Quality online detection device and method for Wuzi Yanzong oral liquid preparation

Abstract

The invention provides an online quality detection device and method for a Wuzi Yanzong oral liquid preparation, and belongs to the technical field of medicine detection and analysis. Comprising four purification devices, a workbench and a spectrum analyzer, the purification devices and the spectrum analyzer are installed on the workbench, and the spectrum analyzer can conduct infrared spectrum analysis on oral liquid in the purification devices. The centrifugal impeller and the fine grating plate are arranged, the centrifugal impeller is driven by the driving motor to rotate at a high speed, the negative pressure machine is connected through the negative suction pipe, and negative pressure is formed in the outer barrel, the inner barrel and the liquid storage barrel; the liquid medicine on the outermost surface in the liquid storage cylinder and a small part of remaining foam are sucked into the bearing top cylinder and the bearing bottom cylinder through the three groups of eduction pipes, so that the phenomenon that the bubbles scatter a light path and interfere spectrum signals when infrared spectrum analysis is carried out on a sample is eliminated, and the problem that the detection result of an existing online detection device is inaccurate is solved.

Description

Technical Field

[0001] The present invention relates to the technical field of drug detection and analysis, and in particular to an online quality detection device and method for a Wuzi Yanzong oral liquid preparation. Background Art

[0002] Wuzi Yanzong oral liquid has the effect of nourishing the kidney and replenishing essence. It is used for sore waist and weak legs, spermatorrhea, premature ejaculation, impotence and infertility. Its main ingredients are: wolfberry, dodder seed (fried), raspberry, schisandra (steamed), and plantain seed (fried with salt). Therefore, Wuzi Yanzong oral liquid needs to be tested for its drug ingredients before it is put on the market to determine whether it meets the listing standards. Traditional testing methods mostly rely on chemical analysis methods, such as using titration to detect the ingredients of the liquid medicine, but this test analysis time is long and it is difficult to ensure product quality. With the development of the times, it has gradually been replaced by spectrometers, chromatographs and other component determination instruments.

[0003] When using a spectrometer to analyze the finished product of the drug solution, since the Wu Zi Yan Zong oral liquid contains some drug residues after it is produced, the drug residues mixed in the drug solution will have a certain impact on the accuracy of the detection. At the same time, the drug solution will contain a large number of bubbles, which will scatter the light path and interfere with the spectral signal. Moreover, at different temperatures, the volume of light scattered by the same drug atoms is also different. Therefore, during detection, it is necessary to eliminate the influence of bubbles, drug residues and temperature. The traditional bubble elimination method usually uses mechanical oscillation defoaming, but this method cannot completely achieve the defoaming effect.

[0004] Therefore, the present application provides an online quality detection device and method for Wuzi Yanzong oral liquid preparation to meet the needs. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide an online quality detection device and method for Wu Zi Yan Zong oral liquid preparations. A centrifugal impeller and a fine grid plate are arranged, the centrifugal impeller is driven by a driving motor to rotate at high speed, and a negative suction pipe is used to connect a negative pressure machine to form negative pressure in an outer cylinder, an inner cylinder and a liquid storage cylinder, and the medicine liquid on the surface of the liquid storage cylinder and a small remaining part of the foam are sucked into a supporting top cylinder and a supporting bottom cylinder through three groups of outlet pipes, thereby eliminating the scattering of the light path by bubbles and interference with the spectral signal when performing infrared spectral analysis of the sample, so as to solve the problem of inaccurate detection results of existing online detection devices.

[0006] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0007] An online quality detection device and method for Wuzi Yanzong oral liquid preparations, comprising a purification device, a workbench and a spectrometer, wherein the purification device is provided with four groups, and the purification device and the spectrometer are both installed on the workbench, and the spectrometer can perform infrared spectrum analysis on the oral liquid in the purification device, a support frame is fixedly installed on the top of the workbench, and the four groups of the purification devices are respectively installed at the four corners of the support frame, and the purification device comprises an extraction component, and also comprises a defoaming component installed on the top of the extraction component;

[0008] The defoaming component includes an outer cylinder, a partition is sealed and fixedly installed on the inner wall at the bottom of the outer cylinder, a liquid inlet pipe is fixedly installed on both side walls in the middle of the outer cylinder, an inner cylinder is fixedly installed at the center of the top of the partition, and the bottom of the inner cylinder seals through the partition, a sealing cylinder is sealed and fixedly connected to the inner wall of the inner cylinder, a fine grid plate is sealed and fixedly connected to the inner wall at the top of the sealing cylinder, a negative suction pipe is opened at the top of the outer cylinder, and a centrifugal mechanism is arranged at the bottom of the inner cylinder.

