Magnetic nerve regulation and control experimental device for heat exercise and heat stroke research

Abstract

The invention provides a magnetic nerve regulation and control experimental device for heat habit and heat stroke research. The magnetic nerve regulation and control experimental device comprises a rack, an experimental cabin, a magnetic field generation mechanism and a driving mechanism. The experiment module is arranged on the rack, the magnetic field generation mechanism is arranged on the rack, and the magnetic field generation mechanism is used for generating a magnetic field in the experiment module. The driving mechanism is used for driving the magnetic field generation mechanism to rotate to realize magnetic field rotation. The magnetic field generating mechanism is driven by the driving mechanism to rotate, so that a rotating magnetic field is formed in the experiment module, the rotating magnetic field rotates at 180 degrees / s, neuronal regulation and control are realized in combination with the magnetic nanoparticles, and the body temperature of the experiment mouse is controlled. Compared with a two-photon optogenetics technology in the prior art, neuron noninvasive regulation and control can be achieved, the survival time of laboratory mice is long, the monitoring time is long, and large sample experiments can be conducted.

Description

Technical Field

[0001] The invention relates to the technical field of experimental equipment, and in particular to a magnetic nerve regulation experimental device for heat acclimatization and heat stroke research. Background Art

[0003] During the experimental research on heat acclimatization and heat stroke, experimental mice with controllable body temperature need to be placed in a special environmental chamber. The special environmental chamber can adjust parameters such as temperature, humidity, and oxygen content to simulate a hot environment, and then the experimental mice are monitored.

[0004] In experiments, two-photon optogenetics technology is often used. Through surgery, the cortical neurons of experimental mice can be quickly inhibited and activated to control their body temperature. However, this method is invasive, the survival time of experimental mice is short, and in large-sample experiments, surgery is performed on a large number of experimental mice, which is inefficient. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides a magnetic neural regulation experimental device for heat acclimatization and heat stroke research, thereby solving or at least alleviating one or more of the above-mentioned problems and other problems in the prior art.

[0006] The present invention provides a magnetic nerve regulation experimental device for heat acclimatization and heat stroke research, comprising:

[0007] frame;

[0008] An experimental cabin, arranged on the rack, for placing experimental mice;

[0009] a magnetic field generating mechanism, disposed on the frame, corresponding to the experimental chamber, and used to generate a magnetic field in the experimental chamber; and

[0010] The driving mechanism is used to drive the magnetic field generating mechanism to rotate.

[0011] Preferably, the experimental cabin comprises:

[0012] An annular enclosure plate can be kept stationary on the frame;

[0013] a clearance sleeve, located in the annular shroud and coaxial with the annular shroud; and

[0014] The bottom support assembly is located between the annular enclosure plate and the clearance sleeve, and forms an annular placement groove with the annular enclosure plate and the clearance sleeve.

[0015] Preferably, the magnetic field generating mechanism comprises:

[0016] A connecting frame, rotatably connected to the lower end of the yield sleeve;

[0017] A first magnetic mounting seat, connected to one end of the connecting frame, on which a plurality of magnets are mounted; and

[0018] A second magnetic mounting seat, connected to the other end of the connecting frame, opposite to the first magnetic mounting seat, and having a plurality of magnets mounted thereon;

[0019] The driving mechanism is used to drive the connecting frame to rotate; the annular enclosure is located between the first magnetic mounting seat and the second magnetic mounting seat; a magnetic field is formed between the magnet on the first magnetic mounting seat and the magnet on the second magnetic mounting seat.

[0020] Preferably, there are more than two experimental chambers arranged vertically; and the magnetic field generating mechanism is arranged corresponding to the experimental chambers.

[0021] Preferably, the annular enclosure plate is movable vertically;

[0022] The bottom support assembly comprises:

[0023] The first fan ring plate has an outer ring connected to the inner wall of the lower end of the annular enclosure plate, and an inner ring connected to the outer wall of the yield sleeve;

[0024] A first bearing, sleeved on the giving way sleeve and located below the first meniscus; and

[0025] A second fan ring plate, the inner ring of which is connected to the outer ring of the first bearing;

[0026] The second sector ring plate and the first sector ring plate can form a circular ring.

