Fat-reducing weight-losing anti-inflammatory composition as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a fat-reducing weight-losing anti-inflammatory composition and a preparation method thereof. The fat-reducing weight-reducing anti-inflammatory composition comprises the following raw materials in parts by weight: 3-10 parts of a green tea extract, 8-15 parts of a green coffee extract, 1-8 parts of a ginseng extract and 26-34 parts of fish oil microcapsule powder. The composition prepared by the invention has remarkable fat-reducing, weight-losing and anti-inflammatory effects, can also effectively prevent body weight rebound, and has a wide application prospect in the technical field of medicines.

Description

Technical Field

[0001] The present invention belongs to the field of medical technology, and specifically relates to a fat-reducing, weight-reducing and anti-inflammatory composition and a preparation method thereof. Background Art

[0002] Obesity can lead to a higher risk of early death and increase the overall mortality rate. In addition to being associated with a variety of chronic diseases such as diabetes, stroke, coronary artery disease, hypertension, obstructive sleep, apnea, etc., it is even associated with the occurrence of a variety of tumors. Obesity is a multifactorial disease, and its pathogenesis has not yet been fully clarified. Long-term lack of exercise, high stress, and unhealthy lifestyles such as high-calorie diets can cause the whole body to be in a state of chronic low-level inflammation for a long time.

[0003] Excessive obesity can lead to abnormalities in the body's sugar metabolism, lipid metabolism, hormone secretion, etc. Excessive fat may also affect the normal functioning of organs and tissues, thereby having adverse effects on multiple systems throughout the body. Long-term bad eating habits and lack of exercise may lead to fat accumulation in the body, causing obesity. After obesity, inflammatory factors may continue to irritate the body. Among them, the role of white adipose tissue in the occurrence and development of pathological obesity has become a research hotspot in recent years.

[0004] For example, Chinese patent CN111345411A provides an energy drink for women and a preparation method thereof. The energy drink for women includes the following components by weight: 0.01-2 parts of amino acids, 1-5 parts of plant extracts, 0.1-2 parts of fruit powder, 0.3-1.5 parts of food flavors, 30-100 parts of non-nutritive sweeteners, 2-4 parts of acidity regulators and 885-996 parts of water. The invention also provides a preparation method for the above-mentioned energy drink for women. The invention is designed specifically for women. While striving to meet women's physical needs, it uses a sugar-free formula and takes into account women's slimming demands. At the same time, it simplifies the preparation process, can quickly prepare energy drinks, and effectively solves the problems of high sugar content, strong irritation and heavy burden on the body. Although the invention discloses green tea extract, green coffee extract and ginseng extract in the specification, the invention does not use fish oil, nor does it combine green tea extract, green coffee extract and ginseng extract, and its application in fat reduction, weight loss and anti-inflammatory is unknown.

[0005] Another example is Chinese patent CN117882864A, which discloses a composition for preventing Alzheimer's disease, and its preparation method and use, belonging to the technical field of functional foods, health foods and pharmaceuticals. The composition of the invention comprises a basic component and a functional component; by weight, the basic component is 50-80 parts of chlorophyll, and the functional component is 2-10 parts, and is composed of saffron extract and spearmint extract, wherein the weight ratio of saffron extract to spearmint extract is 1.2:1-1.8:1; the composition of the invention has the effect of preventing or treating Alzheimer's disease, or delaying the condition of Alzheimer's disease, and can be applied to health foods or functional foods in the future, and also has medicinal potential. Although the invention discloses green coffee extract and fish oil, the invention has not been applied in terms of fat reduction, weight loss and anti-inflammatory effects.

[0006] Therefore, it is urgent to study a safe and effective composition that can reduce fat and weight while having anti-inflammatory effects. Summary of the invention

[0007] Based on the problems existing in the prior art, the present invention provides a composition with fat-reducing, weight-reducing and anti-inflammatory effects, which can significantly reduce the body weight and fat level of mice and has a certain inhibitory effect on inflammatory factors.

[0008] The raw material effects of the present invention are:

[0009] Green tea extract is an active ingredient extracted from green tea leaves, mainly including tea polyphenols (catechins), caffeine, aromatic oils, water, minerals, pigments, carbohydrates, proteins, amino acids, vitamins, etc. Tea polyphenols have antioxidant and free radical scavenging effects, significantly reduce serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels in hyperlipidemia, and have the effect of restoring and protecting vascular endothelial function.

[0010] Green coffee extract comes from the seeds of small-fruit coffee, medium-fruit coffee and large-fruit coffee of the Rubiaceae family. Its main component is chlorogenic acid, which has the effects of lowering blood pressure, anti-tumor, kidney-tonifying and anti-oxidation. It can also be used in health foods to make them sweet and delicious.

[0011] Ginseng extracts include ginsenosides, alkaloids, phenols, phytosterols, carbohydrates, peptides, ginseng oil, amino acids, micronutrients and certain enzymes. Ginseng has a wide range of pharmacological effects, can actively fight fatigue, hyperglycemia, obesity and cancer, and has antioxidant, anti-inflammatory and anti-aging properties. Long-term use can prolong life, enhance physical strength, treat cancer patients with immunodeficiency caused by radiotherapy and chemotherapy, and has anti-cold and heat stress effects. At the same time, it has the effects of enhancing the vitality of human surface cells and inhibiting aging.

