In vitro control device, ventricular assist system, and bubble discharge control method

Abstract

The invention discloses an in-vitro control device, a ventricular assist system and a bubble discharge control method, and relates to the technical field of ventricular assist. The in-vitro control device is applied to the ventricular assist system and comprises a distance acquisition module and a bubble discharge module, and the distance acquisition module is used for acquiring a bubble safety distance and a current bubble movement distance in response to detection of bubbles in a perfusion pipeline; and the bubble discharging module is used for comparing the bubble movement distance with the bubble safety distance so as to control to discharge the bubbles based on a comparison result. According to the scheme disclosed by the invention, the problem of poor bubble discharge control of the in-vitro control device can be solved.

Description

Technical Field

[0001] The present application relates to the field of ventricular assist technology, and in particular to an extracorporeal control device, a ventricular assist system, and a method for controlling bubble discharge. Background Art

[0002] Usually, during the operation of the ventricular assist system, in order to prevent blood from entering the catheter pump and causing the pump to stop, the catheter pump is connected to the perfusion line and the perfusion fluid is used to flush the internal gap of the catheter pump. However, during the operation of the entire system, air may enter the perfusion line. Therefore, it is necessary to detect whether there are bubbles in the perfusion line and issue a bubble alarm.

[0003] At present, the solution in the related technology is to set a bubble sensor in the ventricular assist system to detect whether there are bubbles in the perfusion line. Bubbles generally pass through the bubble sensor in a very short time, so the corresponding bubble alarm is triggered for a short time and disappears. However, after the bubble passes through the bubble sensor, it may still remain in the flow channel. If the bubble alarm disappears, the operator will not be able to know the current bubble situation, which may lead to the risk of bubbles entering the human body, causing safety hazards. Summary of the invention

[0004] The present application provides an extracorporeal control device, a ventricular assist system, and a method for controlling bubble discharge, which can solve the problem of poor bubble discharge control of the extracorporeal control device. The technical solution is as follows:

[0005] In a first aspect, an extracorporeal control device is provided, which is applied to a ventricular assist system, and the extracorporeal control device comprises:

[0006] a distance acquisition module, for acquiring a bubble safety distance and a current bubble movement distance in response to detecting bubbles in the perfusion pipeline;

[0007] The bubble discharge module is used to compare the bubble movement distance and the bubble safety distance, so as to control the discharge of the bubble based on the comparison result.

[0008] In a possible implementation, the distance acquisition module is further used to obtain a current perfusion flow value in response to detecting bubbles in the perfusion pipeline, so as to determine the bubble safety distance based on the current perfusion flow value and using a preset safety rule; wherein,

[0009] The preset safety rules include a preset constraint relationship between the perfusion flow value and the bubble safety distance, and a preset safety distance value range corresponding to the bubble safety distance. The preset constraint relationship between the perfusion flow value and the bubble safety distance is that the larger the perfusion flow value, the smaller the bubble safety distance.

[0010] In a possible implementation, the distance acquisition module is specifically configured to determine the bubble safety distance based on the current perfusion flow value and a preset safety distance value range by utilizing a preset constraint relationship between the perfusion flow value and the bubble safety distance.

[0011] In a possible implementation, the distance acquisition module is further configured to obtain the bubble movement distance based on the radius of the perfusion pipeline and the perfusion flow value by using a preset movement distance algorithm.

[0012] In a possible implementation, the distance acquisition module is specifically used to calculate the bubble movement distance corresponding to each preset time interval based on the radius of the perfusion pipeline and the perfusion flow value according to the preset time interval;

[0013] The bubble movement distance at each preset time interval is cumulatively calculated to obtain the current bubble movement distance.

[0014] In a possible implementation, the bubble discharge module is further configured to output a prompt message for disconnecting a connector in response to the bubble movement distance being greater than or equal to a bubble safety distance, wherein the connector is disposed between the perfusion pipeline and the catheter pump;

[0015] Get the perfusion pressure value;

[0016] In response to the infusion pressure value being less than a preset pressure threshold, a pressurization process is performed to control the discharge of the bubbles.

[0017] In a possible implementation, the bubble discharge module is further configured to increase the motor speed in response to the injection pressure value being less than a preset pressure threshold;

[0018] In response to the preset termination condition being met, a prompt message for completing the connection operation is output.

[0019] In a possible implementation, the bubble discharge module is used to maintain the motor speed in response to the bubble movement distance being less than the bubble safety distance.

[0020] In a possible implementation, the extracorporeal control device further includes an information display module;

[0021] The information display module is used to display prompt information and processing progress indicators.

[0022] In a possible implementation, the in vitro control device further includes a bubble detection module, a pressure detection module, and a motor speed adjustment module;

[0023] The bubble detection module is used to detect bubbles in the perfusion pipeline;

[0024] The pressure detection module is used to detect the perfusion pressure value;

[0025] The motor speed adjustment module is used to adjust the motor speed based on the detection result of the perfusion pressure value.

