Cardiovascular drug sustained release microsphere implantation device

Abstract

The invention relates to the technical field of medicine experiments, in particular to a cardiovascular medicine sustained release microsphere implanting device which comprises a platform, and a mouse fixing mechanism used for fixing a mouse is arranged on the table top of the platform; the tail clamping mechanism comprises a moving column, a hollow cylinder, a grooved wheel and a moving plate, a moving mechanism used for enabling the moving column to move is arranged at the bottom of the platform, a notch is formed in the top of the moving column, through holes are formed in the two ends of the notch, and the two ends of the hollow cylinder are fixed in the two through holes. The mouse tail clamping device is provided with the grooved wheel and the tail clamping mechanism, the tail of a mouse is placed in a groove of the grooved wheel, the tail clamping mechanism is used for clamping the tail end of the tail of the mouse, the tail clamping mechanism is then changed at the position of moving the grooved wheel, for example, the grooved wheel moves towards the mouse, and the tail clamping mechanism moves downwards, so that the tail of the mouse is kept tight; an experimenter observes the vein position and then carries out injection operation.

Description

Technical Field

[0001] The invention relates to the technical field of drug experiments, in particular to a cardiovascular drug sustained-release microsphere implantation device. Background Art

[0002] Microspheres generally refer to spherical particles with a particle size between 50nm and 2mm. Bioactive microspheres carry reactive groups such as -NH2, -COOH, -SH, etc. Microspheres have obvious surface effects due to their small size, such as good material affinity, good biocompatibility, and easy absorption and migration in the body. In recent years, with the continuous increase in the types of microsphere carrier materials, the application scope of microspheres has also been continuously expanded. They have been widely used in many fields such as cytology, immunology, microbiology, molecular biology, clinical diagnosis and treatment. This article intends to briefly review the research progress of the application of microspheres in the biomedical field in recent years from the two aspects of microspheres of different materials in drug carriers and tissue engineering.

[0003] Drug development requires experiments, which are generally conducted on mice. Microsphere needles are needed to inject cardiovascular drug sustained-release microspheres into mice. However, microsphere needles are long and not easy to manipulate. This is mainly because the injection method for mice is generally through the tail vein. The longer the needle, the more difficult it is for the operator to hold it. At the same time, the experimenter needs to hold the mouse's tail with one hand and complete the injection with the other hand, which increases the difficulty of the operation. Summary of the invention

[0004] Based on the deficiencies in the prior art mentioned in the above background technology, the present invention provides a cardiovascular drug sustained-release microsphere implant device.

[0005] The present invention overcomes the above technical problems by adopting the following technical solutions, specifically:

[0006] A cardiovascular drug sustained-release microsphere implant device, comprising:

[0007] A platform, wherein the table top of the platform is provided with a mouse fixing mechanism for fixing mice;

[0008] The tail clamping mechanism comprises a moving column, a hollow cylinder, a groove wheel and a moving plate, wherein a moving mechanism for moving the moving column is arranged at the bottom of the platform, a notch is arranged at the top of the moving column, through holes are arranged at both ends of the notch, both ends of the hollow cylinder are fixed in the two through holes, the wheel hole of the groove wheel is rotatably mounted on the hollow cylinder, a moving structure for moving the moving plate up and down is arranged inside the notch, and a tail fixing mechanism for fixing the tail end of the mouse is arranged on one side of the moving plate.

[0009] As a further solution of the present invention: the mouse fixing mechanism comprises:

[0010] A fixed cylinder, which is horizontally arranged and fixed to the platform, and one end of the fixed cylinder is provided with a tail hole;

[0011] A baffle, wherein the baffle is integrally slidably inserted into the fixed tube, the top of the baffle protrudes upward to form a convex block, a sliding groove opening is provided on the outer top of the fixed tube, and the convex block is slidably arranged in the sliding groove hole;

[0012] The fixing structure is arranged on the baffle and can fix the baffle in the fixing cylinder.

