Heating spraying intraperitoneal administration device

Abstract

The invention belongs to the technical field of medical equipment, and particularly relates to a heating spraying intraperitoneal administration device. Comprising a medicine heating unit, a liquid-electricity safety guarantee unit, a liquid medicine atomization forming unit and a circuit control and connection unit. Through close cooperation of all the units, the high-temperature atomization dosing device and the high-pressure injector are connected; efficient liquid feeding, precise temperature control heating, fine atomization and stable circuit management and control external connection are achieved. When intraperitoneal pressurization atomization administration is adopted, the device can fully and efficiently atomize liquid medicine, medicine particles are refined, and the absorption effect of medicine in the intraperitoneal cavity is improved. The medicine can be accurately heated to about 43 DEG C, tumor cells are inhibited by means of thermal therapy, diseases such as intraperitoneal endometrial metastasis cancer and the like are resisted in cooperation with the medicine, the prognosis of patients is improved, the life quality is improved, the cost is reduced, and the progress of an abdominal cavity disease treatment technology is promoted.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical equipment, and in particular relates to a heating spray intraperitoneal drug delivery device. Background Art

[0002] The treatment of peritoneal diseases, especially cancers with peritoneal metastasis, still faces numerous challenges. Although medical researchers have explored various treatment approaches, such as transcatheter intraperitoneal chemotherapy, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy, none have yielded satisfactory clinical results, and a unified consensus guideline for effective treatment has yet to be established.

[0003] As an emerging minimally invasive surgical technique, peritoneal pressurized aerosol chemotherapy (PIPAC) has emerged to treat metastatic cancers within the abdominal cavity, especially when tumors in the ovaries, colon, bladder, and other sites have spread to the peritoneal surface. During PIPAC surgery, a pressurized system is introduced into the patient's abdominal cavity to spray aerosolized chemotherapy drugs onto tumors on the peritoneal surface. This method significantly shortens the duration of the operation, usually taking only about an hour, and can be repeated. It is often used as an adjuvant procedure for systemic chemotherapy. Clinical studies have shown that PIPAC can effectively relieve symptoms such as pain, ascites, and obstructive symptoms caused by peritoneal metastasis, and reduce the side effects of chemotherapy, which has positive significance for improving the quality of life of patients.

[0004] Hyperthermia also plays an important role in cancer treatment. Studies have found that exposing tumor cells to 43°C for one hour can effectively inhibit their growth and even cause irreversible damage, while normal cells can still tolerate 47°C for one hour. This provides a theoretical basis for using temperature-assisted tumor treatment.

[0005] However, existing hyperthermic peritoneal perfusion procedures have significant drawbacks. The procedure is complex and requires large incisions, which not only increases the patient's surgical trauma and pain but also significantly hinders their postoperative recovery. Furthermore, significant drug waste during treatment results in higher medical costs for patients and an unnecessary waste of medical resources.

[0006] In summary, given the current state of the art for treating celiac disease, there is an urgent need for a novel drug delivery device that can overcome the aforementioned challenges, achieve efficient, safe, and economical treatment, and meet the urgent needs of clinical treatment. The present invention, a heated spray intraperitoneal drug delivery device, was developed based on this research and development background, dedicated to addressing the shortcomings of the existing technology and providing a superior solution for the treatment of celiac disease. Summary of the Invention

[0007] In view of this, the core purpose of the present invention is to overcome the many shortcomings of existing intraperitoneal drug delivery technology and provide an innovative heated spray intraperitoneal drug delivery device. Specifically, the device aims to achieve the following key goals: when using intraperitoneal pressurized atomization for treatment, it ensures that the drug solution can be fully and efficiently atomized, so that the drug particles are refined to an ideal state, thereby greatly improving the absorption effect of the drug in the peritoneal cavity and enhancing the effectiveness of the treatment; at the same time, during the drug atomization process, the drug can be accurately heated to about 43°C, making full use of the inhibitory effect of hyperthermia on tumor cells, synergizing the drug effect to fight tumors together, and bringing more targeted and efficient treatment methods to patients with abdominal diseases, especially patients with peritoneal endometrial metastasis of cancer, effectively improving the patient's treatment prognosis, improving their quality of life, and reducing medical costs and resource waste, and promoting the advancement of abdominal disease treatment technology.

