Traditional Chinese medicine formula for improving anorexia symptom after tumor chemoradiotherapy

Abstract

The invention discloses a traditional Chinese medicine formula for improving anorexia symptoms after tumor radiotherapy and chemotherapy, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition is prepared from the following raw materials by weight: 8-16 g of fried rhizoma atractylodis, 8-16 g of ginger processed officinal magnolia bark, 8-16 g of dried orange peel, 8-16 g of round cardamom fruit, 8-16 g of villous amomum fruit, 8-16 g of anise, 8-16 g of root of Chinese fargesia, 8-16 g of Chinese yam, 8-16 g of dark malt, 8-16 g of scorched hawthorn fruit, and 8-16 g of scorched medicated leaven. , 8-16 g of green bamboo shavings, 8-16 g of inula flower and 8-16 g of root of kudzu vine. According to clinical tests, 150 patients with anorexia after tumor radiotherapy and chemotherapy are selected, the traditional Chinese medicine liquid is adopted for treatment, the total effective rate reaches 83.33% after treatment for one week and is increased to 93.33% after treatment for two weeks, and the symptom total integral, the appetite and food intake integral, nausea, vomiting and other accompanying symptom integral are all remarkably reduced. The traditional Chinese medicine formula disclosed by the invention has a remarkable effect on improving anorexia symptoms after tumor chemoradiotherapy, can effectively promote the appetite of a patient and relieve accompanying symptoms, and has an important clinical application value.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine formula for improving anorexia symptoms after tumor radiotherapy and chemotherapy. Background Art

[0002] Tumor radiotherapy and chemotherapy are currently important means of treating malignant tumors. However, while fighting cancer, a series of side effects caused by radiotherapy and chemotherapy have brought a heavy burden to patients, among which anorexia is particularly prominent.

[0003] In the clinical treatment of tumors, radiotherapy and chemotherapy are widely used, but it is very common for patients to experience anorexia after radiotherapy and chemotherapy. According to a large number of clinical research statistics, more than half of radiotherapy and chemotherapy patients will suffer from anorexia to varying degrees. Anorexia causes patients to have severe nutritional deficiencies, rapid weight loss, and physical weakness, which in turn leads to a sharp decrease in the body's immunity. This not only seriously affects the patient's quality of life, causing them to suffer both physical and psychological torture during treatment, but also interferes with the normal progress of subsequent radiotherapy and chemotherapy, reduces the treatment effect, and may even delay the entire treatment process, which has an extremely adverse effect on the patient's prognosis.

[0004] At present, modern medicine mainly uses prokinetic drugs, hormone drugs, etc. to treat anorexia symptoms after tumor radiotherapy and chemotherapy. However, these drugs have many disadvantages. Although prokinetic drugs can promote gastrointestinal motility to a certain extent, they have limited effect on improving patients' appetite, and some patients will experience adverse reactions such as abdominal pain and diarrhea during use. Although hormone drugs can increase appetite, long-term use can cause a series of serious side effects, such as endocrine disorders, osteoporosis, etc., increase patients' new health risks, and are greatly restricted in dosage and course of treatment, and cannot meet the needs of clinical treatment.

[0005] Traditional Chinese medicine has a long history and unique theoretical system in treating various diseases. It has the advantages of overall conditioning and few side effects. In recent years, more and more studies have begun to focus on the potential of traditional Chinese medicine in improving anorexia symptoms after tumor radiotherapy and chemotherapy. Traditional Chinese medicine can not only regulate gastrointestinal function and promote digestion and absorption through multi-target and multi-pathway mechanisms, but also regulate the body's immune function and internal environment, fundamentally improving the patient's physical condition. However, most of the existing traditional Chinese medicine formulas lack rigorous clinical trial verification, and their efficacy and safety have not been fully confirmed, which is subject to certain restrictions in actual clinical applications. Summary of the invention

[0006] The present invention provides a traditional Chinese medicine formula for improving anorexia symptoms after tumor radiotherapy and chemotherapy, which is used to improve anorexia symptoms after tumor radiotherapy and chemotherapy. The specific contents of the present invention are as follows.

