Cell reinfusion device for cell biotherapy

Abstract

The invention belongs to the technical field of medical instruments, and particularly relates to a cell reinfusion device for cell biotherapy, which comprises a constant-temperature box, a placement frame, a swing part and a pipeline heat preservation part, a top cover is arranged on the upper end opening of the constant-temperature box, and a hook is arranged at the lower part of the top cover; one end of a heat preservation hose of the pipeline heat preservation part is fixedly connected to a sealing plug and inserted into a penetrating pipe arranged on the lower portion of the constant-temperature box, and a connecting shaft arranged on the side wall of the constant-temperature box is rotationally connected to a connecting frame of the placement frame. According to the invention, a transfusion bag for cell transfusion is placed in the constant-temperature box for transfusion, in the whole process, liquid medicine is at a proper temperature and is not influenced by the external environment temperature, the temperature of transfusion liquid is ensured, the comfort of cell transfusion is improved, and meanwhile, the constant-temperature box is shaken, so that the transfusion bag in the constant-temperature box shakes together, and the transfusion effect is improved. Long-time standing of liquid medicine in the infusion bag, cell clustering or attachment to the inner wall of the cell infusion bag are avoided, precipitation is effectively avoided, the treatment effect is improved, operation is convenient, and use is convenient.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a cell reinfusion device for cell biological therapy. Background Art

[0002] Cell therapy technology refers to the transplantation or injection of normal or bioengineered human cells into the patient's body. The newly injected cells can replace or repair damaged cells or stimulate and regulate the immune system, and have stronger immune killing functions, thereby achieving the purpose of treating the disease.

[0003] Cell transfusion is an important part of cell therapy technology. Currently, cell transfusion bags are mostly used for cell transfusion. However, due to the biological characteristics of cells, cells in the transfusion suspension are prone to clump or stick to the inner wall of the cell transfusion bag. In the worst case, the cells in the cell transfusion bag cannot be completely transfused to the patient, resulting in cell waste. In the worst case, medical accidents may occur due to cell clusters blocking blood vessels.

[0004] Under current medical conditions, during the cell transfusion process, medical staff are often required to frequently shake the cell solution, which is labor-intensive. In addition, when performing cell transfusions on patients, the cells are left standing for a long time, which can easily lead to precipitation, thus affecting the patient's treatment effect. Summary of the invention

[0005] 1. Technical issues to be resolved In view of the deficiencies in the prior art, the present invention provides a cell reinfusion device for cell biological therapy, which solves the problem that during the cell reinfusion process, medical staff need to frequently shake the cell solution, which is labor-intensive, and the cells are prone to precipitation due to being left stationary for a long time, thus affecting the treatment effect on the patient.

[0006] (II) Technical solution In order to achieve the above-mentioned purpose, the present invention specifically adopts the following technical solutions: A cell reinfusion device for cell biological therapy comprises a thermostatic box, a mounting frame, a swinging member and a pipe insulation member, wherein a top cover is mounted on the upper port of the thermostatic box, a hook is arranged at the lower part of the top cover, one end of the insulation hose of the pipe insulation member is fixedly connected to a sealing plug which is inserted into a through pipe arranged at the lower part of the thermostatic box, and a connecting shaft arranged on the side wall of the thermostatic box is rotatably connected to a connecting frame of the mounting frame, the connecting frame is fixedly connected to a vertical rod through a connecting rod, a hanging plate is arranged at the upper end of the vertical rod, and a resistance plate is arranged at the lower end, and the lower end of a push rod of the swinging member is fixedly connected to the thermostatic box through a connecting seat, and the other end of the push rod is transmission-connected to a transmission rod on an output shaft of a driving motor.

[0007] Furthermore, a visual window is provided on the side wall of the thermostatic box, and a hook is arranged at the middle position of the lower part of the top cover of the upper part of the thermostatic box, a thermostatic heating component is arranged at the part of the lower part of the top cover extending to the inner part of the upper port of the thermostatic box, a handle is fixedly connected to the upper part of the top cover, and a through-tube arranged at the middle part of the lower part of the thermostatic box is connected with the inner cavity of the box body; The connecting shafts arranged on the outer walls on both sides of the thermostatic box are rotatably connected to the shaft seats at the ends of the connecting frames through bearings, and a shaking area for shaking of the box body is reserved between the cross bar on one side of the connecting frame and the side edge of the thermostatic box.

