Smart and intelligence-promoting paste and preparation method thereof

Abstract

The invention belongs to the field of traditional Chinese medicine, and discloses an intelligent paste and a preparation method thereof, the intelligent paste comprises the following traditional Chinese medicinal materials: 10g of fructus alpiniae oxyphyllae, 6g of rhizoma acori graminei, 6g of polygala tenuifolia, 20g of mulberry fruit for nourishing yin and soothing nerves, 6g of schisandra chinensis, 10g of prepared rehmannia root, 10g of fried spina date seed, 10g of scorched hawthorn fruit, 15g of scorched malt, 10g of scorched medicated leaven, 10g of fried endothelium corneum gigeriae galli, 6g of radix bupleuri, 10g of radix curcumae, 10g of black sesame, 10g of pulp of dogwood fruit, 10g of angelica sinensis, 15g of astragalus membranaceus, 15g of calcined dragon bone and 15g of calcined oyster shell; and the flavoring and paste collecting auxiliary materials comprise 200 g of honey and 100 g of rock sugar. The traditional Chinese medicine ointment has the following effects of benefiting intelligence, inducing resuscitation and enhancing memory; yin nourishing, nerve soothing and sleep quality improving are achieved; the spleen is strengthened to promote digestion, and inappetence is improved; and soothing liver-qi stagnation and relieving psychological stress.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a congming yizhi ointment and a preparation method thereof. Background Art

[0002] Data shows that about 15% of children aged 6-17 worldwide have attention deficit or hyperactivity tendencies (ADHD-related symptoms), excessive use of electronic devices leads to chronic fatigue of brain nerves, and the fast food diet structure causes spleen deficiency and poor appetite.

[0003] Traditional chemical drugs (such as methylphenidate) have the risk of dependence and growth inhibition side effects. Summary of the invention

[0004] In order to overcome the above technical problems, the present invention provides a smart and intelligent ointment and a preparation method thereof.

[0005] The present invention adopts the following technical solutions:

[0006] Smart ointment is composed of the following ingredients by weight:

[0007] Chinese medicinal materials: Alpinia oxyphylla 10g, Acorus gramineus 6g, Polygala tenuifolia 6g, nourishing yin and calming the mind: Morus alba 20g, Schisandra chinensis 6g, Rehmannia glutinosa 10g, stir-fried Ziziphus jujuba seeds 10g, charred hawthorn 10g, charred malt 15g, charred Shenqu 10g, stir-fried chicken gizzard 10g, Bupleurum 6g, Curcuma aromatica 10g, black sesame 10g, Cornus officinalis 10g, Angelica sinensis 10g, Astragalus membranaceus 15g, calcined dragon bone 15g, calcined oyster shell 15g;

[0008] Auxiliary materials for flavor correction and paste tightening: 200g honey, 100g rock sugar.

[0009] The preparation method of the smart intelligence-enhancing ointment comprises:

[0010] (1) Pretreatment of medicinal materials

[0011] Washing of medicinal pieces: Rinse all medicinal pieces except black sesame with running water to remove dust on the surface;

[0012] Stir-frying black sesame seeds: spread the black sesame seeds evenly on an iron pan, stir-fry over low heat until they turn slightly yellow and become fragrant, then remove from heat and let cool immediately;

[0013] Mineral processing: crush calcined dragon bones and calcined oysters into soybean size;

[0014] (2) Decoction and extraction

[0015] First decoction: Soak the herbs (except Semen Ziziphi Spinosae and Schisandrae Chinensis) in 8 times the amount of cold water for 40 minutes, boil over high heat, then switch to low heat to keep it slightly boiling, decoct for 90 minutes, and filter the juice;

[0016] Second decoction: add 6 times the amount of hot water to the residue, boil over high heat, add Ziziphus jujuba seeds and Schisandra chinensis (to prevent loss of volatile oil), simmer for 60 minutes over low heat, and filter to obtain the juice;

[0017] Third decoction: add 4 times the amount of hot water to the residue, boil for 40 minutes, filter and combine the three decoctions;

[0018] During the cooking process, use a bamboo stirring stick to stir gently clockwise 3 times to avoid sticking to the bottom.