[0007] The present invention discloses a Chinese medicine formula for improving anorexia symptoms after tumor radiotherapy and chemotherapy. The Chinese medicine composition is prepared from the following raw materials in weight ratio:

[0008] Stir-fried Atractylodes macrocephala 8-16g, Magnolia officinalis bark 8-16g, Tangerine peel 8-16g, White cardamom 8-16g, Amomum villosum 8-16g, Fennel 8-16g, Gastrodia elata root 8-16g, Dioscorea opposita 8-16g, Roasted malt 8-16g, Roasted hawthorn 8-16g, Roasted Shenqu 8-16g, Green bamboo shavings 8-16g, Inula flower 8-16g, Pueraria root 8-16g.

[0009] Preferably, the Chinese medicine composition is prepared from the following raw materials in the following weight ratios:

[0010] Stir-fried Atractylodes macrocephala 10-14g, Magnolia officinalis bark 10-14g, Tangerine peel 10-14g, White Cardamom 10-14g, Amomum villosum 10-14g, Fennel 10-14g, Scutellaria baicalensis root 10-14g, Chinese yam 10-14g, roasted malt 10-14g, roasted hawthorn 10-14g, roasted Shenqu 10-14g, Green Bamboo Rhizome 10-14g, Inula flower 10-14g, Pueraria root 10-14g.

[0011] More preferably, the Chinese medicine composition is prepared from the following raw materials in weight ratio:

[0012] Stir-fried Atractylodes macrocephala 12g, Magnolia officinalis bark 12g, Tangerine peel 12g, White cardamom 12g, Amomum villosum 12g, Fennel 12g, Shigua root 12g, Chinese yam 12g, roasted malt 12g, roasted hawthorn 12g, roasted Shenqu 12g, Green bamboo shavings 12g, Inula flower 12g, Pueraria root 12g.

[0013] The present invention also provides a method for preparing a Chinese medicinal piece for improving anorexia symptoms after tumor radiotherapy and chemotherapy, comprising the following steps:

[0014] The stir-fried Atractylodes macrocephala, Magnolia officinalis bark, dried tangerine peel, white cardamom, Amomum villosum, fennel, root of dwarf melon, yam, roasted malt, roasted hawthorn, roasted Shenqu, Rhizoma Anemarrhenae, Inula flower and Pueraria root in the above weight proportion are mixed, crushed, passed through an 80-100 mesh sieve, mixed evenly, and tableted to obtain Chinese herbal medicine slices for improving anorexia symptoms after tumor radiotherapy and chemotherapy.

[0015] The present invention also provides two methods of taking the above-mentioned Chinese herbal medicine slices for improving anorexia symptoms after tumor radiotherapy and chemotherapy:

[0016] Method 1: Take a piece of the Chinese herbal medicine slice, soak it in 800 mL of drinking water for 60 minutes, put the slice and water into a casserole, boil it with high heat first, then simmer it with low heat for 20 minutes, boil it with high heat again, then simmer it with low heat for 20 minutes, take a total of 400-450 mL of the liquid medicine, take it in divided doses, 200 mL each time, twice a day, and take it for 1 week.

[0017] Method 2: Take a piece of the Chinese herbal medicine, soak it in 800 mL of drinking water for 60 minutes, put the piece and water into a casserole, boil it with high heat first, then simmer it with low heat for 20 minutes, boil it with high heat again, then simmer it with low heat for 20 minutes, take a total of 400-450 mL of the liquid medicine, take it in divided doses, 150 mL each time, 3 times a day, and take it for 1 week.

[0018] The present invention has the following beneficial effects:

[0019] 1. The fried Atractylodes macrocephala in the formula can dry out dampness and strengthen the spleen, while the ginger and Magnolia bark can promote qi and eliminate accumulation, dry out dampness and relieve fullness. The two are the main ingredients, which can effectively improve the spleen and stomach transportation and transformation functions, eliminate spleen and stomach dampness stagnation, restore the spleen and stomach's ascending and descending functions, and relieve the anorexia symptoms caused by spleen and stomach weakness and inability to transport and transform after radiotherapy and chemotherapy.

