A pathological section anti-curling device and a full-automatic frozen section pasting equipment

Abstract

The application relates to the technical field of pathological section anti-winding structures, and particularly provides a pathological section anti-winding device and a full-automatic frozen section pasting equipment. The pathological section anti-winding device comprises a conveying assembly, a multi-micropore conveying belt is arranged, and the multi-micropore conveying belt is used for adsorbing pathological sections; an adsorption assembly is connected with the conveying assembly and is used for controlling the multi-micropore conveying belt to provide a negative pressure suction force for adsorbing pathological sections; a glass cover plate is arranged above the multi-micropore conveying belt and is used for flattening pathological sections in cooperation with the multi-micropore conveying belt; the multi-micropore conveying belt has a conveying stroke, the conveying stroke has an anti-winding adsorption area and a pasting and discharging area, the glass cover plate is arranged on the anti-winding adsorption area and is arranged in flush with an end of the anti-winding adsorption area which is away from the pasting and discharging area, and pathological sections enter the multi-micropore conveying belt from the end of the anti-winding adsorption area which is away from the pasting and discharging area. The pathological section anti-winding device avoids the winding problem of pathological sections and guarantees the efficiency and quality of pathological sections.

Description

Technical Field

[0001] This application relates to the field of anti-rolling structure technology for pathological slides, and in particular to an anti-rolling device for pathological slides and a fully automatic cryosection mounting device. Background Technology

[0002] Pathological section examination is a crucial foundational tool in biomedical research and clinical diagnosis. Through steps such as sampling, fixation, embedding, sectioning, and staining, operators can observe cells and tissues to determine the nature and extent of diseases. The quality of the sections is of paramount importance for subsequent pathological analysis and diagnosis; even minor defects or wrinkles can affect the accuracy of subsequent analysis and diagnosis. In current section preparation processes, section curling is a frequent problem. Section curling affects the imaging quality of microscopic observation, leading to an inability to accurately determine the type and extent of lesions. If section curling occurs in certain critical sections, it can result in the damage and loss of crucial data, hindering a comprehensive diagnosis and analysis. Therefore, preventing section curling is of utmost importance in clinical pathological examination.

[0003] Existing anti-roll technology typically uses an anti-roll glass cover to control the curling of the slicing blade. Its main principle is to limit curling during the cutting process by adjusting the gap between the anti-roll glass cover and the blade. To achieve the ideal anti-rolling effect, operators need to precisely adjust the anti-roll glass cover before use to ensure the gap is optimal. However, this anti-rolling method requires a high level of operator experience, and the adjustment process is relatively cumbersome. If the adjustment is not precise, such as if the gap is too large, the slicing will still curl, failing to meet actual production needs. Furthermore, during the placement process, the anti-roll glass cover often needs to be opened first to remove the gap restriction, which may cause the already cut slicing blade to curl again.

[0004] In summary, existing anti-roll technology based on anti-roll glass covers has significant limitations in terms of operability and efficiency. On the one hand, repeated adjustments and operations of the glass cover increase time and labor costs; on the other hand, once the glass cover is open, it cannot maintain effective restriction on the slicing process continuously, affecting slicing quality and mounting efficiency. Therefore, there is an urgent need for an improved solution that enhances anti-rolling effectiveness while being easier to operate and providing continuous effective restriction on the slicing process. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the purpose of this application is to provide a pathological slide anti-curling device and a fully automatic frozen slide mounting device, which aims to solve the problems in the prior art where repeated adjustment and operation of the glass cover during the preparation of pathological slides easily increases time and labor costs; at the same time, when removing the slide, the glass cover needs to be opened, which cannot maintain effective restriction of the slide, thus affecting the slide quality and mounting efficiency.

[0006] The technical solution adopted by this application to solve the technical problem is as follows: a pathological slide anti-curling device for a fully automatic cryosection mounting device, comprising:

[0007] A conveying assembly is provided with a microporous conveyor belt, which is used to adsorb and receive pathological slides.

