Impurity removal device and method for preparing rukotinib phosphate

Abstract

The invention provides an impurity removal device and method for preparing rukotinib phosphate. Relates to the technical field of rukotinib phosphate, in particular to an impurity removal device for rukotinib phosphate preparation and a method thereof.The impurity removal device for rukotinib phosphate preparation comprises supporting plates fixed to two bottom plates, a transverse rod is rotationally installed on the two supporting plates, the transverse rod is fixedly sleeved with two liquid containing bottles, and the upper ends and the lower ends of the liquid containing bottles are in a through opening state; a circular plate is arranged below the two liquid containing bottles, an adjusting rod is fixedly installed at the bottom of the circular plate, the circular plate is fixedly sleeved with annular filter cloth, the annular filter cloth is fixedly sleeved with an annular plate, and a plurality of connecting rods are fixedly installed on the inner wall of the annular plate. The impurity removal device and the impurity removal method for preparing the rukotinib phosphate, which are provided by the invention, have the advantages of convenience and simplicity in operation and capability of improving the filtering efficiency.

Description

Technical Field

[0001] The present invention relates to the technical field of ruxolitinib phosphate, and in particular to an impurity removal device and method for preparing ruxolitinib phosphate. Background Art

[0002] Ruxolitinib phosphate, also known as JAKV, is an anti-tumor drug that is mainly used to treat specific diseases, including blood system diseases such as myelofibrosis and polycythemia vera4. The drug exerts its anti-tumor and immunomodulatory effects by inhibiting the activity of Janus kinase 1 and Janus kinase 2 (JAK1 / JAK2). During the production process of ruxolitinib phosphate solution, people generally use the impurity removal device for ruxolitinib phosphate preparation to remove impurities.

[0003] The existing impurity removal device for preparing ruxolitinib phosphate generally filters the water-insoluble solid impurities in the ruxolitinib phosphate solution through a filter cloth of fixed size. However, since the size of the filter cloth for filtering the ruxolitinib phosphate solution is fixed, the water-insoluble solid impurities will appear after the filter cloth has been used for a period of time, blocking the filter holes on the filter cloth, resulting in the need to remove the filter cloth for replacement at regular intervals. The process is relatively cumbersome and affects work efficiency.

[0004] Therefore, it is necessary to provide an impurity removal device and method for preparing ruxolitinib phosphate to solve the above technical problems. Summary of the invention

[0005] The technical problem solved by the present invention is to provide an impurity removal device and method for preparing ruxolitinib phosphate, which are convenient and simple to operate and can improve filtering efficiency.

[0006] In order to solve the above technical problems, the present invention provides an impurity removal device and method for preparing ruxolitinib phosphate, comprising a support plate fixed on two bottom plates, a cross bar rotatably mounted on the two support plates, two liquid bottles fixedly sleeved on the cross bar, and the upper and lower ends of the liquid bottles are in a through-opening state, a circular plate is arranged below the two liquid bottles, an adjusting rod is fixedly mounted on the bottom of the circular plate, an annular filter cloth is fixedly sleeved on the circular plate, an annular plate is fixedly sleeved on the annular filter cloth, a plurality of connecting rods are fixedly mounted on the inner wall of the annular plate, and the plurality of connecting rods are fixedly connected to the outer wall of the circular plate, and the plurality of connecting rods are located on the annular filter. Below the cloth, an annular cavity is opened in the annular plate, an annular groove is opened on the top inner wall of the annular cavity, a fixing plate is fixedly installed on the two liquid bottles, a vertical rod is slidably installed on the two fixing plates, and the bottom ends of the two vertical rods extend into the two annular cavities and are fixedly installed with pulling plates, respectively, and a hanging plate is fixedly installed on the top ends of the two vertical rods, a first circular plate is fixedly sleeved on the two vertical rods, a tension spring is movably sleeved on the two vertical rods, and the top ends of the two tension springs are fixedly connected to the two fixing plates, and the bottom ends of the two tension springs are fixedly connected to the two first circular plates.

[0007] Preferably, a direction indicator plate is fixedly mounted on the adjusting rod.

[0008] Preferably, the movable sleeve on the adjusting rod is provided with a protective tube, and the protective tube is fixedly connected to the circular plate.

[0009] Preferably, a plurality of rolling balls are rotatably mounted on the top of the two pulling plates, and the plurality of rolling balls are in contact with the top inner walls of the two annular cavities respectively.

