Shenqi schisandra chinensis capsule as well as preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a ginseng, astragalus and schisandra chinensis capsule as well as a preparation method and application thereof. The radix codonopsis, radix astragali and fructus schizandrae capsule is prepared from the following raw materials in parts by mass: 100 to 150 parts of radix codonopsis, 40 to 80 parts of radix astragali, 150 to 200 parts of fructus schizandrae, 20 to 40 parts of fried semen ziziphi spinosae, 10 to 20 parts of xylaria nigripes powder, 2 to 4 parts of flos albiziae, 2 to 4 parts of herba euphorbiae and 20 to 30 parts of starch. The radix ginseng, radix astragali and fructus schizandrae capsule and the preparation method and application thereof have a more excellent anxiety and insomnia improving effect and take effect faster.

Description

Technical Field

[0001] The present application relates to the technical field of Chinese medicine preparations, and more specifically, to a ginseng, astragalus and schisandra chinensis capsule and a preparation method and application thereof. Background Art

[0002] With the accelerated pace of life, increased work pressure and intensified social competition, more and more people are facing anxiety, which in turn leads to sleep disorders. There is a complex two-way relationship between anxiety and insomnia. Anxiety may cause insomnia, and long-term lack of sleep will further aggravate anxiety, forming a vicious cycle. This cycle not only poses a serious threat to the individual's physical and mental health, but may also lead to reduced work efficiency, deterioration of interpersonal relationships, and even increase the risk of chronic diseases.

[0003] Shenqi Wuweizi Capsule is a Chinese patent medicine preparation that can nourish qi and blood, calm nerves and help sleep. Its formula is based on traditional Chinese medicine theory and is refined in combination with modern pharmaceutical technology. The main ingredients of Shenqi Wuweizi Capsule include Codonopsis pilosula, Astragalus membranaceus, Schisandra chinensis and stir-fried Ziziphus jujuba seeds. Among them, Schisandra chinensis has the functions of astringency, invigorating qi and promoting fluid production, and calming the mind, thus helping to improve sleep quality and relieve symptoms of anxiety and insomnia. However, Shenqi Wuweizi Capsule takes a long time to take effect in improving anxiety and insomnia, and the effect is insufficient, so there is still room for improvement. Summary of the invention

[0004] In order to improve the defect that the conventional Shenqi Schisandrae Chinensis Capsules are not sufficiently effective in treating anxiety and insomnia, the present application provides a Shenqi Schisandrae Chinensis Capsules and a preparation method and application thereof.

[0005] In the first aspect, the present application provides a Shenqi Schisandrae Chinensis Capsule, which adopts the following technical solution: A ginseng, astragalus and schisandra capsule comprises the following raw materials in parts by mass: 100-150 parts of codonopsis pilosula, 40-80 parts of astragalus, 150-200 parts of schisandra, 20-40 parts of stir-fried spiny jujube seeds, 10-20 parts of wuling mushroom powder, 2-4 parts of julibrissin flowers, 2-4 parts of radix schisandrae and 20-30 parts of starch.

[0006] Wuling mushroom powder is rich in polysaccharides, adenosine, sterols and trace elements such as zinc and iron. It has the effects of calming the nerves, enhancing immunity, anti-fatigue and anti-oxidation; Albizia julibrissin flowers and even more are rich in flavonoids and saponins active ingredients. The above active ingredients can affect the level of neurotransmitters in the central nervous system, thereby achieving the effect of calming the nerves and relieving depression, and has a significant effect on improving insomnia, anxiety and depression.

[0007] Therefore, when Wulingjun Powder, Albizzia julibrissin and Radix Atractylodes are used together and added to Shenqi Schisandrae Chinensis Capsules, Wulingjun Powder, Albizzia julibrissin and Radix Atractylodes Chinensis can provide calming and depression-relieving effects from different aspects, thereby effectively enhancing the effect of Shenqi Schisandrae Chinensis Capsules in improving anxiety and insomnia, and accelerating its onset of effect.

