Soft capsule dissolution detection device with self-cleaning function

Abstract

The invention discloses a soft capsule dissolution detection device with a self-cleaning function, the detection device comprises a tank body, an outer frame, an evaluation mechanism, a stirring mechanism, a cleaning mechanism, an aeration mechanism and a detection mechanism, the evaluation mechanism comprises an upper sample frame, the stirring mechanism comprises a lock pin disc, a first side frame and a layering mechanism, and the upper sample frame is fixedly connected with the lock pin disc; the layering mechanism is connected with the detection mechanism through a pipeline, the tank body is provided with an upper edge and aeration holes, the cleaning mechanism comprises an outer concave ring and a third motor, the outer frame is fixedly connected with the tank body, the aeration mechanism and the detection mechanism, the aeration holes are fixedly connected with the aeration mechanism, the first side frame and the third motor are fixedly connected with the upper edge, and the outer concave ring is rotationally connected with the upper edge; the invention relates to the technical field of capsule detection devices, samples of different prescriptions and processes can be distinguished and evaluated, the capsule content precipitation condition fits the reality through the simulated stomach bag wriggling effect, and rapid self-cleaning can be achieved.

Description

Technical Field

[0001] The invention relates to the technical field of capsule detection devices, in particular to a dissolution detection device for soft capsules with a self-cleaning function. Background Art

[0002] The main ingredient of idecalcitol soft capsules, idecalcitol, is a derivative of active vitamin D3 (calcitriol), which has the pharmacological properties of calcitriol, mainly inhibiting bone metabolism conversion and improving bone density and bone strength. The soft capsules contain a colorless, clear, slightly viscous liquid. Idecalcitol soft capsules are internationally recognized as a new generation of active vitamin D analogs used to treat osteoporosis. The contents of idecalcitol soft capsules are mainly oil and the main ingredient idecalcitol. The oil can be different oils such as soybean oil, peanut oil, and medium-chain oil.

[0003] Different oils diffuse and absorb differently in the body, thus causing different absorption of idecalciferol in the body. Therefore, it is very necessary to find a method for evaluating the dissolution and diffusion of idecalciferol in vitro. In the existing dissolution devices, most of them are mixed liquids sampled by stirring the test tubes. When sampling, it is not possible to accurately sample and compare the different liquid layers of the mixed liquid. At the same time, the dissolution equipment is not cleaned properly, which interferes with the subsequent dissolution test and causes deviations in the test results. Summary of the invention

[0004] The object of the present invention is to provide a dissolution detection device for soft capsules with a self-cleaning function to solve the problems in the prior art.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a dissolution detection device for soft capsules with a self-cleaning function comprises a tank body, an outer frame, an evaluation mechanism, a stirring mechanism, a cleaning mechanism, an aeration mechanism and a detection mechanism, the evaluation mechanism comprises an upper sample rack, the stirring mechanism comprises a locking pin disk, a first side frame and a stratification mechanism, the upper sample rack is fixedly connected to the locking pin disk, the stratification mechanism is connected to the detection mechanism through a pipeline, an upper edge and an aeration hole are provided on the tank body, the cleaning mechanism comprises an outer concave ring and a third motor, the outer frame is fixedly connected to the tank body, the aeration mechanism and the detection mechanism, the aeration hole is fixedly connected to the aeration mechanism, the first side frame and the third motor are fixedly connected to the upper edge, and the outer concave ring is rotatably connected to the upper edge.

[0006] The present invention discloses a detection device for detecting the dissolved contents of a soft capsule. The soft capsule is placed in an evaluation mechanism, medium water is injected into a tank body, a stirring mechanism outputs a fixed-axis torque to be assembled on a sample rack through a locking pin disk, the evaluation mechanism rotates the capsule on a fixed axis in the tank body to release the contents, a stratification mechanism draws mixed liquid of different water layers in the tank body into the detection mechanism for detection, a cleaning mechanism cleans the inner wall of the tank body and the surface of the evaluation mechanism to separate the oil body and the medium water, and an aeration mechanism accelerates the separation speed of the oil body and the medium water.

[0007] Furthermore, the evaluation mechanism also includes a lower sample rack, a gasket and a filter membrane. The upper sample rack is provided with an external thread, and the lower sample rack is provided with a first internal thread and a bottom hole. The external thread and the first internal thread are connected by threads. The bottom hole is arranged on the lower sample rack away from one end of the upper sample rack, and the gasket is in contact with the lower sample rack and the filter membrane.

[0008] The diameter of the filter membrane is larger than the diameter of the lower sample rack. The gasket and the filter membrane are placed on the bottom hole of the lower sample rack. An appropriate amount of soft capsules are placed on the filter membrane. The lower sample rack is assembled with the upper sample rack through a threaded connection between an external thread and a first internal thread. The fixed axis torque is transmitted through the upper sample rack, and the capsule contents are precipitated from the filter membrane under the action of rotation.