[0008] An adsorption component, connected to the conveying component, is used to control the multi-microporous conveyor belt to provide negative pressure suction for adsorbing pathological slides.

[0009] A glass cover plate is disposed above the multi-microporous conveyor belt to help the multi-microporous conveyor belt flatten the pathological slides.

[0010] The multi-microporous conveyor belt has a conveying stroke, which includes an anti-roll-up adsorption area and a patch feeding area. The glass cover is disposed on the anti-roll-up adsorption area and is flush with the end of the anti-roll-up adsorption area away from the patch feeding area. The pathological slide enters the multi-microporous conveyor belt from the end of the anti-roll-up adsorption area away from the patch feeding area.

[0011] Optionally, the ratio of the extension length of the patch feeding area to the anti-roll adsorption area is 0.2-0.3.

[0012] Optionally, the pore size of the micropore structure on the multi-micropore conveyor belt is set to 0.1mm-0.8mm.

[0013] Optionally, the multi-microporous conveyor belt has a width direction perpendicular to the conveying direction; in the width direction, the micropore distribution density on the multi-microporous conveyor belt is uniformly distributed; or, in the width direction, the micropore distribution density on the multi-microporous conveyor belt decreases from the middle to the two edges.

[0014] Optionally, the conveying surface of the multi-microporous conveyor belt is provided with an anti-stick coating.

[0015] Optionally, the conveying assembly further includes a stepper motor, a drive shaft, and a driven shaft. The drive shaft is connected to the stepper motor, and the multi-micro-perforated conveyor belt is sleeved on the drive shaft and the driven shaft. The stepper motor and the drive shaft are located at one end of the patch feeding area away from the anti-winding adsorption area, and the driven wheel is located at one end of the anti-winding adsorption area away from the patch feeding area.

[0016] Optionally, the adsorption component includes:

[0017] Negative pressure pump;

[0018] A negative pressure box is connected to a negative pressure pump and is disposed in the gap of the multi-microporous conveyor belt. The negative pressure box is provided with a multi-porous top cover, and a fitting gap is provided between the multi-porous top cover and the multi-microporous conveyor belt. The negative pressure pump draws air from the negative pressure box and forms a negative pressure on the surface of the multi-microporous conveyor belt through the multi-porous top cover.

[0019] The technical solution adopted by this application to solve the technical problem is as follows: a fully automatic cryosection mounting device, which includes the pathological slide anti-curling device as described above.

[0020] Optionally, the fully automatic cryosection mounting equipment further includes a moving blade changing assembly, a coarse adjustment feed assembly, a blade holder adjustment platform, a blade holder, and a cutting blade; the coarse adjustment feed assembly is vertically mounted on the moving blade changing assembly; the blade holder adjustment platform is mounted on the coarse adjustment feed assembly; the cutting blade is mounted on the blade holder; the blade holder and the pathological slide anti-curling device are both mounted on the blade holder adjustment platform; and the blade holder is located at the end of the glass cover plate aligned with the end of the multi-microporous conveyor belt; the extending direction of the cutting blade is parallel to the moving blade changing assembly.

[0021] Optionally, the tool holder adjustment platform includes:

[0022] A platform support is mounted on the coarse adjustment feed assembly, and the platform support is provided with an arc-shaped top seat;

[0023] The support platform is provided with an arc-shaped base that is rotatably mounted on the platform support. The blade holder and the pathological slide anti-curling device are both mounted on the support platform.

[0024] An angle adjustment component is disposed on the arc-shaped top seat and connected to the arc-shaped base via the arc-shaped top seat. It is used to adjust the pitch angle of the support platform to adjust the pitch angle of the cutting blade.