[0027] Preferably, the connecting frame comprises:

[0028] A connecting plate having a mounting hole formed thereon, wherein the connecting plate is rotatably connected to the lower end of the sleeve; and

[0029] Two connecting rods are provided, one end of each connecting rod is connected to the connecting plate, and the other end of each connecting rod is connected to the corresponding first magnetic mounting seat or the second magnetic mounting seat;

[0030] The driving mechanism comprises:

[0031] There are more than two drive sleeves, and the inner cavity cross section of the drive sleeve is square. The outer wall of the drive sleeve is connected to the inner wall of the mounting hole;

[0032] A first driving rod is arranged vertically, has a square cross section, and can be slidably matched with the inner wall of the driving sleeve vertically;

[0033] a second driving rod connected to the lower end of the first driving rod coaxially, the second driving rod being rotatably disposed on the frame, the cross section of the second driving rod being square and smaller than the cross section area of ​​the first driving rod; and

[0034] The motor is arranged on the frame, and its output end is connected to the lower end of the second driving rod. Preferably, the frame comprises a plurality of columns; a vertical guide groove is provided on the inner side of the columns; a plurality of limit grooves extending in the transverse direction are also provided on the inner side of the columns; the plurality of limit grooves are distributed vertically and are all connected to the guide groove;

[0035] A plurality of guide plates are connected to the outer wall of the annular enclosure; one end of the guide plate away from the annular enclosure is vertically slidably matched with the corresponding guide groove and can be laterally inserted into the corresponding limit groove.

[0036] Preferably, the bottom support assembly further comprises:

[0037] A first baffle is connected to one end of the first fan ring plate, and two ends of the first baffle are respectively connected to the inner wall of the annular enclosure plate and the outer wall of the sleeve;

[0038] Two limit blocks are provided, and are respectively connected to both sides of the end of the second fan ring plate, and the limit blocks can be close to the first baffle plate as the second fan ring plate rotates; and

[0039] The second baffle plate has sliding grooves at both ends, and the sliding grooves can be slidably matched with the corresponding limiting blocks along the vertical direction.

[0040] Preferably, the diameters of the annular shrouds are different.

[0041] Compared with the prior art, the present invention has the following beneficial effects:

[0042] In the technology of the present invention, the magnetic field generating mechanism is driven to rotate by the driving mechanism, thereby forming a rotating magnetic field in the experimental cabin. The rotating magnetic field rotates at 180° / s. Combined with magnetic nanoparticles, neuronal regulation is achieved to control the body temperature of experimental mice. Compared with the two-photon optogenetics technology in the prior art, non-invasive regulation of neurons can be achieved, experimental mice survive longer, can be monitored for a long time, and large sample experiments can be performed. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following is a brief introduction to the drawings required for the specific embodiments or the description of the prior art. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn according to the actual scale.

[0044] Figure 1 It is a stereoscopic diagram of a magnetic nerve regulation experimental device for heat acclimatization and heat stroke research in one embodiment of the present invention;

[0045] Figure 2 for Figure 1 Another stereogram of the experiment cabin (only one experimental cabin is retained);

[0046] Figure 3 for Figure 2 A three-dimensional diagram of the central experimental cabin and the magnetic field generating mechanism;

[0047] Figure 4 for Figure 3 AA surface section view;

[0048] Figure 5 for Figure 4 An enlarged schematic diagram of S;

[0049] Figure 6 for Figure 3 Explosion diagram of

[0050] Figure 7 for Figure 6 Another stereogram.

[0051] Reference numerals:

[0052] 10. Frame; 11. Column; 12. Guide groove; 13. Limiting groove;

[0053] 20. Experimental cabin; 21. Annular enclosure; 22. Displacement sleeve; 23. Bottom support assembly; 231. First fan ring plate; 232. First bearing; 233. Second fan ring plate; 234. First baffle plate; 235. Limit block; 236. Second baffle plate; 24. Guide plate;

[0054] 30. Magnetic field generating mechanism; 31. Connecting frame; 311. Connecting plate; 312. Connecting rod; 32. First magnetic mounting seat; 33. Second magnetic mounting seat;

[0055] 40. Driving mechanism; 41. Driving sleeve; 42. First driving rod; 43. Second driving rod; 44. Motor. DETAILED DESCRIPTION

[0056] The following embodiments of the technical solution of the present invention are described in detail in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present invention, and are therefore only used as examples, and cannot be used to limit the protection scope of the present invention.