[0009] Furthermore, the stirring mechanism also includes a first motor, a gear rod and a center rod, the center rod is fixedly connected to the locking pin disk, the first motor is fixedly connected to the first side frame, the output end of the first motor is fixedly connected to the gear rod, the center rod is provided with a first ring tooth groove and a liquid extraction hole, the gear rod is meshed with the tooth surface of the first ring tooth groove, the layered mechanism includes a top cylinder and an inner cylinder, the center rod is rotatably connected to the top cylinder, the center rod is slidably connected to the inner cylinder, the inner cylinder is provided with a liquid inlet hole, the liquid extraction hole is provided at one end of the center rod away from the top cylinder, several groups of liquid extraction holes and liquid inlet holes are provided, several groups of liquid extraction holes and liquid inlet holes are linearly evenly distributed along the axis of the center rod, the liquid extraction holes are in contact with the liquid inlet holes, the top cylinder is provided with a side hole, the detection mechanism is provided with a liquid extraction pump, and the side hole is connected to the liquid extraction pump through a pipeline.

[0010] The first motor outputs a fixed-axis torque to the gear rod, which meshes with the tooth surface between the first ring tooth grooves on the middle rod through the gear rod. The middle rod and the top cylinder are rotatably assembled, and the gear rod transmits the fixed-axis torque to the middle rod. The middle rod is equipped with a locking pin disk to drive the upper sample rack to rotate on the fixed axis. After the capsule content is precipitated, the liquid extraction pump extracts the mixed liquid into the inner cylinder through the liquid extraction hole and the liquid inlet hole. Through a plurality of groups of liquid extraction holes linearly evenly distributed along the axis of the middle rod and located in different liquid layers of the medium water, the mixed liquids of different liquid layers can be directionally extracted for detection and comparative analysis.

[0011] Furthermore, the stratification mechanism also includes a second motor and a threaded rod, a top hole is also provided on the top cylinder, the second motor is fixedly connected to the top cylinder, the output end of the second motor is fixedly connected to the threaded rod, the threaded rod is rotatably connected to the top hole, a second internal thread and a liquid outlet are provided on the inner cylinder, the second internal thread is threadedly connected to the threaded rod, the inner cylinder and the top cylinder are slidably connected, the liquid outlet is in contact with the side hole, a plurality of groups of liquid outlets are provided, the liquid outlets are provided at one end of the inner cylinder away from the liquid extraction hole, and the plurality of groups of liquid outlets are linearly evenly distributed along the axis of the inner cylinder.

[0012] The liquid pump draws the mixed liquid into the inner cylinder through the liquid extraction hole and the liquid inlet hole, and the mixed liquid is extracted out of the inner cylinder through the liquid outlet hole and the side hole. When adjusting the sampling stratification, the second motor outputs a fixed-axis torque to the threaded rod, and through the threaded connection between the threaded rod and the second internal thread on the inner cylinder, the inner cylinder is moved back and forth up and down in the top cylinder and the middle through rod, and the mixed liquid enters the inner cylinder from the corresponding liquid inlet hole at the bottom through the liquid extraction holes and liquid inlet holes linearly evenly distributed along the axis of the inner cylinder, that is, the displacement position of the liquid inlet hole at the bottom is the liquid layer of the sampled mixed liquid.

[0013] Furthermore, the cleaning mechanism also includes a first gear, a second side frame, an expansion and contraction mechanism and a servo motor. The output end of the third motor is fixedly connected to the first gear. The outer concave ring is provided with a second ring tooth groove and a groove. The first gear is meshed with the tooth surface of the second ring tooth groove. The expansion and contraction mechanism includes a gear column and a rack. The grooves, gear columns and racks are provided with several groups. The several groups of grooves, gear columns and racks are evenly distributed along the circumference of the outer concave ring. The second side frame is fixedly connected to the servo motor and the outer concave ring. The output end of the servo motor is fixedly connected to a group of gear columns, and the rack is slidably connected to the groove.

[0014] When the middle rod rotates on a fixed axis and the capsule contents are precipitated, the third motor outputs a fixed axis torque to the first gear, and the first gear meshes with the second ring tooth surface on the outer concave ring to transmit the torque to the outer concave ring. The outer concave ring rotates around its axis and drives the expansion and contraction mechanism to stir the tank body, simulating the movement of the human stomach to make the capsule contents precipitate in accordance with reality. After the dissolution is completed, the outer concave ring continues to rotate to drive the medium to clean the inner wall of the tank and the surface of the evaluation mechanism. Through the principle of centrifugation, the density of the medium water and the content oil body is different. Under the effect of centrifugation, the content oil body is gathered to the center of the vortex, achieving the effect of oil-water separation and self-cleaning.

