Solution preparation device and method

Abstract

The invention relates to a solution preparation device and method, belongs to the technical field of experimental reagent preparation, and aims to solve the technical problems of large-volume solution preparation and pH adjustment. The method comprises the steps of cleaning the inner wall of the pipeline, cleaning the outer wall of the liquid inlet pipe orifice, pre-filling the pipeline with water, injecting water into the target solution container, pre-filling the pipeline with a to-be-diluted solution, injecting the to-be-diluted solution and stirring. The device comprises a liquid conveying mechanism, a positioning mechanism, a control mechanism, a cleaning mechanism and an auxiliary mechanism. The device is used for preparing a diluted solution.

Description

Technical Field

[0001] The invention belongs to the technical field of experimental reagent preparation, and particularly relates to a solution preparation device and method. Background Art

[0002] In the fields of environmental monitoring, waste liquid treatment, biochemical analysis and testing, analytical methods have been greatly developed, and analytical instruments have become more and more sophisticated. However, the preparation of reagents closely related to sample separation, purification and analysis is still in the manual stage, and reagent preparation is achieved through steps such as adding liquid with a pipette, setting the volume with a volumetric flask, and mixing. The concentration of manually prepared reagents is greatly affected by human factors, prone to errors, and parallelism cannot be guaranteed. In addition, for solutions that require precise pH control, manual preparation is inefficient.

[0003] At present, the solution dilution devices sold on the market are mainly suitable for the preparation of small-volume standard solutions. For example, the maximum volume prepared by the dilution and standardization instrument is 100mL, which cannot meet the reagent requirements of chemical experiments. The solution dilution devices reported in the patents are mostly used for the dilution of water samples, standard solutions, biological samples, etc. There are no reports of devices or methods for reagent preparation or pH adjustment functions. In addition, these reported devices cannot all be batch-produced and fully automatic. Summary of the invention

[0004] Aiming at the problem that existing dilution devices cannot realize large volume solution preparation and pH adjustment, the present invention proposes a solution preparation device and method.

[0005] The technical solution adopted by the present invention to solve the technical problem is:

[0006] A solution preparation device comprises a liquid conveying mechanism, a positioning mechanism, a control mechanism, a cleaning mechanism and an auxiliary mechanism.

[0007] The liquid conveying mechanism includes a plurality of channels for solution to be diluted, a water inlet channel, an air channel, an acid channel, an alkali channel, a first cleaning channel, a second cleaning channel, a first injection channel, a second injection channel, a first peristaltic pump, a second peristaltic pump, a first multi-channel valve, a second multi-channel valve, and a dual-channel valve;

[0008] The medium of each diluted solution channel, water inlet channel, air channel, acid channel, and alkali solution channel can pass through the first multi-channel valve, the dual-channel valve, the first peristaltic pump or the second peristaltic pump, the second multi-channel valve, the first injection channel or the second injection channel in sequence to the target solution holding container or the waste liquid tank.

[0009] The medium transported by the first cleaning channel and the second cleaning channel cleans the first injection channel, the second injection channel and the outside of the pH meter respectively, and the waste liquid generated by the cleaning enters the waste liquid tank and then flows into the waste liquid barrel.

[0010] The positioning mechanism comprises a target solution containing container, a mechanical arm, a lifting frame and a bracket.

[0011] The mechanical arm is installed on the housing of the auxiliary mechanism, the output end of the first injection channel, the output end of the second injection channel, and the pH meter are fixed on the mechanical arm, and the mechanical arm is controlled by the control mechanism and can move in a horizontal plane at a certain height. The pH meter is used to measure the pH value of the liquid in the container containing the target solution.

[0012] The bracket is fixed on the housing, the bracket is provided with a positioning hole, the lifting frame is located in the positioning hole, and the target solution container is located on the lifting frame. The lifting frame and the target solution container are placed on the upper side of the stirring component, and the stirring component is located above the weighing component.

[0013] The cleaning mechanism comprises a waste liquid tank and a waste liquid barrel. The waste liquid tank is located inside the housing, and the waste liquid barrel is located outside the housing. The liquid in the waste liquid tank flows into the waste liquid barrel.

[0014] The auxiliary mechanism comprises a pH meter, a weighing component, a stirring component and a shell.

[0015] The stirring component and the weighing component are integrated under the bracket, and the stirring component is located above the weighing component.

[0016] The control mechanism controls the rotation speed and time of the stirring component, and the weighing component and the pH meter are connected to the control mechanism to transmit control signals.

[0017] The weighing component is used for weighing the stirring component, the lifting frame, and the target solution holding container.

[0018] The auxiliary mechanism of the above solution preparation device also includes a ventilation component and a lighting component.

[0019] The ventilation component is located at the rear of the housing and is used to discharge the corrosive gas generated during the solution preparation process.

[0020] The lighting component is located at the upper part of the housing and is used for lighting the solution preparation process.

[0021] The above solution preparation device has 8 channels for solution to be diluted, namely, a first channel for solution to be diluted, a second channel for solution to be diluted, a third channel for solution to be diluted, a fourth channel for solution to be diluted, a fifth channel for solution to be diluted, a sixth channel for solution to be diluted, a seventh channel for solution to be diluted, and an eighth channel for solution to be diluted.

[0022] The first peristaltic pump is used for liquid delivery at a flow rate of 10mL / min to 200mL / min, and the second peristaltic pump is used for liquid delivery at a flow rate of 0.1mL / min to 10mL / min. The control mechanism controls the on and off of the first peristaltic pump and the second peristaltic pump as well as the volume and flow rate of the delivered liquid.

[0023] The material of the to-be-diluted solution channel, the water inlet channel, the air channel, the acid solution channel, the alkali solution channel, the first injection channel or the second injection channel is PFA or PTFE.

[0024] The control mechanism is a controller.

[0025] The weighing component is a balance with a measuring range of not less than 30 kg. The stirring component is a magnetic stirring device.

[0026] A solution preparation method comprises the following steps:

[0027] Step 1: Clean the pipeline

[0028] Cleaning the pipeline includes cleaning the inner wall of the pipeline and cleaning the outer wall of the liquid inlet pipe.

[0029] Step 2: Pre-fill the pipeline with water

[0030] The pipeline before the first multi-channel valve is pre-filled with water.

[0031] Step 3: Add water

[0032] Add a certain volume of water to the target solution container.

[0033] Step 4: Prefill the pipeline with the solution to be diluted

[0034] The i-th solution to be diluted is filled before the first multi-channel valve.

[0035] Step 5: Inject the solution to be diluted

[0036] Based on the solution information library, inject the solution to be diluted in volume dilution mode or mass dilution mode;

[0037] A stirring component is used to stir the liquid in the target solution holding container until the liquid is uniform to obtain a diluted solution.

[0038] The solution preparation method further comprises step 6, pH adjustment.

[0039] Inject acid or alkali solution to adjust the pH of the existing solution, that is, pH adjustment mode. The specific process is as follows:

[0040] Use a pH meter to initially measure the pH of the existing solution.

[0041] When the pH value of the existing solution does not meet the requirements, determine whether the regulating liquid is acid or add alkali. Pre-fill the regulating liquid into the pipeline, inject the regulating liquid according to the minimum step amount, stir it with a stirring component until it is uniform, and measure the pH value of the solution again with a pH meter.

[0042] It is determined again whether the adjusted pH value of the existing solution meets the termination condition. If not, the above pH adjustment operation is repeated until the adjusted pH value of the existing solution meets the requirement, thereby obtaining a pH-adjusted diluted solution.

[0043] In the above solution preparation method, the existing solution may be a diluted solution obtained by adopting a volume dilution mode or a mass dilution mode.