[0019] (3) Concentrated cream

[0020] Concentration: Filter the combined liquid with a 100-mesh sieve, pour into a stainless steel sandwich pot, boil over high heat, then turn to medium heat for open evaporation, and concentrate until the volume of the liquid is 1 / 3 of the original volume;

[0021] Honey refining: Heat the honey to 116-118℃ (stringy state) in another pot, add rock sugar and boil until it turns amber, then mix with the concentrated liquid medicine;

[0022] Simmer the paste: Keep the temperature in the pot at 90-95℃, stir clockwise with a copper spoon until the paste is in the shape of a "hanging flag";

[0023] (4) Filling

[0024] When the paste temperature drops to 70-80℃, quickly put it into a sterilized brown glass bottle, cover the bottle mouth with food-grade PE film, tighten the bottle cap and turn it upside down for 30 minutes, use the residual heat to form a negative pressure seal, and store it in a cool place away from light.

[0025] Preferably, the angelica and astragalus are soaked in advance: spray the surface with rice wine before the first decocting and let it stand for 20 minutes to soften the fibrous tissue.

[0026] Preferably, 0.5% citric acid solution (based on the amount of water) is added during the third decoction to promote the dissolution of mineral components.

[0027] Preferably, a gradient concentration technology is used during concentration: in the initial concentration stage (specific gravity 1.10-1.15), the steam pressure is maintained at 0.15 MPa and the evaporation rate is controlled at 2 L / h; in the intermediate concentration stage (specific gravity 1.20-1.25), a double-layer condensation reflux device is used to recover volatile components.

[0028] Preferably, the temperature of the honey refining stage is controlled in stages: 80°C for melting honey → 100°C for breaking crystals → 116-118°C for drawing, and the temperature difference in each stage does not exceed 2°C.

[0029] Preferably, the stirring rate is linked to the viscosity of the paste during the cream collection process: a step-by-step speed reduction from 60 rpm at the beginning to 40 rpm at the middle stage to 20 rpm at the end.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] Improves intelligence and memory

[0032] Core medicinal materials: Alpinia oxyphylla, Acorus calamus, Polygala tenuifolia; Alpinia oxyphylla: warms the kidney and consolidates the essence, enhances brain power, and can improve memory loss; Acorus calamus and Polygala tenuifolia: open the mind and dissipate phlegm, connect the heart and kidney, and awaken the mind and improve intelligence; Calcinated dragon bone and calcined oyster: suppress yang and calm the mind, consolidate the essence, and relieve the distraction caused by brain overdraft;

[0033] Nourishes Yin and calms the mind, improving sleep quality

[0034] Core ingredients: mulberry fruit, schisandra chinensis, rehmannia root, stir-fried spiny jujube kernel; mulberry fruit and rehmannia root: nourish yin and blood, replenish kidney essence, and treat yin deficiency and irritability caused by excessive brain use; schisandra chinensis and stir-fried spiny jujube kernel: calm the mind, regulate nerve excitability, and relieve insomnia and dreaminess; black sesame: nourish the liver and kidney, benefit essence and blood, and work with mulberry fruit to enhance brain marrow nutrition;

[0035] Strengthen the spleen and digest food, improve loss of appetite

[0036] Core medicinal materials: charred hawthorn, charred malt, charred Shenqu (collectively known as "Jiao Sanxian"), and stir-fried chicken gizzard lining; Jiao Sanxian: helps digestion and resolves stagnation, promotes spleen and stomach function, and resolves poor appetite and indigestion; stir-fried chicken gizzard lining: strengthens the stomach and digests food, enhances nutrient absorption, and provides an energy basis for mental activity; Astragalus and Cornus officinalis: replenishes qi and consolidates the exterior, astringes semen, and prevents deficiency of qi and blood caused by spleen deficiency;

[0037] Soothe liver and relieve depression, relieve psychological pressure

[0038] Core medicinal materials: Bupleurum, Curcuma, and Angelica; Bupleurum and Curcuma: soothe the liver and promote qi circulation, relieve depression and calm the mind, and regulate anxiety caused by liver qi stagnation; Angelica: replenishes blood and promotes blood circulation, improves fatigue and decreased concentration caused by poor qi and blood circulation. DETAILED DESCRIPTION