[0025] Compared with existing technologies, this application provides a pathological slide anti-curling device and a fully automatic cryosection mounting device. The anti-curling device comprises a conveying component and an adsorption component, with a multi-microporous conveyor belt on the conveying component. The adsorption component creates a negative pressure adsorption environment on the multi-microporous conveyor belt, fixing the pathological slide to the surface of the multi-microporous conveyor belt before it completely leaves the blade area, thus preventing curling upon detachment. The multi-microporous conveyor belt is divided into an anti-curling adsorption zone and a mounting and unloading zone, and the anti-curling... A glass cover is installed above the roll adsorption area. Through the combined action of the glass cover and the anti-roll adsorption area, the slides can be flattened and adsorbed under negative pressure at the beginning of slide formation, ensuring the flatness of the slide surface. At the same time, by aligning the ends of the glass cover and the anti-roll adsorption area away from the slide loading area, the pathological slides are restrained by the glass cover and the multi-microporous conveyor belt when they partially detach from the blade, further reducing the possibility of curling. Meanwhile, after the slides pass through the slide loading area, they can be directly mounted without having to open the cover again for adjustment, effectively improving mounting efficiency. Attached Figure Description

[0026] Figure 1 This is a three-dimensional structural schematic diagram of the pathological slide anti-curling device provided in this application;

[0027] Figure 2 This is a three-dimensional structural schematic diagram of the pathological slide anti-curling device provided in this application from another perspective;

[0028] Figure 3 This is a three-dimensional exploded structural diagram of the pathological slide anti-curling device provided in this application;

[0029] Figure 4 This is a three-dimensional schematic diagram of the cooperation relationship between the pathological slide anti-rolling device, the blade holder and the cutting blade of the fully automatic cryosection mounting equipment provided in this application;

[0030] Figure 5 It is provided in this application Figure 3 Enlarged structural diagram at point A in the middle;

[0031] Figure 6 This is a three-dimensional structural diagram of the fully automated cryosectioning and mounting device provided in this application;

[0032] Figure 7 This is a side view schematic diagram of the fully automated cryosectioning and mounting equipment provided in this application;

[0033] Figure 8 This is a side view schematic diagram from another perspective of the fully automated cryosectioning and mounting device provided in this application;

[0034] Explanation of reference numerals in the attached figures:

[0035] 1. Fully automatic cryosectioning and mounting equipment; 10. Pathological slide anti-curling device; 20. Moving blade changing assembly; 30. Coarse adjustment feed assembly; 40. Blade holder adjustment platform; 50. Blade holder; 60. Cutting blade; 11. Conveying assembly; 12. Adsorption assembly; 13. Glass cover plate; 111. Multi-microporous conveyor belt; 112. Conveying stroke; 113. Anti-curling adsorption zone; 114. Slide unloading zone; 115. Microporous structure; 116. Anti-stick coating; 117. Stepper motor; 118. Drive shaft; 119. Driven shaft; 121. Negative pressure box; 122. Multi-hole top cover; 41. Platform support; 42. Bearing platform; 43. Angle adjustment component; 411. Arc-shaped top seat; 421. Arc-shaped base. Detailed Implementation

[0036] The embodiments of this application are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this application, and should not be construed as limiting this application.

[0037] In the description of this application, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this application. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more.

[0038] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0039] Please refer to the following: Figures 1 to 4The first embodiment of this application provides a pathological slide anti-curling device 10 for a fully automatic cryo-slide mounting device 1. It mainly prevents the pathological slides from curling when the fully automatic cryo-slide mounting device 1 cuts the frozen pathological samples to obtain pathological slides, thereby reducing the time and labor costs of pathological slide production, while improving the quality of pathological slides and mounting efficiency.

[0040] The pathological slide anti-curling device 10 includes a conveying assembly 11, an adsorption assembly 12, and a glass cover plate 13. The conveying assembly 11 is equipped with a multi-microporous conveyor belt 111, which is used to adsorb and receive pathological slides. The adsorption assembly 12 is connected to the conveying assembly 11 and is used to control the multi-microporous conveyor belt 111 to provide negative pressure suction for adsorbing pathological slides. The glass cover plate 13 is disposed above the multi-microporous conveyor belt 111 and is used to cooperate with the multi-microporous conveyor belt 111. The conveyor belt 111 flattens the pathological slides; wherein, the multi-microporous conveyor belt 111 has a conveying stroke 112, the conveying stroke 112 has an anti-winding adsorption area 113 and a slide unloading area 114, the glass cover plate 13 is disposed on the anti-winding adsorption area 113 and is flush with the end of the anti-winding adsorption area 113 away from the slide unloading area 114, and the pathological slides enter the multi-microporous conveyor belt 111 from the end of the anti-winding adsorption area 113 away from the slide unloading area 114.

