Automatic sampler of liquid chromatograph and sampling method

Abstract

The invention discloses a liquid chromatograph automatic sampler and a sampling method in the technical field of liquid chromatographs.The liquid chromatograph automatic sampler comprises two base plates, rotating discs are arranged at the tops of the two base plates, a plurality of clamping grooves are formed in the tops of the two rotating discs in a penetrating mode, and guide rails are arranged at one ends of the two base plates; a linear motor is movably connected to the top of the guide rail, a supporting column is arranged at the top of the linear motor, and a rotating end is arranged at the top of the supporting column. The sampling efficiency is improved, the links of manual operation are greatly reduced through automatic sampling, and the sampling efficiency is improved. And the automatic sampler can accurately control the movement and clamping of the test tube, so that the error caused by manual operation is avoided. And the protection pad on the electric clamping jaw can effectively prevent the test tube from being damaged in the clamping process, so that the integrity of the sample is protected.

Description

Technical Field

[0001] The invention relates to the technical field of liquid chromatographs, in particular to an automatic sampler for a liquid chromatograph and a sampling method. Background Art

[0002] Liquid chromatography is an instrument that uses the difference in the distribution ratio of a mixture between liquid and solid or between two immiscible liquids to first separate the mixture and then analyze and identify it.

[0003] In the field of liquid chromatography technology, traditional sampling methods often rely on manual operation, which is not only inefficient but also prone to human errors. During manual sampling, the operator needs to manually place the liquid sample to be tested into a test tube, and then place the test tube into the liquid chromatograph for testing. During this process, the operator needs to move the test tube repeatedly, which is not only labor-intensive, but may also cause sample contamination or loss due to improper operation, thereby affecting the accuracy of the test results. In addition, with the increase in liquid chromatograph detection tasks, manual sampling methods can no longer meet the needs of efficient and accurate detection. Summary of the invention

[0004] The object of the present invention is to provide a liquid chromatograph automatic sampler and a sampling method to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a liquid chromatograph automatic sampler comprises two chassis, the top of each of the two chassis is provided with a rotating disk, the top of each of the two rotating disks is penetrated with a plurality of slots, one end of the two chassis is provided with a guide rail, the top of the guide rail is movably connected with a linear motor, the top of the linear motor is provided with a support column, the top of the support column is provided with a rotating end, a side wall of the rotating end is fixedly connected with a support arm, a lifting electric push rod is provided at the bottom of the end of the support arm away from the rotating end, the output end of the lifting electric push rod is arranged toward the bottom, the output end of the lifting electric push rod is fixedly connected with a bottom plate, the end of the bottom plate away from the lifting electric push rod is fixedly connected with an electric clamp, and the end of the bottom plate close to the electric clamp is fixedly connected with a detection sensor.

[0006] As a further solution of the present invention: an arc-shaped groove is formed at one end of the electric clamping jaws that are close to each other, and a protective pad is fixedly connected to the inner wall of the arc-shaped groove.

[0007] As a further solution of the present invention: the bottom of the support column is detachably connected to the top of the linear motor through a flange, and the top of the lifting electric push rod is detachably connected to the bottom of the support arm through a flange.

[0008] As a further solution of the present invention: the top inner wall of the support column is provided with a top inner cavity, the inner wall of the top inner cavity is fixedly connected with a rotating motor, the output end of the rotating motor is arranged toward the top, and the output end of the rotating motor is fixedly connected to the bottom of the rotating end.

[0009] As a further solution of the present invention: the inner walls of the two chassis are each provided with a bottom working cavity, the inner walls of the two bottom working cavities are fixedly connected with a feeding motor, the output ends of the two feeding motors are both arranged toward the top, and the output ends of the two feeding motors are fixedly connected to the bottom of a rotating disk with matching position.

[0010] As a further solution of the present invention: the height distance between the top and bottom of the two rotating disks is greater than the height distance between the top and bottom of the slots, and the inner walls of the plurality of slots are connected with liquid supply tubes.

[0011] As a further solution of the present invention: the bottom outer walls of the two chassis are fixedly connected with fixed flanges.

[0012] The automatic sampling method of liquid chromatograph comprises the automatic sampler mentioned above and the following steps:

[0013] S100: placing the liquid to be tested into a liquid supply test tube, and inserting the test tube into a corresponding card slot;

[0014] S200: According to the detection result, the feeding motor is started to drive the rotating disk to rotate until the corresponding supply test tube rotates to one end close to the guide rail;

[0015] S300: Control the linear motor to start through the control program, approach one end of the rotating disk, and start the rotating motor to drive the arm to move to the top of the rotating disk;

[0016] S400: The electric clamp is driven to move up and down to the corresponding position by the lifting electric push rod, and the position of the liquid supply test tube is detected by the sensor, and the electric clamp is started to clamp the corresponding liquid supply test tube;

[0017] S500: The sampling operation of the liquid chromatograph is completed by lifting the electric push rod in conjunction with the rotation motor and linear motor. At the same time, the empty liquid supply test tube is clamped to another rotating disk for discharge.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] Improve sampling efficiency. Through automated sampling, the manual operation process is greatly reduced, thus improving sampling efficiency.

