Modeling device for mouse skin light aging experiment

By designing a mouse skin photoaging experimental molding device including fixed partitions, adjustable partitions, fixed slides and telescopic slides, the problem of uneven light source illumination is solved, and the accuracy of experimental data and practicality of experiments are achieved.

CN119969285APending Publication Date: 2025-05-13SICHUAN HEALTH REHABILITATION VOCATIONAL COLLEGE

Patent Information

Application Number
CN202510302311.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-03-14
Publication Date
2025-05-13

AI Technical Summary

Technical Problem

In the existing mouse skin photoaging experimental modeling machine, the light source irradiation is uneven, resulting in inaccurate experimental data.

Method used

A molding device including a box, a box cover, a fixed partition, an adjusting partition, a fixed slide and a telescopic slide were designed. The experimental channel space was adjusted through the linkage mechanism, and the position and angle of the ultraviolet lamp source were adjusted through the adjustment mechanism to ensure that the light source on the back of the mouse was consistent.

Benefits of technology

The uniformity of light source irradiation of mouse skin photoaging experiments is achieved, ensuring the accuracy of experimental data, and at the same time facilitating staff to capture mice, increasing the practicality of the experiment.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN119969285A_ABST
    Figure CN119969285A_ABST
Patent Text Reader

Abstract

The invention discloses a modeling device for a mouse skin light aging experiment, and relates to the technical field of skin light aging experiments, the modeling device comprises a box body, a box cover is hinged to the upper end of the box body, a bottom plate is fixedly arranged in the box body, a plurality of fixed partition plates are arranged at the upper end of the bottom plate, and adjusting partition plates are arranged on one sides of the fixed partition plates; fixed sliding plates are arranged on one sides of the fixed partition plates in a sliding mode, telescopic sliding plates are arranged at one ends of the fixed sliding plates in a sleeving and sliding mode, a linkage mechanism is arranged on one side of the box body, and irradiation components are arranged in the box cover and above the experiment channel. The linkage mechanism drives the adjusting partition plate, the fixed sliding plate and the telescopic sliding plate to move, so that when an irradiation experiment is carried out, the space of an experiment channel can be reduced, the activity range of a mouse is limited, and the distance between the two ultraviolet lamp sources and the irradiation angle of the ultraviolet lamp sources can be adjusted through the adjusting mechanism; therefore, irradiation in different states can be simulated conveniently.
Need to check novelty before this filing date? Find Prior Art

Description

Technical Field

[0001] The invention relates to the technical field of skin photoaging experiments, in particular to a modeling device for mouse skin photoaging experiments. Background Art

[0002] Skin photoaging is a type of exogenous skin aging, which is skin damage caused by repeated exposure to natural light or artificial ultraviolet light sources. In recent years, due to the destruction of the ozone layer and the increase in ultraviolet radiation, the incidence of photoaging has increased year by year, seriously threatening people's health and life. In medical research, skin aging has become a hot scientific issue that concerns everyone. Among them, exogenous skin aging is a type of aging that can be intervened through active prevention and repair. The main cause of exogenous skin aging is aging caused by ultraviolet light, and mouse skin photoaging experiments are an indispensable means for studying exogenous skin aging. Skin photoaging experiments are usually conducted on mice. Box-type experimental containers are used to simulate the ultraviolet irradiation environment of natural light proportions, and the skin on the back of mice is irradiated.

[0003] The announcement number is: CN221308371U, which discloses a modeling device for mouse skin photoaging experiments. The modeling device has the advantages of separating the placement of farmed mice through a box body, a box cover, a simulated sunlight mechanism, a partition, a display, a feed delivery port, and a ventilation window, so as to prevent the mice from gathering and lying flat. Through the cooperation of a rotating rod, a connecting plate, EVA and EVB light sources, gear one, a servo motor and gear two, it has the advantages of simulating light experiments. A row of light sources is arranged in the box body, which rotates at a certain speed along the top of the box cover. However, when the above-mentioned modeling device is in use, although the mice can be separated by the partition, the passage after separation is long, which is not convenient for irradiating the mouse skin at a fixed position. In addition, the light source in the above-mentioned modeling device will rotate around a point, but the irradiation position change range of the light source in the center position is small, and this irradiation range is gradually reduced. Combined with the movement of the mice in the passage and the rotation of the light source, it is easy to cause inaccurate experimental data.