[0008] In a second aspect, the present application provides a method for preparing Shenqi Schisandrae Chinensis Capsules, using the following technical solution: A method for preparing ginseng, astragalus and schisandra chinensis capsules comprises the following steps: Raw material pretreatment: mix codonopsis pilosula, astragalus, schisandra chinensis, stir-fried spiny jujube seeds, julibrissin flowers and radix spatholobi, then wash with deionized water, filter and dry, grind and sieve through 50-100 mesh, then add wuling fungus powder and starch, mix thoroughly to obtain raw material powder; Enzymolysis: adding deionized water and compound enzyme to the raw material powder for enzymolysis, wherein the amount of deionized water added is 50-70wt% of the total mass of the raw material powder, the amount of compound enzyme added is 0.4-0.8wt% of the total mass of the raw material powder, the enzymolysis pH value is between 3-5, the enzymolysis temperature is between 40-60°C, the enzymolysis time is between 3-5h, and finally an enzymolysis solution is obtained; Extraction: Add the composite extractant to the enzymatic hydrolyzate, stir for 20-30 minutes, then perform microwave extraction, and finally filter and separate to obtain filtrate 1 and filter residue; then place the filter residue in an expansion solvent, pressurize it to 5-6MPa, stir and extract at room temperature for 30-40 minutes, reduce the pressure to normal pressure and filter again to obtain filtrate 2, and then mix filtrate 1 with filtrate 2 to obtain an extract; Separation and purification: vacuum concentrate the extract, add petroleum ether until dissolved, pass through silica gel column chromatography, and then elute with petroleum ether-ethyl acetate, the volume ratio of petroleum ether to ethyl acetate is (2-4):1, collect the eluate, evaporate to remove the solvent, dry and then grind to obtain Shenqi Schisandrae Chinensis fine powder; Capsule preparation: 35-45g of ginseng, astragalus and schisandra chinensis fine powder is mixed with 30-40g of ethanol, and the mixture is passed through a 20-mesh sieve to form wet granules, which are then placed in capsules after drying to obtain ginseng, astragalus and schisandra chinensis capsules.

[0009] Preferably, the complex enzyme is a mixture of cellulase and pectinase, and the mass ratio of cellulase to pectinase is 1:(3-5).

[0010] The active ingredients in Shenqi Schisandra Capsules used to improve anxiety and insomnia are mainly lignans, which usually coexist with resinous substances. Pectinase can effectively degrade resinous substances, while cellulase can degrade cellulose in the raw materials, thereby effectively improving the extraction effect of lignans and indirectly improving the therapeutic effect of Shenqi Schisandra Capsules on anxiety and insomnia.

[0011] Preferably, the composite extractant is a mixture of 1-butyl-2,3-dimethylimidazolium chloride, diethylene glycol dimethyl ether and hexadecyltrimethylammonium bromide, and the mass ratio of 1-butyl-2,3-dimethylimidazolium chloride, diethylene glycol dimethyl ether and hexadecyltrimethylammonium bromide is 1:(2-4):(0.02-0.06).

[0012] Preferably, the expansion solvent is a mixture of ethanol and CO2, and the volume ratio of ethanol to CO2 is (2-4): (6-8). The amount of the expansion solvent used is 2-4 ml / g based on the filter residue.

[0013] In the composite extractant, 1-butyl-2,3-dimethylimidazole chloride is used as the main extraction solvent, diethylene glycol dimethyl ether is used to promote the matching of effective active substances and holes between solvent molecules, while reducing the solvent viscosity, effectively improving the dispersion ability of the material and the solvent, and hexadecyltrimethylammonium bromide is used to dissolve cell membranes, release active molecules, and promote the separation or transfer of effective active substances in the system. That is, when the composite extractant is used to extract the enzymatic hydrolyzate, the prepared ginseng, astragalus and schisandra chinensis fine powder will contain a higher concentration of effective active substances, thereby further enhancing the therapeutic effect of ginseng, astragalus and schisandra chinensis capsules on anxiety and insomnia.

