Flufenoxuron-containing acaricidal composition

Abstract

The invention belongs to the technical field of pesticides, and relates to a flufenoxuron-containing acaricidal composition, the effective components of the acaricidal composition comprise an active component A and an active component B, the active component A is flufenoxuron, and the active component B is fenpyroximate; the mass ratio of the active component A to the active component B is (1: 45)-(50: 1). The pesticide composition or the preparation thereof can enhance the pesticide effect, expand the acaricidal spectrum, reduce the use cost, reduce the dosage, prolong the lasting period and delay the development of pesticide resistance.

Description

Technical Field

[0001] The invention relates to the technical field of pesticide compounding, and in particular to a flufenoxuron-containing acaricidal composition and application thereof. Background Art

[0002] Flufenoxuron is a benzoylurea insect growth regulator. It inhibits chitin synthesis and has a better effect on immature mites and insects. It is mainly used to control pests and mites on fruit trees such as apples and citrus, vegetables, cotton and other plants. It has a good control effect on pests such as spider mites, rust mites, leaf miners, diamondback moths, cabbage worms, cotton bollworms, borers and noctuids.

[0003] Pyflubumide is a new type of carboxanilide acaricide discovered and developed by Nippon Agricultural Chemicals Co., Ltd. It mainly inhibits succinate dehydrogenase to prevent succinate from being oxidized to fumaric acid, thereby inhibiting the mitochondrial respiratory chain of harmful mites and causing their death. It has a good control effect on spider mites and spider mites.

[0004] Phytophagous mites are a class of Acari in the Arthropoda class of the Animal Kingdom. They are the most common plant pests. They are small in size and mostly live in dense groups on the back of crop leaves, sucking and causing damage, resulting in a large reduction in the yield of fruit trees, cotton, vegetables and ornamental plants, causing serious losses. Spider mite larvae feed on the mesophyll cells of leaves, resulting in spots or curved marks on the leaf surface. Different types of spider mite larvae eat mesophyll cells in different locations; in addition, the wounds on the leaf surface left by the mites open the door to various diseases, which can induce plant diseases such as bacterial leaf spot.

[0005] Insecticides and acaricides have significant effects in preventing and controlling agricultural and forestry pests or urban health pests. The applicant surprisingly found through a series of experiments that the combination of flubendiamide and fenpyroximate has a significant synergistic effect, and the acaricide composition and application thereof have not been reported yet. Summary of the invention

[0006] Based on the above situation, the purpose of the present invention is to provide a miticide composition containing flubendiamide and its preparation, which are mainly used for controlling herbivorous mites. The miticide composition or its preparation can enhance the efficacy, reduce the dosage, and have a synergistic effect. At the same time, it can prolong the lasting effect and delay the development of drug resistance.

[0007] In order to achieve the above object, the present invention adopts the following technical scheme: a miticide composition containing flufenoxuron, wherein the effective ingredients of the miticide composition include active ingredient A and active ingredient B, wherein the active ingredient A is flufenoxuron, and the active ingredient B is fenpyroximate;

[0008] Furthermore, the mass ratio of flubendiamide to fenvalerate is 1:45 to 50:1;

[0009] Furthermore, the mass ratio of flubendiamide to fenvalerate is 1:45, 1:30, 1:17, 1:10, 2:5, 5:2, 10:1, 25:1, 35:1, 50:1;

[0010] Furthermore, the mass ratio of flubendiamide to fenvalerate is 1:30 to 35:1;

[0011] Furthermore, the mass ratio of flubendiamide to fenvalerate is 1:30, 1:17, 1:10, 2:5, 5:2, 10:1, 25:1, 35:1;

[0012] Furthermore, the mass ratio of flubendiamide to fenvalerate is 1:17 to 35:1;

[0013] Furthermore, the mass ratio of flubendiamide to fenvalerate is 1:17, 1:10, 2:5, 5:2, 10:1, 25:1, 35:1;