[0004] Based on this, a modeling device for mouse skin photoaging experiments is now provided, which can eliminate the disadvantages of existing devices. Summary of the invention

[0005] The purpose of the present invention is to provide a modeling device for mouse skin photoaging experiments to solve the problem of inconsistent light source levels on the back of mice in the background technology.

[0006] To achieve the above object, the present invention provides the following technical solutions: The modeling device for mouse skin photoaging experiment comprises a box body, wherein the upper end of the box body is hinged with a box cover, the box body is fixedly provided with a bottom plate inside, the upper end of the bottom plate is fixedly provided with a plurality of fixed partitions at equal intervals, one side of the fixed partition is provided with an adjustment partition, the adjustment partition is slidably arranged on the upper end of the bottom plate, one side of the fixed partition is slidably provided with a fixed slide plate, one end of the fixed slide plate is sleeved and slidably provided with a telescopic slide plate, the telescopic slide plate is slidably arranged on one side of the adjustment partition, the fixed partition plate, the adjustment partition plate, the fixed slide plate and the telescopic slide plate are combined to form an experimental channel, one side of the box body is provided with a linkage mechanism for adjusting the experimental channel space, the inside of the box cover and the upper part of the experimental channel are provided with an irradiation component, the irradiation component comprises two symmetrically arranged ultraviolet light sources, the outer sides of the ultraviolet light sources are matched with condensers, the two ends of the condenser are respectively rotatably provided with a sliding frame and a limit slide block, the sliding frame and the limit slide block are respectively slidably arranged on two first guide slide bars, the first guide slide bar is fixedly arranged inside the box cover, and the box cover is provided with an adjustment mechanism for adjusting the working position of the ultraviolet light source.

[0007] On the basis of the above technical solution, the present invention also provides the following optional technical solution: In an optional scheme: the linkage mechanism includes a first mounting rod and a second mounting rod, and several of the adjusting partitions are fixed on the first mounting rod, one end of the first mounting rod extends to the outside of the box body, and a first tension spring is provided between one end of the first mounting rod and one side of the box body, and several of the fixed slide plates are fixed at the bottom end of the second mounting rod, and both ends of the second mounting rod extend to the outside of the box body, and limiting sliding grooves are provided at the positions corresponding to the two ends of the second mounting rod on both sides of the box body, and a threaded block is fixed at one end of the second mounting rod, and a threaded hole and a sliding hole are provided on one side of the threaded block, and a threaded rod is matched in the threaded hole, and a rotating plate is rotatably provided at both ends of the threaded rod, and the rotating plate is fixed on one side of the box body, and a second guide sliding rod is slidably provided in the sliding hole, and the second guide sliding rod is fixed between the two rotating plates, and a guide plate is fixed at one end of the first mounting rod, and a sliding column is slidably provided at one end of the guide plate, and the sliding column is fixed on one side of the box body, and a return spring is provided between one end of the guide plate and one end of the sliding column, and a lever is closely attached to the inclined section of the guide plate, and the lever is fixed at the bottom end of the threaded block.

[0008] In an optional scheme: the adjustment mechanism includes a connecting rod, a first fixed seat is fixedly provided on one side of the sliding frame, a connecting rod is hinged on the first fixed seat, two connecting rods are hinged at two ends of a hinge rod, the hinge rods are fixed at the bottom ends of the third mounting rod, the third mounting rod is fixed on the output end of the second electric push rod, the second electric push rod is fixed at the upper end of the inside of the box cover, several of the ultraviolet lamp sources are electrically connected to the manipulator, the manipulator is fixed at the upper end of the box cover, and one end of the focus cover is provided with a rotating component for adjusting the irradiation angle of the ultraviolet lamp source.

