A specimen collection device for PCR detection

Abstract

The present invention relates to the technical field of medical devices, and in particular to a sample collection device for PCR detection, comprising a sampling tube, a sampling mechanism and a protective cover, wherein the sampling tube comprises a tube body, and an opening is arranged at the bottom of the tube body; the sampling mechanism comprises a sampling rod, the sampling rod is located inside the tube body, a sampling cotton is arranged at the end of the sampling rod, a driving handle is fixedly connected to the upper end of the sampling rod, the driving handle is sleeved on the outside of the tube body and is threadedly matched with the tube body, the protective cover comprises an outer shell, the outer shell is sleeved on the bottom of the tube body, a protective opening is arranged at the bottom of the outer shell, the protective cover also comprises a sliding plate, the sliding plate can slide horizontally in the outer shell, and a connecting piece is arranged between the sliding plate and the tube body; a driving plate is rotatably arranged on the driving handle, the driving plate can be inserted into the outer shell and drive the sliding plate to move in a horizontal direction, so as to open the human oral cavity and the protective opening at the same time, and the connecting piece can be cut off at the same time, so as to realize the separation of the protective cover and the sampling tube.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a sample collection device for PCR detection. Background Art

[0002] PCR testing is a medical testing method. A small amount of secretions is taken from the human throat with a medical cotton swab, inoculated into a special culture dish, and then placed in a temperature-controlled device for culture. This can be used to understand the patient's condition, oral mucosa and pharyngeal infection.

[0003] Existing conventional PCR sampling usually requires medical staff to use cotton swabs to obtain the sample to be tested, then open the test tube, and finally seal the sample to be tested in the test tube. During the entire sampling process, medical staff can easily come into contact with the inside of the patient's mouth, which can easily cause cross-infection. The entire sampling process is cumbersome, and the sample obtained from the cotton swab may come into contact with pollutants exposed in the air, which is not conducive to ensuring the accuracy of the test results. Summary of the invention

[0004] Based on this, it is necessary to provide a sample collection device for PCR detection to address the technical problem that current PCR sampling is prone to cross-infection, thereby affecting detection accuracy.

[0005] The above purpose is achieved through the following technical solutions:

[0006] A sample collection device for PCR detection comprises a sampling tube, a sampling mechanism and a protective cover, wherein the sampling tube comprises a tube body, and an opening is provided at the bottom of the tube body;

[0007] The sampling mechanism comprises a sampling rod, the sampling rod is located inside the tube body, a sampling cotton is arranged at the end of the sampling rod, the upper end of the sampling rod is fixedly connected with a driving handle, the driving handle is sleeved outside the tube body and matched with the tube body thread, and the driving handle can be moved downward along the tube body by rotating the driving handle, thereby driving the sampling rod to extend from the opening;

[0008] The protective cover comprises a shell, the shell is sleeved on the bottom of the tube body, the bottom of the shell is provided with a protective opening, the protective opening corresponds to the opening, the protective cover also comprises a sliding plate, the sliding plate can slide horizontally in the shell, and a connecting piece is provided between the sliding plate and the tube body;

[0009] In the initial state, the sliding plate blocks the protective opening; a driving plate is rotatably provided on the driving handle, and the driving plate can be inserted into the outer shell and drive the sliding plate to move in the horizontal direction, thereby opening the human oral cavity and the protective opening at the same time. At this time, the driving plate can also cut off the connecting piece to separate the protective cover from the sampling tube.

[0010] Further, the bottom of the driving plate is a driving inclined surface, and the driving inclined surface inclines from the outside of the pipe body to the inside of the pipe body from top to bottom.

[0011] Further, a cutting edge is provided on the outer side surface of the driving plate. In the vertical direction, the lowermost end of the cutting edge is higher than the lowermost end of the driving inclined surface and lower than the uppermost end of the driving inclined surface.

[0012] Further, a plurality of driving plates are provided. Vertical insertion grooves are provided on the outer shell, and the vertical insertion grooves correspond to the driving plates one by one. A horizontal groove is also provided on the outer shell, and the horizontal groove communicates with the vertical insertion grooves.