[0044] The above solution preparation method, step 6, further comprises:

[0045] The termination condition for determining pH adjustment is: the deviation between the measured pH value and the target pH value is within 3%;

[0046] The selection basis for determining whether the regulating liquid is an acid solution or an alkaline solution is: if the measured pH value is less than the target pH value, the alkaline solution is injected through the alkaline solution channel; if the measured pH value is greater than the target pH value, the acid solution is injected through the acid solution channel;

[0047] Pre-fill the regulating liquid to fill the acid or alkali solution before the first multi-channel valve. The specific process is: Assume that the volume of the acid channel or alkali channel before the first multi-channel valve is V fp0 , use the second peristaltic pump to inject V into the acid channel or the alkali channel fp0 +2mL of acid or alkali solution, use the air inlet channel to discharge the acid or alkali solution after the first multi-channel valve into the waste liquid tank through the dual-channel valve, the second peristaltic pump, the first injection channel or the second injection channel, and further flow into the waste liquid barrel;

[0048] The step size of acid or alkali solution injection is 1.5mL;

[0049] The inner wall of the pipeline is cleaned. The specific process is: 10 ml of water is injected into the first injection channel or the second injection channel from the acid channel or the alkali channel through the first multi-channel valve, the dual-channel valve and the second peristaltic pump, and air is used from the air inlet channel through the first multi-channel valve, the dual-channel valve and the second peristaltic pump to discharge the water in the channel from the first injection channel or the second injection channel into the waste liquid tank, and further flows into the waste liquid bucket;

[0050] The outer wall of the liquid inlet pipe is cleaned. The specific process is: water is injected into the first cleaning channel or the second cleaning channel from the water inlet channel through the first multi-channel valve, the dual-channel valve and the first peristaltic pump. The outflowing water flushes the first injection channel or the second injection channel, and the waste liquid is discharged into the waste liquid tank and further flows into the waste liquid barrel. The flushing continues for 5 minutes.

[0051] The solution preparation method further includes step 7, cleaning the pipeline again. The process of cleaning the pipeline again is the same as step 1.

[0052] In the above solution preparation method, in step 1, the process of cleaning the inner wall of the pipeline is:

[0053] Use a certain amount of water from the water inlet channel through the first multi-channel valve, the dual-channel valve and the first peristaltic pump, and inject it into the first liquid injection channel or the second liquid injection channel. Use air from the air inlet channel through the first multi-channel valve, the dual-channel valve, and the first peristaltic pump to discharge the water in the channel from the first liquid injection channel or the second liquid injection channel into the waste liquid tank, and further flow into the waste liquid barrel.

[0054] In step 1, the process of cleaning the outer wall of the liquid inlet pipe opening is:

[0055] Water is injected from the water inlet channel into the first cleaning channel or the second cleaning channel through the first multi-channel valve, the dual-channel valve and the first peristaltic pump. The outflowing water flushes the first injection channel or the second injection channel, and the waste liquid is discharged into the waste liquid tank and further flows into the waste liquid barrel.

[0056] In step 2, the process of pre-filling the pipeline with water is:

[0057] Fill the water before the first multi-channel valve. Assume that the volume of the water inlet channel before the first multi-channel valve is V f0 , use the first peristaltic pump to add V to the water inlet channel f0 +2mL of water, use the air inlet channel to discharge the water after the first multi-channel valve into the waste liquid tank through the dual-channel valve, the first peristaltic pump, the first injection channel or the second injection channel, and further flow into the waste liquid barrel.

[0058] In step 3, the process of injecting water is:

[0059] If the volume of water injected is V r >50mL, use the first peristaltic pump to add V to the water inlet channel r The water behind the first multi-channel valve is injected into the target solution holding container through the air inlet channel via the dual-channel valve, the first peristaltic pump, the first injection channel or the second injection channel;

[0060] If the volume of water injected is V r ≤50mL, use the second peristaltic pump to add V to the water inlet channel r The water behind the first multi-channel valve is injected into the target solution holding container through the air inlet channel via the dual-channel valve, the second peristaltic pump, the first injection channel or the second injection channel.

[0061] In step 4, the specific process of pre-filling the pipeline with the solution to be diluted is:

[0062] Assume that the volume of the pipeline of the i-th to-be-diluted solution channel before the first multi-channel valve is V fi0 , use the first peristaltic pump to add V to the water inlet channel fi0+2mL of the i-th solution to be diluted, use the air inlet channel to discharge the i-th solution to be diluted after the first multi-channel valve into the waste liquid tank through the dual-channel valve, the first peristaltic pump, the first injection channel or the second injection channel, and further flow into the waste liquid barrel.

[0063] In step 5, in the volume dilution mode, the injection amount is controlled according to the volume of the solution to be diluted, and the solution to be diluted is injected. The injection process is:

[0064] If the volume of the diluted solution V is injected i >50mL, use the first peristaltic pump to add V to the i-th channel of the solution to be diluted i The i-th solution to be diluted is injected into the target solution holding container through the air inlet channel via the dual-channel valve, the first peristaltic pump, the first injection channel or the second injection channel;

[0065] If the volume of the diluted solution V is injected i ≤50mL, use the second peristaltic pump 17 to add V to the i-th channel of the solution to be diluted i The i-th solution to be diluted is injected into the target solution holding container through the air inlet channel via the dual-channel valve, the second peristaltic pump, the first injection channel or the second injection channel;

[0066] In step 5, in the mass dilution mode, the injection amount is controlled according to the mass of the solution to be diluted, and the solution to be diluted is injected. The specific process is:

[0067] If the mass of the diluted solution injected is m i >50g, use the first peristaltic pump; if the mass of the diluted solution injected is m i When ≤50g, use the second peristaltic pump. Add m i / ρ i +5mL of the i-th solution to be diluted, use the air inlet channel to inject the i-th solution to be diluted after the first multi-channel valve into the target solution holding container through the dual-channel valve, the first peristaltic pump or the second peristaltic pump, the first injection channel or the second injection channel, and the control mechanism controls the injection speed and injection amount of the i-th solution to be diluted according to the data fed back by the weighing component. When the target mass differs by 50g, the first peristaltic pump is switched to the second peristaltic pump through the dual-channel valve. When approaching the target mass, the liquid injection speed is gradually reduced until the data fed back by the weighing component is consistent with m i When the deviation is within 0.3%, the control mechanism controls the second peristaltic pump to stop running.

[0068] In the above solution preparation method, in step 1, 10 ml of water is used to clean the inner wall of the pipeline and the outer wall of the liquid inlet nozzle, and the outer wall of the liquid inlet nozzle is cleaned for 5 minutes.

[0069] In step 3 and step 4, the first peristaltic pump or the second peristaltic pump is used to inject water or the added volume of the solution i to be diluted, and the control mechanism controls the number of steps of the first peristaltic pump or the second peristaltic pump to achieve this.

[0070] In step 5, the solution information library includes density ρ and molar concentration c information of the solution to be diluted, the solvent and the target solution.

[0071] The beneficial effects of the present invention are:

[0072] A solution preparation device integrates dilution and pH adjustment functions, and can achieve fully automatic and accurate preparation of multi-solute, 100ml-2000ml volume solutions, meeting the requirements of chemical experiments for batch production, parallelism and quality control, greatly improving the efficiency of reagent preparation, and at the same time avoiding the time for experimental operators to contact with highly corrosive solutions, effectively protecting the health of personnel.

[0073] A solution preparation method uses air purge when pre-filling the pipeline, which greatly saves preparation time and solute dosage. The method prepares the solution in both volume and mass modes, and calculates the solute and solvent dosage based on the density of the solution, ensuring high accuracy of the solution concentration. BRIEF DESCRIPTION OF THE DRAWINGS

[0074] Figure 1 is a schematic diagram of a liquid delivery mechanism according to an embodiment of the present invention;

[0075] Figure 2 Schematic diagram of a solution preparation device according to an embodiment of the present invention;

[0076] Figure 3 A flow chart of the preparation process of the volume dilution mode according to an embodiment of the present invention;

[0077] Figure 4 A flowchart of the preparation process of the mass dilution mode according to an embodiment of the present invention;

[0078] Figure 5 A flowchart of the preparation process of the dilution + pH adjustment mode according to an embodiment of the present invention.

