Veterinary drug residue detection method and system based on spectrum technology

Abstract

The invention relates to the field of residue detection, in particular to a veterinary drug residue detection method and system based on a spectrum technology, and the method comprises the following steps: obtaining the relative concentration and predicted concentration of metabolic ions in an experimental sample; fitting the relative concentrations of the metabolic ions in the plurality of experimental samples to obtain the fitting concentration of the current experimental sample; calculating an abnormal index of metabolic ions in the current experimental sample; calculating the pollution degree of the current experimental sample, wherein the pollution degree represents the difference degree between the corresponding experimental sample and the historical experimental sample; and obtaining the optimal concentration of the metabolic ions of the current experimental sample according to the concentration function of the metabolic ions. According to the method, the metabolic ions of the veterinary drug in each experimental sample can be effectively distinguished by utilizing the ion coding list, the influence of the metabolic ions is fully considered when the residual quantity of the veterinary drug in the animal body is calculated, and the accuracy of the calculation result of the residual quantity of the veterinary drug is improved.

Description

Technical Field

[0001] The invention relates to the field of residue detection, and in particular to a veterinary drug residue detection method and system based on spectroscopy technology. Background Art

[0002] In modern animal husbandry, the use of veterinary drugs plays an important role in preventing and treating animal diseases. However, if the veterinary drug residues in meat products exceed the standard, it will pose a potential threat to the health of consumers, and accurate detection of veterinary drug residues in animals is required. Veterinary drug residues refer to the residues of the parent drug or its metabolites, including veterinary drug-related impurities, that accumulate or remain in the bodies of livestock and poultry or products (such as eggs, dairy products, meat products, etc.) after drug use. The commonly used veterinary drug residue detection method is to use gas chromatography-mass spectrometry to obtain the corresponding mass spectrum of the test sample, and obtain the veterinary drug residue based on the ratio of the ion content of the test sample to the ion content of the veterinary drug sample.

[0003] A Chinese patent with announcement number CN118858198B discloses a veterinary drug residue detection method and system based on spectral technology. The method is: by analyzing the spectral features in the spectral data, the representativeness of the chemical bond content in the sample represented by the characteristic peak points in the spectral data; analyzing the difference in the characteristic peaks of the chemical bonds in the samples after veterinary drug intake and the samples after historical veterinary drug intake, the difficulty of obtaining the chemical bonds is obtained; analyzing the time series change characteristics between the samples after historical veterinary drug intake, the extent to which the chemical bonds are affected by the animal's own metabolic capacity is obtained; then, according to the difficulty of obtaining the chemical bonds and the extent to which the chemical bonds are affected by the animal's own metabolic capacity, the characteristic peaks of the chemical bonds are cleaned; based on the characteristic peaks of the cleaned chemical bonds, the relative concentration of the elements corresponding to the chemical bonds is determined.

[0004] Due to the metabolic properties of animals themselves, veterinary drugs will be decomposed into related metabolites, that is, residual drugs exist in the animal body in two forms: parent drug and metabolites. However, the existing veterinary drug detection methods mainly detect the content of parent drug and ignore the content of metabolites, resulting in poor accuracy of veterinary drug residue detection results. Summary of the invention

[0005] In order to solve the problem in the prior art that metabolites are not considered when detecting the residual content of veterinary drugs, resulting in low accuracy of the detection results, the present invention provides a veterinary drug residue detection method and system based on spectral technology.

[0006] In the first aspect, the present invention provides a veterinary drug residue detection method based on spectroscopy technology, which adopts the following technical scheme: Acquire experimental samples at different times to obtain multiple experimental samples, obtain the relative concentration and predicted concentration of metabolic ions in the experimental samples; fit the relative concentration of metabolic ions in multiple experimental samples to obtain the fitted concentration of the current experimental sample; calculate the abnormal index of metabolic ions in the current experimental sample, and the abnormal index is positively correlated with the absolute value of the difference between the relative concentration and the fitted concentration; calculate the contamination degree of the current experimental sample, and the contamination degree represents the degree of difference between the corresponding experimental sample and the historical experimental sample; obtain the optimal concentration of metabolic ions of the current experimental sample according to the concentration function of metabolic ions, and the expression of the concentration function is:

[0007] In the formula, represents the optimal concentration of the hth related metabolic ion in the current experimental sample, represents the predicted concentration of the hth related metabolic ion in the current experimental sample, represents the relative concentration of the hth related metabolic ion in the current experimental sample, W represents the contamination degree of the current experimental sample, Indicates The contamination degree of historical experimental samples is m, and m represents the total number of historical experimental samples.

