Atractylodes macrocephala corpus luteum traditional Chinese medicine composition for simplifying artificial cycle sequential therapy of various gynopathy

Abstract

The invention provides a bighead atractylodes rhizome and corpus luteum traditional Chinese medicine composition for simplified artificial cycle sequential therapy for various gynecological diseases, which is prepared by elaborately proportioning the following traditional Chinese medicine raw materials: bran-fried bighead atractylodes rhizome, fried Chinese yam, lotus seed, gordon euryale seed, flatstem milkvetch seed, buckeye, teasel root, eucommia ulmoides and the like, and the weight parts of the raw materials are defined. The preparation method comprises the key steps of raw material pretreatment, decoction extraction, concentration, freeze-drying and the like. In addition, the invention also covers various pharmaceutical preparation forms containing the traditional Chinese medicine composition, such as oral decoction, pills, capsules and granules, and pharmaceutically acceptable auxiliary materials can be added into the preparations. Particularly, the composition can be prepared into decoction and can be used by dissolving medicine powder in water. The traditional Chinese medicine composition has a remarkable curative effect in the aspects of treating infertility, irregular menstruation or dysmenorrhea and the like, and has a wide application prospect.

Description

Technical Field

[0001] The invention belongs to the field of gynecological medicines, and specifically discloses a group of Atractylodes macrocephala lutea traditional Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases. Background Art

[0002] In the field of gynecological treatment, Chinese medicine has been favored by patients and doctors for its unique theoretical system and rich clinical experience. In clinical practice, Chinese medicine usually uses Chinese medicine prescriptions for conditioning and treatment of common gynecological diseases such as infertility, irregular menstruation, and dysmenorrhea. However, there are some obvious deficiencies and limitations in the existing Chinese medicine prescription treatment.

[0003] When traditional Chinese medicine is used to treat gynecological diseases, the prescription is often complicated. TCM theory emphasizes the treatment based on syndrome differentiation, that is, carefully selecting each medicinal material and determining its dosage and compatibility according to the patient's specific condition, constitution, age and other factors. Although this reflects the personalized treatment concept of TCM, it also increases the complexity and uncertainty of the prescription. Doctors need to have a high level of TCM theory and clinical experience to accurately treat syndrome differentiation and formulate appropriate TCM prescriptions. For patients, complex TCM prescriptions not only increase the difficulty of purchasing and storing medicinal materials, but also increase the complexity and inconvenience of medication.

[0004] In addition, complex Chinese medicine formulas may also lead to cumbersome preparation processes. The decoction and extraction of multiple medicinal materials requires a lot of time and energy, and requires strict operating specifications and condition control to ensure the stability and effectiveness of the drug. This undoubtedly increases the cost and risk of medication for patients. At the same time, the complex preparation process may also affect the efficacy of the drug, because different medicinal materials may interact or interfere with each other during the decoction and extraction process, thereby affecting the treatment effect.

[0005] In addition, although some existing Chinese medicine prescriptions reflect the idea of ​​syndrome differentiation and treatment in TCM to a certain extent, due to the complexity of the prescriptions, they may cause mutual interference or cancellation of drug effects. On the one hand, different medicinal materials may have similar effects, and repeated use may lead to waste or excess of drug effects; on the other hand, different medicinal materials may have mutual antagonism or restriction, affecting the overall drug effect. This not only reduces the efficiency of treatment, but may also increase the burden and risk of medication for patients.

[0006] Therefore, there is an urgent need for a Chinese medicine composition with simple formula, definite efficacy and convenient preparation for the treatment of various gynecological diseases. Summary of the invention

[0007] To solve the above problems, we disclose a group of simplified artificial cycle sequential therapy Atractylodes macrocephala lutea Chinese medicine compositions for various gynecological diseases. The composition is made by selecting several Chinese medicine raw materials with clear medicinal effects, such as bran-fried Atractylodes macrocephala, fried Chinese yam, lotus seeds, Euryale ferox, Astragalus complanatus, Salacia serrata, Dipsacus asper and Eucommia ulmoides, etc., and combining them according to scientific proportions, aiming to overcome the shortcomings of existing Chinese medicines such as complex formulas, cumbersome preparations and unstable efficacy.

