Cleaning agent box

Abstract

Presented herein are cleaning agent cartridges for storing and transporting cleaning agents, techniques for mixing the cleaning agent with a fluid within a cleaning agent cartridge, and techniques for dispensing the resulting fluid cleaning composition from the cleaning agent cartridge.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to Australian patent application No. 2022902786, filed on September 26, 2022, entitled “DRY POWDER CARTRIDGE”, the contents of which are hereby incorporated herein by reference. Technical Field

[0003] The present invention generally relates to cartridges for storing and transporting cleaning agents, mixing the cleaning agents with fluids, and dispensing the resulting fluid cleaning compositions. Background Art

[0004] There are many devices / systems that include internal passages / lumens that require regular or routine cleaning. For example, there are different types of medical devices (medical instruments) that can be used to perform diagnostic and / or surgical procedures. An endoscope is one such medical device that can be used to visually inspect a hollow organ or body cavity. Specially designed endoscopes are used for different examinations, such as bronchoscopy, cystoscopy, gastroscopy, and proctoscopy. Endoscopes, as well as other available diagnostic and / or surgical medical devices, can be reused on multiple patients and include one or more internal lumens that must be cleaned between uses. Summary of the invention

[0005] In one aspect, a detergent cartridge is provided. The detergent cartridge comprises: a tank configured to store dry powder; a closure assembly configured to be attached to the tank to form a closed volume; at least one first port disposed in the closure assembly, the at least one first port configured for fluid to enter the tank; a riser extending from the at least one first port into the tank; and one or more second ports disposed in the closure assembly, the one or more second ports configured for fluid to enter the tank and fluid to leave the tank.

[0006] In another aspect, a method is provided. The method comprises: fluidly coupling at least one first port and one or more second ports of a cartridge to a cleaning device, wherein the cartridge forms a closed container comprising at least one powder; introducing a fluid into the cartridge through the at least one first port; introducing a fluid into the cartridge through the one or more second ports, wherein the fluid and the powder form a fluid cleaning composition; and dispensing the fluid cleaning composition from the cartridge through at least one of the one or more second ports.

[0007] In another aspect, a method is provided. The method comprises: fluidly coupling a cartridge to a cleaning device, wherein the cartridge forms a closed container comprising at least one powder; introducing a fluid from a first hydration site within the cartridge; introducing a fluid from a second hydration site within the cartridge, wherein the fluid and the at least one powder form a fluid cleaning composition within the cartridge; and dispensing the fluid cleaning composition from the cartridge.

[0008] On the other hand, a box for storing a dry powder, for hydrating the dry powder to provide a slurry, and for dispensing the slurry; the box comprises: a closure assembly and a can, the can being closed by the closure assembly, the closure assembly comprising at least one first port and one or more second ports, the at least one first port being operable to allow fluid to enter the can or gas to flow out of the can, the one or more second ports being operable to allow fluid to enter the can and slurry from the can to pass through, wherein the can is suitable for holding the dry powder, wherein a conduit extends from the first port in the can to define a first hydration site, and the one or more second ports define a second hydration site. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Embodiments of the present invention are described herein with reference to the accompanying drawings, in which:

[0010] Figure 1 is a schematic diagram illustrating an endoscope having an internal lumen that can be cleaned in conjunction with a cleaning agent cartridge according to certain embodiments presented herein.

[0011] Figure 2A is a flow chart of an example method for cleaning an interior lumen of a medical device using a fluid cleaning composition dispensed from a cleaning agent cartridge according to certain embodiments presented herein.

[0012] Figure 2B is a schematic diagram illustrating the first stage / phase of a process for cleaning a lumen with a fluid cleaning composition.

[0013] Figure 2C is a schematic diagram illustrating the second stage / phase of a process for cleaning a lumen with a fluid cleaning composition.

[0014] Figure 3 is a schematic diagram illustrating the use of a cleaning agent cartridge having a lumen cleaning device according to certain embodiments presented herein.

[0015] Figure 4 is a cross-sectional view of a detergent cartridge according to certain embodiments presented herein.

[0016] Figure 5is a diagram showing a mobile cover according to some embodiments proposed herein Figure 4 A cross-sectional view of a detergent cartridge.

[0017] Figure 6 is a cross-sectional view of another detergent cartridge according to certain embodiments presented herein.

[0018] Fig. 7A , 7B 7C and 7D are a series of schematic diagrams illustrating the operation of a cleaning agent cartridge having a lumen cleaning device for mixing and dispensing a hydrated solid powder (fluid cleaning composition) according to certain embodiments presented herein.

[0019] Fig. 8A , 8B , 8C, 8D, 8E, and 8F are a series of schematic diagrams illustrating the operation of another cleaning agent cartridge for mixing and dispensing hydrated solid powders (fluid cleaning compositions) according to certain embodiments presented herein.

[0020] Fig. 9 is a block diagram illustrating an example computing device configured to operate as a control system for hydration of a powder and dispensing of the resulting fluid cleaning composition, according to certain embodiments presented herein.

[0021] Fig.10 is a flow chart illustrating an example method according to certain embodiments presented herein.

[0022] Fig.11 is a flow chart illustrating another example method according to certain embodiments presented herein. DETAILED DESCRIPTION

[0023] The present invention proposes a detergent box for storing and transporting detergents (e.g., dry powder, fluid, etc.), a technology for mixing the detergent with a fluid in the detergent box, and a technology for distributing the resulting fluid cleaning composition from the detergent box. Fluid cleaning compositions can be used for, for example, the internal passages / lumens of a cleaning system / device. It should be understood that detergent boxes and related technologies can be used with any of many different systems / devices, such as medical devices with internal passages / lumens, food / beverage service lines, etc. However, only for ease of explanation, the technology will be described mainly about the cleaning of the endoscope lumen.

[0024] An endoscope is an elongated tubular medical device that can be rigid or flexible and incorporates an optical or video system and a light source. Typically, an endoscope is configured so that one end can be inserted into a patient's body through a surgical incision or through one of the body's natural openings. Thus, an external observer can see internal structures near the insertion end of the endoscope.

[0025] Endoscopes are used not only for research, but also to perform diagnostic and surgical procedures. For example, endoscopy is used worldwide for screening, diagnosis, and treatment of gastrointestinal (GI) diseases, among other things, and enables early detection and treatment. Endoscopic procedures are becoming increasingly popular because they are minimally invasive in nature and provide better patient outcomes (by reducing healing time and exposure to infection), allowing hospitals and clinics to achieve higher patient turnover rates.

[0026] Figure 1 1 is a schematic diagram of an example endoscope 100 with which aspects of the technology presented herein may be implemented. As shown, similar to most endoscopes, the endoscope 100 has a long tubular structure having a distal end / tip 102 at one end for insertion into a patient and an opposing proximal or connector end 104, with a control handle 106 located between the two ends (e.g., typically at the center of the length between the connector end 104 and the distal end 102). The connector end 104 includes a plurality of connectors that enable the endoscope to be attached to, for example, a light source 108, a water source 110, a suction source ( Figure 1 ) and a pressurized air source 112. For example, Figure 1 Shown in A are aspiration port / connector 137, water jet (auxiliary) port / connector 139, water port / connector 141, and air port / connector 143. During the process of controlling the endoscope 100 through the valves, which in this example include the aspiration valve 114, the air / water valve 116, and the biopsy valve 118, and the control wheel 120, the operator holds the control handle 106.

[0027] like Figure 1 As shown, endoscope 100 includes internal channels for delivering air and / or water, providing suction, or allowing access to forceps and other medical equipment required during surgery. Thus, distal tip 102 contains a camera lens ( Figure 1 The inner passages are shown in Figure 100 and have outlets for lighting, air and water, and outlets for suction and forceps. Some of the inner passages extend from one end of the endoscope 100 to the other, while others extend through a valve seat at the control handle. Some passages fork, while others merge from two passages into one.

[0028] More specifically, Figure 1Shown in the figure are a biopsy / aspiration channel 122, an air channel 124, a water channel 126, and a water jet channel 128. The biopsy / aspiration channel 122 includes two sections, referred to as a proximal section 122A and a distal section 122B, which are connected by a suction valve 114. The air channel 124 also includes two sections, referred to as a proximal section 124A and a distal section 124B, which are connected by an air / water valve 116. Similarly, the water channel 126 also includes two sections, referred to as a proximal section 126A and a distal section 126B, which are connected by an air / water valve 116. The distal section 126B of the water channel is connected to the distal section 124B of the air channel at a location 130 within the distal end 102. The water jet channel 128 extends directly from the connector end 104 to the distal end 102 (through the control handle 106), but is similarly referred to as having a proximal section 128A and a distal section 128B. The proximal sections 122A, 124A, 126A, and 128A of the channel are sometimes referred to as being located within the universal soft wire section (soft wire) 132 of the endoscope 100, while the distal sections 122B, 124B, 126B, and 128B of the channel are sometimes referred to as being located within the insertion tube 134 of the endoscope. More generally, as used herein, the proximal sections 122A, 124A, 126A, and 128A are the portions of the channel located between the connector end 104 and the control handle 106 and / or a valve (e.g., valve 114 or 116) at the midpoint of the control handle 106, as the case may be. The distal sections 122B, 124B, 126B, and 128B are portions of the channel between the control handle 106 and / or a valve (eg, valve 114 or 116 ) at a midpoint of the control handle 106 and the distal end 102 of the endoscope 102 .