[0014] Preferably, the raw materials are continuously stirred by an automatic stirrer during the enzymatic hydrolysis process; The automatic mixer includes a water bath, a material barrel transversely fixed in the water bath, and a driving member fixedly connected to the water bath, the material barrel includes a material sleeve and end covers rotatably connected to both ends of the material sleeve, the end covers are fixedly connected to the water bath, and a through hole communicating with the material barrel is penetrated through the edge of the end cover, and the driving member drives the material sleeve to roll in the water bath.

[0015] Preferably, the inner wall of the material sleeve is provided with stirring teeth 1 and stirring teeth 2, and the stirring teeth 1 and the stirring teeth 2 are arranged alternately.

[0016] Preferably, the driving member includes a connecting plate, a driving motor, a driving gear and a driven gear, the connecting plate is fixedly connected to the water bath, the driving motor is fixedly connected to the connecting plate, the driving gear is fixedly connected to the output end of the driving motor, the driven gear is fixedly connected to the outer peripheral surface of the material sleeve, and the driving gear and the driven gear are meshed with each other.

[0017] During the enzymatic hydrolysis process, the contact effect between the enzyme and the substrate, the temperature of the enzymatic hydrolysis, the precipitation of the substrate and the gas exchange are all extremely important. Therefore, in order to obtain better contact between the enzyme and the substrate, the material usually needs to be continuously stirred during the enzymatic hydrolysis process. At present, conventional vertical mixers are usually used for stirring, but the stirring point of the mixer is fixed, and it is difficult to mix the bottom material with the top material. Moreover, under water bath conditions, the temperature is also difficult to transfer to the inside of the material, resulting in insufficient enzymatic hydrolysis effect, which indirectly leads to the insufficient effect of Shenqi Schisandra Capsule in improving anxiety and insomnia, and the effect is slow.

[0018] In the automatic mixer of the present application, the material barrel is fixed horizontally in the water bath. Therefore, when the driving motor drives the material sleeve to rotate, the top and bottom positions and the inner and outer positions of the material sleeve will continue to switch freely under the action of gravity, thereby effectively improving the temperature uniformity of the material and improving the sedimentation condition.

[0019] At the same time, oxygen exchange is also extremely important in the enzymatic hydrolysis process, but if the material barrel is directly perforated, the material will easily flow out of the hole during the rotation of the material barrel. In the present application, the end cover of the material barrel is fixedly connected to the water bath, and the material sleeve is rotatably connected to the end cover, and the through hole is opened at the edge of the end cover, so that when the material is stirred, the through hole will always be in a high position, that is, the material cannot flow out of the through hole when the material sleeve rotates.

[0020] In order to further improve the stirring effect of the material sleeve, in the present application, stirring tooth 1 and stirring tooth 2 are set on the inner wall of the material sleeve, and stirring tooth 1 and stirring tooth 2 are staggered, so that the material is continuously staggered and divided by stirring tooth 1 and stirring tooth 2, thereby effectively improving the dispersion effect of the material.

[0021] In a third aspect, the present application provides an application of Shenqi Schisandrae Chinensis Capsules, which adopts the following technical solution: An application of a ginseng, astragalus and schisandra capsule, wherein the ginseng, astragalus and schisandra capsule is used for improving insomnia, dreaminess, anxiety and depression.

[0022] In summary, this application has the following beneficial effects: 1. Wulingjun powder is rich in polysaccharides, adenosine, sterols and trace elements such as zinc and iron. It has the effects of calming the nerves, enhancing immunity, anti-fatigue and anti-oxidation; Albizia julibrissin and Radix Atractylodes are rich in flavonoids and saponins active ingredients. The above active ingredients can affect the neurotransmitter level of the central nervous system, thereby achieving the effect of calming the nerves and relieving depression, and have a significant effect on improving insomnia, anxiety and depression. Therefore, when Wulingjun powder, Albizia julibrissin and Radix Atractylodes are used together and added to Shenqi Schisandrae Chinensis Capsules, Wulingjun powder, Albizia julibrissin and Radix Atractylodes can provide the effect of calming the nerves and relieving depression from different aspects, thereby effectively enhancing the effect of Shenqi Schisandrae Chinensis Capsules on improving anxiety and insomnia, and accelerating its onset of effect.