[0079] The reference numerals are as follows:

[0080] 1. First solution channel to be diluted, 2. Second solution channel to be diluted, 3. Third solution channel to be diluted, 4. Fourth solution channel to be diluted, 5. Fifth solution channel to be diluted, 6. Sixth solution channel to be diluted, 7. Seventh solution channel to be diluted, 8. Eighth solution channel to be diluted, 9. Water inlet channel, 10. Air channel, 11. Acid channel, 12. Alkaline channel, 13. First cleaning channel, 14. Second cleaning channel, 15. First injection channel, 16. Second injection channel, 17 .First peristaltic pump, 18.Second peristaltic pump, 19.First multi-channel valve, 20.Second multi-channel valve, 21.Dual-channel valve, 22.Target solution holding container, 23.Controller, 24.Liquid transfer mechanism, 25.Casing, 26.Robot arm, 27.pH meter, 28.Illumination component, 29.Ventilation component, 30.Lifting frame, 31.Positioning hole, 32.Bracket, 33.Weighing component, 34.Stirring component, 35.pH meter protection liquid, 36.Waste liquid barrel, 37.Waste liquid tank. DETAILED DESCRIPTION

[0081] The present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0082] An automatic solution preparation device for dilution + pH adjustment includes five parts: a liquid conveying mechanism 24, a positioning mechanism, a control mechanism, a cleaning mechanism, and an auxiliary mechanism;

[0083] The liquid conveying mechanism 24 includes a first solution channel 1 to be diluted, a second solution channel 2 to be diluted, a third solution channel 3 to be diluted, a fourth solution channel 4 to be diluted, a fifth solution channel 5 to be diluted, a sixth solution channel 6 to be diluted, a seventh solution channel 7 to be diluted, an eighth solution channel 8 to be diluted, a water inlet channel 9, an air channel 10, an acid channel 11, an alkali channel 12, a first cleaning channel 13, a second cleaning channel 14, a first injection channel 15, a second injection channel 16, a first peristaltic pump 17, a second peristaltic pump 18, a first multi-channel valve 19, a second multi-channel valve 20, and a dual-channel valve 21; Figure 1 shown.

[0084] The first peristaltic pump 17 is used for conveying liquid with a large flow rate (10-200 mL / min) and for conveying liquid with a small flow rate (0.1-10 mL / min). The controller 23 controls the on / off of the first peristaltic pump 17 and the second peristaltic pump 18 as well as the volume and flow rate of the conveyed liquid.

[0085] Among them, the first multi-channel valve 19 is used to select the sample injection channel, which has four fixed channels and 8 channels for the solution to be diluted. The fixed channels are the water inlet channel 12, the air channel 11, the acid channel 10 and the alkali channel 9. The second multi-channel valve 20 is used to select the sample outlet channel, which has the first injection channel 15, the second injection channel 16, the first cleaning channel 13, and the second cleaning channel 14. The material of the channel is PFA or PTFE;

[0086] The positioning mechanism includes a target solution container 22, a mechanical arm 26, a lifting frame 30, a positioning hole 31, and a bracket 32; Figure 2 shown.

[0087] The target solution holding container 22 is a conventional reagent bottle, and the material includes glass, PFA, PP, PET, etc. The volume of the target solution holding container 22 includes 100mL, 250mL, 500mL, 1000mL and larger volumes;

[0088] The lifting frame 30 is used to lift the 100mL and 250mL target solution holding containers 22 so that the height of the bottle mouth is consistent with the height of the 1000mL bottle mouth;

[0089] The positioning hole 31 is a hole opened on the bracket 32, and the hole is located directly above the stirring component 34, and is used to define the position of the target solution holding container 22; Figure 2 shown.

[0090] The robot arm 26 can move in the X and Z directions. There are two limit holes in the Z direction for fixing the liquid inlet tube and the pH meter 27. Controlling the coordinates in the X and Z directions can realize the accurate insertion of the first injection channel 15, the second injection channel 16 and the pH meter 27 into the target solution container 22;

[0091] The control mechanism includes a controller 23;

[0092] The cleaning mechanism includes a waste liquid tank 37, a waste liquid barrel 36, etc.; the liquid transported by the first cleaning channel 13 and the second cleaning channel 14 cleans the first injection channel 15, the second injection channel 16 and the outside of the pH meter 27 respectively, and the waste liquid generated by cleaning enters the waste liquid tank 37 and then flows into the waste liquid barrel 36;

[0093] The auxiliary mechanism includes a pH meter 27, a weighing component 33, a stirring component 34, a ventilation component 29, a lighting component 28, and a device housing 25; Figure 2 shown.

[0094] The controller 23 controls the speed and time of the stirring component 34, and the weighing component 33 and the pH meter 27 are connected to the controller 23 to transmit control signals;

[0095] The stirring component 34 and the weighing component 33 are integrated under the bracket 32, and the stirring component 34 is located above the weighing component 33;

[0096] The stirring component 34 uses magnetic stirring to achieve uniform mixing of the solution, and the weighing component 33 uses a balance with a range of not less than 30 kg to achieve weighing of the stirring component 34, the lifting frame 30, and the target solution container 22;

[0097] Wherein, the ventilation component 29 is located at the rear of the device housing and is used to discharge the corrosive gas generated during the device preparation of the solution;

[0098] Among them, the lighting component 28 is located in the upper part of the device housing, which is convenient for observing the solution preparation process;

[0099] Based on a dilution + pH adjustment solution automatic preparation device, a solution preparation method is proposed. Based on a solution information library, four modes are included, namely, volume dilution mode, mass dilution mode, dilution + pH adjustment mode, and pH adjustment mode only. After the user independently selects the four modes of solution preparation according to the requirements for the concentration accuracy of the target solution, the controller 23 controls the operation of the liquid conveying mechanism 24, the positioning mechanism, the cleaning mechanism, the auxiliary mechanism and other components to realize the automatic preparation of the solution.

[0100] The solution information library includes the density ρ and molar concentration c information of the solution to be diluted, the solvent and the target solution, which are input into the controller 23 by the user;

[0101] Among them, the volume dilution mode, mass dilution mode, dilution + pH adjustment mode, and pH adjustment mode only are respectively applicable to four scenarios. The specific judgment method is: when only diluting the solution without adjusting the pH and the accuracy requirement of the solution concentration is not high, select the volume dilution mode; when only diluting the solution without adjusting the pH and the accuracy requirement of the solution concentration is high (within 5%), select the mass dilution mode; when diluting and preparing a solution with a specific pH, select the dilution + pH adjustment mode; when only adjusting the pH of an existing solution, select the pH adjustment mode;

[0102] The preparation process of volume dilution mode is: cleaning pipeline - water prefilling pipeline - injecting water, the volume is V r - Prefill the line with the solution to be diluted 1 - Inject the solution to be diluted 1, volume V1 - Inject water, volume V r - Prefill the pipeline with the solution to be diluted 2 - Inject the solution to be diluted 2, volume V2 - Inject water, volume V r - ...Prefill the pipeline with solution n to be diluted - Inject solution n to be diluted, volume V n -Inject water with volume V r -Stir the solution evenly -Clean the pipeline; Figure 3 shown.