[0029] The high cost of endoscopes means that they must be reused. Therefore, each endoscope must be thoroughly cleaned and disinfected or sterilized after each use due to the need to avoid cross-contamination between uses. This involves not only the cleaning of the exterior of the endoscope 100, but also the cleaning of the internal channels / lumens (e.g., Figure 1 Cleaning and disinfection of the lumens 122, 124, 126 and 128).

[0030] Endoscopes used for colonoscopy procedures are typically 2.5 meters to 4 meters long and have one or more lumen channels that are no more than a few millimeters in diameter. Ensuring that such long, narrow channels are properly cleaned and disinfected between patients presents considerable challenges. Cleaning is also made more difficult by the fact that there is not just one configuration / type of endoscope. In fact, there are a variety of endoscopic devices, each suited to a specific insertion application, such as a colonoscope inserted into the colon, a bronchoscope inserted into the airway, a gastroscope for examining the stomach, etc. For example, a gastroscope has a smaller diameter than a colonoscope; a bronchoscope is again smaller and shorter in length, while a duodenoscope has a different tip design to access the bile duct.

[0031] A variety of options are available for mechanically removing biological residues from the lumen, which is the first stage of the cleaning and disinfection process. By far the most common procedure for cleaning the lumen is the use of a small brush mounted on a thin, flexible line. In some countries, brushing is a mandatory technique for cleaning the lumen. These brushes are fed into the lumen while the endoscope is immersed in warm water and a cleaning solution. The brush is then pushed / pulled through the length of the lumen in an effort to scrub away the dirt / bioburden. Manual back-and-forth scrubbing is usually required. Water and cleaning solution are then flushed down the lumen. These flush-brush processes are repeated three times or until the endoscope reprocessing technician is satisfied that the lumen is clean. At the end of this cleaning process, air is pumped out of the lumen to dry the lumen. A flexible pull-through device with a wiper can also be used to physically remove material. A stream of liquid through the lumen under limited pressure can also be used.

[0032] However, in general, only larger aspiration / biopsy lumens (e.g. Figure 1 122) can be cleaned by brushing or pulling through. The air / water channels (e.g., channels 124 and 126) may be too small for a brush, so these lumens are usually flushed with water and cleaning solution only.

[0033] After mechanical cleaning, chemical cleaning can be performed to remove residual biological contaminants. Because endoscopes are sensitive and expensive medical devices, biological residues cannot be treated at high temperatures or with strong chemicals. For this reason, mechanical cleaning needs to be as thorough as possible. In many cases, current mechanical cleaning methods cannot completely remove biofilm from the lumen, especially when cleaning relies solely on liquid flow. No matter how good the conventional cleaning process is, it is almost inevitable that a small amount of microbial load will remain in the channel.

[0034] There is significant research that shows that brush cleaning methods, even when performed as specified, do not completely remove biofilm from the lumen of endoscopes. In addition to lack of efficacy, current manual brushing procedures have other disadvantages. The large number of different endoscope manufacturers and models leads to many minor variations in manual cleaning procedures. This leads to confusion and ultimately poor compliance in the cleaning process. Current brushing systems are also dangerous because the chemicals currently used to clean endoscopes can have adverse effects on reprocessors.

[0035] Current manual scrubbing systems are also labor-intensive, resulting in increased costs. Therefore, current methods for cleaning and disinfecting the lumens in medical cleaning equipment are still inadequate, and residual microorganisms are now considered to be a significant threat to patients and staff exposed to these devices. For example, there is evidence that insufficient cleaning and disinfection of the internal structure of endoscopes has led to bacterial transmission between patients, which in turn has led to fatal infections in patients. Between 2010 and 2015, more than 41 hospitals worldwide (mostly in the United States) reported endoscope-related bacterial infections, affecting 300 to 350 patients (http: / / www.modernhealthcare.com / article / 20167415 / NEWS / 167419935). It can be expected that the reduction of bioburden in various medical devices will lead to an overall reduction in infection rates and mortality rates.

[0036] Additionally, if the endoscope is not properly cleaned and dried, biofilms may accumulate on the lumen walls. Biofilms begin to form when free-floating microorganisms attach themselves to a surface and surround themselves with a protective polysaccharide layer. The microorganisms then multiply, or begin to form aggregates with other microorganisms, increasing the extent of the polysaccharide layer. Multiple attachment sites may combine in time to form a large biofilm deposit. Once bacteria or other microorganisms are bound in a biofilm, they become significantly more resistant to chemical and mechanical cleaning than when they are in a free-floating state. The organisms themselves are not inherently more resistant, but rather, resistance is imparted by the polysaccharide film and the fact that the microorganisms can be deeply embedded in the film and isolated from any chemical interaction. Any residual biofilm remaining after an attempted cleaning quickly returns to a state of equilibrium, and the microorganisms continue to grow further within the film. Endoscope lumens are particularly prone to biofilm formation. They are exposed to significant amounts of bioburden, and subsequent cleaning of narrow, long lumens is very difficult due to the difficulty in access and the inability to monitor the cleaning process.

[0037] There is a great deal of pressure in medical facilities to reprocess endoscopes as quickly as possible. Because endoscopes are cleaned by hand, the technician's training and attitude are very important in determining the cleanliness of the device. Residual biofilm on the instrument can cause the patient to acquire an endoscope-acquired infection. Typically, these infections occur in the form of outbreaks and can have fatal consequences for the patient.

[0038] Although as described above, manual cleaning procedures have been used for many years, only recently have systems and methods been provided to overcome or improve at least one shortcoming of the prior art, or at least to provide a useful alternative. Specifically, it has been found that the use of certain fluid cleaning compositions to advance through the corresponding lumen of a medical device is particularly effective in safely removing unwanted substances through physical interactions with the lumen. In some such technologies, a fluid cleaning composition in the form of a "slurry" is produced, which is distributed into a suitable amount, and then delivered at least a portion of the lumen at a suitable speed. In one form, the distribution amount of the slurry is sometimes referred to as 'cleaning liquid mass' or 'liquid mass' in this article.

[0039] As used herein, the term "fluid cleaning composition" refers to a fluid solution that can remove (e.g., physically separate, dissolve, etc.) contaminants. The fluid cleaning composition can be a saturated or unsaturated solution; and the fluid cleaning composition can include solid particles in some cases, for example, when a dry powder cleaner is present in a solvent above the corresponding saturation limit. As used herein, the term "slurry" refers to a fluid solution (e.g., a specific fluid cleaning composition) that includes solid (e.g., powder) particles suspended in a fluid.

[0040] Figure 2A An exemplary method 240 of cleaning a lumen of a medical device using a fluid cleaning composition in the form of a slurry and a cleaning bolus is presented. Figure 2A The method 240 begins at 242 by generating, mixing or otherwise obtaining a slurry. At 244, the slurry is dispensed into suitable amounts. At 246, the dispensed amount of slurry (i.e., a cleaning bolus) is delivered (e.g., pushed) through at least a portion of the lumen to be cleaned. This process can of course be implemented in any of a variety of ways.

[0041] For example, any suitable slurry can be implemented. In one example, the slurry has a liquid component and a powder component. The liquid component of the slurry can promote the fluidity of the composition, and the presence of the powder can be used to interact with the wall of the target lumen (e.g., channel) to thereby clean the lumen. According to some examples, the amount of the powder component of the slurry in the corresponding liquid is greater than the corresponding saturation limit, which can promote the cleaning interaction between the mixture and the wall of the lumen. In certain embodiments, the slurry comprises a mixture of sodium bicarbonate powder and water, wherein sodium bicarbonate is present in an amount greater than the corresponding saturation level. For example, in many embodiments, sodium bicarbonate can be present in an amount greater than 10% by mass of the mixture at some stages. It has been determined that a mixture of sodium bicarbonate and water can be particularly effective in the disclosed applications. In addition, these constituent components are easily available. However, it should be understood that any suitable slurry can be used in alternative examples.

[0042] In some arrangements, the powder in the slurry is present in an amount below the corresponding saturation of the associated liquid. However, the liquid is delivered to the target lumen before the powder is completely dissolved in the liquid. In this way, the undissolved powder can still interact with the target lumen to be cleaned.

[0043] In addition, it should be understood that the slurry can be produced / obtained in any of a variety of ways. For example, in some embodiments, the powder is obtained from a box or other consumable chamber / container, the water is obtained from a faucet, and these constituent components are mixed in a holding chamber (or in the consumable chamber itself) when the cleaning time is close (e.g., within a few days or weeks). This method may be advantageous because powders such as sodium bicarbonate can be relatively stable and can have a long shelf life, and suitable water sources are readily available. However, in other embodiments, the slurry can be obtained in an already mixed form.

[0044] As described above, method 240 involves distributing the slurry into suitable amounts, sometimes referred to as cleaning liquid masses in this article. As shown in the figure, the distributing amount is then delivered through the lumen to be cleaned. It may be advantageous to deliver discrete amounts of slurry, because discrete amounts can be delivered periodically at a suitable speed, and the periodic application of the composition can help promote the cleaning of the lumen without blocking / blocking the target lumen. In addition, the discrete nature of the amount delivered can promote the maintenance of a suitable delivery speed, which can also help cleaning. For example, if the slurry is delivered continuously (rather than in a discrete distributing amount), this method may have a 'blocking' or otherwise blocking lumen, thereby reducing the speed at which the slurry flows through the lumen, and may thus affect the risk of cleaning efficacy.