[0020] Tangerine peel regulates qi and strengthens the spleen, dries dampness and resolves phlegm, white cardamom eliminates dampness and promotes qi circulation, warms the middle and stops vomiting, Amomum villosum eliminates dampness and promotes qi circulation, warms the spleen and stops diarrhea, and fennel dispels cold and relieves pain, regulates qi and harmonizes the stomach. These herbs synergize with the main herb to enhance the effects of promoting qi and strengthening the spleen, eliminating dampness and harmonizing the stomach, and are therefore the assistant herb.

[0021] Yam nourishes the spleen and stomach, promotes fluid production and benefits the lungs, nourishes the kidneys and astringes the essence. It can strengthen the spleen and replenish qi, and further enhance the function of the spleen and stomach; roasted malt, roasted hawthorn, and roasted Shenqu, namely the "Three Burnt Immortals", have the function of digesting food and eliminating accumulation, can promote food digestion, and relieve loss of appetite; Green Bamboo Rhizome clears away heat and resolves phlegm, relieves restlessness and stops vomiting, and Inula Flower descends qi and resolves phlegm, and descends adverse qi and stops vomiting. Both can alleviate symptoms such as gastric adverse qi, nausea and vomiting caused by radiotherapy and chemotherapy drugs, and help improve anorexia; Pueraria root relieves muscles and reduces fever, promotes fluid production and quenches thirst, raises yang and stops diarrhea. It can encourage the spleen and stomach's clear yang qi to rise, and promote the spleen and stomach's transportation and transformation. The above medicines are adjuvants.

[0022] The combination of these medicines can strengthen the spleen and stomach, eliminate dampness and accumulation, and relieve adverse reactions and stop vomiting, thereby effectively improving the symptoms of anorexia after tumor radiotherapy and chemotherapy and increasing the patient's appetite.

[0023] 2. Animal experimental data showed that the food intake and food intake increment of the model group rats were significantly lower than those of the normal group, while after the administration of the Chinese medicine composition, the food intake of the medium-dose group and the food intake increment of each dose group were significantly higher than those of the model group. This shows that the Chinese medicine composition of the present invention can effectively improve the appetite of anorexic rats, increase their food intake, and improve the body's nutritional intake. In clinical trials, the total effective rate reached 83.33% after 1 week of treatment, and rose to 93.33% after 2 weeks, and the appetite and food intake scores decreased significantly after treatment. This means that after taking the Chinese medicine of the present invention, the appetite of most patients is significantly improved, the food intake gradually increases, and the anorexia symptoms after tumor radiotherapy and chemotherapy are effectively alleviated, which helps to improve the nutritional status and quality of life of patients.

[0024] 3. The results of animal experiments showed that the gastric residual rate of the model group was significantly higher than that of the normal group, and the intestinal propulsion rate was significantly lower than that of the normal group, indicating that the modeling led to gastrointestinal dysfunction. The gastric residual rate of each dose group of the Chinese medicine composition was lower than that of the model group, and the intestinal propulsion rate of the medium and high dose groups was significantly higher than that of the model group. This fully proves that the Chinese medicine composition of the present invention can effectively improve gastric motility, increase gastric emptying, enhance intestinal motility, promote intestinal propulsion, and then promote food digestion, which is helpful to restore the damaged gastrointestinal function of patients undergoing radiotherapy and chemotherapy.

[0025] 4. Clinical trial data show that after receiving the treatment of the Chinese medicine of the present invention, the scores of nausea and vomiting, abdominal distension, constipation or diarrhea, fatigue, mental state and other radiotherapy and chemotherapy-related concomitant symptoms of patients have significantly decreased. This shows that the Chinese medicine of the present invention can not only improve the symptoms of anorexia, but also has a good alleviating effect on other discomfort symptoms after radiotherapy and chemotherapy, which can comprehensively improve the physical condition of patients, relieve the pain of patients, improve the quality of life of patients, enable patients to better restore their physical functions after radiotherapy and chemotherapy, and provide better physical conditions for subsequent treatment.

