasma separation cup (3) is installed in the centrifugal well of the blood component separator.

10. A method for separating blood components according to claim 8 or 9, characterized in that: When the number of blood donors exceeds a threshold, the first stop-flow clamp (8), the fifth stop-flow clamp (15), the fourth stop-flow clamp (13) and the sixth stop-flow clamp (18) in the disposable blood collection and separation consumables are opened, and the second stop-flow clamp (10) is closed; The venous puncture device (7) is inserted into a human vein, and blood enters the blood buffer bag (4). After the whole blood is collected, the first stop-flow clamp (8) is closed, and the puncture needle on the venous puncture device (7) is heat-sealed; After the blood component separator is idle, the disposable blood collection and separation consumables are installed on the blood component separator, the fifth stop clamp (15) is closed, the folding tube (9) behind the blood buffer bag (4) is opened, and the blood component separator is started.

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