[0045] It is noteworthy that different amounts of slurry may be differently adapted to different characteristics of lumens to be cleaned. For example, the air / water channels within an endoscope are typically in the narrowest lumens, and therefore, may be more suitable for cleaning with a relatively small amount of slurry (whereas using a larger amount of slurry may result in blocking such narrow channels). In contrast, the aspiration / biopsy channel of an endoscope is typically in the widest lumen, and therefore, is more suitable for cleaning with a larger amount of slurry. Thus, the amount of slurry assigned to clean a given lumen is a function of the geometry of the lumen to be cleaned. Of course, it should be understood that the amount of slurry assigned may also or alternatively be a function of any of a variety of parameters, including those associated with the target.

[0046] The amount of slurry to be dispensed can be determined in any of a variety of ways. For example, in some embodiments, a valve can be used to draw a target amount of slurry from a reservoir (such as a detergent box described elsewhere herein). In some embodiments, a self-regulating pressurization system is used to draw an appropriate amount of slurry from a reservoir.

[0047] As mentioned above, Figure 2A The method 240 further includes delivering the dispatched amount of slurry through at least a portion of the lumen to be cleaned. Generally speaking, a carrier fluid (such as air, water, etc.) is used to deliver (e.g., propel) the dispatched amount of slurry through at least a portion of the lumen to be cleaned at a suitable speed. The dispatched amount of slurry is delivered in a manner (e.g., a suitable size, a suitable speed, etc.) to provide a suitable physical interaction between the mixture and the wall of the lumen, meaning that the undissolved powder will physically contact the wall of the lumen or flow against the wall of the lumen to remove contaminants (e.g., bioburden) from the wall of the lumen. Of course, the dispatched amount of slurry can be delivered through the lumen in any suitable manner to enable cleaning of the lumen.

[0048] It is worth noting that method 240 may be iterated any number of times to facilitate cleaning of the lumen of the medical device. Figure 2B A cleaning bolus 248 (e.g., a dispensed amount of slurry) is shown being delivered through a lumen 252 to remove contaminants from the walls of the lumen, with the general direction of travel of the bolus 248 being indicated by arrow 261. That is, as shown, the lumen 252 has one or more contaminants 254 (e.g., bioburden) disposed on an inner surface / wall 256 of the lumen. The cleaning bolus 248 is further shown being delivered through the lumen 252 to physically interact with the walls of the lumen and thereby remove contaminants 254 from the lumen. The cleaning bolus 248 can be considered to be entrained in a carrier fluid, which in this example includes air (indicated by arrow 263).

[0049] In general, the cleaning liquid boluses proposed herein, such as cleaning liquid bolus 248, can have different forms / arrangements. For example, in certain embodiments, the cleaning liquid bolus proposed herein can be a relatively single / monolithic mass (e.g., potentially substantially blocking the lumen when traveling through the lumen), which is sometimes referred to herein as a "monolithic bolus". However, in other embodiments, the cleaning liquid bolus can be a "lump" or "cluster" of smaller lumps / groups that travel through the lumen as a loose group (e.g., potentially not blocking the lumen when traveling through the lumen), which is sometimes referred to herein as a "clustered liquid bolus". Figure 2B An example in which the liquid mass 248 is a clustered liquid mass is schematically illustrated.

[0050] In certain embodiments, during the life cycle of a cleaning bolus, the bolus may transition between different forms. For example, a bolus may be dispatched (initially generated) as a whole bolus, but then transitioned to a cluster bolus. This transition may occur prior to entering the lumen (e.g., in a delivery chamber) and / or while traveling through the lumen.

[0051] As mentioned above, Figure 2B Generally, a cleaning fluid bolus 248 is shown being delivered through lumen 252. In some examples, Figure 2B represents the first stage / period of the cleaning process, while Figure 2C 248 is delivered through lumen 252 (eg, Figure 2B As shown), the fluid flow is delivered through lumen 252 without any liquid slugs. Figure 2C 261, the fluid stream includes water 265, where the general direction of travel is again indicated by arrow 261. In some examples, the fluid stream (e.g., water 265) is configured to remove residue 247 from the lumen. The residue 247 can include, for example, some remaining portions of the contaminants 254 and / or portions of the slug 248 that may remain on the wall of the lumen 252 after the slug passes through (e.g., the slug can be divided into different clusters, some of which remain on the wall of the lumen 252). If present, the portions of the slug 248 that remain on the wall of the lumen 252 can assist in the cleaning process because these portions are flushed through the lumen 252 by the fluid stream.

[0052] Figure 2B and 2C Generally, an arrangement is shown in which the second stage (fluid flow) is interspersed between the delivery of cleaning liquid boluses. Figure 2B and 2C In some alternative embodiments, multiple boluses may alternatively be delivered simultaneously or sequentially through the lumen without separation (e.g., without fluid flow alone).

[0053] It should be understood that in various embodiments, any number of cleaning boluses may be delivered through the lumen. In general, using a series of discrete / individual cleaning boluses 248 may allow the individual cleaning boluses to maintain sufficient kinetic energy to pass through the lumen at a rate that allows the particles with the bolus to advantageously interact with the lumen wall and remove contaminants from the lumen wall, as compared to a single large flow rate.

[0054] As described above, the lumen cleaning process can be performed on a plurality of different lumens in a variety of different ways, such as described above with respect to Figure 2A , 2B As described in 2C. As background, about cleaning Figure 1 A specific example embodiment is described with reference to at least a portion of endoscope 100 of FIG.

[0055] More specifically, in one example cleaning process / cycle, one (1) bolus of cleaning liquid is emitted / injected into the water jet channel 128 through the water jet connector 138, nine (9) boluses of cleaning liquid are then emitted into the biopsy / suction channel 122 through the suction connector 137, one (1) bolus of cleaning liquid is then emitted into the water jet channel 128 through the water jet connector 138, three (3) boluses of cleaning liquid are then emitted into the distal section 122B of the biopsy / suction channel 122 through the biopsy valve 128, one (1) bolus of cleaning liquid is then emitted into the water jet channel 128 through the water jet connector 138, and then nine (9) boluses of cleaning liquid are emitted into the biopsy / suction channel 122 through the suction connector 137. The cleaning cycle may further include firing / emitting six (6) cleaning liquid boluses into air channel 124 via air connector 143 and firing six (6) cleaning liquid boluses into water channel 126 via water connector 141 (e.g., in parallel). Figure 2C As described, the emission of a cleaning bolus within each target lumen may be followed by a fluid stream. The cleaning bolus and fluid stream may be delivered via one or possibly multiple connectors (e.g., one connector for an air tube and one connector for an air / water bottle).

[0056] In some examples, approximately 180-200 grams of slurry can be used to clean a typical flexible GI endoscope. For example, approximately 80-100 grams can be used to clean a relatively large channel (e.g., the suction / biopsy channel 122), with a total of 21 injections and a delay of approximately 15 seconds between each injection. For relatively smaller channels (e.g., the air / water channel), the process can use approximately 60-80 grams, with a total of 12 injections and a delay of approximately 30 seconds between each injection. For other small channels (e.g., the water jet channel 128), the process can use approximately 10-20 grams, with a total of 3 injections and a delay of approximately 30 seconds between each injection. Similarly, each of these channels can also receive a subsequent fluid flow (e.g., after each cleaning liquid bolus), as described above with respect to Figure 2C as described.

[0057] As described above, the cleaning bolus is delivered to the target lumen at a speed suitable / sufficient to remove contaminants from the walls of the target lumen. The speed of the cleaning bolus may vary, for example, based on the properties of the target lumen, the properties of the slurry used to form the cleaning bolus, etc. In one illustrative example, for a relatively large lumen, the bolus speed may be about 1000 mm / sec.

[0058] In addition, the cleaning liquid mass can be within a specific pressure and fluid flow (air) range. In some examples, the cleaning liquid mass can be delivered at a pressure of up to about 26psi (air, note that this is adjusted by PPR as described below), up to about 24psi (water), etc. Example air flow measurement can include about 50SLPM (large channel unloaded), about 11-17SLPM (large channel during dosing), about 7-10SLPM (large channel during full load), about 5-7SLPM (small channel unloaded) and about 0.1SLPM (small channel during full load). It should be understood that these ranges and values ​​are merely illustrative. Further details related to the cleaning of medical device lumens are disclosed in PCT / AU2022 / 050568 of the applicant entitled "System and method for cleaning lumens with fluid compositions" filed on June 9, 2022, the contents of which are hereby incorporated by reference.

[0059] Figure 3is a schematic diagram showing a lumen cleaning device / apparatus 370, with which embodiments presented herein may be implemented. The lumen cleaning device 370 includes a plurality of connectors 372. The connectors 372 include at least one gas connector 374 for connecting the lumen cleaning device 370 to a gas supply (e.g., a compressed dry air supply), at least one water connector 376 for connecting the lumen cleaning device 370 to a water supply (e.g., a drinking water supply), and a device drain fitting 378.

[0060] As shown, the lumen cleaning device 370 also includes an interface / connector 380 for an endoscope adapter hose 382. The endoscope adapter hose 382 connects the lumen cleaning device 370 to one or more lumens of an endoscope (eg, endoscope 100).

[0061] As described above, in an example automated lumen cleaning process (such as that performed by lumen cleaning device 370), a powder is mixed with a liquid to form a slurry, which is then dispensed and caused to flow through at least one internal channel / lumen of a medical device to remove bioburden adhered to the walls of the lumen. Figure 3 In the example of Figure 3 The detergent box is connected to an interface (schematically represented by a dashed box in the figure), and is configured to store, transport and mix dry powder with a liquid (e.g., water) to form a slurry.