[0026] 5. In animal experiments, the high-dose group of the Chinese medicine composition has significant effects in promoting weight gain, reducing gastric residual rate, and increasing intestinal propulsion rate, reflecting a significant dose-effect relationship. In clinical trials, as the treatment time increases from 1 week to 2 weeks, the total effective rate increases, and the symptom score further decreases, indicating that the efficacy of the Chinese medicine of the present invention is sustainable, and as the medication time increases, the effect is better, which can provide patients with a longer-term and stable treatment effect, and is of great significance for improving anorexia symptoms after tumor radiotherapy and chemotherapy. DETAILED DESCRIPTION

[0027] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] Example 1

[0029] According to the weight ratio of stir-fried Atractylodes lancea 8g, ginger magnolia bark 8g, dried orange peel 8g, white cardamom 8g, Amomum villosum 8g, fennel 8g, dung melon root 8g, yam 8g, scorched malt 8g, scorched hawthorn 8g, scorched Shenqu 8g, green bamboo 8g, inula 8g, and pueraria 8g, the above medicinal materials are mixed, crushed, passed through an 80-mesh sieve, mixed evenly, and tableted to make Chinese medicine slices. Take it according to the first method of taking, select 20 patients with anorexia symptoms after tumor radiotherapy and chemotherapy, aged between 35-65 years old, with an average age of 50 years old, and start taking the Chinese medicine slices of the present invention after the end of radiotherapy and chemotherapy, and observe the improvement of appetite after the patient takes it for 1 week. The results showed that 12 patients had significantly improved appetite and increased food intake; 5 patients had improved appetite and slightly increased food intake; 3 patients had no obvious improvement in symptoms.

[0030] Example 2

[0031] According to the weight ratio of stir-fried Atractylodes macrocephala 16g, ginger magnolia bark 16g, dried orange peel 16g, white cardamom 16g, Amomum villosum 16g, fennel 16g, dung melon root 16g, yam 16g, scorched malt 16g, scorched hawthorn 16g, scorched Shenqu 16g, green bamboo 16g, inula flower 16g, kudzu root 16g, the above medicinal materials are mixed, crushed, passed through a 100-mesh sieve, mixed evenly, and tableted to make Chinese medicine slices. Take it according to the second method of taking, select 20 patients with anorexia symptoms after tumor radiotherapy and chemotherapy, aged between 40-70 years old, with an average age of 55 years old, start taking the Chinese medicine slices of the present invention after the end of radiotherapy and chemotherapy, and observe the improvement of appetite after the patient takes it for 1 week. The results showed that 13 patients had significantly improved appetite and increased food intake; 4 patients had improved appetite and slightly increased food intake; 3 patients had no obvious improvement in symptoms.

[0032] Example 3

[0033] According to the weight ratio of stir-fried Atractylodes macrocephala 12g, ginger magnolia bark 12g, dried orange peel 12g, white cardamom 12g, Amomum villosum 12g, fennel 12g, dung melon root 12g, yam 12g, scorched malt 12g, scorched hawthorn 12g, scorched Shenqu 12g, green bamboo shavings 12g, inula flower 12g, and pueraria root 12g, the above medicinal materials are mixed, crushed, passed through a 90-mesh sieve, mixed evenly, and tableted to make Chinese medicine slices. According to the taking method one and the taking method two, they are grouped and taken respectively. Each group has 20 patients with anorexia symptoms after tumor radiotherapy and chemotherapy, aged between 30-60 years old, with an average age of 45 years old. After the end of radiotherapy and chemotherapy, they start to take the Chinese medicine slices of the present invention, and observe the improvement of appetite after the patients take it for 1 week. The results show that in the taking method group, 15 patients have significantly improved appetite and increased food intake; 4 patients have improved appetite and slightly increased food intake; 1 patient has no obvious improvement in symptoms. In group 2, 16 patients had significantly improved appetite and increased food intake; 3 patients had improved appetite and slightly increased food intake; and 1 patient had no significant improvement in symptoms.

