Tissue cutting needle, tumor cell puncture sampling device and sampling method

Abstract

The invention belongs to the technical field of biopsy needles, and particularly discloses a tissue cutting needle, a tumor cell puncture sampling device and a sampling method.The tissue cutting needle comprises a needle core and an outer sleeve arranged on the outer side of the needle core in a sleeving mode, a sampling groove is formed in the needle core, the needle core comprises a needle body and a cutting blade, and the needle body is provided with a sliding block; the needle body is sleeved with the outer sleeve, a first inclined groove is formed in the end, close to the sampling groove, of the outer sleeve, a path groove is formed in the outer sleeve and comprises a transverse groove and an annular groove, and when the sliding block slides along the transverse groove, the first inclined groove is matched with the sampling groove to be used for conducting primary cutting on tissue, and when the sliding block slides along the annular groove, the second inclined groove is matched with the annular groove to be used for conducting secondary cutting on tissue. And the cutting blade is used for carrying out secondary cutting on tissues. By means of the collaborative movement design of the needle core and the outer sleeve, the compound function of two times of cutting is achieved, the phenomenon of needle vacancy is avoided, and the cutting efficiency is effectively improved.

Description

Technical Field

[0001] The invention belongs to the technical field of biopsy needles, and in particular relates to a tissue cutting needle, a tumor cell puncture sampling device and a sampling method. Background Art

[0002] A biopsy needle is a medical device that is suitable for a variety of organs such as the kidney, liver, lung, breast, thyroid, prostate, pancreas, testicle, uterus, ovary, and body surface. It can be used for sampling and aspirating cells from living tissues of pyramidal tumors and tumors of unknown types. Biopsy needles can be divided into cell aspiration needles, tissue cutting needles, and trephine needles. Among them, the cell aspiration needle is a thin metal needle with a syringe at the tail end. It is inserted into the tissue under negative pressure to obtain tissue debris and cell clusters for cytopathological examination. The tissue cutting needle uses cutting force to cut local tissue into the needle groove for histopathological examination. The trephine needle, also known as the bone marrow biopsy needle, is used for bone tissue biopsy. It uses a sharp trephine with a needle core. After the tip of the needle core penetrates the bone cortex, the needle handle is repeatedly rotated and generates an external force to push forward. The trephine is used to continuously cut the cancellous bone and fill the bone tissue into the needle channel to remove it.

[0003] At present, the most commonly used biopsy needle for puncture biopsy is the side groove / groove cutting biopsy needle in the tissue cutting needle. Specifically, the doctor slowly inserts the biopsy needle into the tissue according to the predetermined puncture path, and under the guidance of the imaging equipment, pushes the biopsy needle to the edge of the lesion. When the biopsy needle reaches the edge of the lesion, the needle core is pushed forward so that the sampling groove partially enters the diseased tissue to obtain a tissue sample. At this time, the diseased tissue will enter the sampling groove, and then the outer cannula is quickly pushed forward to cut and close the sampling groove, cutting off the tissue sample entering the sampling groove and retaining it in the groove. Finally, the biopsy needle is pulled out as a whole, and the tissue sample is taken out from the sampling groove. The sampling groove is the side groove / groove.

[0004] When doctors use side groove / groove cutting biopsy needles, they find that there is often an empty needle after the biopsy needle is pulled out. In vitro experimental studies have found that when using a side groove / groove cutting biopsy needle for puncture, after the diseased tissue enters the sampling groove, the outer cannula will not be able to completely close the sampling groove during the advancement of the outer cannula. This causes the cutting during the advancement of the outer cannula to not cut off the tissue sample entering the sampling groove, which in turn causes the tissue sample in the sampling groove to remain completely separated from the diseased tissue. When the biopsy needle is pulled out as a whole, the tissue sample in the sampling groove is pulled by the diseased tissue and falls off from the sampling groove. When the biopsy needle is pulled out as a whole, an empty needle will appear. Summary of the invention

[0005] In view of the above-mentioned problems, the purpose of the present invention is to provide a tissue cutting needle, a tumor cell puncture sampling device and a sampling method, which effectively avoid the empty needle phenomenon when sampling tumor cells.