[0010] Preferably, a protective heating cover is fixedly mounted on the two liquid bottles, and the bottom and top of the protective heating cover are both conical, and the top and bottom of the protective heating cover are both in an open state, a stepper motor is fixedly mounted inside the protective heating cover, a cleaning brush is arranged below the stepper motor, a through hole is provided on the cleaning brush, a rotating rod is fixedly mounted on the output shaft of the stepper motor, and the rotating rod passes through the through hole and is movably connected to the inner wall of the through hole, two limit grooves are provided on the inner wall of the through hole, two limit rods are fixedly mounted on the rotating rod, and the two limit rods are respectively located in the two limit grooves and are respectively slidably connected to the two limit grooves.

[0011] Preferably, a second circular plate is fixedly mounted on the rotating rod, a force spring is provided on the movable sleeve of the rotating rod, and the top end of the force spring is fixedly connected to the second circular plate, and the bottom end of the force spring is fixedly connected to the cleaning brush.

[0012] Preferably, a transverse plate is fixedly installed in the protective heating cover, two sliding rods are slidably installed on the transverse plate, sealing baffles are fixedly installed on the top ends of the two sliding rods, and limiting plates are fixedly installed on the bottom ends of the sliding rods.

[0013] Preferably, the surfaces of the tension spring and the force spring are both tin-plated.

[0014] The present invention also provides a method for using an impurity removal device for preparing ruxolitinib phosphate, comprising the following steps:

[0015] S1: pouring the ruxolitinib phosphate solution into a liquid bottle, and filtering the water-insoluble impurities in the ruxolitinib phosphate solution through a ring-shaped filter cloth;

[0016] S2: rotating the adjusting rod to rotate the portion of the annular filter cloth whose filter holes are blocked to a state separated from the liquid bottle, and at the same time rotating the portion of the annular filter cloth whose filter holes are intact to a state in contact with the liquid bottle to continue filtering the ruxolitinib phosphate solution;

[0017] S3: The two liquid bottles and the protective heating cover are rotated from the original top-up state to the bottom state, so that the sealing baffle moves downward and separates from the protective heating cover to open the protective heating cover;

[0018] S4: Drying the annular filter cloth by starting the protective heating cover;

[0019] S5: The cleaning brush is driven to rotate by the stepper motor to clean the annular filter cloth that blocks the filter holes, thereby completing the cleaning of the annular filter cloth.

[0020] Compared with the related art, the impurity removal device and method for preparing ruxolitinib phosphate provided by the present invention have the following beneficial effects:

[0021] The invention provides an impurity removal device for preparing ruxolitinib phosphate and a method thereof. A ruxolitinib phosphate solution is poured into a liquid-filling bottle, water-insoluble impurities in the ruxolitinib phosphate solution are filtered through an annular filter cloth, an adjusting rod is rotated at a certain angle to rotate a portion of the annular filter cloth whose filter holes are blocked to a state separated from the liquid-filling bottle, and at the same time, a portion of the annular filter cloth whose filter holes are intact is rotated to a state contacting with the liquid-filling bottle to continue filtering the ruxolitinib phosphate solution, so that people no longer need to spend time to disassemble and install the filter cloth, greatly improving work efficiency; two liquid-filling bottles and a protective heating cover are rotated from an original top-up state to a downward state through angle rotation, a sealing baffle moves downward to separate from the protective heating cover, and the protective heating cover is opened; the annular filter cloth is dried by starting the protective heating cover; a rotation angle on a stepping motor is set so that the stepping motor always keeps rotating for / cycles, and the forward and reverse reciprocating rotation in the rotation / cycles drives a cleaning brush to rotate to clean the annular filter cloth whose filter holes are blocked, so that the cleaning of the annular filter cloth is completed, and it is convenient for people to reuse the annular filter cloth. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 A schematic diagram of the main structure of the impurity removal device for preparing ruxolitinib phosphate provided by the present invention;

[0023] Figure 2 for Figure 1 An enlarged schematic diagram of section A is shown;

[0024] Figure 3 for Figure 1 An enlarged schematic diagram of portion B is shown;

[0025] Figure 4 for Figure 3 An enlarged schematic diagram of section C is shown;

[0026] Figure 5 for Figure 1 An enlarged schematic diagram of section D is shown;

[0027] Figure 6 for Figure 1 The assembly diagram of the circular plate, the annular filter cloth and the connecting rod shown;

[0028] Figure 7 for Figure 1 A three-dimensional image of the cleaning brush shown;

[0029] Figure 8 This is a front view of the impurity removal device for preparing ruxolitinib phosphate provided by the present invention.