[0015] Furthermore, the expansion and contraction mechanism also includes an inner concave ring and fan blades. The inner concave ring contacts the outer concave ring, the tooth column is rotatably connected to the inner concave ring, an inner ring tooth pair is provided on the inner concave ring, the tooth surfaces of the tooth column, the rack and the inner ring tooth pair are all meshed, the fan blades are provided in several groups, the fan blades are fixedly connected to the rack, and the several groups of fan blades are evenly distributed along the circumference of the inner concave ring.

[0016] The outer concave ring rotates around its axis, and the servo motor outputs a fixed-axis torque to a group of tooth columns. The tooth columns rotate on the inner concave ring, and the tooth surfaces between the tooth columns and the inner ring tooth pair on the inner concave ring mesh. The inner concave ring rotates in the outer concave ring and transmits the torque to several groups of tooth columns evenly distributed on the circumference. The tooth surfaces between the tooth columns and the rack mesh, and the transmitted torque causes the rack to move back and forth in the groove. While the several groups of racks evenly distributed on the circumference drive the fan blades to rotate, the radius of the virtual circle formed is constantly changing, which has the effect of simulating the peristalsis of the stomach bag, so that the precipitation of the capsule contents is in line with reality. At the same time, the medium water is driven to self-clean, and the virtual circle formed by the fan blades is constantly expanding and shrinking, so that the stirring vortex force is constantly changing, which can effectively clean the inner wall of the tank and the surface of the evaluation mechanism.

[0017] Furthermore, the aeration mechanism is provided with a ring pipe and an aeration tank, the aeration tank is fixedly connected to the outer frame, aeration holes are provided in a plurality of groups, the plurality of aeration holes are evenly distributed along the circumference of the tank body, and the ring pipe is connected with the aeration holes and the aeration tank through pipelines.

[0018] When the outer concave ring drives the fan blades to rotate for cleaning, the aeration tank aerates the tank body through the ring pipe and aeration holes, introducing a large number of tiny bubbles, causing the hydrophobic oil particles to adhere to the bubbles and float to the water surface with the bubbles, thereby accelerating the separation of oil and water and improving the cleaning effect.

[0019] Furthermore, the detection mechanism also includes a detection instrument, and the liquid pump and the detection instrument are both fixedly connected to the external frame, and the liquid pump and the detection instrument are connected through a pipeline.

[0020] The liquid pump draws the mixed liquid into the inner cylinder through the liquid extraction hole and the liquid inlet hole, and the mixed liquid is drawn out of the inner cylinder through the liquid outlet hole and the side hole and enters the detector for analysis and detection.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows: the present invention designs an evaluation mechanism, the diameter of the filter membrane is larger than the diameter of the lower sample holder, a proper amount of soft capsules are placed on the filter membrane, a fixed-axis torque is transmitted through the upper sample holder, the capsule contents are precipitated from the filter membrane under the action of rotation, and the difference in viscosity of oil bodies with different contents is used to diffuse through the membrane at different speeds, and the contents made of different oils are compared to reflect different diffusion speeds and release amounts, thereby distinguishing and evaluating samples with different prescriptions and processes; the present invention designs a stirring mechanism, and a liquid pump draws the mixed liquid into the inner cylinder through the liquid drawing hole and the liquid inlet hole, and a plurality of groups of liquid drawing holes linearly and evenly distributed along the axis of the middle through rod are located in different liquid layers of the medium water, so that the mixed liquids of different liquid layers can be directionally drawn for detection and comparative analysis; the present invention designs a stirring mechanism, and the liquid pump draws the mixed liquid into the inner cylinder through the liquid drawing hole and the liquid inlet hole, and a plurality of groups of liquid drawing holes linearly and evenly distributed along the axis of the middle through rod are located in different liquid layers of the medium water, so that the mixed liquids of different liquid layers can be directionally drawn for detection and comparative analysis; The invention designs a cleaning mechanism, which drives the fan blades to rotate by a plurality of groups of racks evenly distributed on the circumference. At the same time, the radius of the virtual circle formed is constantly changing, which has the effect of simulating the peristalsis of the stomach bag, so that the precipitation of the capsule contents is in line with reality, and at the same time drives the medium water to self-clean. Through the principle of centrifugation, the density of the medium water and the content oil body is different. Under the effect of centrifugation, the content oil body is gathered to the center of the vortex, so as to achieve the effect of oil-water separation and self-cleaning. The virtual circle formed by the fan blades is constantly expanding and shrinking, so that the stirring vortex force is constantly changing, which can effectively clean the inner wall of the tank and the surface of the evaluation mechanism; the present invention can distinguish and evaluate samples with different prescriptions and processes, and through the effect of simulating the peristalsis of the stomach bag, the precipitation of the capsule contents is in line with reality, and it can be quickly self-cleaned. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0023] Figure 2 It is a partial cross-sectional view of the overall structure of the present invention;

