Equipment for detecting content of aluminum element in sodium bicarbonate Ringer's injection

Abstract

The invention relates to the technical field of pharmaceutical analysis, in particular to a sodium bicarbonate ringer injection aluminum element content detection device which comprises a workbench, and a pretreatment mechanism, a muffle furnace, a liquid separation mechanism, a dilution mechanism and a spectrophotometer are arranged on the workbench; the pretreatment mechanism is used for heating and carbonizing the sodium bicarbonate Ringer's injection in the platinum crucible; the muffle furnace is used for further ashing the carbonized sodium bicarbonate Ringer's injection; the liquid separation mechanism is used for adding water to dissolve residues after ashing of the sodium bicarbonate ringer injection and extracting to obtain a test solution; the diluting mechanism is used for diluting the aluminum standard solution and the buffer solution to obtain a reference solution and a blank solution. The method has the characteristic of automatically detecting the content of the aluminum element in the sodium bicarbonate Ringer's injection, and solves the problems that the risk that the aluminum element exceeds the standard exists in the existing sodium bicarbonate Ringer's injection, and high-concentration aluminum intake may affect health.

Description

Technical Field

[0001] The invention relates to the technical field of drug analysis, in particular to a device for detecting the content of aluminum in sodium bicarbonate Ringer's injection. Background Art

[0002] Sodium bicarbonate Ringer's injection is a compound injection used for clinical treatment, mainly used to correct electrolyte imbalance, acid-base imbalance and fluid supplementation in the body. It combines the advantages of Ringer's injection and sodium bicarbonate and is suitable for a variety of clinical situations.

[0003] Detecting the aluminum content in sodium bicarbonate Ringer's injection is an important quality control step because aluminum is a potentially harmful impurity, and its presence is usually due to contamination in raw materials or production processes. High concentrations of aluminum intake may cause health problems, especially in patients with renal insufficiency. Therefore, strict control and detection of aluminum content is essential to ensure the safety and quality of drugs. To this end, we propose a device for detecting the aluminum content in sodium bicarbonate Ringer's injection. Summary of the invention

[0004] Based on the technical problems existing in the background technology, the present invention proposes a device for detecting the aluminum content in sodium bicarbonate Ringer's injection, which has the characteristic of automatically realizing the detection of the aluminum content in sodium bicarbonate Ringer's injection, and solves the risk of excessive aluminum in the existing detection of sodium bicarbonate Ringer's injection, and the problem that high concentration of aluminum intake may affect health.

[0005] The present invention provides the following technical solution: an apparatus for detecting the content of aluminum in sodium bicarbonate Ringer's injection, comprising a workbench, on which a pretreatment mechanism, a muffle furnace, a liquid separation mechanism, a dilution mechanism and a spectrophotometer are arranged;

[0006] The pretreatment mechanism is used to heat and carbonize the sodium bicarbonate Ringer's injection in the platinum crucible; the muffle furnace is used to further ashed the carbonized sodium bicarbonate Ringer's injection;

[0007] The liquid separation mechanism is used to dissolve the residue after the sodium bicarbonate Ringer's injection is ashed by adding water, and extract to obtain the test solution;

[0008] The dilution mechanism is used to dilute the aluminum standard solution and then place it in the liquid separation mechanism for extraction to obtain a reference solution;

[0009] The dilution mechanism is used to dilute the buffer solution and then place it in the liquid separation mechanism for extraction to obtain a blank solution;

[0010] The spectrophotometer is used to measure the fluorescence intensity of the test solution, the reference solution and the blank solution.

[0011] Preferably, the pretreatment mechanism comprises a heating furnace, which is used to heat the platinum crucible. A sample addition tube and a sulfuric acid addition tube are provided at a position corresponding to the platinum crucible inside the pretreatment mechanism, which are used to add a certain amount of drug solution and sulfuric acid into the platinum crucible.

[0012] Preferably, a smoke detection module is provided inside the pretreatment mechanism, and the smoke detection module is used to monitor whether smoke is generated when the heating furnace heats the solution in the platinum crucible.

[0013] Preferably, the liquid separation mechanism comprises a separating funnel, which is connected to the platinum crucible via a liquid infusion tube 1 and is used to absorb the solution after the residue in the platinum crucible is dissolved;

[0014] The separating funnel is connected with a second infusion tube, and the 8-hydroxyquinoline chloroform solution is added through the second infusion tube.