[0026] In a second aspect, a ventricular assist system is provided, the ventricular assist system comprising a catheter pump, a perfusion pump, a perfusion circuit, and an extracorporeal control device as described in any one of the above aspects and implementations;

[0027] The catheter pump is used to assist in pumping blood;

[0028] The perfusion pump is used to pump the perfusion fluid to the catheter pump through the perfusion pipeline;

[0029] The perfusion pipeline is disconnected and connected with the catheter pump through a joint.

[0030] In a third aspect, a method for controlling bubble discharge is provided, the method being applied to an in vitro control device as described in any one of the above aspects and implementations, the method comprising:

[0031] In response to detecting bubbles in the perfusion line, obtaining a bubble safety distance and a current bubble movement distance;

[0032] The bubble movement distance and the bubble safety distance are compared and processed to control the discharge of the bubble based on the comparison result.

[0033] In a fourth aspect, a computer-readable storage medium is provided, wherein at least one instruction is stored in the storage medium, and the at least one instruction is loaded and executed by a processor to implement the method of the above-mentioned aspect and any possible implementation manner.

[0034] In a fifth aspect, a programmable logic controller is provided, comprising:

[0035] at least one processor; and

[0036] a memory communicatively connected to the at least one processor; wherein,

[0037] The memory stores instructions that can be executed by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to perform the method of any possible implementation manner and the aspects described above.

[0038] The beneficial effects of the technical solution provided by this application include at least:

[0039] It can be seen from the above technical solution that in the embodiment of the present application, the distance acquisition module of the extracorporeal control device can respond to the detection of bubbles in the perfusion pipeline to obtain the bubble safety distance and the current bubble movement distance, and the bubble discharge module of the extracorporeal control device compares and processes the bubble movement distance and the bubble safety distance to control the discharge of the bubbles based on the result of the comparison. Since the discharge of bubbles in the perfusion pipeline can be controlled by comparing the size relationship between the bubble movement distance and the bubble movement distance, the bubbles in the perfusion pipeline can be effectively discharged while ensuring the stability and reliability of the overall perfusion operation.

[0040] It should be understood that the content described in this section is not intended to identify the key or important features of the embodiments of the present application, nor is it intended to limit the scope of the present application. Other features of the present application will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0042] Figure 1 is a schematic diagram of the architecture of an in vitro control device provided by an embodiment of the present application;

[0043] Figure 2 is a structural schematic diagram of a ventricular assist system provided by another embodiment of the present application;

[0044] Figure 3 is a schematic diagram of the structure of a bubble sensor in an in vitro control device provided by another embodiment of the present application;

[0045] Figure 4 is a side view of a bubble sensor in an in vitro control device provided by another embodiment of the present application;

[0046] Figure 5 It is a flow chart of a method for controlling bubble discharge provided in yet another embodiment of the present application. DETAILED DESCRIPTION

[0047] The following is a description of exemplary embodiments of the present application in conjunction with the accompanying drawings, including various details of the embodiments of the present application to facilitate understanding, which should be considered as merely exemplary. Therefore, it should be recognized by those of ordinary skill in the art that various changes and modifications can be made to the embodiments described herein without departing from the scope and spirit of the present application. Similarly, for the sake of clarity and conciseness, the description of well-known functions and structures is omitted in the following description.

[0048] Obviously, the described embodiments are only part of the embodiments of the present application, but not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present application.

[0049] It should be noted that the terminal devices involved in the embodiments of the present application may include but are not limited to mobile phones, personal digital assistants (PDAs), wireless handheld devices, tablet computers and other smart devices; display devices may include but are not limited to personal computers, televisions and other devices with display functions.

[0050] In addition, the term "and / or" in this article is only a description of the association relationship between the associated objects, indicating that there can be three relationships. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. In addition, the character " / " in this article generally indicates that the associated objects before and after are in an "or" relationship.

[0051] Usually, in a ventricular assist system, such as an implantable left ventricular assist device (LVAD), the catheter pump is connected to the perfusion line during operation to prevent blood from entering the catheter pump and causing the pump to stop. The perfusion fluid is used to flush the internal gap of the catheter pump. However, air may enter the perfusion line. Traditional pressure sensors cannot sense smaller bubbles quickly. Therefore, bubble sensors, such as ultrasonic sensors, capacitive sensors, etc., can be used to detect small bubbles in the perfusion line. Bubbles generally pass through the bubble sensor in a very short time, so the corresponding triggered bubble alarm is relatively short and will disappear. However, the bubble may still remain in the flow channel after passing through the bubble sensor. If the bubble alarm disappears, the operator will not be able to know the current bubble situation, which may lead to the risk of bubbles entering the human body and causing safety hazards. Moreover, the solution in the related art stops perfusion immediately after detecting bubbles, and cannot guarantee the stable operation of the perfusion system.

[0052] Therefore, there is an urgent need for an extracorporeal control device that can accurately discharge bubbles in the perfusion pipeline while ensuring the stability of the overall perfusion operation.