[0013] Further, the sliding plate includes a vertical section and a horizontal section. The vertical section is located in the horizontal groove, and the horizontal section is used to block the protection opening. When the driving plate is inserted into the vertical insertion groove from top to bottom, the driving inclined surface will push the sliding plate to slide outwards along the horizontal groove.

[0014] Further, the connecting member is an elastic rope. One end of the elastic rope extends into the horizontal groove and is connected to the vertical section, and the other end of the elastic rope is connected to the outer side surface of the pipe body.

[0015] Further, a storage cavity is provided in the vertical section. The elastic rope is of a hollow structure, and the inside of the elastic rope communicates with the storage cavity. A virus preservation solution is placed in the storage cavity.

[0016] Further, a transfer cavity is provided on the driving plate, a communication port is provided on the pipe body, the left side of the transfer cavity can communicate with the storage cavity, and the right side of the transfer cavity can communicate with the communication port.

[0017] Further, a water-proof ring is provided on the periphery of the opening.

[0018] Further, an external thread is provided at the upper end of the pipe body, an internal thread is provided on the driving handle, and a plurality of through holes are provided on the pipe body. The through holes are used to guide the up and down movement of the driving plate, and the through holes correspond to the vertical insertion grooves.

[0019] The beneficial effects of the present invention are:

[0020] The sample collection device for PCR detection provided by the present invention, when in use, rotates the driving handle forward to move the driving plate downward along the tube body. The driving handle can drive the sampling rod to extend from the opening of the tube body. At the same time, the driving plate on the driving handle can be inserted into the outer shell of the protective cover, driving the sliding plate to slide outward horizontally, so as to open the protective opening of the protective cover. At the same time, the outward sliding of the sliding plate can expand the human oral cavity to facilitate the sampling rod to take samples. In addition, since the downward movement of the driving plate can cut off the connecting piece, separating the protective cover from the sampling tube. In this way, after sampling, the protective cover remains in the human oral cavity. By rotating the driving handle in the reverse direction, the sampling rod can be retracted into the tube body, so that the sampling rod will not be polluted by the external air, and medical staff do not need to touch the human oral cavity, improving the accuracy of subsequent detection results.

[0021] Secondly, after the driving plate of the present application cuts off the elastic rope, the virus preservation liquid in the sliding plate storage cavity will flow into the transfer cavity on the driving plate. After the driving plate moves up and resets, the transfer cavity can communicate with the communication port on the tube body, so that the virus preservation liquid will flow into the tube body to process the sample in the tube body. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 is a schematic three-dimensional structure diagram of a sample collection device for PCR detection provided by an embodiment of the present invention;

[0023] Figure 2 is Figure 1 the bottom view of

[0024] Figure 3 is Figure 2 the A-A cross-sectional view in

[0025] Figure 4 is a working state diagram of a sample collection device for PCR detection provided by an embodiment of the present invention;

[0026] Figure 5 is Figure 4 the bottom view of

[0027] Figure 6 is Figure 5 the B-B cross-sectional view in

[0028] Figure 7 is a schematic structure diagram of a sample collection device for PCR detection provided by an embodiment of the present invention;

[0029] Figure 8 is a schematic structure diagram of a sample collection device for PCR detection provided by an embodiment of the present invention;

[0030] Figure 9 is a schematic structure diagram of a sample collection device for PCR detection provided by an embodiment of the present invention.

[0031] Wherein:

[0032] 100, sampling mechanism; 101, driving handle; 102, driving plate; 103, driving inclined surface; 104, cutting edge; 105, transfer cavity; 106, sampling rod; 200, sampling tube; 201, tube body; 202, communication port; 203, water isolation ring; 204, through hole; 300, protective cover; 301, outer shell; 302, sliding plate; 303, storage cavity; 304, elastic rope; 305, protective port; 306, vertical insertion groove. Specific embodiments

[0033] In order to make the objectives, technical solutions and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below through embodiments and in conjunction with the accompanying drawings. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0034] The serial numbers assigned to the components herein, such as "first", "second", etc., are only used to distinguish the described objects and do not have any sequential or technical meaning. The "connection" and "coupling" mentioned in this application, unless otherwise specified, both include direct and indirect connections (couplings). In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention.