[0006] The technical solution of the present invention is: a tissue cutting needle, comprising a needle core and an outer sleeve sleeved on the outer side of the needle core, and a sampling groove is arranged on the needle core.

[0007] The needle core includes a needle body and a cutting blade. The needle body is provided with a slider, and the sampling groove is provided on the needle body, and the groove length of the sampling groove is parallel to the axis of the needle body. The cutting blade is arranged in the sampling groove along the groove length direction of the sampling groove, and is in the same arc surface as the outer side surface of the needle body, and the cutting blade and the needle body are an integrated structure.

[0008] The outer sleeve is sleeved on the outer side of the needle body, and a first inclined groove is provided at one end of the outer sleeve close to the sampling groove, and a path groove is provided inside the outer sleeve, and the path groove includes a transverse groove and an annular groove. The transverse groove is provided on the inner wall of the outer sleeve and is parallel to the axis of the outer sleeve. The annular groove is provided on the inner wall of the outer sleeve and is perpendicular to the axis of the outer sleeve, and one end of the annular groove away from the first inclined groove is connected to the transverse groove; the slider is slidably provided in the path groove, and when the slider slides along the transverse groove, the first inclined groove cooperates with the sampling groove to perform a primary cutting of the tissue, and when the slider slides along the annular groove, the cutting blade is used to perform a secondary cutting of the tissue.

[0009] The combined function of two cuts is achieved through the coordinated motion design of the needle core and the outer cannula. When the slider slides along the transverse groove, the first oblique groove of the outer cannula and the needle core sampling groove form a shear force to complete the first tissue cutting; and after the slider enters the annular groove, as the needle body rotates, the one-piece cutting blade performs a second cut on the tissue. Compared with traditional single-cutting instruments, this two-stage cutting mechanism effectively reduces the risk of tissue tearing. Even if the outer cannula cannot completely cover the sampling groove, the cutting blade will be used to perform a second cut on the tissue, avoiding the phenomenon of an empty needle and effectively improving the cutting efficiency. .

[0010] By using the way of cooperating between the path groove and the slider, the first oblique groove of the outer cannula port first cuts the tissue in the sampling groove along the needle body and needle axis, and then after the slider slides to the annular groove, the needle body can use its own rotation to drive the cutting blade to cut axially along the needle body and needle axis. The sliding of the slider in the path groove provides trajectory control for the relative movement of the needle body and the outer cannula.

[0011] Furthermore, a puncture bevel groove is provided at the end of one end of the needle body, and the puncture bevel groove cuts the end of the sampling section into a needle tip shape, and the sampling groove is located at the end of the needle body close to the puncture bevel groove. This design makes the end of the needle body sharper, which can penetrate the tissue more easily, reduce the resistance during the puncture process, and thus improve the puncture efficiency. The sampling groove is located at one end close to the puncture bevel groove. This layout enables tissue sampling to be quickly performed through the sampling groove after the puncture is successful, reducing the possibility of tissue displacement or damage and improving the accuracy of sampling.

[0012] Furthermore, the longitudinal section of the sampling groove along the axis of the needle body is an inverted trapezoidal structure. The sampling groove of the inverted trapezoidal structure can collect tissue samples more effectively. Its shape helps to guide the tissue into the sampling groove during the cutting process, reduce tissue damage and loss, and effectively reduce tissue damage during the sampling process. Its smooth edges and gradually widening shape help to reduce cutting and squeezing of tissues, reducing the risk of tissue damage.

[0013] Furthermore, the needle body is provided with a second bevel, which is located on the side of the sampling slot near the puncture bevel. The outer sleeve is provided with an arc piece, which is distributed along the outer edge of the upper half of the first bevel, and when a cut is made, the arc piece hits the second bevel. The arc piece hits the second bevel to form a shear force, which can effectively cut the tissue in the sampling slot, avoiding the problem of continuous cutting of the tissue from the gap between the outer sleeve and the needle body. In addition, the arc piece cannot continue to cut after hitting the second bevel, and the cutting depth can be accurately controlled, thereby avoiding excessive cutting and reducing damage to surrounding tissues.