[0009] Optionally, the centrifugal mechanism includes a load-bearing top cylinder, the top of the load-bearing top cylinder is sealed and fixedly connected to the bottom of the inner cylinder body, the inner wall of the bottom of the load-bearing top cylinder is sealed and fixedly connected to the load-bearing bottom cylinder, the outer wall of the bottom of the load-bearing bottom cylinder is fixedly installed with an outlet pipe, the outlet pipes are provided in three groups and are arranged in a triangle, a protective tube is fixedly installed on the inner wall of the middle part of the load-bearing bottom cylinder, the top of the protective tube seals and penetrates a fine grid plate, the inner wall of the protective tube is rotatably connected to a centrifugal impeller, a motor 1 is fixedly installed on the top of the outer cylinder body, and the output shaft of the motor 1 is fixedly connected to the top rotating rod of the centrifugal impeller, a stabilization frame is connected to the bottom rotating rod of the centrifugal impeller through a bearing sleeve, and the top of the stabilization frame is fixedly connected to the outer wall of the load-bearing top cylinder.

[0010] Optionally, the extraction component includes a liquid storage cylinder, the top of the liquid storage cylinder is sealed and fixedly connected to the bottom of the outer cylinder body, the centrifugal impeller and the outlet pipe are both located in the liquid storage cylinder, and the outlet pipe is in active contact with the inner wall of the liquid storage cylinder, an electric heating wire is fixedly installed on the inner wall of the liquid storage cylinder, a rotating rack is fixedly installed on the outer wall of the liquid storage cylinder, a flap is rotatably connected to the inner wall of the bottom of the liquid storage cylinder, and the flap can be in sealing contact with the inner wall of the liquid storage cylinder, a liquid discharge funnel is sealed and fixedly connected to the inner wall of the bottom of the liquid storage cylinder, and an electromagnetic valve is fixedly installed on the output port at the bottom of the liquid discharge funnel.

[0011] Optionally, a connecting rod 1 is fixedly installed on the flip plate shaft located outside the liquid storage cylinder, and the other end of the connecting rod 1 is rotatably connected to a connecting rod 2, the inner wall of the rotating frame is rotatably connected to a rotating shaft, and a positioning plate 1 and a positioning plate 2 are fixedly installed on the end wall of the rotating shaft, the other end of the connecting rod 2 is rotatably connected to the positioning plate 1, and the outer end wall of the positioning plate 2 is rotatably connected to a push rod.

[0012] Optionally, the outer wall of the liquid storage cylinder is fixedly connected to the support frame, a portal frame is fixedly installed on the top of the support frame, the side walls of the portal frame are rotatably connected to screws, the inner walls on both sides of the portal frame are slidably connected to slide bars, the two groups of slide bar inner walls are fixedly installed with the same connecting rod, the other ends of the four groups of push rods are rotatably connected to the outer wall of the connecting rod, the outer wall of the slide bar on the left side is fixedly installed with an internal thread ring, the internal thread ring is meshed with the screw, and motor 2 is fixedly installed on the top of the portal frame, and the output shaft of motor 2 is fixedly connected to the end wall of the screw.

[0013] Optionally, a detection method of an online quality detection device for Wuzi Yanzong oral liquid preparation also includes the following specific operation steps:

[0014] S1: The tester passes the freshly prepared oral liquid precursor into the four groups of outer cylinders through the liquid inlet pipe. At this time, the oral liquid precursor accumulates on the partition plate, and the drug residue and other solid impurities in the oral liquid precursor will settle at the bottom of the liquid. The liquid on the top of the oral liquid precursor will enter the inner cylinder through the fine grid plate, and the fine grid plate will block the scum floating in the oral liquid;

[0015] S2: The liquid medicine entering the inner cylinder will enter the bottom cylinder through the top cylinder, and at the same time enter the liquid storage cylinder through the three groups of outlet pipes, and the liquid medicine will slowly fall to the bottom of the liquid storage cylinder along the inner wall of the liquid storage cylinder. When the liquid medicine completely falls into the liquid storage cylinder, the drive motor 1 drives the centrifugal impeller to rotate by its output shaft, and the centrifugal effect of the high-speed rotating centrifugal impeller and the sufficiently large impact on the wall of the liquid storage cylinder when rotating are utilized to break the foam and eliminate the foam, thereby eliminating most of the foam in the liquid medicine;