[0053] Please refer to Figure 1 , which shows a schematic diagram of the architecture of an in vitro control device provided by an embodiment of the present application. Figure 1As shown, in this embodiment, the extracorporeal control device 100 can be applied to a ventricular assist system, and the extracorporeal control device can include a flow acquisition module 101 and a bubble discharge module 102 .

[0054] The distance acquisition module 101 may be used to acquire the bubble safety distance and the current bubble movement distance in response to detecting bubbles in the perfusion pipeline.

[0055] The bubble discharge module 102 may be used to compare the bubble movement distance with the bubble safety distance, so as to control the discharge of the bubble based on the comparison result.

[0056] It should be noted that the bubble safety distance can be a presumed safety distance where bubble discharge processing is not required, that is, the distance between the position where the bubble is detected and the safety position where bubble discharge processing is not required. The bubble movement distance can be the distance between the position where the bubble is detected and the position where the bubble moves in real time.

[0057] It should be noted that the result of the comparison process may include that the bubble movement distance is greater than or equal to the bubble safety distance, and the bubble movement distance is less than the bubble safety distance.

[0058] In this way, the discharge of bubbles in the perfusion pipeline can be controlled by comparing the size relationship between the bubble movement distance and the bubble movement distance through the extracorporeal control device, which can effectively discharge the bubbles in the perfusion pipeline while ensuring the stability and reliability of the overall perfusion operation.

[0059] Optionally, in a possible implementation of this embodiment, the distance acquisition module 101 can also be used to obtain the current perfusion flow value in response to detecting bubbles in the perfusion pipeline, so as to determine the bubble safety distance based on the current perfusion flow value and using preset safety rules.

[0060] In this implementation, the preset safety rules include a preset constraint relationship between the perfusion flow value and the bubble safety distance, and a preset safety distance value range corresponding to the bubble safety distance. The preset constraint relationship between the perfusion flow value and the bubble safety distance is that the larger the perfusion flow value, the smaller the bubble safety distance.

[0061] It is understandable that, in actual application, the preset security rules may be determined according to the actual application scenario.

[0062] In a specific implementation process of this implementation method, the distance acquisition module 101 can be used to determine the bubble safety distance based on the current perfusion flow value and the preset safety distance value range by utilizing the preset constraint relationship between the perfusion flow value and the bubble safety distance.

[0063] In one case of the specific implementation process, the distance acquisition module 101 can be specifically used to utilize the preset constraint relationship between the perfusion flow value and the bubble safety distance to calculate the bubble safety distance based on the current perfusion flow value, and the bubble safety distance is within the preset safety distance value range.

[0064] Preferably, the preset constraint relationship between the injection flow value and the bubble safety distance can be expressed as formula (1):

[0065] d=f1(Q) (1)

[0066] Among them, d is the bubble safety distance, Q is the perfusion flow value when the bubble is detected, and the value range of d is (0, D), that is, the preset safety distance value range, and D can be a preset value. For example, D can be the distance between the position where the bubble is detected and the position of the catheter pump connector.

[0067] Here, the bubble safety distance may be the distance between the position where the bubble is detected and the position that satisfies the preset constraint relationship. The bubble safety distance should be within the preset safety distance value range.

[0068] In this way, when bubbles are detected in the perfusion pipeline, the bubble safety distance that meets the preset safety rules can be obtained based on the current perfusion flow value and the preset safety rules, thereby improving the accuracy of the bubble safety distance, so as to improve the reliability of subsequent bubble discharge control.

[0069] In another specific implementation process of this implementation, further, the distance acquisition module 101 can also be used to obtain the bubble movement distance based on the radius of the perfusion pipeline and the perfusion flow value using a preset movement distance algorithm.

[0070] In one case of the specific implementation process, the distance acquisition module 101 can also be used to calculate the bubble movement distance corresponding to each preset time interval based on the radius of the perfusion pipeline and the perfusion flow value at the preset time interval, and then the bubble movement distance of each preset time interval can be accumulated and calculated to obtain the current bubble movement distance.

[0071] In this specific implementation process, the radius of the perfusion pipeline can be the radius of the inner wall of the pipeline, that is, the inner diameter of the perfusion pipeline. The perfusion flow value can be a real-time value of the perfusion flow.

[0072] Preferably, the distance acquisition module 101 can be used to acquire the perfusion flow value, and calculate the current bubble movement distance d1 based on the radius of the perfusion pipeline and the perfusion flow value according to the preset time interval using the following formula (2):

[0073]

[0074] Wherein, r is the radius of the perfusion pipeline, Q is the perfusion flow value, and Δt is a preset time interval. Preferably, Δt may be 1 second (s).

[0075] In this way, the bubble movement distance can be obtained through real-time calculation, and the bubble movement position can be detected in real time, so as to accurately control the bubble discharge based on the subsequent comparison results of the bubble movement distance and the bubble safety distance.