[0008] In order to achieve the above object, the present invention provides a heating spray intraperitoneal drug delivery device, comprising:

[0009] The drug heating unit is used to heat the drug solution after it enters the heating area, and to stably control the drug solution temperature within a set range through a temperature monitoring and control mechanism, so as to achieve a synergistic effect of thermal therapy and drug treatment;

[0010] The hydraulic and electrical safety assurance unit has the function of realizing safe conversion and effective isolation between the liquid circuit and the electrical circuit during the flow of the liquid, preventing the liquid and the circuit from interfering with each other and causing safety problems;

[0011] The drug liquid atomization unit converts the incoming drug liquid into a spray form with a particle size distribution to ensure that the drug can be fully dispersed and absorbed;

[0012] The circuit control and connection unit is responsible for providing a stable power supply for the device, controlling the heating operation, and realizing electrical connection with external equipment.

[0013] Furthermore, the medicine heating unit includes a PTC ceramic heating tube, a temperature sensor, a heating tube insulating gasket, a heating tube locking nut, a heating tube circuit conversion joint, and a main circuit board; wherein, the PTC ceramic heating tube is used to generate heat to heat the medicine, the temperature sensor is arranged near the PTC ceramic heating tube to detect the temperature of the heating space and transmit the signal to the microprocessor chip on the main circuit board, the heating tube insulating gasket is installed on the PTC ceramic heating tube and the temperature sensor and passes through the liquid-electric separation table to act as an insulator, the heating tube locking nut locks the PTC ceramic heating tube and the temperature sensor on the liquid-electric separation table, the heating tube circuit conversion joint is connected to the PTC ceramic heating tube circuit to realize circuit conversion or connect an external power supply to enable the device to operate at a 12V working voltage, and the main circuit board controls the operation of the PTC ceramic heating tube according to the temperature sensor signal to keep the temperature in the heating space between 43±0.5℃.

[0014] Furthermore, the hydraulic-electric safety assurance unit includes a hydraulic-electric conversion valve, a hydraulic-electric conversion valve pressure cover, a contact seat, a static contact, a moving contact, a hydraulic-electric separation platform, a sealing gasket under the separation platform, a sealing gasket on the separation platform, and a liquid inlet pipe sealing ring; the hydraulic-electric conversion valve is made of silicone rubber elastomer, which deforms under the action of the drug liquid pressure to make the moving contact contact with the static contact to achieve circuit conduction, and is fixed to the hydraulic-electric separation platform through the hydraulic-electric conversion valve pressure cover; the hydraulic-electric separation platform is made of insulating and corrosion-resistant materials, and its internal channel size is adapted to the PTC ceramic heating tube and the temperature sensor. The PTC ceramic heating tube and the temperature sensor pass through its internal channel, and a sealing gasket under the separation platform and a sealing gasket on the separation platform are respectively arranged between it and the bottom cover, upper cover, and lower cover, and are connected to the liquid inlet pipe through the liquid inlet pipe sealing ring.

[0015] Furthermore, the liquid medicine atomization forming unit includes a main body, an upper sealing ring on the main body, a lower sealing ring on the main body, a core rod, a spring, a core, a nozzle, a nozzle sealing ring, and a protective cap; there is a core rod outer channel between the main body and the core rod, which is used to receive the liquid medicine from the bottom cover and transport it to the nozzle; the upper sealing ring on the main body and the lower sealing ring on the main body are respectively installed on the upper and lower parts of the main body to achieve sealing; the core rod is located inside the main body, and a core rod inner channel and other channels are formed between the core rod and the main body to guide the flow of liquid medicine; the spring is installed on the core, and controls the opening and closing of the nozzle channel of the nozzle by the core when there is no liquid medicine and when high-pressure liquid medicine is injected; the core is located inside the core outer channel, and moves under the action of liquid medicine pressure to control the opening and closing of the nozzle channel of the nozzle and accelerate and collide the liquid medicine to form fine droplets; the nozzle is provided with a nozzle channel with a diameter of less than 0.2 mm to spray the accelerated fine droplets to form a spray, the nozzle sealing ring is installed around the nozzle to achieve sealing, and the protective cap is located outside the nozzle to play a protective role.