[0024] Figure 3 It is a schematic diagram of the structure of the evaluation mechanism of the present invention;

[0025] Figure 4 It is a partial cross-sectional view of the stirring mechanism of the present invention;

[0026] Figure 5 A partial cross-sectional view of the layered structure of the present invention;

[0027] Figure 6 It is a schematic diagram of the cleaning mechanism structure of the present invention;

[0028] Figure 7 It is a schematic diagram of the expansion and contraction mechanism structure of the present invention;

[0029] Figure 8 It is a schematic diagram of the aeration mechanism structure of the present invention.

[0030] In the figure: 1, tank body; 11, upper edge; 12, aeration hole; 2, outer frame; 3, evaluation mechanism; 31, upper sample rack; 311, external thread; 32, lower sample rack; 321, first internal thread; 322, bottom hole; 33, gasket; 34, filter membrane; 4, stirring mechanism; 41, locking plate; 42, first side frame; 43, first motor; 44, gear rod; 45, middle rod; 451, first ring tooth groove; 452, liquid extraction hole; 46, layering mechanism; 461, top cylinder; 4611, top hole; 4612, side hole; 462, second motor; 463, Threaded rod; 464, inner tube; 4641, second inner thread; 4642, liquid inlet; 4643, liquid outlet; 5, cleaning mechanism; 51, outer concave ring; 511, second ring tooth groove; 512, groove; 52, third motor; 53, first gear; 54, second side frame; 55, expansion and contraction mechanism; 551, inner concave ring; 5511, inner ring gear pair; 552, fan blade; 553, gear column; 554, rack; 56, servo motor; 6, aeration mechanism; 61, ring tube; 62, aeration tank; 7, detection mechanism; 71, liquid pump; 72, detector. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] like Figure 1 , Figure 2As shown, the present invention provides a technical solution of a dissolution detection device for soft capsules with a self-cleaning function, including a tank body 1, an outer frame 2, an evaluation mechanism 3, a stirring mechanism 4, a cleaning mechanism 5, an aeration mechanism 6 and a detection mechanism 7, wherein the evaluation mechanism 3 includes an upper sample rack 31, the stirring mechanism 4 includes a locking disk 41, a first side frame 42 and a stratification mechanism 46, the upper sample rack 31 is fixedly connected to the locking disk 41, the stratification mechanism 46 is connected to the detection mechanism 7 through a pipeline, an upper edge 11 and an aeration hole 12 are provided on the tank body 1, the cleaning mechanism 5 includes an outer concave ring 51 and a third motor 52, the outer frame 2 is fixedly connected to the tank body 1, the aeration mechanism 6 and the detection mechanism 7, the aeration hole 12 is fixedly connected to the aeration mechanism 6, the first side frame 42 and the third motor 52 are fixedly connected to the upper edge 11, and the outer concave ring 51 is rotatably connected to the upper edge 11.

[0033] The present invention is a detection device for detecting the dissolved contents of a soft capsule. The soft capsule is placed in an evaluation mechanism 3, medium water is injected into a tank body 1, a stirring mechanism 4 outputs a fixed-axis torque to be assembled on a sample rack 31 through a locking pin disk 41, the evaluation mechanism 3 rotates the capsule on a fixed axis in the tank body 1 to release the contents, a stratification mechanism 46 draws mixed liquid of different water layers in the tank body 1 to a detection mechanism 7 for detection, a cleaning mechanism 5 cleans the inner wall of the tank body 1 and the surface of the evaluation mechanism 3 to separate the content oil body and the medium water, and an aeration mechanism 6 accelerates the separation speed of the content oil body and the medium water.

[0034] like Figure 3 As shown, the evaluation mechanism 3 also includes a lower sample holder 32, a gasket 33 and a filter membrane 34. The upper sample holder 31 is provided with an external thread 311, and the lower sample holder 32 is provided with a first internal thread 321 and a bottom hole 322. The external thread 311 is connected to the first internal thread 321 by threads, and the bottom hole 322 is provided on the lower sample holder 32 at one end away from the upper sample holder 31. The gasket 33 is in contact with the lower sample holder 32 and the filter membrane 34.

