Composition with blood replenishing effect as well as preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine. The invention provides a composition with a blood replenishing effect and a preparation method thereof. The composition comprises the following components in parts by weight: 40-60 parts of raw panax notoginseng fibrous roots, 8-15 parts of angelica sinensis, 12-18 parts of prepared rehmannia roots, 5-10 parts of ligusticum wallichii and 8-13 parts of radix paeoniae alba. According to the preparation method, after soaking in honey water and steaming are carried out together, conversion of saponin components in fibrous roots of panax notoginseng is effectively promoted, and the tonifying effect is improved. According to the composition prepared by the technical scheme, active ingredients are reserved to the maximum extent; meanwhile, all the components have a synergistic effect, so that the content of hemoglobin is obviously increased, erythropoiesis is promoted, the blood replenishing effect is enhanced, the qi and blood level of an organism is improved, the immunity is improved, and symptoms such as anemia and fatigue are favorably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a composition with blood-tonifying effect and a preparation method and application thereof. Background Art

[0002] Panax notoginseng (Panax notoginseng) is a plant of the genus Panax in the family Araliaceae. Its dried roots and rhizomes are used as medicine. It is also known as "Tianqi" and "Jinbuhuan". It has the characteristics of "stopping bleeding without leaving blood stasis, and removing blood stasis without hurting the body". It is a representative medicine for "promoting blood circulation and stopping bleeding" in traditional Chinese medicine. It also has the effect of "raw beating and cooked supplementing".

[0003] The fibrous roots of Panax notoginseng are the lateral roots growing on the main roots and rhizomes, commonly known as hairy roots. They are non-medicinal parts of Panax notoginseng and are byproducts of Panax notoginseng medicinal material processing. They have high economic value and pharmacological activity. Their main active substances are saponins. The types and contents of saponins are similar to those of the main roots of Panax notoginseng, but there are certain differences in the types and proportions. In recent years, the research on the fibrous roots of Panax notoginseng has gradually increased, especially in resource utilization, component analysis and pharmacological research. Studies have found that the fibrous roots of Panax notoginseng are rich in dammarane saponins (such as ginsenoside Rb1, Rd, Re, Panax notoginseng saponin R1, etc.), and the total saponin content is equivalent to or even higher than that of the main roots, but there are differences in the monomer ratio (such as higher Rb1 content and lower Rg1 content). Pharmacological studies have found that the fibrous roots of Panax notoginseng can improve anemia by promoting the proliferation of bone marrow hematopoietic stem cells and regulating the EPO (erythropoietin) pathway. However, so far, there are few studies on cooked Panax notoginseng fibrous roots, and there are also few studies on the use of cooked Panax notoginseng fibrous roots to prepare blood-enriching compositions. Summary of the invention

[0004] The purpose of the present invention is to provide a composition with blood-tonifying effect and a preparation method thereof. The components synergize with each other to significantly enhance the blood-tonifying and nourishing health-preserving effects, improve the body's qi and blood levels, improve immunity, and help improve symptoms such as anemia, fatigue and weakness.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides a composition with blood-tonifying effect, comprising the following components in parts by weight: 40-60 parts of raw Panax notoginseng root, 8-15 parts of Chinese angelica, 12-18 parts of Rehmannia root, 5-10 parts of Chuanxiong and 8-13 parts of white peony root.

[0007] The present invention also provides a method for preparing the composition having the blood-tonifying effect, comprising the following steps:

[0008] (1) soaking raw Panax notoginseng root in honey water, then steaming at 100-120° C. for 3-8 hours, and drying to obtain cooked Panax notoginseng root;

[0009] (2) crushing the Panax notoginseng root fiber obtained in step (1) to obtain Panax notoginseng root fiber powder;

[0010] (3) Mix angelica sinensis, Rehmannia root, Chuanxiong and white peony root, add water, and boil to obtain a mixture 1;

[0011] (4) The cooked Panax notoginseng root powder is mixed with the mixed solution 1 and concentrated to obtain the composition.

[0012] Preferably, the soaking time in step (1) is 2-5 hours, and the soaking temperature is 8-20°C.

[0013] Preferably, the drying time in step (1) is 1-3 hours, and the drying temperature is 40-60°C.