[0012] Fish oil is a kind of oil extracted from fatty fish. It is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA, commonly known as brain gold) and various n-3 polyunsaturated fatty acids, and has the effect of lowering triglycerides.

[0013] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0014] Firstly, the present invention provides a fat-reducing, weight-reducing and anti-inflammatory composition, comprising the following raw materials: green tea extract, green coffee extract, ginseng extract and fish oil microcapsule powder.

[0015] Preferably, the fat-reducing, weight-reducing and anti-inflammatory composition comprises the following raw materials, by weight: 3-10 parts of green tea extract, 8-15 parts of green coffee extract, 1-8 parts of ginseng extract and 26-34 parts of fish oil microcapsule powder.

[0016] More preferably, the fat-reducing, weight-reducing and anti-inflammatory composition comprises the following raw materials, by weight: 5-8 parts of green tea extract, 10-13 parts of green coffee extract, 3-6 parts of ginseng extract and 28-31 parts of fish oil microcapsule powder.

[0017] Further preferably, the fat-reducing, weight-reducing and anti-inflammatory composition comprises the following raw materials, by weight: 6 parts of green tea extract, 12 parts of green coffee extract, 4 parts of ginseng extract and 30 parts of fish oil microcapsule powder.

[0018] Preferably, the mass ratio of the green tea extract, the green coffee extract and the ginseng extract is: 3-10:8-15:1-8.

[0019] More preferably, the mass ratio of the green tea extract, the green coffee extract and the ginseng extract is: 5-8:10-13:3-6.

[0020] Further preferably, the mass ratio of the green tea extract, the green coffee extract and the ginseng extract is 6:12:4.

[0021] Preferably, the mass ratio of the total mass of the green tea extract, the green coffee extract and the ginseng extract to the fish oil microcapsule powder is 12-33:26-34.

[0022] More preferably, the mass ratio of the total mass of the green tea extract, the green coffee extract and the ginseng extract to the fish oil microcapsule powder is 18-27:28-31.

[0023] Further preferably, the mass ratio of the total mass of the green tea extract, the green coffee extract and the ginseng extract to the fish oil microcapsule powder is 22:30.

[0024] The present invention also provides the use of the fat-reducing, weight-reducing and anti-inflammatory composition in the preparation of a fat-reducing and weight-reducing product.

[0025] The present invention also provides the use of the fat-reducing, weight-reducing and anti-inflammatory composition in the preparation of anti-inflammatory products.

[0026] In addition, the present invention also provides a fat-reducing, weight-reducing and anti-inflammatory product, comprising the fat-reducing, weight-reducing and anti-inflammatory composition according to any one of claims 1 to 5.

[0027] Preferably, the dosage form of the product is powder, granule, capsule, tablet, oral solution or pill.

[0028] Preferably, the product further comprises pharmaceutically acceptable excipients.

[0029] Preferably, the pharmaceutically acceptable excipients include one or more of fillers, wetting agents, binders, disintegrants and lubricants.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] (1) The present invention combines green tea, green coffee, ginseng extract and fish oil, which has a significant fat-reducing and weight-reducing effect and can prevent weight rebound;

[0032] (2) The composition of the present invention has a good anti-inflammatory effect while having fat-reducing and weight-reducing effects. DETAILED DESCRIPTION

[0033] The technical scheme of the present invention is clearly and completely described below with specific implementation methods. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present invention. The materials, reagents, etc. used, if not otherwise specified, are reagents and materials available from commercial sources.

[0034]

[0035] Example 1 A fat-reducing, weight-reducing and anti-inflammatory composition

[0036] Including the following ingredients:

[0037] 6 parts green tea extract, 12 parts green coffee extract, 4 parts ginseng extract and 30 parts fish oil microcapsule powder.

[0038] Example 2 A fat-reducing, weight-reducing, anti-inflammatory composition

[0039] Including the following ingredients:

[0040] 3 parts green tea extract, 15 parts green coffee extract, 1 part ginseng extract and 33 parts fish oil microencapsulated powder.

[0041] Example 3 A fat-reducing, weight-reducing, anti-inflammatory composition

[0042] Including the following ingredients:

[0043] 10 parts green tea extract, 8 parts green coffee extract, 8 parts ginseng extract and 26 parts fish oil microcapsule powder.

[0044] Example 4 A fat-reducing, weight-reducing, anti-inflammatory composition

[0045] Including the following ingredients:

[0046] 5 parts green tea extract, 13 parts green coffee extract, 3 parts ginseng extract and 31 parts fish oil microencapsulated powder.

[0047] Example 5 A fat-reducing, weight-reducing, anti-inflammatory composition

[0048] Including the following ingredients:

[0049] 8 parts green tea extract, 10 parts green coffee extract, 6 parts ginseng extract and 28 parts fish oil microcapsule powder.