[0014] Furthermore, the second inclined groove and the side of the sampling groove form an angled groove, the longitudinal section of the folded groove along the axis of the needle body is a folded line, and the inclination angle of the second inclined groove is smaller than the inclination angle of the side of the sampling groove. The design of the angled groove helps to improve the cutting efficiency. In one cutting action, the tissue can enter the sampling groove more smoothly, and the arc piece hits the bevel of the second inclined groove. When the inclination angle is small, the arc piece has a small buffer displacement after hitting the second inclined groove, avoiding the problem that the arc piece is easy to break due to the excessive inclination angle of the second inclined groove.

[0015] Furthermore, the effective height of the arc piece is less than the effective height of the second inclined groove. This can make the tissue more fixed in the sampling groove. During the cutting process, the tissue is more easily confined in the sampling groove, reducing the possibility of tissue movement, thereby improving the accuracy and reliability of sampling. In addition, the damage to the tissue during the sampling process is reduced. During cutting, the cutting force on the tissue is more uniform, reducing the squeezing and tearing of the tissue, and reducing the risk of tissue damage.

[0016] Furthermore, there are two cutting blades, which are relatively distributed on the outer edge of the sampling slot, and the cutting blades and the needle body are an integrated structure. The two cutting blades are bidirectionally distributed, so there is no requirement for the rotation direction of the needle body during secondary cutting, and its adaptability is stronger.

[0017] Furthermore, a chamfered cut is provided at the connection between the transverse groove and the annular groove. Since there is a certain error in the relative displacement between the outer sleeve and the needle body, in order to avoid the error in relative displacement causing the slider to be unable to enter the annular groove from the transverse groove, a chamfered cut is provided at the connection between the transverse groove and the annular groove, so that the process of the slider entering the annular groove from the transverse groove has a certain transition that can offset the error in relative displacement.

[0018] A tumor cell puncture sampling device comprises a handle, in which a first firing assembly and a second firing assembly are arranged, the tissue cutting needle is inserted into the handle, the first firing assembly is connected to the needle body, and the first firing assembly utilizes its own deformation to move the needle body along the axis of the needle body to realize the energy storage and firing process of the needle body; the second firing assembly is connected to the outer sleeve, and the second firing assembly utilizes its own deformation to move the outer sleeve along the axis of the outer sleeve to realize the energy storage and firing process of the outer sleeve.

[0019] A driving assembly is also provided in the handle, and the driving assembly is connected to the needle body and is used to drive the needle body to rotate after the needle body is fired.

[0020] A method for puncturing and sampling tumor cells, using the tumor cell puncturing and sampling device described in the claims for sampling, specifically comprising the following steps: The first firing assembly is used to store energy in the needle body, and the second firing assembly is used to store energy in the outer sleeve.

[0021] The needle body is fired by the first firing assembly, and the outer sleeve is fired by the second firing assembly. The slider slides along the transverse groove, and the first inclined groove cooperates with the sampling groove to perform a primary cut. The driving assembly drives the needle body to rotate, and when the slider slides along the annular groove, the cutting blade performs a secondary cut.

[0022] The second firing assembly is used to store energy in the outer sleeve, so that one end of the needle body with the sampling groove is exposed from the outer sleeve.

[0023] Compared with the prior art, the beneficial effect of the present invention is that the present invention realizes the compound function of two cuts through the coordinated movement design of the needle core and the outer sleeve. When the slider slides along the transverse groove, the first oblique groove of the outer sleeve and the needle core sampling groove form a shear force to complete the first tissue cutting; and after the slider enters the annular groove, as the needle body rotates, the one-piece cutting blade performs a second cut on the tissue. Compared with traditional single-cutting instruments, this two-stage cutting mechanism effectively reduces the risk of tissue tearing. Even if the outer sleeve cannot completely cover the sampling groove, the cutting blade will be used to perform a second cut on the tissue, avoiding the phenomenon of empty needles and effectively improving the cutting efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1This is a structural cross-sectional view of a tissue cutting needle according to Example 1 of the present invention; Figure 2 It is a partial structural schematic diagram of the tissue cutting needle of Example 1 of the present invention; Figure 3 is a partial cross-sectional view of the tissue cutting needle of Example 1 of the present invention; Figure 4 yes Figure 3 A magnified view of point A; Figure 5 It is a partial structural schematic diagram of the outer sleeve of the present invention; Figure 6 is a schematic diagram of the partial structure of the tissue cutting needle of Example 2 of the present invention; Figure 7 This is a schematic diagram of the external structure of the tumor cell puncture sampling device of Example 3 of the present invention; Figure 8 This is a schematic diagram of the internal structure of the tumor cell puncture sampling device of Example 3 of the present invention; Fig. 9 is a schematic diagram of a partial structure of a drive assembly according to Embodiment 3 of the present invention; Fig.10 This is a sampling flow chart of the tumor cell puncture sampling device of Example 3 of the present invention.

