Pharmaceutical composition for treating ventricular premature beat as well as preparation method and application thereof

Abstract

The invention discloses a pharmaceutical composition for treating ventricular premature beat. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 9-20 parts of radix adenophorae, 9-20 parts of radix scrophulariae, 9-20 parts of radix salviae miltiorrhizae, 10-20 parts of radix asparagi, 10-20 parts of radix ophiopogonis, 10-30 parts of semen boitae, 10-30 parts of fried jujube kernel, 20-30 parts of nacre mother of pearl, 20-30 parts of dragon bone, 20-30 parts of oyster, 10-20 parts of polygala tenuifolia and 10-20 parts of radix rehmanniae. The preparation method comprises the following steps: mixing all the raw materials according to 1 g / weight part, adding cold water, soaking for 30 minutes, decocting for three times, and taking 450-750 ml of liquid medicine; the traditional Chinese medicine is taken for 2-3 times within one day; boiling with a strong fire and then continuing to decoct with a slow fire in each decoction; the pharmaceutical composition disclosed by the invention can also be added with medically acceptable auxiliary materials to be prepared into capsules, granules, oral liquid, pills and tablets. 'Three ginseng' and'two winter 'are used as monarch drugs; nacre, fossil fragments and oysters are used as ministerial drugs; the assistant and guide drugs comprise polygala tenuifolia and radix rehmanniae; the composition can improve the atrial structure by inhibiting inflammatory response so as to prevent and treat the occurrence and development of ventricular premature beat.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a pharmaceutical composition for treating premature ventricular beats, a preparation method and an application thereof. Background Art

[0002] Premature ventricular contractions (PVCs) are a common heart rhythm abnormality that originates in one of the chambers in the lower part of the heart (ventricles), where the ventricular muscle beats once in advance, before the normal sinus beat. This premature beat disrupts the normal rhythm of the heart, causing an irregular heartbeat.

[0003] Most patients with ventricular premature beats may have no obvious symptoms, especially occasional ventricular premature beats. However, patients with frequent ventricular premature beats may experience symptoms including: momentary panic, palpitations, a feeling of weightlessness or overweight similar to the rapid rise and fall of an elevator; some patients may have a feeling of cardiac arrest or discomfort in the throat; they may also be accompanied by symptoms such as dizziness, headache, chest tightness, and fatigue. Prolonged ventricular premature beats may lead to coronary ischemia and hypoxia, and then symptoms of angina pectoris may occur, such as chest tightness, shortness of breath, difficulty breathing, a squeezing feeling on the sternum, and radiating to the left shoulder and left back. Severe cases may experience symptoms of hypotension, such as blackouts, nausea, vomiting, cold sweats, and even fainting and shock.

[0004] Ventricular premature beats belong to the category of "heart palpitations" in traditional Chinese medicine. Traditional Chinese medicine believes that the occurrence of heart palpitations is caused by deficiency of qi, blood, yin and yang, the heart is not nourished, or evil disturbs the mind, and the mind is restless. The disease is located in the heart, and is closely related to the liver, spleen, kidney and lung. In the early stage of heart palpitations, it is often mainly caused by deficiency of heart qi. Long-term illness causes damage to the heart blood and heart yin, deficiency of yin and blood, and the heart is not nourished, and the mind is restless, then the heart palpitations are uneasy. At this time, if the external evil disturbs the heart, such as water and drink, blood stasis blocking the heart meridian, phlegm and fire, etc., which disturb the heart and make the mind restless, it will definitely aggravate the palpitations under the heart. Therefore, the treatment of heart palpitations is mainly to replenish the deficiency, and to eliminate evil, but never forget the method of calming the mind and tranquilizing the nerves.

[0005] Studies have found that the occurrence and development of ventricular premature beats are closely related to atrial structure, and inflammatory factors affect changes in atrial structure. At present, the drug treatment of ventricular premature beats is not effective with Western medicine, and long-term use of Western medicine will have more side effects. Therefore, there is a great demand for Chinese medicine that can effectively treat ventricular premature beats.

[0006] The advantage of TCM in treating ventricular premature beats is that it has few side effects and a stable and long-lasting effect. TCM emphasizes the holistic concept and syndrome differentiation and treatment, and can provide personalized treatment based on the patient's specific condition and physical characteristics. In addition, the multi-formulation characteristics of TCM preparations give it a multi-point and multi-channel mechanism of action, which can comprehensively regulate heart function.

[0007] Although traditional Chinese medicine has significant advantages in treating ventricular premature beats, it still faces some challenges. For example, the mechanism of action of traditional Chinese medicine has not been fully elucidated, and further basic research and clinical research are needed to clarify its efficacy and safety. In addition, the standardization and quality control of traditional Chinese medicine are also one of the issues that need to be addressed.