[0008] The optimal concentration of metabolic ions of the experimental sample is obtained according to the concentration function. The influence of metabolic ions is fully considered when calculating the veterinary drug residues in animals, which provides a theoretical basis for calculating the veterinary drug residues and further improves the accuracy of calculating the veterinary drug residues.

[0009] Preferably, the method for obtaining metabolic ions is: obtaining veterinary drug samples and control samples, constructing a coding list of corresponding ions for the veterinary drug samples, the control samples and the experimental samples, wherein the coding list consists of ion codes; obtaining the coding list of metabolic ions, and obtaining corresponding metabolic ions according to the coding list; The expression of the metabolic ion code list is:

[0010] In the formula, Represents the coding list of veterinary drug metabolic ions for the i-th experimental sample; represents the coding list of all ions in the i-th experimental sample; D represents the coding list of all ions in the control group sample; S represents the coding list of all ions in the veterinary drug sample.

[0011] The use of ion coding can effectively distinguish the metabolic ions in each experimental sample, thereby improving the accuracy of veterinary drug residue levels.

[0012] Preferably, the abnormal index expression of metabolic ions is:

[0013] In the formula, represents the abnormal index of the metabolic ions related to the hth veterinary drug in the i-th experimental sample; represents the relative concentration of the metabolite ion related to the hth veterinary drug in the i-th experimental sample; Represents the fitted concentration of the hth veterinary drug-related metabolite ion in the ith experimental sample.

[0014] Preferably, the abnormal index expression of metabolic ions is:

[0015] In the formula, represents the abnormal index of the metabolic ions related to the hth veterinary drug in the i-th experimental sample; represents the relative concentration of the metabolite ion related to the hth veterinary drug in the i-th experimental sample; Represents the fitted concentration of the hth veterinary drug-related metabolite ion in the ith experimental sample.

[0016] The anomaly index is used to facilitate the assessment of the degree of deviation of the relative concentrations of corresponding metabolic ions obtained by gas chromatography-mass spectrometry.

[0017] Preferably, the expression of pollution degree is:

[0018] In the formula, represents the contamination degree of the i-th experimental sample, represents the abnormal index of the hth veterinary drug-related metabolic ion in the ith experimental sample, n represents the total number of categories of veterinary drug-related metabolic ions in the ith experimental sample, represents the average value of the abnormal index of the metabolic ions related to the hth veterinary drug in other experimental samples except the i-th experimental sample, represents the standard deviation of the abnormal index of the h-th veterinary drug-related metabolic ions of other experimental samples except the i-th experimental sample, and norm represents the normalization function.

[0019] The degree of contamination of the experimental samples can be used to understand the extent to which the corresponding experimental samples may be affected by pollutants.

[0020] Preferably, the method for obtaining the predicted concentration is: taking the ratio of the contamination degree of the current experimental sample to the sum of the contamination degrees of all experimental samples as the weight coefficient of the current experimental sample, taking the inverse of the weight coefficient as the smoothing coefficient in the exponential smoothing algorithm, and using the exponential smoothing algorithm to calculate the predicted concentration of the current experimental sample.

[0021] By using the inverse of the weight coefficient as the smoothing coefficient, when the predicted concentration of the current experimental sample is calculated using the exponential smoothing algorithm, the influence of the experimental samples with a higher degree of pollution is weakened, further improving the accuracy of the predicted concentration results.

[0022] Preferably, the method for fitting the relative concentrations of metabolic ions in multiple experimental samples to obtain the fitted concentration of the current experimental sample is: constructing a rectangular coordinate system with time as the X-axis and the concentration of metabolic ions as the Y-axis; mapping the relative concentrations of metabolic ions in the experimental samples to the rectangular coordinate system, fitting the relative concentrations using the least squares method to obtain a fitting curve, and obtaining the fitting concentration of the current experimental sample based on the fitting curve.

[0023] Preferably, the method further comprises calculating the residual amount of the metabolite ions: taking the ratio of the sum of the concentrations of the metabolite ions to the sum of the ions in the veterinary drug sample as the residual amount of the metabolite ions.