[0057] It should be noted that, unless otherwise specified, the technical terms or scientific terms used in this application should have the common meanings understood by those skilled in the art to which the invention belongs.

[0058] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0059] In addition, the terms "first", "second", etc. are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. In the description of the present invention, the meaning of "plurality" is more than two, unless otherwise clearly and specifically defined.

[0060] In this application, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0061] In the present application, unless otherwise clearly specified and limited, a first feature being “above” or “below” a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being “above”, “above”, and “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below”, “below”, and “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0062] See also Figures 1 to 7 This embodiment provides a magnetic neural regulation experimental device for heat acclimatization and heat stroke research, including a frame 10, an experimental cabin 20, a magnetic field generating mechanism 30 and a driving mechanism 40.

[0063] The experimental chamber 20 is arranged on the frame 10, and the experimental chamber 20 is used to place the experimental mouse. The magnetic field generating mechanism 30 is arranged on the frame 10, and the magnetic field generating mechanism 30 corresponds to the experimental chamber 20, and the magnetic field generating mechanism 30 is used to generate a magnetic field in the experimental chamber 20. The driving mechanism 40 is used to drive the magnetic field generating mechanism 30 to rotate to realize the magnetic field rotation.

[0064] In this embodiment, m-Torquer is injected into the experimental mouse, which is a 200nm, spherical, single-layer octahedral magnetic nanoparticle. The particle can penetrate the blood-brain barrier, reach the targeted research neurons and mark them. Then the experimental mouse is placed in the experimental cabin 20, and the magnetic field generating mechanism 30 is driven to rotate by the driving mechanism 40, so as to form a rotating magnetic field in the experimental cabin 20. The rotating magnetic field rotates at 180° / s. Combined with magnetic nanoparticles, neuronal regulation is achieved, thereby controlling the body temperature of the experimental mouse. Compared with the two-photon optogenetics technology in the prior art, non-invasive regulation of neurons can be achieved, the experimental mouse has a long survival time, can be monitored for a long time, and can conduct large sample experiments.

[0065] In one embodiment, the experimental chamber 20 includes an annular enclosure 21 , a clearance sleeve 22 and a bottom support assembly 23 .

[0066] The annular enclosure 21 can be kept on the frame 10. The clearance sleeve 22 is located in the annular enclosure 21, and the clearance sleeve 22 is coaxial with the annular enclosure 21. The bottom support assembly 23 is located between the annular enclosure 21 and the clearance sleeve 22, and the bottom support assembly 23, the annular enclosure 21 and the clearance sleeve 22 form an annular placement groove, and the experimental mouse can be placed in the placement groove from above during the experiment.

[0067] In one embodiment, the magnetic field generating mechanism 30 includes a connecting frame 31 , a first magnetic mounting seat 32 and a second magnetic mounting seat 33 .

[0068] The connecting frame 31 is rotatably connected to the lower end of the yield sleeve 22. The first magnetic mounting seat 32 is connected to one end of the connecting frame 31, and a plurality of magnets are mounted thereon. The second magnetic mounting seat 33 is connected to the other end of the connecting frame 31, and the second magnetic mounting seat 33 is opposite to the first magnetic mounting seat 32, and a plurality of magnets are mounted thereon. The driving mechanism 40 is used to drive the connecting frame 31 to rotate; the annular enclosure 21 is located between the first magnetic mounting seat 32 and the second magnetic mounting seat 33; a magnetic field is formed between the magnet on the first magnetic mounting seat 32 and the magnet on the second magnetic mounting seat 33.

[0069] In this embodiment, the driving mechanism 40 drives the connecting frame 31 to rotate, thereby driving the first magnetic mounting seat 32 and the second magnetic mounting seat 33 to rotate, thereby generating a rotating magnetic field.