[0008] Therefore, it is necessary to provide a pharmaceutical composition for treating ventricular premature beats, which can inhibit inflammatory response, improve atrial structure, and thus prevent and treat ventricular premature beats. Summary of the invention

[0009] In order to solve the above technical problems, one object of the present invention is to provide a pharmaceutical composition for treating ventricular premature beats, which is designed based on the syndrome differentiation and treatment of monarch, minister, assistant and envoy in traditional Chinese medicine, and can inhibit inflammatory response, improve atrial structure, and have a preventive and therapeutic effect on ventricular premature beats.

[0010] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0011] A pharmaceutical composition for treating ventricular premature beats, comprising the following raw materials in parts by weight: 9-20 parts of Adenophora Root, 9-20 parts of Scrophularia Root, 9-20 parts of Salvia Root, 10-20 parts of Asparagus Codonopsis, 10-20 parts of Radix Ophiopogonis, 10-30 parts of Platycladus Semen, 10-30 parts of stir-fried Ziziphus Jujuba Semen, 20-30 parts of Mother of Pearl, 20-30 parts of Dragon Bone, 20-30 parts of Oyster, 10-20 parts of Polygala Tenuifolia, and 10-20 parts of Radix Rehmanniae;

[0012] Further, a pharmaceutical composition for treating ventricular premature beats is composed of the following raw materials in parts by weight: 9 parts of Adenophora Root, 9 parts of Scrophularia Root, 15 parts of Salvia miltiorrhiza, 15 parts of Asparagus cochinchinensis, 15 parts of Radix Ophiopogonis, 20 parts of Semen Platycladi, 30 parts of stir-fried Semen Ziziphi Spinosae, 30 parts of Mother of Pearl, 30 parts of Dragon Bone, 30 parts of Oyster, 15 parts of Polygala Tenuifolia, and 15 parts of Radix Rehmanniae;

[0013] Further, a pharmaceutical composition for treating ventricular premature beats is composed of the following raw materials by weight: 9g of Adenophora Root, 9g of Scrophularia Root, 15g of Salvia miltiorrhiza, 15g of Asparagus cochinchinensis, 15g of Radix Ophiopogonis, 20g of Semen Platycladi, 30g of Stir-fried Semen Ziziphi Spinosae, 30g of Mother of Pearl, 30g of Dragon Bone, 30g of Oyster, 15g of Polygala Tenuifolia, and 15g of Radix Rehmanniae;

[0014] Another object of the present invention is to provide a method for preparing a pharmaceutical composition for treating premature ventricular beats.

[0015] Mix the following raw materials by weight: 9g of Adenophora Root, 9g of Scrophularia Root, 15g of Salvia Root, 15g of Asparagus Cochinchinensis, 15g of Radix Ophiopogonis, 20g of Semen Platycladi, 30g of Stir-fried Semen Ziziphi Spinosae, 30g of Mother of Pearl, 30g of Dragon Bone, 30g of Oyster, 15g of Polygala Tenuifolia, and 15g of Radix Rehmanniae; form a mixed medicine;

[0016] A dose of the mixed medicine is mixed with cold water, and then decocted three times after soaking, and the liquid medicines obtained after the three decoctions are mixed to obtain a mixed liquid medicine, which is a pharmaceutical composition for treating ventricular premature beats;

[0017] Furthermore, the decoction operation is filtering after decoction to obtain medicinal liquid A and medicinal residue A; soaking the medicinal residue A in cold water and then decoct it again, and filtering after decoction again to obtain medicinal liquid B and medicinal residue B; soaking the medicinal residue B in cold water and then decoct it for the third time, and filtering after the third decoction to obtain medicinal liquid C;

[0018] Further, the first decoction time is 10-20 minutes, the second decoction time is 25-35 minutes, and the third decoction time is 20-30 minutes; the amount of cold water added in the first decoction is 600-1000 ml, and the amount of cold water added in the second decoction is less than the amount of cold water added in the first decoction; the amount of cold water added in the third decoction is less than the amount of cold water added in the third decoction;

[0019] Furthermore, the soaking time is 30 minutes, and cold water soaking is required before each decoction;

[0020] Furthermore, the first decoction, the second decoction, and the third decoction are all firstly decocted with a rapid fire until boiling, and then continued to be decocted with a slow fire after boiling; and the time of each decoction is calculated starting from the time of boiling;

[0021] Further, the volumes of the drug solution A, the drug solution B, and the drug solution C are all 150-250 ml, and the volume of the mixed drug solution is 450-750 ml;

[0022] Another object of the present invention is to provide an application of a pharmaceutical composition for treating ventricular premature beats, wherein the pharmaceutical composition for treating ventricular premature beats is applied to treat ventricular premature beats of heart yin deficiency and heart malnutrition type;

[0023] Furthermore, the pharmaceutical composition for treating premature ventricular beats is added with medically acceptable adjuvants to prepare a decoction, capsule, granule, oral solution, pill or tablet;

[0024] Furthermore, the method for taking the mixed liquid medicine is to divide the mixed liquid medicine into 2 or 3 portions and take them orally within one day.