[0035] The diameter of the filter membrane 34 is larger than the diameter of the lower sample rack 32. The gasket 33 and the filter membrane 34 are placed on the bottom hole 322 of the lower sample rack 32. An appropriate amount of soft capsules are placed on the filter membrane 34. The lower sample rack 32 is assembled with the upper sample rack 31 through the threaded connection between the external thread 311 and the first internal thread 321. The fixed axis torque is transmitted through the upper sample rack 31, and the capsule contents are precipitated from the filter membrane 34 under the action of rotation.

[0036] like Figure 4 , Figure 5As shown, the stirring mechanism 4 also includes a first motor 43, a gear rod 44 and a middle rod 45, the middle rod 45 is fixedly connected to the lock pin plate 41, the first motor 43 is fixedly connected to the first side frame 42, the output end of the first motor 43 is fixedly connected to the gear rod 44, the middle rod 45 is provided with a first ring tooth groove 451 and a liquid extraction hole 452, the gear rod 44 is meshed with the tooth surface of the first ring tooth groove 451, the layering mechanism 46 includes a top cylinder 461 and an inner cylinder 464, the middle rod 45 is rotatably connected to the top cylinder 461, and the middle rod 45 is It is slidably connected to the inner cylinder 464, the inner cylinder 464 is provided with a liquid inlet hole 4642, the liquid extraction hole 452 is provided on the end of the middle rod 45 away from the top cylinder 461, and the liquid extraction holes 452 and the liquid inlet holes 4642 are provided in a plurality of groups, and the plurality of groups of liquid extraction holes 452 and liquid inlet holes 4642 are linearly evenly distributed along the axis of the middle rod 45, the liquid extraction holes 452 are in contact with the liquid inlet hole 4642, the top cylinder 461 is provided with a side hole 4612, and the detection mechanism 7 is provided with a liquid extraction pump 71, and the side hole 4612 is connected to the liquid extraction pump 71 through a pipeline.

[0037] The first motor 43 outputs a fixed-axis torque to the gear rod 44, and the gear rod 44 meshes with the tooth surface of the first ring tooth groove 451 provided on the middle rod 45, and the middle rod 45 is rotatably assembled with the top cylinder 461. The gear rod 44 transmits the fixed-axis torque to the middle rod 45, and the middle rod 45 is equipped with a locking pin disk 41 to drive the upper sample rack 31 to rotate on the fixed axis. After the capsule content is precipitated, the liquid extraction pump 71 extracts the mixed liquid into the inner cylinder 464 through the liquid extraction hole 452 and the liquid inlet hole 4642. By a plurality of groups of liquid extraction holes 452 linearly evenly distributed along the axis of the middle rod 45 and located in different liquid layers of the medium water, the mixed liquids of different liquid layers can be directionally extracted for detection and comparative analysis.

[0038] like Figure 4 , Figure 5 As shown, the stratification mechanism 46 also includes a second motor 462 and a threaded rod 463, a top hole 4611 is also provided on the top cylinder 461, the second motor 462 is fixedly connected to the top cylinder 461, the output end of the second motor 462 is fixedly connected to the threaded rod 463, the threaded rod 463 is rotatably connected to the top hole 4611, a second internal thread 4641 and a liquid outlet 4643 are provided on the inner cylinder 464, the second internal thread 4641 is threadedly connected to the threaded rod 463, the inner cylinder 464 is slidably connected to the top cylinder 461, the liquid outlet 4643 is in contact with the side hole 4612, a plurality of groups of liquid outlet holes 4643 are provided, the liquid outlet holes 4643 are provided at one end of the inner cylinder 464 away from the liquid extraction hole 452, and a plurality of groups of liquid outlet holes 4643 are linearly evenly distributed along the axis of the inner cylinder 464.

[0039] The liquid pump 71 pumps the mixed liquid into the inner cylinder 464 through the liquid pumping hole 452 and the liquid inlet hole 4642, and the mixed liquid is pumped out of the inner cylinder 464 through the liquid outlet hole 4643 and the side hole 4612. When adjusting the sampling stratification, the second motor 462 outputs a fixed-axis torque to the threaded rod 463, and the threaded connection between the threaded rod 463 and the second internal thread 4641 on the inner cylinder 464 causes the inner cylinder 464 to move back and forth up and down in the top cylinder 461 and the middle through rod 45. The mixed liquid enters the inner cylinder 464 from the corresponding liquid inlet hole 4642 at the bottom through the liquid pumping holes 452 and the liquid inlet holes 4642 linearly evenly distributed along the axis of the inner cylinder 464, that is, the displacement position of the liquid inlet hole 4642 at the bottom is the liquid layer of the sampled mixed liquid.