[0070] In one embodiment, more than two experimental chambers 20 are vertically arranged, and the magnetic field generating mechanism 30 is arranged corresponding to the experimental chambers 20. Arranging multiple experimental chambers 20 can cope with large sample experiments.

[0071] In one embodiment, the bottom support assembly 23 includes a first fan ring plate 231 , a first bearing 232 , and a second fan ring plate 233 .

[0072] The annular shroud 21 can move vertically.

[0073] The outer ring of the first fan ring plate 231 is connected to the inner wall of the lower end of the annular enclosure plate 21, and the inner ring of the first fan ring plate 231 is connected to the outer wall of the clearance sleeve 22. The first bearing 232 is sleeved on the clearance sleeve 22, and the first bearing 232 is located below the first meniscus. The inner ring of the second fan ring plate 233 is connected to the outer ring of the first bearing 232. The second fan ring plate 233 and the first fan ring plate 231 can form a circular ring.

[0074] In this embodiment, when a large sample experiment is required, the annular enclosure 21 is moved vertically downward, multiple experimental chambers 20 are stacked together, all the experimental mice are dumped into the topmost experimental chamber 20, and the second fan-shaped plate is manually pushed so that the space between the annular enclosure 21 and the first fan-shaped plate can form a channel, and the excess experimental mice fall from there, and then the second fan-shaped plate is rotated so that the second fan-shaped plate and the first fan-shaped plate form a complete circle, so that the experimental mice thereon cannot fall into the experimental chamber 20 below, and the subsequent experimental chambers 20 are operated in the same way, and the experimental mice grouping can be completed more efficiently.

[0075] In one embodiment, the connecting frame 31 includes a connecting plate 311 and a connecting rod 312 .

[0076] The connecting plate 311 is provided with a mounting hole, and the connecting plate 311 is rotatably connected to the lower end of the sleeve. Specifically, the connecting plate 311 is also provided with a second bearing, the outer ring of the second bearing is connected to the upper end of the connecting plate 311, and the inner ring of the second bearing is sleeved on the lower end of the yield sleeve 22. Two connecting rods 312 are provided, one end of the connecting rod 312 is connected to the connecting plate 311, and the other end of the connecting rod 312 is connected to the corresponding first magnetic mounting seat 32 or the second magnetic mounting seat 33.

[0077] The driving mechanism 40 includes a driving sleeve 41 , a first driving rod 42 , a second driving rod 43 and a motor 44 .

[0078] There are more than two drive sleeves 41, and the inner cavity cross section of the drive sleeve 41 is square. The outer wall of the drive sleeve 41 is connected to the inner wall of the mounting hole. The first drive rod 42 is vertically arranged, and its cross section is square, and can be slidably matched with the inner wall of the drive sleeve 41 along the vertical direction.

[0079] The second driving rod 43 is connected to the lower end of the first driving rod 42 on the same center line, and the second driving rod 43 is rotatably arranged on the frame 10. The cross section of the second driving rod 43 is square and smaller than the cross section area of ​​the first driving rod 42. The motor 44 is arranged on the frame 10, and the output end thereof is connected to the lower end of the second driving rod 43. The upper end of the second driving rod 43 and the lower end of the first driving rod 42 are transitioned through a square pyramid.

[0080] In this embodiment, the experimental chamber 20 can move up and down and drive the magnetic field generating mechanism to move up and down. Multiple experimental chambers 20 can move downward and stack. At this time, the drive sleeve 41 is located at the second drive rod 43. At this time, the motor 44 drives the second drive rod 43 to rotate, and the drive sleeve 41 does not rotate. When the experimental chamber 20 drives the connecting plate 311 to move upward, the drive sleeve 41 moves from the second drive rod 43 to the first drive rod 42. At this time, the rotation of the motor 44 can cause the drive sleeve 41 to rotate, thereby realizing the rotation of the magnetic field.