[0025] Among them, 1-needle core, 10-sampling slot, 11-needle body, 111-slider, 112-puncture bevel slot, 113-second bevel slot, 12-cutting blade, 2-outer sleeve, 200-first bevel slot, 20-path slot, 201-transverse slot, 202-annular slot, 203-chamfered incision, 21-arc piece, 3-handle, 31-first firing assembly, 32-second firing assembly, 4-drive assembly, 41-disc shell, 42-spring, 43-mounting column, 44-block, 45-gear box, 46-push knob. DETAILED DESCRIPTION

[0026] The following is combined with Figure 1 To the attached Fig.10 , the specific embodiments of the present invention are described in detail. In the description of the present invention, it should be understood that the terms "center", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention.

[0027] The terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features; in the description of the present invention, unless otherwise specified, "plurality" means two or more.

[0028] Example 1 like Figure 1 The tissue cutting needle shown comprises a needle core 1 and an outer sleeve 2 sleeved on the outer side of the needle core 1 , and a sampling groove 10 is arranged on the needle core 1 .

[0029] like Figure 1 , Figure 2 , Figure 3 As shown, the needle core 1 includes a needle body 11 and a cutting blade 12. The needle body 11 is provided with a slider 111, and the sampling slot 10 is arranged on the needle body 11, and the slot length of the sampling slot 10 is parallel to the axis of the needle body 11. The cutting blade 12 is arranged in the sampling slot 10 along the slot length direction of the sampling slot 10, and is in the same arc surface as the outer side surface of the needle body 11, and the cutting blade 12 and the needle body 11 are an integral structure. Among them, the design of the integrated cutting blade 12 reduces the complexity of assembly and reduces the risk of the blade falling off, while ensuring a smooth transition between the cutting blade and the surface of the needle body to avoid additional damage to the surrounding tissue. In addition, the design of the cutting blade 12 and the outer side surface of the needle body 11 sharing the same arc surface reduces the risk of tissue tearing during cutting, making the cutting process closer to natural tissue separation.

[0030] like Figure 1 As shown, the outer sleeve 2 is sleeved on the outer side of the needle body 11, and a first inclined groove 200 is provided at one end of the outer sleeve 2 close to the sampling groove 10, and a path groove 20 is provided inside the outer sleeve 2, and the path groove 20 includes a transverse groove 201 and an annular groove 202. The transverse groove 201 is provided on the inner wall of the outer sleeve 2, parallel to the axis of the outer sleeve 2. The annular groove 202 is provided on the inner wall of the outer sleeve 2, perpendicular to the axis of the outer sleeve 2, and the end of the annular groove 202 away from the first inclined groove 200 is connected to the transverse groove 201; the slider 111 is slidably provided in the path groove 20, and when the slider 111 slides along the transverse groove 201, the first inclined groove 200 cooperates with the sampling groove 10 to cut the tissue once, and when the slider 111 slides along the annular groove 202, the cutting blade 12 is used to cut the tissue twice.

[0031] Since there is a phenomenon of empty needle when the traditional side groove / groove cuts the biopsy needle. Therefore, this embodiment realizes the composite function of two cuttings through the coordinated movement design of the needle core 1 and the outer sleeve 2. When the slider 111 slides along the transverse groove 201, the first inclined groove 200 of the outer sleeve and the needle core sampling groove 10 form a shear force to complete the first tissue cutting; and after the slider 111 enters the annular groove 202, as the needle body 11 rotates, the one-piece cutting blade 12 performs a second cutting on the tissue. Compared with traditional single-time cutting instruments, this two-stage cutting mechanism effectively reduces the risk of tissue tearing. Even if the outer sleeve 2 cannot completely cover the sampling groove 10, the cutting blade 12 can be used to cut the tissue, avoiding the phenomenon of empty needle and effectively improving the cutting efficiency.