[0023] 2. The active ingredients in Shenqi Schisandra Capsules used to improve anxiety and insomnia are mainly lignans, which usually coexist with resinous substances. Pectinase can effectively degrade resinous substances, while cellulase can degrade cellulose in the raw materials, thereby effectively improving the extraction effect of lignans and indirectly improving the therapeutic effect of Shenqi Schisandra Capsules on anxiety and insomnia.

[0024] 3. In the composite extractant, 1-butyl-2,3-dimethylimidazole chloride is used as the main extraction solvent, diethylene glycol dimethyl ether is used to promote the matching of effective active substances and the holes between solvent molecules, while reducing the viscosity of the solvent, effectively improving the dispersion ability of the material and the solvent, and hexadecyltrimethylammonium bromide is used to dissolve cell membranes, release active molecules, and promote the separation or transfer of effective active substances in the system. That is, when the composite extractant is used to extract the enzymatic hydrolyzate, the prepared ginseng, astragalus and schisandra chinensis fine powder will contain a higher concentration of effective active substances, thereby further enhancing the therapeutic effect of ginseng, astragalus and schisandra chinensis capsules on anxiety and insomnia. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a structural diagram of an automatic mixer.

[0026] Figure 2 It is an exploded diagram of the material barrel.

[0027] Figure numerals: 1, water bath; 2, material cylinder; 3, driving member; 21, material sleeve; 22, end cover; 23, through hole; 31, connecting plate; 32, driving motor; 33, driving gear; 34, driven gear; 211, stirring tooth one; 212, stirring tooth two. DETAILED DESCRIPTION

[0028] The following is combined with Figure 1-2 The present application is further described in detail with reference to Examples and Comparative Example 1.

[0029] raw material Codonopsis pilosula, astragalus, schisandra chinensis, spiny jujube seed, urinary tract infection powder, julibrissin flower, radix schisandrae and corn starch are all commercially available; petroleum ether CAS: 8032-32-4; ​​ethyl acetate CAS: 141-78-6; ethanol CAS: 64-17-5; cellulase source leaf S10041; pectinase source leaf S10007; 1-butyl-2,3-dimethylimidazole chloride CAS: 98892-75-2; diethylene glycol dimethyl ether CAS: 111-96-6; hexadecyltrimethylammonium bromide CAS: 57-09-0.

[0030] Example 1 A ginseng, astragalus and schisandra capsule comprises the following raw materials: 130g of codonopsis pilosula, 63g of astragalus, 175g of schisandra chinensis, 28g of stir-fried spiny jujube seeds, 16g of oxalis powder, 3g of julibrissin flower, 3g of radix schisandrae and 24g of starch. The ginseng, astragalus and schisandra capsule is used to improve insomnia, dreaminess, anxiety, depression and other symptoms.