[0016] S3: After eliminating most of the foam in the liquid medicine, the negative suction pipe is used to connect the negative pressure machine, thereby forming negative pressure in the outer cylinder, the inner cylinder and the liquid storage cylinder, and the liquid medicine on the surface of the liquid storage cylinder and the remaining small part of the foam are sucked into the load-bearing top cylinder and the load-bearing bottom cylinder through three groups of outlet pipes. When the liquid medicine and the remaining small part of the foam are sucked into the inner cylinder, they will pass through the fine grid plate. At this time, the negative suction force generated by the negative pressure machine will cause the foam to be compressed and broken by the grid holes on the fine grid plate when passing through the fine grid plate;

[0017] S4: After the foam in the liquid storage cylinder is completely eliminated, the electric heating wires in the four groups of liquid storage cylinders are energized respectively, so that the temperature of the medicine in the four groups of liquid storage cylinders is 10°C, 20°C, 30°C and 40°C respectively. After the medicine in the liquid storage cylinder is kept warm, the second motor is driven to make its output shaft drive the screw to rotate, so that the screw is meshed with the internal thread ring, thereby driving the slide bar and the connecting rod to move, so that the connecting rod drives the push rod to move, and through the transmission action of the connecting rod 1, the connecting rod 2 and the rotating shaft, the flap is deflected, so that the medicine at the bottom of the liquid storage cylinder is discharged into the discharge funnel;

[0018] S5: During the test, the solenoid valves are opened to respectively take out the reagents in the four groups of drainage funnels, and then the reagents in the four groups of drainage funnels are sequentially introduced into the spectrometer for analysis.

[0019] Compared with the prior art, the present invention has at least the following beneficial effects:

[0020] In the above scheme, a centrifugal impeller and a fine grid plate are set, and the centrifugal impeller is driven by a driving motor to rotate at a high speed. The centrifugal effect of the high-speed rotating centrifugal impeller and the sufficiently large impact on the wall of the liquid storage cylinder when rotating are utilized to break up the foam and defoam, thereby eliminating most of the foam in the liquid medicine. Thereafter, a negative pressure machine is connected through a negative suction pipe to form a negative pressure in the outer cylinder, the inner cylinder and the liquid storage cylinder, and the liquid medicine on the surface of the liquid storage cylinder and the remaining small part of the foam are sucked into the supporting top cylinder and the supporting bottom cylinder through three groups of outlet pipes. When the liquid medicine and the remaining small part of the foam are sucked into the inner cylinder, they will pass through the fine grid plate. At this time, the negative suction force generated by the negative pressure machine will cause the foam to be compressed and broken by the grid holes on the fine grid plate when passing through the fine grid plate, thereby eliminating the scattering of the light path by the bubbles and interference with the spectral signal when performing infrared spectroscopy analysis of the sample.

[0021] By setting up four sets of purification devices and electric heating wires, the same sample can be subjected to spectral analysis at 10°C, 20°C, 30°C and 40°C respectively, thereby avoiding inaccurate measurement results of certain drugs at inappropriate temperatures and improving the accuracy of the measurement results. At the same time, the four sets of purification devices can also be used for control experiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the invention and, together with the description, further serve to explain the principles of the invention and to enable those skilled in the relevant art to make and use the invention.

[0023] Figure 1 It is a schematic diagram of the three-dimensional structure of an online quality detection device for Wuzi Yanzong oral liquid preparation;

[0024] Figure 2 It is a schematic diagram of the installation structure of the purification device and the support frame;

[0025] Figure 3 It is a schematic diagram of the structure of the purification device;

[0026] Figure 4 This is a split diagram of the purification device;

[0027] Figure 5 is a cross-sectional view of a defoaming component;

[0028] Figure 6 This is a disassembled diagram of the defoaming component;

[0029] Figure 7 It is a schematic diagram of the installation structure of the centrifugal mechanism in the outer cylinder;

[0030] Figure 8 This is a disassembled diagram of the centrifugal mechanism;

[0031] Fig. 9 It is a schematic diagram of the installation structure of the centrifugal impeller and the protective tube;

[0032] Fig.10 It is a schematic diagram of the structure of the extraction component;

[0033] Fig.11 The figure is a schematic diagram of the installation structure of the flap;

[0034] Fig.12 It is a structural schematic diagram of the external transmission mechanism of the liquid storage cylinder;

[0035] Fig.13 It is a schematic diagram of the installation structure of four sets of liquid storage cylinders and the gantry;

[0036] Fig.14 It is a schematic diagram of the installation structure of various components on the portal frame.