[0076] In another specific implementation process of this implementation, the distance acquisition module 101 may include a flow meter. The distance acquisition module 101 may also be used to directly acquire the current perfusion flow value through the flow meter in response to detecting bubbles in the perfusion pipeline.

[0077] In another specific implementation process of this implementation method, the distance acquisition module 101 can also be used to obtain the current motor speed detected by the extracorporeal control device in response to detecting bubbles in the perfusion pipeline, and obtain the current perfusion flow value based on the current motor speed and using the preset correlation between the motor speed and the perfusion flow value.

[0078] In another specific implementation process of this implementation method, the distance acquisition module 101 can also be used to obtain the current perfusion pressure value detected by the extracorporeal control device in response to detecting bubbles in the perfusion pipeline, and obtain the current perfusion flow value based on the current perfusion pressure value and using the preset correlation between the perfusion pressure value and the perfusion flow value.

[0079] In this specific implementation process, the perfusion flow value is inversely proportional to the perfusion pressure value. The extracorporeal control device can be used to detect the perfusion pressure value.

[0080] In another specific implementation process of this implementation method, the distance acquisition module 101 can also be used to obtain the current motor speed and perfusion pressure value detected by the extracorporeal control device in response to detecting bubbles in the perfusion pipeline, and estimate the current perfusion flow value based on the current motor speed and perfusion pressure value using a preset fluid dynamics model.

[0081] It is understandable that, here, other existing methods may also be used to obtain the perfusion flow value corresponding to the moment when the bubble in the perfusion pipeline is detected, and no specific limitation is made here.

[0082] Optionally, in a possible implementation of the present embodiment, the bubble discharge module 102 may also be used to output a prompt message for disconnecting a connector in response to the bubble movement distance being greater than or equal to a bubble safety distance, wherein the connector is disposed between the perfusion pipeline and the catheter pump, and in response to the operator disconnecting the connector, obtain a perfusion pressure value, and in response to the perfusion pressure value being less than a preset pressure threshold, perform pressurization processing to control the discharge of the bubbles.

[0083] In this implementation, the preset pressure threshold may be determined according to the configuration of the actual extracorporeal control device. For example, the preset pressure threshold may be 50 mmHg.

[0084] In a specific implementation process of this implementation method, the bubble discharge module 102 can be specifically used to increase the motor speed in response to the perfusion pressure value being less than a preset pressure threshold, and output a prompt message for connecting the connector in response to the motor speed satisfying a preset termination condition.

[0085] In this implementation, the motor speed may include the speed of a motor of an infusion pump of the extracorporeal control device.

[0086] In one case of the specific implementation process, the bubble discharge module 102 can be used to increase the motor speed of the perfusion pump when the perfusion pressure value is less than a preset pressure threshold, so as to adjust the motor speed to a preset motor speed until a preset termination condition is met, and output a prompt message for connecting the connector.

[0087] In this implementation, the preset termination condition may include the motor running a preset number of revolutions at a preset motor speed.

[0088] Exemplarily, the preset motor speed may be n1, for example, the value range of n1 may be 0.1 revolutions per second (r / s) < n1 < 1 r / s. The preset number of revolutions may be N, for example, N may be 2 revolutions. Here, the motor speed of the perfusion pump motor may be adjusted to n1, and when the perfusion pump motor rotates N revolutions at the speed n1, a prompt message of the connection operation is output to remind the operator to perform the connection operation.

[0089] In this way, when the bubble movement distance is greater than or equal to the bubble safety distance, a prompt message for disconnecting the connector can be output, and the perfusion pressure value can be obtained based on the instruction received based on the operator's operation to disconnect the connector. When the perfusion pressure value is less than a preset pressure threshold, pressurization processing is performed to control the discharge of the bubbles, which can further improve the reliability of bubble discharge control.

[0090] Optionally, in a possible implementation of the present embodiment, the bubble discharge module 102 can be specifically used to output a prompt message for disconnecting the connector in response to the bubble movement distance being greater than or equal to the bubble safety distance, obtain the perfusion pressure value in response to the operator not performing the operation of disconnecting the connector, and shut down the motor and output an alarm message in response to the perfusion pressure value being greater than a preset pressure threshold and the bubble movement distance reaching a preset distance threshold.

[0091] In this implementation, the preset distance threshold may be determined based on the distance between the position where the bubble is detected and the position of the catheter pump connector. For example, D is the distance between the position where the bubble is detected and the position of the catheter pump connector, and the preset distance threshold may be 0.9D.

[0092] Optionally, in a possible implementation of this embodiment, the bubble discharge module 102 may also be used to maintain the motor speed in response to the bubble movement distance being less than the bubble safety distance.

[0093] In this way, when the bubble movement distance is less than the bubble safety distance, the current perfusion flow rate is maintained unchanged, thereby ensuring the stability of the perfusion to the greatest extent.

[0094] Optionally, in a possible implementation of this embodiment, the extracorporeal control device 100 may further include an information display module, wherein the information display module may be used to display prompt information and a processing progress indicator.