[0034] Performance Testing

[0035] (I) Animal experiments

[0036] Experimental animals and modeling: 50 healthy SD rats were selected, 1 week after weaning, weighing 60±10g, half male and half female, SPF grade. Except for 10 rats in the normal group, the remaining rats were injected intraperitoneally with 80mg / kg of cyclophosphamide to establish anorexia rat model after tumor radiotherapy and chemotherapy, and the injection was continued for 3 days. During the modeling period, the normal group was given ordinary feed and drinking water, and the modeling group was given the same feed but restricted diet, with a daily feeding amount of 60% of the normal group. The modeling was successful when the food intake of the modeling group rats decreased by 30%-60% compared with the normal group and the weight gain was slow or decreased.

[0037] Grouping and administration: After modeling, the modeling rats were randomly divided into a model group, a low-, medium-, and high-dose group of the Chinese medicine composition, and a positive control group, with 8 rats in each group. The normal group and the model group were gavaged with 1.5 ml / 100 g of normal saline, the low-, medium-, and high-dose groups of the Chinese medicine composition were gavaged with 7.5 g / kg, 15 g / kg (clinical equivalent dose), and 30 g / kg of the Chinese medicine composition, respectively, and the positive control group was gavaged with 10 mg / kg of metoclopramide, once a day.

[0038] Index detection

[0039] Body weight and food intake: Weigh and record the weight of rat feed on the 1st, 7th, 14th, 21st and 28th days, calculate the rat's 24-hour food intake based on the feed supplementation amount of the previous day and the residual amount of the day, and weigh and record the rat's body weight to monitor body weight changes.

[0040] Gastric emptying: After the last oral gavage, the rats were fasted for 24 hours, during which time the rats were free to drink water. After fasting for 24 hours, the rats were gavaged with nutritious semisolid paste (2 ml each). 60 minutes after oral gavage, the rats were anesthetized with 3% pentobarbital solution 30 mg / kg, 0.1 ml / 100 g intraperitoneally, and blood was collected from the abdominal aorta. Then the gastric cardia and pylorus were ligated, the stomach was quickly removed, wiped dry with filter paper, and weighed. An opening was made above the stomach, and after flushing the stomach residue with saline, the stomach was wiped dry with filter paper, and its net weight was weighed and recorded. Calculation of gastric residual rate = (total weight of stomach - net weight) / oral gavage amount × 100%.

[0041] Intestinal propulsion: After removing the gastric body, quickly separate the mesentery, find the small intestine and place the entire section of the small intestine on white paper without applying traction. Measure the distance from the pyloric sphincter to the point where the charcoal paste reaches as the activated charcoal propulsion distance L2, and measure the distance from the pyloric sphincter to the end of the ileum as the total length of the small intestine L1. Calculate the small intestine propulsion rate = L2 / L1×100%.

[0042] 2. Clinical trials

[0043] Case selection: 150 patients with anorexia after chemoradiotherapy who visited the oncology department of a tertiary hospital from January 2024 to December 2024 were selected. The patients were aged between 30 and 70 years old, with an average age of 50 years old. Inclusion criteria: diagnosed with malignant tumors and receiving chemoradiotherapy; anorexia after chemoradiotherapy, manifested as loss of appetite and reduced food intake; signed informed consent. Exclusion criteria: patients with severe organ dysfunction such as heart, liver, and kidney; patients with mental illness; patients who are allergic to this Chinese medicine composition.

[0044] Treatment drugs and dosage: Use the Chinese medicine liquid prepared as above, adjust the dosage according to the patient's age and weight, generally 10-20 ml each time, 3 times a day, orally half an hour after a meal, and take it continuously for 2 weeks as a course of treatment.

[0045] Observation of therapeutic effect: observe the total effective rate after 1 and 2 weeks of treatment, record the total symptom score before and after treatment, the score of each main symptom (appetite, food intake), the score of each secondary symptom (nausea and vomiting, abdominal distension, constipation or diarrhea, fatigue, mental state) and the improvement and disappearance of secondary symptoms.

[0046] Efficacy judgment criteria: cure means that appetite returns to normal, food intake returns to the level before radiotherapy and chemotherapy, and other symptoms disappear; marked effect means that appetite is significantly improved, food intake increases by more than 50% before radiotherapy and chemotherapy, and other symptoms are significantly alleviated; effectiveness means that appetite is improved, food intake increases by 20%-50% before radiotherapy and chemotherapy, and other symptoms are alleviated; ineffective means that symptoms are not improved or are aggravated.