[0016] Furthermore, the circuit control and connection unit includes a main circuit board, a temperature display circuit board, an insulating gasket for the temperature display circuit board, an upper cover, a window cover, a TYPEC plug, a lower cover, a liquid inlet pipe, a Luer connector, a top cover, a top cover sealing gasket, and a Luer connector sealing plug; the main circuit board receives a temperature sensor signal to control the operation of the heating unit, and the temperature display circuit board is connected to the main circuit board to display the temperature information of the heating space; the insulating gasket for the temperature display circuit board is installed between the temperature display circuit board and the upper cover to act as an insulator; the upper cover and the lower cover together constitute the outer shell of the circuit compartment, and are connected to the insulating gasket for the temperature display circuit board and the window cover; the TYPEC plug is used to connect an external power supply; the lower end of the liquid inlet pipe is connected to the liquid-electric separation table through a liquid inlet pipe sealing ring, and the upper end passes through the Luer connector sealing plug and is adhered to the Luer connector; the top cover passes through the top cover sealing gasket and is adhered to the lower cover and the upper cover; the Luer connector sealing plug is installed at the connection between the Luer connector and the liquid inlet pipe to achieve sealing; the Luer connector is used to connect an external infusion device.

[0017] The present invention adopts the above technical solution, which has at least the following beneficial effects:

[0018] 1. Improve therapeutic effects: By heating the drug to about 43°C and combining it with the inhibitory effect of hyperthermia on tumor cells, a synergistic effect is produced with drug treatment, which can more effectively inhibit the growth of tumor cells in the peritoneal cavity, improve the therapeutic effect of diseases such as peritoneal endothelial metastasis cancer, bring better treatment prognosis to patients, and increase the possibility of recovery.

[0019] 2. Optimize drug absorption: The drug solution can be fully atomized, and the median particle size of the spray can reach 18±25% microns, so that the drug is evenly dispersed in the form of tiny particles, greatly increasing the contact area between the drug and the diseased tissue in the abdominal cavity, promoting drug absorption, improving drug utilization, and reducing drug waste, thereby reducing patients' drug costs and social medical resource consumption.

[0020] 3. Ensure safe use: It adopts 12V working voltage and uses liquid-electric separation technology to effectively avoid safety hazards such as leakage, ensure the safety of patients and medical staff during use, reduce the risk of medical accidents, and provide a safe and reliable operating environment for intraperitoneal drug administration.

[0021] 4. Precise temperature control: With the help of temperature sensors and microprocessor chips, the drug heating temperature can be accurately controlled between 43±0.5℃, ensuring the stability and reliability of the thermal therapy effect, avoiding the impact of excessively high or low temperatures on the treatment effect, and making the treatment process more scientific and standardized.

[0022] 5. Stable device performance: The rational design of each unit and the tight connection and effective sealing between components ensure the stability and durability of the device. For example, the liquid-electric separation table and related sealing gaskets ensure the stable isolation of the liquid and electrical circuits. The heating tube lock nut and other components ensure the stable installation of the heating element and sensor, reducing the probability of device failure and maintenance costs, and promoting the long-term stable operation of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0024] Figure 1 Schematic diagram of the heating spray intraperitoneal drug delivery device of the present invention;

[0025] Figure 2 This is an exploded view of the heated spray intraperitoneal drug delivery device of the present invention;

[0026] Figure 3This is one of the structural schematic diagrams of the present invention having a medicine heating unit;

[0027] Figure 4 This is the second structural diagram of the present invention having a medicine heating unit;

[0028] Figure 5 This is the third structural diagram of the present invention having a medicine heating unit;

[0029] Figure 6 It is a schematic diagram of the structure of the hydraulic and electrical safety protection unit of the present invention;

[0030] Figure 7 This is one of the structural schematic diagrams of the present invention having a liquid medicine atomization forming unit;

[0031] Figure 8 This is the second structural diagram of the present invention having a liquid medicine atomization forming unit;

[0032] Figure 9 It is a schematic diagram of the circuit control and connection unit structure of the present invention.