[0025] The pharmaceutical composition for treating ventricular premature beats of the present invention is a modern Chinese medicine designed according to the principle of Chinese medicine prescription of monarch, minister, assistant and envoy. The effects of the raw materials used are as follows:

[0026] Adenophora: sweet, slightly bitter, slightly cold in nature; enters the lung and stomach meridians; has the effects of nourishing yin and clearing heat, moistening the lungs and resolving phlegm, benefiting the stomach and promoting fluid production, nourishing the liver and kidneys, nourishing blood and calming the mind; commonly used for: treating respiratory diseases, improving digestive system symptoms, enhancing immunity, and maintaining health;

[0027] Scrophularia: cold in nature, sweet, bitter and salty in taste; enters the lung meridian, stomach meridian and kidney meridian; has the effects of clearing heat and cooling blood, nourishing yin and reducing fire, detoxifying and dispersing knots, nourishing yin and promoting body fluid, anti-inflammatory and sterilizing; commonly used for: treating febrile diseases, improving symptoms of yin deficiency and hyperactivity of fire, treating heat-toxic diseases, and maintaining health;

[0028] Danshen: bitter in taste, slightly cold in nature; enters the heart meridian and liver meridian; has the effects of promoting blood circulation and removing blood stasis, relieving pain, clearing the heart and relieving vexation, cooling blood and eliminating carbuncle, regulating blood lipids, resisting arteriosclerosis, and protecting myocardial cells; commonly used for: treating cardiovascular and cerebrovascular diseases, treating gynecological diseases, treating surgical diseases, and maintaining health;

[0029] Asparagus cochinchinensis: sweet, bitter, and cold in nature; it enters the lung meridian, kidney meridian, and stomach meridian; it has the effects of nourishing yin and promoting body fluid, nourishing yin and tonifying the kidney, clearing away heat and nourishing the stomach, moistening the intestines and relieving constipation, nourishing the liver and improving eyesight, strengthening the heart and preventing myocardial infarction, antibacterial and anti-inflammatory, and anti-tumor; it is often used to treat diseases caused by yin deficiency, dryness and heat, such as dry cough due to lung dryness, kidney yin deficiency, and damage to body fluid due to heat disease;

[0030] Ophiopogon japonicus: sweet, slightly bitter, slightly cold in nature; it enters the heart meridian, lung meridian and stomach meridian; it has the effects of nourishing yin and promoting body fluid, moistening the lungs and relieving cough, clearing the heart and relieving vexation, moistening the intestines and relieving constipation, resisting fatigue, scavenging free radicals: lowering blood sugar; it is often used to treat diseases caused by yin deficiency, dryness and heat, such as dry cough due to lung dryness, thirst due to stomach yin deficiency, irritability and insomnia, and constipation due to dry intestines;

[0031] Platycodon grandiflorum: sweet and neutral in nature; it enters the heart meridian, kidney meridian and large intestine meridian; it has the effects of nourishing the heart and calming the mind, moistening the intestines and relieving constipation, nourishing kidney yin, and replenishing deficiency; it is often used to treat palpitations and insomnia, dry intestines and constipation, and kidney yin deficiency;

[0032] The nature and flavor of fried jujube seeds are sweet, sour and flat; they belong to the heart meridian, liver meridian and gallbladder meridian; they have the effects of nourishing the heart and calming the mind: astringing sweat, promoting body fluid, preventing hypertension and protecting the heart; they are often used to treat palpitations, insomnia, dreaminess, spontaneous sweating, night sweats, loss of body fluid and thirst;

[0033] The nature and flavor of mother-of-pearl are salty and cold; it belongs to the liver meridian and the heart meridian; it has the effects of calming the liver and suppressing yang, calming the nerves and calming the nerves, improving eyesight and removing cataracts, detoxifying and promoting tissue regeneration, regulating endocrine, replenishing calcium and strengthening bones, and resisting allergies; it is often used to treat diseases caused by hyperactivity of liver yang and restlessness, such as headache, dizziness, insomnia, palpitations, and epilepsy;