[0103] Among them, the added volume V of water and solution i to be diluted r and V i The calculation idea is: given the target solution volume V, density ρ, and molar concentration c of component i in the target solution i In addition, the molar concentration of the solution i to be diluted is C i , density ρ i , the density of water is ρ r , then the volume of the diluted solution i that needs to be added is V i =V*c i / C i ; The volume of water is V0 = (V*ρ-ΣV i ρ i ) / ρ r ; In the preparation process V r =V0 / (n+1)

[0104] Wherein, cleaning the pipeline includes cleaning the inner wall of the pipeline and cleaning the outer wall of the liquid inlet pipe port;

[0105] The cleaning steps of the inner wall of the pipeline are: 10 ml of water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first injection channel 15 or the second injection channel 16, and air is passed from the air inlet channel 10 through the first multi-channel valve 19, the dual-channel valve 21, the first peristaltic pump 17 to discharge the water in the channel from the first injection channel 15 or the second injection channel 16 into the waste liquid tank 37, and further flows into the waste liquid barrel 36. 10 ml of water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the second peristaltic pump 18 into the first injection channel 15 or the second injection channel 16, and air is passed from the air inlet channel 10 through the first multi-channel valve 19, the dual-channel valve 21, the second peristaltic pump 18 to discharge the water in the channel from the first injection channel 15 or the second injection channel 16 into the waste liquid tank 37, and further flows into the waste liquid barrel 36;

[0106] The steps for cleaning the outer wall of the liquid inlet port are: water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first cleaning channel 13 or the second cleaning channel 14, the outflowing water flow flushes the first injection channel 15 or the second injection channel 16, and the waste liquid is discharged into the waste liquid tank 37 and further flows into the waste liquid barrel 36, and the flushing is continued for 5 minutes;

[0107] The step of pre-filling the pipeline with water is as follows: to fill the pipeline with water before the first multi-channel valve 19, assuming that the pipeline volume of the water inlet channel 9 before the first multi-channel valve 19 is V f0 , use the first peristaltic pump 17 to add (V f0+2) mL of water, the water after the first multi-channel valve 19 is discharged into the waste liquid tank 37 through the double-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by the air inlet channel 10, and further flows into the waste liquid barrel 36;

[0108] The steps of injecting water with a volume of are: if V r >50mL, add V to the water inlet channel 9 using the first peristaltic pump 17 r The water after the first multi-channel valve 19 is injected into the target solution holding container 22 through the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by the air inlet channel 10; if V r ≤50mL, add V to the water inlet channel 9 using the second peristaltic pump 18 r The water after the first multi-channel valve 19 is injected into the target solution holding container 22 through the double-channel valve 21, the second peristaltic pump 18, the first injection channel 15 or the second injection channel 16 by the air inlet channel 10;

[0109] The step of pre-filling the pipeline with the i-th solution to be diluted is as follows: to fill the i-th solution to be diluted before the first multi-channel valve 19, assuming that the pipeline volume of the i-th solution channel i before the first multi-channel valve 19 is V fi0 , use the first peristaltic pump 17 to add (V fi0 +2) mL of the i-th solution to be diluted, the i-th solution to be diluted after the first multi-channel valve 19 is discharged into the waste liquid tank 37 through the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by the air inlet channel 10, and further flows into the waste liquid barrel 36;

[0110] Among them, the solution to be diluted i is injected, and the volume is V i The steps are: If V i >50mL, use the first peristaltic pump 17 to add V to the i-th channel i of the solution to be diluted i The i-th solution to be diluted is injected into the target solution holding container 22 through the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by the air inlet channel 10; if V i ≤50mL, use the second peristaltic pump 17 to add V to the i-th channel of the solution to be diluted i The i-th solution to be diluted is injected into the target solution holding container 22 through the air inlet channel 10 via the dual-channel valve 21, the second peristaltic pump 18, the first injection channel 15 or the second injection channel 16 after the i-th solution to be diluted after the first multi-channel valve 19;

[0111] The step of stirring the solution uniformly is: using the controller 23 to control the stirring member 34 to stir the solution at a certain speed for a certain time;

[0112] The added volume of water and the solution i to be diluted is realized by controlling the number of steps of the peristaltic pump by software;

[0113] The preparation process of mass dilution mode is: cleaning pipeline - water prefilling pipeline - injection water, the mass is m r - Prefill the pipeline with the solution to be diluted 1 - Inject the solution to be diluted 1, with a mass of m1 - Inject water, with a mass of m r - Prefill the pipeline with the solution to be diluted 2 - Inject the solution to be diluted 2, with a mass of m2 - Inject water, with a mass of m r - ...Prefill the pipeline with solution n to be diluted - Inject solution n to be diluted, with a mass of m n -Inject water with a mass of m r -Stir the solution evenly -Clean the pipeline; Figure 4 shown.

[0114] The calculation idea of ​​the added mass of the solution to be diluted and water is as follows: given the target solution volume V, density ρ, and molar concentration c of component i in the target solution, i In addition, the molar concentration of the solution i to be diluted is C i , density ρ i , the density of water is ρ r , then the mass of the diluted solution i that needs to be added is m i =V*c i * i / C i ; Water mass is m0=V*ρ-ΣV i ρ i ρ r ; In the preparation process, m r =m0 / (n+1);

[0115] Wherein, cleaning the pipeline includes cleaning the inner wall of the pipeline and cleaning the outer wall of the liquid inlet pipe port;

[0116] The cleaning steps of the inner wall of the pipeline are: 10 ml of water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first injection channel 15 or the second injection channel 16, and air is passed from the air inlet channel 10 through the first multi-channel valve 19, the dual-channel valve 21, the first peristaltic pump 17 to discharge the water in the channel from the first injection channel 15 or the second injection channel 16 into the waste liquid tank 37, and further flows into the waste liquid barrel 36. 10 ml of water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the second peristaltic pump 18 into the first injection channel 15 or the second injection channel 16, and air is passed from the air inlet channel 10 through the first multi-channel valve 19, the dual-channel valve 21, the second peristaltic pump 18 to discharge the water in the channel from the first injection channel 15 or the second injection channel 16 into the waste liquid tank 37, and further flows into the waste liquid barrel 36;

[0117] The steps for cleaning the outer wall of the liquid inlet port are: water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first cleaning channel 13 or the second cleaning channel 14, the outflowing water flow flushes the first injection channel 15 or the second injection channel 16, and the waste liquid is discharged into the waste liquid tank 37 and further flows into the waste liquid barrel 36, and the flushing is continued for 5 minutes;

[0118] The step of pre-filling the pipeline with water is as follows: to fill the pipeline with water before the first multi-channel valve 19, assuming that the pipeline volume of the water inlet channel 9 before the first multi-channel valve 19 is V f0 , use the first peristaltic pump 17 to add (V f0 +2) mL of water, the water after the first multi-channel valve 19 is discharged into the waste liquid tank 37 through the double-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by the air inlet channel 10, and further flows into the waste liquid barrel 36;

[0119] Among them, the injected water has a mass of m r The steps are: using the first peristaltic pump 17 to add (V r +5) mL of water, use the air inlet channel 10 to inject the water after the first multi-channel valve 19 into the target solution holding container 22 through the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16, and use the weighing component 33 to feed back the weighing data to the controller 23, which determines and controls the switching of the dual-channel valve 21. When the mass of the injected solution is equal to the target mass m r The deviation is about 50g, the second peristaltic pump 18 is switched, and water is injected into the target solution holding container 22 by the second peristaltic pump 18 through the first injection channel 15 or the second injection channel 16. When the weighing data fed back by the weighing component 33 is consistent with the target mass m r When the deviation is within 0.3%, the controller 23 controls the second peristaltic pump 18 to stop running;

[0120] The step of pre-filling the pipeline with the i-th solution to be diluted is as follows: to fill the i-th solution to be diluted before the first multi-channel valve 19, assuming that the pipeline volume of the i-th solution channel i before the first multi-channel valve 19 is V fi0 , use the first peristaltic pump 17 to add (V fi0 +2) mL of the i-th solution to be diluted, the i-th solution to be diluted after the first multi-channel valve 19 is discharged into the waste liquid tank 37 through the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by the air inlet channel 10, and further flows into the waste liquid barrel 36;

[0121] Among them, the injected diluted solution i has a mass of m i The steps are: using the first peristaltic pump 17 (solution mass m i >50g) or the second peristaltic pump 18 (solution mass m i ≤50g) is added to the i-th solution channel i to be diluted (m i / ρ i +5) mL of the i-th solution to be diluted, the i-th solution to be diluted after the first multi-channel valve 19 is pumped through the air inlet channel 10 via the dual-channel valve 21 and the first peristaltic pump 17 (solution mass m i >50g) or the second peristaltic pump 18 (solution mass m i ≤50g), the first injection channel 15 or the second injection channel 16 injects the target solution into the container 22, and the controller 23 controls the injection speed and injection amount of the to-be-diluted solution i according to the data fed back by the weighing component 33. When the target mass differs by 50g, the first peristaltic pump 17 is switched to the second peristaltic pump 18 through the dual-channel valve 21. When approaching the target mass, the liquid injection speed is gradually reduced until the data fed back by the weighing component 33 is consistent with m. i When the deviation is within 0.3%, the controller 23 controls the second peristaltic pump 18 to stop running;

[0122] The step of stirring the solution uniformly is: using the controller 23 to control the stirring member 34 to stir the solution at a certain speed for a certain time;

[0123] The preparation process of the dilution + pH adjustment mode is as follows: after the solution is diluted by the volume mode or the mass mode, the pH of the diluted solution is initially measured by the pH meter 27 to determine whether the termination condition is met. If not, it is determined whether to add acid or alkali to adjust the pH of the solution, pre-fill the adjustment liquid into the pipeline, inject the minimum step amount of the adjustment liquid, stir the solution evenly with the stirring component 34, measure the pH of the solution with the pH meter 27, determine whether the termination condition is met, if not, repeat the above pH adjustment operation until the measured pH of the solution meets the termination condition, stir the solution evenly, and clean the pipeline; Figure 5shown.