[0037] Reference numerals:

[0038] Purification device 100, defoaming component 110, outer cylinder 111, partition 112, liquid inlet pipe 113, inner cylinder 114, sealing cylinder 115, fine grid plate 116, negative suction pipe 117, centrifugal mechanism 120, load-bearing top cylinder 121, load-bearing bottom cylinder 122, outlet pipe 123, protective pipe 124, centrifugal impeller 125, stabilizing frame 126, motor 127, extraction component 130, liquid storage cylinder 131, Electric heating wire 132, rotating frame 133, flap 134, drainage funnel 135, solenoid valve 136, connecting rod 140, connecting rod 2 141, rotating shaft 142, positioning plate 1 143, positioning plate 2 144, push rod 145, workbench 200, spectrometer 210, supporting frame 220, gantry 230, screw 231, motor 2 232, slide bar 233, connecting rod 234, internal thread ring 235.

[0039] As shown in the figure, in order to clearly implement the structure of the embodiment of the present invention, specific structures and devices are marked in the figure, but this is only for illustrative purposes and is not intended to limit the present invention to the specific structure, device and environment. According to specific needs, ordinary technicians in this field can adjust or modify these devices and environments. DETAILED DESCRIPTION

[0040] The following is a detailed description of an online quality detection device and method for Wuzi Yanzong oral liquid preparation provided by the present invention in conjunction with the accompanying drawings and specific embodiments. At the same time, it is explained here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments, and those skilled in the art may also adopt other alternatives to implement some known technologies; and the accompanying drawings are only for a more specific description of the embodiments, and are not intended to specifically limit the present invention.

[0041] like Figures 1 to 14 As shown, an embodiment of the present invention provides an online quality detection device and method for Wuzi Yanzong oral liquid preparation, including a purification device 100, a workbench 200 and a spectrometer 210. The purification device 100 is provided with four groups, and the purification device 100 and the spectrometer 210 are both installed on the workbench 200. The spectrometer 210 can perform infrared spectroscopy analysis on the oral liquid in the purification device 100. A support frame 220 is fixedly installed on the top of the workbench 200. Four groups of purification devices 100 are respectively installed at the four corners of the support frame 220. The purification device 100 includes an extraction component 130 and also includes a defoaming component 110 installed on the top of the extraction component 130. In the present invention, when using the spectrometer 210 to analyze the composition of the drug, it is necessary to create a suitable liquid pool. The window material of the liquid pool is generally sodium chloride, potassium bromide or calcium fluoride, etc. These materials have good light transmittance when performing infrared analysis. After the defoamed liquid sample in the purification device 100 is injected into the liquid pool, it is analyzed by the spectrometer 210;

[0042] The defoaming component 110 includes an outer cylinder 111, a partition 112 is sealed and fixedly installed on the inner wall at the bottom of the outer cylinder 111, a liquid inlet pipe 113 is fixedly installed on both side walls of the middle of the outer cylinder 111, an inner cylinder 114 is fixedly installed at the center of the top of the partition 112, and the bottom of the inner cylinder 114 is sealed and penetrates the partition 112, a sealing cylinder 115 is sealed and fixedly connected to the inner wall of the inner cylinder 114, and a fine grid plate 116 is sealed and fixedly connected to the inner wall of the top of the sealing cylinder 115, a negative suction pipe 117 is opened at the top of the outer cylinder 111, and a centrifugal mechanism 120 is arranged at the bottom of the inner cylinder 114. In the present invention, after most of the foam in the liquid is eliminated, a negative pressure machine is connected through the negative suction pipe 117, so that negative pressure is formed in the outer cylinder 111, the inner cylinder 114 and the liquid storage cylinder 131, and the liquid storage cylinder 131 is filled with liquid. The medicine liquid on the surface and the remaining small part of the foam are sucked into the supporting top cylinder 121 and the supporting bottom cylinder 122 through three groups of outlet pipes 123. After the medicine liquid and the remaining small part of the foam are sucked into the inner cylinder 114, they will pass through the fine grid plate 116. At this time, the negative suction force generated by the negative pressure machine will cause the foam to be compressed and broken by the grid holes on the fine grid plate 116 when passing through the fine grid plate 116. In particular, the oral liquid precursor to be tested is introduced into the four groups of outer cylinders 111 through the liquid inlet pipe 113, and the oral liquid precursor is accumulated on the partition 112. The medicine residue and other solid impurities in the oral liquid precursor will settle at the bottom of the medicine liquid, and the medicine liquid at the top of the oral liquid precursor will enter the inner cylinder 114 through the fine grid plate 116, and the fine grid plate 116 will block the scum floating in the oral liquid.