[0039] The embodiments of the present invention are described in detail below. Unless otherwise specified, the raw materials and equipment used can be purchased from the market or are commonly used in the art. The methods in the embodiments, unless otherwise specified, are conventional methods in the art. The embodiments described below are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0040] Smart ointment is composed of the following ingredients by weight:

[0041] Chinese medicinal materials: Alpinia oxyphylla 10g, Acorus gramineus 6g, Polygala tenuifolia 6g, nourishing yin and calming the mind: Morus alba 20g, Schisandra chinensis 6g, Rehmannia glutinosa 10g, stir-fried Ziziphus jujuba seeds 10g, charred hawthorn 10g, charred malt 15g, charred Shenqu 10g, stir-fried chicken gizzard 10g, Bupleurum 6g, Curcuma aromatica 10g, black sesame 10g, Cornus officinalis 10g, Angelica sinensis 10g, Astragalus membranaceus 15g, calcined dragon bone 15g, calcined oyster shell 15g;

[0042] Auxiliary materials for flavor correction and paste tightening: 200g honey, 100g rock sugar.

[0043] The preparation method of the smart intelligence-enhancing ointment comprises:

[0044] Pretreatment of medicinal materials

[0045] Washing of medicinal pieces: Rinse all medicinal pieces except black sesame with running water to remove dust on the surface;

[0046] Stir-frying black sesame seeds: spread the black sesame seeds evenly on an iron pan, stir-fry over low heat until they turn slightly yellow and become fragrant, then remove from heat and let cool immediately;

[0047] Mineral processing: crush calcined dragon bones and calcined oysters into soybean size;

[0048] Decoction extraction

[0049] Pre-soak the angelica and astragalus: spray the surface with rice wine before the first decoction and let it stand for 20 minutes to soften the fibrous tissue;

[0050] First decoction: Soak the herbs (except Semen Ziziphi Spinosae and Schisandrae Chinensis) in 8 times the amount of cold water for 40 minutes, boil over high heat, then switch to low heat to keep it slightly boiling, decoct for 90 minutes, and filter the juice;

[0051] Second decoction: add 6 times the amount of hot water to the residue, boil over high heat, add Ziziphus jujuba seeds and Schisandra chinensis (to prevent loss of volatile oil), simmer for 60 minutes over low heat, and filter to obtain the juice;

[0052] Third decoction: add 4 times the amount of hot water to the residue, add 0.5% citric acid solution (based on the amount of water) to promote the dissolution of mineral components, decoct for 40 minutes, filter and combine the three decoctions;

[0053] During the cooking process, use a bamboo stirring stick to stir gently clockwise 3 times to avoid sticking to the bottom.

[0054] Concentrated cream

[0055] Concentration: The combined liquid medicine is filtered through a 100-mesh sieve, poured into a stainless steel sandwich pot, boiled over high heat, then evaporated over medium heat in an open oven, and concentrated to a volume of 1 / 3 of the original volume; gradient concentration technology is used: initial concentration stage (specific gravity 1.10-1.15): maintain steam pressure at 0.15MPa, and control evaporation rate at 2L / h; intermediate concentration stage (specific gravity 1.20-1.25): use a double-layer condensation reflux device to recover volatile components;

[0056] Honey refining: Heat the honey in another pot to 116-118℃ for drawing, and control the temperature in stages: 80℃ for melting honey → 100℃ for breaking crystals → 116-118℃ for drawing, with the temperature difference of each stage not exceeding 2℃. Add rock sugar and boil until it turns amber, then mix with concentrated liquid medicine;

[0057] Slow fire to collect the paste: keep the temperature in the pot at 90-95℃, stir clockwise with a copper spoon at a constant speed, and the stirring speed is linked to the viscosity of the paste: initial 60rpm → mid-term 40rpm → late 20rpm step-by-step speed reduction, until the paste is in a "hanging flag" shape;

[0058] Filling

[0059] When the paste temperature drops to 70-80℃, quickly put it into a sterilized brown glass bottle, cover the bottle mouth with food-grade PE film, tighten the bottle cap and turn it upside down for 30 minutes, use the residual heat to form a negative pressure seal, and store it in a cool place away from light.

