Hearing impairment experimental device and experimental method

Abstract

The invention relates to the technical field of hearing impairment experiments, in particular to a hearing impairment experiment device and an experiment method.The hearing impairment experiment device comprises a noise assembly, the noise assembly comprises a noise chamber and a loudspeaker, the noise chamber is provided with a noise cavity, and the side wall of the noise chamber is provided with a through hole communicated with the noise cavity; the loudspeaker is located at the top of the noise cavity; and the fixing jig is detachably arranged at the through hole of the noise chamber. The noise chamber with the side wall provided with the through hole is additionally arranged, the experimental animal is fixed to the side wall of the noise chamber through the fixing jig, and the head of the experimental animal extends into the noise cavity of the noise chamber through the through hole. The experimental animal is prevented from doing harm-avoiding activities, besides the head of the experimental animal is located outside the noise chamber, damage to various viscera and nervous systems of the experimental animal can be reduced, and then the reliability of experimental data is ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of hearing loss experiments, and in particular to a hearing loss experimental device and an experimental method. Background Art

[0002] Mouse hearing loss models are important tools for studying the mechanisms of hearing loss and developing treatments. The following are some common modeling methods: drug induction, noise exposure, gene editing, surgical injury, and immune injury.

[0003] Among them, the principle of the noise exposure method is to expose mice to a high-intensity noise environment, causing mechanical damage and metabolic disorders to the inner ear, leading to hair cell damage, auditory nerve dysfunction, etc., and then causing hearing loss. However, during the experiment, because the mice can move freely and hide in corners to avoid harm, especially when multiple mice are modeled at the same time, the mice will huddle together to avoid harm. The harm-avoidance behavior of mice can easily block the ear canal, weakening the sound transmitted into the ear, resulting in inconsistent degrees of hearing damage for each mouse, and even inconsistent hearing damage in the left and right ears of the same mouse, which cannot meet the experimental needs.

[0004] At the same time, the mice are placed in a noise room as a whole, and the high-intensity noise can easily affect the various internal organs and nervous systems of the mice, causing unnecessary interference to the experiment. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a hearing loss experimental device and an experimental method to ensure the reliability of experimental data and reduce the damage to the internal organs and nervous system of mice.

[0006] In order to solve the above technical problems, the technical solution adopted by the present invention is as follows: A technical solution adopted by the present invention is as follows: A hearing loss experimental device, comprising a noise component and a fixing fixture, wherein the noise component comprises a noise chamber and a loudspeaker, wherein the noise chamber has a noise cavity, wherein the side wall of the noise chamber is provided with a through hole communicating with the noise cavity, and the loudspeaker is located at the top of the noise cavity; The fixing fixture is detachably arranged at the through hole of the noise chamber.

[0007] In order to solve the above technical problems, another technical solution adopted by the present invention is: an experimental method, having fresh air and a noise environment, The experimental animal was fixed, and only the head of the experimental animal was placed in the noise environment.

[0008] The beneficial effect of the present invention is that: a noise chamber with a through hole in the side wall is added, and the experimental animal is fixed on the side wall of the noise chamber by a fixing fixture, and the head of the experimental animal is extended into the noise cavity of the noise chamber through the through hole. Not only can the experimental animal be prevented from performing harm-avoiding activities, but also the experimental animal is located outside the noise chamber except for the head, which can reduce the damage to the various internal organs and nervous system of the experimental animal, thereby ensuring the reliability of the experimental data. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 This is a schematic diagram of the explosion structure of a hearing loss experimental device proposed by the present invention; Figure 2 This is a schematic diagram of the assembly structure of a noise component, a fixing fixture and a base of a hearing loss experimental device proposed by the present invention; Figure 3 A schematic diagram of the explosion structure of a fixed fixture of a hearing loss experimental device proposed by the present invention; Figure 4 A schematic diagram of a fixed fixture structure of a hearing loss experimental device proposed by the present invention; Figure 5 A schematic diagram of the noise chamber structure of a hearing loss experimental device proposed by the present invention; Figure 6 for Figure 5 A magnified view of part A of a noise chamber of a hearing loss experimental device; Figure 7 This is a schematic diagram of the cross-sectional structure of a base of a hearing loss experimental device proposed by the present invention; Description of labels: 1. Noise component; 11. Noise chamber; 111. Through hole; 112. Plug slot; 113. Silence hole; 114. Decibel detector; 12. Speaker; 2. Fixing fixture; 21. Box body; 211. Exposure hole; 212. Bump; 22. Gate; 23. Second magnet; 3. a first magnet; 4. base; 41. ventilation channel; 42. ventilation boss; 5. Soundproof cover; 51. Heat dissipation holes; 6. Screws. DETAILED DESCRIPTION

