Testing device and method for filter based on hemodialysis equipment

Abstract

The invention provides a test device and method for a filter based on hemodialysis equipment, and belongs to the technical field of medical instrument testing, the test device comprises a temperature adjusting assembly, a driving assembly, a detection unit and a control unit, the temperature adjusting assembly comprises a heating liquid storage barrel for heating a disinfectant and a cooling liquid storage barrel for cooling the disinfectant, the heating liquid storage barrel and the cooling liquid storage barrel are connected with the filter through a first circulating flow channel and a second circulating flow channel respectively, the driving assembly is used for driving a disinfectant to circularly flow in the first circulating flow channel and the second circulating flow channel, the detection unit is used for acquiring parameters of the first circulating flow channel and the second circulating flow channel in real time, and the control unit is used for controlling the disinfectant according to the parameters. And the temperature adjusting assembly and the driving assembly are controlled to adjust the disinfectant in the circulating flow channel to the target parameters. By simulating the environmental conditions of the hemodialysis machine during treatment and disinfection, the performance test with high automation degree is performed on the filter so as to judge the long-term stability of the filter.

Description

Technical Field

[0001] The present invention relates to the technical field of medical device testing, and in particular to a testing device and method for a filter based on a hemodialysis device. Background Art

[0002] As a key safety component of hemodialysis equipment, the endotoxin filter removes endotoxins, microorganisms and insoluble particles in the dialysate mainly through the retention effect of the filter membrane.

[0003] In order to obtain the service life of the endotoxin filter during actual use, it is generally necessary to test the performance of the endotoxin filter. Currently, the endotoxin filter is mainly installed on a hemodialysis machine for actual machine testing.

[0004] However, this method requires the use of expensive hemodialysis machines, and the detection process requires continuous consumption of special consumables such as dialysate and disinfectants. The initial detection investment cost is high. At the same time, manual intervention in the equipment operation status is required during the detection process, such as parameter adjustment, resulting in a large manpower investment. Summary of the invention

[0005] Based on this, the purpose of the present invention is to provide a testing device and method for a filter based on a hemodialysis device, which aims to perform a highly automated performance test on the endotoxin filter by simulating the environmental conditions during treatment and disinfection of the hemodialysis machine, so as to achieve the purpose of judging the long-term stability of the endotoxin filter.

[0006] To achieve the above objectives, in a first aspect, the present invention proposes a filter testing device based on a hemodialysis device for testing an endotoxin filter, comprising a temperature regulating component, a driving component, a detection unit, and a control unit. The temperature regulating component comprises a heating liquid storage barrel and a cooling liquid storage barrel for storing and regulating the temperature of the disinfectant, the heating liquid storage barrel and the cooling liquid storage barrel are connected to the endotoxin filter through a first circulation channel and a second circulation channel respectively, the heating liquid storage barrel is used to heat the disinfectant in the first circulation channel, and the cooling liquid storage barrel is used to cool the disinfectant in the second circulation channel; the driving component is connected to the first circulation channel and the second circulation channel, and is used to drive the disinfectant to circulate in the first circulation channel and the second circulation channel; the detection unit is used to obtain a first parameter of the disinfectant in the first circulation channel in real time, and to obtain a second parameter of the disinfectant in the second circulation channel in real time; the control unit is used to adjust the disinfectant in the first circulation channel to a first target parameter by controlling the heating liquid storage barrel and the driving component according to the first parameter, and the control unit is also used to adjust the disinfectant in the second circulation channel to a second target parameter by controlling the cooling liquid storage barrel and the driving component according to the second parameter; wherein the first parameter, the first target parameter, the second parameter, and the second target parameter all include the temperature of the disinfectant, the pressure of the disinfectant, and the flow rate of the disinfectant.

[0007] In addition, the filter testing device based on the hemodialysis device according to the present invention may also have the following additional technical features: Furthermore, the heating liquid storage barrel is provided with a first water inlet and a first water outlet, a first branch pipe that can be opened and closed is provided between the first water outlet and the input end of the driving component, a second branch pipe is provided between the output end of the driving component and the input end of the endotoxin filter, and a third branch pipe that can be opened and closed is provided between the output end of the endotoxin filter and the first water inlet.

[0008] Furthermore, the cooling liquid storage barrel is provided with a second water inlet and a second water outlet, a fourth branch pipe that can be opened and closed is provided between the second water outlet and the input end of the driving component, and a fifth branch pipe that can be opened and closed is provided between the output end of the endotoxin filter and the second water inlet.