[0008] Furthermore, the upper end of the vertical rod is bent and fixedly connected to the extension of one side of the hanging plate, and the lower end of the vertical rod is bent and fixedly connected to the contact plate, and the hanging plate and the contact plate are both semi-annular, and the sides of the hanging plate and the contact plate that contact the rod body of the infusion stand are fixedly connected with rubber anti-skid lining blocks; One side of the vertical rod is rotatably connected to a connecting rod through a pin shaft, the upper end of the connecting rod is bent and fixedly connected to one side of the limit plate, and one side of the connecting rod is fixedly connected to a driving rod, and a supporting spring plate is arranged between one side of the connecting rod located at the lower part of the driving rod and the connecting rod; The limit plate is arc-shaped and is arranged in cooperation with the hanging plate. The limit plate is arranged on one side of the opening of the hanging plate, and a rubber anti-skid lining block is fixedly connected to the side of the limit plate in contact with the rod body of the infusion stand.

[0009] Furthermore, the pin seat integrally provided at the lower end of the push rod is rotatably connected to the ear plate provided on the connecting seat through a pin, and the connecting part integrally provided at the upper end of the push rod is rotatably connected to one end of the transmission rod through a pin, and the other end of the transmission rod is fixedly connected to the output shaft of the driving motor, and the driving motor is fixedly connected to a cross bar provided on one side of the connecting frame through a motor frame.

[0010] Furthermore, the sealing plug is arranged in cooperation with the through-tube at the lower part of the constant temperature box, and a pipeline cavity is opened on the sealing plug and the thermal insulation hose, the inner diameter of the pipeline cavity is larger than the outer diameter of the infusion pipeline, and the deformation notch opened on the sealing plug and the thermal insulation hose is connected with the pipeline cavity.

[0011] (III) Beneficial effects Compared with the prior art, the present invention provides a cell reinfusion device for cell biological therapy, which has the following beneficial effects: The present invention places a reinfusion bag for cell reinfusion in a constant temperature box for reinfusion. During the whole process, the medicine solution is at an appropriate temperature and is not affected by the external environment temperature, thereby ensuring the temperature of the reinfusion solution and improving the comfort of cell reinfusion. At the same time, the constant temperature box is shaken to shake the reinfusion bag inside it together, thereby preventing the medicine solution in the reinfusion bag from being left still for a long time and the cells from agglomerating or sticking to the inner wall of the cell reinfusion bag, thereby effectively avoiding precipitation and improving the therapeutic effect. The overall structure is simple, the operation is convenient, and it is easy to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a structural schematic diagram of the present invention; Figure 2 It is an exploded view of the thermostatic box in the present invention; Figure 3 It is an exploded view of the mounting frame in the present invention; Figure 4 It is a structural schematic diagram of the swing member in the present invention; Figure 5 It is a schematic diagram of the structure of the pipeline insulation component in the present invention.

[0013] In the figure: 1. Constant temperature box; 101. Visual window; 102. Connecting shaft; 103. Pipe; 104. Top cover; 105. Hook; 106. Handle; 2. Mounting frame; 201. Vertical rod; 202. Connecting rod; 203. Connecting frame; 204. Hanging plate; 205. Resistance plate; 206. Connecting rod; 207. Limiting plate; 208. Driving rod; 209. Support spring plate; 3. Swinging member; 301. Push rod; 3011. Connecting part; 3012. Pin seat; 302. Connecting seat; 303. Transmission rod; 304. Driving motor; 305. Motor frame; 4. Pipe insulation member; 401. Insulation hose; 402. Sealing plug; 403. Deformation notch; 404. Pipe cavity. DETAILED DESCRIPTION