[0024] Preferably, the method for obtaining the relative concentration of metabolic ions in the experimental samples is: using gas chromatography-mass spectrometry to obtain a mass spectrum of each experimental sample, and taking the peak value of each metabolic ion in the mass spectrum as the relative concentration of the corresponding ion.

[0025] In a second aspect, the present invention provides a veterinary drug residue detection system based on spectroscopy technology, which adopts the following technical solution: The veterinary drug residue detection system based on spectral technology includes: a processor and a memory, wherein the memory stores computer program instructions, and when the computer program instructions are executed by the processor, the veterinary drug residue detection method based on spectral technology is implemented.

[0026] The above-mentioned veterinary drug residue detection method based on spectral technology is generated into a computer program and stored in a memory so as to be loaded and executed by a processor. Thus, a system is made based on the memory and the processor for easy use.

[0027] The present invention has the following technical effects: 1. The ion coding list can effectively distinguish the metabolic ions of veterinary drugs in each experimental sample. When calculating the veterinary drug residues in animals, the influence of metabolic ions is fully considered, which improves the accuracy of the calculation results of veterinary drug residues.

[0028] 2. The contamination degree of the current experimental sample is evaluated by the change in the content of veterinary drug metabolic ions that deviate from the expected relative concentration, so as to adaptively obtain smoothing parameters to obtain a more realistic metabolic ion content, thus avoiding misjudgment of the metabolic ion concentration in the current experimental sample due to contamination of the current experimental sample. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1The present invention is a flow chart of the veterinary drug residue detection method based on spectroscopy technology. DETAILED DESCRIPTION

[0030] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

[0031] In gas chromatography-mass spectrometry (GC-MS) analysis, the test sample is injected into the gas chromatograph and separated on the chromatographic column. Due to its different physical and chemical properties, each compound in the test sample has a different retention time on the chromatographic column. The compounds eluted from the chromatographic column are sent to the mass spectrometer for ionization. The ionized compounds will produce a series of ions with different mass-to-charge ratios. These ions are detected in the mass spectrometer to form a mass spectrum, in which each peak represents a specific ion and the peak height represents the ion intensity. If the concentration of a certain compound in the sample is higher, the corresponding ion peak intensity in the mass spectrum will be greater.

[0032] The present invention discloses a method for detecting veterinary drug residues based on spectroscopy technology. Figure 1 , including the following steps: S1: Acquire experimental samples at different times to obtain multiple experimental samples, and obtain veterinary drug samples and control samples.

[0033] Blood from animals before ingestion of veterinary drugs is collected as a control sample, and blood from animals at different times after ingestion of veterinary drugs is collected as experimental samples. Different times refer to blood collection within a certain interval after ingestion of veterinary drugs. The preset collection interval is once every 2 hours, and the collection cycle is one day.

[0034] S2: Construct a coding list of corresponding ions for veterinary drug samples, control samples and experimental samples. The coding list consists of ion codes, obtain the coding list of metabolic ions, and obtain the corresponding metabolic ions according to the coding list.

[0035] A unique ion code is assigned to each ion in the sample, that is, each ion corresponds to an ion code, for example: the ion codes are a, b, c, ..., and all ion codes in a sample form a code list. It can be seen that veterinary drug samples, control samples and experimental samples each correspond to a code list, and then the code list of metabolic ions is obtained. The expression of the code list of metabolic ions is:

[0036] In the formula, Represents the coding list of veterinary drug metabolic ions for the i-th experimental sample; represents the coding list of all ions in the i-th experimental sample; D represents the coding list of all ions in the control group sample; S represents the coding list of all ions in the veterinary drug sample.

[0037] Among them, veterinary drugs produce biological reactions and metabolites after being ingested into animals. Under the same animal feed conditions, it means that the ion types remain unchanged without being affected by veterinary drugs. Therefore, the parts of the experimental samples that have different ion codes from the control group samples and veterinary drug samples are the metabolites related to veterinary drugs in the experimental samples. Represents the list of ions in the ith experimental sample that ingests veterinary drugs that are common to the control sample and the veterinary drug samples that ingest veterinary drugs. The ions common to the control sample and the veterinary drug sample ingesting the veterinary drug are removed from all ion codes in the i-th experimental sample ingesting the veterinary drug, and the remaining ion list is the ion list of the metabolites of the veterinary drug.

[0038] S3: Obtain the relative concentration of metabolic ions in the experimental sample, and fit the relative concentration of metabolic ions in multiple experimental samples to obtain the fitting concentration of the current experimental sample.