[0047] Test results

[0048] Table 1 shows the results of animal experiments.

[0049]

[0050]

[0051]

[0052] Table 2 is the clinical trial test results table

[0053]

[0054]

[0055]

[0056]

[0057]

[0058] Data analysis

[0059] Animal experiment data:

[0060] Body weight and food intake: 28 days after modeling, the weight gain of the model group (190.00±50.00g) was lower than that of the normal group (220.00±80.00g), indicating that the modeling successfully inhibited the weight gain of rats. After 2 weeks of administration, the weight gain of the high-dose Chinese medicine composition group (110.00±30.00g) was significantly higher than that of the model group (65.00±40.00g), indicating that the high-dose Chinese medicine composition can effectively promote the weight gain of anorexic rats. The food intake of the model group (20.00±6.00g) was lower than that of the normal group (25.00±8.00g), and the food intake increment (-0.50±3.00g) was negative, indicating that modeling caused a decrease in appetite and food intake in rats. The food intake (28.00±8.00g) and food intake increment (13.00±4.00g) of the medium-dose group of the Chinese medicine composition were significantly higher than those of the model group, indicating that the medium-dose Chinese medicine can significantly improve the appetite and food intake of anorexic rats, and the effect is better than that of the low-dose group and the positive control group (metoclopramide group).

[0061] Gastric emptying and intestinal propulsion: The gastric residual rate in the model group (40.00±8.00%) was significantly higher than that in the normal group (20.00±5.00%), indicating that modeling delayed gastric emptying. The gastric residual rate in each dose group of the Chinese medicine composition was lower than that in the model group, among which the high dose group (22.00±5.00%) was the most significant, indicating that the Chinese medicine composition can effectively promote gastric emptying, and the high dose has the best effect, which is better than the positive control group (28.00±7.00%). The intestinal propulsion rate in the model group (40.00±7.00%) was significantly lower than that in the normal group (60.00±8.00%), indicating that intestinal peristalsis was weakened. The intestinal propulsion rates of the medium and high dose groups of the Chinese medicine composition were 50.00±9.00% and 55.00±8.00%, respectively, which were significantly higher than those of the model group, indicating that the medium and high doses of the Chinese medicine composition can effectively enhance intestinal peristalsis and promote intestinal propulsion, and the high dose has a better effect. The intestinal propulsion rate of the positive control group was 48.00±8.00%, and the high dose group of the Chinese medicine composition was slightly better than the positive control group.

[0062] Clinical trial data

[0063] Efficacy statistics: After 1 week of treatment, the total effective rate of 150 patients was 83.33%, 25 cases were ineffective (16.67%), 100 cases were effective (66.67%), 20 cases were significantly effective (13.33%), and 5 cases were cured (3.33%). After 2 weeks of treatment, the total effective rate increased to 93.33%, the ineffective rate decreased to 10 cases (6.67%), the significantly effective rate increased to 80 cases (53.33%), and 30 cases were cured (20.00%). This shows that the Chinese medicine liquid has a good effect on the treatment of anorexia symptoms after tumor radiotherapy and chemotherapy, and as the treatment time is prolonged, the effect is more significant, and more patients can get significant improvement in symptoms.

[0064] Symptom score: The total symptom score was 18.00±4.00 before treatment, which dropped to 10.00±3.00 after 1 week of treatment, and further dropped to 5.00±2.00 after 2 weeks, indicating that the Chinese medicine liquid can continuously alleviate the overall symptoms of patients. The appetite score was 6.00 (3.00, 6.00) before treatment, which dropped to 3.00 (0.00, 3.00) after 1 week of treatment, and became 0.00 (0.00, 0.00) after 2 weeks; the change of food intake score was similar, reflecting that the appetite and food intake of patients were significantly improved. The secondary symptom scores of nausea and vomiting, abdominal distension, constipation or diarrhea, fatigue, and mental state also decreased significantly after treatment, indicating that the Chinese medicine liquid not only improves anorexia symptoms, but also has a good effect on relieving the related accompanying symptoms after radiotherapy and chemotherapy, and can comprehensively improve the physical condition of patients.

