Healthy preparation for treating fungal infection psoriasis and preparation method thereof

Abstract

The invention discloses a healthy preparation for treating fungal infection psoriasis and a preparation method of the healthy preparation. The healthy preparation comprises the following components: 1-3 ml of a mixed solution of water-decocted honeysuckle juice and water-decocted ephedra root juice, 0.2-0.5 g of saccharomycetes and 1-2 g of lactic acid bacteria. The antibacterial preparation is prepared from the edible raw materials without toxic or side effects, is healthy, non-toxic and free of ecological chain harm through activity testing, toxicity testing and fungus inhibition experiment testing, does not cause danger even if being eaten by mistake, is high in safety and is particularly suitable for people with low immunity.

Description

Technical Field

[0001] The invention relates to the technical field of medical supplies, and in particular to a healthy preparation for treating fungal infection psoriasis and a preparation method thereof. Background Art

[0002] Athlete's foot generally refers to tinea pedis, which is a foot skin disease caused by pathogenic fungi and is contagious. There are no sebaceous glands on the soles and between the toes of people, so there is a lack of fatty acids that inhibit skin filamentous fungi, and the physiological defense function is poor. However, the sweat glands in the skin of these parts are very rich, and sweating is relatively frequent. In addition, the air circulation is poor, and the local area is humid and warm, which is conducive to the growth of filamentous fungi. The clinical manifestations are blisters, peeling, cracking, or white and soft skin between the toes. Erosion or thickening and roughness of the skin may also occur, and it may spread to the sole and edge of the foot, and it is very itchy. At present, antifungal drugs on the market include topical drugs, oral drugs, and keratolytic drugs. The most commonly used topical drugs include econazole nitrate spray, compound clotrimazole ointment, luliconazole cream, etc. These topical drugs are irritating to the skin when used, and they cannot be taken orally during use because of their toxicity. If children or people who are not clear about the use method accidentally ingest them, some unknown dangers will occur. For example, the publication number is CN104415138A, and its name is a medicine for treating athlete's foot. The medicine contains alum, which is toxic; the publication number is CN107998168A, and its name is a medicine for treating athlete's foot. The medicine contains alum, which is toxic.

[0003] In summary, the topical medications currently on the market for the treatment of psoriasis contain more or less toxic substances in their ingredients. When people accidentally ingest them, many unpredictable dangers will occur, affecting our lives. Summary of the invention

[0004] The object of the present invention is to provide a formula of a healthy preparation for treating fungal infection psoriasis; Another object of the present invention is to provide a method for preparing the healthy preparation for treating fungal infection psoriasis.

[0005] The technical solution provided according to the embodiment of the present application is as follows: A healthy preparation for treating fungal infection psoriasis, comprising the following components: 1ml-3ml of a mixture of decoction of honeysuckle juice and decoction of ephedra root juice, 0.2-0.5g of yeast, and 1-2g of lactic acid bacteria; wherein the mixing ratio of the decoction of honeysuckle and the decoction of ephedra root is one of 1:4, 1:5, 1:6, and 1:7.

[0006] Yeast and lactic acid bacteria are both dry active bacterial powder purchased from the market.

[0007] A method for preparing a healthy preparation for treating fungal infection psoriasis comprises the following steps: A. Take 5g of honeysuckle, decoct it three times with water until the honeysuckle turns white, and obtain 20ml-25ml of concentrated juice. Cool it to obtain decoction of honeysuckle juice. B. Take 15g-30g of ephedra root, decoct it three times with water until the root becomes crispy, obtain 50ml-100ml of ephedra root concentrated juice, cool it, and obtain decoction of ephedra root juice; C. Mix the concentrated juice of honeysuckle decoction and the concentrated juice of ephedra root decoction in a ratio of 1-3 ml to obtain a mixed solution. First, add 0.2-0.5 g of yeast to the mixed solution and mix well. Then, add 1-2 g of lactic acid bacteria to the mixed solution and mix well.

[0008] In summary, the beneficial effects of the present application are as follows: 1. The present invention adopts non-toxic, non-side-effect-free edible raw materials to make antibacterial preparations. Through activity tests, toxicity tests, and fungal inhibition experimental tests, it is found that the antibacterial preparations are healthy and non-toxic, have no ecological chain hazards, and will not cause danger even if they are eaten by mistake. They are highly safe and are particularly suitable for people with low immunity; 2. The preparation steps of the present invention are simple, the cost is low, and it can be applied to large-scale production. DETAILED DESCRIPTION

[0009] The present application is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the relevant invention, rather than to limit the invention.