[0009] Furthermore, the testing device for the filter based on the hemodialysis equipment also includes a flushing component, which is used to deliver cleaning agent to the endotoxin filter through the cleaning flow channel, and the detection unit is also used to obtain a third parameter of the cleaning agent in the cleaning flow channel in real time, and the control unit is also used to adjust the cleaning agent in the circulation flow channel to a third target parameter by controlling the driving component according to the third parameter, wherein the third parameter and the third target parameter both include the flow rate of the cleaning agent and the pressure of the cleaning agent.

[0010] Furthermore, the flushing component includes a sixth branch pipe that can be opened and closed, and a seventh branch pipe that can be opened and closed. The output end of the sixth branch pipe is connected to the input end of the driving component, and the input end of the sixth branch pipe is used for continuously inputting the cleaning agent. The input end of the seventh branch pipe is connected to the output end of the endotoxin filter, and the output end of the seventh branch pipe is used for continuously outputting the cleaning agent.

[0011] In a second aspect, the present invention further proposes a test method for a filter based on a hemodialysis device, which is implemented by the aforementioned test device for the filter based on the hemodialysis device, comprising an accelerated aging test step and a cooling test step, wherein the accelerated aging test step and the cooling test step are alternately performed for a set time; The accelerated aging test steps specifically include: Acquire a first parameter of the disinfectant in the first circulation flow channel in real time through the detection unit; The control unit adjusts the disinfectant in the first circulation flow channel to a first target parameter by controlling the heating liquid storage barrel and the driving assembly according to the first parameter, and the adjustment lasts for a first preset time; Wherein, the first parameter and the first target parameter both include the temperature of the disinfectant, the pressure of the disinfectant, and the flow rate of the disinfectant; The cooling test step specifically includes: Acquiring in real time through the detection unit a second parameter of the disinfectant in the second circulation flow channel; The control unit adjusts the disinfectant in the second circulation flow channel to a second target parameter by controlling the cooling liquid storage barrel and the driving assembly according to the second parameter, and the adjustment lasts for a second preset time; Wherein, the second parameter and the second target parameter both include the temperature of the disinfectant, the pressure of the disinfectant, and the flow rate of the disinfectant; During the process of alternating the accelerated aging test step and the cooling test step for a set time, when the detection unit detects that the pressure of the disinfectant and / or the flow rate of the disinfectant do not meet the preset conditions, the test is stopped.

[0012] Further, the disinfectant used in the accelerated aging test step is selected from citric acid or glycolic acid, and the mass concentration of citric acid and glycolic acid is 0.8%. The step of adjusting the disinfectant in the first circulation channel to the first target parameter by controlling the heated liquid storage barrel and the drive component and continuing for a first preset time specifically includes: the control unit controls the heated liquid storage barrel to heat the citric acid or glycolic acid to 80°C to 95°C, the control unit controls the drive component to inject the citric acid or glycolic acid into the first circulation channel at a flow rate of 600mL / min to 700mL / min and a pressure of 0.10MPa to 0.11MPa, and the citric acid or glycolic acid continues to flow in the first circulation channel for 60min; Alternatively, the disinfectant used in the accelerated aging test step is selected from sodium hypochlorite or peracetic acid, and the mass concentration of sodium hypochlorite and peracetic acid is 0.1%. The step of adjusting the disinfectant in the first circulation flow channel to the first target parameter by controlling the heated liquid storage barrel and the drive component and continuing for a first preset time specifically includes: the control unit controls the heated liquid storage barrel to heat the sodium hypochlorite or peracetic acid to 36.8°C to 37.2°C, the control unit controls the drive component to inject sodium hypochlorite or peracetic acid into the first circulation flow channel at a flow rate of 600mL / min to 700mL / min and a pressure of 0.10MPa to 0.11MPa, and the sodium hypochlorite or peracetic acid continues to flow in the first circulation flow channel for 60min.

[0013] Furthermore, the disinfectant used in the cooling test step is selected from citric acid, and the mass concentration of citric acid is 0.8%. The step of adjusting the disinfectant in the second circulation channel to the second target parameter by controlling the cooling liquid storage barrel and the driving component and continuing for a second preset time specifically includes: the control unit controls the cooling liquid storage barrel to cool the citric acid to 22°C ~ 26°C, the control unit controls the driving component to inject citric acid into the second circulation channel at a flow rate of 600mL / min ~ 700mL / min and a pressure of 0.10MPa ~ 0.11MPa, and the citric acid continues to flow in the second circulation channel for 10 minutes.

[0014] Furthermore, the testing device further comprises a flushing component, which is used to deliver a cleaning agent to the endotoxin filter through a cleaning flow channel. After the accelerated aging test step and the cooling test step are alternately performed, the testing method further comprises a flushing step, which comprises: Acquiring a third parameter of the cleaning agent in the cleaning flow channel in real time through the detection unit; The control unit adjusts the cleaning agent in the cleaning channel to a third target parameter by controlling the driving component according to the third parameter, and the adjustment lasts for a third preset time; Wherein, the third parameter and the third target parameter both include the flow rate of the cleaning agent and the pressure of the cleaning agent.