[0014] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0015] Example like Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5As shown, an embodiment of the present invention proposes: a cell reinfusion device for cell biological treatment, including a thermostatic box 1, a mounting frame 2, a swinging member 3 and a pipe insulation member 4, a top cover 104 is mounted on the upper port of the thermostatic box 1, and a hook 105 is arranged at the lower part of the top cover 104, so as to stably place the reinfusion bag of the cell reinfusion in the inner cavity of the box body, and during the cell reinfusion process, the thermostatic box 1 is used to insulate the reinfusion bag and the liquid medicine therein, so that they are at an appropriate temperature and are not affected by the external environment temperature, so as to ensure the temperature of the reinfusion liquid and improve the cell reinfusion temperature. In order to improve the comfort of transfusion and the quality of reinfusion treatment, one end of the insulation hose 401 of the pipeline insulation component 4 is fixedly connected to the sealing plug 402 and inserted into the through pipe 103 set at the lower part of the thermostatic box 1, so as to facilitate the stable installation of the pipeline insulation component 4 to the lower part of the thermostatic box 1, and to insulate and protect the infusion pipeline extending from the inside of the box body, reduce the loss of the temperature of the medicine liquid during the reinfusion process, reduce the influence of the temperature change on the reinfusion medicine liquid, and ensure the smooth progress of the whole reinfusion process, and the connecting shaft 102 set on the side wall of the thermostatic box 1 is rotatably connected to the connecting frame of the mounting frame 2 203, it is convenient to stably install the thermostatic box 1 on the mounting frame 2, so that the two can be stably used together. At the same time, when the thermostatic box 1 is driven by external force during use, it can be smoothly shaken on the connecting frame 203 to prevent the liquid in the reinfusion bag from being left still for a long time, and the cells from agglomerating or sticking to the inner wall of the cell reinfusion bag, which effectively avoids precipitation and improves the treatment effect. The connecting frame 203 is fixedly connected to the vertical rod 201 through the connecting rod 202. The upper end of the vertical rod 201 is provided with a hanging plate 204, and the lower end is provided with a resistance plate 205. It is convenient to stably install the entire mounting frame 2 on the rod body of the infusion stand, so as to achieve stable installation during use, and the lower end of the push rod 301 of the swing member 3 is fixedly connected to the constant temperature box 1 through the connecting seat 302, and the other end of the push rod 301 is transmission-connected with the transmission rod 303 on the output shaft of the driving motor 304, so that during use, the driving motor 304 runs, and the push rod 301 is moved by the transmission rod 303, and then the constant temperature box 1 is driven under the action of the push rod 301, so that the constant temperature box 1 swings on the connecting frame 203 and is stably used.

[0016] like Figure 1 and Figure 2As shown, in some embodiments, a visual window 101 is provided on the side wall of the thermostatic box 1, so that medical personnel can view the status of the reinfusion bag inside the box body in real time, so as to replace or stop the cell reinfusion in time, thereby improving the convenience of use. A hook 105 is arranged at the middle position of the lower part of the top cover 104 on the upper part of the thermostatic box 1, so as to hang the reinfusion bag inside the box body and ensure smooth reinfusion. A thermostatic heating component is arranged on the part of the lower part of the top cover 104 extending to the interior of the upper port of the thermostatic box 1. The thermostatic box 1 is a prior art, and its internal heating and heat preservation are all prior art, so no more details are given. The upper part of the top cover 104 A handle 106 is fixedly connected, which is convenient for direct handholding during use, and the top cover 104 can be quickly disassembled and assembled, which improves the convenience of use. In addition, the through-tube 103 arranged at the middle part of the lower part of the thermostatic box 1 is connected with the internal cavity of the box body, which is convenient for smoothly installing the infusion pipeline at the lower part of the reinfusion bag, so that the reinfusion bag is placed in the thermostatic box 1, and is kept warm during the infusion process, so that it is at a suitable temperature and is not affected by the external environment temperature, thereby ensuring the activity of cells in the liquid medicine and improving the quality of treatment. At the same time, it also ensures that the temperature of the reinfusion liquid is more suitable for the human body, relieves the discomfort during the reinfusion process, and improves the comfort of cell reinfusion; The connecting shaft 102 arranged on the outer walls on both sides of the constant temperature box 1 is rotatably connected to the shaft seat at the end of the connecting frame 203 through a bearing, and a shaking area for the box body to shake is reserved between the cross bar on one side of the connecting frame 203 and the side of the constant temperature box 1, so that the constant temperature box 1 can swing smoothly on the connecting frame 203 when the swinging member 3 is driven, so as to achieve the shaking operation of the return bag in the inner box body.