[0008] The present invention includes the following specific technical solutions:

[0009] A group of Atractylodes macrocephala and corpus luteum Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases are made from the following Chinese medicine decoction pieces: fried Atractylodes macrocephala with bran, fried yam, lotus seeds, Euryale ferox, Astragalus complanatus seeds, Dipsacus asper, and Eucommia ulmoides.

[0010] Furthermore, the above-mentioned set of Atractylodes macrocephala lutea Chinese medicine composition for simplified artificial cycle sequential therapy of various gynecological diseases is made of the following Chinese medicine decoction pieces raw materials in parts by weight: 10-20 parts of fried Atractylodes macrocephala with bran, 20-40 parts of fried yam, 10-20 parts of lotus seeds, 10-20 parts of Euryale ferox, 10-20 parts of Astragalus membranaceus seeds, 5-15 parts of Smilax glabra seeds, 5-15 parts of Dipsacus asper, and 10-20 parts of Eucommia ulmoides.

[0011] Furthermore, the above-mentioned set of Atractylodes macrocephala and corpus luteum Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases is made of the following Chinese medicine decoction pieces in parts by weight: 15 parts of fried Atractylodes macrocephala with bran, 30 parts of fried yam, 15 parts of lotus seeds, 15 parts of Euryale ferox, 15 parts of Astragalus membranaceus, 10 parts of Salacia scabra seeds, 10 parts of Dipsacus asper, and 15 parts of Eucommia ulmoides.

[0012] The present invention also discloses a method for preparing the above-mentioned Atractylodes macrocephala lutea Chinese medicine composition for simplified artificial cycle sequential therapy of various gynecological diseases, comprising the following steps:

[0013] 1) Weigh the raw materials according to the formula, wash and dry them, and then crush them for later use;

[0014] 2) Put the crushed raw materials into 5-15 times the amount of distilled water, soak for 20-40 minutes, then heat and decoct. The first decoction time is 0.5-1.5 hours, and filter and collect the liquid medicine;

[0015] 3) Add 4-12 times the amount of water for a second decoction for 0.5-1.5 hours, and filter and collect the liquid medicine;

[0016] 4) The two extracts of step 2) and step 3) are combined, concentrated to a drug solution with a concentration of 1 g / mL or more at 50-70° C. using a rotary evaporator, and then freeze-dried to prepare drug powder to obtain the traditional Chinese medicine composition.

[0017] The invention also discloses a pharmaceutical preparation, which contains the above-mentioned Chinese medicine composition or is prepared from the above-mentioned Chinese medicine composition.

[0018] Furthermore, the above-mentioned pharmaceutical preparation has a dosage form including oral decoction, pills, capsules or granules.

[0019] Furthermore, the above-mentioned pharmaceutical preparation also includes pharmaceutically acceptable excipients.

[0020] Furthermore, the above-mentioned pharmaceutical preparation is a decoction, which is prepared by dissolving a therapeutic amount of pharmaceutical powder in water when used.

[0021] The present invention also discloses the use of the above-mentioned Chinese medicine composition in preparing a medicine for treating infertility, irregular menstruation or dysmenorrhea. Preferably, it is suitable for treating infertility, irregular menstruation, dysmenorrhea and other diseases related to the menstrual cycle, and is selected from the period from ovulation to the second day of menstruation when using simplified Chinese medicine artificial cycle sequential therapy.

[0022] Compared with the prior art, the present invention has the following outstanding beneficial effects:

[0023] After ovulation, both yin and yang are at their peak, the endometrium undergoes secretory phase changes under the action of estrogen and progesterone, and the follicle enters the luteal phase.