[0033] Figure: 1, PTC ceramic heating tube; 101, temperature sensor; 102, heating tube insulation gasket; 103, heating tube lock nut; 104, heating tube circuit conversion joint; 105, main circuit board; 106, temperature display circuit board; 107, temperature display circuit board insulation gasket; 108, upper cover; 109, window cover; 110, hydraulic-electric conversion valve; 111, hydraulic-electric conversion valve gland; 112, contact seat; 113, static contact; 114, dynamic contact; 115, TYPEC plug; 116, lower cover; 2, main body; 201, main body upper sealing ring; 202, main body lower sealing ring; 203, Core rod; 204, spring; 205, core; 206, nozzle; 207, nozzle sealing ring; 208, protective cap; 3, liquid-electric separation platform; 301, sealing gasket under the separation platform; 302, sealing gasket on the separation platform; 303, liquid inlet pipe sealing ring; 304, liquid inlet pipe; 305, top cover sealing gasket; 306, top cover; 307, Luer connector sealing plug; 308, Luer connector; 309, liquid inlet elbow; 310, heating space; 4, bottom cover; T1, core rod outer channel; T2, core rod inner channel; T3, core outer channel; T4, core side channel; T5, swirl channel; T6, nozzle channel. DETAILED DESCRIPTION

[0034] Exemplary embodiments will be described in detail herein, examples of which are illustrated in the accompanying drawings. In the following description, when referring to the drawings, like numbers in different figures represent like or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments are not intended to represent all possible embodiments consistent with the present invention. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the present invention, as detailed in the appended claims.

[0035] See also Figure 1 and Figure 2 As shown, this embodiment provides a heating spray intraperitoneal drug delivery device, comprising:

[0036] The drug heating unit is used to heat the drug solution after it enters the heating area, and to stably control the drug solution temperature within a set range through a temperature monitoring and control mechanism, so as to achieve a synergistic effect of thermal therapy and drug treatment;

[0037] The hydraulic and electrical safety assurance unit has the function of realizing safe conversion and effective isolation between the liquid circuit and the electrical circuit during the flow of the liquid, preventing the liquid and the circuit from interfering with each other and causing safety problems;

[0038] The drug liquid atomization unit converts the incoming drug liquid into a spray form with a particle size distribution to ensure that the drug can be fully dispersed and absorbed;

[0039] The circuit control and connection unit is responsible for providing a stable power supply for the device, controlling the heating operation, and realizing electrical connection with external equipment.

[0040] In this embodiment, the solution connects a high-temperature atomizer to a high-pressure syringe, and under the action of liquid pressure, the circuit is connected through a liquid-to-electric conversion valve. The excellent liquid-to-electric separation technology ensures that the circuit and liquid circuit are always safely protected. Once the circuit is connected, the heating function begins to work and heat the medicine. The circuit operates at a voltage of 12V and uses a PTC ceramic heating tube for heating, which is highly efficient and very safe. At the same time, an internal temperature sensor transmits the temperature signal to the microprocessor chip on the circuit board. Under the action of the microprocessor chip, the medicine is always heated to 43±0.5℃.

[0041] The liquid is pressed from a thick pipe into a thin pipe through pressure to create a high-speed water flow. When the high-speed water flow hits an obstacle, it breaks into small droplets, and then passes through an extremely fine liquid outlet, converting the liquid into fine mist, which is sprayed out from the applicator and directly acts on the lesion to achieve a good therapeutic effect.