[0043] As an implementation method in this embodiment, Figures 7 to 9 As shown, the centrifugal mechanism 120 includes a load-bearing top cylinder 121, the top of the load-bearing top cylinder 121 is sealed and fixedly connected to the bottom of the inner cylinder 114, the inner wall of the bottom of the load-bearing top cylinder 121 is sealed and fixedly connected to the load-bearing bottom cylinder 122, the outer wall of the bottom of the load-bearing bottom cylinder 122 is fixedly installed with an outlet pipe 123, and the outlet pipe 123 is provided with three groups and arranged in a triangular shape, and the inner wall of the middle part of the load-bearing bottom cylinder 122 is fixedly installed with a protective pipe 124, which provides protection for the rotating shaft of the centrifugal impeller 125, and at the same time It also serves to stabilize the rotation of the centrifugal impeller 125. The top seal of the protective tube 124 passes through the fine grid plate 116. The inner wall of the protective tube 124 is rotatably connected to the centrifugal impeller 125. A motor 127 is fixedly installed on the top of the outer cylinder 111, and the output shaft of the motor 127 is fixedly connected to the top rotating rod of the centrifugal impeller 125. A stabilizing frame 126 is connected to the bottom rotating rod of the centrifugal impeller 125 through a bearing sleeve, and the top of the stabilizing frame 126 is fixedly connected to the outer wall of the load-bearing top cylinder 121.

[0044] As an implementation method in this embodiment, Figures 6 to 10As shown, the extraction component 130 includes a liquid storage cylinder 131, the top of the liquid storage cylinder 131 is sealed and fixedly connected to the bottom of the outer cylinder body 111, the centrifugal impeller 125 and the outlet pipe 123 are both located in the liquid storage cylinder 131, and the outlet pipe 123 is in active contact with the inner wall of the liquid storage cylinder 131, the inner wall of the liquid storage cylinder 131 is fixedly installed with an electric heating wire 132, the outer wall of the liquid storage cylinder 131 is fixedly installed with a rotating frame 133, the inner wall of the bottom of the liquid storage cylinder 131 is rotatably connected with a flap 134, and the flap 134 can be in sealed contact with the inner wall of the liquid storage cylinder 131, the inner wall of the bottom of the liquid storage cylinder 131 is sealed and fixedly connected with a discharge funnel 135, and the bottom output port of the discharge funnel 135 is fixedly installed with an electromagnetic valve 136. In the present invention, the medicine liquid entering the inner cylinder body 114 will enter the bearing bottom cylinder 122 through the bearing top cylinder 121, and at the same time pass through the three groups of outlet pipes 123 to enter the liquid storage cylinder 131, and the medicine liquid will slowly fall along the inner wall of the liquid storage cylinder 131 to the bottom of the liquid storage cylinder 131, thereby reducing the generation of bubbles in the medicine liquid during the descent process. When the medicine liquid completely falls into the liquid storage cylinder 131, the driving motor 127 makes its output shaft drive the centrifugal impeller 125 to rotate, and utilizes the centrifugal effect of the high-speed rotating centrifugal impeller 125 and the sufficiently large impact on the wall of the liquid storage cylinder 131 when rotating, so that the foam is broken and defoamed, thereby eliminating most of the foam in the medicine liquid.