[0065] Although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that all equivalent changes and improvements made within the scope of the present invention should still fall within the scope of the patent coverage of the present invention.

Claims

1. A Chinese medicine formula for improving anorexia symptoms after tumor radiotherapy and chemotherapy, characterized in that: The Chinese medicine composition is prepared from the following raw materials in weight ratio: Stir-fried Atractylodes macrocephala 8-16g, Magnolia officinalis bark 8-16g, Tangerine peel 8-16g, White cardamom 8-16g, Amomum villosum 8-16g, Fennel 8-16g, Gastrodia elata root 8-16g, Dioscorea opposita 8-16g, Roasted malt 8-16g, Roasted hawthorn 8-16g, Roasted Shenqu 8-16g, Green bamboo shavings 8-16g, Inula flower 8-16g, Pueraria root 8-16g.

2. The Chinese medicine formula for improving anorexia symptoms after tumor radiotherapy and chemotherapy according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following raw materials in weight ratio: Stir-fried Atractylodes macrocephala 10-14g, Magnolia officinalis bark 10-14g, Tangerine peel 10-14g, White Cardamom 10-14g, Amomum villosum 10-14g, Fennel 10-14g, Scutellaria baicalensis root 10-14g, Chinese yam 10-14g, roasted malt 10-14g, roasted hawthorn 10-14g, roasted Shenqu 10-14g, Green Bamboo Rhizome 10-14g, Inula flower 10-14g, Pueraria root 10-14g.

3. The Chinese medicine formula for improving anorexia symptoms after tumor radiotherapy and chemotherapy according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following raw materials in weight ratio: Stir-fried Atractylodes macrocephala 12g, Magnolia officinalis bark 12g, Tangerine peel 12g, White cardamom 12g, Amomum villosum 12g, Fennel 12g, Shigua root 12g, Chinese yam 12g, roasted malt 12g, roasted hawthorn 12g, roasted Shenqu 12g, Green bamboo shavings 12g, Inula flower 12g, Pueraria root 12g.

4. A method for preparing a Chinese medicinal piece for improving anorexia symptoms after tumor radiotherapy and chemotherapy, characterized in that: The following steps are involved: The stir-fried Atractylodes macrocephala, Magnolia officinalis, dried tangerine peel, white cardamom, Amomum villosum, fennel, root of dung melon, yam, roasted malt, roasted hawthorn, roasted Shenqu, Rhizoma Anemarrhenae, Inula flower and Pueraria root in the weight proportion described in any one of claims 1 to 3 are mixed, crushed, passed through an 80-100 mesh sieve, mixed evenly, and tableted to obtain a Chinese medicine slice for improving anorexia symptoms after tumor radiotherapy and chemotherapy.

5. A method of taking the Chinese herbal medicine slices for improving anorexia symptoms after tumor radiotherapy and chemotherapy according to claim 4, characterized in that: The method comprises the following steps: taking a piece of the Chinese medicinal slice, soaking the slice in 800 ml of drinking water for 60 minutes, putting the slice and the water into a casserole, first boiling with high heat, then decocting with low heat for 20 minutes, boiling with high heat again, then decocting with low heat for 20 minutes, taking a total of 400-450 ml of the medicinal liquid, taking it in divided doses, 200 ml each time, twice a day, and taking it for 1 week.

6. A method of taking the Chinese medicinal slices for improving anorexia symptoms after tumor radiotherapy and chemotherapy according to claim 5, characterized in that: The method comprises the following steps: taking a piece of the Chinese herbal medicine slice, soaking the slice in 800 ml of drinking water for 60 minutes, putting the slice and the water into a casserole, first boiling the slice with high heat, then decocting the slice with low heat for 20 minutes, then boiling the slice with high heat, then decocting the slice with low heat for 20 minutes, taking a total of 400-450 ml of the medicinal liquid, taking the medicine in divided doses, 150 ml each time, 3 times a day, and taking the medicine for 1 week.

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