[0035] In the present invention, unless otherwise clearly specified and limited, the first feature being "above" or "below" the second feature may be that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "over" and "on" the second feature may be that the first feature is directly above or obliquely above the second feature, or merely indicates that the first feature has a higher horizontal height than the second feature. The first feature being "below", "beneath" and "under" the second feature may be that the first feature is directly below or obliquely below the second feature, or merely indicates that the first feature has a lower horizontal height than the second feature.

[0036] As Figures 1 to 9 shown, a specimen collection device for PCR detection provided by an embodiment of the present invention includes a sampling tube 200, a sampling mechanism 100 and a protective cover 300. The sampling tube 200 includes a tube body 201, and an opening is provided at the bottom of the tube body 201.

[0037] The sampling mechanism 100 includes a sampling rod 106 which is located inside the tube body 201. A sampling cotton is provided at the end of the sampling rod 106. The upper end of the sampling rod 106 is fixedly connected to a driving handle 101. The driving handle 101 is sleeved outside the tube body 201 and is in threaded cooperation with the tube body 201. By rotating the driving handle 101, the driving handle 101 can move downward along the tube body 201, thereby driving the sampling rod 106 to extend out from the opening.

[0038] The protective cover 300 includes a housing 301 which is sleeved at the bottom of the tube body 201. A protective opening 305 is provided at the bottom of the housing 301. The protective opening 305 corresponds to the opening. The protective cover 300 further includes a sliding plate 302 which can slide horizontally inside the housing 301. A connecting member is provided between the sliding plate 302 and the tube body 201.

[0039] In the initial state, the sliding plate 302 blocks the protective opening 305. A driving plate 102 is rotatably provided on the driving handle 101. The driving plate 102 can be inserted into the housing 301 and drive the sliding plate 302 to move horizontally, so as to open the human oral cavity and open the protective opening 305 at the same time. At this time, the driving plate 102 can also cut off the connecting member to realize the separation of the protective cover 300 from the sampling tube 200.

[0040] In one embodiment, the bottom of the driving plate 102 is a driving inclined surface 103 which inclines from the outside of the tube body 201 to the inside of the tube body 201 from top to bottom. In other embodiments, a wedge-shaped block is fixedly installed at the bottom of the driving plate 102.

[0041] In one embodiment, a cutting edge 104 is provided on the outer side surface of the driving plate 102. In the vertical direction, the lowermost end of the cutting edge 104 is higher than the lowermost end of the driving inclined surface 103 and lower than the uppermost end of the driving inclined surface 103. When the driving plate 102 moves downward, the horizontal sliding of the sliding plate 302 is realized first, and then the cutting of the connecting member is realized. In this embodiment, the cutting edge 104 and the driving plate 102 are integrally formed, which is convenient for processing. In other embodiments, the cutting edge 104 can be set as a metal blade and fixedly arranged on the driving plate 102.

[0042] In one embodiment, a plurality of driving plates 102 are provided. The housing 301 is provided with vertical insertion slots 306, which correspond to the driving plates 102 one by one. The housing 301 is further provided with horizontal slots, which communicate with the vertical insertion slots 306. In this embodiment, four driving plates 102 are provided and are evenly distributed along the circumference of the driving handle 101. The housing 301 is provided with four vertical insertion slots 306. The horizontal cross-sections of the driving plates 102 and the vertical insertion slots 306 are both arc-shaped. In other embodiments, the number of driving plates 102 and vertical insertion slots 306 can be set to two, six, or eight, as long as they are provided in pairs.