[0024] The bran-fried white atractylodes in the formula is bitter, sweet and warm in nature, and enters the spleen and stomach meridians, and has the functions of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, and calming the fetus; the fried yam is sweet and neutral in nature, and enters the spleen, lung and kidney meridians, and has the functions of tonifying the spleen and nourishing the stomach, promoting fluid and benefiting the lungs, and tonifying the kidney and astringing the essence; the lotus seeds are sweet and astringent in nature and are neutral in nature, and enter the spleen, kidney and heart meridians, and have the functions of tonifying the spleen and stopping diarrhea, stopping leukorrhea, benefiting the kidney and astringing the essence, and nourishing the heart and calming the mind; the gorgon fruit is sweet and astringent in nature and is neutral in nature, and enters the spleen and kidney meridians, and has the functions of benefiting the kidney and consolidating the essence, tonifying the spleen and stopping It has the functions of purging, removing dampness and stopping leukorrhea. Astragalus membranaceus is sweet and warm in nature. It enters the liver and kidney meridians. It has the functions of tonifying the kidney and assisting yang, consolidating essence and reducing urination, nourishing the liver and improving eyesight. Salacia membranaceus is sweet and warm in nature. It enters the liver and stomach meridians. It has the functions of soothing the liver and regulating qi, harmonizing the stomach and relieving pain. Dipsacus asper has a bitter and pungent taste and is slightly warm in nature. It enters the liver and kidney meridians. It has the functions of tonifying the liver and kidney, strengthening the tendons and bones, treating fractures and stopping metrorrhagia. Eucommia ulmoides is sweet and warm in nature. It enters the liver and kidney meridians. It has the functions of tonifying the liver and kidney, strengthening the tendons and bones, and calming the fetus.

[0025] Fried Atractylodes macrocephala with bran, fried yam, lotus seeds, and Euryale ferox all enter the spleen. All things grow from the earth. Strengthening the spleen and earth can nourish the acquired foundation and the source of biochemistry to facilitate embryo implantation. Astragalus membranaceus, Dipsacus asper, and Eucommia ulmoides enter the liver and kidney. Reproduction is closely related to the kidney's dominance over the innate. Nourishing the liver and kidney and strengthening the tendons and bones are beneficial to consolidating the essence and protecting the fetus. Smilax glabra seeds can soothe the liver and regulate qi. The treatment during this period focuses on nourishing the spleen and kidney, while soothing the liver and regulating qi to improve the corpus luteum function and cause secretory changes in the endometrium. At the same time, attention is paid to protecting the spleen and stomach to make the biochemistry of qi and blood active, to ensure regular menstruation or embryo growth, and to add a small amount of liver-soothing and qi-regulating products to prevent tonics from stagnating the qi mechanism, to maintain the balance of yin and yang and the circulation of qi.

[0026] In summary, the present invention is to combine the Chinese medicinal raw materials with clear efficacy such as bran-fried Atractylodes macrocephala, fried Chinese yam, lotus seed, Euryale ferox, Astragalus complanatus, Salacia chinensis, Dipsacus asper and Eucommia ulmoides into a simplified artificial cycle sequential therapy Atractylodes macrocephala lutea Chinese medicinal composition according to a scientific ratio, effectively overcoming the shortcomings of the existing Chinese medicine prescription being complicated, cumbersome to prepare, and unstable efficacy. The composition is not only simple to prepare, but also has a stable and reliable efficacy, and is particularly suitable for the treatment of various gynecological diseases. The prescription has exquisite compatibility of various medicines, which not only invigorates the spleen and replenishes qi, dries dampness and promotes diuresis to nourish the acquired foundation, but also invigorates the kidney and assists yang, consolidates essence and shrinks urine to consolidate the original and protect the fetus, and simultaneously soothes the liver and regulates qi to maintain the balance of yin and yang. This composition can be made into a variety of dosage forms such as oral decoctions, pills, capsules or granules, which is convenient for patients to use. Compared with the existing technology, the present invention pays more attention to overall conditioning, mainly nourishing the spleen and kidneys, soothing the liver and regulating qi, improving the function of the corpus luteum, improving the state of the endometrium, ensuring regular menstruation or embryo growth, and providing a more comprehensive and effective Chinese medicine treatment plan for the treatment of gynecological diseases, which has broad clinical application prospects and social value. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 Figure 2. Weight changes of experimental rats;

[0028] Figure 2 Figure 3. Weight changes of experimental rabbits. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] Example 1

[0031] A set of Atractylodes macrocephala and corpus luteum Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases are prepared from the following Chinese medicine decoction pieces in parts by weight: 10 parts of fried Atractylodes macrocephala with bran, 20 parts of fried yam, 10 parts of lotus seeds, 10 parts of Euryale ferox, 10 parts of Astragalus membranaceus seeds, 5 parts of Salacia scabra seeds, 5 parts of Dipsacus asper, and 10 parts of Eucommia ulmoides.