[0015] Preferably, the liquid separation mechanism further comprises a bracket and a telescopic rod, the liquid separation funnel is slidably mounted on the bracket, and the bracket is fixed on the workbench;

[0016] The workbench is provided with a test sample container, a reference sample container and a blank container, and the telescopic rod is used to drive the separating funnel to translate and transfer the solution to the test sample container, the reference sample container and the blank container respectively.

[0017] Preferably, the dilution mechanism comprises a dilution box, which is connected to the separatory funnel via a liquid outlet pipe, and the dilution box is used to transport the diluted liquid to the separatory funnel.

[0018] Preferably, the dilution box is connected to a liquid inlet pipe and a dilution pipe, and the liquid inlet pipe, the dilution pipe and the liquid outlet pipe are all provided with flow valves.

[0019] Preferably, a motor is installed on the dilution box, and the output shaft of the motor is connected to the stirring frame inside the dilution box, and the motor is used to drive the stirring frame to rotate and mix the solution.

[0020] Preferably, it further comprises a cleaning box, the cleaning box is provided with a water pump, the water pump is connected to the dilution pipe of the dilution box through a water pipe 1, and the water pipe 1 is used to provide dilution liquid and cleaning water for the dilution box;

[0021] The water pump is connected to the platinum crucible through the second water pipe, and the platinum crucible is used to provide dissolved water and cleaning water for the platinum crucible. The first water pipe and the second water pipe are both provided with flow valves.

[0022] Preferably, a waste liquid box is provided on the workbench, and the waste liquid box is used to collect waste liquid from the dilution box, the separatory funnel and the platinum crucible; and a control box is provided on the workbench.

[0023] The present invention provides a device for detecting the content of aluminum in sodium bicarbonate Ringer's injection. By setting a pretreatment mechanism, the sample in a platinum crucible can be evaporated to near dryness, and sulfuric acid is added to a sulfuric acid adding tube to continue heating and carbonizing until no smoke is produced, thus completing the automated pretreatment. The residue is obtained by ashing in a muffle furnace, and after being dissolved in water, it is extracted three times by a liquid separation mechanism to obtain an extract, which is placed in a test sample container to obtain a test sample. The aluminum standard solution and the buffer solution can be diluted by a dilution mechanism, and extracted by the liquid separation mechanism to obtain a reference solution and a blank solution, respectively, which are placed in a reference sample container and a blank container. Finally, the fluorescence intensity of the three is measured by a spectrophotometer to realize the automated detection of the aluminum content. The risk of excessive aluminum in the existing detection of sodium bicarbonate Ringer's injection and the problem that high concentrations of aluminum intake may affect health are solved. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the structure of the present invention;

[0025] Figure 2 It is a schematic diagram of the structure of the pretreatment mechanism of the present invention;

[0026] Figure 3 This is a schematic diagram of the dilution mechanism structure of the present invention;

[0027] Figure 4 It is a schematic diagram of the structure of the liquid separation mechanism of the present invention.

[0028] In the figure: 1. workbench; 2. pretreatment mechanism; 21. heating furnace; 22. sample addition tube; 23. sulfuric acid addition tube; 24. flue gas detection module; 3. muffle furnace; 4. platinum crucible; 5. liquid separation mechanism; 51. separating funnel; 52. bracket; 53. infusion tube one; 54. telescopic rod; 55. infusion tube two; 6. dilution mechanism; 61. dilution box; 62. liquid inlet pipe; 63. dilution tube; 64. liquid outlet pipe; 65. motor; 66. stirring frame; 7. cleaning box; 71. water pump; 72. water pipe one; 73. water pipe two; 8. waste liquid box; 9. control box; 10. test sample container; 11. reference sample container; 12. blank container. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] like Figure 1As shown, the present invention provides a technical solution: a device for detecting the content of aluminum in sodium bicarbonate Ringer's injection, comprising a workbench 1, on which a pretreatment mechanism 2, a muffle furnace 3, a liquid separation mechanism 5, a dilution mechanism 6 and a spectrophotometer are arranged;