[0014] Preferably, the mass concentration of the honey water in step (1) is 15-25%.

[0015] Preferably, step (2) is crushed to a particle size of 120-150 mesh.

[0016] Preferably, the amount of water added in step (3) is 8-15 times the total mass of Angelica sinensis, Rehmannia root, Ligusticum chuanxiong and Paeonia lactiflora.

[0017] Preferably, the decoction process in step (3) is to first boil over high heat and then continue to decoct over low heat; the decoction time is 25-40 min / time, and the number of decoctions is 2-3 times.

[0018] The present invention also provides application of the composition or the composition prepared by the preparation method in preparing blood-enriching medicine.

[0019] Preferably, the dosage form of the blood-enriching medicine includes granules, capsules or oral liquids.

[0020] By adopting the above technical solution, the present invention has the following beneficial effects:

[0021] 1. In the technical solution of the present invention, the Panax notoginseng roots are treated by soaking in honey water and steaming, which effectively promotes the transformation of saponin components in the Panax notoginseng roots and increases the tonic effect.

[0022] 2. The present invention uses a combination of several Chinese medicinal materials including cooked Panax notoginseng root, Chinese angelica, Rehmannia root, Chuanxiong and white peony root. The components work together to enhance the effect, significantly enhancing blood tonification and nourishing health, while improving the body's Qi and blood levels, achieving the effect of Qi and blood tonification; it can also promote blood circulation, increase the red blood cell content in the blood, improve immunity, and help improve symptoms such as anemia, fatigue and weakness. In addition, the present invention uses the non-medicinal part of Panax notoginseng, namely the Panax notoginseng root, which also realizes the comprehensive development and utilization of resources to a certain extent. DETAILED DESCRIPTION

[0023] The invention provides a composition with blood-tonifying effect, the components of which include raw notoginseng root, angelica, prepared rehmannia root, chuanxiong and white peony root.

[0024] In the present invention, the weight portion of the raw Panax notoginseng root is preferably 40-60 parts, further preferably 45-55 parts, and further preferably 50 parts; the weight portion of the angelica sinensis is preferably 8-15 parts, further preferably 9-12 parts, and further preferably 10 parts; the weight portion of the Rehmannia glutinosa is preferably 12-18 parts, further preferably 13-16 parts, and further preferably 15 parts; the weight portion of the Chuanxiong is preferably 5-10 parts, further preferably 6-9 parts, and further preferably 8 parts; the weight portion of the white peony root is preferably 8-13 parts, further preferably 9-12 parts, and further preferably 10 parts.

[0025] In the present invention, the angelica is a common herb for blood tonic, and the volatile oil and polysaccharide components it contains can promote blood circulation, increase the red blood cell content in the blood, and thus play a role in blood tonic. The prepared rehmannia root of the present invention contains rich nutrients such as mucin, polysaccharide, amino acid, etc., has the effect of nourishing blood, can promote the formation and circulation of blood, increase the content of red blood cells and hemoglobin; it also has the effects of nourishing the heart and calming the mind, moistening the intestines and relieving constipation, delaying aging, and enhancing immunity. In the present invention, the angelica root and the prepared rehmannia root are used in combination to effectively enhance the effect of nourishing blood and nourishing yin.

[0026] In the present invention, the raw Panax notoginseng root has the effect of nourishing blood and replenishing qi, and can improve symptoms such as fatigue, physical weakness, dizziness, palpitations, etc.; it also contains a variety of active ingredients, has antioxidant and anti-inflammatory effects, and can enhance the body's immunity. On the basis that the combination of angelica, Rehmannia root, Chuanxiong and white peony root described in the present invention can effectively enhance the production of red blood cells and the synthesis of hemoglobin, the use of Panax notoginseng root can better achieve the effect of nourishing blood and improving the body's qi and blood levels.

[0027] The present invention also provides a method for preparing the composition having the blood-tonifying effect, comprising the following steps:

[0028] (1) soaking raw Panax notoginseng root in honey water, then steaming at 100-120° C. for 3-8 hours, and drying to obtain cooked Panax notoginseng root;

[0029] (2) crushing the Panax notoginseng root fiber obtained in step (1) to obtain Panax notoginseng root fiber powder;

[0030] (3) Mix angelica sinensis, Rehmannia root, Chuanxiong and white peony root, add water, and boil to obtain a mixture 1;

[0031] (4) The cooked Panax notoginseng root powder is mixed with the mixed solution 1 and concentrated to obtain the composition.