[0032] The preparation method of the above-mentioned simplified artificial cycle sequential therapy Atractylodes macrocephala lutea Chinese medicine composition for various gynecological diseases comprises the following steps:

[0033] 1) Weigh the raw materials according to the formula, wash and dry them, and then crush them for later use;

[0034] 2) Put the crushed raw materials into 10 times the amount of distilled water, soak for 30 minutes, then heat and decoct. The first decoction time is 1 hour, and filter and collect the liquid medicine;

[0035] 3) Add 8 times the amount of water for a second decoction for 1 hour, and filter and collect the liquid;

[0036] 4) The two extracts of step 2) and step 3) are combined, concentrated to a 1 g / mL medicinal solution at 60° C. using a rotary evaporator, and then the medicinal solution is freeze-dried to prepare a medicinal powder to obtain the traditional Chinese medicine composition.

[0037] Example 2

[0038] A set of Atractylodes macrocephala and corpus luteum Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases are prepared from the following Chinese medicine decoction pieces in parts by weight: 15 parts of fried Atractylodes macrocephala with bran, 30 parts of fried yam, 15 parts of lotus seeds, 15 parts of Euryale ferox, 15 parts of Astragalus membranaceus seeds, 10 parts of Salacia serrata seeds, 10 parts of Dipsacus asper, and 15 parts of Eucommia ulmoides.

[0039] The preparation method of the above-mentioned simplified artificial cycle sequential therapy Atractylodes macrocephala lutea Chinese medicine composition for various gynecological diseases comprises the following steps:

[0040] 1) Weigh the raw materials according to the formula, wash and dry them, and then crush them for later use;

[0041] 2) Put the crushed raw materials into 10 times the amount of distilled water, soak for 30 minutes, then heat and decoct. The first decoction time is 1 hour, and filter and collect the liquid medicine;

[0042] 3) Add 8 times the amount of water for a second decoction for 1 hour, and filter and collect the liquid;

[0043] 4) The two extracts of step 2) and step 3) are combined, concentrated to a 1 g / mL medicinal solution at 60° C. using a rotary evaporator, and then the medicinal solution is freeze-dried to prepare a medicinal powder to obtain the traditional Chinese medicine composition.

[0044] Example 3

[0045] A set of Atractylodes macrocephala and corpus luteum Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases are prepared from the following Chinese medicine decoction pieces in parts by weight: 20 parts of fried Atractylodes macrocephala with bran, 40 parts of fried yam, 20 parts of lotus seeds, 20 parts of Euryale ferox, 20 parts of Astragalus membranaceus seeds, 15 parts of Salacia serrata seeds, 15 parts of Dipsacus asper, and 20 parts of Eucommia ulmoides.

[0046] The preparation method of the above-mentioned simplified artificial cycle sequential therapy Atractylodes macrocephala lutea Chinese medicine composition for various gynecological diseases comprises the following steps:

[0047] 1) Weigh the raw materials according to the formula, wash and dry them, and then crush them for later use;

[0048] 2) Put the crushed raw materials into 10 times the amount of distilled water, soak for 30 minutes, then heat and decoct. The first decoction time is 1 hour, and filter and collect the liquid medicine;

[0049] 3) Add 8 times the amount of water for a second decoction for 1 hour, and filter and collect the liquid;

[0050] 4) The two extracts of step 2) and step 3) are combined, concentrated to a 1 g / mL medicinal solution at 60° C. using a rotary evaporator, and then the medicinal solution is freeze-dried to prepare a medicinal powder to obtain the traditional Chinese medicine composition.