[0014] Furthermore, based on the total weight of the acaricidal composition being 100 wt%, the sum of the contents of the active ingredient A and the active ingredient B in the acaricidal composition is 1 to 95 wt%;

[0015] Furthermore, the sum of the contents of the active ingredient A and the active ingredient B in the acaricidal composition is 5 to 80 wt %;

[0016] In a preferred embodiment, the sum of the contents of flufenoxuron and fenpyroximate in the pesticide composition is 5 to 70 wt %, for example, the sum of the contents of flufenoxuron and fenpyroximate is 5%, 10%, 15%, 20%, 30%, 35%, 40%, 50%, 65%;

[0017] Furthermore, the acaricide composition includes, in addition to the active ingredients, auxiliary ingredients acceptable to agricultural production;

[0018] Furthermore, the auxiliary component is selected from one or more of a wetting agent, a dispersant, an emulsifier, a thickener, a disintegrant, an antifreeze agent, a defoaming agent, a solvent, a preservative, a stabilizer, a synergist, a carrier or a filler;

[0019] Further, the wetting agent is selected from one or more of alkylbenzene sulfonate, alkylnaphthalene sulfonate, lignin sulfonate, sodium dodecyl sulfate, sodium dioctyl succinate sulfonate, alpha olefin sulfonate, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, alkylphenol ethoxylate, fatty alcohol ethoxylate, fatty alcohol polyoxyethylene ether sodium sulfate, silkworm feces, saponin powder, soapberry powder, SOPA, detergent, emulsifier 2000 series and wetting penetrant F;

[0020] Furthermore, the dispersant is selected from one or more of polycarboxylates, lignin sulfonates, naphthalene sulfonates, naphthalene sulfonic acid formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether, fatty acid polyoxyethylene ester, fatty amine polyoxyethylene ether and glycerol polyoxyethylene ether fatty acid ester;

[0021] Furthermore, the emulsifier is selected from one or more of calcium dodecylbenzene sulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, phenylethylphenol polyoxyethylene polyoxypropylene ether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrylphenol polyoxyethylene ether, castor oil polyoxyethylene ether and alkylphenol ether phosphate;

[0022] Furthermore, the thickener is selected from one or more of xanthan gum, carboxymethyl cellulose, carboxyethyl cellulose, methyl cellulose, magnesium aluminum silicate and polyvinyl alcohol;

[0023] Further, the disintegrant is selected from one or more of sodium sulfate, ammonium sulfate, aluminum chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid and tartaric acid;

[0024] Furthermore, the antifreeze agent is selected from one or more of alcohols, alcohol ethers, chlorinated hydrocarbons and inorganic salts;

[0025] Furthermore, the defoamer is selected from silicone oil, silicone defoamer and C8~ 10 One or more of fatty alcohols;

[0026] Further, the solvent is selected from one or more of solvent oil S-200, xylene, trimethylbenzene, tetramethylbenzene, methylnaphthalene, methyl oleate, fatty acid methyl ester, pine base oil, soybean oil, biodiesel, sec-butyl acetate, dimethyl carbonate, diesel, white oil, engine oil, N-methylpyrrolidone and water;

[0027] Further, the preservative is selected from one or more of propionic acid, sodium propionate, sorbic acid, sodium sorbate, potassium sorbate, benzoic acid, sodium benzoate, sodium p-hydroxybenzoate, methyl p-hydroxybenzoate, kasone and 1,2-benzisothiazolin-3-one;

[0028] Further, the stabilizer is selected from one or more of disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, 2,6-di-tert-butyl-p-cresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, bentonite, attapulgite, white carbon black, talc, montmorillonite and starch; the synergist is selected from synergistic phosphorus and synergistic ether;

[0029] Further, the carrier is selected from one or more of ammonium salts, ground natural minerals, ground artificial minerals, silicates, resins, waxes, solid fertilizers, water, organic solvents, mineral oils, vegetable oils and vegetable oil derivatives;

[0030] Furthermore, the filler is selected from one or more of kaolin, diatomaceous earth, bentonite, white carbon black, light calcium carbonate, attapulgite, clay, talc, quartz sand, starch, alkyl polysaccharide, urea, potassium chloride and ammonium chloride;

[0031] Furthermore, the acaricide composition can be prepared into a formulation form permitted in agriculture, and the formulation form is selected from a solid formulation and / or a liquid formulation;

[0032] Furthermore, the solid preparation is selected from water dispersible granules and wettable powders; the liquid preparation is selected from emulsifiable concentrates, microemulsions, suspensions, and aqueous emulsions.