[0015] Furthermore, the cleaning agent used in the flushing step is selected from purified water, and the step of adjusting the cleaning agent in the cleaning channel to a third target parameter by controlling the driving component specifically includes: the control unit controls the driving component to inject purified water into the cleaning channel at a flow rate of 600mL / min to 700mL / min and a pressure of 0.10MPa to 0.11MPa.

[0016] The beneficial effects of the present invention include at least: constructing a circulation channel through non-hemodialysis machine equipment, and adjusting the driving components through the control unit to accurately control the operating environment in the circulation channel, so as to highly simulate the internal conditions of the hemodialysis equipment during treatment and disinfection, such as temperature, pressure, flow, etc., and can efficiently verify the expected service life of the endotoxin filter on the hemodialysis equipment. In addition, the disinfectants used in the aging acceleration step and the cooling step are recycled and consumed less, which reduces the detection investment cost compared with the existing technology; in addition, the entire accelerated aging and cooling process is completely automatically controlled by the control unit without human intervention, the detection efficiency is high, and the manpower investment cost is reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a structural schematic diagram of a first viewing angle of a testing device for a filter based on a hemodialysis device in an embodiment of the present invention; Figure 2 is a schematic structural diagram from a second viewing angle of a test device for a filter based on a hemodialysis device in an embodiment of the present invention; Figure 3 is a flow chart of a method for testing a filter based on a hemodialysis device in an embodiment of the present invention; Description of main component symbols: Heating liquid storage barrel 110, first water inlet 111, first water outlet 112, first branch pipe 113, first switch valve 114, second branch pipe 115, third branch pipe 116, second switch valve 117, damper 118, cooling liquid storage barrel 120, second water inlet 121, second water outlet 122, fourth branch pipe 123, third switch valve 124, fifth branch pipe 125, fourth switch valve 126, drive assembly 200, temperature sensor 310, pressure sensor 320, endotoxin filter 400, sixth branch pipe 510, seventh branch pipe 520, fifth switch valve 530, sixth switch valve 540, pressure reducing valve 550, eighth branch pipe 600, seventh switch valve 610; The following specific implementation manner will further illustrate the present invention in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0018] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. Several embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0019] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0020] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which the present invention belongs. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0021] Please refer to Figure 1 to Figure 2, a test device for a filter based on a hemodialysis device provided by the present invention, used for testing an endotoxin filter 400, the test device comprises a temperature adjustment component, a drive component 200, a detection unit, and a control unit, the temperature adjustment component comprises a heating liquid storage barrel 110 and a cooling liquid storage barrel 120 for storing and adjusting the temperature of a disinfectant. The storage chamber of the heating liquid storage barrel 110 stores a disinfectant, which is selected from citric acid, glycolic acid, sodium hypochlorite or peracetic acid, the storage chamber of the heating liquid storage barrel 110 is connected with an inlet and an outlet, and the inlet and outlet are connected by a pipeline to form a first circulation channel, the heating liquid storage barrel 110 is used to heat the disinfectant in the first circulation channel, and the endotoxin filter 400 is connected in series in the first circulation channel. The storage chamber of the cooling liquid storage barrel 120 stores a disinfectant, which is selected from citric acid. The storage chamber of the cooling liquid storage barrel 120 is connected to an inlet and an outlet, which are connected by a pipeline to form a second circulation channel. The cooling liquid storage barrel 120 is used to cool the disinfectant in the second circulation channel, and the endotoxin filter 400 is also connected in series in the second circulation channel. The driving component 200 is connected to the first circulation channel and the second circulation channel, and is used to drive the disinfectant to circulate in the first circulation channel and the second circulation channel. The detection unit is used to obtain the first parameter of the disinfectant in the first circulation channel in real time, and to obtain the second parameter of the disinfectant in the second circulation channel in real time.

[0022] During the test, the endotoxin filter 400 is first subjected to an accelerated aging test. Specifically, the control unit adjusts the disinfectant in the first circulation channel to the first target parameter by controlling the heating liquid storage barrel 110 and the driving assembly 200 according to the first parameter; then the endotoxin filter 400 is subjected to a cooling test. Specifically, the control unit adjusts the disinfectant in the second circulation channel to the second target parameter by controlling the cooling liquid storage barrel 120 and the driving assembly 200 according to the second parameter; then the accelerated aging test and the cooling test are performed alternately, and the test is stopped after the set time. Among them, the first parameter, the first target parameter, the second parameter, and the second target parameter all include the temperature of the disinfectant, the pressure of the disinfectant, and the flow rate of the disinfectant.