[0032] In addition, the two cuts effectively improve the integrity of tissue samples and avoid problems such as insufficient sample volume or tissue residue caused by insufficient single cutting.

[0033] Through the design of the path groove 20, the motion trajectory of the slider 111 is strictly limited. When in use, the first inclined groove 200 at the port of the outer sleeve 2 first cuts the tissue in the sampling groove 10 along the needle axis of the needle body 11, and then the needle body 11 can use its rotation to drive the cutting blade 12 to cut axially along the needle axis of the needle body 11 after the slider 111 slides to the annular groove 202. The sliding of the slider 111 in the path groove 20 provides trajectory control for the relative movement of the needle body 11 and the outer sleeve 2.

[0034] Preferably, Figure 4 As shown, a puncture bevel 112 is provided at the end of one end of the needle body 11, and the puncture bevel 112 cuts the end of the sampling section 11 into a needle tip shape, and the sampling slot 10 is located at one end of the needle body 11 close to the puncture bevel 112. This design makes the end of the needle body 11 sharper and can penetrate the tissue more easily, reducing the resistance during the puncture process, thereby improving the puncture efficiency. The sampling slot 10 is located at one end close to the puncture bevel 112. Such a layout enables tissue sampling to be quickly performed through the sampling slot 10 after the puncture is successful, reducing the possibility of tissue displacement or damage and improving the accuracy of sampling. When using a tissue cutting needle, the position of puncture and sampling can be determined more intuitively, the operation is simpler, and the difficulty of operation is reduced.

[0035] Preferably, Figure 1 , Figure 2 , Figure 3As shown, the longitudinal section of the sampling slot 10 along the axis of the needle body 11 is an inverted trapezoidal structure. The sampling slot 10 with an inverted trapezoidal structure can collect tissue samples more effectively. Its shape helps to guide the tissue into the sampling slot during the cutting process, reduce tissue damage and loss, and effectively reduce tissue damage during the sampling process. Its smooth edges and gradually widening shape help to reduce cutting and squeezing of the tissue, reducing the risk of tissue damage. In addition, the sampling slot 10 with an inverted trapezoidal structure makes it easier for the operator to control the insertion and removal process of the tissue cutting needle. Its unique shape provides better visual and tactile feedback, making the operation more precise and safe. It is also easier for the tissue to fall off and separate from the sampling slot 10 after the tissue cutting needle is withdrawn at a later stage.

[0036] Preferably, Figure 4 As shown, the needle body 11 is provided with a second bevel groove 113, and the second bevel groove 113 is located on the side of the sampling slot 10 near the puncture bevel groove 112; the outer sleeve 2 is provided with an arc piece 21, and the arc piece 21 is distributed along the outer edge of the upper half of the first bevel groove 200. When a cutting is performed, the arc piece 21 hits the second bevel groove 113. The arc piece 21 hits the second bevel groove 113 to form a shear force, which can effectively cut the tissue in the sampling slot 10, avoiding the problem of continuous cutting of the tissue from the gap between the outer sleeve 2 and the needle body 11. In addition, the arc piece 21 cannot continue to cut after hitting the second bevel groove 113, and the cutting depth can be accurately controlled, thereby avoiding excessive cutting and reducing damage to surrounding tissues. Most importantly, the arc piece 21 hitting the second bevel groove 113 can also effectively increase the success rate of a single cutting and avoid the empty needle phenomenon.

[0037] The arc piece 21 is an integral structure with the outer sleeve 2, and it has certain deformation properties. In actual use, the arc piece 21 is inclined toward the axis of the outer sleeve 2. When the arc piece 21 is in the needle segment position of the needle body 11 where the sampling slot 10 is arranged, the arc piece 21 is inclined toward the sampling slot 10, so that the tissue can be effectively cut when it hits the second inclined slot 113 later. When the arc piece 21 is in the remaining needle segment positions of the needle body 11, the arc piece 21 relies on its own deformation to be in close contact with the outer wall of the needle body 11. It should be noted that the width of the arc piece 21 is relatively narrow, and it will not scrape against the needle body 11 to cause large friction, and has little effect on the firing process.