[0039] The coding of metabolic ions can be obtained according to the ion list of metabolites. The mass spectrum of each experimental sample is obtained by gas chromatography-mass spectrometry. The peak value of each metabolic ion in the mass spectrum is used as the relative concentration of the corresponding ion. The relative concentration of the same metabolic ion in multiple experimental samples is fitted. The method is as follows: a rectangular coordinate system is constructed with time as the X-axis and the concentration of the metabolic ion as the Y-axis; the relative concentration of the metabolic ion in the experimental sample is mapped to the rectangular coordinate system, and the relative concentration is fitted by the least squares method to obtain a fitting curve, and the fitting concentration of the current experimental sample is obtained according to the fitting curve.

[0040] Exemplarily, for metabolic ions with ion code b, the metabolic ions b in experimental samples at different times (experimental samples at historical times) are mapped to a rectangular coordinate system, and then the relative concentration is fitted using the least squares method to obtain a fitting curve, and the fitting concentration of the current experimental sample is obtained based on the fitting curve.

[0041] S4: Calculate the abnormal index of metabolic ions in the current experimental sample. The abnormal index is positively correlated with the absolute value of the difference between the relative concentration and the fitted concentration.

[0042] In one embodiment, the abnormal index expression of the metabolic ion is:

[0043] In the formula, represents the abnormal index of the metabolic ions related to the hth veterinary drug in the i-th experimental sample; represents the relative concentration of the metabolite ion related to the hth veterinary drug in the i-th experimental sample; Represents the fitted concentration of the hth veterinary drug-related metabolite ion in the ith experimental sample.

[0044] The abnormality index represents the h-th metabolic ion related to veterinary drugs in the ith experimental sample of veterinary drug ingestion. The larger the value, the more significant the difference between the relative concentration of the corresponding metabolic ion and the ideal fitting curve, indicating that the corresponding metabolic ion in the experimental sample may be affected by external factors and has abnormalities. Therefore, the abnormality index reflects the degree of deviation of the relative concentration of the corresponding metabolic ion obtained by gas chromatography-mass spectrometry. The larger the value, the more the metabolic ion deviates from the fitting curve, indicating that the possibility of abnormality of the corresponding metabolic ion is greater.

[0045] In one embodiment, the abnormal index expression of the metabolic ion is:

[0046] In the formula, represents the abnormal index of the metabolic ions related to the hth veterinary drug in the i-th experimental sample; represents the relative concentration of the metabolite ion related to the hth veterinary drug in the i-th experimental sample; Represents the fitted concentration of the hth veterinary drug-related metabolite ion in the ith experimental sample.

[0047] S5: Calculate the contamination degree of the current experimental sample, where the contamination degree represents the degree of difference between the corresponding experimental sample and the historical experimental sample.

[0048] The expression of pollution degree is:

[0049] In the formula, represents the contamination degree of the i-th experimental sample, represents the abnormal index of the hth veterinary drug-related metabolic ion in the ith experimental sample, n represents the total number of categories of veterinary drug-related metabolic ions in the ith experimental sample, represents the average value of the abnormal index of the metabolic ions related to the hth veterinary drug in other experimental samples except the i-th experimental sample, represents the standard deviation of the abnormal index of the h-th veterinary drug-related metabolic ions of other experimental samples except the i-th experimental sample, and norm represents the normalization function.

[0050] in, Indicates the degree of deviation of the abnormal index of the metabolic ion related to the hth veterinary drug corresponding to the i-th experimental sample of veterinary drug intake from the average level of the abnormal index of the metabolic ion related to the hth veterinary drug corresponding to other experimental samples. The greater the degree of contamination of the experimental sample, the more likely it is that the experimental sample is affected by the pollutants, resulting in the abnormal index of the metabolic ion related to the hth veterinary drug significantly deviating from the expected range.

[0051] S6: Calculate and obtain the predicted concentration of the current experimental sample.

[0052] The ratio of the contamination degree of the current experimental sample to the sum of the contamination degrees of all experimental samples is used as the weight coefficient of the current experimental sample, and the inverse of the weight coefficient is used as the smoothing coefficient in the exponential smoothing algorithm. The predicted concentration of the current experimental sample is calculated using the exponential smoothing algorithm.