[0031] The pretreatment mechanism 2 is used to heat and carbonize the sodium bicarbonate Ringer's injection in the platinum crucible 4; the muffle furnace 3 is used to further ashed the carbonized sodium bicarbonate Ringer's injection;

[0032] The liquid separation mechanism 5 is used to dissolve the residue after the sodium bicarbonate Ringer's injection is ashed by adding water, and extract to obtain the test solution;

[0033] like Figure 2 As shown, the pretreatment mechanism 2 includes a heating furnace 21, which is used to heat the platinum crucible 4. A sample addition tube 22 and a sulfuric acid addition tube 23 are provided at a position corresponding to the platinum crucible 4 inside the pretreatment mechanism 2, which are used to add a certain amount of liquid medicine and sulfuric acid to the platinum crucible 4. Flow valves are provided on the sample addition tube 22 and the sulfuric acid addition tube.

[0034] A smoke detection module 24 is disposed inside the pretreatment mechanism 2 , and the smoke detection module 24 can monitor whether smoke is generated when the heating furnace 21 heats the solution in the platinum crucible 4 .

[0035] like Figure 4 As shown, the liquid separation mechanism 5 includes a separating funnel 51, which is connected to the platinum crucible 4 through an infusion tube 1 53 and can absorb the solution after the residue in the platinum crucible 4 is dissolved; the separating funnel 51 is connected to an infusion tube 2 55, and 8-hydroxyquinoline chloroform solution is added through the infusion tube 2 55.

[0036] Preparation of the test solution: Place a platinum crucible 4 on a heating furnace 21, and place 80 ml of sodium bicarbonate Ringer's injection in the platinum crucible 4 through a sample addition tube 22, evaporate until nearly dry, add 5 ml of sulfuric acid through a sulfuric acid addition tube 23, continue heating and carbonizing until no smoke is produced, and monitor the presence of smoke through a smoke detection module 24, which is specifically a visual camera.

[0037] Then the platinum crucible 4 and the carbonized sample are placed in a muffle furnace 3 at 600° C. for ash treatment for 3 h, and the residue is dissolved by adding 100 ml of water through a cleaning box 7, a water pump 71 and a water pipe 73.

[0038] The above solution is transferred to a separatory funnel 51, which is provided with a pump body inside for sucking and discharging liquid. After the separatory funnel 51 sucks the dissolved sample solution, 0.5% 8-hydroxyquinoline chloroform solution is added through the infusion tube 55 for extraction three times (20ml, 20ml, 10ml), the extracts are combined, placed in a test sample container 10, i.e., a 50ml volumetric flask, chloroform is added to the scale, and the test sample solution is obtained by shaking.

[0039] like Figure 3 As shown, the dilution mechanism 6 can dilute the aluminum standard solution and place it in the liquid separation mechanism 5 for extraction to obtain a reference solution; the dilution mechanism 6 is used to dilute the buffer solution and place it in the liquid separation mechanism 5 for extraction to obtain a blank solution; the dilution mechanism 6 includes a dilution box 61, which is connected to the separating funnel 51 through a liquid outlet pipe 64, and the dilution box 61 is used to transport the diluted liquid to the separating funnel 51.

[0040] The dilution box 61 is connected to a liquid inlet pipe 62 and a dilution pipe 63. A motor 65 is installed on the dilution box 61. The output shaft of the motor 65 is connected to a stirring frame 66 inside the dilution box 61.

[0041] Preparation of reference solution: 1.0 ml of aluminum standard solution (accurately measure an appropriate amount of aluminum single element standard solution and dilute with water to make a solution containing 2.0 μg of aluminum per 1 ml) is input into the inlet pipe 62 of the dilution box 61, and 99 ml of water and 10 ml of acetic acid-ammonium acetate buffer solution (pH 6.0) are added through the dilution pipe 63. Water is added from the cleaning water tank and the water pump 71 through the water pipe 1 72. Flow valves are set on the inlet pipe 62, the dilution pipe 63 and the outlet pipe 64. The motor 65 drives the stirring frame 66 to rotate and mix the aluminum standard solution, water and acetic acid-ammonium acetate buffer solution. The mixed solution enters the separating funnel 51 through the liquid outlet pipe 64. The separating funnel 51 adds 0.5% 8-hydroxyquinoline chloroform solution through the infusion tube 55 for extraction three times (20ml, 20ml, 10ml), and the extracts are combined and placed in the reference substance container 11, that is, a 50ml volumetric flask, and chloroform is added to the scale. The reference substance solution is obtained by shaking.

