Double two-dimensional online solid-phase extraction valve cutting device

Abstract

The invention provides a double-two-dimensional online solid-phase extraction valve cutting device, which belongs to the technical field of sample analysis, and is characterized in that a first fluid channel provided with a first SPE small column and a second fluid channel provided with a second SPE small column are formed by virtue of a first multi-way valve; a third fluid channel provided with a first chromatographic column and a fourth fluid channel provided with a second chromatographic column are formed by means of a second multi-way valve; in the first state, the first fluid channel enables the first SPE small column to perform sample elution, and the second fluid channel enables the second SPE small column to perform sample enrichment; the third fluid channel enables the first chromatographic column to perform sample chromatographic separation operation; in the second state, the second fluid channel enables the second SPE small column to perform sample elution, the first fluid channel enables the first SPE small column to perform sample enrichment, and the fourth fluid channel enables the second chromatographic column to perform sample chromatographic separation operation. Through design of a two-dimensional extraction system and introduction of an automatic control technology, high efficiency, automation and intelligentization of sample pretreatment are realized.

Description

Technical Field

[0001] The invention relates to the technical field of sample analysis, and in particular to a dual-two-dimensional online solid phase extraction valve cutting device. Background Art

[0002] Sample pretreatment technology mainly relies on traditional liquid-liquid extraction, offline solid phase extraction (SPE), and online single two-dimensional chromatography systems. These technical solutions meet the needs of analytical testing to a certain extent, but they also have obvious shortcomings and limitations.

[0003] 1. Liquid-liquid extraction technology Liquid-liquid extraction is a classic sample pretreatment method that separates and enriches target components through the partitioning effect between two immiscible liquids. However, this method has disadvantages such as cumbersome operation, high solvent consumption, long processing time, and easy environmental pollution. In addition, liquid-liquid extraction requires high skills of operators and is prone to human errors, affecting the accuracy and repeatability of analysis results.

[0004] 2. Offline solid phase extraction (SPE) technology Compared with liquid-liquid extraction, offline SPE technology has the advantages of simple operation, low solvent consumption, and short processing time. SPE uses solid chromatographic fillers to selectively adsorb and enrich target components, effectively removing impurities from the sample. However, offline SPE technology is time-consuming, requires high skills from operators, and introduces large errors, which increases the cost of analysis, the uncertainty of results, and the difficulty of finding causes.

[0005] 3. Single 2D chromatography system The single two-dimensional chromatography system achieves secondary separation and purification of samples by connecting two independent chromatography systems in series. This method improves the accuracy and sensitivity of the analysis to a certain extent. The analysis time of the single two-dimensional chromatography system is relatively long and cannot meet the needs of rapid analysis. In addition, the existing two-dimensional chromatography throughput is not high. A single two-dimensional chromatography can be connected to an online solid phase extraction column, followed by an analytical column. However, generally only one sample can be subjected to solid phase extraction, and then the analytical column is used for liquid phase separation, and then the mass spectrometer is used for detection. This is equivalent to the mass spectrometer always detecting and waiting for the trigger signal of the liquid phase. Summary of the invention

[0006] Based on the above problems, the present invention provides a dual two-dimensional online solid phase extraction valve cutting device, aiming to solve the obvious shortcomings and limitations of traditional liquid-liquid extraction, offline solid phase extraction and online single two-dimensional chromatography system in the prior art.

[0007] A dual two-dimensional online solid phase extraction valve switching device comprises a first multi-way valve, a second multi-way valve and a first switching module; the first switching module is used for switching the working state; a first fluid channel and a second fluid channel are formed by means of the first multi-way valve, a first SPE column is arranged on the first fluid channel, and a second SPE column is arranged on the second fluid channel; a third fluid channel and a fourth fluid channel are formed by means of the second multi-way valve, a first chromatographic column is arranged on the third fluid channel, and a second chromatographic column is arranged on the fourth fluid channel; when the working state is switched to the first state: the first fluid channel is connected to the third fluid channel, the first fluid channel forms a sample elution channel so that the first SPE column performs sample elution, and the second fluid channel forms a sample enrichment channel so that the second SPE column performs sample enrichment The third fluid channel forms a sample injection channel, receives the sample from the first fluid channel and enables the first chromatographic column to perform a sample chromatographic separation operation, and the fourth fluid channel forms a sample cleaning channel to perform a sample cleaning operation on the second chromatographic column; when the working state is switched to the second state: the second fluid channel is connected to the fourth fluid channel, the second fluid channel forms a sample elution channel to enable the second SPE column to elute the sample, and the first fluid channel forms a sample enrichment channel to enable the first SPE column to enrich the sample; the fourth fluid channel forms a sample injection channel, receives the sample from the second fluid channel and enables the second chromatographic column to perform a sample chromatographic separation operation, and the third fluid channel forms a sample cleaning channel to perform a sample cleaning operation on the first chromatographic column.