[0013] As a further solution of the present invention: the fixing structure comprises:

[0014] A first threaded column, a first threaded hole is formed on the top of the protrusion and passes through the baffle, and an outer side of the first threaded column is installed in the first threaded hole through threads;

[0015] A rubber block, wherein the bottom end of the first threaded column is fixed with a rubber block;

[0016] The first knob, the top of the first threaded column is fixed to the first knob.

[0017] As a further solution of the present invention: the moving mechanism comprises:

[0018] A transverse plate, wherein a groove is formed on the outer side of the transverse plate, and a connecting plate is fixed between one end of the transverse plate and the bottom of the platform;

[0019] A plurality of guide rods, both ends of which are respectively fixed on the two ends of the groove, and the bottom end of the movable column is slidably sleeved on each guide rod;

[0020] A second threaded column, both ends of the groove are provided with first rotation holes, the two ends of the second threaded column rotate the two first rotation holes respectively, the outer side of the movable column is provided with a second threaded hole, and the outer side of the second threaded column is installed in the second threaded hole through a thread;

[0021] A second knob, one end of the second threaded column is fixed to the second knob.

[0022] As a further solution of the present invention: the mobile structure includes:

[0023] Two fixed plates, the two fixed plates are entirely fixed in the notches of the moving column and are distributed up and down;

[0024] A third threaded column, a second rotating hole is opened on the opposite side of the two fixed plates, and both ends of the third threaded column are rotatably installed in the two second rotating holes respectively. A third threaded hole is opened on the outer side of the movable plate, and the outer side of the third threaded column is installed in the third threaded hole through threads.

[0025] As a further solution of the present invention: a third rotating hole is opened on both sides of the recess of the movable plate, and a synchronization rod is installed inside the two third rotating holes for common rotation, and transmission gears coaxially arranged therewith are fixed at both ends of the synchronization rod, and racks are fixed on both sides of the groove of the cross plate, and the two racks are respectively meshed with two transmission gears, and a first bevel gear coaxially arranged therewith is fixed on the outer side of the synchronization rod, and a second bevel gear coaxially arranged therewith and meshed with the first bevel gear is fixed at one end of the third threaded column.

[0026] As a further solution of the present invention: the tail fixing mechanism comprises:

[0027] A recessed frame, both ends of which are fixed to the movable plate;

[0028] A fourth threaded column, wherein a fourth threaded hole is formed on the outer side of the recessed frame, and the outer side of the fourth threaded column is installed in the fourth threaded hole through threads;

[0029] A first concave block, one end of the fourth threaded column being rotatably mounted on the first concave block;

[0030] The second concave block is fixed to the movable plate, and the first concave block and the second concave block are arranged alternately.

[0031] As a further solution of the present invention: a controller is fixed on one side of the movable column, a positioning plate is fixed on the outside of the controller, the positioning plate is located in a hollow cylinder, a through opening is opened on the top of the hollow cylinder, and an irradiation lamp electrically connected to the controller is fixed on one end of the positioning plate.

[0032] After adopting the above structure, the present invention has the following advantages compared with the prior art:

[0033] First, the present invention is provided with a groove wheel and a tail clamping mechanism, the tail of the mouse is prevented from being in the groove of the groove wheel, and the tail clamping mechanism is used to clamp the tail end of the mouse's tail. When the position of the groove wheel is moved, the tail clamping mechanism is subsequently changed. For example, when the groove wheel moves toward the mouse, the tail clamping mechanism is subsequently moved down, so that the mouse's tail is kept tight, and the experimenter observes the vein position and then performs the injection operation;

[0034] Secondly, the groove wheel of the present invention is made of transparent material, and an irradiation light is arranged inside the groove wheel, which can illuminate the tail vein of the mouse (the tail of the mouse has good light transmittance), making it convenient for the operator to observe and quickly find the vein of the tail of the mouse, thereby improving the injection efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0036] Figure 2 It is a schematic structural diagram of the mouse fixing mechanism of the present invention from the first perspective.