[0034] Dragon bone is sweet, astringent and flat in nature and flavor; it passes through the heart meridian, liver meridian and kidney meridian; it has the effects of calming the nerves, calming the liver and suppressing yang, astringing and consolidating, strengthening tendons and bones, anti-inflammatory and analgesic, reducing swelling, antibacterial and anti-inflammatory, and regulating blood sugar; it is often used to treat insomnia, palpitations, dizziness, spermatorrhea, metrorrhagia, leukorrhea, spontaneous sweating and night sweats;

[0035] Oysters are salty, astringent, and slightly cold in nature and flavor. They enter the liver and kidney meridians. They have the effects of calming the mind, suppressing yang and replenishing yin, softening and dispersing lumps, astringing and consolidating, promoting fluid production and benefiting the stomach, and relieving acid and pain. They are often used to treat insomnia, palpitations, dizziness, tinnitus, deafness, spermatorrhea, metrorrhagia, and leukorrhea.

[0036] Polygala: bitter, pungent, warm in nature; enters the heart, kidney and lung meridians; has the effects of calming the mind, improving intelligence, removing phlegm and opening the orifices, dissipating carbuncle, antibacterial, anticonvulsant, sedative, uterine excitation, and lowering blood pressure; commonly used to treat nervous system diseases, respiratory system diseases, skin diseases, and heart-kidney disharmony;

[0037] Shengdi: sweet and bitter in taste, cold in nature; enters the heart, liver, and kidney meridians; has the effects of clearing heat and cooling blood, nourishing yin and promoting body fluid, stopping bleeding, calming the mind and relieving restlessness; mainly used for symptoms of febrile diseases damaging yin, red tongue and thirst, yin deficiency and internal heat, bone steaming and fatigue fever, internal heat and thirst, blood heat, dry intestines and constipation, and restlessness;

[0038] The medicinal composition for treating ventricular premature beats of the present invention is composed of Adenophora Root, Scrophularia Root, Salvia Root, Asparagus Cochinchinensis, Radix Ophiopogonis, Platycladus Semen, Fried Ziziphi Spinosae Seed, Mother of Pearl, Dragon Bone, Oyster, Polygala Tenuifolia and Radix Rehmanniae. The whole formula has the effects of invigorating qi, nourishing yin and blood, calming the mind, tranquilizing the nerves and relieving palpitations, and also has the effects of eliminating evil and strengthening the body. The formula uses "three ginsengs" (Adenophora stellariae, Salvia miltiorrhiza, Scrophularia ningpoensis) and "two winters" (Asparagus cochinchinensis, Ophiopogon japonicus) as the main ingredients to invigorate Qi, produce body fluid and nourish Yin, and also have the functions of promoting blood circulation, removing blood stasis, clearing away heat and detoxifying; mother-of-pearl, dragon bone and oyster are the auxiliary ingredients, among which cypress seed and fried jujube seed can restrain the heart Qi, nourish heart blood and calm the mind; mother-of-pearl, dragon bone and oyster can calm the liver and suppress Yang, and use heavy medicine to calm the mind and stabilize the spirit; the auxiliary herbs are Polygala tenuifolia and Rehmannia glutinosa. Polygala tenuifolia connects the heart and kidney to calm the mind and improve intelligence, and also has the functions of removing phlegm and opening the orifices; Rehmannia glutinosa clears heat and cools blood, nourishes Yin and produces body fluid; it treats both the symptoms and the root causes, and together achieves the effects of invigorating Qi, nourishing Yin and blood, calming the mind, improving intelligence, and also has the functions of removing evil and strengthening the body.

[0039] Beneficial effects of the present invention:

[0040] A pharmaceutical composition for treating ventricular premature beats of the present invention is developed based on the theory of monarch, minister, assistant and envoy of syndrome differentiation and treatment in traditional Chinese medicine; it is composed of Adenophora Root, Scrophularia Root, Salvia Root, Asparagus Codonopsis, Radix Ophiopogonis, Semen Platycladi, Fried Ziziphi Spinosae, Mother of Pearl, Dragon Bone, Oyster, Polygala Tenuifolia and Radix Rehmanniae; the monarch medicine is Adenophora Root, Scrophularia Root and Salvia Root; the minister medicine is Mother of Pearl, Dragon Bone and Oyster; the assistant and envoy medicine is Polygala Tenuifolia and Radix Rehmanniae; the monarch medicine replenishes qi, produces body fluid and nourishes yin, and also activates blood circulation, removes blood stasis, clears away heat and detoxifies; Semen Platycladi and Fried Ziziphi Spinosae can restrain heart qi, nourish heart blood and calm the mind; the minister medicine calms the liver and suppresses yang, and calms the mind and stabilizes the mind; the assistant and envoy medicine communicates the heart and kidney and calms the mind and improves intelligence, and also removes phlegm and opens the orifices, clears away heat and cools blood, and nourishes yin and produces body fluid. The whole prescription treats both the symptoms and the root causes, and plays the role of replenishing qi, nourishing yin and blood, calming the mind, calming the mind and improving intelligence, and also removing evil and strengthening the body; the pharmaceutical composition of the present invention improves the atrial structure and prevents and treats ventricular premature beats by inhibiting the inflammatory reaction closely related to the atrial structure. DETAILED DESCRIPTION