[0043] In one embodiment, the sliding plate 302 includes a vertical section and a horizontal section. The vertical section is located in the horizontal slot, and the horizontal section is used to block the protection opening 305. When the driving plate 102 is inserted into the vertical insertion slot 306 from top to bottom, the driving inclined surface 103 will push the vertical section of the sliding plate 302 to slide outward along the horizontal slot, driving the whole sliding plate 302 to slide outward. The number of the sliding plates 302 corresponds to the number of the driving plates 102. In this embodiment, four sliding plates 302 are provided, and each horizontal section of the sliding plates 302 is provided with a fan-shaped part, and the radian of the fan-shaped part is 90 degrees. In other embodiments, the number of sliding plates 302 can be set to two, six, or eight, and the radian of the fan-shaped part is adjusted accordingly.

[0044] In one embodiment, the connecting member is an elastic cord 304. One end of the elastic cord 304 extends into the horizontal slot and is connected to the vertical section, and the other end of the elastic cord 304 is connected to the outer side surface of the tube body 201.

[0045] In one embodiment, a storage cavity 303 is provided in the vertical section. The elastic cord 304 is of a hollow structure, and the inside of the elastic cord 304 communicates with the storage cavity 303. A virus preservation solution is placed in the storage cavity 303. In other embodiments, the connecting member is a telescopic tube, such as a corrugated tube.

[0046] In one embodiment, a transfer cavity 105 is provided on the driving plate 102. The tube body 201 is provided with a communication port 202. The left side of the transfer cavity 105 can communicate with the storage cavity, and the right side of the transfer cavity 105 can communicate with the communication port 202. The communication port 202 is inclined from outside to inside, so as to facilitate the flow of the virus preservation solution into the tube body 201.

[0047] In one embodiment, a water-proof ring 203 is provided on the periphery of the opening. The water-proof ring 203 has a certain height, so as to prevent the virus preservation solution from flowing out of the opening. In this embodiment, a sealing plug is further provided on the opening, and finally the opening is sealed to facilitate the transfer of the sampling tube 200.

[0048] In one embodiment, an external thread is provided at the upper end of the tube body 201, and an internal thread is provided on the driving handle 101. A plurality of through holes 204 are provided on the tube body 201. The through holes 204 are used to guide the driving plate 102 to move up and down, and the through holes 204 correspond to the vertical insertion slots 306. The through holes 204 are arc-shaped holes, which enable the driving plate 102 to be smoothly inserted into the vertical insertion slots 306 of the protective cover 300.

[0049] Combined with the above embodiments, the working principle and process of the PCR detection sample collection device according to the embodiments of the present invention are as follows:

[0050] During use, first rotate the driving handle 101 forward to make the driving plate 102 move downward along the through hole 204 of the tube body 201. While the driving handle 101 drives the sampling rod 106 to extend from the opening of the tube body 201, it can also make the driving plate 102 inserted into the vertical insertion slot 306 of the protective cover 300. Then, the driving inclined surface 103 at the bottom of the driving plate 102 will drive the sliding plate 302 to slide outward along the horizontal groove, so that the protective opening 305 of the protective cover 300 is opened. Multiple sliding plates 302 sliding outward simultaneously can open the human oral cavity, facilitating the sampling rod 106 to take samples. At this time, the outward movement of the sliding plate 302 will pull the elastic rope 304, making the elastic rope 304 taut. As the driving plate 102 continues to move downward, the cutting edge 104 on the outer side of the driving plate 102 will contact the elastic rope 304 and cut off the elastic rope 304, separating the sliding plate 302 from the tube body 201, that is, separating the protective cover 300 from the sampling tube 200. In this way, after sampling, the protective cover 300 will remain in the human oral cavity. Finally, rotate the driving handle 101 in the reverse direction to make the driving plate 102 move upward, and at the same time, the sampling rod 106 moves upward and retracts into the tube body 201, so that the sampling rod 106 will not be contaminated by the outside air, and medical staff do not need to touch the human oral cavity, improving the accuracy of subsequent detection results.