[0037] Figure 3 It is a schematic structural diagram of the mouse fixing mechanism of the present invention from a second viewing angle.

[0038] Figure 4 It is a schematic diagram of the internal structure of the baffle of the present invention.

[0039] Figure 5 It is a schematic diagram of the three-dimensional structure of the tail clamping mechanism of the present invention.

[0040] Figure 6 It is a schematic diagram of the three-dimensional structure of the moving column of the present invention from the first perspective.

[0041] Figure 7 It is a schematic diagram of the three-dimensional structure of the moving column of the present invention from a second viewing angle.

[0042] Figure 8 It is a schematic diagram of the internal structure of the sheave of the present invention.

[0043] Fig. 9 It is a schematic diagram of the three-dimensional structure of the tail fixing mechanism of the present invention.

[0044] In the figure: 1, platform; 2, mouse fixing mechanism; 3, tail clamping mechanism; 4, tail hole; 5, fixed cylinder; 6, baffle; 7, first threaded column; 8, rubber block; 9, cross plate; 10, second threaded column; 11, guide rod; 12, rack; 13, moving column; 14, transmission gear; 15, synchronization rod; 16, first bevel gear; 17, second bevel gear; 18, tail fixing mechanism; 19, moving plate; 20, third threaded column; 21, fixed plate; 22, groove wheel; 23, hollow cylinder; 24, controller; 25, irradiation lamp; 26, positioning plate; 27, through port; 28, recessed frame; 29, fourth threaded column; 30, first recessed block; 31, second recessed block; 32, connecting plate. DETAILED DESCRIPTION

[0045] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0046] See also Figures 1 to 9 In an embodiment of the present invention, a cardiovascular drug sustained-release microsphere implant device comprises:

[0047] Platform 1, the table top of platform 1 is provided with a mouse fixing mechanism 2 for fixing mice;

[0048] The tail clamping mechanism 3 includes a moving column 13, a hollow cylinder 23, a groove wheel 22 and a moving plate 19, wherein a moving mechanism for moving the moving column 13 is arranged at the bottom of the platform 1, a notch is provided at the top of the moving column 13, through holes are provided at both ends of the notch, both ends of the hollow cylinder 23 are fixed in the two through holes, the wheel hole of the groove wheel 22 is rotatably mounted on the hollow cylinder 23, a moving structure for moving the moving plate 19 up and down is arranged inside the notch, and a tail fixing mechanism 18 for fixing the tail end of the mouse is arranged on one side of the moving plate 19.

[0049] Specifically, the mouse fixing mechanism 2 includes:

[0050] A fixed tube 5, which is horizontally arranged and fixed to the platform 1, and a through hole 4 is formed at one end of the fixed tube 5;

[0051] The baffle 6 is integrally slidably inserted into the fixed tube 5, the top of the baffle 6 protrudes upward to form a convex block, and a slide groove is provided on the top of the outer side of the fixed tube 5, and the convex block is slidably arranged in the slide groove hole;

[0052] From the above connection relationship, it can be known that: the baffle 6 is pulled out from the fixed tube 5, and then the mouse's buttocks are pushed toward the through-tail hole 4, and the mouse's tail passes through the through-tail hole 4, and the baffle 6 is inserted, so that the baffle 6 pushes the mouse, and the range of movement of the mouse in the fixed tube 5 is reduced until the mouse cannot move.

[0053] The fixing structure is arranged on the baffle plate 6 and can fix the baffle plate 6 in the fixing tube 5 .