[0010] In order to explain the technical content, achieved objectives and effects of the present invention in detail, the following is an explanation in conjunction with the implementation modes and the accompanying drawings.

[0011] Please refer to Figure 1 and Figure 2As shown, a hearing loss experimental device includes a noise component 1 and a fixing fixture 2. The noise component 1 includes a noise chamber 11 and a speaker 12. The noise chamber 11 has a noise cavity. The side wall of the noise chamber 11 is provided with a through hole 111 connected to the noise cavity. The speaker 12 is located at the top of the noise cavity; the fixing fixture 2 is detachably arranged at the through hole 111 of the noise chamber 11.

[0012] Working principle: A noise chamber 11 with a through hole 111 on the side wall is added, and the experimental animal is fixed on the side wall of the noise chamber 11 by a fixing fixture 2, and the head of the experimental animal is allowed to extend into the noise cavity of the noise chamber 11 through the through hole 111. Not only can the experimental animal be prevented from performing harm-avoiding activities, but also the experimental animal, except for the head, is located outside the noise chamber 11, which can reduce damage to various internal organs and nervous systems of the experimental animal, thereby ensuring the reliability of the experimental data.

[0013] It is worth noting that the noise chamber is cylindrical or truncated cone-shaped, the loudspeaker 12 is located at the center of the top of the noise chamber for sound generation, and a plurality of through holes 111 are evenly arranged along the contour of the side wall of the noise chamber 11; so that when experiments are conducted on multiple experimental animals at the same time, the noise intensity to which each experimental animal is subjected tends to be consistent.

[0014] It is worth noting that in order to enhance the effect of the loudspeaker 12 in the noise chamber 11 and reduce the external influence of the loudspeaker 12 , the loudspeaker 12 may be a directional loudspeaker or an acoustic guide may be provided on the loudspeaker 12 .

[0015] Please refer to Figure 3 As shown, in some embodiments, the fixing fixture 2 includes a box body 21 and a gate 22, the box body 21 has a receiving cavity, one end of the box body 21 is provided with an exposure hole 211 connected to the receiving cavity, and the gate 22 is movably arranged on the box body 21 to expand or reduce the communication area between the exposure hole 211 and the receiving cavity. The experimental animal is placed in the receiving cavity of the box body 21, and its head is extended from the exposure hole 211, and then the head of the experimental animal is fixed by operating the gate 22 to prevent the experimental animal from retracting its head into the receiving cavity of the box body 21. At the same time, since the body of the experimental animal is away from the noise chamber 11 and is in the receiving cavity of the box body 21, the damage to the internal organs and nervous system of the experimental animal caused by noise can be reduced as much as possible.

[0016] It is worth noting that the volume of the accommodating chamber of the box body 21 is sufficient for the experimental animal to move around inside, which can reduce the discomfort of the experimental animal. Of course, the accommodating chamber can also have a groove away from the exposure hole 211 for receiving the excrement of the experimental animal, so as to reduce the possibility that the experimental animal is stimulated to excrete and contaminate the accommodating chamber during the experiment.

[0017] Please refer to Figure 3 As shown, in some embodiments, there is a screw 6, a protrusion 212 is provided on the box body 21, and a threaded hole is passed through the protrusion 212. The screw rod of the screw 6 passes through the threaded hole and can abut against the gate 22. The gate 22 can be released and fixed by rotating the screw 6.

[0018] Please refer to Figure 2 and Figure 5 As shown, in some embodiments, a plugging slot 112 for plugging the fixing fixture 2 is provided on the side wall of the noise chamber 11. The fixing fixture 2 can be quickly fixed on the noise chamber 11 through the plugging slot 112.