[0081] In one embodiment, the frame 10 includes a plurality of columns 11; a vertical guide groove 12 is formed inside the columns 11; a plurality of limit grooves 13 extending in the transverse direction are also formed inside the columns 11; the plurality of limit grooves 13 are distributed vertically and are all connected to the guide groove 12;

[0082] A plurality of guide plates 24 are connected to the outer wall of the annular enclosure 21 ; one end of the guide plate 24 away from the annular enclosure 21 is slidably matched with the corresponding guide groove 12 along the vertical direction, and can be inserted into the corresponding limit groove 13 laterally.

[0083] In this embodiment, the annular enclosure 21 is lifted to achieve the raising of the experimental chamber 20. At this time, the guide plate 24 slides upward in the corresponding guide groove 12, the paper guide plate 24 slides to the limit groove 13, and the annular enclosure 21 is rotated. The end of the guide plate 24 away from the annular enclosure 21 moves horizontally to the corresponding limit groove 13. At this time, the experimental chamber 20 remains there and does not move.

[0084] In one embodiment, the bottom support assembly 23 further includes a first baffle 234 , a limiting block 235 and a second baffle 236 .

[0085] The first baffle 234 is connected to one end of the first fan ring plate 231, and the two ends of the first baffle 234 are respectively connected to the inner wall of the annular enclosure 21 and the outer wall of the clearance sleeve 22; two limit blocks 235 are provided, and the two limit blocks 235 are respectively connected to the two sides of the end of the second fan ring plate 233, and the limit blocks 235 can be close to the first baffle 234 as the second fan ring plate 233 rotates. Sliding grooves are provided at both ends of the second baffle 236, and the sliding grooves can be matched with the corresponding limit blocks 235 in a vertical sliding direction.

[0086] In this embodiment, there is a passage between the first baffle plate 234 and the second baffle plate 236, through which the experimental mice can enter the experimental cabin 20 of the next layer. When the experimental cabins 20 are stacked, the second baffle plate 236 is removed, and the extra experimental mice are put into the experimental cabin 20 of the next layer through the passage between the second baffle plate 236 and the first baffle plate 234, and then the second baffle plate 236 is docked with the limit block 235, and the experimental mice of this layer move on the first fan-shaped plate and the second fan-shaped plate. The first baffle plate 234 can prevent the experimental mice from falling from there to the next layer.

[0087] In one embodiment, the diameters of the annular panels 21 are different. By changing the diameter of the annular panels 21, the distance between the magnets on both sides can be changed, thereby changing the magnetic field strength, thereby changing the intensity of the neural regulation received by the experimental mice.

[0088] In the description of the present invention, a large number of specific details are described. However, it is understood that embodiments of the present invention can be practiced without these specific details. In some instances, well-known methods, structures and techniques are not shown in detail so as not to obscure the understanding of this description.

[0089] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein by equivalents. These modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be included in the scope of the claims and specification of the present invention.

Claims

1. A magnetic neural regulation experimental device for heat acclimatization and heat stroke research, characterized in that: include: Frame (10); An experimental cabin (20), arranged on the rack (10) and used for placing experimental mice; A magnetic field generating mechanism (30) is arranged on the frame (10), corresponds to the experimental chamber (20), and is used to generate a magnetic field in the experimental chamber (20); as well as A driving mechanism (40) is used for driving the magnetic field generating mechanism (30) to rotate.

2. A magnetic neural regulation experimental device for heat acclimatization and heat stroke research as claimed in claim 1, characterized in that: The experimental chamber (20) comprises: An annular enclosure plate (21) can be kept stationary on the frame (10); a clearance sleeve (22), located inside the annular enclosure plate (21) and coaxial with the annular enclosure plate (21); and The bottom support assembly (23) is located between the annular enclosure plate (21) and the clearance sleeve (22), and forms an annular placement groove with the annular enclosure plate (21) and the clearance sleeve (22).