[0062] exist Figure 3 , the detergent cartridge 390 is shown within the lumen cleaning device 370. However, it should be understood that this particular relationship between the detergent cartridge 390 and the lumen cleaning device 370 is merely illustrative. For example, in other embodiments, the detergent cartridge 390 can be partially or entirely located outside the lumen cleaning device 370 (e.g., interfaced with external components of the lumen cleaning device 370). Further details of an example detergent cartridge for an interface within a lumen cleaning device such as the lumen cleaning device 370 are provided below.

[0063] For ease of description, aspects of the technology presented herein will generally be described with respect to dispensing of detergents in powder form and fluid cleaning compositions in slurry form. However, as described elsewhere herein, the technology presented herein can be used with other types of detergents and other types of fluid cleaning compositions.

[0064] More specifically, Figure 44 is a schematic diagram showing a detergent box 490 according to various embodiments of the present invention, the detergent box includes a tank portion (tank) 491 and a closure assembly 492. As shown, the tank 491 includes a first (proximal) end 401, a second (distal) end 403, and defines an interior / interior volume 405. As shown, the closure assembly 492 includes a body 493 having at least two ports (referred to as a first port 494 and a second port 495) therein. The body 493 is configured to be attached to the first end 401 of the tank 491, and the ports 494 and 495 are configured to close the interior volume 405 of the box 490 (i.e., the area inside the tank 491) to prevent uncontrolled contact with the atmosphere, water or other contaminants, while being operable to allow material to move into and / or out of the box when desired by the user or, for example, at a predetermined time in an automatic cleaning cycle.

[0065] For ease of explanation, Figure 4 Only a single first port 494 and a single second port 495 are shown. However, it should be understood that there may be multiple first ports and / or multiple second ports. As further described below, the first port and the second port may be used to allow fluid to enter and exit, for example, to further assist in the hydration of the solid powder and / or the distribution of the slurry.

[0066] As further described below, detergent box 490 is configured to be attached to a cleaning device, which can then obtain box contents through ports 494 and 495. Ports 494 and 495 retain powder in box 490 until the box contents are dispensed in a controlled manner by the cleaning device. In certain embodiments, ports 494 and 495 can each include a port member that is configured to retain powder in box 490 at least initially. The port member can be, for example, a pressure-activated valve, a frangible membrane that is impermeable to fluids, etc.

[0067] More specifically, in one embodiment, ports 494 and 495 each have a valve (e.g., a valve with a preferred direction, a two-way valve, etc.), which is actuated by a pressure difference on the valve (e.g., produced by air, water, or an external mechanical element such as a pin). That is, the cleaning device can generate enough pressure difference on the valve to allow fluid to enter, and as described below, hydrate the powder and / or distribute the resulting slurry with a liquid (e.g., water). The valve can be configured to remain permanently open once actuated, or they can be configured to close once the pressure difference is removed. In some examples, the first port 494 and / or the second port 495 can include, for example, a stopcock, a butterfly valve or a needle valve, or an elastic flap, a pinch valve, a cross-slit valve, a dome valve, etc. Once the valve has been actuated, the device can prevent the removal of the box until the contents of the box have been consumed by the device.

[0068] In alternative embodiments, the first port 494 and / or the second port 495 can be a septum in the form of a fragile or pierceable membrane that can be pierced by a piercing assembly such as a needle or cannula and self-seals around the piercing assembly when the piercing assembly remains in place, and then substantially or completely self-seals when the piercing assembly is withdrawn. Typical materials for such fragile or pierceable membranes include butyl rubber or silicone rubber, but any suitable material may be selected given its relative inertness to the intended contents of the box. For ease of description, this article describes embodiments primarily with respect to the first port 494 and / or the second port 495 as pressure-actuated valves.

[0069] like Figure 4 As shown, the closure assembly further includes a riser (e.g., conduit) 496 extending from the first port 494 into the interior 405 of the tank 491. The riser 496 has a distal end 497, which in this example is adjacent to the second end 403 of the tank 491. The function of the riser 496 is to allow any flow through the first port 494 to occur only through the riser 496.

[0070] exist Figure 4 In the example of , the closure assembly 492 is configured to close the canister 491 and operate an interface with a lumen cleaning device 370 (e.g., a medical device lumen cleaning device, a food or beverage system cleaning device, a dental line cleaning device, etc.) and support internal structures in the box that facilitate mixing and dispensing of the slurry.

[0071] In certain embodiments, a detergent box 490 may be provided to a user containing an optionally predetermined amount of water-insoluble or partially water-soluble solid particles. The particles may be in a dry form and may be unaggregated, i.e., in a granular form. The solid particles may exist as a flowable solid, and the detergent box 490 may be a disposable consumable.

[0072] As used herein, a water-soluble particle is a particle that has partial solubility in water, such that the particle in a saturated solution of the water-soluble solid can be formed in a desired volume of water. An example of a suitable particulate material is sodium bicarbonate.

[0073] Sodium bicarbonate can provide a useful solid volume fraction in the slurry with little waste in the form of dissolved material. However, according to embodiments of the present invention, any other particulate material with a suitable solubility may be used, for example, anhydrous sodium carbonate, potassium carbonate, potassium bicarbonate with a solubility of 30 g / L at 20° C. may also be used. Other compounds may also be used, including amino acids such as glycine.

[0074] Protecting the contents of the detergent cartridge 490 from moisture prior to use can be a significant challenge. For example, in an example where the solid material is sodium bicarbonate, even relatively low moisture content can cause the contents to degrade. Low moisture permeability (e.g., less than 10 mg / day / liter) may be desirable to prevent premature decomposition of the sodium bicarbonate. In other cases, moisture may cause the contents to clump or agglomerate over time, which may adversely affect the flowability of the material and rapid mixing with the liquid component.

[0075] Thus, according to certain embodiments presented herein, it is advantageous to provide a substantially airtight seal between the closure assembly 492 and the can 491 to prevent moisture from entering at this joint. The airtight seal between the closure assembly 492 and the can 491 can be provided in a variety of different ways (e.g., by thread lock connection, press fit, welding, etc.). In addition, the box components (e.g., the closure assembly 492 and the can 491) can be formed of any one or more suitable moisture-impermeable materials that are chemically inert to the initial contents and / or slurry and have sufficient mechanical strength not only as a package, but also for use with a cleaning device.

[0076] More specifically, in the life cycle of detergent box 490, it can be conceptually understood as having two discrete states. Under the initial state, detergent box 490 not only works as a moisture barrier, but also as the physical protection to content, so as to be delivered to the user and stored by the user. However, as further described below, detergent box 490 is also configured to engage / interface with cleaning device. Once detergent box 490 engages with cleaning device, detergent box 490 just works as a part of fluid system, wherein the powder in detergent box 490 can be hydrated with liquids such as water, and is pressurized to help the resulting slurry to be delivered to the lumen. Like this, closed assembly 492 and tank 491 are formed (for example, as packaging and as the component of a larger fluid system) by the material that allows detergent box 490 to operate under these two states.

[0077] In certain embodiments, the closure assembly 492 and / or the canister 491 can be formed from one or more of polyethylene, polypropylene, polyethylene terephthalate, polystyrene, aluminum, glass, or aluminum or glass coated with polyethylene, polypropylene, polyethylene terephthalate, polytetrafluoroethylene, etc. In one specific example, high-density polyethylene (HDPE) can be relatively effective as a moisture barrier, blocking moisture at a level of less than 10 mg / day / liter.

[0078] Additionally, exposure to light and / or heat (above 60°C) may cause the contents to decompose. Temperature controlled manufacturing, storage and transportation of the product and protection from light can be controlled by using light-blocking materials for the box or a coating or packaging of the box.

[0079] To prevent inadvertent exposure of the contents to moisture prior to use, the closure assembly 492 may be provided with an additional cover 498 (e.g. Figure 5 494 and 495. For example, the additional cover 498 can be in the form of a liner that is sealed around the perimeter of the closure that the user can peel off (e.g., a plastic or foil liner, a composition of several polymer layers with an aluminum foil layer, etc.). The transfer of dry powder can be another problem, especially when transferred in a high moisture environment. To solve this problem, when connected to the device, the box operates as a powder reservoir, thereby avoiding the problem of dry powder transfer. The device hydrates the dry powder (e.g., with a liquid such as water), produces a slurry, and then transports the slurry from the box to the device as needed.

[0080] As mentioned above, Figure 4 An embodiment of a detergent cartridge 490 is shown that includes a first port 494 and a second port 495. Also as described above, the presence of two ports is merely illustrative, and certain embodiments presented herein may include one or more additional first ports (e.g., each port having an associated riser tube) and one or more additional second ports. For example, Figure 6 is a schematic diagram showing a detergent box 690, which includes a tank portion (tank) 691 and a closure assembly 692. Figure 4 Similar to the embodiment of the invention, the canister 691 includes a first end 601, a second end 603, and defines an interior / interior volume 605. The closure assembly 692 includes a body 693 having at least three (3) ports therein (referred to as a first port 694, a second port 695A, and a second port 695B). Figure 4 Similarly, the body 693 is configured to attach to the first end 601 of the tank 691, and the ports 694, 695A and 695B are configured to close the interior volume 605 of the box 690 (i.e., the area inside the tank 691) from uncontrolled contact with the atmosphere, water or other contaminants, while being operable to allow material to be moved into and / or out of the box when desired by the user or at predetermined times such as in an automatic cleaning cycle. The ports 694, 695A and 695B may have the same configuration as described above with respect to Figure 4 Any of the arrangements described and may be located anywhere on the closure assembly 692.