[0041] It is understood that the pathological slide anti-curling device 10, by setting up a conveying component 11 and an adsorption component 12, and by setting a multi-microporous conveyor belt 111 on the conveying component 11, and by creating a negative pressure adsorption environment on the multi-microporous conveyor belt 111 through the adsorption component 12, can fix the pathological slide on the surface of the multi-microporous conveyor belt 111 before the slide has completely left the blade area, thus preventing the slide from curling at the moment of detachment from the blade; by dividing the multi-microporous conveyor belt 111 into two conveying strokes 112, namely an anti-curling adsorption zone 113 and a slide loading zone 114, and by setting a glass cover above the anti-curling adsorption zone 113, the device can prevent the slide from curling. The plate 13, through the combined action of the glass cover plate 13 and the anti-curling adsorption area 113, can flatten and adsorb the slide at the beginning of slide formation, ensuring the flatness of the slide surface. Simultaneously, by aligning the ends of the glass cover plate 13 and the anti-curling adsorption area 113 with the ends away from the slide loading area 114, the pathological slide is restrained by the glass cover plate 13 and the multi-microporous conveyor belt 111 when it partially detaches from the blade, further reducing the possibility of curling. At the same time, after the slide passes through the slide loading area 114, it can be directly mounted without opening the cover plate for adjustment, effectively improving mounting efficiency. Furthermore, by flexibly controlling the negative pressure of the adsorption component 12, it can adapt to pathological slides of different thicknesses or materials, avoiding insufficient or excessive localized suction during transport by the multi-microporous conveyor belt 111, thus balancing the needs of good anti-curling effect, operational convenience, and pathological slide quality.

[0042] In some embodiments, the ratio of the extension length of the patch feeding area 114 to the anti-curling adsorption area 113 is 0.2-0.3. It is understood that the extension length of the glass cover plate 13 is set to be the same as the extension length of the anti-curling adsorption area 113, allowing patch application without removing the glass cover plate 13. This eliminates the need to remove the glass cover plate 13 after each slice and to readjust the gap between the glass cover plate 13 and the cutting blade 60 when cutting a second slice, thus effectively improving the cutting efficiency of pathological sections. When the proportion of the anti-curling adsorption area 113 is too small (less than 0.2), the extension length of the anti-curling adsorption area 113 is too long, leading to over-adsorption of the pathological section and potential breakage. Insufficient length of the patch feeding area 114 results in insufficient space for patch feeding, reducing patch application efficiency. When the proportion of the anti-curling adsorption area 113 is too large (greater than 0.3), the pathological section may enter the patch feeding area 114 rapidly before being fully adsorbed and flattened, potentially increasing the risk of curling.

[0043] Please refer to the following: Figure 5In some embodiments, the pore size of the microporous structure 115 on the multi-microporous conveyor belt 111 is set to 0.1mm-0.8mm. To achieve better negative pressure adsorption and good adhesion of pathological slides on the multi-microporous conveyor belt 111, the pore size of the microporous structure 115 is controlled between 0.1mm and 0.8mm. If the pore size is too large, excessive local negative pressure suction may damage the pathological slides; if the pore size is too small, the processing difficulty increases exponentially and insufficient suction may occur. Setting the pore size within the range of 0.1mm-0.8mm not only meets the high negative pressure adsorption requirements but also ensures the strength and durability of the conveyor belt, thereby effectively preventing the pathological slides from curling or shifting during slide transport and mounting.