[0023] During the accelerated aging test and the cooling test, when the pressure of the disinfectant and / or the flow rate of the disinfectant does not meet the preset conditions as detected by the detection unit, the test is stopped. Exemplarily, when the detection unit detects that the pressure of the disinfectant in the first circulation channel or the second circulation channel changes and the pressure of the disinfectant is less than the preset pressure, the control unit controls the driving assembly 200 to stop inputting the disinfectant into the endotoxin filter 400.

[0024] In some optional embodiments, multiple endotoxin filters 400 may be provided, and the multiple endotoxin filters 400 are cascaded together and connected in series in the first circulation channel and the second circulation channel, so that the endotoxin filters 400 can be tested in batches to improve the testing efficiency.

[0025] In some optional embodiments, the drive assembly 200 includes a diaphragm metering pump, which can achieve high-precision metering, ensure that the disinfectant in the first circulation flow channel and the second circulation flow channel flows stably at the flow rate and pressure required by the test quality, and improve the test accuracy.

[0026] In some optional embodiments, such as Figure 1 , Figure 2 As shown, the heating liquid storage barrel 110 is provided with a first water inlet 111 and a first water outlet 112, a first branch pipe 113 is provided between the first water outlet 112 and the input end of the diaphragm metering pump, a first switch valve 114 is provided on the first branch pipe 113, the first switch valve 114 is electrically connected to the control unit, and the control unit can control the on-off of the first branch pipe 113, a second branch pipe 115 is provided between the output end of the diaphragm metering pump and the input end of the endotoxin filter 400, a third branch pipe 116 is provided between the output end of the endotoxin filter 400 and the first water inlet 111, a second switch valve 117 is provided on the third branch pipe 116, the second switch valve 117 is electrically connected to the control unit, and the control unit can control the on-off of the third branch pipe 116. Optionally, the first switch valve 114 and the second switch valve 117 can be electromagnetic valves.

[0027] In this embodiment, the heated liquid storage barrel 110, the first branch pipe 113, the diaphragm metering pump, the second branch pipe 115, the endotoxin filter 400 and the third branch pipe 116 constitute a first circulation channel, and the endotoxin filter 400 is subjected to an accelerated aging test by circulating a disinfectant heated to a preset temperature in the first circulation channel.

[0028] In some optional embodiments, such as Figure 1 , Figure 2 As shown, the cooling liquid storage barrel 120 is provided with a second water inlet 121 and a second water outlet 122, a fourth branch pipe 123 is provided between the second water outlet 122 and the input end of the diaphragm metering pump, a third switch valve 124 is provided on the fourth branch pipe 123, the third switch valve 124 is electrically connected to the control unit, and the control unit can control the on-off of the fourth branch pipe 123, a fifth branch pipe 125 is provided between the output end of the endotoxin filter 400 and the second water inlet 121, a fourth switch valve 126 is provided on the fifth branch pipe 125, the fourth switch valve 126 is electrically connected to the control unit, and the control unit can control the on-off of the fifth branch pipe 125. Optionally, the third switch valve 124 and the fourth switch valve 126 can be electromagnetic valves.

[0029] In this embodiment, the cooling liquid storage barrel 120, the fourth branch pipe 123, the diaphragm metering pump, the second branch pipe 115, the endotoxin filter 400 and the fifth branch pipe 125 form a second circulation channel, and the disinfectant cooled to a preset temperature is circulated in the second circulation channel to perform a cooling test on the endotoxin filter 400. Since the first circulation channel and the second circulation channel share the flow channel of the diaphragm metering pump, the second branch pipe 115, and the cascade part of the endotoxin filter 400, when switching between the accelerated aging test and the cooling test operation, there is no need to reconnect the pipeline of the endotoxin filter 400, and only the first switch valve 114, the second switch valve 117, the third switch valve 124, and the fourth switch valve 126 need to be controlled to be on and off, so that no manual intervention is required to achieve automatic switching. Specifically, when the accelerated aging test is first performed, the control unit controls the first switch valve 114 and the second switch valve 117 to open, and controls the third switch valve 124 and the fourth switch valve 126 to close; when the cooling test is performed afterwards, the control unit controls the first switch valve 114 and the second switch valve 117 to close, and controls the third switch valve 124 and the fourth switch valve 126 to open.

[0030] In some optional embodiments, the testing device further comprises a flushing component to flush the residual disinfectant in the endotoxin filter 400. Specifically, the flushing component is connected to the endotoxin filter 400 through a cleaning flow channel to deliver a cleaning agent to the endotoxin filter 400. Preferably, the cleaning agent is selected from purified water.