[0081] Fig. 7A , 7B , 7C and 7D are a series of schematic diagrams illustrating the operation of a cleaning agent cartridge having a lumen cleaning device for mixing and dispensing hydrated solid powders (slurries) according to certain embodiments presented herein. For ease of illustration only, Figures 7A-7DRegarding the first port 494 and the second port 495 ( Figure 4 ) and lumen cleaning device 370 ( Figure 3 ) are described together with the detergent box 490. Fig. 7A The cleaning agent cartridge 490 is shown separated from the lumen cleaning device 370, and Figures 7B-7D A detergent cartridge 490 is shown fluidly coupled to the lumen cleaning device 370. A device for cleaning, such as the endoscope 100, can be attached to the lumen cleaning device 370 simultaneously with the detergent cartridge 490.

[0082] According to certain embodiments proposed herein, the detergent box 490 initially has a certain amount of powder 411 distributed in the tank 491, and then the closure assembly 491 is attached to the tank 491 to close the tank. The detergent box 490 can be stored, transported and / or used in any orientation. However, in some examples, the detergent box 490 will typically be positioned in a lumen cleaning device (such as a lumen cleaning device 370) in a manner that the closure assembly 491 is maintained to be arranged below the base portion of the tank 491 (for example, in use, the tank 491 is arranged above the closure assembly 491). If necessary, during mixing and dispensing the hydrated powder (slurry), this orientation is conducive to the ventilation of the box 490.

[0083] As mentioned above, Fig. 7A The dry powder 411 is shown retained in the canister 491, and the riser 496 extends over the dry powder when the box 490 is in an orientation where the closure assembly 492 is below the canister 491. However, the canister 491 also includes a volume 412 of gas (e.g., air) to allow the dry powder 411 to move freely. In an alternative embodiment (not shown), the powder 411 can extend over the riser 496 when the detergent box 490 is in an orientation where the closure assembly 492 is below the canister 491.

[0084] like Figure 7B and 7C, the cleanser cartridge 490 is fluidly coupled to the lumen cleaning device 370, wherein the cleanser cartridge 490 may be, for example, on the interior, surface, etc. of the lumen cleaning device 370. In this example, the lumen cleaning device 370 includes a receptacle 715 to receive the cleanser cartridge 490 (e.g., the closure assembly 492) and hold it in a defined position so that the ports 494 and 495 in the closure assembly 492 are positioned so that they can be accessed by the port interfaces 721 and 723 of the lumen cleaning device 370, respectively. The port interfaces 721 and 723 may include openings / orifices configured to fluidly mate / couple with the corresponding ports 494 and 495 in the closure assembly 492 (e.g., provide a substantially fluid-tight seal with the ports 494 and 495). Additionally, in certain embodiments, the port interfaces 721 and 723 may include valve actuators that operate to open the ports 494 and 495.

[0085] In certain embodiments, the port interfaces 721 and / or 723 can receive a supply of gas or liquid at sufficient pressure to actuate / open the ports 494 and 495. For example, the gas or liquid can be supplied to create a pressure differential applied to the valve by the gas or liquid from the cleaning device for opening the ports 494 and 495 and allowing the gas or liquid to flow directly into the cartridge 490, or for pushing the gas, liquid, or slurry out of the cartridge 490. Alternatively, the port interfaces 721 and / or 723 can include mechanical components, such as push rods, baffles, cylinders, or other known devices, to enable fluid communication between the lumen cleaning device 370 and the canister 491 and control the flow of material into and out of the cartridge 490.

[0086] As mentioned above, it should be understood that the detergent box according to the embodiment proposed herein may include multiple first and / or second ports (e.g., a first port and two second ports), and these ports may be actuated by corresponding multiple correspondingly positioned valves on the device. In some cases where there are multiple ports, one or more ports may remain unactuated or blind. This arrangement enables a single box configuration to be used in cleaning devices of different configurations.

[0087] exist Figures 7A-7CIn the illustrated embodiment, the lumen cleaning device 370 is configured to distribute gas (e.g., air) from a gas source through a gas connector 374 and water from a water source through a water connector 376 into the cartridge 490 (e.g., through the port interface 721 and the first port 494) in a controlled manner. The lumen cleaning device 370 is also configured to discharge and / or exhaust the fluid through a drain line and a device drain fitting 378. Additionally, the lumen cleaning device 370 is configured to control various mixing parameters, such as air and water pressures and the time they are applied to the cartridge 490, the total volume and flow rate of air and water entering and exiting the cartridge 490, and the like. In certain examples, the lumen cleaning device 370 operates under the control of a computing device. Furthermore, the lumen cleaning device 370 is capable of controlling the slurry to flow out of the cartridge 490 through the second port 495 and the port interface 723, and again at a controlled flow rate most typically under the control of a computing system (e.g., as Fig. 9 The fluid cleaning composition is directed and / or advanced into the lumen of the endoscope 100 (via the connector 380) by a delivery mechanism 757 (as shown). In some examples, the slurry is advanced into the lumen of the endoscope 100 by a delivery mechanism 757. In some examples, the delivery mechanism may be implemented as described in commonly owned International Patent Application No. PCT / AU2022 / 050568 filed on June 9, 2022, the contents of which are hereby incorporated herein by reference.

[0088] As described above, the detergent cartridge 490 is engaged with the lumen cleaning device 370, for example, via a socket 715 that is configured (e.g., shaped and / or sized) to mate with at least a portion of the exterior portion of the closure assembly 492. The closure assembly 492 and / or the socket 715 may further include positioning, engaging and / or retaining components to help position the cartridge 490 in the correct position. For example, the closure assembly 492 may contain positioning one or more lugs 717 that facilitate bayonet-type connection with the device through a complementary slot 719.

[0089] It should be understood that the specific lug and slot engagement is merely illustrative, and that the detergent cartridge may be engaged with the lumen cleaning device in other ways. For example, in alternative embodiments, the closure assembly 492 may include external threads configured to mate with corresponding threads of the receptacle 715 having a stop to ensure proper orientation of the port with the valve in the lumen cleaning device 370. In certain embodiments, the lumen cleaning device 370 may include a locking mechanism (not shown) to prevent manual removal of the detergent cartridge 490 from the device until the mixing cycle, the dispensing cycle, and the cleaning cycle when in use are completed.

[0090] Once the detergent cartridge 490 is fluidly coupled to the lumen cleaning device 370, ports 494 and / or 495 are actuated in a desired manner by one or more port interfaces (e.g., valve actuators) 721 and / or 723, respectively, to allow the device to hydrate the contents of the tank 491. More specifically, in one example, the port interface 721 actuates and opens the first port 494, placing the orifice of the port interface 721 in fluid communication with the riser tube 496. The port interface 721 allows gas or liquid to flow into the cartridge 490.

[0091] Figure 7B , 7C 7D and 7D show the cartridge 490 in use and attached to the lumen cleaning device 370, but each of these figures represents a different stage / phase of operation. Figure 7B During the period shown, in this example, the first port 494 has been opened through the port interface 721, and water enters the tank 491 through the riser 496. In this way, the hydration of the powder 411 begins at a position referred to herein as the "first hydration site" 427, which is close to the distal end 425 of the riser 496. That is, water is made to flow through the port interface 721, and the path of the hydration water is shown as H1 (i.e., initially through the riser 496). Then, the water leaves the hydration path at the distal end 425 of the riser, and first contacts with the dry powder 411 adjacent to it. During this period, the hydration path therefore extends into the tank, and the first hydration site is located at a distance from ports 494 and 495. For example, the first hydration site can be located at the midpoint of the tank 491, or further away from ports 494 and 495, such as 50%, 75% or more of the distance relative to the closure assembly 492 toward the distal end of the tank. In other words, the first hydration site may be located within the distal 1 / 2, distal 1 / 3, or distal 1 / 4 of the canister 491. The flow of water into the first port 494 is then stopped after, for example, a certain period of time, a certain amount of water delivered, and the like.

[0092] Next reference Figure 7C , once the first port 494 provides hydration water, the flow stops, and the second port 495 is opened by the port interface 723, and the hydration of the powder 411 can be started at what is called "second hydration site" 429 subsequently. In this example, water flows by the port interface 723, and as shown, near the near end 401 of the water entering the tank. In this case, the path of the hydration water is shown as H2. Meanwhile, the first port 494 can reopen (for example, by pressure accumulation), thus allowing the gas at the far end 403 of the box 490 to be discharged by the riser 496. The discharge flow that can be discharged by the device discharge fitting 378 is generally shown by arrow V1. The water flow entering the second port 495 and the air flow flowing out of the first port 494 then stop after, for example, a certain period of time, delivering a certain amount of water, etc.

[0093] As mentioned above, Figure 7B and 7C The first hydration period and the second hydration period are shown respectively, which hydrate the powder 411 from two discrete locations (ie, the first hydration site 427 and the second hydration site 429). It should be understood that Figure 7B and 7C The first hydration period and the second hydration period shown can be repeated multiple times, for example in an alternating sequence, until the initial powder 411 is fully hydrated to form a slurry. The number of times each of the first hydration period and the second hydration period is performed can vary, for example, for different size containers, different powders, different hydration parameters, etc.