[0020] Reduce human errors. The automatic sampler can accurately control the movement and clamping of the test tube, avoiding errors caused by human operation.

[0021] To protect the sample, the protective pad on the electric clamp can effectively prevent the test tube from being damaged during the clamping process, thereby protecting the integrity of the sample.

[0022] It has strong adaptability and can accommodate multiple test tubes through the design of the rotating disk and the card slot, which is suitable for testing different batches of liquid samples.

[0023] Easy to maintain, the components are detachably connected through flanges, etc., which is convenient for daily maintenance and replacement of damaged parts. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the main structure of the automatic sampler and sampling method of the liquid chromatograph of the present invention;

[0025] Figure 2 The invention relates to a liquid chromatograph automatic sampler and a sampling method Figure 1 A schematic diagram of the structure enlargement at the center A;

[0026] Figure 3 It is a schematic diagram of the structure enlargement of the top inner cavity in the automatic sampler and sampling method of the liquid chromatograph of the present invention;

[0027] Figure 4 It is an enlarged schematic diagram of the exploded structure of the chassis in the automatic sampler and sampling method of the liquid chromatograph of the present invention.

[0028] In the figure: 1. chassis; 2. fixing flange; 3. rotating disk; 4. guide rail; 5. linear motor; 6. support column; 7. rotating end; 8. support arm; 9. lifting electric push rod; 10. bottom plate; 11. electric clamp; 12. arc groove; 13. top inner cavity; 14. rotating motor; 15. card slot; 16. liquid supply test tube; 17. bottom working cavity; 18. feeding motor. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] The terms "first", "second", etc. in the specification and claims of the present application are used to distinguish similar objects, and are not used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable under appropriate circumstances, so that the embodiments of the present application can be implemented in an order other than those illustrated or described here, and the objects distinguished by "first", "second", etc. are generally of one type, and the number of objects is not limited. For example, the first object can be one or more. In addition, "and / or" in the specification and claims represents at least one of the connected objects, and the character " / " generally indicates that the objects associated with each other are in an "or" relationship.

[0031] In the description of the present invention, it should be understood that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0032] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "set" should be understood in a broad sense, for example, they can be fixedly connected or set, or detachably connected or set, or integrally connected or set. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0033] Embodiment 1:

[0034] See also Figures 1 to 4 In the embodiment of the present invention, the automatic sampler of liquid chromatograph comprises two chassis 1, the top of the two chassis 1 is provided with a rotating disk 3, the top of the two rotating disks 3 is penetrated with a plurality of slots 15, one end of the two chassis 1 is provided with a guide rail 4, the top of the guide rail 4 is movably connected with a linear motor 5, the top of the linear motor 5 is provided with a support column 6, the top of the support column 6 is provided with a rotating end 7, a side wall of the rotating end 7 is fixedly connected with a support arm 8, a bottom of the support arm 8 away from the rotating end 7 is provided with a lifting electric push rod 9, the output end of the lifting electric push rod 9 is arranged toward the bottom, the output end of the lifting electric push rod 9 is fixedly connected with a bottom plate 10, the end of the bottom plate 10 away from the lifting electric push rod 9 is fixedly connected with an electric clamp 11, and the end of the bottom plate 10 close to the electric clamp 11 is fixedly connected with a detection sensor.

[0035] An arc groove 12 is provided at one end of the electric clamping jaws 11 that are close to each other, and a protective pad is fixedly connected to the inner wall of the arc groove 12. The bottom of the support column 6 is detachably connected to the top of the linear motor 5 through a flange, and the top of the lifting electric push rod 9 is detachably connected to the bottom of the support arm 8 through a flange. A top inner cavity 13 is provided on the inner wall of the top end of the support column 6, and a rotating motor 14 is fixedly connected to the inner wall of the top inner cavity 13, and the output end of the rotating motor 14 is arranged toward the top, and the output end of the rotating motor 14 is fixedly connected to the bottom of the rotating end 7.

[0036] The inner walls of the two chassis 1 are provided with bottom working chambers 17, and the inner walls of the two bottom working chambers 17 are fixedly connected with feeding motors 18, and the output ends of the two feeding motors 18 are arranged toward the top, and the output ends of the two feeding motors 18 are fixedly connected with the bottom of the rotating disk 3 with matching positions. The height distance formed between the top and the bottom of the two rotating disks 3 is greater than the height distance formed between the top and the bottom of the card slots 15, and the inner walls of the plurality of card slots 15 are plugged with liquid supply test tubes 16. The bottom outer walls of the two chassis 1 are fixedly connected with fixing flanges 2.