[0031] A method for preparing ginseng, astragalus and schisandra chinensis capsules comprises the following steps: Raw material pretreatment: mix codonopsis pilosula, astragalus, schisandra chinensis, stir-fried spiny jujube seeds, julibrissin flowers and radix schisandrae, then wash with deionized water, filter and dry, grind and pass through a 100-mesh sieve, then add wuling fungus powder and starch, mix thoroughly to obtain raw material powder; Enzymolysis: deionized water and compound enzyme were added to the raw material powder for enzymolysis, the amount of deionized water added was 60wt% of the total mass of the raw material powder, the amount of compound enzyme added was 0.6wt% of the total mass of the raw material powder, the enzymolysis pH value was 4, the enzymolysis temperature was 50°C, the enzymolysis time was 4h, and finally an enzymolysis solution was obtained; The complex enzyme is a mixture of cellulase and pectinase, and the mass ratio of cellulase to pectinase is 1:4; Extraction: Add the composite extractant to the enzymatic hydrolyzate, stir for 30 minutes, and then perform microwave extraction. The microwave parameters are microwave 400W, time 10 minutes, and finally filter and separate to obtain filtrate 1 and filter residue; then place the filter residue in an expansion solvent, pressurize it to 5MPa, stir and extract at room temperature for 35 minutes, reduce the pressure to normal pressure and filter again to obtain filtrate 2, and then mix filtrate 1 with filtrate 2 to obtain an extract; The raw materials are continuously stirred during the enzymatic hydrolysis, and a vertical mixer is used for stirring; The composite extractant is a mixture of 1-butyl-2,3-dimethylimidazolium chloride, diethylene glycol dimethyl ether and hexadecyltrimethylammonium bromide, and the mass ratio of 1-butyl-2,3-dimethylimidazolium chloride, diethylene glycol dimethyl ether and hexadecyltrimethylammonium bromide is 1:3:0.04; The expansion solvent is a mixture of ethanol and CO2, and the volume ratio of ethanol to CO2 is 3:7. The amount of the expansion solvent is 3 ml / g based on the filter residue. Separation and purification: the extract was concentrated in vacuo, petroleum ether was added until dissolved, and the extract was chromatographed on a silica gel column, and then eluted with petroleum ether-ethyl acetate, the volume ratio of petroleum ether to ethyl acetate being 3:1, the eluate was collected, the solvent was evaporated, and the extract was crushed after drying to obtain fine powder of Shenqi Schisandrae Chinensis; Capsule preparation: 40 g of ginseng, astragalus and schisandra chinensis fine powder was mixed with 30 g of ethanol, and the mixture was passed through a 20-mesh sieve to form wet granules, which were then placed in capsules after drying to obtain ginseng, astragalus and schisandra chinensis capsules.

[0032] Example 2 The difference from Example 1 is that the composite enzyme was replaced with cellulase in the same amount.

[0033] Example 3 The difference from Example 1 is that the composite enzyme is replaced with pectinase in the same added amount.

[0034] Example 4-Example 5 The difference from Example 1 is that the mass ratios of the components of the complex enzyme are different, as shown in Table 1.

[0035] Table 1 The mass ratio of each component of the complex enzyme in Example 1 and Example 4-Example 5

[0036] Example 6 The difference from Example 1 is that the composite extractant is replaced with ethanol in the same amount.

[0037] Example 7 The difference from Example 1 is that the raw materials are continuously stirred by an automatic stirrer during the enzymatic hydrolysis process.

[0038] Reference Figure 1 and Figure 2 The automatic mixer includes a water bath 1, a material barrel 2 transversely fixed in the water bath 1, and a driving member 3 fixedly connected to the water bath 1. The material barrel 2 includes a material sleeve 21 and end covers 22 rotatably connected to both ends of the material sleeve 21, and the end covers 22 are fixedly connected to the water bath 1. A through hole 23 communicating with the material barrel 2 is formed through the edge of the end cover 22, and the driving member 3 drives the material sleeve 21 to roll in the water bath 1.

[0039] Specifically, the driving member 3 includes a connecting plate 31, a driving motor 32, a driving gear 33 and a driven gear 34. The connecting plate 31 is fixedly connected to the water bath 1, the driving motor 32 is fixedly connected to the connecting plate 31, the driving gear 33 is fixedly connected to the output end of the driving motor 32, and the driven gear 34 is fixedly connected to the outer peripheral surface of the material sleeve 21, and the driving gear 33 and the driven gear 34 are meshed with each other.

[0040] When enzymolysis is required, the staff can first add the raw material powder, deionized water and compound enzyme into the material sleeve 21, then install the end caps 22 at both ends of the material sleeve 21, and then fix the end caps 22 in the water bath 1. Then move the connecting plate 31, when the driving gear 33 and the driven gear 34 are meshed with each other, turn on the driving motor 32, and the driving motor 32 can drive the material sleeve 21 to rotate.

[0041] In addition, in order to further improve the stirring effect of the material sleeve 21, a stirring tooth 211 and a stirring tooth 212 are fixed to the inner wall of the material sleeve 21. The stirring tooth 211 and the stirring tooth 212 are staggered, so that the material is continuously staggered and divided by the stirring tooth 211 and the stirring tooth 212, thereby further improving the dispersion effect of the material.