[0094] In some examples, the control loop can be operated to set the repetition / iteration of the first hydration period and the second hydration period. For example, the control system can control the operation based on predetermined data, or in some cases, using real-time data measurements, such as water flow rate, pressure data (e.g., from a pressure sensor in the container and / or cleaning device), rheological data (e.g., data related to the output flow from the box), etc. The controller can set, for example, the number of repetitions of the first hydration period and the second hydration period, the time period for introducing water into the box (e.g., opening the first port 494 for 2 seconds), etc.

[0095] It should also be understood that Fig. 7A and 7B As shown, the first hydration period and the second hydration period may not be performed sequentially, but may be performed substantially simultaneously in some embodiments. For example, in an alternative embodiment, the first port 494 and the second port 495 may be opened simultaneously, and the hydration of the powder 411 may start at both the first hydration site and the second hydration site simultaneously.

[0096] As mentioned above, Figure 7B and 7C The cartridge 490 is shown configured to hydrate the solid powder 411 contained therein at two separate hydration sites via different paths H1 and H2. This is to address the fact that single-point hydration from the outside of a solid mass may be problematic. For example, dispensing water only from the top may result in the formation of trapped air pockets, while dispensing only from the bottom may result in floating solid pockets, both of which may ultimately result in inefficient and / or partially homogenized hydration of the contents.

[0097] Introducing water at two points can reduce the likelihood of agglomeration and further aid in mixing the water with the solid powder 411. Even if poor solid-liquid mixing is relatively temporary, it can distort the relative water / solid ratio exiting the box. Therefore, good mixing of solids and liquids can be important, and it should be remembered that while mixing can be checked and assisted in a manual process, in an automated process it can be beneficial for each mix to produce reproducible and predictable results. In some examples, the amount of water can be calculated taking into account the amount of powder present in the tank and the target solids fraction desired for the slurry.

[0098] Back to Figures 7A-7D In one embodiment, once the hydration of powder 411 has reached a desired level by adding an appropriate amount of water, the addition of water is terminated and the resulting slurry can be dispensed for cleaning, for example, the lumen of endoscope 100. Fig.7D The contents of the detergent cartridge 490 are shown as the resulting slurry 431 (i.e., hydrated powder). As described elsewhere herein, in some examples of slurry 431, the water has partially dissolved the solid powder 411 to form a saturated solution in which no additional solids will dissolve, and the solid particles are suspended. The slurry may experience some settling, and there may be a thin layer of water or saturated solution above the slurry, but this can be taken into account and the relative effects can be adjusted in advance.

[0099] In certain embodiments, such as Fig.7D , the slurry is dispensed through the second port 495 for use by the cleaning device in cleaning the endoscope 100. In some embodiments, the port interface 721 can be used to introduce air and / or water through the first port 494. There may be some air compression in the headspace as air and / or water enters the cartridge, the hydration path H1 of the flow, but generally speaking, the water introduced through the first port 94 displaces the slurry 431 through the port 495. The orientation of the outlet 495 at the lower end of the container 490 ensures that the slurry 431 is dispensed to the cleaning device 370. The slurry 431 exits through the path S1 and can be propelled by the delivery mechanism 757 into the endoscope 100, where it performs the desired cleaning and then exits for disposal.

[0100] In certain embodiments, the flow of the slurry 431 can be regulated by the cleaning device 370, i.e., the delivery mechanism 757. For example, the delivery mechanism 757 can be provided with (e.g., by a pump) a dispensed amount of the slurry 431 from the cartridge 490, and then advances the dispensed amount of the slurry 431 into the lumen of the endoscope 100. Commonly owned International Patent Application PCT / AU2022 / 050568, filed on June 9, 2022, describes an example delivery mechanism that can be used with the cartridge 490, the contents of which are hereby incorporated herein by reference. In alternative embodiments, for example, the slurry 431 can be advanced directly into the lumen of the endoscope 100 by pressure generated by air and / or water entering the container 490 via the first port 494.

[0101] As described elsewhere herein, the slurry 431 can be dispensed in a variety of different ways. For example, the slurry 431 can be dispensed to a specific lumen to be cleaned in a selected / configured dispensed amount. Thus, the slurry 431 can be dispensed within multiple cycles.

[0102] In certain embodiments, once the slurry 431 has been dispensed from the cartridge, the cartridge can be rinsed with water, drained, and dried through one or more ports. That is, the cartridge 490 can be rinsed with water (e.g., through port 494), drained (e.g., through port 495), and blown dry with air (e.g., through ports 494 and / or 495). In this manner, the cartridge can then be removed substantially clean and dry, which can improve convenience and safety.

[0103] As mentioned above, Figures 7A-7D It has been described with respect to an embodiment in which the cartridge 490 includes a single first port and a single second port. However, as also described above, this particular arrangement is merely illustrative, and in alternative embodiments, there may be multiple first ports and / or multiple second ports. Figure 6 One such embodiment is shown in which a cartridge 690 includes one first port 694 and two second ports, referred to as second ports 695A and 695B. Figures 8A-8F is a series of diagrams illustrating the operation of the cartridge 690. For ease of illustration, Figures 8A-8F They will be described together, and the cartridge 690 is shown separated from the associated cleaning apparatus.

[0104] First reference Fig. 8A , a perspective view of a portion of a cartridge 690 , namely a closure assembly 692 and a first (proximal) end 601 of a can 691 , is shown. Fig. 8A A first port 694, a second port 695A, and a second port 695B are shown. Fig. 8AAlso shown in the figure is an anti-tamper feature 677 on the closure assembly 692 that prevents the closure assembly 692 from being disconnected from the can 691 (e.g., twisted off the can), which in turn helps protect the contents of the box from moisture ingress. In one form, the tamper feature 677 is in the form of teeth that are configured to engage with a set of complementary teeth provided on the can 691.

[0105] In certain embodiments, the first port 694, the second port 695A, and the second port 695B are formed of a thermoplastic elastomer material, and a plastic fastening feature (e.g., plastic tamper-evident feature 677) is used with the closure assembly 692. The use of these materials can enable the entire cartridge 690 (e.g., can 691 and closure assembly 692) to be recycled without the need to disassemble / separate the individual components.

[0106] Figure 8B It is along Fig. 8A 8B-8B of the cross-sectional view of the box 690 intercepted, and represents the first period / stage of the hydration process. In this example, water is added by the first port 694, and the second port 695A, 695B remain closed. More specifically, in this example, the first port 694 has been opened, and water enters the tank 691 through the riser 696. Like this, the hydration of the powder 611 begins at the "first hydration site" 627 near the far end 625 of the riser 696. That is to say, water leaves the hydration path at the far end 625 of the riser 696, and first contacts with the dry powder 611 adjacent to it. During this period, the hydration path therefore extends into the tank, and the first hydration site is located at a distance from ports 694, 695A and 695B. For example, the first hydration point can be located at the midpoint of the tank 691, or further away from the ports 694, 695A, and 695B, such as 50%, 75%, or more of the distance toward the distal end of the tank relative to the closure assembly 692. In other words, the first hydration point 627 can be located within the distal 1 / 2, distal 1 / 3, or distal 1 / 4 of the tank 691. The flow of water into the first port 694 is then stopped after, for example, a certain period of time, a certain amount of water is delivered, when a pressure set point is reached, etc.

[0107] Figure 8C It is along Fig. 8A The cross-sectional view of the box 690 taken along the section line 8C-8C shows an aspect of the second period / stage of the hydration process, while Figure 8B , 8D and 8E is along Fig. 8AA cross-sectional view of the cartridge 690 taken along section line 8B-8B of FIG. 8 shows another aspect of the second phase / stage of the hydration process. In this second stage, air is removed from the distal end of the cartridge 690 through the first port 694 (which is vented to atmosphere via a vent line), while water is added through the second ports 695A and 695B.

[0108] More specifically, if Figure 8C As shown, once hydration water is provided through the first port 694 in the first stage, the flow is stopped and the second ports 695A and 695B are opened and hydration of the powder 611 can then begin at what is referred to as the "second hydration site" 629. In this example, the water enters near the proximal end 601 of the canister and in this case the two paths of hydration water are shown as H2. Fig.8D , the first port 694 can be reopened, thereby allowing fluid (e.g., gas or saturated solution) to be discharged from the distal end 603 of the box 690 through the riser tube 696. The discharge flow is generally represented by arrow V1. The flow of water into the second ports 695A and 695B and the flow of air out of the port 694 are then stopped, for example, after a certain period of time, a certain amount of water is delivered, etc.

[0109] As mentioned above, Figure 8B A first hydration stage associated with cartridge 690 (e.g., hydration at first hydration site 427) is shown, while Figure 8C and 8D The second hydration stage associated with the box 690 (e.g., hydration at the second hydration site 429) is shown together. It is worth noting that Fig.8D The state of the contents of a box 690 having two simultaneous parts, including a first part containing partially hydrated powder 611 and a second part containing a saturated solution forming a fluid cleaning composition 631, is shown. This particular state of the contents of the box 690 can represent, for example, the contents after one or two iterations of a first hydration stage and a second hydration stage. In practice, the first hydration period and the second hydration period can be repeated multiple times, for example, in an alternating sequence, until the initial dry powder 611 is fully hydrated to form a slurry 631. The number of times each hydration period in the first hydration period and the second hydration period is performed can vary, for example, for containers of different sizes, different powders, different hydration parameters, etc.

[0110] Once the desired level of hydration of powder 611 has been achieved by adding an appropriate amount of water, the addition of water is terminated and the resulting fluid slurry 631 can be dispensed for cleaning, for example, the lumen of an endoscope. Fig. 8E and 8FThe contents of the detergent cartridge 690 are shown as the resulting slurry 631 (ie, hydrated powder), and the dosing / dispensing of the slurry 631. In this example, water is delivered through a first port 694, and the slurry 631 is dispensed through a second port 695A and / or a second port 695B.