[0060] This Chinese medicine ointment is suitable for children and adolescents who are under great study pressure and mental overdraft, with symptoms such as forgetfulness, poor appetite, and disturbed sleep.

[0061] Contraindications: Stop taking the medicine if you have a hot constitution (easily get angry, constipated) or have a fever caused by external factors; adjust the dosage under the guidance of a physician.

[0062] Dosage recommendations: Take with warm water between 5-7 pm (when the kidney meridian is in season), follow a regular schedule, and avoid spicy and greasy foods.

[0063] Randomized, double-blind, placebo-controlled trial;

[0064] Sample size: 120 cases (children and adolescents aged 6-18 years, meeting the diagnostic criteria of "inattention, memory loss, and disturbed sleep");

[0065] Grouping: 60 cases in the experimental group (congmingyizhi cream) vs 60 cases in the control group (placebo cream);

[0066] Treatment course: 10g once a day for 8 weeks, and follow-up for 4 weeks after stopping the medication;

[0067] Evaluation Metrics:

[0068] Attention and concentration (SNAP-IV scale score);

[0069] memory (Wechsler Memory Scale score);

[0070] Sleep quality (Pittsburgh Sleep Quality Index PSQI);

[0071] Digestive function (TCM syndrome score: improvement rate of poor appetite and abdominal distension);

[0072] Safety (liver and kidney function, adverse reaction records).

[0073] result

[0074] Improvements in attention and memory:

[0075] Index Experimental group (before treatment → after treatment) Control group (before treatment → after treatment) P value (inter-group comparison) SNAP-IV attention score 28.5±3.2→18.1±2.8* 28.7±3.0→26.4±3.1 <0.01

[0076] Wechsler Memory Scale score 85.2±6.5→102.3±7.8* 84.9±6.1→89.5±6.3 <0.01

[0077] Sleep and digestive function:

[0078] Sleep quality (PSQI total score):

[0079] Experimental group: 12.5±2.1→6.3±1.9 (improvement rate 79.2%)

[0080] Control group: 12.7±2.3→11.8±2.1 (improvement rate 7.1%)

[0081] Improvement rate of poor appetite: 86.7% in the experimental group vs 23.3% in the control group (P<0.01)

[0082] Safety Data

[0083] Adverse reactions: 3 cases in the experimental group (mild diarrhea in 2 cases, dry mouth in 1 case) and 1 case in the control group (rash), and none of them discontinued treatment.

[0084] Liver and kidney function: There was no statistical difference between the two groups before and after treatment (P>0.05).

[0085] Typical Case Summary

[0086] Case: A 12-year-old boy complained of distraction in class, difficulty reciting, difficulty sleeping, and poor appetite.

[0087] Before treatment: SNAP-IV score was 29 points (normal <18), PSQI score was 13 points, and Wechsler memory score was 82.

[0088] After treatment: After taking Smart Yizhi Cream for 8 weeks, SNAP-IV dropped to 16 points, PSQI 5 points, memory improved to 105 points, and appetite returned to normal.

[0089] Follow-up: The effect was stable and there was no recurrence 4 weeks after stopping the medication.

[0090] Congming Yizhi Paste significantly improves attention, memory and sleep quality (total effective rate 86.6%), which may be achieved through the synergistic regulation of the "heart-kidney-spleen" axis by multiple ingredients (such as Yizhiren nourishing the kidney, Ziziphus jujuba seed calming the nerves, and Jiao Sanxian strengthening the spleen).

[0091] Safety: Few and mild adverse reactions, suitable for long-term conditioning in children.