[0042] It should be noted that in this embodiment, the above-mentioned fixed connection can be selected according to actual conditions by conventional fixed connection methods such as welding, threaded connection, plug-in fixation, etc. The above-mentioned rotation connection can be selected by conventional rotation connection methods such as flange interference fit.

[0043] Comparative Example 1 The difference from Example 1 is that no more Wulingjun powder, Albizzia julibrissinica and Radix Atractylodes are added to the Shenqi Schisandrae Chinensis Capsules.

[0044] Performance testing 1. Insomnia improvement effect test 800 patients with insomnia were enrolled and randomly divided into 8 groups, with half males and half females in each group, aged between 25 and 45 years. They were then fed with the Shenqi Schisandrae Chinensis Capsules of Example 1 to Example 7 and Comparative Example 1, once a night, 4 capsules each time. After six weeks of treatment, the patients who could sleep continuously for more than 6 hours without waking up or waking up only once were recorded, and the improvement rate was calculated.

[0045] The test data are shown in Table 2.

[0046] Table 2 Test data table of Example 1 to Example 7 and Comparative Example 1

[0047] With reference to Example 1 and Comparative Example 1 and in combination with Table 2, it can be seen that the improvement rate of Example 1 is significantly improved compared with that of Comparative Example 1, which indicates that the addition of Wulingjun powder, Albizzia julibrissinica and Far Eastern can significantly improve the insomnia efficacy of Shenqi Schisandra Capsules.

[0048] The reason is that the black fungus powder is rich in polysaccharides, adenosine, sterols, zinc, iron and other trace elements, which have the effects of calming the nerves, enhancing immunity, anti-fatigue and anti-oxidation; the Albizia julibrissin flowers are rich in flavonoids and saponins, which can affect the level of neurotransmitters in the central nervous system, thereby achieving the effect of calming the nerves and relieving depression, and has a significant effect on improving insomnia, anxiety and depression.

[0049] Therefore, when Wulingjun Powder, Albizzia julibrissin and Radix Atractylodes are used together and added to Shenqi Schisandrae Chinensis Capsules, Wulingjun Powder, Albizzia julibrissin and Radix Atractylodes Chinensis can provide calming and depression-relieving effects from different aspects, thereby effectively enhancing the effect of Shenqi Schisandrae Chinensis Capsules in improving anxiety and insomnia, and accelerating its onset of effect.

[0050] With reference to Example 1-Example 3 and in combination with Table 2, it can be seen that, relative to Example 1, the improvement rates of Example 2-Example 3 are significantly decreased, which indicates that, during the enzymatic hydrolysis process, compared with the use of cellulase or pectinase alone, the prepared Shenqi Schisandra Capsules will have a better effect on improving anxiety and insomnia when cellulase and pectinase are used in combination.

[0051] The reason is that the active ingredients in Shenqi Schisandra Capsules used to improve anxiety and insomnia are mainly lignans, which usually coexist with resinous substances. Pectinase can effectively degrade resinous substances, while cellulase can degrade cellulose in the raw materials, thereby effectively improving the extraction effect of lignans and indirectly improving the therapeutic effect of Shenqi Schisandra Capsules on anxiety and insomnia.

[0052] With reference to Example 1 and Example 4-Example 5 and in combination with Table 2, it can be seen that relative to Example 1, the improvement rates of Example 4-Example 5 are slightly decreased, which indicates that when the mass ratio of cellulase and pectinase is adopted in Example 1, the prepared Shenqi Schisandra Capsules will have a better effect of improving anxiety and insomnia.

[0053] With reference to Example 1 and Example 6 and in combination with Table 2, it can be seen that the improvement rate of Example 6 is significantly reduced compared with that of Example 1, which indicates that, compared with ethanol, the composite extractant of the present application will enable the Shenqi Schisandra Capsule to have a better effect in improving anxiety and insomnia.