[0019] Please refer to Figures 4 to 6 As shown, in some embodiments, the side wall of the plug slot 112 is provided with a first magnet 3, and the fixing fixture 2 is provided with a second magnet 23 that is magnetically attracted to the first magnet 3. Through the magnetic attraction of the first magnet 3 and the second magnet 23, it is not only convenient for the operator to install the fixing fixture 2 on the noise chamber 11, but also can improve the installation reliability of the fixing fixture 2 on the noise chamber 11.

[0020] The first magnet 3 and the second magnet can be magnets or electromagnets.

[0021] It is worth noting that there is a pit on the side wall of the plug slot 112, the first magnet 3 is located in the pit, and the second magnet 23 on the fixing fixture 2 can extend into the pit and magnetically attract the first magnet 3. This can further improve the installation reliability of the fixing fixture 2 on the noise chamber 11.

[0022] In some embodiments, the noise chamber 11 also has a silencer chamber connected to the noise chamber, the silencer chamber is located below the noise chamber, a silencer hole 113 connected to the silencer chamber is provided on the side wall of the noise chamber 11, and silencer cotton is provided in the silencer chamber (not shown in the figure). Since the speaker 12 emits sound from the top of the noise chamber 11 downward, a silencer chamber with silencer cotton is provided below the noise chamber to reduce the transmission of noise from the noise chamber 11 to the outside, and at the same time, the noise after being silenced by the silencer cotton is released into a larger space environment through the silencer hole 113. Due to the sudden change in the spatial area, the medium and low frequency noises are reflected and interfered, thereby reducing the sound energy of the medium and low frequency noises.

[0023] Please refer to Figure 1 , Figure 2 and Figure 5 As shown, in some embodiments, the noise chamber 11 is provided with a decibel detector 114. The decibel detector 114 is used to detect the noise intensity in the noise chamber to facilitate experimental data statistics.

[0024] Please refer to Figure 7As shown, in some embodiments, the hearing loss experimental device further includes a base 4, the noise component 1 is disposed on the base 4, and a ventilation channel 41 connected to the noise cavity is disposed on the base 4. The ventilation channel 41 ensures that the air flow in the noise cavity has reduced the heat generated by the operation of the components in the base 4.

[0025] It is worth noting that a ventilation boss 42 is provided on the base 4, and a plurality of ventilation holes connected to the ventilation channel 41 are evenly arranged along the contour of the side wall of the ventilation boss 42 to ensure uniform ventilation in the uniform noise chamber 11, and silencer cotton is arranged on the side wall of the ventilation boss 42 to reduce the intensity of noise transmitted from the ventilation channel 41 to the outside. Of course, in order to improve the ventilation effect, a fan can be set at the air inlet of the ventilation channel 41.

[0026] Please refer to Figure 1 As shown, in some embodiments, the hearing loss experimental device further includes a soundproof cover 5, wherein the noise component 1 is located in the inner cavity of the soundproof cover 5, and a sound-absorbing cotton (not shown in the figure) is provided on the inner wall of the soundproof cover 5. The soundproof cover 5 is used to further reduce the transmission of noise from the noise chamber 11 to the outside.

[0027] Please refer to Figure 1 As shown, in some embodiments, a plurality of heat dissipation holes 51 are provided on the top of the soundproof cover 5. The heat dissipation holes 51 can be used to dissipate the heat generated by the noise component 1 to the outside, especially the heat generated by the operation of the speaker 12.

[0028] An experimental method comprises a noise environment, fixing an experimental animal, and placing only the head of the experimental animal in the noise environment.

[0029] Furthermore, there is an isolation space, and the experimental animal is located in the isolation space.

[0030] From the above description, it can be seen that the isolated space can reduce the damage to the internal organs and nervous system of experimental animals caused by the noise released in the noisy environment.

[0031] Furthermore, the isolation space can be used for physical activities of experimental animals.

[0032] In the mouse hearing loss experiment, if the exposure is high-intensity and short-term, the mice need to be in a noise environment of 115dB to 125dB; if the exposure is moderate-intensity, the mice need to be in an environment of 90dB to 115dB.