[0008] Furthermore, a first inlet valve group, a first outlet valve group, a second inlet valve group and a second outlet valve group are formed in the first multi-way valve; a first fluid channel is formed between the second inlet valve group and the second outlet valve group; a second fluid channel is formed between the second inlet valve group and the second outlet valve group; the first multi-way valve is a ten-way valve, including a first valve position, a second valve position, a third valve position, a fourth valve position, a fifth valve position, a sixth valve position, a seventh valve position, an eighth valve position, a ninth valve position and a tenth valve position adjacent to each other in sequence, and the first valve position is also adjacent to the tenth valve position; when the working state is in the first state, for the first multi-way valve, the first inlet valve group includes the eighth valve position and the ninth valve position connected to each other, the first outlet valve group includes the fourth valve position and the fifth valve position connected to each other, a first SPE column is arranged on the connecting path between the ninth valve position and the fourth valve position, the eighth valve position serves as the input of the first fluid channel, and the fifth valve position serves as the output of the first fluid channel.

[0009] Furthermore, when the working state is in the first state, for the first multi-way valve, the second inlet valve group includes a connected tenth valve position and a first valve position, the second outlet valve group includes a connected sixth valve position and a seventh valve position, a second SPE column is arranged on the connecting path between the first valve position and the sixth valve position, the tenth valve position serves as the input of the second fluid channel, and the seventh valve position serves as the output of the second fluid channel.

[0010] Further, when the working state is in the second state, for the first multi-way valve, the first inlet valve group includes a ninth valve position and a tenth valve position that are connected, the first outlet valve group includes a fourth valve position and a third valve position that are connected, the tenth valve position serves as the input of the first fluid channel, and the third valve position serves as the output of the first fluid channel.

[0011] Furthermore, when the working state is in the second state, for the first multi-way valve, the second inlet valve group includes a second valve position and a first valve position that are connected, the second outlet valve group includes a sixth valve position and a fifth valve position that are connected, and a second SPE column is arranged on the connecting path between the first valve position and the sixth valve position, the second valve position serves as the input of the second fluid channel, and the fifth valve position serves as the output of the second fluid channel.

[0012] Furthermore, a third inlet valve group, a third outlet valve group, a fourth inlet valve group and a fourth outlet valve group are formed in the second multi-way valve; a third fluid channel is formed between the third inlet valve group and the third outlet valve group; a fourth fluid channel is formed between the fourth inlet valve group and the fourth outlet valve group; the second multi-way valve is a ten-way valve, including a first valve position, a second valve position, a third valve position, a fourth valve position, a fifth valve position, a sixth valve position, a seventh valve position, an eighth valve position, a ninth valve position and a tenth valve position adjacent to each other in sequence, and the first valve position is also adjacent to the tenth valve position; when the working state is in the first state, for the second multi-way valve, the third inlet valve group includes a connected tenth valve position and a ninth valve position, the third outlet valve group includes a connected fourth valve position and a third valve position, a first chromatographic column is arranged on the connecting path between the ninth valve position and the fourth valve position, the tenth valve position is connected to the first fluid channel as the input of the third fluid channel, and the third valve position serves as the output of the third fluid channel.

[0013] Furthermore, when the working state is in the first state, for the second multi-way valve, the fourth inlet valve group includes a first valve position and a second valve position that are connected, the fourth outlet valve group includes a fifth valve position and a sixth valve position that are connected, a second chromatographic column is arranged on the connecting path between the first valve position and the sixth valve position, the second valve position serves as the input of the fourth fluid channel, and the fifth valve position serves as the output of the fourth fluid channel.