[0032] In the present invention, after washing the raw Panax notoginseng rootlets, removing the surface moisture, and soaking them in honey water, preferably until the raw Panax notoginseng rootlets are completely immersed in the honey water. The mass concentration of the honey water of the present invention is preferably 15-25%, further preferably 17-23%, and further preferably 20%; the soaking time is preferably 2-5h, further preferably 2.5-4.8h, and further preferably 4h; the soaking temperature is preferably 8-20°C, further preferably 9-15°C, and further preferably 12°C. This cooking treatment in the present invention promotes the transformation of saponin active ingredients in the raw Panax notoginseng rootlets, and the transformation effect is good. The mass concentration of honey water of the present invention can not only ensure a good penetration effect, promote the transformation of active ingredients such as saponins, but also avoid the difficulty of penetration at low temperatures due to excessive viscosity.

[0033] In the present invention, the soaked raw Panax notoginseng root is steamed and then dried to obtain cooked Panax notoginseng root. The steaming temperature of the present invention is preferably 100-120°C, more preferably 102-115°C, and more preferably 108°C; the steaming time is preferably 3-8h, more preferably 3.5-7h, and more preferably 5h. The drying time of the present invention is preferably 1-3h, more preferably 1.2-2.5h, and more preferably 2h; the drying temperature is preferably 40-60°C, more preferably 45-55°C, and more preferably 50°C.

[0034] In the present invention, the cooked Panax notoginseng root is crushed to obtain the cooked Panax notoginseng root powder. Preferably, the present invention crushes to a particle size of 120-150 mesh, more preferably 125-140 mesh, and more preferably 130 mesh. After the crushing of the present invention, it is preferably sieved to collect the undersize to obtain.

[0035] In the present invention, angelica, Rehmannia root, Chuanxiong and white peony root are mixed and water is added, and the mixture is decocted to obtain a mixed solution 1. The amount of water added in the present invention is preferably 8-15 times the total mass of angelica, Rehmannia root, Chuanxiong and white peony root, further preferably 9-14 times, and further preferably 11 times. The decoction process of the present invention is to first boil with high heat and then continue to decoct with low heat; the decoction time is preferably 25-40min / time, further preferably 28-38min / time, and further preferably 32min / time; the number of decoctions is preferably 2-3 times, and further preferably 3 times. In the present invention, it is preferred that each decoction is filtered, the filtrate is collected, and the filtrate is combined to obtain a mixed solution 1.

[0036] In the present invention, the cooked Panax notoginseng root powder is mixed with the mixed solution 1 and concentrated to obtain the composition. The present invention preferably concentrates the mixture to 0.5-1 g / mL, and further concentrates the mixture to 0.8 g / mL.

[0037] The invention also provides application of the composition in preparing blood-enriching medicine.

[0038] In the present invention, the dosage form of the blood-enriching medicine includes granules, capsules or oral liquids.

[0039] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0040] Example 1

[0041] A composition with blood-tonifying effect comprises: 50 parts of raw Panax notoginseng root, 10 parts of Chinese angelica, 15 parts of Rehmannia root, 8 parts of Chuanxiong and 10 parts of white peony root.

[0042] Example 2

[0043] A composition with blood-tonifying effect comprises: 40 parts of raw Panax notoginseng root, 15 parts of Chinese angelica, 12 parts of Rehmannia root, 5 parts of Chuanxiong and 13 parts of white peony root.

[0044] Example 3

[0045] A composition with blood-tonifying effect comprises: 60 parts of raw Panax notoginseng root, 8 parts of Chinese angelica, 18 parts of Rehmannia root, 10 parts of Chuanxiong and 8 parts of white peony root.