[0054] Specifically, the fixed structure includes:

[0055] A first threaded column 7, a first threaded hole is formed on the top of the protrusion, and the threaded hole passes through the baffle 6, and the outer side of the first threaded column 7 is installed in the first threaded hole through threads;

[0056] A rubber block 8 is fixed to the bottom end of the first threaded column 7;

[0057] A first knob, a top of the first threaded column 7 is fixed to the first knob;

[0058] It can be known from the above connection relationship that: by rotating the first threaded column 7 through the first knob, the rubber block 8 on the first threaded column 7 contacts the fixing tube 5, so that the baffle 6 is fixed.

[0059] Specifically, the mobile mechanism includes:

[0060] A transverse plate 9, the outer side of which is provided with a groove, and a connecting plate 32 is fixed between one end of the transverse plate 9 and the bottom of the platform 1;

[0061] A plurality of guide rods 11, both ends of which are fixed to both ends of the grooves, and the bottom end of the movable column 13 is slidably sleeved on each guide rod 11;

[0062] The second threaded column 10 has first rotation holes at both ends of the groove, and the two ends of the second threaded column 10 rotate the two first rotation holes respectively, and the outer side of the movable column 13 has a second threaded hole, and the outer side of the second threaded column 10 is installed in the second threaded hole through a thread;

[0063] A second knob, one end of the second threaded column 10 is fixed to the second knob;

[0064] It can be known from the above connection relationship that due to the arrangement of each guide rod 11, the movable column 13 can only slide linearly relative to the cross plate 9, and the second thread is rotated by the second knob, and the second thread drives the movable column 13 through thread transmission.

[0065] Specifically, the mobile structure includes:

[0066] Two fixed plates 21, the two fixed plates 21 are fixed in the notch of the moving column 13 and are distributed up and down;

[0067] The third threaded column 20, a second rotating hole is opened on the opposite side of the two fixed plates 21, and the two ends of the third threaded column 20 are respectively rotatably installed in the two second rotating holes. A third threaded hole is opened on the outer side of the movable plate 19, and the outer side of the third threaded column 20 is installed in the third threaded hole through threads.

[0068] Specifically, third rotating holes are provided on both sides of the notch of the moving plate 19, and a synchronization rod 15 is installed inside the two third rotating holes for common rotation, and transmission gears 14 coaxially arranged therewith are fixed at both ends of the synchronization rod 15, racks 12 are fixed on both sides of the groove of the cross plate 9, and the two racks 12 are respectively meshed with the two transmission gears 14, and a first bevel gear 16 coaxially arranged therewith is fixed on the outer side of the synchronization rod 15, and a second bevel gear 17 coaxially arranged therewith and meshed with the first bevel gear 16 is fixed at one end of the third threaded column 20;

[0069] It can be known from the above connection relationship that when the moving column 13 moves, the transmission gear 14 rolls on the gear, and the transmission gear 14 drives the synchronization rod 15 to rotate, and the first bevel gear 16 on the synchronization rod 15 drives the second bevel gear 17 to drive the third threaded column 20, and the third threaded column 20 drives the moving plate 19 to move through the threaded transmission form, that is, when the moving column 13 moves away from the platform 1, the moving plate 19 moves upward, thereby straightening the mouse's tail and lengthening it, which is convenient for the insertion of the microsphere needle.

[0070] Specifically, the tail fixing mechanism 18 includes:

[0071] A recessed frame 28, both ends of which are fixed to the movable plate 19;

[0072] A fourth threaded column 29, a fourth threaded hole is formed on the outer side of the recessed frame 28, and the outer side of the fourth threaded column 29 is installed in the fourth threaded hole by threads;

[0073] A first concave block 30, one end of the fourth threaded column 29 is rotatably mounted on the first concave block 30;

[0074] The second concave block 31 is fixed to the movable plate 19, and the first concave block 30 and the second concave block 31 are staggered;

[0075] From the above connection relationship, it can be known that: the tail end of the mouse is inserted between the first recessed block 30 and the second recessed block 31, and the fourth threaded column 29 is rotated, the fourth threaded column 29 pushes the first recessed block 30, and the notch of the first recessed block 30 presses the tail end of the mouse onto the second recessed block 31.