[0017] like Figure 1 and Figure 3 As shown, in some embodiments, the upper end of the vertical rod 201 is bent and fixedly connected to the extension of one side of the hanging plate 204, and the lower end of the vertical rod 201 is bent and fixedly connected to the contact plate 205, so that the two can be stably installed at both ends of the vertical rod 201, thereby forming a ring body with vertically displaced distribution. When the placement frame 2 is installed on the rod body of the infusion stand, it is only necessary to tilt the vertical rod 201 so that the hanging plate 204 and the contact plate 205 are distributed on both sides of the rod body of the infusion stand, and then move the openings of the hanging plate 204 and the contact plate 205 to the side of the rod body. The openings of the hanging plate 204 and the abutment plate 205 are clamped onto the rod body. At this time, the upper hanging plate 204 is hung on the rod body, and the lower abutment plate 205 abuts against the rod body, so that the entire mounting frame 2 is stably installed on the rod body to ensure stable use. The hanging plate 204 and the abutment plate 205 are both semi-annular, and the sides of the hanging plate 204 and the abutment plate 205 that contact the rod body of the infusion stand are fixedly connected with rubber non-slip lining blocks to increase the friction between the two, so that the mounting frame 2 is stably placed on the rod body of the infusion stand, realizing fast and stable installation operation and improving the convenience of use. One side of the vertical rod 201 is rotatably connected to a connecting rod 206 through a pin shaft. The upper end of the connecting rod 206 is bent and fixedly connected to one side of the limit plate 207, so that the limit plate 207 can be installed on the vertical rod 201 using the connecting rod 206, so that the limit plate 207 can be used in conjunction with the hanging plate 204, and then clamped on the rod body of the infusion stand, further improving the stability of the installation of the placement stand 2, and one side of the connecting rod 206 is fixedly connected to a driving rod 208, and the connecting rod 206 is located between one side of the lower part of the driving rod 208 and the connecting rod 202 A support spring plate 209 is installed. During use, the driving rod 208 can be directly pressed by hand to drive the connecting rod 206 to rotate on the vertical rod 201 with the limit plate 207. The position of the limit plate 207 is adjusted so that the hanging plate 204 can be smoothly hung on the rod body of the infusion stand. At the same time, the support spring plate 209 is used to provide a stable supporting force for the driving rod 208, ensuring that after the placement frame 2 is installed on the rod body, the limit plate 207 can be tightly against the rod body, so as to achieve auxiliary limit fixation and improve the installation stability of the entire placement frame 2; The limiting plate 207 is arc-shaped and is arranged in conjunction with the hanging plate 204. The limiting plate 207 is placed on one side of the opening of the hanging plate 204, and a rubber anti-slip lining block is fixedly connected to the side of the limiting plate 207 that contacts the infusion stand rod body, thereby increasing the friction force at the contact portion between the two and improving the auxiliary fixation effect.

[0018] like Figure 1 and Figure 4 As shown, in some embodiments, the pin seat 3012 integrally provided at the lower end of the push rod 301 is rotatably connected to the ear plate provided on the connecting seat 302 through the pin, and the lower end of the push rod 301 is stably connected to the outer wall of the constant temperature box 1 by using the connecting seat 302, so that the push rod 301 can move smoothly with the constant temperature box 1 during the movement, and at the same time, the push rod 301 and the connecting seat 302 are connected in a rotating manner, which can ensure that appropriate deflection is generated between the two during use, avoid motion interference, and ensure smooth operation, and the connecting part 3011 integrally provided at the upper end of the push rod 301 is rotatably connected to one end of the transmission rod 303 through the pin, and the transmission The other end of the moving rod 303 is fixedly connected to the output shaft of the driving motor 304, and the driving motor 304 is fixedly connected to the cross bar set on one side of the connecting frame 203 through the motor frame 305, so as to stably install the driving motor 304 on the mounting frame 2. During use, it outputs power, moves the push rod 301 through the transmission rod 303, and then pushes the constant temperature box 1 to shake on the connecting frame 203. During the shaking process of the constant temperature box 1, the reinfusion bag placed inside the box body will also shake together. Through uninterrupted shaking, the cells in the medicine solution in the reinfusion bag are prevented from clumping or sticking to the inner wall of the cell reinfusion bag, which effectively avoids precipitation caused by long-term static standing and improves the treatment effect.

[0019] like Figure 1 , Figure 2 and Figure 5 As shown, in some embodiments, the sealing plug 402 is arranged in cooperation with the through-tube 103 at the bottom of the thermostatic box 1, so that the entire pipeline insulation component 4 can be stably installed at the bottom of the thermostatic box 1 by utilizing the cooperation of the sealing plug 402 and the through-tube 103, so as to insulate the infusion pipeline, avoid excessive temperature changes during the transportation of the medicine, ensure the efficiency of the infusion and the quality of treatment, and also improve the comfort of the infusion process and reduce the discomfort of the infusion. In addition, a pipeline cavity 404 is provided on the sealing plug 402 and the thermal insulation hose 401, and the inner diameter of the pipeline cavity 404 is larger than the outer diameter of the infusion pipeline, and the deformation notch 403 provided on the sealing plug 402 and the thermal insulation hose 401 is connected with the pipeline cavity 404, so that when in use, the infusion pipeline can be directly placed in the thermal insulation hose 401 and the pipeline cavity 404 in the sealing plug 402 from the deformation notch 403 by hand, so as to insulate it during the infusion process and slow down the heat dissipation, and the disassembly and assembly operation of the infusion pipeline can be completed quickly, which is convenient and easy to use.