[0046] Example 4

[0047] A method for preparing the composition having the blood-tonifying effect as described in Example 1 comprises the following steps:

[0048] (1) After washing the raw Panax notoginseng rootlets, remove the surface moisture, soak them in honey water with a mass concentration of 20% until they are completely immersed, and soak them at 12° C. for 4 hours; then steam them at 108° C. for 5 hours, and dry them at 50° C. for 2 hours to obtain cooked Panax notoginseng rootlets;

[0049] (2) crushing the cooked Panax notoginseng root to a particle size of 130 mesh, sieving, and collecting the sieved material to obtain the cooked Panax notoginseng root powder;

[0050] (3) Mix angelica sinensis, Rehmannia root, Chuanxiong and white peony root, and add 11 times the total weight of water to boil the mixture. First, boil over high heat and then continue to boil over low heat for 32 min each time. Boil for 3 times in total. Filter after each decoction, collect the filtrate, and combine them to obtain mixed solution 1.

[0051] (4) The cooked Panax notoginseng root powder is mixed with the mixed solution 1 and concentrated to obtain the composition.

[0052] Example 5

[0053] A method for preparing the composition having the blood-tonifying effect as described in Example 1 comprises the following steps:

[0054] (1) After washing the raw Panax notoginseng rootlets, remove the surface moisture, soak them in honey water with a mass concentration of 15% until they are completely immersed, and soak them at 8°C for 5 hours; then steam them at 100°C for 8 hours, and dry them at 40°C for 3 hours to obtain cooked Panax notoginseng rootlets;

[0055] (2) crushing the cooked Panax notoginseng root to a particle size of 120 mesh, sieving, and collecting the sieved material to obtain the cooked Panax notoginseng root powder;

[0056] (3) Mix angelica sinensis, Rehmannia root, Chuanxiong and white peony root, and add 9 times the total weight of water to boil the mixture. First, boil over high heat and then continue to boil over low heat for 25 min each time. Boil for 3 times in total. Filter after each decoction, collect the filtrate, and combine them to obtain mixed solution 1.

[0057] (4) The cooked Panax notoginseng root powder is mixed with the mixed solution 1 and concentrated to obtain the composition.

[0058] Example 6

[0059] A method for preparing the composition having the blood-tonifying effect as described in Example 1 comprises the following steps:

[0060] (1) After washing the raw Panax notoginseng rootlets, remove the surface moisture, soak them in honey water with a mass concentration of 25% until they are completely immersed, and soak them at 15° C. for 4 hours; then steam them at 120° C. for 3 hours, and dry them at 60° C. for 1 hour to obtain cooked Panax notoginseng rootlets;

[0061] (2) crushing the cooked Panax notoginseng root to a particle size of 150 mesh, sieving, and collecting the sieved material to obtain the cooked Panax notoginseng root powder;

[0062] (3) Mix angelica sinensis, Rehmannia root, Chuanxiong and white peony root, and add 15 times the total weight of water to boil the mixture. First, boil over high heat and then continue to boil over low heat for 40 min each time. Boil for 2 times in total. Filter after each decoction, collect the filtrate, and combine them to obtain mixed solution 1.

[0063] (4) The cooked Panax notoginseng root powder is mixed with the mixed solution 1 and concentrated to obtain the composition.

[0064] Example 7

[0065] A method for preparing the composition having the blood-tonifying effect as described in Example 2 comprises the following steps:

[0066] (1) After washing the raw Panax notoginseng rootlets, remove the surface moisture, soak them in honey water with a mass concentration of 20% until they are completely immersed, and soak them at 12° C. for 4 hours; then steam them at 108° C. for 5 hours, and dry them at 50° C. for 2 hours to obtain cooked Panax notoginseng rootlets;

[0067] (2) crushing the cooked Panax notoginseng root to a particle size of 130 mesh, sieving, and collecting the sieved material to obtain the cooked Panax notoginseng root powder;

[0068] (3) Mix angelica sinensis, Rehmannia root, Chuanxiong and white peony root, and add 11 times the total weight of water to boil the mixture. First, boil over high heat and then continue to boil over low heat for 32 min each time. Boil for 3 times in total. Filter after each decoction, collect the filtrate, and combine them to obtain mixed solution 1.

[0069] (4) Mixing the cooked Panax notoginseng root powder with the mixed solution 1 and concentrating the mixture to obtain the composition.

