Detachable needle module for microdissection

Abstract

The utility model discloses a detachable needle module for microdissection, which belongs to the technical field of microdissection and comprises a driving shaft and a cutting needle. The driving shaft is connected with a quick connection assembly for quick disassembly and quick assembly; the quick connection assembly is connected with a connecting shaft; the end, away from the driving shaft, of the connecting shaft is provided with a fixing assembly used for installing the cutting needle, and the cutting needle is inserted into the fixing assembly. A contact sensing assembly used for detecting whether the connecting shaft is separated from the driving shaft or not is installed in the driving shaft and the connecting shaft. The cutting needle is inserted into the fixing assembly, so that the cutting needle is convenient to install; the connecting shaft drives the magnetic attraction of the quick connection assembly to the end of the driving shaft, quick installation of the connecting shaft is achieved, the connecting shaft and the driving shaft can be quickly separated when the cutting needle makes hard contact with the glass slide, damage to the glass slide, the cutting needle and a sample is avoided, waste of precious samples and deviation of experimental data can be avoided, meanwhile, the use cost is reduced, and in addition, the use efficiency is improved. The contact sensing assembly can detect the connecting state of the connecting shaft and the driving shaft.

Description

Technical Field

[0001] This utility model relates to the field of micro-cutting technology, specifically to a detachable needle module for micro-cutting. Background Technology

[0002] In many fields such as biomedical research and pathological diagnosis, it is often necessary to perform precise cutting operations on microscopic samples, such as accurately obtaining specific cell populations or tiny lesions from tissue sections.

[0003] For example, Chinese patent CN110736639A discloses an automated single-cell sampler, including an upright imaging system, a microdissection system, a sample stage system, and a sample extraction system. While this patent offers advantages such as precise cutting of small areas, no impact on cell and tissue activity within the cutting area, simple and convenient operation, high cutting efficiency, and low cost, interference between the cutting needle and sample-carrying devices such as glass slides during the cutting process can still easily cause slide breakage and sample damage, leading to waste of valuable samples and deviations in experimental data.

[0004] For example, Chinese patent CN102607880B discloses a piezoelectric microdissection system, a dissection depth positioning method, and a dissection method. The piezoelectric microdissection system provided by this patent can automatically position itself at any location along the desired depth of biological tissue dissection and can automatically complete the dissection of the target biological tissue, as well as separate the target tissue sections. However, while it controls the force between the dissection needle and the slide through pressure feedback from the piezoelectric ceramic, which avoids slide breakage and sample damage to some extent, it is costly and still presents the problem of inconvenience in cleaning and replacing the dissection needle.

[0005] Based on this, the present invention designs a detachable needle module for micro-cutting to solve the above problems. Utility Model Content

[0006] In view of the above-mentioned shortcomings of the existing technology, the present invention provides a detachable needle module for micro-cutting.

[0007] To achieve the above objectives, this utility model provides the following technical solution:

[0008] A detachable needle module for micro-cutting includes a drive shaft and a cutting needle;

[0009] The drive shaft is connected to a quick-release assembly for quick disassembly and quick assembly;

[0010] The quick-connect component has a connecting shaft;

[0011] The end of the connecting shaft away from the drive shaft is provided with a fixing component for mounting the cutting needle, and the cutting needle is inserted into the fixing component;

[0012] The drive shaft and connecting shaft are equipped with contact sensing components to determine whether the connecting shaft is separated from the drive shaft.

[0013] Furthermore, the quick-connect component includes a magnet, a first mounting slot, and a second mounting slot. The first mounting slot is provided at the end of the drive shaft near the connecting shaft, and a magnet is installed in the first mounting slot. The second mounting slot is provided at the end of the connecting shaft near the drive shaft, and a connecting block that mates with the magnet is installed in the second mounting slot.

[0014] Furthermore, the connecting block can be made of magnet or iron block, and when the connecting block is a magnet, the magnetic poles of the end face of the connecting block near the drive shaft are opposite to the magnetic poles of the end face of the magnet near the connecting shaft.

[0015] Furthermore, the cross-sectional area dimensions of the magnet and the connecting block are the same in the left and right directions.