[0051] Test Example 1

[0052] Rat experiments.

[0053] According to the prescription ratio, the relevant medicinal materials of Atractylodes macrocephala (mixture) soup (i.e., the formula of Example 2) are prepared: 15 grams of bran-fried Atractylodes macrocephala, 30 grams of fried yam, 15 grams of lotus seeds, 15 grams of Euryale ferox, 15 grams of Astragalus, 10 grams of Sala seeds, 10 grams of Dipsacus asper, and 15 grams of Eucommia ulmoides. All medicinal materials must meet the standards of the "Chinese Pharmacopoeia", and are crushed for standby use after cleaning and drying. The above medicinal materials are put into 10 times the amount of distilled water (i.e., 1g of medicinal materials are put into 10mL of water, the same below), soaked for 30 minutes and then heated and decocted. The first decoction time is 1 hour, and the medicinal liquid is filtered and collected; 8 times the amount of water is added for the second decoction, the time is 1 hour, and the medicinal liquid is filtered and collected. The two extracts are combined and concentrated to a 1g / mL medicinal liquid at 60°C using a rotary evaporator. The medicinal liquid is then freeze-dried to prepare a medicinal powder for standby use. The medicinal powder is prepared into an aqueous solution at a dose of 1.5g / kg (rat body weight) for oral administration to rats. Atractylodes replacement: Atractylodes was replaced with Astragalus, and the Atractylodes in the prescription of the Atractylodes-free group was removed, and the preparation method was the same as above.

[0054] Female SD rats were randomly divided into six groups: blank control group, cisplatin control group, motherwort granule group, prescription group, atractylodes macrocephala replacement group, and atractylodes macrocephala removal group. The blank control group was given 3 mL / kg of normal saline, the cisplatin control group was injected with 3 mg / kg of cisplatin, the motherwort granule group was given 1.5 g / kg of motherwort granule aqueous solution, and the prescription group, atractylodes macrocephala replacement group, and atractylodes macrocephala removal group were given 1.5 g / kg of Chinese medicine aqueous solution, respectively. The experimental period included 7 days of intraperitoneal injection of 3 mg / kg cisplatin, 21 days of normal feeding period, 14 days of drug administration period, and 28 days of drug withdrawal observation period. The estrous cycle changes, serum estradiol (E2) and follicle-stimulating hormone (FSH) levels, body weight changes, and coat color changes of the rats were detected in the experiment. The results are shown in Tables 1, 2, and Figure 1 shown.

[0055] Blank control group: E2 about 85pg / mL, FSH about 6ng / mL, mature follicles about 13 / rat, atretic follicles about 2.5 / rat, and reproductive success rate about 90%. Cisplatin control group: E2 about 50pg / mL, FSH about 10ng / mL, mature follicles about 6 / rat, atretic follicles about 6 / rat, and reproductive success rate about 10%. Motherwort granule group: E2 about 60pg / mL, FSH about 7ng / mL, mature follicles about 7 / rat, atretic follicles about 5 / rat, and reproductive success rate about 30%. Prescription group: E2 about 75pg / mL, FSH about 5ng / mL, mature follicles about 12 / rat, atretic follicles about 3 / rat, and reproductive success rate about 80%. Atractylodes macrocephala replacement group: E2 about 65pg / mL, FSH about 7ng / mL, mature follicles about 9 / rat, atretic follicles about 4 / rat, and fertility success rate about 50%. Atractylodes macrocephala removal group: E2 about 60pg / mL, FSH about 8ng / mL, mature follicles about 8 / rat, atretic follicles about 5 / rat, and fertility success rate about 40%.

[0056] Changes in weight and coat color showed that: the cisplatin control group had a significant decrease in weight and the coat color was the worst; the Leonurus granule group had limited weight recovery and a slight improvement in coat color; the prescription group had obvious weight recovery and the coat color and luster improved most significantly; the Atractylodes replacement group and the Atractylodes removal group had better weight recovery, but not as good as the prescription group, and the coat color improvement was limited.