[0045] In this embodiment, if Figures 11 to 14As shown, a connecting rod 140 is fixedly installed on the rotating shaft of the flap 134 located outside the liquid storage cylinder 131, and the other end of the connecting rod 140 is rotatably connected to the connecting rod 2 141, the inner wall of the rotating frame 133 is rotatably connected to the rotating shaft 142, and the end wall of the rotating shaft 142 is fixedly installed with a positioning plate 143 and a positioning plate 2 144, the other end of the connecting rod 2 141 is rotatably connected to the positioning plate 143, and the outer end wall of the positioning plate 2 144 is rotatably connected to the push rod 145, and the outer wall of the liquid storage cylinder 131 is fixedly connected to the support frame 220. Next, the support frame 220 supports the liquid storage cylinder 131, and a gantry frame 230 is fixedly installed on the top of the support frame 220. The gantry frame 230 is located in the middle of the four groups of liquid storage cylinders 131. The side wall of the gantry frame 230 is rotatably connected with a screw 231. The inner walls of both sides of the gantry frame 230 are slidably connected with slide bars 233. The inner walls of the two groups of slide bars 233 are fixedly installed with the same connecting rod 234. The other ends of the four groups of push rods 145 are rotatably connected to the outer wall of the connecting rod 234. The outer wall of the left slide bar 233 is fixedly installed with a The inner thread ring 235 is meshed with the screw rod 231. The motor 232 is fixedly installed on the top of the gantry 230, and the output shaft of the motor 232 is fixedly connected to the end wall of the screw rod 231. In the present invention, after the foam in the liquid storage cylinder 131 is completely eliminated, the electric heating wires 132 in the four groups of liquid storage cylinders 131 are energized respectively, so that the temperature of the medicine in the four groups of liquid storage cylinders 131 is 10°C, 20°C, 30°C and 40°C respectively, and the heat preservation of the medicine in the liquid storage cylinder 131 is completed. Afterwards, the output shaft of the driving motor 232 drives the screw 231 to rotate, so that the screw 231 engages with the internal thread ring 235, thereby driving the slide bar 233 and the connecting rod 234 to move, so that the connecting rod 234 drives the push rod 145 to move, thereby driving the rotating shaft 142 to rotate, driving the connecting rod 2 141 to rotate, and under the linkage action of the connecting rod 1 140, the flap 134 is deflected, so that the medicine at the bottom of the liquid storage cylinder 131 is discharged into the liquid discharge funnel 135.

[0046] The detection scheme of the technical solution provided by the present invention is as follows:

[0047] S1: The tester introduces the freshly prepared oral liquid precursor to be tested into the four sets of outer cylinders 111 through the liquid inlet pipe 113. At this time, the oral liquid precursor is accumulated on the partition 112, and the drug residue and other solid impurities in the oral liquid precursor will settle at the bottom of the drug liquid. The drug liquid at the top of the oral liquid precursor will enter the inner cylinder 114 through the fine grid plate 116, and the fine grid plate 116 will block the scum floating in the oral liquid;

[0048] S2: The liquid medicine entering the inner cylinder 114 will enter the bottom cylinder 122 through the top cylinder 121, and at the same time enter the liquid storage cylinder 131 through the three groups of outlet pipes 123, and the liquid medicine will slowly fall to the bottom of the liquid storage cylinder 131 along the inner wall of the liquid storage cylinder 131. When the liquid medicine completely falls into the liquid storage cylinder 131, the drive motor 127 drives its output shaft to drive the centrifugal impeller 125 to rotate, and the centrifugal effect of the high-speed rotating centrifugal impeller 125 and the sufficiently large impact on the wall of the liquid storage cylinder 131 when they rotate are utilized to break the foam and eliminate the foam, thereby eliminating most of the foam in the liquid medicine;

[0049] S3: After eliminating most of the foam in the liquid medicine, the negative pressure machine is connected through the negative suction pipe 117, so as to form negative pressure in the outer cylinder 111, the inner cylinder 114 and the liquid storage cylinder 131, and the liquid medicine on the surface of the liquid storage cylinder 131 and the remaining small part of the foam are sucked into the bearing top cylinder 121 and the bearing bottom cylinder 122 through the three groups of outlet pipes 123. When the liquid medicine and the remaining small part of the foam are sucked into the inner cylinder 114, they will pass through the fine grid plate 116. At this time, the negative suction force generated by the negative pressure machine will cause the foam to be compressed by the grid holes on the fine grid plate 116 until it bursts when passing through the fine grid plate 116;

[0050] S4: After the foam in the liquid storage cylinder 131 is completely eliminated, the electric heating wires 132 in the four groups of liquid storage cylinders 131 are energized respectively, so that the temperature of the medicine in the four groups of liquid storage cylinders 131 is 10°C, 20°C, 30°C and 40°C respectively. After the medicine in the liquid storage cylinder 131 is kept warm, the second motor 232 is driven to make its output shaft drive the screw 231 to rotate, so that the screw 231 is engaged with the internal thread ring 235, thereby driving the slide bar 233 and the connecting rod 234 to move, so that the connecting rod 234 drives the push rod 145 to move, and through the transmission action of the connecting rod 140, the connecting rod 241 and the rotating shaft 142, the flap 134 is deflected, so that the medicine at the bottom of the liquid storage cylinder 131 is discharged into the discharge funnel 135;

[0051] S5: During the detection, the solenoid valve 136 is opened to respectively take out the medicines in the four groups of drainage funnels 135, and then the medicines in the four groups of drainage funnels 135 are sequentially introduced into the spectrometer 210 for analysis.