[0030] Numbers in the figure: 1. bottom plate; 2. support plate; 3. cross bar; 4. liquid bottle; 5. protective heating cover; 6. fixed plate; 7. vertical rod; 8. first circular plate; 9. tension spring; 10. hanging plate; 11. annular plate; 12. circular plate; 13. annular filter cloth; 14. connecting rod; 15. pulling plate; 16. rolling ball; 17. annular groove; 18. stepping motor; 19. second circular plate; 20. cleaning brush; 21. sliding rod; 22. cross plate; 23. sealing baffle; 24. limit plate; 25. force spring; 26. limit groove; 27. rotating rod; 28. limit rod; 29. ​​protective tube; 30. adjustment rod; 31. direction indicator plate. DETAILED DESCRIPTION

[0031] The present invention will be further described below in conjunction with the accompanying drawings and implementation modes.

[0032] Please refer to Figure 1-Figure 8In an embodiment of the present invention, the impurity removal device for preparing ruxolitinib phosphate includes a support plate 2 fixed on two bottom plates 1, a cross bar 3 is rotatably mounted on the two support plates 2, two liquid bottles 4 are fixedly sleeved on the cross bar 3, and the upper and lower ends of the liquid bottles 4 are in a through-opening state, a circular plate 12 is arranged below the two liquid bottles 4, an adjusting rod 30 is fixedly mounted on the bottom of the circular plate 12, and a direction indicating plate 31 is fixedly mounted on the adjusting rod 30 to facilitate people to watch the rotation angle of the adjusting rod 30, and an annular filter cloth 13 is fixedly sleeved on the circular plate 12, and the ruxolitinib phosphate is filtered by the annular filter cloth 13. In order to filter the water-insoluble impurities in the ketidine solution, an annular plate 11 is fixedly sleeved on the annular filter cloth 13, and a plurality of connecting rods 14 are fixedly installed on the inner wall of the annular plate 11, and the plurality of connecting rods 14 are fixedly connected to the outer wall of the circular plate 12, and the plurality of connecting rods 14 are located below the annular filter cloth 13. An annular cavity is provided in the annular plate 11. In order to reduce the friction between the pulling plate 15 and the annular cavity and make the pulling plate 15 move more stably in the annular cavity, a plurality of rolling balls 16 are rollingly installed on the top of the two pulling plates 15, and a plurality of rolling balls 16 are rollingly installed on the top of the two pulling plates 15. The movable round ball 16 is in contact with the top inner wall of the two annular cavities respectively, and an annular groove 17 is provided on the top inner wall of the annular cavity. The two liquid bottles 4 are respectively fixedly installed with a fixed plate 6, and the two fixed plates 6 are respectively slidably installed with a vertical rod 7, and the bottom ends of the two vertical rods 7 extend into the two annular cavities respectively and are respectively fixedly installed with a pulling plate 15, and the top ends of the two vertical rods 7 are respectively fixedly installed with a hanging plate 10, and the two vertical rods 7 are respectively fixedly sleeved with a first circular plate 8, and the two vertical rods 7 are respectively movably sleeved with a tension spring 9, and the top ends of the two tension springs 9 are respectively in contact with the two fixed The fixed plate 6 is fixedly connected, and the bottom ends of the two tension springs 9 are respectively fixedly connected to the two first circular plates 8. The circular plate 12 is driven to rotate by the adjusting rod 30, and the rotation of the circular plate 12 drives the connecting rod 14 to rotate, and the rotation of the connecting rod 14 drives the annular filter cloth 13 to rotate, thereby rotating the part of the annular filter cloth 13 whose filter holes have been blocked to a separated state from the liquid bottle 4, and at the same time, rotating the part of the annular filter cloth 13 with intact filter holes to a state of contact with the liquid bottle 4 to continue filtering the ruxolitinib phosphate solution, so that people no longer need to spend time disassembling and installing the filter cloth, which greatly improves work efficiency.

[0033] In order to protect the adjusting rod 30 and the direction indicating plate 31 and prevent the ruxolitinib phosphate liquid from flowing onto the adjusting rod 30 and the direction indicating plate 31 to cause unnecessary trouble, a protective tube 29 is movably sleeved on the adjusting rod 30 and the direction indicating plate 31 , and the protective tube 29 is fixedly connected to the circular plate 12 .