[0038] Preferably, Figure 4As shown, the second inclined groove 113 and the side of the sampling groove 10 form an angled groove, the longitudinal section of the folded groove along the axis of the needle body 11 is a folded line, and the inclination angle of the second inclined groove 113 is smaller than the inclination angle of the side of the sampling groove 10. The design of the angled groove helps to improve the cutting efficiency. In one cutting action, the tissue can enter the sampling groove more smoothly, and the arc piece 21 hits the bevel of the second inclined groove 113. When the inclination angle is small, the arc piece 21 has a small buffer displacement after hitting the second inclined groove 113, avoiding the problem that the arc piece 21 is easy to break due to the excessive inclination angle of the second inclined groove 113.

[0039] Preferably, the effective height of the arc piece 21 is less than the effective height of the second inclined groove 113. This can make the tissue more fixed in the sampling groove 10. During the cutting process, the tissue is more easily confined in the sampling groove 10, reducing the possibility of tissue movement, thereby improving the accuracy and reliability of sampling. In addition, the damage to the tissue during the sampling process is reduced. During cutting, the cutting force on the tissue is more uniform, reducing the squeezing and tearing of the tissue, and reducing the risk of tissue damage.

[0040] Preferably, Figure 5 As shown, a chamfered cut 203 is provided at the connection between the transverse groove 201 and the annular groove 202. Since there is a certain error in the relative displacement between the outer sleeve 2 and the needle body 11, in order to avoid the error in relative displacement causing the slider 111 to be unable to enter the annular groove 202 from the transverse groove 201, a chamfered cut 203 is provided at the connection between the transverse groove 201 and the annular groove 202, so that the process of the slider 111 entering the annular groove 202 from the transverse groove 201 has a certain transition that can offset the error in relative displacement. It should be noted that if the error in relative displacement causes the slider 111 to be unable to enter the annular groove 202 from the transverse groove 201, it is impossible to effectively perform a second cut after the first cut.

[0041] Example 2 The difference from Example 1 is that: preferably, Figure 6 As shown, there are two cutting blades 12, and the two cutting blades 12 are relatively distributed on the outer edge of the sampling slot 10. The two-way distribution of the two cutting blades 12 does not require the rotation direction of the needle body 11 during secondary cutting, and its adaptability is stronger.

[0042] Example 3 like Figure 7 , Figure 8A tumor cell puncture sampling device shown in the figure has a handle 3, in which a first firing assembly 31 and a second firing assembly 32 are arranged. The tissue cutting needle proposed in Example 1 is inserted into the handle 3, and the first firing assembly 31 is connected to the needle body 11. The first firing assembly 31 uses its own deformation to move the needle body 11 along the axis of the needle body 11 to realize the energy storage and firing process of the needle body 11; the second firing assembly 32 is connected to the outer sleeve 2, and the second firing assembly 32 uses its own deformation to move the outer sleeve 2 along the axis of the outer sleeve 2 to realize the energy storage and firing process of the outer sleeve 2.

[0043] like Figure 8 As shown, a driving assembly 4 is also provided in the handle 3, and the driving assembly 4 is connected to the needle body 11, and is used to drive the needle body 11 to rotate after the needle body 11 is fired. Figure 8 , Fig. 9 As shown, the drive assembly 4 includes a disk shell 41, a spring 42, a mounting column 43, a clamping block 44, a gear box 45 and a push-type knob 46. The disk shell 41 is arranged in the handle 3. The spring 42 is placed inside the disk shell 41, and its outer end is fixed on the disk shell 41. The mounting column 43 is rotatably arranged on the disk shell 41, passing through the disk shell 41, and the outer wall of the mounting column 43 is connected to the inner end of the spring 42; the mounting column 43 is provided with a through groove, and the through groove is provided with a limiting groove; the needle body 11 is slidably arranged on the mounting column 43, and the needle body 11 is provided with a tooth bar 13, and the tooth bar 13 is slidably arranged in the limiting groove. The clamping block 44 is clamped with the end of the needle body 11 away from the sampling slot 10, and falls off from the clamping block 44 after the needle body 11 is fired. The output end of the gear box 45 is connected to the block 44 and rotates coaxially; the push knob 46 is connected to the input end of the gear box 45. After the push knob 46 is pressed, it rotates coaxially with the input end of the gear box 45. A locking structure is provided on the push knob 46, and it cannot rotate when not pressed.