[0014] Furthermore, when the working state is in the second state, for the second multi-way valve, the third inlet valve group includes an eighth valve position and a ninth valve position that are connected, the third outlet valve group includes a fourth valve position and a fifth valve position that are connected, a first chromatographic column is arranged on the connecting path between the fourth valve position and the ninth valve position, the eighth valve position serves as the input of the third fluid channel, and the fifth valve position serves as the output of the third fluid channel.

[0015] Furthermore, when the working state is in the second state, for the second multi-way valve, the fourth inlet valve group includes a first valve position and a tenth valve position that are connected, the fourth outlet valve group includes a seventh valve position and a sixth valve position that are connected, a second chromatographic column is arranged on the connecting path between the first valve position and the sixth valve position, the tenth valve position serves as the input of the fourth fluid channel, and the seventh valve position serves as the output of the fourth fluid channel.

[0016] The beneficial technical effect of the present invention is: the present invention proposes a dual-dimensional online solid phase extraction device, which aims to achieve high efficiency, automation and intelligence of sample pretreatment through the design of a dual-dimensional extraction system and the introduction of automated control technology, improve the accuracy and sensitivity of analysis, reduce the difficulty and cost of operation, thereby reducing the risk of human error, significantly reducing the consumption of solvents, reducing the risk of environmental pollution, and achieving rapid completion of sample pretreatment, meeting the needs of rapid analysis, and having more prominent applicability for scenarios of some trace samples (medical peripheral blood, criminal investigation samples, etc.). It can achieve double the injection efficiency, and at the same time, it can be in the liquid phase, through valve switching, saving liquid phase time. The device not only solves the shortcomings of the existing technology, but also provides a more convenient and efficient analysis tool for scientific research and industrial production. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a diagram of the preferred valve position connection relationship of a dual-two-dimensional online solid phase extraction valve cutting device in the first state of the present invention.

[0018] Figure 2 This is a diagram of the preferred valve position connection relationship of a dual-two-dimensional online solid phase extraction valve cutting device in the second state of the present invention. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0021] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, but they are not intended to limit the present invention.

[0022] The invention provides a dual two-dimensional online solid phase extraction valve switching device, comprising a first multi-way valve (A), a second multi-way valve (B) and a first switching module; the first switching module is used for switching working states; a first fluid channel and a second fluid channel are formed by means of the first multi-way valve, a first SPE column (SPE1) is arranged on the first fluid channel, and a second SPE column (SPE2) is arranged on the second fluid channel; a third fluid channel and a fourth fluid channel are formed by means of the second multi-way valve, a first chromatographic column (C1) is arranged on the third fluid channel, and a second chromatographic column (C2) is arranged on the fourth fluid channel; when the working state is switched to the first state: the first fluid channel is connected to the third fluid channel, the first fluid channel forms a sample elution channel so that the first SPE column (SPE1) performs sample elution, and the second fluid channel forms a sample enrichment channel so that the second SPE column (SPE2) performs sample enrichment The method comprises the steps of: using a first chromatographic column (C1) and a second chromatographic column (C2) to perform sample chromatographic separation on the first chromatographic column (C1); forming a sample injection channel to receive samples from the first fluid channel and perform sample chromatographic separation on the first chromatographic column (C1); and forming a sample cleaning channel to perform sample cleaning on the second chromatographic column (C2). When the working state is switched to the second state, the second fluid channel is connected to the fourth fluid channel, the second fluid channel forms a sample elution channel to perform sample elution on the second SPE column (SPE2), and the first fluid channel forms a sample enrichment channel to perform sample enrichment on the first SPE column (SPE1); the fourth fluid channel forms a sample injection channel to receive samples from the second fluid channel and perform sample chromatographic separation on the second chromatographic column (C2), and the third fluid channel forms a sample cleaning channel to perform sample cleaning on the first chromatographic column (C1).