[0070] Example 8

[0071] A method for preparing the composition having the blood-tonifying effect as described in Example 3 comprises the following steps:

[0072] (1) After washing the raw Panax notoginseng rootlets, remove the surface moisture, soak them in honey water with a mass concentration of 20% until they are completely immersed, and soak them at 12° C. for 4 hours; then steam them at 108° C. for 5 hours, and dry them at 50° C. for 2 hours to obtain cooked Panax notoginseng rootlets;

[0073] (2) crushing the cooked Panax notoginseng root to a particle size of 130 mesh, sieving, and collecting the sieved material to obtain the cooked Panax notoginseng root powder;

[0074] (3) Mix angelica sinensis, Rehmannia root, Chuanxiong and white peony root, and add 11 times the total weight of water to boil the mixture. First, boil over high heat and then continue to boil over low heat for 32 min each time. Boil for 3 times in total. Filter after each decoction, collect the filtrate, and combine them to obtain mixed solution 1.

[0075] (4) Mixing the cooked Panax notoginseng root powder with the mixed solution 1 and concentrating the mixture to obtain the composition.

[0076] Comparative Example 1

[0077] The same as Example 4, only the method of “wash the raw Panax notoginseng rootlets, remove the surface moisture, soak them in honey water with a mass concentration of 20% until they are completely immersed, and soak them at 12°C for 4 hours; then steam them at 108°C for 5 hours, and dry them at 50°C for 2 hours to obtain cooked Panax notoginseng rootlets” is replaced with “wash the raw Panax notoginseng rootlets, remove the surface moisture, then steam them at 108°C for 5 hours, and dry them at 50°C for 2 hours to obtain cooked Panax notoginseng rootlets”.

[0078] Comparative Example 2

[0079] The same as Example 4, except that Panax notoginseng root was not added.

[0080] Comparative Example 3

[0081] Same as Example 4, only "50 parts of raw Panax notoginseng roots, 10 parts of Chinese angelica, 15 parts of Rehmannia root prepared, 8 parts of Chuanxiong, and 10 parts of white peony root" is replaced by "20 parts of raw Panax notoginseng roots, 5 parts of Chinese angelica, 5 parts of Rehmannia root prepared, 2 parts of Chuanxiong, and 2 parts of white peony root".

[0082] Test Example 1

[0083] SPF BALB / c mice, half male and half female (5 weeks old) weighing 18-22 g, were purchased from Yusibeifu (Beijing) Biotechnology Co., Ltd. (Beijing) Co., Ltd. (China) and raised in the SPF Experimental Animal Center of Kunming Medical University. They were kept in the same room with a room temperature of 25±1°C and a relative humidity of (55±5)%, maintaining a 12h light / 12h dark cycle, and turning on the lights at 7 am. During the study, mice were allowed to eat standard food and water at will. The mice were allowed to adapt to the environment for one week before being used in the experiment. (one)

[0085] 20 mice were randomly selected and divided into two groups, namely the test group and the control group. The test group was given the composition solution (1 g / mL) of the present invention by oral gavage at a dosage volume of 0.3 mL / 10 g; while the control group was given normal saline by oral gavage at the same volume. The mice were observed for 14 consecutive days, and the autonomous activity, respiration, pupil size, secretions, etc. were recorded.

[0086] The results showed that the autonomous activities, breathing, pupil size, secretions, etc. of the mice in the test group and the control group were the same, and there were no abnormal symptoms, which indicates that the composition of the present invention is non-toxic. (two)

[0088] The above experimental mice were randomly divided into 7 groups, with 6 mice in each group, namely blank control group, model group, positive control group, Example 4 group, Comparative Example 1 group, Comparative Example 2 group and Comparative Example 3 group.

[0089] Except for the blank group, the other groups were intraperitoneally injected with CTX 40 mg / kg (cyclophosphamide, purchased from Shanghai Yuanye Biotechnology Co., Ltd.), once a day, for 4 consecutive days, and gavage was started at the same time as modeling. The positive control group was subcutaneously injected with EPO (1500 IU / kg) (recombinant human erythropoietin, purchased from North China Pharmaceutical) on the first day of modeling and given the drug at the same time, once every other day, for a total of 5 times; Example 4 group, Comparative Example 1 group, Comparative Example 2 group and Comparative Example 3 group were respectively given the composition drug prepared by the preparation method of the corresponding group, and the dosage was 727.5 mg / kg, once a day, for 11 days.