[0040] like Figure 6 , Figure 7 As shown, the cleaning mechanism 5 also includes a first gear 53, a second side frame 54, an expansion and contraction mechanism 55 and a servo motor 56. The output end of the third motor 52 is fixedly connected to the first gear 53. The outer concave ring 51 is provided with a second ring tooth groove 511 and a groove 512. The first gear 53 is meshed with the tooth surface of the second ring tooth groove 511. The expansion and contraction mechanism 55 includes a tooth column 553 and a rack 554. The groove 512, the tooth column 553 and the rack 554 are all provided with a plurality of groups. The plurality of groups of grooves 512, the tooth column 553 and the rack 554 are evenly distributed along the circumference of the outer concave ring 51. The second side frame 54 is fixedly connected to the servo motor 56 and the outer concave ring 51. The output end of the servo motor 56 is fixedly connected to a group of tooth columns 553, and the rack 554 is slidably connected to the groove 512.

[0041] When the middle through rod 45 rotates on a fixed axis and the capsule contents are precipitated, the third motor 52 outputs a fixed axis torque to the first gear 53, and the first gear 53 meshes with the tooth surface of the second ring tooth groove 511 on the outer concave ring 51 to transmit the torque to the outer concave ring 51. The outer concave ring 51 rotates around its axis to drive the expansion and contraction mechanism 55 to stir the tank body 1, simulating the movement of the human stomach to make the capsule contents precipitate in accordance with reality. After the dissolution is completed, the outer concave ring 51 continues to rotate to drive the medium to clean the inner wall of the tank body 1 and the surface of the evaluation mechanism 3. Through the principle of centrifugation, the density of the medium water and the content oil body is different. Under the effect of centrifugation, the content oil body is gathered to the center of the vortex, achieving the effect of oil-water separation and self-cleaning.

[0042] like Figure 6 , Figure 7 As shown, the expansion and contraction mechanism 55 also includes an inner concave ring 551 and fan blades 552. The inner concave ring 551 is in contact with the outer concave ring 51. The tooth column 553 is rotatably connected to the inner concave ring 551. The inner concave ring 551 is provided with an inner ring tooth pair 5511. The tooth column 553 is meshed with the rack 554 and the inner ring tooth pair 5511. The fan blades 552 are provided with a plurality of groups. The fan blades 552 are fixedly connected to the rack 554. The plurality of groups of fan blades 552 are evenly distributed along the circumference of the inner concave ring 551.

[0043] When the outer concave ring 51 rotates around its axis, the servo motor 56 outputs a fixed-axis torque to a group of tooth columns 553, and the tooth columns 553 rotate on the inner concave ring 551. The tooth surfaces between the tooth columns 553 and the inner ring tooth pair 5511 on the inner concave ring 551 are meshed, and the inner concave ring 551 rotates in the outer concave ring 51 to transmit the torque to the plurality of groups of tooth columns 553 evenly distributed on the circumference. The tooth surfaces between the tooth columns 553 and the racks 554 are meshed, and the transmitted torque causes the racks 554 to move back and forth in the grooves 512. While the plurality of groups of racks 554 evenly distributed on the circumference drive the fan blades 552 to rotate, the radius of the virtual circle formed is constantly changing, which has the effect of simulating the peristalsis of the stomach bag, so that the precipitation of the capsule contents is in line with reality. At the same time, the medium water is driven to clean itself, and the virtual circle formed by the fan blades 552 is constantly expanding and contracting, so that the stirring vortex force is constantly changing, which can effectively clean the inner wall of the tank body 1 and the surface of the evaluation mechanism 3.

[0044] like Figure 8 As shown, the aeration mechanism 6 is provided with a ring pipe 61 and an aeration tank 62, the aeration tank 62 is fixedly connected to the outer frame 2, aeration holes 12 are provided with a plurality of groups, and the plurality of groups of aeration holes 12 are evenly distributed along the circumference of the tank body 1, and the ring pipe 61 is connected with the aeration holes 12 and the aeration tank 62 through pipelines.

[0045] When the outer concave ring 51 drives the fan blades 552 to rotate for cleaning, the aeration tank 62 aerates the tank body 1 through the ring tube 61 and the aeration holes 12, and introduces a large number of tiny bubbles, so that the hydrophobic oil particles adhere to the bubbles and float to the water surface together with the bubbles, thereby accelerating the separation of oil and water and improving the cleaning effect.

[0046] like Figure 2 As shown, the detection mechanism 7 also includes a detector 72. The liquid pump 71 and the detector 72 are both fixedly connected to the outer frame 2. The liquid pump 71 and the detector 72 are connected via a pipeline.

[0047] The liquid pump 71 pumps the mixed liquid into the inner cylinder 464 through the liquid pumping hole 452 and the liquid inlet hole 4642. The mixed liquid is pumped out of the inner cylinder 464 through the liquid outlet hole 4643 and the side hole 4612 and enters the detector 72 for analysis and detection.