[0044] It should be noted that the first firing assembly 31 and the second firing assembly 32 proposed in this embodiment are based on the same principle as the firing device of a traditional fully automatic puncture needle, and the handle 3 of this embodiment is also provided with a pressing key, a firing key, etc., and the handle 3 is also provided with limiting parts for the first firing assembly 31 and the second firing assembly 32, which are all conventional technical means in the field and will not be elaborated here.

[0045] A tumor cell puncture sampling method, using the tumor cell puncture sampling device proposed in this embodiment to perform sampling, specifically comprises the following steps: Before puncture, the first firing assembly 31 is used to store energy in the needle body 11, and the second firing assembly 32 is used to store energy in the outer sleeve 2. That is, the pressing key is pressed down, the needle body 11 squeezes the spring of the first firing assembly 31, and the outer sleeve 2 squeezes the spring of the second firing assembly 32. At this time, the needle body 11 moves toward the inside of the handle 3, and its end away from the sampling slot 10 is clamped on the clamping block 44, pressing the push-type knob 46 to rotate, and the clamping block 44 is driven to rotate through the gear box 45, and the needle body 11 rotates with the clamping block 44, driving the mounting column 43 to rotate, and tightening the clockwork 42.

[0046] Puncture: The tip of the needle body 11 and the tip of the outer sleeve 2 are inserted into the tissue and located on one side of the tumor tissue.

[0047] like Fig.10 As shown, after puncture, the needle body 11 is fired by the first firing assembly 31, and the outer cannula 2 is fired by the second firing assembly 32, and the needle body 11 and the outer cannula 2 move into the tissue in sequence. The slider 111 slides along the transverse groove 201, and the first inclined groove 200 cooperates with the sampling groove 10 to cut the tissue once. During this process, the slider 111 is limited by the transverse groove 201, and the needle body 11 cannot rotate. It should be noted that after firing, the needle body 11 and the outer cannula 2 are not ejected synchronously, but the needle body 11 comes out first, and the outer cannula 2 comes out later, and there is a certain time difference between the two, that is, after the needle body 11 pops out and the tissue fills the sampling groove 10, the outer cannula 2 pops out again to cut the tissue.

[0048] When the outer sleeve 2 moves to complete one cutting, the slider 111 passes through the connection between the transverse groove 201 and the annular groove 202 and enters the annular groove 202. The block 44 rotates under the action of the spring 42, and drives the needle body 11 to rotate, and the cutting blade 12 performs a second cutting.

[0049] After the needle is withdrawn, the second firing assembly 32 is used to store energy in the outer sleeve 2 to expose the end of the needle body 11 with the sampling groove 10 from the outer sleeve 2 to remove the tumor cell tissue from the sampling groove 10 .

[0050] The specific embodiments described above further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific embodiment of the present invention and does not limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention are included in the protection scope of the present invention.

Claims

1. A tissue cutting needle, comprising a needle core (1) and an outer sleeve (2) sleeved on the outer side of the needle core (1), wherein a sampling groove (10) is provided on the needle core (1), characterized in that: The needle core (1) comprises: The needle body (11) is provided with a slider (111); the sampling groove (10) is arranged on the needle body (11), and the groove length of the sampling groove (10) is parallel to the axis of the needle body (11); A cutting blade (12) is arranged in the sampling groove (10) along the groove length direction of the sampling groove (10) and is in the same arc surface as the outer side surface of the needle body (11); The outer sleeve (2) is sleeved on the outer side of the needle body (11), and a first inclined groove (200) is provided at one end of the outer sleeve (2) close to the sampling groove (10). A path groove (20) is provided inside the outer sleeve (2), and the path groove (20) comprises: A transverse groove (201) is provided on the inner wall of the outer sleeve (2) and is parallel to the axis of the outer sleeve (2); The annular groove (202) is arranged on the inner wall of the outer sleeve (2) and is perpendicular to the axis of the outer sleeve (2); one end of the annular groove (202) away from the first inclined groove (200) is connected to the transverse groove (201); the slider (111) is slidably arranged in the path groove (20); when the slider (111) slides along the transverse groove (201), the first inclined groove (200) cooperates with the sampling groove (10) to perform a primary cutting of the tissue; when the slider (111) slides along the annular groove (202), the cutting blade (12) is used to perform a secondary cutting of the tissue.