[0016] Furthermore, the fixing component includes a straight hole and a crimping component. The end of the connecting shaft away from the drive shaft has a straight hole in the vertical direction. The connecting shaft is connected to the crimping component, which moves within the straight hole.

[0017] Furthermore, the inner wall of the knob is fixedly connected with an anti-slip pad.

[0018] Furthermore, the crimping assembly includes a knob, a clamping plate, a transverse groove, a threaded rod, and an arc-shaped groove. The connecting shaft has a transverse groove on the side wall of the straight hole. The clamping plate is slidably connected in the transverse groove. An arc-shaped groove is provided at the end of the clamping plate near the straight hole. The threaded rod is rotatably connected to the end of the clamping plate away from the straight hole. The threaded rod is threadedly connected to the connecting shaft. The knob is fixedly connected to the end of the threaded rod located outside the connecting shaft.

[0019] Furthermore, the contact sensing component includes a positive terminal wire, a negative terminal wire, and a conductive wire. The positive terminal wire and the negative terminal wire are installed inside the drive shaft, and the conductive wire is installed inside the connecting shaft. When the drive shaft and the connecting shaft are in contact, the two ends of the conductive wire are in contact with the ends of the positive terminal wire and the negative terminal wire near the connecting shaft, respectively.

[0020] Beneficial effects

[0021] This invention inserts the cutting needle into the fixed component, facilitating its installation. The connecting shaft drives the magnetic attraction of the quick-connect component to the end of the drive shaft, enabling rapid installation of the connecting shaft. Furthermore, when the cutting needle makes hard contact with the slide, the connecting shaft and drive shaft can be quickly separated, preventing damage to the slide, cutting needle, and sample. This avoids wasting valuable samples and causing experimental data deviations, while also reducing operating costs. In addition, the contact sensing component can detect the connection status of the connecting shaft and drive shaft. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This invention relates to a detachable needle module for micro-cutting in three dimensions. Figure 1 ;

[0024] Figure 2 This is a front view of a detachable needle module for micro-cutting according to the present invention;

[0025] Figure 3 This is a left view of a detachable needle module for micro-cutting according to the present invention;

[0026] Figure 4 This invention relates to a detachable needle module for micro-cutting in three dimensions. Figure 2 ;

[0027] Figure 5 For along Figure 2 A sectional view along the AA direction;

[0028] Figure 6 For along Figure 3 BB direction sectional view;

[0029] Figure 7 for Figure 5 Enlarged view of the structure at point C.

[0030] The labels in the diagram represent:

[0031] 1. Drive shaft 2. Connecting shaft 3. Contact sensing assembly 31. Positive terminal wire 32. Negative terminal wire 33. Conductive wire 4. Fixing assembly 41. Knob 42. Straight hole 43. Anti-slip pad 44. Clamping plate 45. Horizontal groove 46. Threaded rod 47. Arc groove 5. Quick-connect assembly 51. Connecting block 52. Magnet 53. First mounting slot 54. Second mounting slot 6. Cutting needle. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0033] The present invention will be further described below with reference to the embodiments.

[0034] Real-time 1:

[0035] Please refer to the instruction manual appendix. Figure 1-7 A detachable needle module for microcutting includes a drive shaft 1 and a cutting needle 6;

[0036] The drive shaft 1 is connected to a quick-release and quick-installation assembly 5;

[0037] Quick-connect component 5 is connected to connecting shaft 2;

[0038] The end of the connecting shaft 2 away from the drive shaft 1 is provided with a fixing component 4 for mounting the cutting needle 6, and the cutting needle 6 is inserted into the fixing component 4.

[0039] A contact sensing component 3 for determining whether the connecting shaft 2 is separated from the drive shaft 1 is installed inside the drive shaft 1 and the connecting shaft 2.