[0124] The termination condition for determining pH adjustment is: the deviation between the measured pH value and the target pH value is within 3%;

[0125] The selection basis for distinguishing the acid solution and the alkali solution is as follows: after the solution is stirred evenly by the stirring component 34, the pH of the solution is tested by the pH meter 27. If the measured pH value is less than the target pH value, the alkali solution is injected through the alkali solution channel 12. If the measured pH value is greater than the target pH value, the acid solution is injected through the acid solution channel 11.

[0126] The pre-filling regulating liquid step is as follows: to fill the acid solution or alkali solution before the first multi-channel valve 19, assuming that the pipeline volume of the acid solution channel 11 or the alkali solution channel 12 before the first multi-channel valve 19 is V fp0 , use the second peristaltic pump 18 to inject (V fp0 +2) mL of acid or alkali solution, the acid or alkali solution after the first multi-channel valve 19 is discharged into the waste liquid tank 37 through the double-channel valve 21, the second peristaltic pump 18, the first injection channel 15 or the second injection channel 16 by the air inlet channel 10, and further flows into the waste liquid barrel 36;

[0127] Among them, the step volume of injecting acid or alkali solution is 1.5mL;

[0128] Wherein, cleaning the pipeline includes cleaning the inner wall of the pipeline and cleaning the outer wall of the liquid inlet pipe port;

[0129] The cleaning steps of the inner wall of the pipeline are as follows: 10 ml of water is injected into the first injection channel 15 or the second injection channel 16 from the acid channel 11 or the alkali channel 12 through the first multi-channel valve 19, the dual-channel valve 21 and the second peristaltic pump 18, and air is used from the air inlet channel 10 through the first multi-channel valve 19, the dual-channel valve 21 and the second peristaltic pump 18 to discharge the water in the channel from the first injection channel 15 or the second injection channel 16 into the waste liquid tank 37, and further flows into the waste liquid barrel 36;

[0130] The steps for cleaning the outer wall of the liquid inlet port are: water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first cleaning channel 13 or the second cleaning channel 14, the outflowing water flow flushes the first injection channel 15 or the second injection channel 16, and the waste liquid is discharged into the waste liquid tank 37 and further flows into the waste liquid barrel 36, and the flushing is continued for 5 minutes;

[0131] The preparation steps of the pH adjustment mode only are as follows: use the pH meter 27 to initially measure the pH of the solution, the controller 23 determines whether the termination condition is met, if not, pre-fill the adjustment liquid into the pipeline, inject the minimum step amount, stir the solution evenly with the stirring component 34, use the pH meter 27 to measure the pH of the solution, the controller 23 determines whether the termination condition is met, if not, repeat the above pH adjustment operation until the pH of the solution measured by the pH meter 27 meets the termination condition, stir the solution evenly with the stirring component 34, and clean the pipeline.

[0132] The termination condition for determining pH adjustment is: the deviation between the measured pH value and the target pH value is within 3%;

[0133] The selection basis for distinguishing the acid solution and the alkali solution is: if the measured pH value is less than the target pH value, the alkali solution is injected through the alkali solution channel 12; if the measured pH value is greater than the target pH value, the acid solution is injected through the acid solution channel 11;

[0134] The pre-filling regulating liquid step is as follows: to fill the acid solution or alkali solution before the first multi-channel valve 19, assuming that the pipeline volume of the acid solution channel 11 or the alkali solution channel 12 before the first multi-channel valve 19 is V fp0 , use the second peristaltic pump 18 to inject (V fp0 +2) mL of acid or alkali solution, the acid or alkali solution after the first multi-channel valve 19 is discharged into the waste liquid tank 37 through the double-channel valve 21, the second peristaltic pump 18, the first injection channel 15 or the second injection channel 16 by the air inlet channel 10, and further flows into the waste liquid barrel 36;

[0135] Among them, the step volume of injecting acid or alkali solution is 1.5mL;

[0136] Wherein, cleaning the pipeline includes cleaning the inner wall of the pipeline and cleaning the outer wall of the liquid inlet pipe port;

[0137] The cleaning steps of the inner wall of the pipeline are as follows: 10 ml of water is injected into the first injection channel 15 or the second injection channel 16 from the acid channel 11 or the alkali channel 12 through the first multi-channel valve 19, the dual-channel valve 21 and the second peristaltic pump 18, and air is used from the air inlet channel 10 through the first multi-channel valve 19, the dual-channel valve 21 and the second peristaltic pump 18 to discharge the water in the channel from the first injection channel 15 or the second injection channel 16 into the waste liquid tank 37, and further flows into the waste liquid barrel 36;

[0138] The cleaning steps for the outer wall of the liquid inlet pipe opening are: water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first cleaning channel 13 or the second cleaning channel 14, the outflowing water flow flushes the first injection channel 15 or the second injection channel 16, and the waste liquid is discharged into the waste liquid tank 37, and further flows into the waste liquid barrel 36, and the flushing is continued for 5 minutes.

[0139] Example 1

[0140] Based on an automatic solution preparation device and method of dilution + pH adjustment, two bottles of 1000mL 1mol / L nitric acid solution are prepared with concentrated nitric acid in a PP reagent bottle using a volume dilution mode.

[0141] Implementation process: Place two target solution holding containers 22 (PP reagent bottles) on the two positioning holes 31 of the bracket 32, input the volume 1000mL, concentration 1mol / L and density 1.035g / mL of the target solution in the controller 23, and the concentration 15mol / L and density 1.4g / mL of the concentrated nitric acid solution to be diluted, and then use the volume dilution mode to prepare a 1mol / L nitric acid solution as follows: clean the pipeline, pre-fill the pipeline with water, inject 470.8mL of water into the two target solution holding containers 22 (1000mL PP reagent bottles), pre-fill the pipeline with concentrated nitric acid, inject 66.7mL of concentrated nitric acid into the two target solution holding containers 22 (1000mL PP reagent bottles), and finally inject 470.8mL of water, clean the pipeline, and stir the solution. Repeat the above process to prepare the second bottle of solution.

[0142] Wherein, cleaning the pipeline includes cleaning the inner wall of the pipeline and cleaning the outer wall of the liquid inlet pipe port;

[0143] The cleaning steps of the inner wall of the pipeline are as follows: 10 ml of water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first injection channel 15 or the second injection channel 16, and air is used from the air inlet channel 10 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 to discharge the water in the channel from the first injection channel 15 or the second injection channel 16 into the waste liquid tank 37, and further flows into the waste liquid bucket 36;

[0144] The steps for cleaning the outer wall of the liquid inlet port are: water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first cleaning channel 13 or the second cleaning channel 14, the outflowing water flow flushes the first injection channel 15 or the second injection channel 16, and the waste liquid is discharged into the waste liquid tank 37 and further flows into the waste liquid barrel 36, and the flushing is continued for 5 minutes;

[0145] The steps of pre-filling the pipeline with water are as follows: injecting 12 mL of water into the water inlet channel 9 by using the first peristaltic pump 17, and using the air inlet channel 10 to discharge the water after the first multi-channel valve 19 into the waste liquid tank 37 through the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16, and further into the waste liquid tank 36;