[0111] In some embodiments, the slurry 631 can be advanced into the lumen, for example, by a delivery mechanism within the lumen cleaning device. For example, the delivery mechanism can extract (e.g., pump) a dispensing amount of the slurry 631 from the cartridge 690 and then advance the dispensing amount of the slurry 631 into the lumen of the endoscope 100 through the port 695A and / or the port 695B, as shown by the exit paths S1 and S2. Commonly owned international patent application PCT / AU2022 / 050568, filed on June 9, 2022, describes an example delivery mechanism that can be used with the container 690 to advance the dispensing amount of the slurry 631 into the lumen, the contents of which are hereby incorporated by reference herein.

[0112] In alternative embodiments, the slurry 631 can be pushed into the lumen of the endoscope 100 by pressure generated by air and / or water entering the container 790 via the first port 694, for example. In one such embodiment, fluid enters the cartridge 690 through the first port 694 along the hydration path H1 and displaces a quantity of the slurry 631. The displaced slurry 631 is dispensed through the ports 695A and / or 695B, as shown by the outlet paths S1 and S2. The orientation of the outlet ports 695A and / or 695B at the lower end of the container 690 ensures that the slurry 631 is dispensed to the cleaning device.

[0113] Generally speaking, the plurality of second ports 695A and 695B are included. Figures 8A-8F The embodiment can allow the slurry to leave the container 690 more quickly. Multiple second ports 695A and 695B can be used to provide multiple slurry flows to clean multiple endoscope channels and / or multiple endoscopes, or multiple slurry flows can be recombined to provide a higher flow rate of slurry 631.

[0114] As mentioned above, for ease of description, the various aspects of the technology proposed herein are generally described above about the distribution of the cleaning agent in powder form and the fluid cleaning composition in slurry form. However, it should be understood that the technology proposed herein can be used together with other types of cleaning agents and other types of fluid cleaning compositions. For example, in an alternative embodiment, the initial contents of the container can be a concentrate (e.g., disinfectant), to which fluid (e.g., water) is added to dilute the concentrate to the appropriate level for use as a cleaning composition. In other words, in the above description, potentially by some modifications to the workflow, powder can replace liquid or other cleaning agents, to form a resulting fluid cleaning composition for distribution and for cleaning, for example, a lumen.

[0115] As described elsewhere herein, hydration of the cleaning agent (eg, powder) in the cleaning agent cartridge and dispensing of the resulting fluid cleaning composition can be controlled by a control system. Fig. 9 is a block diagram showing an example computing device 917 configured to operate as a control system for hydration and dispensing, as described elsewhere herein. The computing device 937 also operates as a control system for a lumen cleaning device. The computing device 937 may include, for example, a personal computer, a server computer, a handheld device, a laptop device, a multiprocessor system, a microprocessor-based system, a programmable consumer electronics product (e.g., a smartphone), a network PC, a minicomputer, a mainframe computer, a tablet computer, a remote control unit, a distributed computing environment including any of the above systems or devices, etc. The computing device 937 may be a single virtual or physical device operating in a networked environment through a communication link to one or more remote devices, such as an implantable medical device or an implantable medical device system.

[0116] In its most basic configuration, computing device 937 includes at least one processing unit 945 and memory 947. Processing unit 925 includes one or more hardware or software processors (e.g., central processing units) that can obtain and execute instructions. Processing unit 945 can communicate with other components of computing system 937 and control their performance.

[0117] The memory 937 is one or more software or hardware-based computer-readable storage media that can be operated to store information that can be accessed by the processing unit 945. The memory 947 can store instructions and other data that can be executed by the processing unit 945 to implement applications or to perform operations described herein. The memory 947 can be a volatile memory (e.g., RAM), a non-volatile memory (e.g., ROM), or a combination thereof. The memory 947 can include a temporary memory or a non-temporary memory and / or one or more removable or non-removable storage devices. In an example, the memory 947 can include RAM, ROM, EEPROM (electrically erasable programmable read-only memory), flash memory, optical disk storage device, magnetic storage device, solid-state storage device, or any other storage medium that can be used to store information for later access. In an example, the memory 947 covers a modulated data signal (e.g., a signal that sets or changes one or more of its characteristics in a manner that encodes information in the signal), such as a carrier or other transmission mechanism, and includes any information delivery medium. By way of example and not limitation, the memory 947 may include wired media such as a wired network or direct wired connection, and wireless media such as acoustic, RF, infrared, and other wireless media or combinations thereof. In certain embodiments, the memory 947 contains box control logic 949 that, when executed, enables the processing unit 945 to perform aspects of the presented technology.

[0118] In the illustrated example, the system 937 further includes a network adapter 951, one or more input devices 953, and one or more output devices 955. The system 937 may include other components, such as a system bus, component interfaces, a graphics system, a power source (e.g., a battery), and other components. The network adapter 951 is a component of the computing system 937 that provides network access (e.g., access to at least one network). The network adapter 951 may provide wired or wireless network access and may support one or more of a variety of communication technologies and protocols, such as Ethernet, cellular, Bluetooth, near field communication, and RF (radio frequency), etc. The network adapter 931 may include one or more antennas and related components configured for wireless communication according to one or more wireless communication technologies and protocols.

[0119] One or more input devices 953 are devices through which the computing system 937 receives input from a user. One or more input devices 953 may include physically actuatable user interface elements (e.g., buttons, switches, or dials), touch screens, keyboards, mice, pens, and voice input devices, among other input devices. One or more output devices 955 are devices through which the computing system 937 can provide output to a user. Output devices 955 may include a display, one or more speakers, and other output devices.

[0120] It should be understood that Fig. 9 The arrangement of the computing system 937 shown in is merely illustrative, and aspects of the technology presented herein can be implemented on many different types of systems / devices. For example, the computing system 937 can be a laptop computer, a tablet computer, a mobile phone, a surgical system, etc.

[0121] Fig.10 1 is a flow chart showing an example method 1061 according to certain embodiments presented herein. Method 1061 begins at 1063, wherein at least one first port and one or more second ports of a box forming a closed container including at least one powder are fluidically connected to a cleaning device. At 1065, the cleaning device introduces a fluid into the box through at least one first port to at least partially hydrate the at least one powder. At 1067, the cleaning device introduces a fluid into the box through one or more second ports to at least partially hydrate the at least one powder. The fluid and the powder form a fluid cleaning composition. At 1069, the fluid cleaning composition is dispensed from the box through at least one of the one or more second ports.

[0122] Fig.11 1 is a flow chart illustrating another example method 1161 according to certain embodiments presented herein. The method 1161 begins at 1163, wherein a box forming a closed container and comprising at least one powder is fluidly connected to a cleaning device. At 1165, a fluid is introduced from a first hydration site in the box. At 1167, a fluid is introduced from a second hydration site in the box. The fluid and at least one powder form a fluid cleaning composition. At 1169, the fluid cleaning composition is dispensed from the box.

[0123] The detergent box and the related art presented herein can provide many advantages that are superior to other box systems.For example, according to some aspects proposed herein, the hydration of solid powder occurs at two positions, including the position of the proximal end of the adjacent container and the position of the more distal side (for example, the center or distal part of the container).The use of two hydration sites enables fluid (for example, water) to contact the solid material mass at two points, thus promoting uniform mixing.In addition, it can be beneficial to attach the box only by closing the assembly.In the present case, the volume required for the cleaning lumen (for example, the endoscope lumen) is not insignificant, so the mechanism with a fully built-in box will need to significantly increase the form factor.The single point attachment of the box is also conducive to alignment and removal, and minimizes the possibility of damage to the box or cleaning device.

[0124] In addition, according to the embodiments proposed herein, the mixing of powder and fluid occurs completely in the box, and the outside of the box remains dry. Many conventional box mixing and extraction systems cause the box to become wet after use and during removal. In addition to being inconvenient and messy, in an environment where medical devices are purified and reprocessed, if the user's hands or gloves are "dirty", a large amount of water may cause cross contamination of the small box during processing. Due to the fluid connection, there is no need to distribute / meter dry powder. Finally, the box of the present invention provides a plurality of ports, which are operable to allow fluid to enter and leave, and each port can provide the various functions discussed thereby.

Claims

1. A detergent box, comprising: a canister configured to hold a dry powder; a closure assembly configured to be attached to the can to form a closed volume; at least one first port disposed in the closure assembly, the at least one first port configured for fluid entry into the canister; a riser pipe extending from the at least one first port into the tank; as well as One or more second ports are disposed in the closure assembly, the one or more second ports being configured for fluid to enter the tank and fluid to exit the tank.

2. The detergent cartridge of claim 1, wherein the one or more second ports are operable to allow passage of slurry from the tank.

3. The cleaning agent kit of claim 2, wherein the slurry comprises a fluid cleaning composition.

4. The detergent cartridge of claim 1, wherein the at least one first port is configured to allow fluid to flow out of the canister.

5. The detergent cartridge of claim 1, wherein the distal end of the riser tube defines a first hydration site, and the one or more second ports define a second hydration site separate from the first hydration site.

6. The detergent cartridge of claim 1, wherein the one or more second ports include at least two second ports, each second port being configured for fluid to enter the tank and fluid to exit the tank.

7. The detergent cartridge of claim 1, wherein the at least one first port is configured for fluid to enter the tank and fluid to exit the tank.