[0051] When the cutting edge 104 on the driving plate 102 cuts off the elastic rope 304, the virus preservation liquid in the storage cavity of the sliding plate 302 will flow into the transfer cavity 105 of the driving plate 102. After the driving plate 102 moves upward, the transfer cavity 105 can communicate with the communication port 202 on the tube body 201, so that the virus preservation liquid will flow into the tube body 201. Due to the presence of the water isolation ring 203, the virus preservation liquid will not flow out of the opening, realizing the preservation of the sample in the tube body 201. Finally, the opening can be sealed with a sealing plug to transfer the sampling tube 200.

[0052] The technical features of the above embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope recorded in this specification.

[0053] The above-described embodiments merely represent several implementation manners of the present invention. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all fall within the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the appended claims.

Claims

1. A sample collection device for PCR detection, characterized in that: It includes a sampling tube, a sampling mechanism and a protective cover, wherein the sampling tube includes a tube body, and an opening is provided at the bottom of the tube body; The sampling mechanism comprises a sampling rod, the sampling rod is located inside the tube body, a sampling cotton is arranged at the end of the sampling rod, the upper end of the sampling rod is fixedly connected with a driving handle, the driving handle is sleeved outside the tube body and matched with the tube body thread, and the driving handle can be moved downward along the tube body by rotating the driving handle, thereby driving the sampling rod to extend from the opening; The protective cover comprises a shell, the shell is sleeved on the bottom of the tube body, the bottom of the shell is provided with a protective opening, the protective opening corresponds to the opening, the protective cover also comprises a sliding plate, the sliding plate can slide horizontally in the shell, and a connecting piece is provided between the sliding plate and the tube body; In the initial state, the sliding plate blocks the protective opening; a driving plate is rotatably provided on the driving handle, and the driving plate can be inserted into the outer shell and drive the sliding plate to move in the horizontal direction, so as to open the human oral cavity and the protective opening at the same time. At this time, the driving plate can also cut off the connecting piece to realize the separation of the protective cover and the sampling tube. The bottom of the driving plate is a driving inclined plane, and the driving inclined plane is inclined from the outside of the tube body to the inside of the tube body from top to bottom. A cutting blade is provided on the outer side of the driving plate. In the up and down direction, the bottom end of the cutting blade is higher than the bottom end of the driving inclined plane and lower than the top end of the driving inclined plane. The connecting piece is an elastic rope.

2. The sample collection device for PCR detection according to claim 1, characterized in that: There are multiple drive plates, the shell is provided with vertical insertion slots, the vertical insertion slots correspond to the drive plates one by one, and the shell is also provided with horizontal slots, which are connected with the vertical insertion slots.

3. The sample collection device for PCR detection according to claim 2, characterized in that: The sliding plate includes a vertical section and a horizontal section, the vertical section is located in the horizontal groove, and the horizontal section is used to cover the protective opening. When the driving plate is inserted into the vertical insertion groove from top to bottom, the driving inclined surface will push the sliding plate to slide outward along the horizontal groove.

4. The sample collection device for PCR detection according to claim 3, characterized in that: One end of the elastic rope extends into the horizontal groove and is connected to the vertical section, and the other end of the elastic rope is connected to the outer side surface of the tube body.

5. The sample collection device for PCR detection according to claim 4, characterized in that: A storage cavity is arranged in the vertical section, the elastic rope is a hollow structure, the interior of the elastic rope is communicated with the storage cavity, and virus preservation liquid is placed in the storage cavity.

6. The sample collection device for PCR detection according to claim 5, characterized in that: The driving plate is provided with a transfer cavity, the tube body is provided with a communication port, the left side of the transfer cavity can be communicated with the storage cavity, and the right side of the transfer cavity can be communicated with the communication port.

7. The sample collection device for PCR detection according to claim 1, characterized in that: A water-isolating ring is arranged around the opening.

8. The sample collection device for PCR detection according to claim 2, characterized in that: The upper end of the tube body is provided with an external thread, the driving handle is provided with an internal thread, and the tube body is provided with a plurality of through holes, which are used to guide the driving plate to move up and down, and the through holes correspond to the vertical insertion slots.

Images