[0041] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] Example 1

[0043] In this embodiment, a pharmaceutical composition for treating ventricular premature beats is composed of the following raw materials in parts by weight: 9-20 parts of Adenophora Root, 9-20 parts of Scrophularia Root, 9-20 parts of Salvia miltiorrhiza, 10-20 parts of Asparagus cochinchinensis, 10-20 parts of Radix Ophiopogonis, 10-30 parts of Platycladus orientalis, 10-30 parts of stir-fried Ziziphus jujuba seeds, 20-30 parts of mother-of-pearl, 20-30 parts of Dragon Bone, 20-30 parts of Oyster, 10-20 parts of Polygala Tenuifolia, and 10-20 parts of Radix Rehmanniae;

[0044] Example 2

[0045] In this embodiment, a pharmaceutical composition for treating premature ventricular beats is composed of the following raw materials in parts by weight: 9 parts of Adenophora Root, 9 parts of Scrophularia Root, 15 parts of Salvia miltiorrhiza, 15 parts of Asparagus cochinchinensis, 15 parts of Radix Ophiopogonis, 20 parts of Semen Platycladi, 30 parts of stir-fried Semen Ziziphi Spinosae, 30 parts of Mother of Pearl, 30 parts of Dragon Bone, 30 parts of Oyster, 15 parts of Polygala Tenuifolia, and 15 parts of Radix Rehmanniae;

[0046] Example 3

[0047] In this embodiment, a pharmaceutical composition for treating ventricular premature beats is composed of the following raw materials by weight: 9g of Adenophora Root, 9g of Scrophularia Root, 15g of Salvia miltiorrhiza, 15g of Asparagus cochinchinensis, 15g of Radix Ophiopogonis, 20g of Semen Platycladi, 30g of Stir-fried Semen Ziziphi Spinosae, 30g of Mother of Pearl, 30g of Dragon Bone, 30g of Oyster, 15g of Polygala Tenuifolia, and 15g of Radix Rehmanniae;

[0048] Example 4

[0049] In this embodiment, a pharmaceutical composition for treating premature ventricular beats is prepared by the following preparation method, specifically:

[0050] The raw materials in the above embodiment 3 are combined into a mixed medicine according to the weight of grams; the mixed medicine is mixed with cold water, and then decocted three times after soaking, and the liquid medicines obtained after the three decoctions are mixed to obtain a mixed liquid medicine, which is a pharmaceutical composition for treating ventricular premature beats;

[0051] In this embodiment, the above-mentioned decoction operation is filtering after decoction to obtain liquid medicine A and residue A; soaking the residue A in cold water and then decoct it again, and filtering after decoction again to obtain liquid medicine B and residue B; soaking the residue B in cold water and then decoct it for the third time, and filtering after the third decoction to obtain liquid medicine C;

[0052] In this embodiment, the first decoction time is 10-20 minutes, the second decoction time is 25-35 minutes, and the third decoction time is 20-30 minutes; the amount of cold water added in the first decoction is 600-1000 ml, and the amount of cold water added in the second decoction is less than the amount of cold water added in the first decoction; the amount of cold water added in the third decoction is less than the amount of cold water added in the second decoction;

[0053] In this embodiment, the soaking time is 30 minutes, and cold water soaking is required before each decoction;

[0054] In this embodiment, the first decoction, the second decoction, and the third decoction are all firstly boiled with a rapid fire, and then continued to be boiled with a slow fire after boiling; the time of each decoction is calculated from the time after boiling;

[0055] In this embodiment, the volumes of the drug solution A, the drug solution B, and the drug solution C are all 150-250 ml, and the total volume of the mixed drug solution is 450-750 ml;

[0056] Example 5

[0057] In this embodiment, a method for taking a pharmaceutical composition for treating premature ventricular beats is to divide the mixed liquid prepared in the above embodiment 4 into 2-3 portions and take them all within one day;