[0042] Preparation of blank solution: 10 ml of acetic acid-ammonium acetate buffer solution (pH 6.0) is quantitatively added to the dilution box 61 through the liquid inlet pipe 62, and 100 ml of water is added through the dilution pipe 63 and the second infusion pipe 55. The motor 65 drives the stirring frame 66 to rotate and mix the water and the acetic acid-ammonium acetate buffer solution. The mixed solution enters the separating funnel 51 through the liquid outlet pipe 64. The separating funnel 51 adds 0.5% 8-hydroxyquinoline chloroform solution through the second infusion pipe 55 for extraction three times (20 ml, 20 ml, 10 ml), and the extracts are combined and placed in the blank container 12, i.e., a 50 ml volumetric bottle, and chloroform is added to the scale. Shake well to obtain a blank solution.

[0043] Take the above three solutions and measure the fluorescence intensity at the excitation wavelength of 392nm and the emission wavelength of 518nm in the spectrophotometer. The limit of aluminum content in sodium bicarbonate Ringer's injection is: the fluorescence intensity of the test solution should not be greater than the fluorescence intensity of the reference solution (25μg / L).

[0044] In another embodiment, the liquid separation mechanism 5 also includes a bracket 52 and a telescopic rod 54, and the separating funnel 51 can be slidably installed on the bracket 52, and the bracket 52 is fixed on the workbench 1; the workbench 1 is provided with a test sample container 10, a reference sample container 11 and a blank container 12, and the telescopic rod 54 can drive the separating funnel 51 to move horizontally.

[0045] The arrangement of the telescopic rod 54 and the bracket 52 can adjust the position of the separating funnel 51, so that the liquid in the separating funnel 51 can be automatically placed in the test container 10, the reference container 11 and the blank container 12 placed side by side.

[0046] In another embodiment, a cleaning box 7 is further included, on which a water pump 71 is arranged, and the water pump 71 is connected to the dilution tube 63 of the dilution box 61 through a water pipe 72, and the water pipe 72 is used to provide the dilution box 61 with dilution liquid and cleaning water; because the separatory funnel 51 needs to prepare the test solution, the reference solution and the blank solution in sequence, and the dilution box 61 needs to prepare the reference solution and the blank solution, in order to avoid mutual influence between different solutions, after the test solution is prepared, the separatory funnel 51 needs to be rinsed by the cleaning box 7 and the water pump 71.

[0047] The water pump 71 is connected to the platinum crucible 4 through the water pipe 2 73. The platinum crucible 4 is used to provide dissolving water and cleaning water for the platinum crucible 4. The water pipe 1 72 and the water pipe 2 73 are both provided with flow valves, and the flow valves can control the addition amount. The water pipe 1 72 and the water pipe 2 73 can be used to dissolve the residue in the platinum crucible 4 on the one hand, and provide water for the dilution process of the reference solution and the blank solution on the other hand, and finally can also be used to rinse the dilution box 61 and the separatory funnel 51.

[0048] In another embodiment, a waste liquid tank 8 is provided on the workbench 1, and the waste liquid tank 8 can collect waste liquid from the dilution tank 61, the separating funnel 51 and the platinum crucible 4; a control box 9 is provided on the workbench 1, and the control box 9 is a PLC controller for controlling the operation of various components such as various telescopic rods 54 and flow valves.

[0049] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A device for detecting the content of aluminum in sodium bicarbonate Ringer's injection, characterized in that: The invention comprises a workbench (1), on which a pretreatment mechanism (2), a muffle furnace (3), a liquid separation mechanism (5), a dilution mechanism (6) and a spectrophotometer are arranged; The pretreatment mechanism (2) is used to heat and carbonize the sodium bicarbonate Ringer's injection in the platinum crucible (4); the muffle furnace (3) is used to further ash the carbonized sodium bicarbonate Ringer's injection; The liquid separation mechanism (5) is used to dissolve the residue after the sodium bicarbonate Ringer's injection is ashed by adding water, and extract to obtain the test solution; The dilution mechanism (6) is used to dilute the aluminum standard solution and place it in the liquid separation mechanism (5) for extraction to obtain a reference solution; The diluting mechanism (6) is used to dilute the buffer solution and then place it in the liquid separation mechanism (5) for extraction to obtain a blank solution; The spectrophotometer is used to measure the fluorescence intensity of the test solution, the reference solution and the blank solution.