[0034] In order to clean the annular filter cloth 13 that is blocked by the filter hole, complete the cleaning of the annular filter cloth 13, and facilitate people to reuse the annular filter cloth 13, a protective heating cover 5 is fixedly installed on the two liquid bottles 4, and the bottom and top of the protective heating cover 5 are both conical, and the top and bottom of the protective heating cover 5 are both in an open state. A stepper motor 18 is fixedly installed in the protective heating cover 5, and a cleaning brush 20 is arranged below the stepper motor 18, and a through hole is opened on the cleaning brush 20. A rotating rod 27 is fixedly installed on the output shaft of the stepper motor 18, and the rotating rod 27 passes through the through hole and is movably connected to the inner wall of the through hole, and a through hole is opened on the inner wall of the through hole. Two limit slots 26 and two limit rods 28 are fixedly installed on the rotating rod 27, and the two limit rods 28 are respectively located in the two limit slots 26 and are respectively slidably connected to the two limit slots 26. By setting the rotation angle on the stepper motor 18, the stepper motor 18 always keeps rotating only 1 / 4 cycle, and rotates back and forth in the 1 / 4 cycle. The rotation of the stepper motor 18 drives the rotating rod 27 to rotate, and the rotation of the rotating rod 27 drives the limit rod 28 to rotate. The rotation of the limit rod 28 drives the cleaning brush 20 to rotate to clean the annular filter cloth 13 that blocks the filter holes, and the cleaned impurities fall onto the sealing baffle 23 under the action of gravity.

[0035] In order to ensure that the bristles on the cleaning brush 20 are always in close contact with the annular filter cloth 13, and thus to clean the annular filter cloth 13 more thoroughly, a second circular plate 19 is fixedly mounted on the rotating rod 27, and a force spring 25 is movablely sleeved on the rotating rod 27. In order to increase the service life of the tension spring 9 and the force spring 25, the surfaces of the tension spring 9 and the force spring 25 are tin-plated, and the top end of the force spring 25 is fixedly connected to the second circular plate 19, and the bottom end of the force spring 25 is fixedly connected to the cleaning brush 20.

[0036] In order to block the opening at the top of the protective heating cover 5 when people use the device and prevent external dust from falling into the protective heating cover 5 and adhering to the annular filter cloth 13, thereby affecting the service life of the annular filter cloth 13, a horizontal plate 22 is fixedly installed in the protective heating cover 5, and two sliding rods 21 are slidably installed on the horizontal plate 22. Sealing baffles 23 are fixedly installed on the top ends of the two sliding rods 21, and limiting plates 24 are fixedly installed on the bottom ends of the sliding rods 21.

[0037] The working principle of the impurity removal device for preparing ruxolitinib phosphate provided by the present invention is as follows: in the initial state, the tension spring 9 is in a tensioned state, and the force spring 25 is in a compressed state. The tension spring 9 pulls the annular plate 11 to always be subjected to an upward tension, so that the annular filter cloth 13 is always in close contact with the opening at the bottom of the liquid-filling bottle 4 without being affected by other external forces. When the ruxolitinib phosphate solution needs to be filtered, the ruxolitinib phosphate solution is first poured into the liquid-filling bottle 4, and the ruxolitinib phosphate solution contacts the annular filter cloth 13 under the action of gravity, and the annular filter cloth 13 is filtered through the annular filter cloth 13. The cloth 13 filters the water-insoluble impurities in the ruxolitinib phosphate solution. When the water-insoluble solid impurities in the annular filter cloth 13 are used for a period of time to block the filter holes on the annular filter cloth 13, the adjusting rod 30 is rotated at a certain angle, the adjusting rod 30 rotates to drive the circular plate 12 to rotate, the circular plate 12 rotates to drive the connecting rod 14 to rotate, and the connecting rod 14 rotates to drive the annular filter cloth 13 to rotate, thereby rotating the part of the annular filter cloth 13 with the filter holes blocked to the separated state of the liquid bottle 4, and at the same time, the part of the annular filter cloth 13 with the filter holes intact is rotated to the state of contacting with the liquid bottle 4 to filter the ruxolitinib phosphate. The solution continues to be filtered, so that people no longer need to spend time disassembling and installing the filter cloth, which greatly improves work efficiency. When the device completes filtering the ruxolitinib phosphate solution and there is no more ruxolitinib phosphate solution in the liquid-filling bottle 4, the two liquid-filling bottles 4 are rotated 180 degrees, so that the two liquid-filling bottles 4 and the protective heating cover 5 are rotated from the original top-up state to the downward state. At this time, under the action of gravity, the sealing baffle 23 moves downward and separates from the protective heating cover 5, and then the protective heating cover 5 is opened, and then the protective heating cover 5 is started to increase the temperature around the annular filter cloth 13, and then the annular filter cloth 13 Drying, start the stepper motor 18, and by setting the rotation angle of the stepper motor 18, make the stepper motor 18 always keep rotating only 1 / 4 cycle, and rotate back and forth in the 1 / 4 cycle. The rotation of the stepper motor 18 drives the rotating rod 27 to rotate, and the rotation of the rotating rod 27 drives the limiting rod 28 to rotate. The rotation of the limiting rod 28 drives the cleaning brush 20 to rotate to clean the annular filter cloth 13 that blocks the filter hole. The cleaned impurities fall onto the sealing baffle 23 under the action of gravity, completing the cleaning of the annular filter cloth 13, making it convenient for people to use the annular filter cloth 13 again.