[0033] Use of a flufenoxuron-containing acaricidal composition for controlling herbivorous mites;

[0034] Furthermore, the herbivorous mites are Tetranychus, Mylidae and / or Eupodidae pest mites;

[0035] Furthermore, the herbivorous mites are Panonychus citri, Tetranychus cinnabarinus, and Tetranychus urticae;

[0036] Furthermore, the acaricidal composition is applied at an effective dose to the harmful mites to be controlled or to the medium where they grow.

[0037] Beneficial effects of the present invention:

[0038] (1) The acaricidal composition of the present invention has a good acaricidal effect and has a significant synergistic effect on acaricidal effect within a certain range, thereby improving the control effect of a single active ingredient compound in the composition on pests;

[0039] (2) The acaricide composition of the present invention reduces the amount of pesticides used, can delay the development of pesticide resistance in harmful mites, is safe, efficient, and environmentally friendly. DETAILED DESCRIPTION

[0040] In order to make the technical scheme, purpose and advantages of the present invention more clearly understood, the following specific examples are used to further illustrate the present invention in detail, but the present invention is by no means limited to these examples. The proportions of each component in the examples are all measured by weight.

[0041] Indoor biological activity assay

[0042] Examples Reference Pesticide Indoor Bioassay Test Guidelines Part 13: Leaf Disk Spray Method NY / T 1154.13-2008; Part 7: Determination of Combined Effects of Mixtures NY / T 1154.7-2006

[0043] Test material preparation

[0044] Test target: Panonychus citri McGregor, a susceptible strain reared indoors;

[0045] Select nymphs that are reared indoors and have consistent physiological conditions. Temperature: (25±1)℃. Relative humidity: 65%±5%, photoperiod: 16 / 8h (L / D).

[0046] Select citrus leaves of uniform growth, use a hole puncher to make leaf discs with a diameter of 2 cm, place agar in a culture dish to keep it moist, put filter paper on it, and put leaf discs on the filter paper, with 3 leaf discs per dish, inoculate the nymphs raised indoors onto the leaf discs, with 20 nymphs on each leaf disc.

[0047] Preparation of the drug: Use acetone to dissolve the original drug, and then dilute it with 0.1% Tween-80 aqueous solution. Prepare the single-dose mother liquor separately, and design 5 groups of proportions according to the purpose of mixing and the activity of the drug. Each single dose and each group of mixed proportions are prepared in 5 series of mass concentrations according to the equal ratio method.

[0048] Chemical treatment: Place the culture dish on the bottom plate of the Potter spray tower for spraying, the spray volume is 1mL, take out the chemical solution after settling for 1min, and transfer it to the feeding conditions for feeding. Each treatment is repeated at least 4 times, and the treatment without chemical is set as blank control.

[0049] Data statistics and analysis: 48 hours after treatment, check the mortality of test insects and record the total number of insects and the number of dead insects. Calculate the corrected mortality rate of each treatment based on the survey data.

[0050] Calculate according to the following formula, and keep the results to two decimal places:

[0051]

[0052] Where:

[0053] P——mortality rate, in percentage (%);

[0054] K——indicates the number of dead insects, in units of heads;

[0055] N——represents the total number of insects treated, in heads.

[0056] If the control mortality rate is less than 5%, no correction is required; if the control mortality rate is between 5% and 20%, correction should be performed according to the following formula; if the control mortality rate is greater than 20%, the test needs to be repeated.