[0048] The working principle of the present invention is as follows: take an appropriate amount of soft capsules and place them on the filter membrane 34, the first motor 43 outputs a fixed-axis torque to the gear rod 44, meshes with the tooth surface between the first ring tooth groove 451, the middle through rod 45 rotates on its own axis, and the capsule content is precipitated from the filter membrane 34 under the action of rotation, and the liquid pump 71 pumps the mixed liquid through the liquid pumping hole 452, the liquid inlet hole 4642, the liquid outlet hole 4643, and the side hole 4612 to enter the detector 72 for analysis and detection. When adjusting the sampling layer, the second motor 462 outputs a fixed-axis torque to the threaded rod 463, Through the threaded connection with the second internal thread 4641, the inner cylinder 464 is moved back and forth up and down in the top cylinder 461 and the middle through rod 45, so that the mixed liquid enters the inner cylinder 464 from the corresponding bottom liquid inlet hole 4642, that is, the displacement position of the bottom liquid inlet hole 4642 is the liquid layer of the sampled mixed liquid, and the third motor 52 outputs a fixed shaft torque to the first gear 53, and the first gear 53 is meshed with the tooth surface of the second ring tooth groove 511 to transmit the torque to the outer concave ring 51, and the servo motor 56 outputs a fixed shaft torque to a group of gear columns 553, through the gear The posts 553 mesh with the tooth surfaces of the inner ring gear pair 5511 on the inner concave ring 551, and the inner concave ring 551 rotates to transmit torque to the plurality of groups of tooth posts 553 evenly distributed on the circumference, and the tooth surfaces of the tooth posts 553 and the racks 554 mesh with each other, and the torque is transmitted to make the racks 554 move back and forth in the groove 512. The plurality of groups of racks 554 evenly distributed on the circumference drive the fan blades 552 to rotate, and the radius of the virtual circle formed is constantly changing, which has the effect of simulating the peristalsis of the stomach bag, so that the precipitation of the capsule contents is in line with reality, and through the principle of centrifugation The densities of the medium water and the content oil body are different. Under the effect of centrifugation, the content oil body is gathered to the center of the vortex, achieving the effect of oil-water separation and self-cleaning. The virtual circle formed by the fan blades 552 is constantly expanding and shrinking, so that the stirring vortex force is constantly changing, which can effectively clean the inner wall of the tank body 1 and the surface of the evaluation mechanism 3. The aeration tank 62 aerates the tank body 1 through the annular tube 61 and the aeration hole 12, and introduces a large number of tiny bubbles, so that the hydrophobic oil body particles are attached to the bubbles and float to the water surface with the bubbles, thereby accelerating the oil-water separation and improving the cleaning effect.

[0049] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. A dissolution detection device for soft capsules with self-cleaning function, characterized in that: The detection device comprises a tank body (1), an outer frame (2), an evaluation mechanism (3), a stirring mechanism (4), a cleaning mechanism (5), an aeration mechanism (6) and a detection mechanism (7); the evaluation mechanism (3) comprises an upper sample rack (31); the stirring mechanism (4) comprises a locking plate (41), a first side frame (42) and a stratification mechanism (46); the upper sample rack (31) is fixedly connected to the locking plate (41); the stratification mechanism (46) is connected to the detection mechanism (7) via a pipeline; The tank body (1) is provided with an upper edge (11) and an aeration hole (12); the cleaning mechanism (5) comprises an outer concave ring (51) and a third motor (52); the outer frame (2) is fixedly connected to the tank body (1), the aeration mechanism (6) and the detection mechanism (7); the aeration hole (12) is fixedly connected to the aeration mechanism (6); the first side frame (42) and the third motor (52) are fixedly connected to the upper edge (11); and the outer concave ring (51) is rotatably connected to the upper edge (11).

2. A dissolution detection device for soft capsules with self-cleaning function according to claim 1, characterized in that: The evaluation mechanism (3) further comprises a lower sample rack (32), a gasket (33) and a filter membrane (34); the upper sample rack (31) is provided with an external thread (311); the lower sample rack (32) is provided with a first internal thread (321) and a bottom hole (322); the external thread (311) and the first internal thread (321) are connected by threads; the bottom hole (322) is provided at one end of the lower sample rack (32) away from the upper sample rack (31); the gasket (33) is in contact with the lower sample rack (32) and the filter membrane (34).