2. The device for detecting the aluminum content in sodium bicarbonate Ringer's injection according to claim 1, characterized in that: The pretreatment mechanism (2) comprises a heating furnace (21) for heating the platinum crucible (4); a sample addition tube (22) and a sulfuric acid addition tube (23) are arranged at a position corresponding to the platinum crucible (4) inside the pretreatment mechanism (2) for adding a quantitative amount of liquid medicine and sulfuric acid into the platinum crucible (4).

3. The device for detecting the aluminum content in sodium bicarbonate Ringer's injection according to claim 2, characterized in that: A smoke detection module (24) is provided inside the pretreatment mechanism (2), and the smoke detection module (24) is used to monitor whether smoke is generated when the heating furnace (21) heats the solution in the platinum crucible (4).

4. The device for detecting the aluminum content in sodium bicarbonate Ringer's injection according to claim 1, characterized in that: The liquid separation mechanism (5) comprises a liquid separation funnel (51), which is connected to the platinum crucible (4) via a liquid infusion tube (53) and is used to absorb the solution after the residue in the platinum crucible (4) is dissolved; The separating funnel (51) is connected to a second infusion tube (55), and the 8-hydroxyquinoline chloroform solution is added through the second infusion tube (55).

5. The device for detecting the aluminum content in sodium bicarbonate Ringer's injection according to claim 4, characterized in that: The liquid separation mechanism (5) further comprises a bracket (52) and a telescopic rod (54), the liquid separation funnel (51) is slidably mounted on the bracket (52), and the bracket (52) is fixed on the workbench (1); The workbench (1) is provided with a test sample container (10), a reference sample container (11) and a blank container (12); the telescopic rod (54) is used to drive the separating funnel (51) to move horizontally and transfer the solution to the test sample container (10), the reference sample container (11) and the blank container (12) respectively.

6. The device for detecting the aluminum content in sodium bicarbonate Ringer's injection according to claim 5, characterized in that: The dilution mechanism (6) comprises a dilution box (61), the dilution box (61) is connected to the separatory funnel (51) via a liquid outlet pipe (64), and the dilution box (61) is used to transport the diluted liquid to the separatory funnel (51).

7. The device for detecting the aluminum content in sodium bicarbonate Ringer's injection according to claim 6, characterized in that: The dilution box (61) is connected to a liquid inlet pipe (62) and a dilution pipe (63), and flow valves are provided on the liquid inlet pipe (62), the dilution pipe (63) and the liquid outlet pipe (64).

8. The device for detecting the aluminum content in sodium bicarbonate Ringer's injection according to claim 7, characterized in that: The dilution box (61) is equipped with a motor (65), the output shaft of the motor (65) is connected to a stirring frame (66) inside the dilution box (61), and the motor (65) is used to drive the stirring frame (66) to rotate and mix the solution.

9. The device for detecting the aluminum content in sodium bicarbonate Ringer's injection according to claim 8, characterized in that: It also includes a cleaning box (7), wherein the cleaning box (7) is provided with a water pump (71), wherein the water pump (71) is connected to a dilution pipe (63) of a dilution box (61) via a water pipe (72), wherein the water pipe (72) is used to provide dilution liquid and cleaning water to the dilution box (61); The water pump (71) is connected to the platinum crucible (4) via the second water pipe (73), and the platinum crucible (4) is used to provide dissolved water and cleaning water for the platinum crucible (4). Flow valves are provided on the first water pipe (72) and the second water pipe (73).

10. The device for detecting the aluminum content in sodium bicarbonate Ringer's injection according to claim 9, characterized in that: A waste liquid box (8) is arranged on the workbench (1), and the waste liquid box (8) is used to collect waste liquid from the dilution box (61), the separatory funnel (51) and the platinum crucible (4); and a control box (9) is arranged on the workbench (1).

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