[0033] The structure of the hearing loss experimental device of the present invention is subjected to a noise test. Specifically, the noise chamber 11, the fixing fixture 2, the base 4, the soundproof cover 5 and other non-electronic components are made of PLA materials (can be prepared by 3D printing), a full-range speaker and a 200W power amplifier are used as the sound source, and a 3cm thick sound-absorbing cotton is pasted on the inner wall of the soundproof cover 5. The sound source is set to release 125dB noise, and the decibel value at the exposure hole 211 of the box body 21 is measured to be about 125dB, and the decibel value in the accommodating cavity of the box body 21 is about 110dB. At 20cm outside the hearing loss experimental device, when the soundproof cover 5 is not set, the decibel value reaches about 102dB, and when the soundproof cover 5 is set, the decibel value reaches about 80dB.

[0034] The sound source was set to release 115dB noise, and the decibel value at the exposure hole 211 of the box body 21 was measured to be about 108dB, and the decibel value in the accommodating cavity of the box body 21 was about 91dB. 20 cm outside the hearing loss experimental device, when the soundproof cover 5 was not set, the decibel value reached about 85dB, and when the soundproof cover 5 was set, the decibel value reached about 70dB.

[0035] From the test results, it can be seen that the hearing loss experimental device structure of the present invention meets the noise requirements of the mouse hearing loss experiment and will not cause a significant impact on the external environment.

[0036] Furthermore, a fan with a rated voltage of 12V and a rated current of 0.5A was set at the air inlet of the ventilation channel 41, and a temperature test was performed with a sound source releasing 125dB noise at a room temperature of about 25°C. After the sound source worked continuously for two hours, the temperature at the exposure hole 211 of the box body 21 was about 26.8°C, and the temperature in the accommodating cavity of the box body 21 was about 27.1°C. From the test results, it can be seen that the hearing loss experimental device structure of the present invention has good heat dissipation, which can reduce unnecessary interference of temperature to the experiment.

[0037] The above descriptions are merely embodiments of the present invention and are not intended to limit the patent scope of the present invention. Any equivalent transformations made using the contents of the present invention's specification and drawings, or directly or indirectly applied in related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A hearing loss experimental device, characterized in that: It comprises a noise component and a fixing fixture, wherein the noise component comprises a noise chamber and a speaker, wherein the noise chamber has a noise cavity, a side wall of the noise chamber is provided with a through hole communicating with the noise cavity, and the speaker is located at the top of the noise cavity; The fixing fixture is detachably arranged at the through hole of the noise chamber.

2. The hearing loss experimental device according to claim 1, characterized in that: The fixing fixture comprises a box body and a gate, wherein the box body has a receiving cavity, one end of the box body is provided with an exposure hole connected with the receiving cavity, and the gate is movably arranged on the box body to expand or reduce the communication area between the exposure hole and the receiving cavity.

3. The hearing loss experimental device according to claim 1, characterized in that: The side wall of the noise chamber is provided with an inserting groove for inserting a fixing fixture.

4. The hearing loss experimental device according to claim 3, characterized in that: A first magnet is disposed on the side wall of the plug-in slot, and a second magnet that is magnetically attracted to the first magnet is disposed on the fixing fixture.

5. The hearing loss experimental device according to claim 1, characterized in that: The noise chamber also has a silencer chamber connected to the noise cavity, the silencer chamber is located below the noise cavity, a silencer hole connected to the silencer chamber is arranged on the side wall of the noise chamber, and silencer cotton is arranged in the silencer chamber.

6. The hearing loss experimental device according to claim 1, characterized in that: A decibel detector is provided on the noise chamber.

7. The hearing loss experimental device according to claim 1, characterized in that: It also includes a base, the noise component is arranged on the base, and the base is provided with a ventilation channel connected with the noise cavity.

8. The hearing loss experimental device according to claim 1, characterized in that: It also includes a soundproof cover, wherein the noise component is located in the inner cavity of the soundproof cover, and sound-absorbing cotton is arranged on the inner wall of the soundproof cover.

9. An experimental method based on the hearing loss experimental device according to any one of claims 1 to 8, characterized in that: In a noisy environment, The experimental animal was fixed, and only the head of the experimental animal was placed in the noise environment.

10. The experimental method according to claim 9, characterized in that: An isolation space is provided, and the experimental animal is located in the isolation space.

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