3. A magnetic neural regulation experimental device for heat acclimatization and heat stroke research as claimed in claim 2, characterized in that: The magnetic field generating mechanism (30) comprises: A connecting frame (31) is rotatably connected to the lower end of the yield sleeve (22); A first magnetic mounting seat (32) connected to one end of the connecting frame (31) and having a plurality of magnets mounted thereon; and A second magnetic mounting seat (33), connected to the other end of the connecting frame (31), opposite to the first magnetic mounting seat (32), and having a plurality of magnets mounted thereon; The driving mechanism (40) is used to drive the connecting frame (31) to rotate; the annular enclosure plate (21) is located between the first magnetic mounting seat (32) and the second magnetic mounting seat (33); a magnetic field is formed between the magnet on the first magnetic mounting seat (32) and the magnet on the second magnetic mounting seat (33).

4. A magnetic neural regulation experimental device for heat acclimatization and heat stroke research as claimed in claim 3, characterized in that: More than two of the experimental chambers (20) are arranged vertically; and the magnetic field generating mechanism (30) is arranged corresponding to the experimental chambers (20).

5. The magnetic nerve regulation experimental device for heat acclimatization and heat stroke research according to claim 4, characterized in that: The annular enclosure plate (21) can move vertically; The bottom support assembly (23) comprises: A first fan ring plate (231), the outer ring of which is connected to the inner wall of the lower end of the annular enclosure plate (21), and the inner ring of which is connected to the outer wall of the clearance sleeve (22); A first bearing (232) is sleeved on the relief sleeve (22) and is located below the first meniscus; and A second fan ring plate (233), the inner ring of which is connected to the outer ring of the first bearing (232); The second fan ring plate (233) and the first fan ring plate (231) can form a circular ring.

6. A magnetic nerve regulation experimental device for heat acclimatization and heat stroke research as claimed in claim 5, characterized in that: The connecting frame (31) comprises: A connecting plate (311) having a mounting hole thereon, wherein the connecting plate (311) is rotatably connected to the lower end of the giving way sleeve (22); and Two connecting rods (312) are provided, one end of each connecting rod (312) is connected to the connecting plate (311), and the other end of each connecting rod (312) is connected to the corresponding first magnetic mounting seat (32) or the second magnetic mounting seat (33); The driving mechanism (40) comprises: There are two or more drive sleeves (41), and the inner cavity cross section of the drive sleeve (41) is square. The outer wall of the drive sleeve (41) is connected to the inner wall of the mounting hole; A first driving rod (42) is arranged vertically and has a square cross section, and can be slidably matched with the inner wall of the driving sleeve (41) in the vertical direction; a second driving rod (43) connected to the lower end of the first driving rod (42) coaxially, the second driving rod (43) being rotatably disposed on the frame (10), the cross section of the second driving rod (43) being square and smaller than the cross section area of ​​the first driving rod (42); and The motor (44) is arranged on the frame (10), and its output end is connected to the lower end of the second driving rod (43).

7. A magnetic nerve regulation experimental device for heat acclimatization and heat stroke research as claimed in claim 6, characterized in that: The frame (10) comprises a plurality of columns (11); a vertical guide groove (12) is provided on the inner side of the column (11); a plurality of limit grooves (13) extending in the transverse direction are also provided on the inner side of the column (11); the plurality of limit grooves (13) are distributed in the vertical direction and are all connected to the guide groove (12); A plurality of guide plates (24) are connected to the outer wall of the annular enclosure plate (21); one end of the guide plate (24) away from the annular enclosure plate (21) is vertically slidably matched with the corresponding guide groove (12) and can be laterally inserted into the corresponding limit groove (13).

8. The magnetic nerve regulation experimental device for heat acclimatization and heat stroke research according to claim 7, characterized in that: The bottom support assembly (23) further comprises: A first baffle (234) is connected to one end of the first fan ring plate (231), and two ends of the first baffle (234) are respectively connected to the inner wall of the annular enclosure plate (21) and the outer wall of the clearance sleeve (22); Two limit blocks (235) are provided, and are respectively connected to both sides of the end of the second fan ring plate (233), and the limit blocks (235) can be close to the first baffle plate (234) as the second fan ring plate (233) rotates; and The second baffle (236) has sliding grooves at both ends, and the sliding grooves can be slidably matched with the corresponding limiting blocks (235) along the vertical direction.

9. The magnetic nerve regulation experimental device for heat acclimatization and heat stroke research according to claim 8, characterized in that: The diameters of the annular enclosure plates (21) are different.

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