[0076] Specifically, a controller 24 is fixed to one side of the moving column 13, a positioning plate 26 is fixed to the outside of the controller 24, the positioning plate 26 is located in the hollow cylinder 23, a through opening 27 is opened at the top of the hollow cylinder 23, and an irradiation lamp 25 electrically connected to the controller 24 is fixed to one end of the positioning plate 26. Here, the groove wheel 22 is supplemented. The groove wheel 22 is made of a transparent material;

[0077] It can be known from the above connection relationship that when the irradiation lamp 25 is turned on, the irradiation light can illuminate the tail vein of the mouse (the tail of the mouse has good light transmittance), which is convenient for the operator to observe.

[0078] Working principle:

[0079] In the first step, the baffle 6 is pulled out from the fixed tube 5, and then the mouse's butt is pushed toward the through-tail hole 4, and the mouse's tail is passed through the through-tail hole 4, and the baffle 6 is inserted, so that the baffle 6 pushes the mouse to reduce the range of movement of the mouse in the fixed tube 5 until the mouse cannot move, and the first threaded column 7 is turned by the first knob, and the rubber block 8 on the first threaded column 7 contacts the fixed tube 5, so that the baffle 6 is fixed;

[0080] The second step is to place the mouse's tail in the groove of the groove wheel 22, and then insert the tail end of the mouse's tail between the first concave block 30 and the second concave block 31, and rotate the fourth threaded column 29, so that the fourth threaded column 29 pushes the first concave block 30, and the notch of the first concave block 30 presses the tail end of the mouse onto the second concave block 31;

[0081] The third step is to turn on the irradiation lamp 25, so that the irradiation light can illuminate the tail vein of the mouse (the tail of the mouse has good light transmittance), which is convenient for the operator to observe;

[0082] In the fourth step, due to the setting of each guide rod 11, the moving column 13 can only slide linearly relative to the horizontal plate 9. The second thread is rotated by the second knob, and the second thread drives the moving column 13 through thread transmission. The transmission gear 14 rolls on the gear, and the transmission gear 14 drives the synchronization rod 15 to rotate. The first bevel gear 16 on the synchronization rod 15 drives the second bevel gear 17 to drive the third threaded column 20. The third threaded column 20 drives the moving plate 19 to move through thread transmission, that is, when the moving column 13 moves away from the platform 1, the moving plate 19 moves upward, thereby straightening the mouse's tail and lengthening it, which is convenient for the insertion of the microsphere needle.

[0083] It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention.

Claims

1. A cardiovascular drug sustained-release microsphere implant device, characterized in that: include: A platform (1), wherein the surface of the platform (1) is provided with a mouse fixing mechanism (2) for fixing a mouse; A tail clamping mechanism (3), the tail clamping mechanism (3) comprising a moving column (13), a hollow cylinder (23), a groove wheel (22) and a moving plate (19), wherein a moving mechanism for moving the moving column (13) is arranged at the bottom of the platform (1), a notch is arranged at the top of the moving column (13), through holes are arranged at both ends of the notch, both ends of the hollow cylinder (23) are fixed in the two through holes, the wheel hole of the groove wheel (22) is rotatably mounted on the hollow cylinder (23), a moving structure for moving the moving plate (19) up and down is arranged inside the notch, and a tail fixing mechanism (18) for fixing the tail end of a mouse is arranged on one side of the moving plate (19).

2. A cardiovascular drug sustained-release microsphere implant device according to claim 1, characterized in that: The mouse fixing mechanism (2) comprises: A fixed cylinder (5), the fixed cylinder (5) is arranged horizontally and fixed to the platform (1), and a through hole (4) is formed at one end of the fixed cylinder (5); A baffle (6), wherein the baffle (6) is integrally slidably inserted into the fixed tube (5), the top of the baffle (6) protrudes upward to form a convex block, a sliding groove opening is provided on the outer top of the fixed tube (5), and the convex block is slidably arranged in the sliding groove hole; A fixing structure is arranged on the baffle (6) and is capable of fixing the baffle (6) in the fixing cylinder (5).