[0023] The device is equipped with the same or different solid phase extraction columns (SPE columns), that is, the first SPE column and the second SPE column can be the same or different, and can be replaced with various models and sizes such as C18, WCX, HLB, etc. according to needs. The solid phase extraction columns listed are for illustration. Other types of SPE columns are not elaborated in detail in the present invention, but are still within the scope of protection of the present invention. The software (i.e., the first switching module) configured for the dual-dimensional online solid phase extraction valve cutting device designed by the present invention can be used alone for control or built into the software used by conventional detection instruments to achieve online control. The matching degree is good. Only the time of sample introduction and the valve cutting time need to be modified to realize the state switching control of the two switching valves A and B, thereby controlling the liquid phase flow path and realizing dual injection, dual solid phase extraction, dual chromatographic columns, dual analysis and other functions. See Figure 1, further, a first inlet valve group, a first outlet valve group, a second inlet valve group and a second outlet valve group are formed in the first multi-way valve (A); a first fluid channel is formed between the second inlet valve group and the second outlet valve group; a second fluid channel is formed between the second inlet valve group and the second outlet valve group; the first multi-way valve (A) is a ten-way valve, including a first valve position (A-1), a second valve position (A-2), a third valve position (A-3), a fourth valve position (A-4), a fifth valve position (A-5), a sixth valve position (A-6), a seventh valve position (A-7), an eighth valve position (A-8), and a ninth valve position (A-9). -9), the tenth valve position (A-10), the first valve position is also adjacent to the tenth valve position; when the working state is in the first state, for the first multi-way valve (A), the first inlet valve group includes the eighth valve position (A-8) and the ninth valve position (A-9) which are connected, the first outlet valve group includes the fourth valve position (A-4) and the fifth valve position (A-5) which are connected, a first SPE column (SPE1) is arranged on the connecting path between the ninth valve position (A-9) and the fourth valve position (A-4), the eighth valve position (A-8) serves as the input of the first fluid channel, and the fifth valve position (A-5) serves as the output of the first fluid channel.

[0024] Furthermore, when the working state is in the first state, for the first multi-way valve (A), the second inlet valve group includes the tenth valve position (A-10) and the first valve position (A-1) connected, the second outlet valve group includes the sixth valve position (A-6) and the seventh valve position (A-7) connected, and a second SPE column (SPE2) is arranged on the connecting path between the first valve position (A-1) and the sixth valve position (A-6), the tenth valve position (A-10) serves as the input of the second fluid channel, and the seventh valve position (A-7) serves as the output of the second fluid channel.

[0025] The multi-channel dual two-dimensional online solid phase extraction valve switching device designed by the present invention mainly includes two switching valves, namely the first multi-way valve (A) and the second multi-way valve (B), a dual SPE column, a dual chromatographic column and its liquid connection pipelines. Among them, the first multi-way valve (A) is a ten-way valve with 10 valve positions. For the convenience of explanation, it is named as valve positions A-1 to A-10 to represent the first to tenth valve positions of the first multi-way valve. The second multi-way valve (B) is a ten-way valve with 10 valve positions. For the convenience of explanation, it is named as valve positions B-1 to B-10 to represent the first to tenth valve positions of the second multi-way valve. Both multi-way valves A and B mainly include a stator and a rotor. The connectivity of adjacent position passages can be controlled by adjusting the positions of the stator and the rotor. The first multi-way valve (A) is a dual solid phase extraction switching valve, with the valve positions A-4 and A-9 connected and equipped with the first SPE cartridge (SPE1), and the valve positions A-1 and A-6 on the first multi-way valve (A) connected and equipped with the second SPE cartridge (SPE2). The second multi-way valve (B) is a dual chromatographic column switching valve, with the valve positions B-4 and B-9 connected and equipped with the first chromatographic column C1, and the valve positions B-1 and B-6 on the second multi-way valve (B) connected and equipped with the second chromatographic column (C2).

[0026] See also Figure 2 Further, when the working state is in the second state, for the first multi-way valve (A), the first inlet valve group includes a ninth valve position (A-9) and a tenth valve position (A-10) that are connected, and the first outlet valve group includes a fourth valve position (A-4) and a third valve position (A-3) that are connected, the tenth valve position (A-10) serves as the input of the first fluid channel, and the third valve position (A-3) serves as the output of the first fluid channel.

[0027] Furthermore, when the working state is in the second state, for the first multi-way valve (A), the second inlet valve group includes a second valve position (A-2) and a first valve position (A-1) that are connected, the second outlet valve group includes a sixth valve position (A-6) and a fifth valve position (A-5) that are connected, and a second SPE column (SPE2) is arranged on the connecting path between the first valve position (A-1) and the sixth valve position (A-6), the second valve position (A-2) serves as the input of the second fluid channel, and the fifth valve position (A-5) serves as the output of the second fluid channel.