[0038] Compared with the related art, the impurity removal device for preparing ruxolitinib phosphate provided by the present invention has the following beneficial effects: the ruxolitinib phosphate solution is poured into the liquid-filling bottle 4, and the water-insoluble impurities in the ruxolitinib phosphate solution are filtered through the annular filter cloth 13, and the part of the annular filter cloth 13 with the filter holes blocked is rotated to the separated state of the liquid-filling bottle 4 by rotating the adjusting rod 30 at a certain angle, and at the same time, the part of the annular filter cloth 13 with the filter holes intact is rotated to the contact state with the liquid-filling bottle 4 to continue filtering the ruxolitinib phosphate solution, so that people no longer need to spend time to disassemble and install the filter cloth, which greatly improves the work efficiency. By rotating 180°, the two liquid bottles 4 and the protective heating cover 5 are rotated from the original top-up state to the downward state, and the sealing baffle 23 moves downward and separates from the protective heating cover 5 to open the protective heating cover 5. The annular filter cloth 13 is dried by starting the protective heating cover 5, and the rotation angle of the stepper motor 18 is set so that the stepper motor 18 always rotates only 1 / 4 cycle, and the reciprocating rotation back and forth in the 1 / 4 cycle drives the cleaning brush 20 to rotate to clean the annular filter cloth 13 blocked by the filter hole, thereby completing the cleaning of the annular filter cloth 13, making it convenient for people to reuse the annular filter cloth 13.

[0039] The present invention also provides a method for using an impurity removal device for preparing ruxolitinib phosphate, comprising the following steps:

[0040] S1: pouring the ruxolitinib phosphate solution into the liquid-filling bottle 4, and filtering the water-insoluble impurities in the ruxolitinib phosphate solution through the annular filter cloth 13;

[0041] S2: rotating the adjusting rod 30 to rotate the portion of the annular filter cloth 13 with blocked filter holes to a state separated from the liquid bottle 4, and at the same time rotating the portion of the annular filter cloth 13 with intact filter holes to a state in contact with the liquid bottle 4 to continue filtering the ruxolitinib phosphate solution;

[0042] S3: The two liquid bottles 4 and the protective heating cover 5 are rotated 180° from the original top-up state to the bottom state, so that the sealing baffle 23 moves downward and separates from the protective heating cover 5 to open the protective heating cover 5;

[0043] S4: Drying the annular filter cloth 13 by starting the protective heating cover 5;

[0044] S5: The cleaning brush 20 is driven to rotate by the stepping motor 18 to clean the annular filter cloth 13 whose filter holes are blocked, thereby completing the cleaning of the annular filter cloth 13.