[0057]

[0058] Where:

[0059] P1——adjusted mortality rate, in percentage (%);

[0060] P t ——Treatment mortality rate, expressed as percentage (%);

[0061] P0——blank control mortality rate, in percentage (%).

[0062] The data were processed using the probability value analysis method. The DPS statistical analysis system can be used to analyze and find the LC of the toxicity regression line. 50 The activity of the test agent on the biological test material was evaluated by using the value and its 95% confidence limit and R value.

[0063] The co-toxicity coefficient of the compound:

[0064] CTC ≥ 120 indicated synergistic effect;

[0065] CTC≤80 indicated antagonism;

[0066] 80<CTC<120 shows an additive effect.

[0067] The co-toxicity coefficient (CTC value) of the mixture is calculated as follows:

[0068]

[0069] Where:

[0070] ATI——Actual Toxicity Index of Mixture;

[0071] S——LC of standard acaricide 50 , the unit is milligrams per liter (mg / L);

[0072] M——LC of the mixture 50 , the unit is milligrams per liter (mg / L).

[0073] TTI=TI A *P A +TI B *P B

[0074] Where:

[0075] TTI——Theoretical Toxicity Index of Mixtures,

[0076] TI A ——A drug toxicity index, P A ——The percentage of agent A in the mixture, in percentage (%);

[0077] TI B ——Toxicity index of agent B, P B ——The percentage of agent B in the mixture, in percentage (%).

[0078]

[0079] Where:

[0080] CTC – Co-toxicity coefficient;

[0081] ATI——Actual Toxicity Index of Mixture;

[0082] TTI - Theoretical Toxicity Index of Mixture.

[0083] Indoor test results:

[0084] It can be seen from Table 1 that a single agent of fenvalerate showed a higher toxicity to Panonychus citri, while a single agent of flubendiamide had a low toxicity to Panonychus citri.

[0085] The mass ratio of flubendiamide to fenpropiamide in the range of 1:45 to 50:1 showed no antagonistic effect on Panonychus citri; among them, the co-toxicity coefficient of flubendiamide to fenpropiamide in the range of 1:30 to 25:1 was greater than 120, showing a synergistic effect, and the co-toxicity coefficient of flubendiamide to fenpropiamide in the range of 1:17 to 35:1 was greater than 130, showing an obvious synergistic effect.

[0086] Table 1 Determination of the combined toxicity of flubendiamide and fenvalerate at different ratios against nymphs of Panonychus citri

[0087]

[0088] Preparation Example

[0089] Preparation Example 1

[0090] 40% flufenoxuron·fenpyraclostrobin wettable powder (15:25)

[0091] Recipe composition:

[0092] Flufenoxuron - 15%;

[0093] Fenpyraclostrobin - 25%;

[0094] Sodium dodecylbenzenesulfonate - 10%;

[0095] Phenethylphenol polyether phosphate salt - 5.4%;

[0096] Polycarboxylates - 4.5%;

[0097] Starch - 8%;

[0098] White carbon black - 4%;

[0099] Kaolin--make up the balance;

[0100] Preparation method:

[0101] According to the formula ratio of the embodiment, the active ingredients are added to the carrier, and the surfactant and other functional additives are added thereto, mixed, and then air flow pulverized and mixed again to obtain a wettable powder product.

[0102] Preparation Example 2

[0103] 21% Flufenoxuron·Toxafenamide SC (6:15)

[0104] Recipe composition:

[0105] Flufenoxuron - 6%;

[0106] Fenpyraclostrobin - 15%;

[0107] Isotridecyl alcohol polyoxyethylene ether--5%;

[0108] Polycarboxylates - 1.2%;

[0109] Benzoic acid - 1.2%;

[0110] Xanthan gum – 0.1%;

[0111] Magnesium aluminum silicate - 1%;

[0112] Ethylene glycol--5%;

[0113] Dimethicone - 0.4%;

[0114] Deionized water--make up the balance;

[0115] Preparation method: according to the formula ratio of the embodiment, the active ingredients, surfactants and other functional additives are placed in a reaction kettle in sequence, oil is added and mixed evenly, and the suspension product is obtained by high-speed shearing, wet sand grinding, and finally homogenization filtration.