[0095] In this implementation, the information display module may include a controllable display screen of the extracorporeal control device.

[0096] Optionally, in a possible implementation of this embodiment, the in vitro control device may further include a bubble detection module, a pressure detection module, and a motor speed adjustment module, wherein the bubble detection module may be used to detect bubbles in the perfusion pipeline. The pressure detection module may be used to detect the perfusion pressure value. The motor speed adjustment module may be used to adjust the motor speed based on the detection result of the perfusion pressure value.

[0097] In this implementation, the bubble detection module may include a bubble sensor. The pressure detection module may include a pressure sensor.

[0098] Figure 2 is a schematic diagram of the structure of a ventricular assist system provided by another embodiment of the present application. In order to better understand the system of the embodiment of the present application, the following is a schematic diagram of the structure of a ventricular assist system provided by another embodiment of the present application. Figure 2 To Attachment Figure 4 The system of the embodiment of the present application is described with reference to specific application scenarios.

[0099] like Figure 2 As shown, in the embodiment of the present application, the ventricular assist system 200 may include an extracorporeal control device 1, a catheter pump 2, a perfusion pump 13, and a perfusion circuit 14.

[0100] The catheter pump 2 can be used to assist in pumping blood. The catheter pump 2 is connected to the perfusion pipeline 14 via a connector 21 .

[0101] The perfusion pump 13 can be used to pump the perfusion fluid to the catheter pump 2 through the perfusion pipeline 14 .

[0102] The perfusion line 14 is disconnected and connected to the catheter pump 2 via a connector 21 .

[0103] The extracorporeal control device 1 may include a distance acquisition module and a bubble discharge module. The distance acquisition module is used to acquire a bubble safety distance and a current bubble movement distance in response to detecting bubbles in the perfusion line. The bubble discharge module is used to compare the bubble movement distance with the bubble safety distance, so as to control the discharge of the bubbles based on the comparison result.

[0104] Optionally, in a possible implementation of this embodiment, the connector 21 may be a Luer connector.

[0105] Optionally, in a possible implementation of this embodiment, as Figure 2 As shown, the extracorporeal control device 1 may further include a bubble sensor 11 and a pressure sensor 12 .

[0106] Figure 3 is a schematic diagram of the structure of a bubble sensor in an in vitro control device provided by another embodiment of the present application, Figure 4 It is a side view of a bubble sensor in an extracorporeal control device provided in another embodiment of the present application.

[0107] Preferably, if Figure 3 and Figure 4 As shown, the bubble sensor may include an upper housing 110 and a lower housing 111. The distance H between the upper housing 110 and the lower housing 111 should be slightly smaller than the outer diameter of the perfusion pipeline 14, and preferably, H may be 2 millimeters (mm). In this way, the detection accuracy of the bubble sensor can be ensured and the pipeline can be prevented from loosening.

[0108] Preferably, if Figure 4 As shown, the perfusion line 14 contains perfusion liquid 31 and air bubbles 4 .

[0109] Preferably, if Figure 2 As shown, the bubble sensor 11 can be installed behind the pressure sensor 12 to facilitate detecting the bubble discharge time.

[0110] Preferably, if Figures 2 to 4 As shown, in the ventricular assist system 200, the catheter pump 2 is connected to the perfusion line 14, which can prevent blood from entering the catheter pump 2. The extracorporeal control device 1 can also pump the perfusion liquid 31 in the infusion bag 3 to the distal end of the catheter pump 2 through the perfusion pump 13 to flush the internal gap of the catheter pump 2. During the operation of the ventricular assist system 200, the perfusion line 14 may be filled with air due to line leakage, and the extracorporeal control device 1 can integrate a bubble sensor 11. When there is only perfusion liquid in the perfusion line 14, the flow of the liquid is not affected in any way. At this time, the signal received by the bubble sensor 11 remains unchanged. When the perfusion liquid 31 in the infusion bag 3 is less or the perfusion line 14 is disconnected, causing air to enter the line, the signal received by the sensor changes due to the different parameters such as the acoustic impedance or dielectric parameters of the gas and liquid themselves, thereby detecting the presence of the bubble 4.

[0111] Optionally, in a possible implementation of this embodiment, the distance acquisition module of the extracorporeal control device 1 can also be used to utilize the preset constraint relationship between the perfusion flow value and the bubble safety distance to determine the bubble safety distance based on the current perfusion flow value and the preset safety distance value range.

[0112] In this embodiment, the preset constraint relationship between the perfusion flow rate value and the bubble safety distance may be that the larger the perfusion flow rate value is, the smaller the bubble safety distance is.

[0113] Here, the perfusion pressure value and the perfusion flow value are inversely proportional, and the perfusion pressure value P can be measured by the pressure sensor 12 of the in vitro control device 1. To ensure that the bubbles can be discharged in time, the larger the perfusion flow value, the smaller the bubble safety distance. The value range of the bubble safety distance d can be (0, D), and the preset safety distance value range can be (0, D), where D is the distance from the bubble sensor 11 to the connection point of the Luer connector 21 of the catheter pump 2.