[0042] like Figure 2 、 Figure 3 、 Figure 4 and Figure 5As shown, the medicine heating unit in this embodiment includes a PTC ceramic heating tube 1, a temperature sensor 101, a heating tube insulating gasket 102, a heating tube lock nut 103, a heating tube circuit conversion joint 104, and a main circuit board 105; wherein, the PTC ceramic heating tube 1 is used to generate heat to heat the medicine, the temperature sensor 101 is arranged near the PTC ceramic heating tube 1 to detect the temperature of the heating space and transmit the signal to the microprocessor chip on the main circuit board 105, the heating tube insulating gasket 102 is installed on the PTC ceramic heating tube 1 and the temperature sensor 101 and passes through the liquid-electric separation table 3 to act as an insulator, the heating tube lock nut 103 locks the PTC ceramic heating tube 1 and the temperature sensor 101 on the liquid-electric separation table 3, the heating tube circuit conversion joint 104 is connected to the PTC ceramic heating tube 1 circuit to realize circuit conversion or connect an external power supply to enable the device to operate at a 12V working voltage, and the main circuit board 105 controls the PTC ceramic heating tube 1 according to the signal of the temperature sensor 101 to keep the temperature in the heating space between 43±0.5℃.

[0043] like Figure 3 、 Figure 4 and Figure 5 As shown, when the medication enters the liquid inlet elbow 309 through the liquid inlet pipe 304, it directly impacts the hydraulic-electric conversion valve 110 after exiting the liquid inlet elbow 309. Under the action of liquid pressure, the hydraulic-electric conversion valve 110, made of a silicone rubber elastomer, deforms and bulges upward, squeezing the movable contact 114, causing it to bend upward and contact the stationary contact 113, thereby completing the circuit and enabling the normal operation of the heating tube 1. The hydraulic-electric conversion valve 110 is securely fixed to the hydraulic-electric separation platform 3 via the hydraulic-electric conversion valve gland 111, ensuring the safety of the fluid and electrical circuits. When the medication impacts the hydraulic-electric conversion valve 110 and returns to the heating space 310, it contacts the PTC ceramic heating tube 1, causing the medication to heat. The temperature sensor 101 detects the temperature of the heating space 310 and transmits a signal to the microprocessor chip on the main circuit board 105. The microprocessor chip transmits instructions to the PTC ceramic heating tube 1, ensuring that the temperature within the heating space 310 is consistently maintained between 43±0.5°C.

[0044] like Figure 6As shown, the hydraulic and electrical safety assurance unit in this embodiment includes a hydraulic and electrical conversion valve 110, a hydraulic and electrical conversion valve cover 111, a contact seat 112, a static contact 113, a dynamic contact 114, a hydraulic and electrical separation platform 3, a sealing gasket 301 under the separation platform, a sealing gasket 302 on the separation platform, and a liquid inlet pipe sealing ring 303; the hydraulic and electrical conversion valve 110 is made of a silicone rubber elastomer, and deforms under the pressure of the drug liquid to make the dynamic contact 114 contact with the static contact 113 to achieve circuit conduction, and through the hydraulic and electrical conversion The valve pressure cover 111 is tightly fixed to the liquid-electric separation platform 3; the liquid-electric separation platform 3 is made of insulating and corrosion-resistant materials, and the size of its internal channel is adapted to the PTC ceramic heating tube 1 and the temperature sensor 101. The PTC ceramic heating tube 1 and the temperature sensor 101 pass through its internal channel. A sealing gasket 301 under the separation platform and a sealing gasket 302 on the separation platform are respectively provided between it and the bottom cover 4, the upper cover 108, and the lower cover 116, and are connected to the liquid inlet pipe 304 through a liquid inlet pipe sealing ring 303.

[0045] like Figure 6 As shown, the PTC ceramic heating tube 1 and the temperature sensor 101 are assembled with a heating tube insulating gasket 102, which is then passed through the liquid-electric separation platform 3 and locked with a heating tube lock nut 103. There is a separation platform lower sealing gasket 301 between the liquid-electric separation platform 3 and the bottom cover 4, and a separation platform upper sealing gasket 302 between the liquid-electric separation platform 3 and the upper cover 108 and the lower cover 116.