[0044] In some embodiments, the multi-microporous conveyor belt 111 has a width direction perpendicular to the conveying direction; in the width direction, the micropores on the multi-microporous conveyor belt 111 are evenly distributed; this allows the entire conveyor belt to obtain a relatively uniform negative pressure adsorption force within its width range, ensuring that each transverse area of ​​the pathological slide receives a relatively balanced compression effect, thereby reducing local wrinkles or curling. Simultaneously, it can also be used in conjunction with the movement and switching of the cutting position of the cutting blade 60 to avoid the problem of poor pathological slide quality caused by excessive local wear of the cutting blade 60.

[0045] In some embodiments, the multi-microporous conveyor belt 111 has a width direction perpendicular to the conveying direction; in the width direction, the micropore distribution density on the multi-microporous conveyor belt 111 decreases from the middle to the two edges. The middle region, due to the concentration of more micropores, forms a relatively stronger negative pressure adsorption region, which helps the slice to be firmly adsorbed in the center; the lower density at the two edges prevents material deformation caused by excessive suction, and also facilitates a certain degree of automatic flattening of the slice during conveying at the edges, thereby achieving an adsorption effect that is both stable and flexible.

[0046] In some embodiments, the conveying surface of the multi-microporous conveyor belt 111 is provided with an anti-stick coating 116. This further reduces the risk of adhesion of pathological slides during the conveying process and facilitates the transfer and cleaning of pathological slides. The anti-stick coating 116 can be made of a wear-resistant, chemically inert material with controllable hydrophilicity / hydrophobicity (such as Teflon coating, silicon-based coating, etc.), thereby forming a low-adhesion interface between the pathological slides and the conveying surface. On the one hand, the pathological slides can maintain a good flattened state while being adsorbed under negative pressure, preventing tearing or deformation of the pathological slides due to excessive local adhesion; on the other hand, cleaning the conveyor belt surface and subsequent replacement operations are more convenient after the slide mounting operation, reducing the possibility of material residue and cross-contamination, and improving the efficiency and stability of the entire pathological slide processing flow.

[0047] Please continue to refer to the following: Figure 1 , Figure 3 and Figure 4 In some embodiments, the conveying assembly 11 further includes a stepper motor 117, a drive shaft 118, and a driven shaft 119. The drive shaft 118 is connected to the stepper motor 117. The multi-micro-perforated conveyor belt 111 is sleeved on the drive shaft 118 and the driven shaft 119. The stepper motor 117 and the drive shaft 118 are located at one end of the patch feeding area 114 away from the anti-winding adsorption area 113. The driven wheel is located at one end of the anti-winding adsorption area 113 away from the patch feeding area 114. It can be seen that the conveying assembly 11 is driven by the stepper motor 117 to rotate the drive shaft 118, thereby pulling the multi-micro-perforated conveyor belt 111 for uniform or step-by-step conveying. The driven shaft 119 is located at the other end opposite to the drive shaft 118 and is used for tensioning and guiding the conveyor belt. Specifically, the stepper motor 117 and the drive shaft 118 are positioned at the end of the chip feeding area 114 away from the anti-winding adsorption area 113, and the cutting blade 60 is located at the end of the anti-winding adsorption area 113 away from the chip feeding area 114. This arrangement facilitates proper separation between the slicing area and the transmission mechanism, reducing contamination or interference to the transmission mechanism during the slicing process. Simultaneously, the driven shaft 119, located at the end of the anti-winding adsorption area 113 away from the chip feeding area 114, provides a more stable belt tension at the initial adsorption position of the slice, ensuring that the slice is quickly and reliably adsorbed and flattened when it enters the conveyor belt after cutting. This layout results in a smoother conveying process, higher work efficiency, and easier daily cleaning and maintenance.