[0053] Among them, the expression coefficient of the weight coefficient of the current experimental sample is:

[0054] In the formula, The weight coefficient representing the contamination level of the current experimental sample of the ingested veterinary drug; Indicates the degree of contamination of the current experimental sample of the ingested veterinary drug; Indicates the number of days before the current test sample of the veterinary drug was ingested. where m is the total number of experimental samples before the current experimental sample of the veterinary drug.

[0055] It represents the ratio of the pollution degree of the current experimental sample to the sum of the pollution degrees of all samples. The weight coefficient reflects the influence of the pollution degree of the current sample on the pollution degree of the historical local samples. The larger the value, the greater the pollution degree of the current sample and the greater its weight in the local pollution degree.

[0056] If the contamination level of the current experimental sample is higher than that of all experimental samples, it means that the relative concentration of veterinary drug-related metabolic ions obtained for the current experimental sample is less reliable. Using a smaller smoothing parameter makes the smoothing process more dependent on the relative concentration of metabolic ions in historical experimental samples, thereby obtaining a predicted concentration of veterinary drug-related metabolic ions that is more in line with the current experimental sample.

[0057] S7: Obtain the optimal concentration of metabolic ions of the current experimental sample according to the concentration function of the metabolic ions. The expression of the concentration function is:

[0058] In the formula, represents the optimal concentration of the hth related metabolic ion in the current experimental sample, represents the predicted concentration of the hth related metabolic ion in the current experimental sample, represents the relative concentration of the hth related metabolic ion in the current experimental sample, W represents the contamination degree of the current experimental sample, Indicates The contamination degree of historical experimental samples is m, and m represents the total number of historical experimental samples.

[0059] if , indicating that the contamination level of the current experimental sample is higher than that of all experimental samples, indicating that the relative concentration of veterinary drug-related metabolic ions obtained by the current sample is less reliable. At this time, the relative concentration smoothing result of the relevant metabolic ions of the historical experimental samples is used as the final relative concentration of the corresponding metabolic ions in the current experimental sample; if This indicates that the analysis results of the current experimental samples are relatively reliable, and the original relative concentration can be directly used.

[0060] The residual amount of metabolic ions is calculated based on the optimal concentration of metabolic ions. The ratio of the sum of the concentrations of each metabolic ion to the sum of each ion in the veterinary drug sample is the residual amount of metabolic ions. The residual amount of veterinary drugs is further obtained based on the residual amount of metabolic ions. The specific method is to obtain a common coding list of the current experimental sample and the veterinary drug sample, obtain the residual veterinary drug ions in the experimental sample, and the ratio of the sum of the relative concentrations of each veterinary drug ions remaining in the experimental sample to the sum of each ion in the veterinary drug sample is the residual amount of veterinary drug ions; finally, the sum of the residual amount of metabolic ions and the residual amount of veterinary drug ions is the final veterinary drug residue.

[0061] An embodiment of the present invention also discloses a veterinary drug residue detection system based on spectral technology, including a processor and a memory, wherein the memory stores computer program instructions, and when the computer program instructions are executed by the processor, a veterinary drug residue detection method based on spectral technology according to the present invention is implemented.

[0062] The above system also includes other components well known to those skilled in the art, such as a communication bus and a communication interface, and their configuration and functions are known in the art, so they will not be described in detail here.

[0063] The above are all preferred embodiments of the present invention, and are not intended to limit the protection scope of the present invention. Therefore, any equivalent changes made based on the structure, shape, and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A veterinary drug residue detection method based on spectroscopy technology, characterized in that: Includes steps: Acquire experimental samples at different times to obtain multiple experimental samples, obtain the relative concentration and predicted concentration of metabolic ions in the experimental samples; fit the relative concentration of metabolic ions in multiple experimental samples to obtain the fitted concentration of the current experimental sample; calculate the abnormal index of metabolic ions in the current experimental sample, and the abnormal index is positively correlated with the absolute value of the difference between the relative concentration and the fitted concentration; calculate the contamination degree of the current experimental sample, and the contamination degree represents the degree of difference between the corresponding experimental sample and the historical experimental sample; obtain the optimal concentration of metabolic ions of the current experimental sample according to the concentration function of metabolic ions, and the expression of the concentration function is: In the formula, represents the optimal concentration of the hth related metabolic ion in the current experimental sample, represents the predicted concentration of the hth related metabolic ion in the current experimental sample, represents the relative concentration of the hth related metabolic ion in the current experimental sample, W represents the contamination degree of the current experimental sample, Indicates The contamination degree of historical experimental samples is m, and m represents the total number of historical experimental samples.