[0114] It is understandable that the setting of the bubble safety distance can extend the perfusion time to a certain extent. When the bubble sensor detects bubbles, the bubbles will not immediately enter the pipeline behind the Luer connector 21. The perfusion will not be stopped immediately when the bubbles are detected, which can extend the perfusion time. Correspondingly, it takes a certain time t0 from the issuance of the bubble discharge prompt information to the operator disconnecting the Luer connector 21. Therefore, when determining the specific value of the bubble safety distance, it is also necessary to leave a margin time for the exhaust operation to ensure that D minus d is greater than or equal to the distance of the bubble movement within t0, so as to prevent the bubbles from entering the pipeline behind the Luer connector 21 before the Luer connector 221 is disconnected.

[0115] Exemplarily, D may be 2 meters (m) to 3 meters. If the perfusion flow rate is 30 milliliters per hour (ml / h), d may be any value between 1.2 meters and 1.8 meters.

[0116] Optionally, in a possible implementation of the present embodiment, the bubble discharge module of the extracorporeal control device 1 can also be used to output a prompt message for disconnecting the connector in response to the bubble movement distance being greater than or equal to the bubble safety distance, the connector being arranged between the perfusion pipeline and the catheter pump, obtaining the perfusion pressure value in response to the operator disconnecting the connector, and performing pressurization processing in response to the perfusion pressure value being less than a preset pressure threshold to control the discharge of the bubbles.

[0117] Alternatively, it can be used to maintain the motor speed in response to the bubble movement distance being less than the bubble safety distance.

[0118] Alternatively, it can be used to output a prompt message for disconnecting the connector in response to the bubble movement distance being greater than or equal to the bubble safety distance, obtain the perfusion pressure value in response to the operator not performing the operation of disconnecting the connector, and shut down the motor and output an alarm message in response to the perfusion pressure value being greater than a preset pressure threshold and the bubble movement distance reaching a preset distance threshold.

[0119] Exemplarily, the bubble movement distance may be d1, and the bubble safety distance may be d. When d1<d, the current perfusion flow value may be kept unchanged, that is, the current rotation speed of the perfusion pump motor may be kept unchanged. When d1≥d, the in vitro control device 1 may output information prompting to disconnect the Luer connector 21 to control the discharge of bubbles. When the Luer connector 21 connection of the catheter pump 2 is disconnected, the perfusion pressure value P drops rapidly, and the real-time perfusion pressure value may be detected by the pressure sensor 12. When the perfusion pressure value P≤50 mmHg (mmHg), the in vitro control device 1 sends pressurization control information to the perfusion pump motor to increase the motor speed n1 of the perfusion pump motor, for example, 0.1r / s<n1<1r / s, to increase the perfusion flow value and control the rapid discharge of bubbles. When the perfusion pump motor has completed N revolutions at the motor speed n1, the extracorporeal control device 1 controls the bubbles to be discharged, and can output a prompt message to prompt the operator to quickly connect the Luer connector, and adjust the motor speed of the perfusion pump motor so that the perfusion motor can perform perfusion at a normal perfusion flow value, such as 30 ml / h.

[0120] It is understandable that here, the setting of the preset number of turns N is mainly considered to ensure that exhaust is completed within this operating time. Preferably, N can be 2 turns. Since the extracorporeal control device 1 issues a pressurization command when exhausting, the pressure in the perfusion circuit can be maintained at a certain level. For example, the perfusion pressure value in the perfusion circuit can be greater than 300 mmHg, and after connecting the Luer connector 21, it can quickly return to the normal perfusion flow rate of 30 ml / h to flush the inside of the catheter pump 2.

[0121] Exemplarily, if the operator does not disconnect the Luer connector 21 and the extracorporeal control device 1 detects that the perfusion pressure value P>50mmHg, d1=0.9D, the extracorporeal control device 1 can stop the operation of the perfusion pump motor and display a high-level alarm for air entering the perfusion line.

[0122] In this way, using the ventricular assist system in this embodiment, a bubble sensor can be integrated on the extracorporeal control device in the ventricular assist system. When air enters the perfusion pipeline, the extracorporeal control device judges and processes the bubble safety distance and bubble movement distance that are obtained as a benchmark to ensure that the bubbles can be discharged in time. When the bubble movement distance is less than the bubble safety distance, the current perfusion flow rate is maintained unchanged. As the bubbles continue to move forward, when the bubble movement distance reaches the bubble safety distance, the extracorporeal control device can prompt the operator to disconnect the Luer connector and increase the perfusion flow rate to allow the bubbles to be quickly discharged from the perfusion pipeline, thereby ensuring the accuracy of exhaust.

[0123] In addition, with the ventricular assist system in this embodiment, when the bubble movement distance is less than the bubble safety distance, the current perfusion flow rate is maintained unchanged, which can maximize the stability of perfusion.