[0146] The step of injecting 470.8 mL of water is as follows: injecting 470.8 mL of water into the water inlet channel 9 by using the first peristaltic pump 17, and injecting the water after the first multi-channel valve 19 into the target solution holding container 22 via the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by using the air inlet channel 10;

[0147] The step of pre-filling the pipeline with concentrated nitric acid is as follows: inject 12 mL of concentrated nitric acid into the water inlet channel 9 by using the first peristaltic pump 17, and discharge the concentrated nitric acid after the first multi-channel valve 19 into the waste liquid tank 37 through the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by using the air inlet channel 10, and further flow into the waste liquid tank 36;

[0148] The step of injecting 66.7 mL of concentrated nitric acid is as follows: inject 66.7 mL of the first solution to be diluted into the first solution channel 1 by using the first peristaltic pump 17, and inject the concentrated nitric acid after the first multi-channel valve 19 into the target solution holding container 22 via the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by using the air inlet channel 10;

[0149] The step of stirring the solution uniformly is: using the controller 23 to control the stirring member 34 to stir the solution at a certain speed for a certain time;

[0150] 0.1mL of the prepared solution was taken from two bottles and diluted 100 times. The pH of the diluted solution was measured by a pH meter and found to be 1.97 and 1.98 respectively. The concentrations of the prepared solutions were inferred to be 1.07 and 1.05 mol / L respectively, which were within 7% of the target solution concentration. Two bottles of 1 mol / L nitric acid solution were prepared manually using a volumetric flask, and the solution concentrations were measured by the same method to be 0.95 and 0.94 mol / L respectively.

[0151] Example 2

[0152] Based on an automatic solution preparation device and method of dilution + pH adjustment, 2 bottles of 1000mL 1mol / L nitric acid solution are prepared with concentrated nitric acid in a PP reagent bottle using a mass dilution mode.

[0153] Implementation steps: Place two target solution holding containers 22 (PP reagent bottles) on the two positioning holes 31 of the bracket 32, input the volume 1000mL, concentration 1mol / L and density 1.035g / mL of the target solution in the controller 23, and the concentration 15mol / L and density 1.4g / mL of the concentrated nitric acid solution to be diluted, and then use the mass dilution mode to prepare a 1mol / L nitric acid solution as follows: clean the pipeline, pre-fill the pipeline with water, inject 470.8g of water into the two target solution holding containers 22 (1000mL PP reagent bottles), pre-fill the pipeline with concentrated nitric acid, inject 93.3g of concentrated nitric acid into the two target solution holding containers 22 (1000mL PP reagent bottles), and finally inject 470.8g of water, clean the pipeline, and stir the solution. Repeat the above process to prepare the second bottle of solution.

[0154] Wherein, cleaning the pipeline includes cleaning the inner wall of the pipeline and cleaning the outer wall of the liquid inlet pipe port;

[0155] The cleaning steps of the inner wall of the pipeline are: 10 ml of water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first injection channel 15 or the second injection channel 16, and air is passed from the air inlet channel 10 through the first multi-channel valve 19, the dual-channel valve 21, the first peristaltic pump 17 to discharge the water in the channel from the first injection channel 15 or the second injection channel 16 into the waste liquid tank 37, and further flows into the waste liquid barrel 36. 10 ml of water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the second peristaltic pump 18 into the first injection channel 15 or the second injection channel 16, and air is passed from the air inlet channel 10 through the first multi-channel valve 19, the dual-channel valve 21, the second peristaltic pump 18 to discharge the water in the channel from the first injection channel 15 or the second injection channel 16 into the waste liquid tank 37, and further flows into the waste liquid barrel 36;

[0156] The steps for cleaning the outer wall of the liquid inlet port are: water is injected from the water inlet channel 9 through the first multi-channel valve 19, the dual-channel valve 21 and the first peristaltic pump 17 into the first cleaning channel 13 or the second cleaning channel 14, the outflowing water flow flushes the first injection channel 15 or the second injection channel 16, and the waste liquid is discharged into the waste liquid tank 37 and further flows into the waste liquid barrel 36, and the flushing is continued for 5 minutes;

[0157] The steps of pre-filling the pipeline with water are as follows: injecting 12 mL of water into the water inlet channel 9 by using the first peristaltic pump 17, and using the air inlet channel 10 to discharge the water after the first multi-channel valve 19 into the waste liquid tank 37 through the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16, and further into the waste liquid tank 36;

[0158] Among them, the step of injecting 470.8g of water is: using the first peristaltic pump 17 to inject 477mL of water into the water inlet channel 9, using the air inlet channel 10 to inject the water after the first multi-channel valve 19 into the target solution holding container 22 via the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16, and using the weighing component 33 to feed back the weighing data to the controller 23. When the mass of the injected solution is 420g, switch the second peristaltic pump 18, and water is injected into the target solution holding container 22 by the second peristaltic pump 18 via the first injection channel 15 or the second injection channel 16. When the weighing data fed back by the weighing component 33 is between 469.4g and 472.2g, the controller 23 controls the second peristaltic pump 18 to stop running;

[0159] The step of pre-filling the pipeline with concentrated nitric acid is as follows: inject 12 mL of concentrated nitric acid into the water inlet channel 9 by using the first peristaltic pump 17, and discharge the concentrated nitric acid after the first multi-channel valve 19 into the waste liquid tank 37 through the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 by using the air inlet channel 10, and further flow into the waste liquid tank 36;

[0160] Wherein, the step of injecting 93.3g of concentrated nitric acid is: injecting 43.3g of concentrated nitric acid from the first solution channel 1 to be diluted via the dual-channel valve 21, the first peristaltic pump 17, the first injection channel 15 or the second injection channel 16 into the target solution holding container 22; injecting 50g of concentrated nitric acid from the first solution channel 1 to be diluted via the dual-channel valve 21, the second peristaltic pump 18, the first injection channel 15 or the second injection channel 16 into the target solution holding container 22; the controller 23 controls the injection speed and injection amount of the concentrated nitric acid according to the data fed back by the weighing component 33; when approaching the target mass of 93.3g, the liquid injection speed is gradually reduced until the data fed back by the weighing component 33 is between 99.0g and 99.6g, and the controller 23 controls the second peristaltic pump 18 to stop running;

[0161] The step of stirring the solution uniformly is: using the controller 23 to control the stirring component 34 to stir the solution at a maximum speed for 3 minutes;

[0162] 0.1 mL of the prepared solution from each of the two bottles was diluted 100 times, and the pH of the diluted solution was measured with a pH meter, which were 2.01 and 2.00, respectively. The concentrations of the prepared solutions were inferred to be 0.98 and 1.00 mol / L, respectively.

[0163] It can be seen from Cases 1 and 2 that the volume dilution mode, manual preparation and mass dilution mode can all prepare solutions that meet the requirements, and the mass dilution mode has higher control accuracy. The concentration error of the solution prepared by the volume dilution mode is within 7%, the error of the manual preparation solution is within 5%, and the error of the mass dilution mode is within 2%.

[0164] Example 3

[0165] Based on a dilution+pH adjustment solution automatic preparation device and method, a dilution+pH adjustment mode is adopted in a 1000mL glass reagent bottle to prepare 2 bottles of 1000mL nitric acid solution with a pH of 1.05 using a 1mol / L nitric acid solution.

[0166] Implementation steps: Place two target solution holding containers 22 (1000mL glass reagent bottles) on the two positioning holes 31 of the bracket 32, input the volume 1000mL, concentration 0.089mol / L and density 1g / mL of the target solution, as well as the concentration and density 1.035g / mL of the solution to be diluted 2 (1mol / L nitric acid solution) into the controller 23, and then use the mass dilution + pH adjustment mode to prepare a nitric acid solution with a pH of 1.05 as follows: clean the pipeline, pre-fill the pipeline with water, inject 453.9g of water into the target solution holding container 22 (1000mL glass reagent bottle), pre-fill the pipeline with the solution to be diluted 2 (1mol / L nitric acid solution), inject 92.1g of 1mol / L nitric acid solution, and finally inject 453.9g of water, clean the pipeline, and stir the solution evenly.