[0037] An automatic sampling method for a liquid chromatograph, comprising the automatic sampler of claims 1 to 7 and the following steps:

[0038] S100: placing the liquid to be tested into the liquid supply test tube 16, and inserting the test tube into the corresponding card slot 15;

[0039] S200: According to the detection result, the feeding motor 18 is started to drive the rotating disk 3 to rotate slowly until the corresponding supply test tube 16 rotates to one end close to the guide rail 4;

[0040] S300: through the control program, the linear motor 5 is controlled to start, the end closest to the rotating disk 3 approaches, and the rotating motor 14 is started to drive the support arm 8 to move to the top of the rotating disk 3;

[0041] S400: The electric clamping claw 11 is driven to move up and down to a corresponding position by the lifting electric push rod 9, and the position of the liquid supply test tube 15 is detected by the sensor, and the electric clamping claw 11 is started to clamp the corresponding liquid supply test tube 15;

[0042] S500: The lifting electric push rod 9 cooperates with the movement of the rotary motor 14 and the linear motor 5 to complete the sampling operation of the liquid chromatograph. At the same time, the empty liquid supply test tube 16 is clamped to another rotating disk 3 for discharge.

[0043] Embodiment 2:

[0044] See also Figures 1 to 4The present embodiment provides an automatic sampler for a liquid chromatograph, comprising two chassis 1, each of which is provided with a rotating disk 3 on the top, and a plurality of slots 15 are provided on the rotating disk for plugging in a liquid supply tube 16. A guide rail 4 is provided at one end of the chassis, and a linear motor 5 is movably connected to the guide rail. A support column 6 is provided at the top of the linear motor, and a rotating end 7 is mounted on the top of the support column, and a support arm 8 is fixedly connected to a side wall of the rotating end. A lifting electric push rod 9 is provided at the bottom of the support arm away from the rotating end, and the output end of the lifting electric push rod faces the bottom and is fixedly connected to a bottom plate 10. An electric clamp 11 is fixedly connected to the end of the bottom plate away from the lifting electric push rod, and a detection sensor is fixedly connected to the end close to the electric clamp.

[0045] In the specific operation, first, the liquid sample to be tested is placed in the liquid supply test tube, and the test tube is inserted into the corresponding card slot. Then, according to the test result or the preset sampling order, the feeding motor 18 is started to drive the rotating disk to rotate, so that the corresponding liquid supply test tube rotates to one end close to the guide rail. Next, the linear motor is started by the control program to make the support arm close to the rotating disk. At the same time, the rotating motor 14 is started to drive the support arm to move to the top of the rotating disk. Then, the electric clamp is driven to rise and fall to the corresponding position by the lifting electric push rod, and the position of the liquid supply test tube is detected by the sensor. When the sensor detects the test tube, the electric clamp is started to clamp the corresponding liquid supply test tube. Finally, the lifting electric push rod cooperates with the movement of the rotating motor and the linear motor to move the clamped test tube to the sampling position of the liquid chromatograph for sampling operation. At the same time, the empty liquid supply test tube is clamped to another rotating disk for discharge or recovery.

[0046] The working principle of the present invention is as follows: Placing the liquid supply test tube 16 : The operator puts the liquid sample to be tested into the liquid supply test tube 16 , and inserts the test tube into the card slot 15 on the rotating disk 3 .

[0047] The rotating disk 3 rotates: according to the detection result or the preset sampling sequence, the feeding motor 18 is started to drive the rotating disk 3 to rotate, so that the corresponding liquid supply test tube 16 rotates to one end close to the guide rail 4.

[0048] Movement of the robotic arm: The linear motor 5 and the rotary motor 14 are started by the control program, so that the support arm 8 and the electric clamp 11 on the base plate 10 move to the top of the rotating disk 3.

[0049] Test tube gripping: The lifting electric push rod 9 drives the electric gripper 11 to descend to the corresponding position, and detects the position of the liquid supply test tube 16 through the sensor. When the sensor detects the test tube, the electric gripper 11 is started to grip the test tube.

[0050] Sampling and discharge: The lifting electric push rod 9 cooperates with the movement of the rotating motor 14 and the linear motor 5 to move the clamped test tube to the sampling position of the liquid chromatograph for sampling. At the same time, the empty liquid supply test tube 16 is clamped to another rotating disk 3 for discharge or recovery. In the whole process, the coordinated work between the various components realizes the purpose of automatic sampling.

[0051] In summary, the liquid chromatograph automatic sampler and sampling method provided by the present invention have the advantages of simple structure, convenient operation, high sampling efficiency, high accuracy, etc., and are suitable for various liquid chromatograph detection tasks.