[0058] Example 6

[0059] In this embodiment, based on the above-mentioned embodiments 1-5, the functions and indications of a pharmaceutical composition for treating ventricular premature beats of the present invention are: improving the symptoms of palpitation, chest tightness, shortness of breath and fatigue in patients with ventricular premature beats, and being able to reduce the number of clinical attacks of patients with ventricular premature beats, and being able to significantly reduce the expression of inflammatory factors in the serum of patients with ventricular premature beats, thereby being able to effectively alleviate the symptoms of ventricular premature beats, reduce the frequency of ventricular premature beats, and improve the quality of life of patients;

[0060] Example 7

[0061] Typical cases:

[0062] Case 1: Patient Wang, male, 45 years old, Han nationality, from Wusu City, Tacheng District, Xinjiang, professional technician. He was diagnosed with "intermittent palpitations for 1 and a half years, aggravated with chest tightness for 2 months" at the local hospital before admission. He was diagnosed with "frequent ventricular premature beats with arrhythmia" at the local hospital, and no abnormalities were found in coronary CTA. He had been taking bisoprolol tablets 5mg / day for a long time, but still had repeated palpitations, chest tightness, shortness of breath, fatigue, and insomnia. After visiting our hospital, the 24h dynamic electrocardiogram (Holter) examination indicated that the number of ventricular premature beats was 15640 times / 24h. The above-mentioned drug combination of this application, decoction, 200ml / time, twice a day, taken after meals in the morning and evening, continued to take bisoprolol tablets 5mg / day, and the 24h dynamic electrocardiogram (Holter) rechecked one month later indicated that the number of ventricular premature beats was reduced to 9025 times / 24h, and the patient's palpitations, chest tightness, shortness of breath, fatigue, and insomnia symptoms were significantly relieved.

[0063] Case 2: Patient Wu, female, 54 years old, Han nationality, from Xinyuan County, Yili, Xinjiang, engaged in self-employment. The patient came to our hospital for treatment due to "repeated palpitations for more than 3 years, aggravated by chest tightness and shortness of breath for 1 month". The patient reported that he had been diagnosed with "frequent ventricular premature beats due to arrhythmia" in the local hospital for 3 years due to palpitations. He had been taking metoprolol sustained-release tablets 47.5 mg / day for a long time. However, he had repeated palpitations, chest tightness, shortness of breath, fatigue, insomnia, dry mouth and throat symptoms after being tired and staying up late. After visiting our hospital, 24-hour dynamic electrocardiogram (Holter) examination showed that the number of ventricular premature beats was 12575 times / 24h. The above-mentioned drug combination of this application, decoction, 200 ml / time, twice a day, taken in the morning and evening after meals, continued to take metoprolol sustained-release tablets 47.5 mg / day, and the 24-hour dynamic electrocardiogram (Holter) re-examination 2 months later showed that the number of ventricular premature beats decreased to 1187 times / 24h, and the patient's palpitations, chest tightness, shortness of breath, fatigue, insomnia, dry mouth and throat symptoms were significantly improved than before.

[0064] Case 3: Patient Zhang, female, 31 years old, Han nationality, from Urumqi, Xinjiang, professional technician. She came to the hospital for "intermittent palpitations for more than 7 years, aggravated with chest tightness for 1 month". The patient reported that she had palpitations and discomfort every time she stayed up late and worked hard during school 7 years ago. She was diagnosed with "frequent ventricular premature beats due to arrhythmia". She took metoprolol sustained-release tablets 47.5mg / day and Shensong Yangxin Capsules 2 capsules / time, 3 times / day for a long time, but she still had repeated palpitations, chest tightness, insomnia, dreaminess, fatigue and weakness after working hard and staying up late. The 24h dynamic electrocardiogram (Holter) examination showed that the maximum number of ventricular premature beats reached 15. The patient had been treated more than 700 times. It was suggested that the patient undergo cardiac radiofrequency ablation, but the patient refused. After visiting our hospital, the above-mentioned drug combination in this application was used, decoction, 200 ml / time, twice a day, in the morning and evening after meals, and continued to take metoprolol sustained-release tablets 47.5 mg / day. Later, the 24-hour dynamic electrocardiogram (Holter) review indicated that the number of ventricular premature beats decreased to 4759 times / 24h, and the patient's symptoms of palpitations, chest tightness, fatigue, insomnia and dreaminess were significantly improved compared with before.