[0167] The pH value of the target solution is initially measured to be 1.10. It is determined that the pH value does not meet the termination condition and acid needs to be used to adjust the pH. Then, the acid (3 mol / L nitric acid) is pre-filled into the pipeline. After the minimum step amount (1.5 ml) of acid is injected into the target solution container 22 through the acid channel 11, the first multi-channel valve 19, the dual-channel valve 21, the second peristaltic pump 18, the first injection channel 15 or the second injection channel 16, the solution is stirred evenly with the stirring component 34. The pH value of the solution is measured to be 1.05, which meets the termination condition. The solution is stirred evenly with the stirring component 34 and the pipeline is cleaned. Repeat the above steps to prepare the second bottle of solution.

[0168] Example 4

[0169] Based on a dilution + pH adjustment solution automatic preparation device and method, a pH adjustment mode is adopted in a 1000mL glass reagent bottle to adjust the pH of 2 bottles of 1000mL ammonium sulfate solution to 2.50 with 1mol / LH2SO4 solution.

[0170] Implementation steps: Place two target solution holding containers 22 (1000mL glass reagent bottles) on the two positioning holes 31 of the bracket 32, input the target pH value of 2.50 in the controller, and the process of adjusting the pH of the solution is as follows: Use the pH meter 27 to initially measure the pH value of the solution to be 3.71, which does not meet the pH adjustment termination condition, pre-fill the pipeline with 1mol / L H2SO4 solution, inject the minimum step amount (1.5mL) of acid into the target solution holding container 22 (1000mL glass reagent bottle) through the acid channel 11, the first multi-channel valve 19, the dual-channel valve 21, the second peristaltic pump 18, the first injection channel 15 or the second injection channel 16, stir the solution evenly with the stirring component 34, and measure the pH value of the solution to be 3.51, which does not meet the termination condition. After repeating the above pH adjustment operation 5 times, the measured pH value of the solution is 2.54, which meets the pH adjustment termination condition, stir the solution evenly with the stirring component 34 and clean the pipeline. Repeat the above steps to prepare the second bottle of solution, and adjust the pH value of the solution to 2.53.

Claims

1. A solution preparation device, characterized in that: It includes a liquid conveying mechanism (24), a positioning mechanism, a control mechanism, a cleaning mechanism, and an auxiliary mechanism; The liquid conveying mechanism (24) comprises a plurality of channels for a solution to be diluted, a water inlet channel (9), an air channel (10), an acid channel (11), an alkaline channel (12), a first cleaning channel (13), a second cleaning channel (14), a first injection channel (15), a second injection channel (16), a first peristaltic pump (17), a second peristaltic pump (18), a first multi-channel valve (19), a second multi-channel valve (20), and a dual-channel valve (21); each channel for a solution to be diluted, a water inlet channel (9), an air channel (10), an acid channel (11), an alkaline channel (12), a first cleaning channel (13), a second cleaning channel (14), a first injection channel (15), a second injection channel (16), a first peristaltic pump (17), a second peristaltic pump (18), a first multi-channel valve (19), a second multi-channel valve (20), and a dual-channel valve (21). 2) can be sequentially delivered to the target solution storage container (22) or the waste liquid tank (37) through the first multi-channel valve (19), the dual-channel valve (21), the first peristaltic pump (17) or the second peristaltic pump (18), the second multi-channel valve (20), the first injection channel (15) or the second injection channel (16); the medium delivered by the first cleaning channel (13) and the second cleaning channel (14) respectively cleans the outside of the first injection channel (15), the second injection channel (16) and the pH meter (27), and the waste liquid generated by the cleaning enters the waste liquid tank (37) and then flows into the waste liquid barrel (36); The positioning mechanism comprises a target solution holding container (22), a mechanical arm (26), a lifting frame (30), and a bracket (32); the mechanical arm (26) is mounted on the housing (25) of the auxiliary mechanism, the output end of the first injection channel (15), the output end of the second injection channel (16), and the pH meter (27) are fixed on the mechanical arm (26), and the mechanical arm (26) is controlled by a control mechanism and can move within a horizontal plane at a certain height; the pH meter (27) is used to measure the pH value of the liquid in the target solution holding container (22); the bracket (32) is fixed on the housing (25), the bracket (32) is provided with a positioning hole (31), the lifting frame (30) is located in the positioning hole (31), and the target solution holding container (22) is located on the lifting frame (30); the lifting frame (30) and the target solution holding container (22) are placed on the upper side of the stirring component (34), and the stirring component (34) is located above the weighing component (33); The cleaning mechanism comprises a waste liquid tank (37) and a waste liquid barrel (36); the waste liquid tank (37) is located inside the housing (25), and the waste liquid barrel (36) is located outside the housing (25); the liquid in the waste liquid tank (37) flows into the waste liquid barrel (36); The auxiliary mechanism comprises a pH meter (27), a weighing component (33), a stirring component (34), and a housing (25); the stirring component (34) and the weighing component (33) are integrated under the bracket (32), and the stirring component (34) is located above the weighing component (33); The control mechanism controls the rotation speed and time of the stirring component (34); the weighing component (33) and the pH meter (27) are connected to the control mechanism to transmit control signals; the weighing component (33) is used to weigh the stirring component (34), the lifting frame (30), and the target solution holding container (22).

2. The solution preparation device according to claim 1, characterized in that: The auxiliary mechanism also includes a ventilation component (29) and a lighting component (28); The ventilation component (29) is located at the rear of the housing (25) and is used to discharge the corrosive gas generated during the solution preparation process; The lighting component (28) is located at the upper part of the housing (25) and is used for lighting the solution preparation process.

3. The solution preparation device according to claim 1, characterized in that: The solution passages to be diluted are provided with 8 channels, namely a first solution passage to be diluted (1), a second solution passage to be diluted (2), a third solution passage to be diluted (3), a fourth solution passage to be diluted (4), a fifth solution passage to be diluted (5), a sixth solution passage to be diluted (6), a seventh solution passage to be diluted (7), and an eighth solution passage to be diluted (8); The first peristaltic pump (17) is used for liquid delivery at a flow rate of 10 mL / min to 200 mL / min, and the second peristaltic pump (18) is used for liquid delivery at a flow rate of 0.1 mL / min to 10 mL / min. The control mechanism controls the on and off of the first peristaltic pump (17) and the second peristaltic pump (18) as well as the volume and flow rate of the delivered liquid; The material of the to-be-diluted solution channel, the water inlet channel (9), the air channel (10), the acid solution channel (11), the alkali solution channel (12), the first injection channel (15) or the second injection channel (16) is PFA or PTFE; The control mechanism is a controller (23); The weighing component (33) is a balance with a measuring range of not less than 30 kg; the stirring component (34) is a magnetic stirring device.

4. A method for preparing a solution using the solution preparing device according to any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1, cleaning the pipeline: Cleaning the pipeline includes cleaning the inner wall of the pipeline and cleaning the outer wall of the liquid inlet pipe; Step 2, water pre-fill pipeline: Pre-filling water in the pipeline before the first multi-channel valve (19); Step 3, inject water: Add a certain volume of water into a target solution container (22); Step 4: Prefill the pipeline with the solution to be diluted: Filling the i-th solution to be diluted before the first multi-channel valve (19); Step 5, inject the solution to be diluted: Based on the solution information library, inject the solution to be diluted in volume dilution mode or mass dilution mode; A stirring component (34) is used to stir the liquid in the target solution containing container (22) until the liquid is uniform, thereby obtaining a diluted solution.

5. The method for preparing a solution according to claim 4, characterized in that: Also includes step 6, pH adjustment; Inject acid or alkali solution to adjust the pH of the existing solution, that is, pH adjustment mode. The specific process is as follows: Using a pH meter (27), initially measure the pH value of the existing solution; When the pH value of the existing solution does not meet the requirement, the adjusting liquid is judged to be an acid solution or an alkali solution is added; the adjusting liquid is pre-filled into the pipeline, the adjusting liquid is injected according to the minimum step amount, and the stirring component (34) is used to stir until it is uniform, and the pH value of the solution is measured again with a pH meter (27); It is determined again whether the adjusted pH value of the existing solution meets the termination condition. If not, the above pH adjustment operation is repeated until the adjusted pH value of the existing solution meets the requirement, thereby obtaining a pH-adjusted diluted solution.