[0046] like Figure 7 and Figure 8 As shown, the liquid medicine atomization forming unit in this embodiment includes a main body 2, an upper sealing ring 201 of the main body, a lower sealing ring 202 of the main body, a core rod 203, a spring 204, a core 205, a nozzle 206, a nozzle sealing ring 207, and a protective cap 208; there is a core rod outer channel T1 between the main body 2 and the core rod 203, which is used to receive the liquid medicine from the bottom cover 4 and transport it to the nozzle 206; the upper sealing ring 201 of the main body and the lower sealing ring 202 of the main body are respectively installed at the upper and lower parts of the main body 2 to achieve sealing; the core rod 203 is located inside the main body 2, and a core rod inner channel T2 is formed between the main body 2 and the main body 2 to guide the liquid medicine flow The spring 204 is installed on the core 205, and controls the opening and closing of the nozzle channel T6 of the nozzle 206 by the core 205 when there is no liquid medicine and when high-pressure liquid medicine is injected respectively; the core 205 is located inside the core outer channel T3, and moves under the action of the liquid medicine pressure to control the opening and closing of the nozzle channel T6 of the nozzle 206 and accelerate and collide the liquid medicine to form fine droplets; the nozzle 206 is provided with a nozzle channel T6 with a diameter of less than 0.2 mm to spray the accelerated fine droplets to form a spray, and the nozzle sealing ring 207 is installed around the nozzle 206 to achieve sealing, and the protective cap 208 is located outside the nozzle 206 to play a protective role.

[0047] like Figure 7 and Figure 8As shown, the heated liquid medicine enters the main body 2 through the bottom cover 4. A core rod outer channel T1 is formed between the main body 2 and the core rod 203. The liquid medicine passes through the core rod outer channel T1, enters the core rod inner channel T2, and then enters the core outer channel T3. This core outer channel T3 contains a core 205 and a spring 204. When there is no liquid medicine, the core 205, under the pressure of the spring 204, can support the nozzle channel T6 of the nozzle 206 to prevent the liquid medicine from flowing out. When high-pressure liquid medicine is injected, the liquid medicine passes through the gap between the core 205 and the core 205, accelerating the liquid medicine and turning it into extremely fine droplets. This process generates a reverse force on the core 205, compressing the spring 204, opening the nozzle channel T6 of the nozzle 206 to form a swirl channel T5. The accelerated liquid medicine collides more violently when passing through the fan-shaped groove at the top of the core 205, forming finer droplets. The nozzle channel diameter of the nozzle 206 is less than 0.2 mm, so that the fine droplets in the swirl chamber T5 are accelerated again to rush out of the nozzle channel T6 and combine with the external gas to form a spray.

[0048] like Figure 9 As shown, the circuit control and connection unit in this embodiment includes a main circuit board 105, a temperature display circuit board 106, a temperature display circuit board insulating gasket 107, an upper cover 108, a window cover 109, a TYPEC plug 115, a lower cover 116, a liquid inlet pipe 304, a Luer connector 308, a top cover 306, a top cover sealing gasket 305, and a Luer connector sealing plug 307; the main circuit board 105 receives a signal from the temperature sensor 101 to control the operation of the heating unit, and the temperature display circuit board 106 is connected to the main circuit board 105 to display the temperature information of the heating space; the temperature display circuit board insulating gasket 107 is installed between the temperature display circuit board 106 and the upper cover 10 8 plays an insulating role; the upper cover 108 and the lower cover 116 together form the circuit compartment shell, and are connected to the temperature display circuit board insulating gasket 107 and the window cover 109; the TYPEC plug 115 is used to connect an external power supply; the lower end of the liquid inlet pipe 304 is connected to the liquid-electric separation table 3 through the liquid inlet pipe sealing ring 303, and the upper end passes through the Luer connector sealing plug 307 and is adhered to the Luer connector 308; the top cover 306 passes through the top cover sealing gasket 305 and is adhered to the lower cover 116 and the upper cover 108; the Luer connector sealing plug 307 is installed at the connection part between the Luer connector 308 and the liquid inlet pipe 304 to achieve sealing; the Luer connector 308 is used to connect an external infusion device.