2. The veterinary drug residue detection method based on spectroscopy technology according to claim 1 is characterized in that: The method for obtaining metabolic ions is as follows: obtaining veterinary drug samples and control samples, constructing a coding list of corresponding ions for the veterinary drug samples, the control samples and the experimental samples, wherein the coding list is composed of ion codes; obtaining the coding list of metabolic ions, and obtaining corresponding metabolic ions according to the coding list; The expression of the metabolic ion code list is: In the formula, Represents the coding list of veterinary drug metabolic ions for the i-th experimental sample; represents the coding list of all ions in the i-th experimental sample; D represents the coding list of all ions in the control group sample; S represents the coding list of all ions in the veterinary drug sample.

3. The veterinary drug residue detection method based on spectroscopy technology according to claim 1 is characterized in that: The abnormal index expression of metabolic ions is: In the formula, represents the abnormal index of the metabolic ions related to the hth veterinary drug in the i-th experimental sample; represents the relative concentration of the metabolite ion related to the hth veterinary drug in the i-th experimental sample; Represents the fitted concentration of the hth veterinary drug-related metabolite ion in the ith experimental sample.

4. The veterinary drug residue detection method based on spectroscopy technology according to claim 1 is characterized in that: The abnormal index expression of metabolic ions is: In the formula, represents the abnormal index of the metabolic ions related to the hth veterinary drug in the i-th experimental sample; represents the relative concentration of the metabolite ion related to the hth veterinary drug in the i-th experimental sample; Represents the fitted concentration of the hth veterinary drug-related metabolite ion in the ith experimental sample.

5. The veterinary drug residue detection method based on spectroscopy technology according to claim 3 is characterized in that: The expression of pollution degree is: In the formula, represents the contamination degree of the i-th experimental sample, represents the abnormal index of the hth veterinary drug-related metabolic ion in the ith experimental sample, n represents the total number of categories of veterinary drug-related metabolic ions in the ith experimental sample, represents the average value of the abnormal index of the metabolic ions related to the hth veterinary drug in other experimental samples except the i-th experimental sample, represents the standard deviation of the abnormal index of the h-th veterinary drug-related metabolic ions of other experimental samples except the i-th experimental sample, and norm represents the normalization function.

6. The veterinary drug residue detection method based on spectroscopy technology according to claim 1 is characterized in that: The method for obtaining the predicted concentration is as follows: the ratio of the contamination degree of the current experimental sample to the sum of the contamination degrees of all experimental samples is used as the weight coefficient of the current experimental sample, the inverse of the weight coefficient is used as the smoothing coefficient in the exponential smoothing algorithm, and the predicted concentration of the current experimental sample is calculated using the exponential smoothing algorithm.

7. The veterinary drug residue detection method based on spectroscopy technology according to claim 1 is characterized in that: The method for fitting the relative concentrations of metabolic ions in multiple experimental samples to obtain the fitted concentration of the current experimental sample is as follows: constructing a rectangular coordinate system with time as the X-axis and the concentration of metabolic ions as the Y-axis; mapping the relative concentrations of metabolic ions in the experimental samples to the rectangular coordinate system, fitting the relative concentrations using the least squares method to obtain a fitting curve, and obtaining the fitting concentration of the current experimental sample based on the fitting curve.

8. The veterinary drug residue detection method based on spectroscopy technology according to claim 1 is characterized in that: The method also includes calculating the residual amount of the metabolite ions: the ratio of the sum of the concentrations of the metabolite ions to the sum of the ions in the veterinary drug sample is taken as the residual amount of the metabolite ions.

9. The veterinary drug residue detection method based on spectroscopy technology according to claim 1 is characterized in that: The method for obtaining the relative concentration of metabolic ions in the experimental samples is: using gas chromatography-mass spectrometry to obtain a mass spectrum of each experimental sample, and taking the peak value of each metabolic ion in the mass spectrum as the relative concentration of the corresponding ion.

10. The veterinary drug residue detection system based on spectroscopy technology is characterized by: include: A processor and a memory, wherein the memory stores computer program instructions, and when the computer program instructions are executed by the processor, the veterinary drug residue detection method based on spectroscopy technology according to any one of claims 1-9 is implemented.

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