[0057] Table 1 Changes of various physiological indicators of rats

[0058]

[0059]

[0060] Table 2 Body weight changes of rats

[0061]

[0062] From the test items, it can be seen that the treatment effect of the prescription group is significantly better than that of other groups. The effect of the Atractylodes macrocephala replacement group and the Atractylodes macrocephala removal group is relatively weakened, indicating the importance of each ingredient in the overall efficacy. This prescription provides an effective alternative for the treatment of infertility, irregular menstruation, dysmenorrhea and other diseases, and its effect is significantly better than that of the Leonurus granule group.

[0063] Test Example 2

[0064] New Zealand White Rabbit Experiment.

[0065] Select the Baizhuhuangti (mixture) decoction medicinal materials (i.e., the formula of Example 2) that meet the standards of the Chinese Pharmacopoeia, including 15 grams of bran-fried Baizhu, 30 grams of fried yam, 15 grams of lotus seeds, 15 grams of Euryale ferox, 15 grams of Astragalus, 10 grams of Sala seeds, 10 grams of Dipsacus, and 15 grams of Eucommia. The medicinal materials were cleaned, dried, and crushed for standby use. The medicinal materials were added to 10 times the amount of distilled water and decocted in water after soaking for 30 minutes. The first decoction time was 1 hour, and the liquid was filtered; 8 times the amount of water was added for the second decoction, the time was 1 hour, and the liquid was filtered. The two extracts were combined and concentrated to a 1g / mL medicinal solution using a rotary evaporator. The concentrated medicinal solution was dried at 60°C to obtain a medicinal powder. Before the experimental medication, the medicinal powder was prepared into an aqueous solution at a dose of 10g / kg (white rabbit weight) for experimental use. The Baizhu replacement group replaced the Baizhu with Astragalus, and the Baizhu group removed the Baizhu in the prescription, and the preparation method was the same as above.

[0066] Female New Zealand white rabbits were randomly divided into six groups: blank control group, cisplatin control group, motherwort granule group, prescription group, atractylodes macrocephala replacement group, and atractylodes macrocephala removal group. The blank control group received 2 mL / kg normal saline treatment, the cisplatin control group was injected with 2 mg / kg cisplatin but no other drug interventions were performed, the motherwort granule group was given 2 g / kg motherwort granule aqueous solution, and the prescription group, atractylodes macrocephala replacement group, and atractylodes macrocephala removal group were given 10 g / kg Chinese medicine aqueous solution, respectively. The experimental period included 7 days of cisplatin injection, 21 days of normal feeding period, 14 days of drug administration period, and 28 days of drug withdrawal observation period. The estrous cycle changes, serum estradiol (E2) and follicle-stimulating hormone (FSH) levels, body weight changes, and coat color changes of the rabbits were detected in the experiment, as shown in Tables 3, 4, and Figure 2 shown.

[0067] Blank control group: E2 about 90pg / mL, FSH about 5ng / mL, about 14 mature follicles per rabbit, about 1 atretic follicle per rabbit, and a fertility success rate of about 90%. Cisplatin control group: E2 about 45pg / mL, FSH about 11ng / mL, about 4 mature follicles per rabbit, about 8 atretic follicles per rabbit, and a fertility success rate of about 15%. Motherwort granule group: E2 about 55pg / mL, FSH about 8ng / mL, about 7 mature follicles per rabbit, about 6 atretic follicles per rabbit, and a fertility success rate of about 35%. Prescription group: E2 about 80pg / mL, FSH about 6ng / mL, about 11 mature follicles per rabbit, about 2 atretic follicles per rabbit, and a fertility success rate of about 75%. Atractylodes macrocephala replacement group: E2 about 70pg / mL, FSH about 7ng / mL, mature follicles about 9 / rabbit, atretic follicles about 4 / rabbit, and fertility success rate about 60%. Atractylodes macrocephala removal group: E2 about 60pg / mL, FSH about 9ng / mL, mature follicles about 8 / rabbit, atretic follicles about 5 / rabbit, and fertility success rate about 45%.