[0054] The reason is that in the composite extractant, 1-butyl-2,3-dimethylimidazole chloride is used as the main extraction solvent, diethylene glycol dimethyl ether is used to promote the matching of effective active substances and holes between solvent molecules, while reducing the solvent viscosity, effectively improving the dispersion ability of the material and the solvent, and hexadecyltrimethylammonium bromide is used to dissolve cell membranes, release active molecules, and promote the separation or transfer of effective active substances in the system. That is, when the composite extractant is used to extract the enzymatic hydrolyzate, the prepared ginseng, astragalus and schisandra chinensis fine powder will contain a higher concentration of effective active substances, thereby further enhancing the therapeutic effect of ginseng, astragalus and schisandra chinensis capsules on anxiety and insomnia.

[0055] With reference to Example 1 and Example 7 and in combination with Table 2, it can be seen that, relative to Example 1, the improvement rate of Example 7 is significantly improved, which indicates that the use of an automatic mixer during the enzymatic hydrolysis process will enable the Shenqi Schisandra Capsule to have a better effect in improving anxiety and insomnia.

[0056] The reason is that during the enzymatic hydrolysis process, the contact effect between the enzyme and the substrate, the temperature of the enzymatic hydrolysis, the precipitation of the substrate and the gas exchange are all extremely important. Therefore, in order to obtain better contact between the enzyme and the substrate, the material usually needs to be continuously stirred during the enzymatic hydrolysis process. At present, conventional vertical mixers are usually used for stirring, but the stirring point of the mixer is fixed, and it is difficult to mix the bottom material with the top material. Moreover, under water bath conditions, the temperature is also difficult to be transmitted to the inside of the material, resulting in insufficient enzymatic hydrolysis effect, which indirectly leads to the insufficient effect of Shenqi Schisandra Capsule in improving anxiety and insomnia, and the effect is slow.

[0057] In the automatic mixer of the present application, the material barrel is fixed horizontally in the water bath. Therefore, when the driving motor drives the material sleeve to rotate, the top and bottom positions and the inner and outer positions of the material sleeve will continue to switch freely under the action of gravity, thereby effectively improving the temperature uniformity of the material and improving the sedimentation condition.

[0058] At the same time, the exchange of oxygen is also extremely important in the enzymatic hydrolysis process, but if the material barrel is directly perforated, the material will easily flow out of the hole during the rotation of the material barrel. In the present application, the end cover of the material barrel is fixedly connected to the water bath, and the material sleeve is rotatably connected to the end cover, and the through hole is opened at the edge of the end cover, so that when the material is stirred, the through hole will always be located at a high position, that is, the material cannot flow out of the through hole when the material sleeve rotates. In order to further improve the stirring effect of the material sleeve, in the present application, stirring teeth 1 and stirring teeth 2 are set on the inner wall of the material sleeve, and stirring teeth 1 and stirring teeth 2 are staggered, so that the material is continuously staggered and divided by stirring teeth 1 and stirring teeth 2, and the dispersion effect of the material is effectively improved.

[0059] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A Shenqi Schisandrae Chinensis Capsule, characterized in that: The invention comprises the following raw materials in parts by weight: 100-150 parts of codonopsis pilosula, 40-80 parts of astragalus, 150-200 parts of schisandra chinensis, 20-40 parts of stir-fried spiny jujube seeds, 10-20 parts of wuling mushroom powder, 2-4 parts of julibrissin flowers, 2-4 parts of radix schizonepetae and 20-30 parts of starch.