[0010] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application may be combined with each other.

[0011] Recipe A Take 5g of honeysuckle, boil it three times with water until the honeysuckle turns white, and obtain 20ml-25ml of concentrated juice. After cooling, obtain decoction of honeysuckle juice; Take 15g of ephedra root, boil it three times with water until the root becomes crispy, and obtain 50ml-100ml of concentrated juice. After cooling, obtain decoction of ephedra root juice; Mix 1 ml of water-decocted honeysuckle juice and water-decocted ephedra root juice in a ratio of 1:4 (i.e., 0.2 ml of water-decocted honeysuckle juice and 0.8 ml of water-decocted ephedra root juice), then add 0.2 g of yeast powder and mix well, then add 1 g of lactic acid bacteria, mix well to obtain Formula A, and refrigerate for later use.

[0012] Recipe B Take 5g of honeysuckle, boil it three times with water until the honeysuckle turns white, and obtain 20ml-25ml of concentrated juice. After cooling, obtain decoction of honeysuckle juice; Take 30g of ephedra root, boil it three times with water until the root becomes crispy, and obtain 50ml-100ml of concentrated juice. After cooling, obtain decoction of ephedra root juice; Mix 1 ml of water-decocted honeysuckle juice and water-decocted ephedra root juice in a ratio of 1:5 (i.e., 0.5 ml of water-decocted honeysuckle juice and 2.5 ml of water-decocted ephedra root juice), then add 0.2 g of yeast powder and mix well, then add 1 g of lactic acid bacteria, mix well to obtain formula B, and refrigerate in the refrigerator for later use.

[0013] Recipe C Take 5g of honeysuckle, boil it three times with water until the honeysuckle turns white, and obtain 20ml-25ml of concentrated juice. After cooling, obtain decoction of honeysuckle juice; Take 30g of ephedra root, boil it three times with water until the root becomes crispy, and obtain 50ml-100ml of concentrated juice. After cooling, obtain decoction of ephedra root juice; Mix 3 ml of water-decocted honeysuckle juice and water-decocted ephedra root juice in a ratio of 1:6 (i.e., 0.43 ml of water-decocted honeysuckle juice and 2.57 ml of water-decocted ephedra root juice), then add 0.5 g of yeast powder and mix well, then add 2 g of lactic acid bacteria, mix well to obtain Formula C, and refrigerate in the refrigerator for later use.

[0014] Recipe D Take 5g of honeysuckle, boil it three times with water until the honeysuckle turns white, and obtain 20ml-25ml of concentrated juice. After cooling, obtain decoction of honeysuckle juice; Take 30g of ephedra root, boil it three times with water until the root becomes crispy, and obtain 50ml-100ml of concentrated juice. After cooling, obtain decoction of ephedra root juice; Mix 3 ml of water-decocted honeysuckle juice and water-decocted ephedra root juice in a ratio of 1:7 (i.e., 0.37 ml of water-decocted honeysuckle juice and 2.63 ml of water-decocted ephedra root juice), then add 0.5 g of yeast powder and mix well, then add 2 g of lactic acid bacteria, mix well to obtain Formula D, and refrigerate in a refrigerator for later use. Example

[0015] Testing of the activity of preparations for the treatment of fungal psoriasis LB medium configuration: peptone 10g, yeast powder 5g, sodium chloride 10g, agar 15g, dilute to 1L with water; After sterilizing in a high pressure steam autoclave for 21 minutes, pour the plate.

[0016] Then operate in a sterile operating platform, take 0.1 ml of formula A, formula B, formula C and formula D and spread them evenly on different plates respectively, do parallel tests, mark them, place them in a constant temperature incubator at 28℃ for 5-6 days, and observe the growth of colonies on the plates.