[0028] Furthermore, a third inlet valve group, a third outlet valve group, a fourth inlet valve group and a fourth outlet valve group are formed in the second multi-way valve (B); a third fluid channel is formed between the third inlet valve group and the third outlet valve group; a fourth fluid channel is formed between the fourth inlet valve group and the fourth outlet valve group; the second multi-way valve (B) is a ten-way valve, including a first valve position (B-1), a second valve position (B-2), a third valve position (B-3), a fourth valve position (B-4), a fifth valve position (B-5), a sixth valve position (B-6), a seventh valve position (B-7), an eighth valve position (B-8), a ninth valve position (B-9), and a tenth valve position (B-10). -10), the first valve position (B-1) is also adjacent to the tenth valve position (B-10); when the working state is in the first state, for the second multi-way valve (B), the third inlet valve group includes the tenth valve position (B-10) and the ninth valve position (B-9) connected to each other, the third outlet valve group includes the fourth valve position (B-4) and the third valve position (B-3) connected to each other, a first chromatographic column (C1) is arranged on the connecting path between the ninth valve position (B-9) and the fourth valve position (B-4), the tenth valve position (B-10) is connected to the first fluid channel as the input of the third fluid channel, and the third valve position (B-3) is the output of the third fluid channel.

[0029] Furthermore, when the working state is in the first state, for the second multi-way valve (B), the fourth inlet valve group includes a first valve position (B-1) and a second valve position (B-2) that are connected, the fourth outlet valve group includes a fifth valve position (B-5) and a sixth valve position (B-6) that are connected, a second chromatographic column (C2) is arranged on the connecting path between the first valve position (B-1) and the sixth valve position (B-6), the second valve position (B-2) serves as the input of the fourth fluid channel, and the fifth valve position (B-5) serves as the output of the fourth fluid channel.

[0030] Furthermore, when the working state is in the second state, for the second multi-way valve (B), the third inlet valve group includes the eighth valve position (B-8) and the ninth valve position (B-9) that are connected, the third outlet valve group includes the fourth valve position (B-4) and the fifth valve position (B-5) that are connected, and a first chromatographic column (C1) is arranged on the connecting path between the fourth valve position (B-4) and the ninth valve position (B-9), the eighth valve position (B-8) serves as the input of the third fluid channel, and the fifth valve position (B-5) serves as the output of the third fluid channel.

[0031] Furthermore, when the working state is in the second state, for the second multi-way valve (B), the fourth inlet valve group includes the first valve position (B-1) and the tenth valve position (B-10) connected to each other, the fourth outlet valve group includes the seventh valve position (B-7) and the sixth valve position (B-6) connected to each other, a second chromatographic column (C2) is arranged on the connecting path between the first valve position (B-1) and the sixth valve position (B-6), the tenth valve position (B-10) serves as the input of the fourth fluid channel, and the seventh valve position (B-7) serves as the output of the fourth fluid channel.

[0032] In the first state, for example Figure 1 As shown, the eighth valve position (A-8) and the tenth valve position (A-10) in the first multi-way valve (A) are described as the injection ports for the sample, activation solution, eluent, etc. to enter the SPE column. The sample enters the first multi-way valve (A) from the eighth valve position (A-8), passes through the ninth valve position (A-9) to the first SPE column (SPE1), then to the fourth valve position (A-4), and flows out of the first multi-way valve (A) through the fifth valve position (A-5). Then, the sample enters the tenth valve position (B-10) of the second multi-way valve (B), passes through the ninth valve position (B-9) to the first chromatographic column (C1), then to the fourth valve position (B-4), and flows out of the second multi-way valve (B) through the third valve position (B-3). Afterwards, it flows to the waste liquid or detector. The elution operation of the SPE column (to achieve sample elution) and the separation operation of the chromatographic column can be performed.

[0033] Similarly, in the first state, the sample enters the first multi-way valve (A) from the tenth valve position (A-10), passes through the first valve position (A-1) to the second SPE column (SPE2), and then to the sixth valve position (A-6), and flows out of the first multi-way valve (A) through the seventh valve position (A-7). After that, it flows to the waste liquid. SPE activation, sample loading and elution operations can be performed. The switching of the first multi-way valve (A) and the second multi-way valve (B) can be achieved without interfering with each other. SPE2 plays the role of sample enrichment. While the SPE2 sample is enriched, the sample enriched by SPE1 enters the first chromatographic column (C1) through the tenth valve position (B-10) of the second multi-way valve (B) for liquid phase separation.