[0031] When cleaning the endotoxin filter 400, the third parameter of the cleaning agent in the cleaning flow channel is obtained in real time through the detection unit, wherein the third parameter includes the flow rate of the cleaning agent and the pressure of the cleaning agent. The control unit adjusts the cleaning agent in the cleaning flow channel to the third target parameter by controlling the driving component 200 according to the third parameter, and continues for a third preset time. The third parameter and the third target parameter both include the flow rate of the cleaning agent and the pressure of the cleaning agent, and the third preset time can be selected according to an empirical value.

[0032] In some optional embodiments, such as Figure 1 , Figure 2 As shown, the flushing assembly includes a sixth branch pipe 510 and a seventh branch pipe 520. The output end of the sixth branch pipe 510 is connected to the input end of the diaphragm metering pump, and the sixth branch pipe 510 is provided with a fifth switch valve 530, which is electrically connected to the control unit, and the control unit can control the opening and closing of the sixth branch pipe 510. The input end of the seventh branch pipe 520 is connected to the output end of the endotoxin filter 400, and the seventh branch pipe 520 is provided with a sixth switch valve 540, which is electrically connected to the control unit, and the control unit can control the opening and closing of the seventh branch pipe 520. Optionally, the fifth switch valve 530 and the sixth switch valve 540 can be electromagnetic valves.

[0033] In this embodiment, the sixth branch pipe 510, the diaphragm metering pump, the second branch pipe 115, the endotoxin filter 400 and the seventh branch pipe 520 form a cleaning flow channel, and the residual disinfectant in the endotoxin filter 400 is cleaned by injecting a cleaning agent into the cleaning flow channel. Specifically, during cleaning, a clean cleaning agent is continuously input into the input end of the sixth branch pipe 510, and the output end of the seventh branch pipe 520 continuously discharges the cleaning agent carrying the residual disinfectant. Since the first circulation flow channel, the second circulation flow channel, and the cleaning flow channel share the flow channel of the diaphragm metering pump, the second branch pipe 115, and the cascade part of the endotoxin filter 400, when switching the cooling test operation and the cleaning operation, there is no need to reconnect the pipeline of the endotoxin filter 400, and it is only necessary to control the on-off of the first switch valve 114, the second switch valve 117, the third switch valve 124, the fourth switch valve 126, the fifth switch valve 530 and the sixth switch valve 540, so that no manual intervention is required to achieve automatic switching. Specifically, when the accelerated aging test is first performed, the control unit controls the first switch valve 114 and the second switch valve 117 to open, and controls the third switch valve 124, the fourth switch valve 126, the fifth switch valve 530 and the sixth switch valve 540 to close; when the cooling test is performed afterwards, the control unit controls the first switch valve 114, the second switch valve 117, the fifth switch valve 530 and the sixth switch valve 540 to close, and controls the third switch valve 124 and the fourth switch valve 126 to open; after the accelerated aging test and the cooling test are alternately performed for a set time, the control unit controls the first switch valve 114, the second switch valve 117, the third switch valve 124 and the fourth switch valve 126 to close, and controls the fifth switch valve 530 and the sixth switch valve 540 to open.

[0034] In some optional embodiments, such as Figure 1 , Figure 2 As shown, a damper 118 is provided on the second branch pipe 115 at the output end of the diaphragm metering pump. The damper 118 attenuates the periodic pressure fluctuations generated during the operation of the diaphragm metering pump to a safe range through the synergistic effect of hydraulic buffering and gas compensation, thereby eliminating the water hammer effect and reducing the risk of resonance in the pipeline, thereby ensuring the pressure stability of the system under precision metering conditions.

[0035] In some optional embodiments, such as Figure 1 , Figure 2 As shown, a pressure reducing valve 550 is provided at the input end of the sixth branch pipe 510, and the pressure reducing valve 550 can reduce the pressure of the input cleaning agent, that is, the high-pressure cleaning agent is not directly injected into the cleaning flow channel, so as to avoid damage to parts including the endotoxin filter 400 due to pressure shock.

[0036] In some optional embodiments, the detection unit includes a temperature sensor 310, a pressure sensor 320 connected to the first circulation flow channel, the second circulation flow channel and the cleaning flow channel, and a concentration detection device for detecting the concentration of the disinfectant flowing in the first circulation flow channel and the second circulation flow channel. In order to reduce costs, the temperature sensor 310, the pressure sensor 320 and the concentration detection device can be arranged on the flow channel shared by the first circulation flow channel and the second circulation flow channel, that is, on the flow channel of the diaphragm metering pump, the second branch pipe 115, and the endotoxin filter 400 cascade.