[0048] Please continue to refer to the following: Figure 4In some embodiments, the adsorption component 12 includes a negative pressure pump and a negative pressure box 121; the negative pressure box 121 is connected to the negative pressure pump, and is disposed in the gap of the multi-microporous conveyor belt 111. The negative pressure box 121 is provided with a porous top cover 122, and a fitting gap is provided between the porous top cover 122 and the multi-microporous conveyor belt 111. It can be seen that a closed or semi-closed space is formed in the area close to the conveyor belt. After the air is drawn out by the negative pressure pump, it can provide a concentrated and controllable negative pressure suction to the multi-microporous conveyor belt 111, avoiding adsorption pressure fluctuations caused by external interference; the negative pressure pump draws air from the negative pressure box 121. The air in the vacuum pump is drawn away through the porous top cover 122 to form a negative pressure on the surface of the microporous conveyor belt 111. The negative pressure pump can stably provide a negative pressure source during the operation of the pathological slide anti-curling device 10, and form a negative pressure environment on the microporous conveyor belt 111 through the negative pressure box 121, so that the adsorption force of the pathological slide on the microporous conveyor belt 111 is reliably guaranteed. Specifically, when the negative pressure pump continuously pumps air, the air will be drawn away through the pores on the porous top cover 122, thereby forming a uniform and moderate negative pressure area on the surface of the microporous conveyor belt 111. At the same time, the gap can maintain the adsorption strength while avoiding excessive friction or interference to the conveyor belt.

[0049] Please refer to the following: Figure 4 , Figure 6 , Figure 7 and Figure 8 The second embodiment of this application also provides a fully automated cryosection mounting device 1, which includes a pathological slide anti-curling device 10 as described in the first embodiment of this application. This effectively ensures that the fully automated cryosection mounting device 1 can prevent pathological slides from curling during cutting and improves the cutting efficiency of pathological slides.

[0050] In some embodiments, the fully automatic cryosection mounting device 1 further includes a moving blade changing assembly 20, a coarse adjustment feed assembly 30, a blade holder adjustment platform 40, a blade holder 50, and a cutting blade 60; the moving blade changing module is a single-axis linear module driven by a servo motor, which can assist the cutting blade 60 in moving left and right, so that the cutting blade 60 can be used evenly, improving the utilization rate of the cutting blade 60 and ensuring the cutting efficiency and quality of the pathological sections; the coarse adjustment feed assembly 30 is vertically arranged on the moving blade changing assembly 20, and the coarse adjustment feed module is a single-axis linear module driven by a servo motor, which can adjust the distance between the cutting blade 60 and the frozen pathological sample; when the section is ready, the coarse adjustment feed module needs to position the cutting blade 60 on the plane to be cut of the frozen pathological sample; after the pathological section is completed When it is necessary to change to a frozen pathological sample, the coarse adjustment feed module needs to be adjusted so that the cutting blade 60 is away from the frozen pathological sample, so as to leave enough space for the robotic arm to change to a new frozen tissue block. The blade holder adjustment platform 40 is set on the coarse adjustment feed assembly 30, and the cutting blade 60 is set on the blade holder 50. The blade holder 50 and the pathological slide anti-curling device 10 are both set on the blade holder adjustment platform 40. The blade holder adjustment platform 40 is the platform for adjusting the angle, so as to realize the adjustment of the pitch angle of the cutting blade 60, which is convenient for roughly adjusting the cutting angle of the cutting blade 60 when preparing the cutting slide. The blade holder 50 is also located at the end of the glass cover plate 13 that is aligned with the end of the multi-microporous conveyor belt 111. The extension direction of the cutting blade 60 is parallel to the moving blade changing assembly 20.

[0051] When cutting pathological sections, upon starting the equipment, the movable blade changing assembly 20 is positioned first, while the coarse adjustment feed assembly 30 moves the blade holder adjustment platform 40 to the predetermined position. The cutting blade 60 is fixed on the blade holder 50, aligned with the ends of the multi-microporous conveyor belt 111 and the glass cover plate 13. After the pathological tissue is fed into the cutting area under frozen conditions, the sectioning process begins immediately. The cut pathological sections fall onto the multi-microporous conveyor belt 111 of the pathological section anti-curling device 10 immediately, and are subjected to negative pressure adsorption and the synergistic effect of the glass cover plate 13, reducing the curling that may occur when the blade separates from the section. Subsequently, the flat section is driven by the stepper motor 117 to the mounting and unloading area 114 for mounting, significantly improving the overall efficiency and section quality of the fully automatic cryopreservation and mounting equipment 1.