[0116] Preparation Example 3

[0117] 8% Flufenoxuron·Toxafenamide EC (3.5:4.5)

[0118] Recipe composition:

[0119] Flufenoxuron - 3.5%;

[0120] Fenpyraclostrobin - 4.5%;

[0121] Propylene carbonate--5%;

[0122] Calcium dodecylbenzenesulfonate - 3.5%;

[0123] Corn oil – 6%;

[0124] Fatty alcohol polyoxyethylene ether--15%;

[0125] Methyl oleate--make up the balance;

[0126] Preparation method:

[0127] According to the formula ratio of the embodiment, the active ingredients are added into the carrier, and the surfactant and other functional additives are added thereto, and the mixture is stirred and mixed evenly in a stirring mixing kettle to obtain an emulsifiable concentrate product.

[0128] Preparation Example 4

[0129] 38% Flufenoxuron·Toxafenamide water dispersible granules (20:18)

[0130] Recipe composition:

[0131] Flufenoxuron - 20%;

[0132] Fenpyrad--18%;

[0133] Styrene phenol polyoxyethylene ether sulfate sodium salt - 10%;

[0134] Polycarboxylic acid sodium salt - 5%;

[0135] Calcium dodecylbenzenesulfonate - 4%;

[0136] Light calcium carbonate--make up the balance;

[0137] Preparation method:

[0138] According to the formula ratio of the embodiment, the active ingredient is added to the carrier, and the surfactant and other functional hosts are added thereto, mixed, and after air flow pulverization, 10-25% of water is added, and then kneading, granulation, drying and sieving are performed to obtain a water-dispersible granule product.

[0139] Example 2 Field Trial Control of Citrus Red Mite

[0140] Test crops: citrus trees, varieties: sugar orange;

[0141] Test subjects: Citrus spider mite;

[0142] Test location: Longping Town, Lianzhou City, Guangdong Province;

[0143] Experimental field conditions: The orchard is flat, with loam soil and a pH value of 6.0. The soil fertility is medium, the growth is uniform, and the fertilizer and water management levels are consistent.

[0144] Test drug and dosage:

[0145] Table 2 Different tested drugs and dosage

[0146]

[0147] Experimental treatment: Each plot was arranged in random blocks, with 2 trees per plot and repeated 4 times.

[0148] Test time: The pesticide was applied on April 15, 2022. Only one application was performed during the entire test process.

[0149] The weather was good on the day and during the test. On the test day, the average daily temperature was 17°C, the highest temperature was 24°C, the lowest temperature was 15°C, and the relative humidity was 80%.

[0150] Application tools: Use the Hemei HM-16A backpack electric sprayer, and spray both the front and back sides of the leaves during application.

[0151] Application method: The average spray volume for each tree is 2L / tree. During the test, the blank control area is sprayed with an equal amount of clean water first. For the same agent, the treatment is carried out from low dose to high dose in sequence. The sprayer must be washed with clean water before applying the agent between different agent treatments.

[0152] Survey method: Investigate the base number of mites before applying the pesticide, and investigate the number of live mites 1 day and 10 days after applying the pesticide, for a total of 3 surveys.

[0153] For each citrus tree, the upper, middle and lower three leaves were randomly selected from the east, south, west, north and center, and the front and back of the leaves were directly observed with a handheld magnifying glass. In each plot, the number of active red spider mites on 30 leaves of two citrus trees was investigated, and the insect population reduction rate and control effect were calculated.

[0154] The efficacy is calculated as follows:

[0155]

[0156] During the experiment, the citrus trees in each treatment plot grew well and no phytotoxicity was observed in any treatment.

[0157] Test results:

[0158] According to the field investigation, no adverse reactions to the pesticide were found in leaves or twigs under any treatment, indicating that all treatments were safe for citrus growth at the concentrations used in the experiment.