[0040] The cutting needle 6 is inserted into the fixing component 4 for easy installation. The connecting shaft 2 drives the magnetic attraction of the quick-connect component 5 to the end of the drive shaft 1, enabling quick installation of the connecting shaft 2. When the cutting needle 6 makes hard contact with the glass slide, the connecting shaft 2 and the drive shaft 1 can be quickly separated to avoid damage to the glass slide, cutting needle 6 and sample, thus avoiding waste of precious samples and deviation of experimental data. At the same time, it reduces the cost of use. In addition, the contact sensing component 3 can detect the connection status of the connecting shaft 2 and the drive shaft 1.

[0041] The quick-connect component 5 includes a magnet 52, a first mounting groove 53, a second mounting groove 54, and a connecting block 51. The first mounting groove 53 is provided at the end of the drive shaft 1 near the connecting shaft 2, and the magnet 52 is installed in the first mounting groove 53. The second mounting groove 54 is provided at the end of the connecting shaft 2 near the drive shaft 1, and the connecting block 51 that cooperates with the magnet 52 is installed in the second mounting groove 54. The cross-sectional area of ​​the magnet 52 and the connecting block 51 in the left and right directions is the same.

[0042] The connecting block 51 is made of a magnet or an iron block, and when the connecting block 51 is a magnet, the magnetic pole of the end face of the connecting block 51 near the drive shaft 1 is opposite to the magnetic pole of the end face of the magnet 52 near the connecting shaft 2.

[0043] The connecting shaft 2 drives the magnetic component of the quick-connect assembly 5, the connecting block 51, to attract the magnet 52, enabling the quick installation of the connecting shaft 2 and the drive shaft 1. When the cutting needle 6 makes hard contact with the glass slide, the connecting shaft 2 and the drive shaft 1 can be quickly separated, avoiding damage to the glass slide, the cutting needle 6, and the sample. This avoids the waste of precious samples and the deviation of experimental data, while also reducing the cost of use.

[0044] The fixing component 4 includes a straight hole 42 and a pressing component. The end of the connecting shaft 2 away from the drive shaft 1 has a straight hole 42 in the vertical direction. The connecting shaft 2 is connected to the pressing component, which moves within the straight hole 42.

[0045] An anti-slip pad 43 is fixedly connected to the inner wall of the knob 41;

[0046] The crimping assembly includes a knob 41, a clamping plate 44, a transverse groove 45, a threaded rod 46, and an arc-shaped groove 47. The connecting shaft 2 has a transverse groove 45 on the side wall of the straight hole 42. The clamping plate 44 is slidably connected in the transverse groove 45. The end of the clamping plate 44 near the straight hole 42 has an arc-shaped groove 47. The end of the clamping plate 44 away from the straight hole 42 is rotatably connected to the threaded rod 46. The threaded rod 46 is threadedly connected to the connecting shaft 2. The end of the threaded rod 46 located outside the connecting shaft 2 is fixedly connected to the knob 41.

[0047] Insert the cutting needle 6 into the straight hole 42 of the fixing component 4, and rotate the knob 41 of the pressing component. The knob 41 drives the threaded rod 46 to rotate, and the threaded rod 46 drives the clamping plate 44 to move along the transverse groove 45. The clamping plate 44 drives the arc groove 47 to contact the outer wall of the cutting needle 6, pushing the cutting needle 6 to contact the anti-slip pad 43. The anti-slip pad 43 has elastic deformation capability. The arc groove 47 and the anti-slip pad 43 are conducive to the effective fixing of the cutting needle 6. At the same time, since the position of the arc groove 47 is adjustable, the fixing component 4 can be used with cutting needles 6 of different diameters, which improves adaptability.

[0048] The contact sensing component 3 includes a positive terminal wire 31, a negative terminal wire 32, and a conductive wire 33. The positive terminal wire 31 and the negative terminal wire 32 are installed inside the drive shaft 1, and the conductive wire 33 is installed inside the connecting shaft 2. When the drive shaft 1 and the connecting shaft 2 are in contact, the two ends of the conductive wire 33 are in contact with the ends of the positive terminal wire 31 and the negative terminal wire 32 near the connecting shaft 2, respectively.

[0049] The negative terminal 32 is connected in series with the external warning device, and the positive terminal 31 is connected with the external warning device and the positive and negative terminals of the power supply.