[0045] The above are only embodiments of the present invention, and are not intended to limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made using the contents of the present invention specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. An impurity removal device for preparing ruxolitinib phosphate, comprising a support plate fixed on two bottom plates, characterized in that; A cross bar is rotatably mounted on the two support plates, two liquid bottles are fixedly sleeved on the cross bar, and the upper and lower ends of the liquid bottles are in a through-opening state, a circular plate is arranged below the two liquid bottles, an adjusting rod is fixedly mounted on the bottom of the circular plate, an annular filter cloth is fixedly sleeved on the circular plate, an annular plate is fixedly sleeved on the annular filter cloth, a plurality of connecting rods are fixedly mounted on the inner wall of the annular plate, and the plurality of connecting rods are fixedly connected to the outer wall of the circular plate, and the plurality of connecting rods are located below the annular filter cloth, an annular cavity is opened in the annular plate, and the annular cavity An annular groove is provided on the top inner wall of the cavity, and a fixing plate is fixedly installed on the two liquid bottles, and a vertical rod is slidably installed on the two fixing plates, and the bottom ends of the two vertical rods extend into the two annular cavities and are fixedly installed with pulling plates, respectively. A hanging plate is fixedly installed on the top ends of the two vertical rods, and a first circular plate is fixedly sleeved on the two vertical rods, and a tension spring is movably sleeved on the two vertical rods, and the top ends of the two tension springs are fixedly connected to the two fixing plates, and the bottom ends of the two tension springs are fixedly connected to the two first circular plates, respectively.

2. The impurity removal device for preparing ruxolitinib phosphate according to claim 1, characterized in that: A direction indicating plate is fixedly mounted on the adjusting rod.

3. The impurity removal device for preparing ruxolitinib phosphate according to claim 2, characterized in that: The movable sleeve on the adjusting rod is provided with a protective tube, and the protective tube is fixedly connected to the circular plate.

4. The impurity removal device for preparing ruxolitinib phosphate according to claim 3, characterized in that: A plurality of rolling balls are rotatably mounted on the tops of the two pulling plates, and the plurality of rolling balls are in contact with the top inner walls of the two annular cavities respectively.

5. The impurity removal device for preparing ruxolitinib phosphate according to claim 4, characterized in that: A protective heating cover is fixedly installed on the two liquid bottles, and the bottom and top of the protective heating cover are both conical, and the top and bottom of the protective heating cover are both in an open state. A stepper motor is fixedly installed in the protective heating cover, and a cleaning brush is arranged below the stepper motor, and a through hole is opened on the cleaning brush. A rotating rod is fixedly installed on the output shaft of the stepper motor, and the rotating rod passes through the through hole and is movably connected to the inner wall of the through hole. Two limit grooves are opened on the inner wall of the through hole, and two limit rods are fixedly installed on the rotating rod, and the two limit rods are respectively located in the two limit grooves and are respectively slidably connected to the two limit grooves.

6. The impurity removal device for preparing ruxolitinib phosphate according to claim 5, characterized in that: A second circular plate is fixedly mounted on the rotating rod, a force spring is provided on the movable sleeve of the rotating rod, and the top end of the force spring is fixedly connected to the second circular plate, and the bottom end of the force spring is fixedly connected to the cleaning brush.

7. The impurity removal device for preparing ruxolitinib phosphate according to claim 6, characterized in that: A transverse plate is fixedly installed in the protective heating cover, and two sliding rods are slidably installed on the transverse plate. Sealing baffles are fixedly installed on the top ends of the two sliding rods, and limiting plates are fixedly installed on the bottom ends of the sliding rods.

8. The impurity removal device for preparing ruxolitinib phosphate according to claim 6, characterized in that: The surfaces of the tension spring and the force spring are both tin-plated.

9. A method for using an impurity removal device for preparing ruxolitinib phosphate, characterized in that: The impurity removal device for preparing ruxolitinib phosphate according to any one of claims 1 to 8 is used, comprising the following steps: S1: pouring the ruxolitinib phosphate solution into a liquid bottle, and filtering the water-insoluble impurities in the ruxolitinib phosphate solution through a ring-shaped filter cloth; S2: rotating the adjusting rod to rotate the annular filter cloth portion whose filter holes are blocked to a state separated from the liquid bottle, and at the same time rotating the annular filter cloth portion whose filter holes are intact to a state contacting with the liquid bottle to continue filtering the ruxolitinib phosphate solution; S3: The two liquid bottles and the protective heating cover are rotated from the original top-up state to the bottom state, so that the sealing baffle moves downward and separates from the protective heating cover to open the protective heating cover; S4: Drying the annular filter cloth by starting the protective heating cover; S5: The cleaning brush is driven to rotate by the stepper motor to clean the annular filter cloth that blocks the filter holes, thereby completing the cleaning of the annular filter cloth.

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