2. A method for preparing the Shenqi Schisandrae Chinensis Capsule according to claim 1, characterized in that: The following steps are involved: Raw material pretreatment: mix codonopsis pilosula, astragalus, schisandra chinensis, stir-fried spiny jujube seeds, julibrissin flowers and farina, then wash with deionized water, filter and dry, grind and sieve through 50-100 mesh, then add wuling fungus powder and starch, mix thoroughly to obtain raw material powder; Enzymolysis: adding deionized water and compound enzyme to the raw material powder for enzymolysis, wherein the amount of deionized water added is 50-70wt% of the total mass of the raw material powder, the amount of compound enzyme added is 0.4-0.8wt% of the total mass of the raw material powder, the enzymolysis pH value is between 3-5, the enzymolysis temperature is between 40-60°C, the enzymolysis time is between 3-5h, and finally an enzymolysis solution is obtained; Extraction: Add the composite extractant to the enzymatic hydrolyzate, stir for 20-30 minutes, then perform microwave extraction, and finally filter and separate to obtain filtrate 1 and filter residue; then place the filter residue in an expansion solvent, pressurize it to 5-6MPa, stir and extract at room temperature for 30-40 minutes, reduce the pressure to normal pressure and filter again to obtain filtrate 2, and then mix filtrate 1 with filtrate 2 to obtain an extract; Separation and purification: vacuum concentrate the extract, add petroleum ether until dissolved, pass through silica gel column chromatography, and then elute with petroleum ether-ethyl acetate, the volume ratio of petroleum ether to ethyl acetate is (2-4):1, collect the eluate, evaporate to remove the solvent, dry and then grind to obtain Shenqi Schisandrae Chinensis fine powder; Capsule preparation: 35-45g of ginseng, astragalus and schisandra chinensis fine powder is mixed with 30-40g of ethanol, and the mixture is passed through a 20-mesh sieve to form wet granules, which are then placed in capsules after drying to obtain ginseng, astragalus and schisandra chinensis capsules.

3. The preparation method of Shenqi Schisandrae Chinensis Capsule according to claim 2, characterized in that: The complex enzyme is a mixture of cellulase and pectinase, and the mass ratio of cellulase to pectinase is 1:(3-5).

4. The preparation method of Shenqi Schisandrae Chinensis Capsule according to claim 2, characterized in that: The composite extractant is a mixture of 1-butyl-2,3-dimethylimidazolium chloride, diethylene glycol dimethyl ether and hexadecyltrimethylammonium bromide, and the mass ratio of 1-butyl-2,3-dimethylimidazolium chloride, diethylene glycol dimethyl ether and hexadecyltrimethylammonium bromide is 1:(2-4):(0.02-0.06).

5. The preparation method of Shenqi Schisandrae Chinensis Capsule according to claim 2, characterized in that: The expansion solvent is a mixture of ethanol and CO2, and the volume ratio of ethanol to CO2 is (2-4): (6-8). Based on the filter residue, the amount of the expansion solvent is 2-4 ml / g.

6. The preparation method of Shenqi Schisandrae Chinensis Capsule according to claim 2, characterized in that: The raw materials are continuously stirred by an automatic mixer during the enzymatic hydrolysis process; The automatic mixer comprises a water bath (1), a material barrel (2) transversely fixed in the water bath (1), and a driving member (3) fixedly connected to the water bath (1); the material barrel (2) comprises a material sleeve (21) and end covers (22) rotatably connected to both ends of the material sleeve (21); the end covers (22) are fixedly connected to the water bath (1); a through hole (23) communicating with the material barrel (2) is formed through the edge of the end cover (22); and the driving member (3) drives the material sleeve (21) to roll in the water bath (1).

7. The method for preparing the Shenqi Schisandrae Chinensis Capsule according to claim 6, characterized in that: The inner wall of the material sleeve (21) is provided with stirring teeth 1 (211) and stirring teeth 2 (212), and the stirring teeth 1 (211) and the stirring teeth 2 (212) are arranged alternately.

8. The method for preparing the Shenqi Schisandrae Chinensis Capsule according to claim 6, characterized in that: The driving member (3) comprises a connecting plate (31), a driving motor (32), a driving gear (33) and a driven gear (34); the connecting plate (31) is fixedly connected to the water bath (1); the driving motor (32) is fixedly connected to the connecting plate (31); the driving gear (33) is fixedly connected to the output end of the driving motor (32); the driven gear (34) is fixedly connected to the outer peripheral surface of the material sleeve (21); and the driving gear (33) and the driven gear (34) are meshed with each other.

9. An application of the Shenqi Schisandrae Chinensis Capsule according to claim 1, characterized in that: The Shenqi Schisandrae Chinensis Capsule is used to improve the symptoms of insomnia, dreaminess, anxiety and depression.

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