[0037] In some optional embodiments, such as Figure 1 , Figure 2 As shown, an eighth branch pipe 600 is connected in parallel to the flow channel shared by the first circulation flow channel and the second circulation flow channel, and a seventh switch valve 610 is provided on the eighth branch pipe 600. The seventh switch valve 610 is electrically connected to the control unit, and the control unit can control the on-off of the eighth branch pipe 600. The output end of the eighth branch pipe 600 is connected to the concentration detection device. In this embodiment, the control unit controls the on-off of the seventh switch valve 610, and the concentration detection device can sample and detect the disinfectant at a preset interval time, so as to determine whether the concentration of the disinfectant meets the test requirements.

[0038] Please refer to Figure 3 , a test method for a filter based on a hemodialysis device provided by the present invention is used to be implemented by the aforementioned test device for the filter based on the hemodialysis device, and the test method includes an accelerated aging test step S100 and a cooling test step S200, and the accelerated aging test step S100 and the cooling test step S200 are alternately performed for a set time.

[0039] Step S100, the accelerated aging test step specifically includes: Acquire a first parameter of the disinfectant in the first circulation flow channel in real time through a detection unit; The control unit adjusts the disinfectant in the first circulation flow channel to the first target parameter by controlling the heating liquid storage barrel 110 and the driving assembly 200 according to the first parameter, and lasts for a first preset time; Wherein, the first parameter and the first target parameter both include the temperature of the disinfectant, the pressure of the disinfectant, and the flow rate of the disinfectant; Step S200, cooling test step specifically includes: Acquire a second parameter of the disinfectant in the second circulation flow channel in real time through a detection unit; The control unit adjusts the disinfectant in the second circulation flow channel to a second target parameter according to the second parameter by controlling the cooling liquid storage barrel 120 and the driving assembly 200, and the second target parameter is maintained for a second preset time. Wherein, the second parameter and the second target parameter both include the temperature of the disinfectant, the pressure of the disinfectant, and the flow rate of the disinfectant; During the process of the accelerated aging test step S100 and the cooling test step S200 being performed alternately for a set time, when the detection unit detects that the pressure of the disinfectant and / or the flow rate of the disinfectant do not meet the preset conditions, the test is stopped.

[0040] Exemplarily, when the detection unit detects that the pressure of the disinfectant in the first circulation channel or the second circulation channel changes and the pressure of the disinfectant is less than a preset pressure, the control unit controls the driving assembly 200 to stop inputting the disinfectant into the endotoxin filter 400 .

[0041] In some optional embodiments, the disinfectant used in the accelerated aging test step S100 is selected from citric acid or glycolic acid, and the mass concentration of citric acid and glycolic acid is 0.8%. The steps of adjusting the disinfectant in the first circulation flow channel to the first target parameter by controlling the heating liquid storage barrel 110 and the driving component 200 and continuing the first preset time specifically include: The control unit controls the heating liquid storage tank 110 to heat the citric acid or glycolic acid to 80° C. to 95° C.; The control unit controls the driving component 200 to inject citric acid or glycolic acid into the first circulation channel at a flow rate of 600 mL / min to 700 mL / min and a pressure of 0.10 MPa to 0.11 MPa. The citric acid or glycolic acid continues to flow in the first circulation channel for 60 minutes.

[0042] In some optional embodiments, the disinfectant used in the accelerated aging test step S100 is selected from sodium hypochlorite or peracetic acid, and the mass concentration of sodium hypochlorite and peracetic acid is 0.1%. The steps of adjusting the disinfectant in the first circulation flow channel to the first target parameter by controlling the heating liquid storage barrel 110 and the driving component 200 and continuing the first preset time specifically include: The control unit controls the heating liquid storage tank 110 to heat the sodium hypochlorite or peracetic acid to 36.8° C. to 37.2° C.; The control unit controls the driving component 200 to inject sodium hypochlorite or peracetic acid into the first circulation channel at a flow rate of 600 mL / min to 700 mL / min and a pressure of 0.10 MPa to 0.11 MPa, and the sodium hypochlorite or peracetic acid continues to flow in the first circulation channel for 60 minutes.

[0043] In some optional embodiments, the disinfectant used in the cooling test step S200 is selected from citric acid, and the mass concentration of the citric acid is 0.8%. The step of adjusting the disinfectant in the second circulation flow channel to the second target parameter by controlling the cooling liquid storage barrel 120 and the driving component 200 and continuing the second preset time specifically includes: The control unit controls the cooling liquid storage tank 120 to cool the citric acid to 22° C. to 26° C.; The control unit controls the driving assembly 200 to inject citric acid into the second circulation channel at a flow rate of 600 mL / min to 700 mL / min and a pressure of 0.10 MPa to 0.11 MPa. The citric acid continues to flow in the second circulation channel for 10 minutes.

[0044] In some optional embodiments, the accelerated aging test step S100 and the cooling test step S200 are alternately performed for 175 hours.