[0017] Table 1 Activity test table of preparations with different formulations As shown in Table 1, after 0.1 ml of Formula A, Formula B, Formula C and Formula D were smeared on the plate and cultured in a constant temperature incubator, it was found that the number of colonies on the parallel test plates was less than 5, indicating that there were no active strains in the preparations prepared by this scheme. Example

[0018] Toxicity experiment of preparations for treating fungal psoriasis Thirty-two mice were divided into four groups, and then Formula A, Formula B, Formula C and Formula D were administered orally to the four groups of mice, with dosages of 0.1 ml, 0.4 ml, 0.8 and 1 ml, respectively, and a parallel test was performed for each dosage.

[0019] After the administration was completed, the mice were fed normally and observed for three days.

[0020] Table 2 Toxicity test table of preparations for treating fungal psoriasis As shown in Table 2, the oral dose of Formula A, Formula B, Formula C and Formula D reached 1.0 ml, and the mice survived after normal feeding, indicating that the preparations for treating fungal psoriasis are not toxic. Example

[0021] Fungal inhibition test of preparations for treating fungal psoriasis The purchased Sabouraud dextrose agar medium was sterilized and poured into plates, then Trichophyton rubrum (a strain isolated in the laboratory) was inoculated onto the plates and hyphae were cultured in a constant temperature incubator at 28°C.

[0022] Preparation of test plates: After sterilizing the purchased Sabouraud dextrose agar medium, add 0, 0.1%, 1%, 5%, and 10% of formula A, pour the plates, perform parallel experiments, and mark them; After the plate solidified, the cultured Trichophyton rubrum was streaked on the plate with different doses of Formula A using an inoculating loop. After streaking, the plates were cultured in a constant temperature incubator at 28°C, and the number of colonies on the plates was detected.

[0023] Table 3 Fungal inhibition test of the preparations for treating fungal infection psoriasis As shown in Table 3, when the added dosage of formula A is below 1%, the number of colonies on the test plate is greater than 5, and the fungal inhibition is not ideal. When the added dosage is greater than 1%, the number of colonies on the test plate is less than 5, indicating that the fungal inhibition is good. From the above, it can be seen that the preparation for treating fungal infection psoriasis has a good effect of inhibiting the growth of Trichophyton rubrum at a certain dosage. It shows that the preparation for treating fungal infection psoriasis can effectively prevent Trichophyton rubrum from surviving. Since Trichophyton rubrum is a common human psoriasis pathogen and a kind of fungus, it can also be obtained that the preparation for treating fungal infection psoriasis prepared in this scheme can effectively inhibit fungal growth.

[0024] Yeast and lactic acid bacteria are both dry active bacterial powder purchased from the market.

[0025] The above description is only an explanation of the preferred embodiments of the present application and the technical principles and other schemes used. At the same time, the scope of the invention involved in the present application is not limited to the technical scheme formed by a specific combination of the above technical features, but also includes other technical schemes formed by any combination of the above technical features or their equivalent features without departing from the inventive concept. For example, the above features are replaced with the technical features with similar functions disclosed in the present application (but not limited to) to form a technical scheme.

Claims

1. A healthy preparation for treating fungal infection psoriasis, characterized in that: The invention comprises the following components: 1ml-3ml of a mixture of decoction of honeysuckle juice and decoction of ephedra root juice, 0.2-0.5g of yeast and 1-2g of lactic acid bacteria.

2. A healthy preparation for treating fungal psoriasis according to claim 1, characterized in that: The mixing ratio of the decoction of honeysuckle and the decoction of ephedra root is one of 1:4, 1:5, 1:6, and 1:

7.

3. A healthy preparation for treating fungal psoriasis according to claim 1, characterized in that: Yeast and lactic acid bacteria are both dry bacterial powder.

4. The method for preparing the healthy preparation for treating fungal psoriasis according to claim 1, characterized in that: The following steps are involved: A. Take 5g of honeysuckle, decoct it three times with water until the honeysuckle turns white, and obtain 20ml-25ml of concentrated juice. Cool it to obtain decoction of honeysuckle juice. B. Take 15g-30g of ephedra root, decoct it three times with water until the root becomes crispy, obtain 50ml-100ml of ephedra root concentrated juice, cool it, and obtain decoction of ephedra root juice; C. Mix the concentrated juice of honeysuckle decoction and the concentrated juice of ephedra root decoction in a ratio of 1-3 ml to obtain a mixed solution. First, add 0.2-0.5 g of yeast to the mixed solution and mix well. Then, add 1-2 g of lactic acid bacteria to the mixed solution and mix well.