[0065] Case 4: Patient Yang, female, 26 years old, Han nationality, native of Wusu City, Xinjiang, student (medical student). She came to the hospital for "intermittent palpitations for more than 3 years, aggravated with chest tightness for 1 week". The patient reported that she had palpitations and chest tightness when she stayed up late and worked hard 3 years ago. She underwent 24-hour dynamic electrocardiogram (Holter) examinations many times, which showed frequent ventricular premature beats, with the maximum number reaching 16305 times / 24 hours. She took metoprolol sustained-release tablets 23.75mg / day, Shensong Yangxin Capsules 2 capsules / time, 3 times / day, and potassium magnesium aspartate for a long time, but she still had repeated palpitations, chest tightness, fatigue and weakness after staying up late on duty. The patient was advised to undergo cardiac radiofrequency ablation, but refused. After visiting our hospital, he was treated with the above-mentioned drug combination in this application, decoction, 200 ml / time, twice a day, after meals in the morning and evening, and continued to take metoprolol sustained-release tablets 23.75 mg / day as western medicine. After taking the above-mentioned drugs in this application for 1 month, the 24-hour dynamic electrocardiogram (Holter) showed that the number of ventricular premature beats decreased to 11731 times / 24h, and the patient's symptoms of palpitations, chest tightness, fatigue and weakness were significantly improved compared with before.

[0066] Example 8

[0067] The invention discloses a prescription for treating ventricular premature beats of heart yin deficiency and heart spirit malnutrition type and a preparation method thereof, comprising ginseng, scrophularia, salvia miltiorrhiza, asparagus cochinchinensis, ophiopogon japonicus, cypress seed, stir-fried jujube seed, mother-of-pearl, dragon bone, oyster, polygala tenuifolia and rehmannia root. The medicine of the invention can significantly improve the symptoms of palpitation, chest tightness, shortness of breath and fatigue in patients with ventricular premature beats, reduce the number of clinical attacks of patients with ventricular premature beats, significantly reduce the expression of inflammatory factors in the serum of patients with ventricular premature beats, and further effectively alleviate the symptoms of ventricular premature beats, reduce the attack frequency of ventricular premature beats, and improve the quality of life of patients, and has strong practicality and popularization.

[0068] The pharmaceutical composition of the present invention is a Chinese medicine compound for treating palpitations, deficiency of yin and blood, and heart and mind nourishment syndrome. The whole prescription plays the effects of invigorating qi, nourishing yin and blood, calming the mind, calming the nerves and stabilizing palpitations, and removing evil and strengthening the body. In the prescription, "three ginsengs" (Adenophora Root, Salvia Miltiorrhiza Root, Scrophularia Root) and two winters (Asparagus Cochinchinensis, Radix Ophiopogonis) are used as the main ingredients to invigorate qi, promote body fluid and nourish yin, and promote blood circulation, remove blood stasis, and clear away heat and detoxify. Mother-of-pearl, dragon bone, and oyster are the ministers, among which cypress seed and stir-fried jujube seed can astringe the heart qi, nourish the heart blood and calm the mind, mother-of-pearl, dragon bone, and oyster can calm the liver and suppress yang, calm the mind and stabilize the mind, and the auxiliary drugs are Polygala Tenuifolia and Radix Rehmanniae. Polygala Tenuifolia communicates with the heart and kidney to calm the mind and benefit the intelligence, and removes phlegm and opens the mind, and Radix Rehmanniae clears heat and cools blood, nourishes yin and produces body fluid; treating both the symptoms and the root causes, playing the effects of invigorating qi, nourishing yin and blood, calming the mind, calming the nerves and benefiting the intelligence, and removing evil and strengthening the body.

[0069] The Chinese medicine compound of the present invention is an agreed prescription for the treatment of palpitations, yin and blood deficiency, and heart and mind malnutrition syndrome in the cardiovascular department of the heart center. It has been used in the hospital for more than ten years. It is applied to the treatment of patients with ventricular premature beats. After long-term clinical observation and follow-up, it is found that the Chinese medicine compound of the present invention can significantly improve the symptoms of palpitations, chest tightness, and shortness of breath in patients with ventricular premature beats, and can reduce the number of clinical attacks of patients with ventricular premature beats, prevent the recurrence of ventricular premature beats, and can reduce the incidence of complications in patients with ventricular premature beats.

[0070] Based on more than ten years of clinical application, the inventor believes that the Chinese medicine compound of the present invention has a preventive and therapeutic effect on patients with ventricular premature beats. The occurrence and development of ventricular premature beats are closely related to atrial structure, and inflammatory response affects changes in atrial structure. The inventor found that the Chinese medicine compound of the present invention can inhibit inflammatory response, improve atrial structural remodeling, and thus prevent and treat the occurrence and development of ventricular premature beats.