[0045] In some optional embodiments, the testing device further includes a flushing component, which is used to deliver a cleaning agent to the endotoxin filter through a cleaning flow channel. After the accelerated aging test step S100 and the cooling test step S200 are alternately performed, the testing method further includes a flushing step S300; The flushing step S300 specifically includes: Acquiring a third parameter of the cleaning agent in the cleaning flow channel in real time through the detection unit; The control unit adjusts the cleaning agent in the cleaning channel to a third target parameter by controlling the driving assembly 200 according to the third parameter, and keeps the parameter for a third preset time; The third parameter and the third target parameter both include the flow rate of the cleaning agent and the pressure of the cleaning agent, and the third preset time can be selected according to empirical values.

[0046] In some optional embodiments, the cleaning agent used in the flushing step S300 is selected from purified water, and the step of adjusting the cleaning agent in the cleaning flow channel to the third target parameter by controlling the driving component 200 specifically includes: The control unit controls the driving component to inject purified water into the cleaning flow channel at a flow rate of 600mL / min to 700mL / min and a pressure of 0.10MPa to 0.11MPa.

[0047] In some optional embodiments, the control unit may be implemented using any one or a combination of the following technologies known in the art, such as a discrete logic circuit having a logic gate circuit for implementing logic functions on data signals, a dedicated integrated circuit having a suitable combinational logic gate circuit, a programmable gate array (PGA), a field programmable gate array (FPGA), etc. In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0048] The above-mentioned embodiments only express several implementation modes of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the protection scope of the present invention. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the attached claims.

Claims

1. A test device for a filter based on a hemodialysis device, characterized in that: Used to test an endotoxin filter, the testing device comprises: A temperature regulating component, comprising a heating liquid storage barrel and a cooling liquid storage barrel for storing and regulating the temperature of a disinfectant, wherein the heating liquid storage barrel and the cooling liquid storage barrel are connected to an endotoxin filter through a first circulation channel and a second circulation channel, respectively, wherein the heating liquid storage barrel is used to heat the disinfectant in the first circulation channel, and the cooling liquid storage barrel is used to cool the disinfectant in the second circulation channel; A driving component, connected to the first circulation flow channel and the second circulation flow channel, and used to drive the disinfectant to circulate in the first circulation flow channel and the second circulation flow channel; a detection unit, configured to obtain in real time a first parameter of the disinfectant in the first circulation flow channel, and to obtain in real time a second parameter of the disinfectant in the second circulation flow channel; a control unit, configured to adjust the disinfectant in the first circulation flow channel to a first target parameter by controlling the heating liquid storage barrel and the driving assembly according to the first parameter, and further configured to adjust the disinfectant in the second circulation flow channel to a second target parameter by controlling the cooling liquid storage barrel and the driving assembly according to the second parameter; The first parameter, the first target parameter, the second parameter and the second target parameter all include the temperature of the disinfectant, the pressure of the disinfectant and the flow rate of the disinfectant.

2. The filter testing device based on the hemodialysis equipment according to claim 1, characterized in that: The heating liquid storage barrel is provided with a first water inlet and a first water outlet, a first branch pipe that can be opened and closed is provided between the first water outlet and the input end of the driving component, a second branch pipe is provided between the output end of the driving component and the input end of the endotoxin filter, and a third branch pipe that can be opened and closed is provided between the output end of the endotoxin filter and the first water inlet.

3. The filter testing device based on the hemodialysis equipment according to claim 2, characterized in that: The cooling liquid storage barrel is provided with a second water inlet and a second water outlet, a fourth branch pipe that can be opened and closed is provided between the second water outlet and the input end of the driving component, and a fifth branch pipe that can be opened and closed is provided between the output end of the endotoxin filter and the second water inlet.

4. The filter testing device based on the hemodialysis equipment according to claim 2, characterized in that: The filter testing device based on the hemodialysis equipment also includes a flushing component, which is used to transport cleaning agent to the endotoxin filter through the cleaning flow channel. The detection unit is also used to obtain a third parameter of the cleaning agent in the cleaning flow channel in real time. The control unit is also used to adjust the cleaning agent in the circulation flow channel to a third target parameter by controlling the driving component according to the third parameter, wherein the third parameter and the third target parameter both include the flow rate of the cleaning agent and the pressure of the cleaning agent.

5. The filter testing device based on the hemodialysis equipment according to claim 4, characterized in that: The flushing assembly comprises: an openable and closable sixth branch pipe, the output end of the sixth branch pipe being connected to the input end of the driving assembly, and the input end of the sixth branch pipe being used for continuously inputting cleaning agent; The seventh branch pipe can be opened and closed, the input end of the seventh branch pipe is connected to the output end of the endotoxin filter, and the output end of the seventh branch pipe is used for continuously outputting the cleaning agent.