8. The detergent cartridge of claim 1, wherein each of the at least one first port and the one or more second ports comprises a port member.

9. The detergent cartridge of claim 8, wherein the port member is a pressure activated valve.

10. The detergent cartridge of claim 8, wherein the port member is a frangible membrane that is impermeable to gas or liquid.

11. The detergent cartridge of claim 1, wherein the canister has a first end and a second end, the closure assembly being attached to the first end, and wherein the riser tube extends at least fifty percent of the distance between the first end and the second end.

12. The detergent cartridge of claim 11, wherein the riser tube extends at least seventy-five percent of the distance between the first end and the second end.

13. The detergent cartridge of claim 1, wherein the at least one first port is fluidly isolated from the one or more second ports within the closure assembly.

14. A method comprising: fluidly coupling at least one first port and one or more second ports of the cartridge to a cleaning device, wherein the cartridge forms a closed container including at least one powder; introducing a fluid into the cartridge through the at least one first port; introducing a fluid into the cartridge through the one or more second ports, wherein said fluid and said powder form a fluid cleaning composition; as well as The fluid cleaning composition is dispensed from the cartridge through at least one of the one or more second ports.

15. The method of claim 14, further comprising: Fluid is iteratively introduced into the cassette through the at least one first port and through the one or more second ports in an alternating sequence.

16. The method of claim 15, further comprising: The number of iterations of the alternating sequence is controlled based on one or more real-time measurements.

17. The method of claim 14, further comprising: Fluid is introduced into the cassette substantially simultaneously through the at least one first port and through the one or more second ports.

18. The method of claim 14, further comprising: Fluid is simultaneously expelled from the closed container while fluid is introduced into the cassette through the one or more second ports.

19. The method of claim 18, wherein simultaneously with introducing fluid into the cartridge through the one or more second chambers, expelling fluid from the closed container comprises: Gas is vented from the closed container while fluid is introduced into the cartridge through the one or more second ports.

20. The method of claim 14, wherein the one or more second ports comprises a plurality of second ports, and wherein dispensing the fluid cleaning composition through at least one of the one or more second ports comprises: The fluid cleaning composition is dispensed through each second port of the plurality of second ports.

21. The method of claim 20, wherein dispensing the fluid cleaning composition through each of the plurality of second ports comprises: The fluid cleaning composition is dispensed sequentially through the plurality of second ports.

22. The method of claim 20, wherein dispensing the fluid cleaning composition through each of the plurality of second ports comprises: The fluid cleaning composition is dispensed simultaneously through the plurality of second ports.

23. The method of claim 14, wherein the cassette includes a riser tube attached to the at least one first port, and wherein introducing a fluid into the cassette through the at least one first port comprises: Fluid is introduced through the distal end of the riser tube.

24. The method of claim 14, wherein the cartridge comprises a proximal end and a distal end, and wherein introducing a fluid into the cartridge through the one or more second ports comprises: Fluid is introduced through the proximal end of the cartridge.

25. The method of claim 14, wherein dispensing the fluid cleaning composition through at least one of the one or more second ports comprises: Fluid is introduced into the cartridge through the at least one first port to expel a corresponding volume of the fluid cleaning composition through the one or more second ports.

26. The method of claim 25, wherein introducing a fluid into the cartridge through the at least one first port to expel a corresponding volume of the fluid cleaning composition through the one or more second ports comprises: Liquid is introduced into the cartridge through the at least one first port.

27. The method of claim 25, wherein introducing a fluid into the cartridge through the at least one first port to expel a corresponding volume of the fluid cleaning composition through the one or more second ports comprises: Gas is introduced into the cartridge through the at least one first port.

28. The method of claim 14, wherein dispensing the fluid cleaning composition through at least one of the one or more second ports comprises: A quantity of the fluid cleaning composition is pumped from the cartridge through the one or more second ports.

29. The method of claim 14, wherein fluidly coupling at least one first port and one or more second ports of the cartridge to a cleaning device comprises: The proximal end of the cartridge is mechanically attached to a socket of the cleaning device.

30. The method of claim 14, wherein fluidly coupling at least one first port and one or more second ports of the cartridge to a cleaning device comprises: The at least one first port and the one or more second ports are aligned and engaged with corresponding port interfaces of the cleaning device.

31. The method of claim 14, wherein at least one first port and the one or more second ports each comprise a pressure actuated valve, and wherein the method comprises: The fluid is selectively provided to the one at least one first port or the one or more second ports at a pressure sufficient to actuate a corresponding pressure-actuated valve.

32. The method of claim 14, further comprising: The amount of fluid is controlled using a predetermined flow rate within a predetermined time or a predetermined pressure in the cassette.

33. The method of claim 14, wherein the fluid cleaning composition is a mixture of sodium bicarbonate or sodium carbonate in a saturated solution.

34. The method of claim 14, wherein dispensing the fluid cleaning composition from the cartridge through at least one of the one or more second ports comprises: extracting a dispensing amount of the fluid cleaning composition from the cartridge with a delivery mechanism; and The dispensed amount of the fluid cleaning composition is advanced into at least one lumen.

35. A method comprising: fluidly coupling a cartridge to a cleaning device, wherein the cartridge forms a closed container including at least one powder; introducing a fluid from a first hydration site within the cartridge; introducing fluid from a second hydration site within the cartridge, wherein said fluid and said at least one powder form a fluid cleaning composition within said cartridge; as well as The fluid cleaning composition is dispensed from the cartridge.

36. The method of claim 35, further comprising: Fluid is iteratively introduced into the cartridge from the first hydration site and the second hydration site in an alternating sequence.

37. The method of claim 36, further comprising: The number of iterations of the alternating sequence is controlled based on one or more real-time measurements.

38. The method of claim 35, further comprising: Fluid is introduced into the cartridge substantially simultaneously from the first hydration site and the second hydration site in an alternating sequence.

39. The method of claim 35, further comprising: Gas is evacuated from the closed container simultaneously with the introduction of fluid from the second hydration site within the cartridge.

40. The method of claim 35, wherein the cartridge has a proximal end and a distal end, and wherein introducing a fluid r from a first hydration site within the cartridge comprises: The fluid is introduced from a site relatively closer to the distal end than to the proximal end.

41. The method of claim 35, wherein the cartridge has a proximal end and a distal end, at least one first port at the proximal end of the cartridge, and a riser tube attached to the at least one first port, and wherein introducing a fluid from a first hydration site within the cartridge comprises: Fluid is introduced through the distal end of the riser tube.

42. The method of claim 35, wherein the cartridge has a proximal end and a distal end, and wherein introducing fluid from a second hydration site within the cartridge comprises: The fluid is introduced from a site relatively closer to the proximal end than to the distal end.

43. The method of claim 35, wherein the cartridge has a proximal end and a distal end and one or more second ports located at the proximal end of the cartridge, and wherein introducing fluid from a second hydration site within the cartridge comprises: Fluid is introduced through the one or more second ports.

44. The method of claim 35, wherein dispensing the fluid cleaning composition from the cartridge comprises: opening one or more second ports in the cassette; and The fluid cleaning composition is released through the one or more second ports.

45. The method of claim 44, wherein the one or more second ports comprises a plurality of ports, and wherein releasing the fluid cleaning composition through the one or more second ports comprises: The fluid cleaning composition is released through each port of the plurality of ports.

46. ​​The method of claim 45, wherein releasing the fluid cleaning composition through each of the plurality of ports comprises: The fluid cleaning composition is released sequentially through the plurality of ports.

47. The method of claim 45, wherein releasing the fluid cleaning composition through each of the plurality of ports comprises: The fluid cleaning composition is released simultaneously through the plurality of ports.

48. The method of claim 35, wherein dispensing the fluid cleaning composition from the cartridge comprises: Fluid is introduced into the cartridge to expel a corresponding volume of the fluid cleaning composition through one or more ports.

49. The method of claim 35, wherein dispensing the fluid cleaning composition from the cartridge comprises: A quantity of the fluid cleaning composition is pumped from the cartridge through one or more ports.

50. A box for storing a dry powder, for hydrating the dry powder to provide a slurry, and for dispensing the slurry; the box comprising: a closure assembly and a can, the can being closed by the closure assembly, The closure assembly comprises at least one first port operable to allow fluid to enter the tank or gas to flow out of the tank and one or more second ports operable to allow fluid to enter the tank and slurry to pass from the tank, The canister is adapted to hold the dry powder, wherein a conduit extends from the first port within the canister to define a first hydration site, and the one or more second ports define a second hydration site.

51. The cartridge of claim 50, wherein the closure assembly further comprises at least two second ports operable to allow fluid to enter the tank and / or to allow slurry from the tank to pass therethrough.

52. The cartridge of claim 50, wherein the first port is operable to allow liquid to flow from the canister.

53. The cartridge of claim 50, wherein the one or more second ports are operable to allow gas or liquid to flow from the canister.

54. The cartridge of claim 51 , wherein at least one of the at least two second ports is operable to allow liquid to flow from the tank.

55. The cartridge of claim 50, wherein each respective port comprises a port member resiliently held against a base.

56. The cartridge of claim 55, wherein the port member is a pressure activated valve.

57. The cartridge of claim 55, wherein the port member is a frangible membrane that is impermeable to gases or liquids.

58. The cartridge of claim 50, wherein the conduit extends at least 50% of the distance into the tank.

59. The cartridge of claim 50, wherein the conduit extends at least 75% of the distance into the tank.

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