[0052] It should be noted that, in this article, the terms "comprise", "include" or any other variant thereof are intended to cover non-exclusive inclusion, so that the process, method, article or device including a series of elements includes not only those elements, but also includes other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise one..." do not exclude the presence of other identical elements in the process, method, article or device including the element. In addition, it should be pointed out that the scope of the methods and devices in the embodiments of the present application is not limited to performing functions in the order shown or discussed, and may also include performing functions in a substantially simultaneous manner or in reverse order according to the functions involved, for example, the described method may be performed in an order different from that described, and various steps may also be added, omitted, or combined. In addition, the features described with reference to certain examples may be combined in other examples.

[0053] The embodiments of the present application are described above in conjunction with the accompanying drawings, but the present application is not limited to the above-mentioned specific implementation methods. The above-mentioned specific implementation methods are merely illustrative and not restrictive. Under the guidance of the present application, ordinary technicians in this field can also make many forms without departing from the purpose of the present application and the scope of protection of the claims, all of which are within the protection of the present application.

Claims

1. A liquid chromatograph automatic sampler, comprising two chassis (1), characterized in that: A rotating disk (3) is provided at the top of the two chassis (1), and a plurality of slots (15) are provided on the top of the two rotating disks (3). A guide rail (4) is provided at one end of the two chassis (1), and a linear motor (5) is movably connected to the top of the guide rail (4). A support column (6) is provided at the top of the linear motor (5). A rotating end (7) is provided at the top of the support column (6). A support arm (8) is fixedly connected to a side wall of the rotating end (7). A lifting electric push rod (9) is provided at the bottom of an end of the support arm (8) away from the rotating end (7). The output end of the lifting electric push rod (9) is arranged toward the bottom. The output end of the lifting electric push rod (9) is fixedly connected to a bottom plate (10). An end of the bottom plate (10) away from the lifting electric push rod (9) is fixedly connected to an electric clamp (11), and an end of the bottom plate (10) close to the electric clamp (11) is fixedly connected to a detection sensor.

2. The liquid chromatograph automatic sampler according to claim 1, characterized in that: An arc-shaped groove (12) is formed at one end of the electric clamping jaws (11) close to each other, and a protective pad is fixedly connected to the inner wall of the arc-shaped groove (12).

3. The liquid chromatograph automatic sampler according to claim 1, characterized in that: The bottom of the support column (6) is detachably connected to the top of the linear motor (5) via a flange, and the top of the lifting electric push rod (9) is detachably connected to the bottom of the support arm (8) via a flange.

4. The liquid chromatograph automatic sampler according to claim 1, characterized in that: The top inner wall of the support column (6) is provided with a top inner cavity (13), the inner wall of the top inner cavity (13) is fixedly connected with a rotating motor (14), the output end of the rotating motor (14) is arranged toward the top, and the output end of the rotating motor (14) is fixedly connected to the bottom of the rotating end head (7).

5. The liquid chromatograph automatic sampler according to claim 1, characterized in that: The inner walls of the two chassis (1) are each provided with a bottom working cavity (17), the inner walls of the two bottom working cavities (17) are each fixedly connected with a feeding motor (18), the output ends of the two feeding motors (18) are each arranged toward the top, and the output ends of the two feeding motors (18) are each fixedly connected to the bottom of a rotating disk (3) of matching position.

6. The liquid chromatograph automatic sampler according to claim 1, characterized in that: The height distance between the top and bottom of the two rotating disks (3) is greater than the height distance between the top and bottom of the card slot (15), and the inner walls of the plurality of card slots (15) are plugged with liquid supply test tubes (16).

7. The liquid chromatograph automatic sampler according to claim 1, characterized in that: The bottom outer walls of the two chassis (1) are both fixedly connected with a fixing flange (2).

8. A liquid chromatograph automatic sampling method, characterized in that: The method comprises the automatic sampler according to claim 1 to claim 7 and the following steps: S100: placing the liquid to be tested into a liquid supply test tube (16), and inserting the test tube into a corresponding card slot (15); S200: According to the detection result, the feeding motor (18) is started to drive the rotating disk (3) to rotate until the corresponding supply test tube (16) rotates to one end close to the guide rail (4); S300: Control the linear motor (5) to start through the control program, and move the end closest to the rotating disk (3) closer, and start the rotating motor (14) to drive the support arm (8) to move to the top of the rotating disk (3); S400: The electric clamp (11) is driven to rise and fall to a corresponding position by the lifting electric push rod (9), and the position of the liquid supply test tube (15) is detected by the sensor, and the corresponding liquid supply test tube (15) is clamped by the electric clamp (11); S500: The lifting electric push rod (9) cooperates with the movement of the rotating motor (14) and the linear motor (5) to complete the sampling operation of the liquid chromatograph. At the same time, the empty liquid supply test tube (16) is clamped onto another rotating disk (3) for discharge.

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