[0124] Figure 5 FIG. 1 is a flow chart of a method for controlling bubble discharge provided by another embodiment of the present application. Figure 5 In this embodiment, the bubble discharge control method can be applied to the in vitro control device as described in the above embodiments, and the bubble discharge control method may include:

[0125] Step 501: In response to detecting bubbles in the perfusion pipeline, obtain a bubble safety distance and a current bubble movement distance.

[0126] Step 502: Compare and process the bubble movement distance and the bubble safety distance, and control the discharge of the bubble based on the comparison result.

[0127] In this way, in response to detecting bubbles in the perfusion pipeline, the bubble safety distance and the current bubble movement distance can be obtained, and then the bubble movement distance and the bubble safety distance can be compared and processed to control the discharge of the bubbles based on the comparison result. Since the discharge of bubbles in the perfusion pipeline can be controlled by comparing the size relationship between the bubble movement distance and the bubble movement distance, the bubbles in the perfusion pipeline can be effectively discharged while ensuring the stability and reliability of the overall perfusion operation.

[0128] Optionally, in a possible implementation of this embodiment, in step 501, first, in response to detecting bubbles in the perfusion pipeline, a current perfusion flow value may be acquired. Secondly, based on the current perfusion flow value, the bubble safety distance may be determined using a preset safety rule.

[0129] In this implementation, the preset safety rules include a preset constraint relationship between the perfusion flow value and the bubble safety distance, and a preset safety distance value range corresponding to the bubble safety distance. The preset constraint relationship between the perfusion flow value and the bubble safety distance is that the larger the perfusion flow value, the smaller the bubble safety distance.

[0130] In a specific implementation process of this implementation mode, the bubble safety distance is determined based on the current perfusion flow value and the preset safety distance value range by utilizing the preset constraint relationship between the perfusion flow value and the bubble safety distance.

[0131] In one case of the specific implementation process, the preset constraint relationship between the perfusion flow value and the bubble safety distance can be used to calculate the bubble safety distance based on the current perfusion flow value, and the bubble safety distance is within the preset safety distance value range.

[0132] It is understandable that, here, the bubble safety distance can be the distance between the position where the bubble is detected and the position that satisfies the preset constraint relationship. The bubble safety distance should be within the preset safety distance value range. The position where the bubble is detected can be the position of the bubble sensor.

[0133] In another specific implementation process of this implementation, based on the radius of the perfusion pipeline and the perfusion flow value, a preset movement distance algorithm is used to obtain the bubble movement distance.

[0134] In one specific implementation process, first, the bubble movement distance corresponding to each preset time interval can be calculated based on the radius of the perfusion pipeline and the perfusion flow value according to the preset time interval. Secondly, the bubble movement distance of each preset time interval can be accumulated and calculated to obtain the final bubble movement distance.

[0135] Optionally, in a possible implementation of the present embodiment, in step 502, in response to the bubble movement distance being greater than or equal to the bubble safety distance, a prompt message for disconnecting the connector can be output, and the connector is arranged between the perfusion pipeline and the catheter pump, so that the perfusion pressure value can be obtained, and in response to the perfusion pressure value being less than a preset pressure threshold, pressurization processing is performed to control the discharge of the bubbles.

[0136] In a specific implementation process of this implementation mode, the motor speed may be increased in response to the injection pressure value being less than a preset pressure threshold. In response to the preset termination condition being met, a prompt message for the connection operation is output.

[0137] One situation of the specific implementation process is that when the perfusion pressure value is less than a preset pressure threshold, the motor speed of the perfusion pump is increased to adjust the motor speed to a preset speed until the preset termination condition is met, and a prompt message for connecting the connector operation is output.

[0138] In this implementation, the preset termination condition may include the motor running a preset number of revolutions at a preset motor speed.

[0139] It should be noted that the specific implementation process provided in this implementation can be combined with the various specific implementation processes provided in the aforementioned implementation to implement the bubble discharge control method of this embodiment. For detailed description, please refer to the relevant content in the aforementioned implementation, which will not be repeated here.

[0140] Optionally, in a possible implementation of this embodiment, in step 502, in response to the bubble movement distance being less than the bubble safety distance, the motor speed may be maintained.

[0141] Optionally, in a possible implementation of the present embodiment, in step 502, in response to the bubble movement distance being greater than or equal to the bubble safety distance, a prompt message for disconnecting the connector can be output; in response to the operator not performing the operation of disconnecting the connector, the perfusion pressure value can be obtained; in response to the perfusion pressure value being greater than a preset pressure threshold and the bubble movement distance reaching a preset distance threshold, the motor can be shut down and an alarm message can be output.

[0142] It should be noted that the specific implementation process provided in this implementation can be combined with the various specific implementation processes provided in the aforementioned implementation to implement the bubble discharge control method of this embodiment. For detailed description, please refer to the relevant content in the aforementioned implementation, which will not be repeated here.