[0052] The present invention covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present invention. In order to make the public have a thorough understanding of the present invention, specific details are described in detail in the following preferred embodiments of the present invention, but those skilled in the art can fully understand the present invention without the description of these details. In addition, in order to avoid unnecessary confusion about the essence of the present invention, well-known methods, processes, procedures, components and circuits are not described in detail.

[0053] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An online quality detection device for Wuzi Yanzong oral liquid preparation, comprising a purification device (100), a workbench (200) and a spectrometer (210), wherein the purification device (100) is provided with four groups, and the purification device (100) and the spectrometer (210) are both installed on the workbench (200), and the spectrometer (210) can perform infrared spectroscopy analysis on the oral liquid in the purification device (100), characterized in that: A support frame (220) is fixedly mounted on the top of the workbench (200), and four groups of purification devices (100) are respectively mounted at four corners of the support frame (220), and the purification device (100) includes an extraction component (130) and a defoaming component (110) mounted on the top of the extraction component (130); The defoaming component (110) comprises an outer cylinder (111), a partition (112) is sealed and fixedly mounted on the inner wall at the bottom of the outer cylinder (111), a liquid inlet pipe (113) is fixedly mounted on both side walls in the middle of the outer cylinder (111), an inner cylinder (114) is fixedly mounted at the center of the top of the partition (112), and the bottom of the inner cylinder (114) seals and penetrates the partition (112), a sealing cylinder (115) is sealed and fixedly mounted on the inner wall of the inner cylinder (114), a fine grid plate (116) is sealed and fixedly mounted on the inner wall at the top of the sealing cylinder (115), a negative suction pipe (117) is opened at the top of the outer cylinder (111), and a centrifugal mechanism (120) is arranged at the bottom of the inner cylinder (114).

2. The online quality detection device for Wuzi Yanzong oral liquid preparation according to claim 1, characterized in that: The centrifugal mechanism (120) comprises a load-bearing top cylinder (121), the top of the load-bearing top cylinder (121) is sealed and fixedly connected to the bottom of the inner cylinder (114), the bottom inner wall of the load-bearing top cylinder (121) is sealed and fixedly connected to a load-bearing bottom cylinder (122), the bottom outer wall of the load-bearing bottom cylinder (122) is fixedly installed with an outlet pipe (123), the outlet pipe (123) is provided in three groups and arranged in a triangular shape, the middle inner wall of the load-bearing bottom cylinder (122) is fixedly installed with a protective pipe (124), the protective pipe The top seal (124) penetrates the fine grid plate (116); the inner wall of the protective tube (124) is rotatably connected to a centrifugal impeller (125); a motor (127) is fixedly installed on the top of the outer cylinder (111); and the output shaft of the motor (127) is fixedly connected to the top rotating rod of the centrifugal impeller (125); a stabilizing frame (126) is connected to the bottom rotating rod of the centrifugal impeller (125) through a bearing sleeve; and the top of the stabilizing frame (126) is fixedly connected to the outer wall of the load-bearing top cylinder (121).

3. The online quality detection device for Wuzi Yanzong oral liquid preparation according to claim 2, characterized in that: The extraction assembly (130) comprises a liquid storage cylinder (131), the top of the liquid storage cylinder (131) is sealed and fixedly connected to the bottom of the outer cylinder (111), the centrifugal impeller (125) and the outlet pipe (123) are both located in the liquid storage cylinder (131), and the outlet pipe (123) is in active contact with the inner wall of the liquid storage cylinder (131), the inner wall of the liquid storage cylinder (131) is fixedly mounted with an electric heating wire (132), the outer wall of the liquid storage cylinder (131) is fixedly mounted with a rotating frame (133), the inner wall of the bottom of the liquid storage cylinder (131) is rotatably connected with a flap (134), and the flap (134) can be in sealed contact with the inner wall of the liquid storage cylinder (131), the inner wall of the bottom of the liquid storage cylinder (131) is sealed and fixedly connected with a liquid discharge funnel (135), and the bottom output port of the liquid discharge funnel (135) is fixedly mounted with a solenoid valve (136).