[0092] Although the embodiments of the present invention have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the above embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. Smart and intelligent ointment, characterized in that: By mass ratio, it is composed of the following ingredients: Chinese medicinal materials: Alpinia oxyphylla 10g, Acorus gramineus 6g, Polygala tenuifolia 6g, nourishing yin and calming the mind: Morus alba 20g, Schisandra chinensis 6g, Rehmannia glutinosa 10g, stir-fried Ziziphus jujuba seeds 10g, charred hawthorn 10g, charred malt 15g, charred Shenqu 10g, stir-fried chicken gizzard 10g, Bupleurum 6g, Curcuma aromatica 10g, black sesame 10g, Cornus officinalis 10g, Angelica sinensis 10g, Astragalus membranaceus 15g, calcined dragon bone 15g, calcined oyster shell 15g; Auxiliary materials for flavor correction and paste tightening: 200g honey, 100g rock sugar.

2. The preparation method of the smart and intelligent ointment is characterized in that: include: (1) Pretreatment of medicinal materials Washing of medicinal pieces: Rinse all medicinal pieces except black sesame with running water to remove dust on the surface; Stir-frying black sesame seeds: spread the black sesame seeds evenly on an iron pan, stir-fry over low heat until they turn slightly yellow and become fragrant, then remove from heat and let cool immediately; Mineral processing: crush calcined dragon bones and calcined oysters into soybean size; (2) Decoction and extraction First decoction: Soak the herbs (except Semen Ziziphi Spinosae and Schisandrae Chinensis) in 8 times the amount of cold water for 40 minutes, boil over high heat, then switch to low heat to keep it slightly boiling, decoct for 90 minutes, and filter the juice; Second decoction: add 6 times the amount of hot water to the residue, boil over high heat, add Ziziphus jujuba seeds and Schisandra chinensis (to prevent loss of volatile oil), simmer for 60 minutes over low heat, and filter to obtain the juice; Third decoction: add 4 times the amount of hot water to the residue, boil for 40 minutes, filter and combine the three decoctions; During the cooking process, use a bamboo stirring stick to stir gently clockwise 3 times to avoid sticking to the bottom. (3) Concentrated cream Concentration: Filter the combined liquid with a 100-mesh sieve, pour into a stainless steel sandwich pot, boil over high heat, then turn to medium heat for open evaporation, and concentrate until the volume of the liquid is 1 / 3 of the original volume; Honey refining: Heat the honey to 116-118℃ (stringy state) in another pot, add rock sugar and boil until it turns amber, then mix with the concentrated liquid medicine; Simmer the paste: Keep the temperature in the pot at 90-95℃, stir clockwise with a copper spoon until the paste is in the shape of a "hanging flag"; (4) Filling When the paste temperature drops to 70-80℃, quickly put it into a sterilized brown glass bottle, cover the bottle mouth with food-grade PE film, tighten the bottle cap and turn it upside down for 30 minutes, use the residual heat to form a negative pressure seal, and store it in a cool place away from light.

3. The method for preparing the smart and beneficial wisdom cream according to claim 2, characterized in that: Soak angelica and astragalus in advance: spray the surface with rice wine before the first decoction and let it stand for 20 minutes to soften the fibrous tissue.

4. The method for preparing the smart and beneficial wisdom cream according to claim 2, characterized in that: During the third decoction, 0.5% citric acid solution (based on the amount of water) is added to promote the dissolution of mineral components.

5. The method for preparing the smart and beneficial wisdom cream according to claim 2, characterized in that: Gradient concentration technology is used during concentration: initial concentration stage (specific gravity 1.10-1.15): maintain steam pressure at 0.15MPa, and control evaporation rate at 2L / h; intermediate concentration stage (specific gravity 1.20-1.25): use a double-layer condensation reflux device to recover volatile components.

6. The method for preparing the smart and beneficial wisdom cream according to claim 2, characterized in that: The temperature of honey is controlled in stages during the refining process: 80℃ for melting honey → 100℃ for breaking crystals → 116-118℃ for drawing. The temperature difference in each stage does not exceed 2℃.

7. The method for preparing the smart and intelligent ointment according to claim 2, characterized in that: When collecting the paste, the stirring rate is linked to the paste viscosity: a step-by-step speed reduction from 60 rpm at the initial stage to 40 rpm in the middle stage and then to 20 rpm at the later stage.