[0143] It should be noted that, for the above-mentioned embodiments, for the sake of simplicity, they are all expressed as a series of action combinations, but those skilled in the art should be aware that the present application is not limited by the described order of actions, because according to the present application, certain steps can be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in the specification are all preferred embodiments, and the actions and modules involved are not necessarily required by the present application.

[0144] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0145] In the technical solution of this application, the user personal information involved, such as the collection, storage, use, processing, transmission, provision and disclosure of user images and attribute data, etc., complies with the provisions of relevant laws and regulations and does not violate public order and good morals.

[0146] A person skilled in the art will understand that all or part of the steps to implement the above embodiments may be accomplished by hardware or by instructing related hardware through a program, and the program may be stored in a computer-readable storage medium, and the above-mentioned storage medium may be a read-only memory, a disk or an optical disk, etc.

[0147] It should be understood that the various forms of processes shown above can be used to reorder, add or delete steps. For example, the steps recorded in this disclosure can be executed in parallel, sequentially or in different orders, as long as the desired results of the technical solution disclosed in this application can be achieved, and this document is not limited here.

[0148] The above specific implementations do not constitute a limitation on the protection scope of this application. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions and improvements made within the spirit and principles of this application should be included in the protection scope of this application.

Claims

1. An extracorporeal control device, characterized in that: Applied to a ventricular assist system, the external control device comprises: a distance acquisition module, for acquiring a bubble safety distance and a current bubble movement distance in response to detecting bubbles in the perfusion pipeline; The bubble discharge module is used to compare the bubble movement distance and the bubble safety distance, so as to control the discharge of the bubble based on the comparison result.

2. The device according to claim 1, characterized in that The distance acquisition module is also used to obtain the current perfusion flow value in response to detecting bubbles in the perfusion pipeline, so as to determine the bubble safety distance based on the current perfusion flow value and using a preset safety rule; wherein, The preset safety rules include a preset constraint relationship between the perfusion flow value and the bubble safety distance, and a preset safety distance value range corresponding to the bubble safety distance. The preset constraint relationship between the perfusion flow value and the bubble safety distance is that the larger the perfusion flow value, the smaller the bubble safety distance.

3. The device according to claim 2, characterized in that The distance acquisition module is specifically used to determine the bubble safety distance based on the current perfusion flow value and the preset safety distance value range by utilizing the preset constraint relationship between the perfusion flow value and the bubble safety distance.

4. The device according to claim 2, characterized in that The distance acquisition module is further used to obtain the bubble movement distance based on the radius of the perfusion pipeline and the perfusion flow value using a preset movement distance algorithm.

5. The device according to claim 4, characterized in that The distance acquisition module is specifically used to calculate the bubble movement distance corresponding to each preset time interval based on the radius of the perfusion pipeline and the perfusion flow value according to the preset time interval; The bubble movement distance at each preset time interval is cumulatively calculated to obtain the current bubble movement distance.

6. The device according to claim 1, characterized in that The bubble discharge module is further used to output a prompt message for disconnecting a connector in response to the bubble movement distance being greater than or equal to the bubble safety distance, wherein the connector is provided between the perfusion pipeline and the catheter pump; Get the perfusion pressure value; In response to the infusion pressure value being less than a preset pressure threshold, a pressurization process is performed to control the discharge of the bubbles.

7. The device according to claim 6, characterized in that The bubble discharge module is further configured to increase the motor speed in response to the injection pressure value being less than a preset pressure threshold; In response to the preset termination condition being met, a prompt message for completing the connection operation is output.

8. The device according to claim 1, characterized in that The bubble discharge module is used to maintain the motor speed in response to the bubble movement distance being less than the bubble safety distance.

9. The device according to claim 1, characterized in that The in vitro control device also includes an information display module; The information display module is used to display prompt information and processing progress indicators.

10. The device according to claim 1, characterized in that The in vitro control device also includes a bubble detection module, a pressure detection module, and a motor speed adjustment module; The bubble detection module is used to detect bubbles in the perfusion pipeline; The pressure detection module is used to detect the perfusion pressure value; The motor speed adjustment module is used to adjust the motor speed based on the detection result of the perfusion pressure value.

11. A ventricular assist system, characterized in that: The ventricular assist system comprises a catheter pump, a perfusion pump, a perfusion circuit and an extracorporeal control device according to any one of claims 1-10; The catheter pump is used to assist in pumping blood; The perfusion pump is used to pump the perfusion fluid to the catheter pump through the perfusion pipeline; The perfusion pipeline is disconnected and connected with the catheter pump through a joint.

12. A method for controlling bubble discharge, characterized in that: The method is applied to the extracorporeal control device according to any one of claims 1 to 10, and the method comprises: In response to detecting bubbles in the perfusion line, obtaining a bubble safety distance and a current bubble movement distance; The bubble movement distance and the bubble safety distance are compared and processed to control the discharge of the bubble based on the comparison result.

13. A non-transitory computer-readable storage medium storing computer instructions, characterized in that: The computer instructions are used to cause the computer to execute the method according to claim 12.

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