[0068] The weight of the cisplatin control group decreased significantly, and the coat color was the worst; the weight of the motherwort granule group recovered slightly, and the coat color improved slightly;

[0069] The prescription group recovered significantly in terms of body weight, and the improvement in coat color and luster was the most significant; the Atractylodes macrocephala replacement group and the Atractylodes macrocephala removal group recovered better in terms of body weight, but not as good as the prescription group, and the improvement in coat color was limited.

[0070] Table 3 Changes of various physiological indicators of white rabbits

[0071]

[0072] Table 4 Weight changes of white rabbits

[0073]

[0074] From the above test results, it can be seen that the treatment effect of the prescription group is significantly better than that of other groups. The effect of the Atractylodes macrocephala replacement group and the Atractylodes macrocephala removal group is relatively weakened, indicating the importance of the Atractylodes macrocephala component in the overall efficacy. This prescription provides an effective alternative for the treatment of infertility, irregular menstruation, dysmenorrhea and other diseases.

[0075] The above are only a few preferred embodiments of the present invention, which are described in a more specific and detailed manner, but they cannot be understood as limiting the scope of the present invention. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A group of Atractylodes macrocephala lutea Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases, characterized in that: It is made from the following Chinese medicinal materials: fried Atractylodes macrocephala with bran, fried yam, lotus seeds, Euryale ferox, Astragalus membranaceus, Dipsacus asper, and Eucommia ulmoides.

2. A set of Atractylodes macrocephala lutea Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases according to claim 1, characterized in that: The invention is prepared from the following Chinese medicinal decoction pieces raw materials in parts by weight: 10-20 parts of fried atractylodes macrocephala with bran, 20-40 parts of fried yam, 10-20 parts of lotus seeds, 10-20 parts of euryale seeds, 10-20 parts of astragalus seeds, 5-15 parts of salvia seeds, 5-15 parts of dipsacus root and 10-20 parts of eucommia bark.

3. A set of Atractylodes macrocephala lutea Chinese medicine compositions for simplified artificial cycle sequential therapy of various gynecological diseases according to claim 2, characterized in that: The invention is prepared from the following Chinese medicinal decoction pieces raw materials in parts by weight: 15 parts of fried atractylodes macrocephala with bran, 30 parts of fried yam, 15 parts of lotus seeds, 15 parts of Euryale ferox seeds, 15 parts of Astragalus membranaceus seeds, 10 parts of Salacia serrata seeds, 10 parts of Dipsacus asper and 15 parts of Eucommia ulmoides.

4. The method for preparing the Atractylodes macrocephala lutea Chinese medicine composition for simplified artificial cycle sequential therapy of various gynecological diseases as claimed in any one of claims 1 to 3, characterized in that: The following steps are involved: 1) Weigh the raw materials according to the formula, wash, dry and crush them for later use; 2) Put the crushed raw materials into 5-15 times the amount of distilled water, soak for 20-40 minutes, then heat and decoct. The first decoction time is 0.5-1.5 hours, and filter and collect the liquid medicine; 3) Add 4-12 times the amount of water for a second decoction for 0.5-1.5 hours, and filter and collect the liquid; 4) The two extracts of step 2) and step 3) are combined, and concentrated to a drug solution with a concentration of more than 1 g / mL at 50-70° C. using a rotary evaporator, and then the drug solution is freeze-dried to prepare a drug powder to obtain the traditional Chinese medicine composition.

5. A pharmaceutical preparation, characterized in that Contains the Chinese medicine composition as described in any one of claims 1 to 3, or is made from the above Chinese medicine composition.

6. The pharmaceutical preparation according to claim 5, characterized in that The dosage form of the pharmaceutical preparation includes oral decoction, pills, capsules or granules.

7. The pharmaceutical preparation according to claim 6, characterized in that The preparation also includes pharmaceutically acceptable excipients.

8. The pharmaceutical preparation according to claim 5, characterized in that The preparation is a decoction, which is prepared by dissolving a therapeutic amount of drug powder in water when used.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating infertility, irregular menstruation or dysmenorrhea.

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