[0071] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A pharmaceutical composition for treating premature ventricular contractions, characterized in that: The invention is composed of the following raw materials in parts by weight: 9-20 parts of Adenophora Root, 9-20 parts of Scrophularia Root, 9-20 parts of Salvia miltiorrhiza, 10-20 parts of Asparagus Cochinchinensis, 10-20 parts of Ophiopogon japonicus, 10-30 parts of Platycladus orientalis seeds, 10-30 parts of stir-fried Ziziphus jujuba seeds, 20-30 parts of mother of pearl, 20-30 parts of dragon bones, 20-30 parts of oysters, 10-20 parts of Polygala Tenuifolia and 10-20 parts of Rehmannia glutinosa.

2. A pharmaceutical composition for treating ventricular premature beats according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 9 parts of Adenophora Root, 9 parts of Scrophularia Root, 15 parts of Salvia miltiorrhiza, 15 parts of Asparagus cochinchinensis, 15 parts of Ophiopogon japonicus, 20 parts of Platycladus orientalis seeds, 30 parts of stir-fried Ziziphus jujuba seeds, 30 parts of mother of pearl, 30 parts of Dragon Bone, 30 parts of Oyster, 15 parts of Polygala Tenuifolia and 15 parts of Rehmannia glutinosa.

3. A pharmaceutical composition for treating ventricular premature beats according to claim 1, characterized in that: A pharmaceutical composition for treating ventricular premature beats is composed of the following raw materials by weight: 9g of Adenophora Root, 9g of Scrophularia Root, 15g of Salvia miltiorrhiza, 15g of Asparagus cochinchinensis, 15g of Ophiopogon japonicus, 20g of Platycladus orientalis, 30g of stir-fried Ziziphus jujuba seeds, 30g of mother-of-pearl, 30g of Dragon Bone, 30g of Oyster, 15g of Polygala Tenuifolia, and 15g of Rehmannia glutinosa.

4. A method for preparing a pharmaceutical composition for treating premature ventricular contractions, characterized in that: According to the weight proportions as claimed in claim 3, 9g of Adenophora Root, 9g of Scrophularia Root, 15g of Salvia miltiorrhiza, 15g of Asparagus cochinchinensis, 15g of Ophiopogon japonicus, 20g of Platycladus orientalis, 30g of stir-fried Ziziphus jujuba seeds, 30g of Mother of Pearl, 30g of Dragon Bone, 30g of Oyster, 15g of Polygala Tenuifolia and 15g of Rehmannia glutinosa are mixed to form a mixed medicine; the mixed medicine is mixed with cold water, and the mixture is decocted three times after soaking, and the medicinal liquids obtained after the three decoctions are mixed to obtain a mixed medicinal liquid, which is a pharmaceutical composition for treating ventricular premature beats.

5. A method for preparing a pharmaceutical composition for treating premature ventricular contractions according to claim 4, characterized in that: The decoction operation is as follows: filtering after the first decoction to obtain medicinal liquid A and medicinal residue A; decocting the medicinal residue A again after soaking it in cold water, and filtering after the second decoction to obtain medicinal liquid B and medicinal residue B; decocting the medicinal residue B for the third time after soaking it in cold water, and filtering after the third decoction to obtain medicinal liquid C.

6. A method for preparing a pharmaceutical composition for treating premature ventricular contractions according to claim 4, characterized in that: The first decoction time is 10-20 minutes, the second decoction time is 25-35 minutes, and the third decoction time is 20-30 minutes; the amount of cold water added in the first decoction is 600-1000ml, and the amount of cold water added in the second decoction is less than that in the first decoction; the amount of cold water added in the third decoction is less than that in the third decoction; the volumes of the medicinal liquid A, the medicinal liquid B, and the medicinal liquid C are all 150-250ml, and the volume of the mixed medicinal liquid is 450-750ml.

7. A method for preparing a pharmaceutical composition for treating premature ventricular contractions according to claim 4, characterized in that: The soaking time for the three times is 30 minutes, and cold water soaking is required before each decoction.

8. A method for preparing a pharmaceutical composition for treating premature ventricular contractions according to claim 4, characterized in that: The first decoction, the second decoction and the third decoction are all firstly decocted with a rapid fire until boiling, and then continued to be decocted with a slow fire after boiling; the time of each decoction is calculated from the time after boiling.

9. Use of a pharmaceutical composition for treating premature ventricular contractions, characterized in that: The pharmaceutical composition for treating ventricular premature beats is used to treat ventricular premature beats of heart yin deficiency and heart malnutrition type; the pharmaceutical composition for treating ventricular premature beats is added with medically acceptable excipients to prepare decoctions, capsules, granules, oral liquids, pills, and tablets.

10. The use of the mixed liquid medicine according to claim 4, characterized in that: The method for taking the mixed liquid medicine is to divide the mixed liquid medicine into 2 or 3 portions and take them orally within one day.