[0034] In the second state, for example Figure 2 As shown, Figure 2 The second valve position (A-2) and the tenth valve position (A-10) of the first multi-port valve (A) are described as the injection ports for samples, activation solution, eluent, etc. to enter the SPE column. The sample enters the first multi-port valve (A) from the second valve position (A-2), passes through the first valve position (A-1) to the second SPE column (SPE2), then to the sixth valve position (A-6), and flows out of the first multi-port valve (A) through the fifth valve position (A-5). Then, the sample enters the tenth valve position (B-10) of the second multi-port valve (B), passes through the first valve position to the second chromatographic column (C2), then to the sixth valve position (B-6), and flows out of the second multi-port valve (B) through the seventh valve position (B-7). Afterwards, it flows to the waste liquid or detector. SPE elution operation and chromatographic column separation operation can be performed.

[0035] Similarly, in the second state, the sample enters the first multi-way valve (A) from the tenth valve position (A-10), passes through the ninth valve position (A-9) to the first SPE column (SPE1), then to the fourth valve position (A-4), and flows out of the first multi-way valve (A) through the third valve position (A-3). After that, it flows to the waste liquid. SPE activation, sample loading and elution operations can be performed.

[0036] The present invention aims to solve the problems of cumbersome operation, large solvent consumption, long processing time and limited separation effect in the sample pretreatment of the prior art through the design and optimization of a dual two-dimensional online solid phase extraction device, realize the full automation and intelligence of sample treatment, and provide a more convenient, efficient and accurate sample pretreatment tool for scientific research and industrial production. Through the implementation of the present invention, the accuracy and sensitivity of analytical tests can be significantly improved, the difficulty and cost of operation can be reduced, and the further development of analytical testing technology can be promoted.

[0037] The above are only preferred embodiments of the present invention, and are not intended to limit the implementation methods and protection scope of the present invention. Those skilled in the art should be aware that all solutions obtained by equivalent substitutions and obvious changes made using the description and illustrations of the present invention should be included in the protection scope of the present invention.

Claims

1. A dual two-dimensional online solid phase extraction valve cutting device, characterized in that: It comprises a first multi-way valve, a second multi-way valve and a first switching module; the first switching module is used for switching the working state; a first fluid channel and a second fluid channel are formed by means of the first multi-way valve, a first SPE column is arranged on the first fluid channel, and a second SPE column is arranged on the second fluid channel; a third fluid channel and a fourth fluid channel are formed by means of the second multi-way valve, a first chromatographic column is arranged on the third fluid channel, and a second chromatographic column is arranged on the fourth fluid channel; When the working state is switched to the first state: the first fluid channel is connected to the third fluid channel, the first fluid channel forms a sample elution channel to elute the sample from the first SPE column, and the second fluid channel forms a sample enrichment channel to enrich the sample from the second SPE column; the third fluid channel forms a sample injection channel to receive the sample from the first fluid channel and to perform a sample chromatographic separation operation on the first chromatographic column, and the fourth fluid channel forms a sample cleaning channel to clean the sample from the second chromatographic column; when the working state is switched to the second state: the second fluid channel is connected to the fourth fluid channel, the second fluid channel forms a sample elution channel to elute the sample from the second SPE column, and the first fluid channel forms a sample enrichment channel to enrich the sample from the first SPE column; the fourth fluid channel forms a sample injection channel to receive the sample from the second fluid channel and to perform a sample chromatographic separation operation on the second chromatographic column, and the third fluid channel forms a sample cleaning channel to clean the sample from the first chromatographic column.

2. A dual-dimensional online solid phase extraction valve cutting device as claimed in claim 1, characterized in that: A first inlet valve group, a first outlet valve group, a second inlet valve group and a second outlet valve group are formed in the first multi-way valve; the first fluid channel is formed between the second inlet valve group and the second outlet valve group; the second fluid channel is formed between the second inlet valve group and the second outlet valve group; the first multi-way valve is a ten-way valve, including a first valve position, a second valve position, a third valve position, a fourth valve position, a fifth valve position, a sixth valve position, a seventh valve position, an eighth valve position, a ninth valve position and a tenth valve position adjacent to each other in sequence, and the first valve position is also adjacent to the tenth valve position; when the working state is in the first state, for the first multi-way valve, the first inlet valve group includes a connected eighth valve position and a ninth valve position, the first outlet valve group includes a connected fourth valve position and a fifth valve position, the first SPE column is arranged on the connecting path between the ninth valve position and the fourth valve position, the eighth valve position serves as the input of the first fluid channel, and the fifth valve position serves as the output of the first fluid channel.