3. The dissolution detection device for soft capsules with self-cleaning function according to claim 1, characterized in that: The stirring mechanism (4) further comprises a first motor (43), a gear rod (44) and a central rod (45); the central rod (45) is fixedly connected to the locking pin plate (41); the first motor (43) is fixedly connected to the first side frame (42); the output end of the first motor (43) is fixedly connected to the gear rod (44); a first annular tooth groove (451) and a liquid extraction hole (452) are provided on the central rod (45); the gear rod (44) and the first annular tooth groove (451) are meshed with each other; the stratification mechanism (46) comprises a top cylinder (461) and an inner cylinder (464); the central rod (45) is rotatably connected to the top cylinder (461); the central rod (45) is rotatably connected to the top cylinder (461); and the central rod (464) is rotatably connected to the top cylinder (461). 5) is slidably connected to the inner cylinder (464), the inner cylinder (464) is provided with a liquid inlet hole (4642), the liquid extraction hole (452) is provided at one end of the middle through rod (45) away from the top cylinder (461), the liquid extraction hole (452) and the liquid inlet hole (4642) are provided in a plurality of groups, and the plurality of groups of the liquid extraction holes (452) and the liquid inlet holes (4642) are linearly evenly distributed along the axis of the middle through rod (45), the liquid extraction holes (452) are in contact with the liquid inlet hole (4642), the top cylinder (461) is provided with a side hole (4612), the detection mechanism (7) is provided with a liquid extraction pump (71), and the side hole (4612) is connected to the liquid extraction pump (71) through a pipeline.

4. A dissolution detection device for soft capsules with self-cleaning function according to claim 3, characterized in that: The stratification mechanism (46) further comprises a second motor (462) and a threaded rod (463); the top cylinder (461) is further provided with a top hole (4611); the second motor (462) is fixedly connected to the top cylinder (461); the output end of the second motor (462) is fixedly connected to the threaded rod (463); the threaded rod (463) is rotatably connected to the top hole (4611); the inner cylinder (464) is provided with a second internal thread (4641) and a liquid outlet hole (4611); 643), the second internal thread (4641) is threadedly connected to the threaded rod (463), the inner cylinder (464) is slidably connected to the top cylinder (461), the liquid outlet hole (4643) is in contact with the side hole (4612), and the liquid outlet holes (4643) are provided in a plurality of groups, and the liquid outlet holes (4643) are provided at one end of the inner cylinder (464) away from the liquid extraction hole (452), and the plurality of groups of liquid outlet holes (4643) are linearly evenly distributed along the axis of the inner cylinder (464).

5. The dissolution detection device for soft capsules with self-cleaning function according to claim 1, characterized in that: The cleaning mechanism (5) further comprises a first gear (53), a second side frame (54), an expansion and contraction mechanism (55) and a servo motor (56); the output end of the third motor (52) is fixedly connected to the first gear (53); a second ring tooth groove (511) and a groove (512) are provided on the outer concave ring (51); the first gear (53) meshes with the tooth surface of the second ring tooth groove (511); the expansion and contraction mechanism (55) comprises a tooth column (553) and a rack (554). The groove (512), the tooth column (553), and the rack (554) are provided in a plurality of groups, and the plurality of groups of the groove (512), the tooth column (553), and the rack (554) are evenly distributed along the circumference of the outer concave ring (51); the second side frame (54) is fixedly connected to the servo motor (56) and the outer concave ring (51); the output end of the servo motor (56) is fixedly connected to a group of tooth columns (553); and the rack (554) is slidably connected to the groove (512).

6. A dissolution detection device for soft capsules with self-cleaning function according to claim 5, characterized in that: The expansion and contraction mechanism (55) also includes an inner concave ring (551) and fan blades (552), wherein the inner concave ring (551) contacts the outer concave ring (51), the tooth column (553) is rotatably connected to the inner concave ring (551), the inner concave ring (551) is provided with an inner ring tooth pair (5511), the tooth column (553) and the rack (554) and the inner ring tooth pair (5511) are all meshed with each other, the fan blades (552) are provided with a plurality of groups, the fan blades (552) are fixedly connected to the rack (554), and the plurality of groups of fan blades (552) are evenly distributed along the circumference of the inner concave ring (551).

7. The dissolution detection device for soft capsules with self-cleaning function according to claim 1, characterized in that: The aeration mechanism (6) is provided with a ring tube (61) and an aeration tank (62); the aeration tank (62) is fixedly connected to the outer frame (2); the aeration holes (12) are provided in a plurality of groups; the plurality of groups of aeration holes (12) are evenly distributed along the circumference of the tank body (1); the ring tube (61) is connected to the aeration holes (12) and the aeration tank (62) through a pipeline.

8. The dissolution detection device for soft capsules with self-cleaning function according to claim 3, characterized in that: The detection mechanism (7) further comprises a detection instrument (72); the liquid extraction pump (71) and the detection instrument (72) are both fixedly connected to the outer frame (2); and the liquid extraction pump (71) and the detection instrument (72) are connected via a pipeline.

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