6. The method for preparing a solution according to claim 5, characterized in that: The existing solution is a diluted solution obtained by adopting a volume dilution mode or a mass dilution mode.

7. The method for preparing a solution according to claim 5, characterized in that: The step 6 further comprises: The termination condition for determining pH adjustment is: the deviation between the measured pH value and the target pH value is within 3%; The selection basis for determining whether the regulating liquid is an acid solution or an alkaline solution is: if the measured pH value is less than the target pH value, the alkaline solution is injected through the alkaline solution channel (12); if the measured pH value is greater than the target pH value, the acid solution is injected through the acid solution channel (11); Pre-filling the regulating liquid, filling the acid or alkali solution before the first multi-channel valve (19); the specific process is: assuming that the pipeline volume of the acid channel (11) or the alkali channel (12) before the first multi-channel valve (19) is V fp0 , use the second peristaltic pump (18) to inject V into the acid channel (11) or the alkali channel (12) fp0 +2mL of acid or alkali solution, use the air inlet channel (10) to discharge the acid or alkali solution after the first multi-channel valve (19) into the waste liquid tank (37) through the dual-channel valve (21), the second peristaltic pump (18), the first injection channel (15) or the second injection channel (16), and further flow into the waste liquid barrel (36); The step size of acid or alkali solution injection is 1.5mL; The inner wall of the pipeline is cleaned, and the specific process is: 10 ml of water is injected into the first injection channel (15) or the second injection channel (16) from the acid channel (11) or the alkali channel (12) through the first multi-channel valve (19), the dual-channel valve (21) and the second peristaltic pump (18); air is used from the air inlet channel (10) through the first multi-channel valve (19), the dual-channel valve (21) and the second peristaltic pump (18) to discharge the water in the channel from the first injection channel (15) or the second injection channel (16) into the waste liquid tank (37), and further flows into the waste liquid bucket (36); The outer wall of the liquid inlet pipe opening is cleaned. The specific process is: water is passed from the water inlet channel (9) through the first multi-channel valve (19), The dual-channel valve (21) and the first peristaltic pump (17) are used to inject water into the first cleaning channel (13) or the second cleaning channel (14). The outflowing water flushes the first injection channel (15) or the second injection channel (16). The waste liquid is discharged into the waste liquid tank (37) and further flows into the waste liquid barrel (36). The flushing is continued for 5 minutes.

8. The method for preparing a solution according to claim 4, characterized in that: Also includes step 7, cleaning the pipeline again; The process of cleaning the pipeline again is the same as step 1.

9. The method for preparing a solution according to claim 4, characterized in that: In step 1, the process of cleaning the inner wall of the pipeline is: A certain amount of water is injected from the water inlet channel (9) through the first multi-channel valve (19), the dual-channel valve (21) and the first peristaltic pump (17) into the first liquid injection channel (15) or the second liquid injection channel (16); air is injected from the air inlet channel (10) through the first multi-channel valve (19), the dual-channel valve (21) and the first peristaltic pump (17) to discharge the water in the channel from the first liquid injection channel (15) or the second liquid injection channel (16) into the waste liquid tank (37), and further into the waste liquid bucket (36); In step 1, the process of cleaning the outer wall of the liquid inlet pipe opening is: Water is injected from the water inlet channel (9) into the first cleaning channel (13) or the second cleaning channel (14) through the first multi-channel valve (19), the dual-channel valve (21) and the first peristaltic pump (17), the outflowing water flow flushes the first injection channel (15) or the second injection channel (16), and the waste liquid is discharged into the waste liquid tank (37) and further flows into the waste liquid barrel (36); In step 2, the process of pre-filling the pipeline with water is: Fill the water before the first multi-channel valve (19), assuming that the volume of the water inlet channel (9) before the first multi-channel valve (19) is V f0 , use the first peristaltic pump (17) to add V into the water inlet channel (9) f0 +2mL of water, use the air inlet channel (10) to discharge the water after the first multi-channel valve (19) into the waste liquid tank (37) through the dual-channel valve (21), the first peristaltic pump (17), the first injection channel (15) or the second injection channel (16), and further flow into the waste liquid barrel (36); In step 3, the process of injecting water is: If the volume of water injected is V r >50mL, add V to the water inlet channel (9) using the first peristaltic pump (17) r of water, Using the air inlet channel (10), water after the first multi-channel valve (19) is injected into the target solution storage container (22) via the dual-channel valve (21), the first peristaltic pump (17), the first injection channel (15) or the second injection channel (16); If the volume of water injected is V r ≤50mL, add V into the water inlet channel (9) using the second peristaltic pump (18). r water, using the air inlet channel (10) to inject the water after the first multi-channel valve (19) into the target solution storage container (22) via the dual-channel valve (21), the second peristaltic pump (18), the first injection channel (15) or the second injection channel (16); In step 4, the specific process of pre-filling the pipeline with the solution to be diluted is: Assume that the volume of the pipeline of the i-th to-be-diluted solution channel i before the first multi-channel valve (19) is V fi0 , use the first peristaltic pump (17) to add V into the water inlet channel (9) fi0 +2mL of the i-th solution to be diluted, the i-th solution to be diluted after the first multi-channel valve (19) is discharged into the waste liquid tank (37) through the double-channel valve (21), the first peristaltic pump (17), the first injection channel (15) or the second injection channel (16) by the air inlet channel (10), and further flows into the waste liquid barrel (36); in the step 5, the volume dilution mode, the injection amount is controlled according to the volume of the solution to be diluted, and the solution to be diluted is injected, and the injection process is: If the volume of the diluted solution V is injected i >50mL, use the first peristaltic pump (17) to add V to the i-th channel of the solution to be diluted i The i-th solution to be diluted is injected into the target solution storage container (22) through the air inlet channel (10) via the dual-channel valve (21), the first peristaltic pump (17), the first injection channel (15) or the second injection channel (16); If the volume of the diluted solution V is injected i ≤50mL, use the second peristaltic pump 17 to add V to the i-th channel of the solution to be diluted i The i-th solution to be diluted is injected into the target solution storage container (22) through the air inlet channel (10) via the dual-channel valve (21), the second peristaltic pump (18), the first injection channel (15) or the second injection channel (16); In step 5, in the mass dilution mode, the injection amount is controlled according to the mass of the solution to be diluted, and the solution to be diluted is injected. The specific process is: If the mass of the diluted solution injected is m i >50g, the first peristaltic pump (17) is used; if the mass of the solution to be diluted is m i When ≤50g, a second peristaltic pump (18) is used; m is added to the i-th channel i of the solution to be diluted. i / ρ i +5mL of the i-th solution to be diluted, the i-th solution to be diluted after the first multi-channel valve (19) is injected into the target solution holding container (22) through the air inlet channel (10) via the dual-channel valve (21), the first peristaltic pump (17) or the second peristaltic pump (18), the first injection channel (15) or the second injection channel (16), and the control mechanism controls the injection speed and injection amount of the i-th solution to be diluted according to the data fed back by the weighing component (33). When the target mass differs by 50g, the first peristaltic pump (17) is switched to the second peristaltic pump (18) through the dual-channel valve (21). When approaching the target mass, the liquid injection speed is gradually reduced until the data fed back by the weighing component (33) is consistent with the m i When the deviation is within 0.3%, the control mechanism controls the second peristaltic pump (18) to stop running.

10. The method for preparing a solution according to claim 4, characterized in that: In step 1, 10 ml of water is used to clean the inner wall of the pipeline and the outer wall of the liquid inlet nozzle, and the outer wall of the liquid inlet nozzle is cleaned for 5 minutes; In step 3 and step 4, the first peristaltic pump (17) or the second peristaltic pump (18) is used to inject the added volume of water or the solution i to be diluted, and the control mechanism controls the number of steps of the first peristaltic pump (17) or the second peristaltic pump (18); In step 5, the solution information library includes density ρ and molar concentration c information of the solution to be diluted, the solvent and the target solution.

Images