[0052] In some embodiments, the blade holder adjustment platform 40 includes: a platform support 41, a support platform 42, and an angle adjustment component 43; the platform support 41 is disposed on the coarse adjustment feed assembly 30, and the platform support 41 is provided with an arc-shaped top seat 411; the support platform 42 is provided with an arc-shaped base 421 rotatably disposed on the platform support 41, which can be finely adjusted in pitch angle around the arc-shaped top seat 411; the blade holder 50 and the pathological slide anti-curling device 10 are both disposed on the support platform 42, thereby maintaining precise alignment between the cutting blade 60 and the anti-curling conveying area;

[0053] The angle adjustment component 43 is disposed on the arc-shaped top seat 411 and connected to the arc-shaped base 421 through the arc-shaped top seat 411. It is used to adjust the pitch angle of the support platform 42, thereby adjusting the pitch angle of the cutting blade 60. By connecting the arc-shaped top seat 411 and the arc-shaped base 421 through the angle adjustment component 43, when the operator or system applies a fine-tuning command to the angle adjustment component 43, the support platform 42 can perform up-and-down pitching movements to change the pitch angle of the cutting blade 60, thus adapting to the needs of pathological slides of different thicknesses or hardnesses, ensuring slide flatness and cutting efficiency, and achieving multi-directional precise positioning of the cutting blade 60 and the pathological slide anti-curling device 10.

[0054] In summary, this application provides a pathological slide anti-curling device and a fully automatic cryopreservation slide mounting device. The pathological slide anti-curling device includes: a conveying component, which is provided with a multi-microporous conveyor belt for adsorbing and receiving pathological slides; an adsorption component, which is connected to the conveying component and is used to control the multi-microporous conveyor belt to provide negative pressure suction for adsorbing pathological slides; and a glass cover plate, which is disposed above the multi-microporous conveyor belt and is used to cooperate with the multi-microporous conveyor belt to flatten the pathological slides; wherein, the multi-microporous conveyor belt has a conveying stroke, which has an anti-curling adsorption area and a slide loading area, and the glass cover plate is disposed on the anti-curling adsorption area and is flush with the end of the anti-curling adsorption area away from the slide loading area, and the pathological slide enters the multi-microporous conveyor belt from the end of the anti-curling adsorption area away from the slide loading area. The pathological slide anti-curling device incorporates a conveying component and an adsorption component. The conveying component features a multi-microporous conveyor belt, and the adsorption component creates a negative pressure adsorption environment on the belt. This allows the pathological slide to be fixed to the surface of the conveyor belt before it completely leaves the blade area, preventing curling upon detachment. The multi-microporous conveyor belt is divided into an anti-curling adsorption zone and a slide preparation zone. A glass cover is placed above the anti-curling adsorption zone. The combined action of the glass cover and the anti-curling adsorption zone flattens and applies negative pressure adsorption to the slide at the initial stage of slide formation, ensuring a smooth surface. Furthermore, by aligning the glass cover with the end of the anti-curling adsorption zone away from the slide preparation zone, the slide is restrained by both the glass cover and the multi-microporous conveyor belt when it partially detaches from the blade, further reducing the possibility of curling. Simultaneously, slides can be directly prepared for slide preparation after passing through the slide preparation zone without needing to open the cover again for adjustment, effectively improving preparation efficiency.

[0055] It should be understood that the application of this application is not limited to the examples above. Those skilled in the art can make improvements or modifications based on the above description, and all such improvements and modifications should fall within the protection scope of the appended claims.