[0050] External warning devices may include strobe lights;

[0051] After the drive shaft 1 and the connecting shaft 2 are connected, the two ends of the conductive wire 33 of the contact sensing component 3 are respectively in contact with the positive terminal 31 and the negative terminal 32 near the end of the connecting shaft 2. The power supply, the external warning device, the positive terminal 31, the negative terminal 32 and the conductive wire 33 form a closed loop. The external warning device will issue a warning. When the connecting shaft 2 is separated from the drive shaft 1, the external warning device will not issue a warning. The connection relationship between the drive shaft 1 and the connecting shaft 2 can be detected in time, which is beneficial for practical use.

[0052] The above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions will not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A detachable needle module for microdissection, comprising a driving shaft (1) and a cutting needle (6), characterized in that: the driving shaft (1) is connected with a quick coupling assembly (5) for quick disassembly and assembly; the quick coupling assembly (5) is connected with a connecting shaft (2); an end of the connecting shaft (2) away from the driving shaft (1) is provided with a fixing assembly (4) for mounting the cutting needle (6), and the cutting needle (6) is inserted into the fixing assembly (4); the driving shaft (1) and the connecting shaft (2) are provided with a contact sensing assembly (3) for sensing whether the connecting shaft (2) is separated from the driving shaft (1).

2. The detachable needle module for microdissection according to claim 1, characterized in that, The quick coupling assembly (5) comprises a magnet (52), a first mounting groove (53) and a second mounting groove (54), an end of the driving shaft (1) close to the connecting shaft (2) is provided with the first mounting groove (53), the first mounting groove (53) is provided with the magnet (52), an end of the connecting shaft (2) close to the driving shaft (1) is provided with the second mounting groove (54), and the second mounting groove (54) is provided with a connecting block (51) matched with the magnet (52).

3. The detachable needle module for microdissection according to claim 2, characterized in that, The connecting block (51) is selected from a magnet or an iron block, and when the connecting block (51) is a magnet, the magnetic pole of an end surface of the connecting block (51) close to the driving shaft (1) is opposite to the magnetic pole of an end surface of the magnet (52) close to the connecting shaft (2).

4. The detachable needle module for microdissection according to claim 2, characterized in that, The cross-sectional area of the magnet (52) and the connecting block (51) in the left-right direction is the same.

5. The detachable needle module for microdissection according to claim 1, characterized in that, The fixing assembly (4) comprises a straight hole (42) and a pressure connecting assembly, an end of the connecting shaft (2) away from the driving shaft (1) is provided with the straight hole (42) in the vertical direction, the connecting shaft (2) is connected with the pressure connecting assembly, and the pressure connecting assembly is movable in the straight hole (42).

6. The detachable needle module for microdissection according to claim 5, characterized in that An inner wall of the knob (41) is fixedly connected with a non-slip pad (43).

7. The detachable needle module for microdissection according to claim 6, characterized in that The pressure connecting assembly comprises the knob (41), a clamping plate (44), a horizontal groove (45), a threaded rod (46) and an arc-shaped groove (47), the connecting shaft (2) is provided with the horizontal groove (45) on the side wall of the straight hole (42), the clamping plate (44) is slidably connected in the horizontal groove (45), an end of the clamping plate (44) close to the straight hole (42) is provided with the arc-shaped groove (47), an end of the clamping plate (44) away from the straight hole (42) is rotatably connected with the threaded rod (46), the threaded rod (46) is threadedly connected with the connecting shaft (2), and an end of the threaded rod (46) outside the connecting shaft (2) is fixedly connected with the knob (41).

8. The detachable needle module for microdissection according to any one of claims 1 to 7, characterized in that The contact sensing assembly (3) comprises a positive electrode wire (31), a negative electrode wire (32) and a conducting wire (33), the positive electrode wire (31) and the negative electrode wire (32) are installed in the driving shaft (1), the conducting wire (33) is installed in the connecting shaft (2), and when the driving shaft (1) and the connecting shaft (2) are in contact, the ends of the conducting wire (33) are in contact with the ends of the positive electrode wire (31) and the negative electrode wire (32) close to the connecting shaft (2).

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