[0159] From the field test results of different tested agents on citrus red spider mites in Tables 3 and 4, it can be seen that the acaricide composition obtained by combining flubendiamide and fenvalerate has a good quick-acting effect on citrus red spider mites.

[0160] One day after application, the control effect of 21% flufenoxuron·fenpyrafenib suspension (6:15) at dilutions of 3000, 4000, and 5000 times on citrus red spider mites was above 80%, significantly higher than that of the control agents; 10 days after application, the control effect of each compound group increased, and the control effect was greater than 90%, showing good persistence, significantly higher than that of the control agents. 21% flufenoxuron·fenpyrafenib suspension (6:15) has a certain quick effect and good persistence on citrus red spider mites, and can be promoted and applied as a pesticide for controlling citrus red spider mites.

[0161] Table 3 Test results of different tested pesticides on citrus red spider mites

[0162]

[0163] Note: The protective effect (%) is the average of each replicate. Lowercase letters represent significant differences at the 5% level, and uppercase letters represent significant differences at the 1% level.

[0164] Table 4 Field test results of different tested pesticides on citrus red spider mites

[0165]

[0166] Note: The protective effect (%) is the average of each replicate. Lowercase letters represent significant differences at the 5% level, and uppercase letters represent significant differences at the 1% level.

[0167] Through indoor toxicity determination and tests on citrus in the field, the acaricidal composition prepared by mixing flufenoxuron with fenpyroximate of the present invention showed good control effect on phytophagous mites.

[0168] The compounded acaricidal composition or the preparation thereof of the present invention has significant control effect, and is superior to a single agent in delaying the generation of drug resistance and prolonging drug retention. In addition, no compound agent was found to cause phytotoxicity to crops in the test, indicating that the acaricidal synergistic efficiencies of the obtained acaricidal composition or preparation are improved, and the production cost and use cost can be reduced, and the acaricidal synergy is safe for crops.

[0169] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0170] The above-mentioned embodiments only express several embodiments of the present application, and the description is relatively specific and detailed, but it cannot be understood as limiting the scope of the invention patent. It should be pointed out that for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present application, which all belong to the protection scope of the present application.

Claims

1. A miticide composition containing flubendiamide, characterized in that: The active ingredients of the acaricide composition include active ingredient A and active ingredient B, wherein the active ingredient A is flufenoxuron and the active ingredient B is fenpyroximate.

2. The acaricidal composition according to claim 1, characterized in that The mass ratio of the active ingredient A to the active ingredient B is 1:45 to 50:

1.

3. The acaricidal composition according to claim 1, characterized in that: The mass ratio of the active ingredient A to the active ingredient B is 1:45 to 35:1; Preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:30 to 25:

1.

4. The acaricidal composition according to claim 1, characterized in that: Based on the total weight of the acaricidal composition being 100 wt%, the sum of the contents of the active ingredient A and the active ingredient B in the acaricidal composition is 1 to 95 wt%; Preferably, the total content of the active ingredient A and the active ingredient B in the acaricidal composition is 5 to 80 wt %.

5. The acaricidal composition according to claim 1, characterized in that: The acaricide composition includes, in addition to effective ingredients, auxiliary ingredients acceptable to agricultural producers.

6. The acaricidal composition according to claim 5, characterized in that: The auxiliary components are selected from one or more of wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, preservatives, stabilizers, synergists, carriers or fillers.

7. The acaricidal composition according to claim 6, characterized in that: The acaricidal composition can be prepared into a formulation form permitted in agriculture, and the formulation form is selected from a solid formulation and / or a liquid formulation.

8. Use of the acaricidal composition according to any one of claims 1 to 7 for controlling phytophagous pest mites.

9. The use according to claim 8, characterized in that The herbivorous mites are Tetranychus, Acaridae and / or Eupodidae. Preferably, the phytophagous pest mite is Panonychus citri, Tetranychus cinnabarinus or Tetranychus urticae.

10. The use according to claim 7, characterized in that The acaricidal composition is applied at an effective dose to the harmful mites to be controlled or the medium where they grow.

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