4. The online quality detection device for Wuzi Yanzong oral liquid preparation according to claim 3, characterized in that: A connecting rod 1 (140) is fixedly installed on the rotating shaft of the flap (134) located outside the liquid storage cylinder (131), and the other end of the connecting rod 1 (140) is rotatably connected to a connecting rod 2 (141). The inner wall of the rotating frame (133) is rotatably connected to a rotating shaft (142), and a positioning plate 1 (143) and a positioning plate 2 (144) are fixedly installed on the end wall of the rotating shaft (142). The other end of the connecting rod 2 (141) is rotatably connected to the positioning plate 1 (143), and the outer end wall of the positioning plate 2 (144) is rotatably connected to a push rod (145).

5. The online quality detection device for Wuzi Yanzong oral liquid preparation according to claim 4, characterized in that: The outer wall of the liquid storage cylinder (131) is fixedly connected to the support frame (220), a portal frame (230) is fixedly installed on the top of the support frame (220), the side wall of the portal frame (230) is rotatably connected to a screw rod (231), the inner walls on both sides of the portal frame (230) are slidably connected to slide bars (233), the inner walls of two groups of the slide bars (233) are fixedly installed with the same connecting rod (234), the other ends of the four groups of push rods (145) are rotatably connected to the outer wall of the connecting rod (234), the outer wall of the slide bar (233) on the left side is fixedly installed with an internal thread ring (235), the internal thread ring (235) is meshed with the screw rod (231), and the top of the portal frame (230) is fixedly installed with a second motor (232), and the output shaft of the second motor (232) is fixedly connected to the end wall of the screw rod (231).

6. The detection method of the online quality detection device of Wuzi Yanzong oral liquid preparation according to claim 5, characterized in that: The specific steps are as follows: S1: The testing personnel pass the freshly prepared oral liquid precursor to be tested into the four groups of outer cylinders (111) through the liquid inlet pipe (113). At this time, the oral liquid precursor is accumulated on the partition (112), and the drug residue and other solid impurities in the oral liquid precursor will settle at the bottom of the drug liquid. The drug liquid at the top of the oral liquid precursor will enter the inner cylinder (114) through the fine grid plate (116), and the fine grid plate (116) will block the scum floating in the oral liquid. S2: The liquid medicine that enters the inner cylinder (114) will enter the bearing bottom cylinder (122) through the bearing top cylinder (121), and at the same time pass through the three groups of outlet pipes (123) to enter the liquid storage cylinder (131), and the liquid medicine will slowly fall along the inner wall of the liquid storage cylinder (131) to the bottom of the liquid storage cylinder (131). When the liquid medicine completely falls into the liquid storage cylinder (131), the driving motor 1 (127) causes its output shaft to drive the centrifugal impeller (125) to rotate, and the centrifugal effect of the high-speed rotating centrifugal impeller (125) and the sufficiently large impact on the wall of the liquid storage cylinder (131) when they rotate are utilized to break the foam and eliminate the foam, thereby eliminating most of the foam in the liquid medicine; S3: After eliminating most of the foam in the liquid medicine, a negative pressure machine is connected through a negative suction pipe (117), thereby forming a negative pressure in the outer cylinder (111), the inner cylinder (114) and the liquid storage cylinder (131), and the liquid medicine on the surface of the liquid storage cylinder (131) and the remaining small part of the foam are sucked into the load-bearing top cylinder (121) and the load-bearing bottom cylinder (122) through three groups of outlet pipes (123). After the liquid medicine and the remaining small part of the foam are sucked into the inner cylinder (114), they will pass through the fine grid plate (116). At this time, the negative suction force generated by the negative pressure machine will cause the foam to be compressed by the grid holes on the fine grid plate (116) until it bursts when passing through the fine grid plate (116); S4: After the foam in the liquid storage cylinder (131) is completely eliminated, the electric heating wires (132) in the four groups of liquid storage cylinders (131) are energized respectively, so that the temperature of the medicine in the four groups of liquid storage cylinders (131) is 10° C., 20° C., 30° C. and 40° C. respectively. After the medicine in the liquid storage cylinder (131) is kept warm, the second motor (232) is driven to make its output shaft drive the screw rod (231) to rotate, so that the screw rod (231) is meshed with the internal thread ring (235), thereby driving the slide bar (233) and the connecting rod (234) to move, so that the connecting rod (234) drives the push rod (145) to move, and through the transmission action of the connecting rod 1 (140), the connecting rod 2 (141) and the rotating shaft (142), the flap (134) is deflected, so that the medicine at the bottom of the liquid storage cylinder (131) is discharged into the discharge funnel (135); S5: During the detection, the solenoid valve (136) is opened to respectively take out the medicines in the four groups of drainage funnels (135), and then the medicines in the four groups of drainage funnels (135) are sequentially introduced into the spectrometer (210) for analysis.

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