[0090] After the first administration, blood was collected from the eye sockets, and the concentrations of WBC (white blood cells), RBC (red blood cells), HCT (hematocrit), HGB (hemoglobin concentration), and PLT (platelet) were measured by a fully automatic blood analyzer. The results are shown in Table 1.

[0091] Table 1 Concentrations of WBC, RBC, HCT, HGB and PLT in peripheral blood of different groups

[0092] Group <![CDATA[WBC(10 9 / L)]]> <![CDATA[RBC(10 12 / L)]]> HCT(%) HGB(g / L) <![CDATA[PLT(10 9 / L) <!-- 5 -->]]> Blank control group 7.84 8.75 46.07 156.42 74.18 Model Group 12.21 7.16 35.86 138.21 75.60 Positive control group 18.75 9.13 52.14 175.63 223.54 Example 4 Group 16.12 8.30 44.95 153.07 211.35 Comparative Example 1 15.33 7.91 42.32 150.18 206.45 Comparative Example 2 14.05 7.82 40.63 145.37 191.08 Comparative Example 3 14.93 7.85 41.75 148.34 198.26

[0093] According to Table 1, compared with the model group, the WBC, RBC, HCT, HGB and PLT concentrations in the peripheral blood of mice were significantly increased in the Example 4 group and the Comparative Examples 1-3 groups, indicating that the use of the composition of the present invention can effectively increase the hemoglobin content, increase the red blood cell count and hematocrit, improve the level of qi and blood, achieve the effect of blood supplementation, improve anemia symptoms, and enhance the body's immunity. Compared with the combination of Angelica sinensis, Rehmannia glutinosa, Chuanxiong and Paeonia lactiflora, the addition of the cooked Panax notoginseng root produced a synergistic effect with the above four components, and further promoted the transformation of the chemical components in the Panax notoginseng root.

[0094] In summary, it can be seen that the technical solution of the present invention significantly increases the hemoglobin content, promotes erythropoiesis, enhances the blood-tonifying effect, improves the body's qi and blood levels, improves immunity, and helps to improve symptoms such as anemia, fatigue, etc. through synergistic enhancement between the components.

[0095] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A composition having the effect of enriching blood, characterized in that: The invention comprises the following components in parts by weight: 40-60 parts of raw Panax notoginseng root, 8-15 parts of Chinese angelica root, 12-18 parts of Rehmannia root, 5-10 parts of Chuanxiong rhizome and 8-13 parts of white peony root.

2. A method for preparing the composition having blood-tonifying effect according to claim 1, characterized in that: The steps include: (1) soaking raw Panax notoginseng root in honey water, then steaming at 100-120° C. for 3-8 hours, and drying to obtain cooked Panax notoginseng root; (2) crushing the Panax notoginseng root fiber obtained in step (1) to obtain Panax notoginseng root fiber powder; (3) Mix angelica sinensis, Rehmannia root, Chuanxiong and white peony root, add water, and boil to obtain a mixture 1; (4) Mixing the cooked Panax notoginseng root powder with the mixed solution 1 and concentrating the mixture to obtain the composition.

3. The preparation method according to claim 2, characterized in that: The soaking time in step (1) is 2-5 hours, and the soaking temperature is 8-20°C.

4. The preparation method according to claim 2, characterized in that: The drying time in step (1) is 1-3 hours, and the drying temperature is 40-60°C.

5. The preparation method according to claim 2, characterized in that: The mass concentration of the honey water in step (1) is 15-25%.

6. The preparation method according to claim 2, characterized in that: Step (2) crushing to a particle size of 120-150 mesh.

7. The preparation method according to claim 2, characterized in that: The amount of water added in step (3) is 8-15 times the total mass of angelica sinensis, rehmannia root, ligusticum chuanxiong and white peony root.

8. The preparation method according to claim 2, characterized in that: The decoction process in step (3) is to first boil over high heat and then continue to decoct over low heat; the decoction time is 25-40 minutes / time, and the number of decoctions is 2-3 times.

9. Use of the composition according to claim 1 or the composition prepared by the preparation method according to any one of claims 2 to 8 in the preparation of blood-enriching drugs.

10. The use according to claim 9, characterized in that: The dosage form of the blood-enriching medicine includes granules, capsules or oral liquids.