[0020] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A cell reinfusion device for cell biological therapy, comprising a constant temperature box (1), a mounting frame (2), a swing member (3) and a pipeline insulation member (4), characterized in that: A top cover (104) is arranged on the upper end of the thermostatic box (1), a hook (105) is arranged at the lower part of the top cover (104), one end of the heat-insulating hose (401) of the pipeline heat-insulating member (4) is fixedly connected to the sealing plug (402) inserted into the through-tube (103) arranged at the lower part of the thermostatic box (1), and the connecting shaft (102) arranged on the side wall of the thermostatic box (1) is rotatably connected to the connecting frame (203) of the mounting frame (2), the connecting frame (203) is fixedly connected to the vertical rod (201) through a connecting rod (202), a hanging plate (204) is arranged at the upper end of the vertical rod (201), and a contact plate (205) is arranged at the lower end, and the lower end of the push rod (301) of the swing member (3) is fixedly connected to the thermostatic box (1) through a connecting seat (302), and the other end of the push rod (301) is transmission-connected to the transmission rod (303) on the output shaft of the driving motor (304).

2. A cell reinfusion device for cell biotherapy according to claim 1, characterized in that: The thermostatic box (1) is provided with a visual window (101) on the side wall, and a hook (105) is arranged at the middle position of the lower part of the top cover (104) at the upper part of the thermostatic box (1), a thermostatic heating component is arranged at the part of the lower part of the top cover (104) extending to the interior of the upper port of the thermostatic box (1), a handle (106) is fixedly connected to the upper part of the top cover (104), and a through pipe (103) arranged at the middle position of the lower part of the thermostatic box (1) is connected to the internal cavity of the box body.

3. A cell reinfusion device for cell biotherapy according to claim 2, characterized in that: The connecting shafts (102) arranged on the outer walls of both sides of the thermostatic box (1) are rotatably connected to the shaft seats at the ends of the connecting frame (203) via bearings, and a shaking area for shaking of the box body is reserved between the cross bar on one side of the connecting frame (203) and the side edge of the thermostatic box (1).

4. The cell reinfusion device for cell biotherapy according to claim 1, characterized in that: The upper end of the vertical rod (201) is bent and fixedly connected to the extension of one side of the hanging plate (204), and the lower end of the vertical rod (201) is bent and fixedly connected to the contact plate (205), and the hanging plate (204) and the contact plate (205) are both semi-annular, and the sides of the hanging plate (204) and the contact plate (205) that contact the infusion stand rod body are fixedly connected to a rubber anti-skid lining block.

5. The cell reinfusion device for cell biotherapy according to claim 4, characterized in that: One side of the vertical rod (201) is rotatably connected to a connecting rod (206) via a pin shaft, the upper end of the connecting rod (206) is bent and fixedly connected to one side of a limit plate (207), and one side of the connecting rod (206) is fixedly connected to a driving rod (208), and a supporting spring plate (209) is arranged between one side of the connecting rod (206) located at the lower part of the driving rod (208) and the connecting rod (202).

6. The cell reinfusion device for cell biotherapy according to claim 5, characterized in that: The limit plate (207) is arc-shaped and is arranged in cooperation with the hanging plate (204). The limit plate (207) is arranged on one side of the opening of the hanging plate (204), and a rubber anti-skid lining block is fixedly connected to the side of the limit plate (207) that contacts the rod body of the infusion stand.

7. The cell reinfusion device for cell biotherapy according to claim 1, characterized in that: The pin seat (3012) integrally provided at the lower end of the push rod (301) is rotatably connected to an ear plate provided on the connecting seat (302) via a pin, and the connecting portion (3011) integrally provided at the upper end of the push rod (301) is rotatably connected to one end of the transmission rod (303) via a pin, and the other end of the transmission rod (303) is fixedly connected to the output shaft of the drive motor (304), and the drive motor (304) is fixedly connected to a crossbar provided on one side of the connecting frame (203) via a motor frame (305).

8. The cell reinfusion device for cell biotherapy according to claim 1, characterized in that: The sealing plug (402) is arranged in cooperation with the through pipe (103) at the lower part of the thermostatic box (1), and both the sealing plug (402) and the thermal insulation hose (401) are provided with a pipeline cavity (404), the inner diameter of the pipeline cavity (404) is larger than the outer diameter of the infusion pipeline, and the deformation notch (403) provided on the sealing plug (402) and the thermal insulation hose (401) is connected with the pipeline cavity (404).

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