Claims

1. A pathology section anti-curling device for a fully automated cryosectioning patching apparatus, characterized in that, The device comprises: a conveying assembly provided with a multi-micropore conveying belt for adsorbing pathological sections; the multi-micropore conveying belt has a width direction perpendicular to the conveying direction; in the width direction, the micropores on the multi-micropore conveying belt are uniformly distributed; or in the width direction, the micropore distribution density on the multi-micropore conveying belt decreases from the middle to the edges; an adsorption assembly connected with the conveying assembly for controlling the negative pressure suction force of the multi-micropore conveying belt for adsorbing pathological sections; wherein the size of the negative pressure suction force of the adsorption assembly is adjustable; a glass cover plate arranged above the multi-micropore conveying belt for flattening pathological sections with the multi-micropore conveying belt; a cutting blade; wherein the multi-micropore conveying belt has a conveying stroke, the conveying stroke has an anti-winding adsorption area and a patch unloading area, the glass cover plate is arranged on the anti-winding adsorption area and is flush with the end of the anti-winding adsorption area away from the patch unloading area, the cutting blade is located at the end of the anti-winding adsorption area away from the patch unloading area, and the pathological sections enter the multi-micropore conveying belt from the end of the anti-winding adsorption area away from the patch unloading area.

2. The pathology slide anti-roll device of claim 1, wherein, The extension length ratio of the patch unloading area and the anti-winding adsorption area is 0.2-0.

3.

3. The pathology slide anti-roll device of claim 1, wherein, The pore diameter of the micropore structure on the multi-micropore conveying belt is 0.1mm-0.8mm.

4. The pathology slide anti-roll device of claim 1, wherein, The conveying surface of the multi-micropore conveying belt is provided with an anti-sticking coating.

5. The pathology slide anti-roll device of claim 1, wherein, The conveying assembly further comprises a stepping motor, a driving shaft and a driven shaft, the driving shaft is connected with the stepping motor, the multi-micropore conveying belt is sleeved on the driving shaft and the driven shaft, and the stepping motor and the driving shaft are located at one end of the patch unloading area away from the anti-winding adsorption area, and the driven shaft is arranged at one end of the anti-winding adsorption area away from the patch unloading area.

6. The pathology slide anti-roll device of claim 1, wherein, The adsorption assembly comprises: a negative pressure pump; a negative pressure box connected with the negative pressure pump, the negative pressure box is arranged in the gap of the multi-micropore conveying belt, the negative pressure box is provided with a multi-hole top box cover, and a matching gap is arranged between the multi-hole top box cover and the multi-micropore conveying belt; the negative pressure pump sucks air in the negative pressure box and forms a negative pressure on the surface of the multi-micropore conveying belt through the multi-hole top box cover.

7. A fully automated cryostat sectioning patch device, characterized in that The device comprises a pathological section anti-winding device as claimed in any one of claims 1-6.

8. The fully automated cryostat sectioning patch device of claim 7, wherein, The fully automatic frozen section patch equipment further comprises a moving blade changing assembly, a coarse adjustment feeding assembly, a blade holder adjusting platform and a blade fixing frame; the coarse adjustment feeding assembly is vertically arranged on the moving blade changing assembly; the blade holder adjusting platform is arranged on the coarse adjustment feeding assembly, the cutting blade is arranged on the blade fixing frame, the blade fixing frame and the pathological section anti-winding device are arranged on the blade holder adjusting platform, and the blade fixing frame is located at one end of the glass cover plate and the end of the multi-micropore conveying belt, and the extension direction of the cutting blade is parallel to the moving blade changing assembly.

9. The fully automated cryostat sectioning patch device of claim 8, wherein, The blade holder adjusting platform comprises: A platform support is arranged on the coarse feed assembly, and is provided with a circular arc top seat; A bearing platform is provided with a circular arc bottom seat arranged on the platform support, and the blade fixing frame and the pathological section anti-winding device are arranged on the bearing platform; An angle adjusting member is arranged on the circular arc top seat and connected with the circular arc bottom seat through the circular arc top seat, and is used for adjusting the pitch angle of the bearing platform to adjust the pitch angle of the cutting blade.

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