3. A dual-dimensional online solid phase extraction valve cutting device as claimed in claim 2, characterized in that: When the working state is in the first state, for the first multi-way valve, the second inlet valve group includes a connected tenth valve position and a first valve position, the second outlet valve group includes a connected sixth valve position and a seventh valve position, the second SPE column is arranged on the connecting path between the first valve position and the sixth valve position, the tenth valve position serves as the input of the second fluid channel, and the seventh valve position serves as the output of the second fluid channel.

4. A dual-dimensional online solid phase extraction valve cutting device as claimed in claim 2, characterized in that: When the working state is in the second state, for the first multi-way valve, the first inlet valve group includes a ninth valve position and a tenth valve position that are connected, the first outlet valve group includes a fourth valve position and a third valve position that are connected, the tenth valve position serves as the input of the first fluid channel, and the third valve position serves as the output of the first fluid channel.

5. A dual-dimensional online solid phase extraction valve cutting device as claimed in claim 2, characterized in that: When the working state is in the second state, for the first multi-way valve, the second inlet valve group includes a second valve position and a first valve position that are connected, the second outlet valve group includes a sixth valve position and a fifth valve position that are connected, the second SPE column is arranged on the connecting path between the first valve position and the sixth valve position, the second valve position serves as the input of the second fluid channel, and the fifth valve position serves as the output of the second fluid channel.

6. A dual-dimensional online solid phase extraction valve cutting device as claimed in claim 2, characterized in that: A third inlet valve group, a third outlet valve group, a fourth inlet valve group and a fourth outlet valve group are formed in the second multi-way valve; the third fluid channel is formed between the third inlet valve group and the third outlet valve group; the fourth fluid channel is formed between the fourth inlet valve group and the fourth outlet valve group; the second multi-way valve is a ten-way valve, including a first valve position, a second valve position, a third valve position, a fourth valve position, a fifth valve position, a sixth valve position, a seventh valve position, an eighth valve position, a ninth valve position and a tenth valve position adjacent to each other in sequence, and the first valve position is also adjacent to the tenth valve position; when the working state is in the first state, for the second multi-way valve, the third inlet valve group includes a tenth valve position and a ninth valve position connected, the third outlet valve group includes a fourth valve position and a third valve position connected, the first chromatographic column is arranged on the connecting path between the ninth valve position and the fourth valve position, the tenth valve position is connected to the first fluid channel as the input of the third fluid channel, and the third valve position is used as the output of the third fluid channel.

7. A dual-dimensional online solid phase extraction valve cutting device as claimed in claim 6, characterized in that: When the working state is in the first state, for the second multi-way valve, the fourth inlet valve group includes a first valve position and a second valve position that are connected, the fourth outlet valve group includes a fifth valve position and a sixth valve position that are connected, the second chromatographic column is arranged on the connecting path between the first valve position and the sixth valve position, the second valve position serves as the input of the fourth fluid channel, and the fifth valve position serves as the output of the fourth fluid channel.

8. A dual-dimensional online solid phase extraction valve cutting device as claimed in claim 6, characterized in that: When the working state is in the second state, for the second multi-way valve, the third inlet valve group includes an eighth valve position and a ninth valve position that are connected, the third outlet valve group includes a fourth valve position and a fifth valve position that are connected, the first chromatographic column is arranged on the connecting path between the fourth valve position and the ninth valve position, the eighth valve position serves as the input of the third fluid channel, and the fifth valve position serves as the output of the third fluid channel.

9. A dual-dimensional online solid phase extraction valve cutting device as claimed in claim 6, characterized in that: When the working state is in the second state, for the second multi-way valve, the fourth inlet valve group includes a first valve position and a tenth valve position that are connected, the fourth outlet valve group includes a seventh valve position and a sixth valve position that are connected, the second chromatographic column is arranged on the connecting path between the first valve position and the sixth valve position, the tenth valve position serves as the input of the fourth fluid channel, and the seventh valve position serves as the output of the fourth fluid channel.

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