6. A method for testing a filter based on a hemodialysis device, characterized in that: Used to be implemented by a test device based on a filter of a hemodialysis device as claimed in any one of claims 1 to 3, comprising an accelerated aging test step and a cooling test step, wherein the accelerated aging test step and the cooling test step are alternately performed for a set time; The accelerated aging test steps specifically include: Acquire a first parameter of the disinfectant in the first circulation flow channel in real time through the detection unit; The control unit adjusts the disinfectant in the first circulation flow channel to a first target parameter by controlling the heating liquid storage barrel and the driving assembly according to the first parameter, and the adjustment lasts for a first preset time; Wherein, the first parameter and the first target parameter both include the temperature of the disinfectant, the pressure of the disinfectant, and the flow rate of the disinfectant; The cooling test step specifically includes: Acquiring in real time through the detection unit a second parameter of the disinfectant in the second circulation flow channel; The control unit adjusts the disinfectant in the second circulation flow channel to a second target parameter by controlling the cooling liquid storage barrel and the driving assembly according to the second parameter, and the adjustment lasts for a second preset time; Wherein, the second parameter and the second target parameter both include the temperature of the disinfectant, the pressure of the disinfectant, and the flow rate of the disinfectant; During the process of alternating the accelerated aging test step and the cooling test step for a set time, when the detection unit detects that the pressure of the disinfectant and / or the flow rate of the disinfectant do not meet the preset conditions, the test is stopped.

7. The method for testing a filter based on a hemodialysis device according to claim 6, characterized in that: The disinfectant used in the accelerated aging test step is selected from citric acid or glycolic acid, and the mass concentration of citric acid and glycolic acid is 0.8%. The step of adjusting the disinfectant in the first circulation channel to the first target parameter by controlling the heated liquid storage barrel and the drive component and continuing for a first preset time specifically includes: the control unit controls the heated liquid storage barrel to heat the citric acid or glycolic acid to 80°C to 95°C, the control unit controls the drive component to inject citric acid or glycolic acid into the first circulation channel at a flow rate of 600mL / min to 700mL / min and a pressure of 0.10MPa to 0.11MPa, and the citric acid or glycolic acid flows continuously in the first circulation channel for 60min; Alternatively, the disinfectant used in the accelerated aging test step is selected from sodium hypochlorite or peracetic acid, and the mass concentration of sodium hypochlorite and peracetic acid is 0.1%. The step of adjusting the disinfectant in the first circulation flow channel to the first target parameter by controlling the heated liquid storage barrel and the drive component and continuing for a first preset time specifically includes: the control unit controls the heated liquid storage barrel to heat the sodium hypochlorite or peracetic acid to 36.8°C to 37.2°C, the control unit controls the drive component to inject sodium hypochlorite or peracetic acid into the first circulation flow channel at a flow rate of 600mL / min to 700mL / min and a pressure of 0.10MPa to 0.11MPa, and the sodium hypochlorite or peracetic acid continues to flow in the first circulation flow channel for 60min.

8. The method for testing a filter based on a hemodialysis device according to claim 6, characterized in that: The disinfectant used in the cooling test step is selected from citric acid, and the mass concentration of citric acid is 0.8%. The step of adjusting the disinfectant in the second circulation channel to the second target parameter by controlling the cooling liquid storage barrel and the driving component and continuing for a second preset time specifically includes: the control unit controls the cooling liquid storage barrel to cool the citric acid to 22°C ~ 26°C, the control unit controls the driving component to inject citric acid into the second circulation channel at a flow rate of 600mL / min ~ 700mL / min and a pressure of 0.10MPa ~ 0.11MPa, and the citric acid continues to flow in the second circulation channel for 10 minutes.

9. The method for testing a filter based on a hemodialysis device according to any one of claims 6 to 8, characterized in that: The testing device further includes a flushing component, which is used to deliver a cleaning agent to the endotoxin filter through a cleaning flow channel. After the accelerated aging test step and the cooling test step are alternately performed, the testing method further includes a flushing step, which specifically includes: Acquiring a third parameter of the cleaning agent in the cleaning flow channel in real time through the detection unit; The control unit adjusts the cleaning agent in the cleaning channel to a third target parameter by controlling the driving component according to the third parameter, and the adjustment lasts for a third preset time; Wherein, the third parameter and the third target parameter both include the flow rate of the cleaning agent and the pressure of the cleaning agent.

10. The method for testing a filter based on a hemodialysis device according to claim 9, characterized in that: The cleaning agent used in the flushing step is selected from purified water, and the step of adjusting the cleaning agent in the cleaning channel to the third target parameter by controlling the driving component specifically includes: the control unit controls the driving component to inject purified water into the cleaning channel at a flow rate of 600mL / min to 700mL / min and a pressure of 0.10MPa to 0.11MPa.

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