[0049] like Figure 9As shown, the circuit compartment houses the main circuit board 105, the temperature display circuit board 106, and the liquid inlet pipe 304. The lower end of the liquid inlet pipe 304 is connected to the liquid-electric separation platform 3 via a liquid inlet pipe sealing ring 303. The upper end of the liquid inlet pipe 304 passes through a Luer connector sealing plug 307 and is bonded to a Luer connector 308. The outer portion of the circuit compartment is assembled from the lower cover 116 and the upper cover 108. The temperature display circuit board insulating gasket 107 is assembled with the upper cover 108 and then bonded to the window cover 109. The top cover 306 passes through the top cover sealing gasket 305 and is bonded to the lower cover 116 and the upper cover 108. Sealing adhesive is injected between the upper and lower covers 108 and 116.

[0050] The above embodiment provides a heated spray intraperitoneal drug delivery device, which mainly includes a drug heating unit, a liquid-electric safety unit, a drug liquid atomization forming unit and a circuit control and connection unit. It is connected to the high-pressure syringe through a high-temperature atomizer, and the circuit is connected by a liquid-electric conversion valve. A PTC ceramic heating tube with a working voltage of 12V is used to heat the drug to 43±0.5°C, and precise temperature control is achieved with the help of a temperature sensor and a microprocessor chip. In terms of liquid-electric safety, the liquid-electric separation table and related components ensure the safe isolation of the liquid circuit. The drug liquid is sprayed through a specific pipeline structure, and the specific components of each unit are closely coordinated, from liquid inlet, heating, atomization to circuit control and connection with external equipment, to achieve efficient and safe operation of the device during intraperitoneal drug delivery, providing an effective technical means for the treatment of abdominal diseases.

[0051] Although the embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are exemplary and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A heating spray intraperitoneal drug delivery device, characterized in that: include: The drug heating unit is used to heat the drug solution after it enters the heating area, and to stably control the temperature of the drug solution within a set range through a temperature monitoring and control mechanism, so as to achieve a synergistic effect of thermal therapy and drug therapy; The hydraulic and electrical safety assurance unit has the function of realizing safe conversion and effective isolation of the liquid circuit and the circuit during the flow of the liquid, preventing the liquid and the circuit from interfering with each other and causing safety problems; The drug liquid atomization unit converts the incoming drug liquid into a spray form with a particle size distribution to ensure that the drug can be fully dispersed and absorbed; The circuit control and connection unit is responsible for providing a stable power supply to the device, controlling the heating operation, and realizing electrical connection with external equipment.

2. The heating spray intraperitoneal drug delivery device according to claim 1, characterized in that; The medicine heating unit comprises a PTC ceramic heating tube (1), a temperature sensor (101), a heating tube insulating gasket (102), a heating tube lock nut (103), a heating tube circuit conversion joint (104), and a main circuit board (105); wherein the PTC ceramic heating tube (1) is used to generate heat to heat the medicine, the temperature sensor (101) is arranged near the PTC ceramic heating tube (1) to detect the temperature of the heating space and transmit a signal to the microprocessor chip on the main circuit board (105), and the heating tube insulating gasket (102) is installed between the PTC ceramic heating tube (1) and the temperature sensor (101). The heating tube lock nut (103) locks and fixes the PTC ceramic heating tube (1) and the temperature sensor (101) on the liquid-electric separation platform (3); the heating tube circuit conversion joint (104) is connected to the circuit of the PTC ceramic heating tube (1) to realize circuit conversion or connect an external power supply so that the device operates at a working voltage of 12V; the main circuit board (105) controls the operation of the PTC ceramic heating tube (1) according to the signal of the temperature sensor (101) so that the temperature in the heating space is maintained between 43±0.5°C.