[0050] Comparative Example 1: A fat-reducing, weight-reducing and anti-inflammatory composition

[0051] Including the following ingredients:

[0052] The 6 parts of green tea extract in Example 1 were replaced by 6 parts of green coffee extract.

[0053] Comparative Example 2: A fat-reducing, weight-reducing and anti-inflammatory composition

[0054] Including the following ingredients:

[0055] The 12 parts of green coffee extract in Example 1 were replaced with 12 parts of green tea extract.

[0056] Comparative Example 3: A fat-reducing, weight-reducing and anti-inflammatory composition

[0057] Including the following ingredients:

[0058] The 4 parts of ginseng extract in Example 1 were replaced by 4 parts of green coffee extract.

[0059] Comparative Example 4: A fat-reducing, weight-reducing and anti-inflammatory composition

[0060] Including the following ingredients:

[0061] The 30 parts of fish oil microcapsule powder in Example 1 were replaced by 30 parts of linseed oil having similar efficacy.

[0062] Comparative Example 5: A fat-reducing, weight-reducing and anti-inflammatory composition

[0063] Including the following ingredients:

[0064] 1 part green tea extract, 21 parts green coffee extract, 15 parts ginseng extract and 15 parts fish oil microencapsulated powder.

[0065] Effect Experiment

[0066] Experimental Animals:

[0067] Six-week-old C57BL / 6J male mice (purchased from Beijing Weitonglihua Experimental Animal Technology Co., Ltd.), weighing 21 g ± 2.20 g, were used and housed in a specific pathogen-free standard facility, with 3 mice per cage.

[0068] Experimental methods:

[0069] The mice without modeling were the blank group and fed with standard feed; the obese mice for modeling were divided into the model group, the embodiment group and the comparative group, with 6 mice in each group. After 12 weeks of feeding with 60% high-fat feed, the body weight of the model group was 20% higher than the average body weight of the blank group mice, indicating that the obesity modeling was successful, and then continued to be fed with high-fat feed for 8 weeks, and the blank group was fed with standard feed throughout the whole process. After the successful obesity modeling, the mice in each group of the embodiment and the comparative example were given feed and different components by gavage (gavage after dissolving with 10mL of normal saline and calculating the dose according to body weight) according to different groups every day, and the intervention lasted for 8 weeks. The weight and food intake of each mouse were recorded twice a week. After the feeding was completed, the body composition of the mice was detected, blood was collected after anesthesia, serum was separated, and changes in IL-1β, IL-6, TNF-α, TG, body weight, and body fat of the mice were detected. The results are shown in Table 1.

[0070] Table 1 Results of body weight, body fat, TG and various inflammatory factors in each group of mice

[0071]

[0072] Note: Compared with the model control group, #P<0.05, ##P<0.01, ###P<0.001, ####P<0.0001; compared with Example 1, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.

[0073] It can be seen from the data in Table 1 that, compared with Comparative Examples 1-5, body weight, body fat percentage, TG and inflammatory factors in Examples 1-5 were significantly reduced, which indicates that there is a positive synergistic interaction between the compositions provided by the present invention, and has significant fat-reducing, weight-reducing and anti-inflammatory effects.

Claims

1. A fat-reducing, weight-reducing and anti-inflammatory composition, characterized in that: The following raw materials are included by weight: 3-10 parts of green tea extract, 8-15 parts of green coffee bean extract, 1-8 parts of ginseng extract and 26-34 parts of fish oil microcapsule powder.

2. The anti-inflammatory composition for reducing fat and weight according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 5-8 parts of green tea extract, 10-13 parts of green coffee extract, 3-6 parts of ginseng extract and 28-31 parts of fish oil microcapsule powder.

3. The anti-inflammatory composition for reducing fat and weight according to claim 1, characterized in that: The mass ratio of the green tea extract, the green coffee extract and the ginseng extract is 3-10:8-15:1-8.

4. The anti-inflammatory composition for reducing fat and weight according to claim 1, characterized in that: The mass ratio of the total mass of the green tea extract, the green coffee extract and the ginseng extract to the fish oil microcapsule powder is 12-33:26-34.

5. The anti-inflammatory composition for reducing fat and weight according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 6 parts of green tea extract, 12 parts of green coffee extract, 4 parts of ginseng extract and 30 parts of fish oil microcapsule powder.

6. Use of the fat-reducing, weight-reducing and anti-inflammatory composition according to any one of claims 1 to 5 in the preparation of a product having the effect of reducing fat and weight.

7. Use of the fat-reducing, weight-reducing and anti-inflammatory composition according to any one of claims 1 to 5 in the preparation of anti-inflammatory products.

8. A fat-reducing, weight-reducing and anti-inflammatory product, characterized in that: The invention comprises the fat-reducing, weight-reducing and anti-inflammatory composition according to any one of claims 1 to 5.

9. The product according to claim 8, characterized in that The dosage form of the product is powder, granule, capsule, tablet, oral liquid or pill.

10. The product according to claim 8, characterized in that The product also includes pharmaceutically acceptable excipients.

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