2. A tissue cutting needle as claimed in claim 1, characterized in that: The end of one end of the needle body (11) is provided with a puncture oblique groove (112), the puncture oblique groove (112) cuts the end of the sampling section (11) into a needle tip shape, and the sampling groove (10) is located at one end of the needle body (11) close to the puncture oblique groove (112).

3. A tissue cutting needle as claimed in claim 2, characterized in that: The longitudinal section of the sampling slot (10) along the axis of the needle body (11) is an inverted trapezoidal structure.

4. A tissue cutting needle as claimed in claim 3, characterized in that: The needle body (11) is provided with a second oblique groove (113), and the second oblique groove (113) is located on the side of the sampling groove (10) close to the puncture oblique groove (112); The outer sleeve (2) is provided with an arc piece (21), which is distributed along the outer edge of the upper half of the first inclined groove (200). During a cutting operation, the arc piece (21) hits the second inclined groove (113).

5. A tissue cutting needle as claimed in claim 4, characterized in that: The second inclined groove (113) and the side of the sampling groove (10) form an angled groove, the longitudinal section of the folded groove along the axis of the needle body (11) is a folded line, and the inclination angle of the second inclined groove (113) is smaller than the inclination angle of the side of the sampling groove (10).

6. A tissue cutting needle as claimed in claim 4, characterized in that: The effective height of the arc piece (21) is smaller than the effective height of the second inclined groove (113).

7. The tissue cutting needle according to claim 1, characterized in that: There are two cutting blades (12), which are relatively distributed on the outer edge of the sampling slot (10), and the cutting blades (12) and the needle body (11) are an integral structure.

8. A tissue cutting needle as claimed in claim 1, characterized in that: A chamfered cutout (203) is provided at the connection point between the transverse groove (201) and the annular groove (202).

9. A tumor cell puncture sampling device, comprising a handle (3), wherein a first firing assembly (31) and a second firing assembly (32) are arranged in the handle (3), characterized in that: The tissue cutting needle of claim 1 is inserted into the handle (3), the first firing assembly (31) is connected to the needle body (11), and the first firing assembly (31) uses its own deformation to move the needle body (11) along the axis of the needle body (11) to realize the energy storage and firing process of the needle body (11); the second firing assembly (32) is connected to the outer sleeve (2), and the second firing assembly (32) uses its own deformation to move the outer sleeve (2) along the axis of the outer sleeve (2) to realize the energy storage and firing process of the outer sleeve (2); A driving assembly (4) is also provided in the handle (3); the driving assembly (4) is connected to the needle body (11) and is used to drive the needle body (11) to rotate after the needle body (11) is fired.

10. A method for puncturing and sampling tumor cells, characterized in that: Sampling using the tumor cell puncture sampling device according to claim 9 specifically comprises the following steps: The needle body (11) is stored with the first firing assembly (31), and the outer sleeve (2) is stored with the second firing assembly (32); The needle body (11) is fired by the first firing assembly (31), the outer sleeve (2) is fired by the second firing assembly (32), the slider (111) slides along the transverse groove (201), and the first inclined groove (200) cooperates with the sampling groove (10) to perform a primary cutting; the driving assembly (4) drives the needle body (11) to rotate, and when the slider (111) slides along the annular groove (202), the cutting blade (12) performs a secondary cutting; By utilizing the energy storage of the outer sleeve (2) by the second firing assembly (32), one end of the needle body (11) having the sampling groove (10) is exposed from the outer sleeve (2).

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