3. The heating spray intraperitoneal drug delivery device according to claim 1, characterized in that: The hydraulic-electric safety assurance unit comprises a hydraulic-electric conversion valve (110), a hydraulic-electric conversion valve gland (111), a contact piece seat (112), a static contact piece (113), a moving contact piece (114), a hydraulic-electric separation platform (3), a sealing gasket (301) under the separation platform, a sealing gasket (302) on the separation platform, and a liquid inlet pipe sealing ring (303); the hydraulic-electric conversion valve (110) is made of a silicone rubber elastomer, and deforms under the pressure of the drug liquid to make the moving contact piece (114) contact with the static contact piece (113) to realize circuit conduction, and the hydraulic-electric conversion valve gland (111) is used to connect the moving contact piece (114) to the static contact piece (113). 1) is fixed to the liquid-electric separation table (3); the liquid-electric separation table (3) is made of insulating and corrosion-resistant materials, the size of its internal channel is compatible with the PTC ceramic heating tube (1) and the temperature sensor (101), the PTC ceramic heating tube (1) and the temperature sensor (101) pass through its internal channel, and a sealing gasket (301) under the separation table and a sealing gasket (302) on the separation table are respectively arranged between it and the bottom cover (4), the upper cover (108), and the lower cover (116), and are connected to the liquid inlet pipe (304) through the liquid inlet pipe sealing ring (303).

4. The heating spray intraperitoneal drug delivery device according to claim 1, characterized in that: The liquid medicine atomization forming unit comprises a main body (2), an upper sealing ring (201) of the main body, a lower sealing ring (202) of the main body, a core rod (203), a spring (204), a core (205), a nozzle (206), a nozzle sealing ring (207), and a protective cap (208); an outer core rod channel (T1) is provided between the main body (2) and the core rod (203) for receiving liquid medicine from the bottom cover (4) and conveying it to the nozzle (206); the upper sealing ring (201) of the main body and the lower sealing ring (202) of the main body are respectively installed at the upper and lower parts of the main body (2) to achieve sealing; the core rod (203) is located inside the main body (2) and forms an inner core rod channel (T2) between the core rod (203) and the main body (2) so as to guide the liquid medicine into the nozzle (206); The spring (204) is installed on the core (205) to control the opening and closing of the nozzle channel (T6) of the nozzle (206) by the core (205) when there is no liquid medicine and when there is high-pressure liquid medicine injected; the core (205) is located inside the core outer channel (T3) and moves to control the opening and closing of the nozzle channel (T6) of the nozzle (206) under the action of the liquid medicine pressure to accelerate and collide the liquid medicine to form fine droplets; the nozzle (206) is provided with a nozzle channel (T6) with a diameter less than 0.2 mm to spray the accelerated fine droplets to form a spray, the nozzle sealing ring (207) is installed around the nozzle (206) to achieve sealing, and the protective cap (208) is located outside the nozzle (206) to play a protective role.

5. The heating spray intraperitoneal drug delivery device according to claim 1, characterized in that: The circuit control and connection unit comprises a main circuit board (105), a temperature display circuit board (106), an insulating gasket for the temperature display circuit board (107), an upper cover (108), a window cover (109), a TYPEC plug (115), a lower cover (116), a liquid inlet pipe (304), a Luer connector (308), a top cover (306), a top cover sealing gasket (305), and a Luer connector sealing plug (307); the main circuit board (105) receives a signal from the temperature sensor (101) to control the operation of the heating unit; the temperature display circuit board (106) is connected to the main circuit board (105) to display the temperature information of the heating space; the insulating gasket for the temperature display circuit board (107) is installed between the temperature display circuit board (106) and the upper cover (108). The upper cover (108) and the lower cover (116) together form a circuit compartment housing and are connected to the temperature display circuit board insulating gasket (107) and the window cover (109); the TYPEC plug (115) is used to connect an external power source; the lower end of the liquid inlet pipe (304) is connected to the liquid-electric separation table (3) through the liquid inlet pipe sealing ring (303), and the upper end passes through the Luer connector sealing plug (307) and is adhered to the Luer connector (308); the top cover (306) passes through the top cover sealing gasket (305) and is adhered to the lower cover (116) and the upper cover (108); the Luer connector sealing plug (307) is installed at the connection between the Luer connector (308) and the liquid inlet pipe (304) to achieve sealing; the Luer connector (308) is used to connect an external infusion device.

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