3. A cardiovascular drug sustained-release microsphere implant device according to claim 2, characterized in that: The fixed structure comprises: A first threaded column (7), a first threaded hole is formed on the top of the protrusion, and the threaded hole passes through the baffle (6), and the outer side of the first threaded column (7) is installed in the first threaded hole through threads; A rubber block (8), the bottom end of the first threaded column (7) is fixed with a rubber block (8); A first knob, wherein the top of the first threaded column (7) is fixed to the first knob.

4. A cardiovascular drug sustained-release microsphere implant device according to claim 1, characterized in that: The moving mechanism comprises: A transverse plate (9), wherein a groove is formed on the outer side of the transverse plate (9), and a connecting plate (32) is fixed between one end of the transverse plate (9) and the bottom of the platform (1); A plurality of guide rods (11), both ends of the plurality of guide rods (11) are respectively fixed on both ends of the groove, and the bottom end of the movable column (13) is slidably sleeved on each guide rod (11); A second threaded column (10), both ends of the groove are provided with first rotation holes, the two ends of the second threaded column (10) respectively rotate the two first rotation holes, the outer side of the movable column (13) is provided with a second threaded hole, and the outer side of the second threaded column (10) is installed in the second threaded hole through a thread; A second knob, one end of the second threaded column (10) is fixed to the second knob.

5. A cardiovascular drug sustained-release microsphere implant device according to claim 4, characterized in that: The mobile structure comprises: Two fixed plates (21), the two fixed plates (21) are entirely fixed in the recess of the movable column (13) and are distributed up and down; A third threaded column (20), a second rotation hole is opened on the opposite side of the two fixed plates (21), and the two ends of the third threaded column (20) are respectively rotatably installed in the two second rotation holes, and a third threaded hole is opened on the outer side of the movable plate (19), and the outer side of the third threaded column (20) is installed in the third threaded hole through threads.

6. A cardiovascular drug sustained-release microsphere implant device according to claim 5, characterized in that: A third rotating hole is provided on both sides of the notch of the movable plate (19), a synchronous rod (15) is installed in the two third rotating holes for common rotation, a transmission gear (14) coaxially arranged therewith is fixed at both ends of the synchronous rod (15), a rack (12) is fixed on both sides of the groove of the transverse plate (9), the two racks (12) are respectively meshed with the two transmission gears (14), a first bevel gear (16) coaxially arranged therewith is fixed on the outer side of the synchronous rod (15), and a second bevel gear (17) coaxially arranged therewith and meshed with the first bevel gear (16) is fixed at one end of the third threaded column (20).

7. The cardiovascular drug sustained-release microsphere implant device according to claim 1, characterized in that: The tail fixing mechanism (18) comprises: A recessed frame (28), both ends of which are fixed to the movable plate (19); A fourth threaded column (29), a fourth threaded hole is formed on the outer side of the recessed frame (28), and the outer side of the fourth threaded column (29) is installed in the fourth threaded hole by means of threads; A first concave block (30), one end of the fourth threaded column (29) being rotatably mounted on the first concave block (30); The second concave block (31) is fixed to the movable plate (19), and the first concave block (30) and the second concave block (31) are arranged in an alternating manner.

8. The cardiovascular drug sustained-release microsphere implant device according to claim 1, characterized in that: A controller (24) is fixed on one side of the movable column (13), a positioning plate (26) is fixed on the outside of the controller (24), the positioning plate (26) is located in the hollow cylinder (23), a through opening (27) is opened on the top of the hollow cylinder (23), and an irradiation lamp (25) electrically connected to the controller (24) is fixed on one end of the positioning plate (26).

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