[0009] In an optional scheme: the rotating assembly includes a gear, a gear is fixedly provided on the rotating shaft at one end of the condenser, a rack is meshed on the gear, the rack is slidably arranged in a T-shaped slide groove at the bottom end of the fourth mounting rod, the fourth mounting rod is fixedly connected to the output ends of two third electric push rods respectively, the third electric push rods are fixedly arranged at the upper end of the box cover, and the rack is slidably arranged in the sliding groove at the upper end of the limiting slider.

[0010] In an optional solution: feeding holes are provided on one side of the box and at one end of several experimental channels, feeding boxes are provided on one side of the box and at the feeding holes, guide groove rods are slidably provided on both sides of the feeding boxes, and the guide groove rods are fixed on one side of the box.

[0011] In an optional solution: an observation window is provided at the upper end of the box cover, and the observation window is made of transparent material.

[0012] In an optional scheme: a plurality of leakage holes are provided at the upper end of the base plate and the position of the experimental channel, plugs are slidably provided in the leakage holes, the plurality of plugs are fixedly provided on the upper end of the mounting frame, a plurality of third guide slide bars are slidably provided on the mounting frame, the third guide slide bars are fixedly provided on the bottom end of the base plate, the bottom end of the mounting frame is respectively fixedly connected to the output ends of the two first electric push rods, the first electric push rod is fixedly provided on the upper end of the support plate, the support plate is fixedly provided at one end of the third guide slide bar, and a collection box is provided at the bottom end of the box body.

[0013] In an optional scheme: a scraper is slidably provided at the upper end of the bottom plate corresponding to the position of one end of the experimental channel, and several of the scrapers are fixed on the fifth mounting rod, one end of the fifth mounting rod is fixedly provided with a connecting frame, and the connecting frame extends to the outside of the box body, one end of the connecting frame is fixedly provided with a first fixing plate, one side of the first fixing plate is fixedly provided with a second magnet, one end of the second mounting rod is fixedly provided with a first magnet at the position corresponding to the second magnet, the other side of the first fixing plate is fixedly provided with a second tension spring, the other end of the second tension spring is fixedly connected to one side of the second fixing plate, the second fixing plate is fixedly provided on one side of the box body, one side of the first fixing plate is fixedly connected to the output end of the damping telescopic rod, the damping telescopic rod is fixedly provided on one side of the box body, and several of the scrapers are slidably provided on one side of several adjusting partitions respectively.

[0014] Compared with the prior art, the present invention has the following beneficial effects: The present invention arranges a plurality of fixed partitions at equal intervals on the upper end of a bottom plate, and an adjustable partition is arranged on one side of the fixed partition, and a fixed slide plate and a telescopic slide plate are arranged between the fixed partition and the adjustable partition, and a linkage mechanism is used to drive the adjustable partition, the fixed slide plate and the telescopic slide plate to move, so that when performing an irradiation experiment, the space of the experimental channel can be reduced to limit the activity range of mice, and at the same time, ultraviolet light sources are symmetrically arranged above the experimental channel, and the spacing between the two ultraviolet light sources and the irradiation angle of the ultraviolet light sources can be adjusted through the adjustment mechanism, so that it is convenient to simulate irradiation in different states, so that the irradiation light source on the back of the mouse is consistent, thereby ensuring the accuracy of the experiment, and at the same time, by changing the size of the experimental channel space, it is also convenient for staff to catch mice, thereby increasing the practicality of the mouse skin photoaging experiment modeling device. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a structural schematic diagram of the present invention.

[0016] Figure 2 It is a schematic diagram of the connection between the box body and the box cover of the present invention.

[0017] Figure 3 It is a schematic diagram of the structure of the mounting frame of the present invention.

[0018] Figure 4 This is a schematic diagram of the installation of the fixed partition and the adjustable partition of the present invention.

[0019] Figure 5 It is a schematic diagram of the connection between the fixed slide plate and the telescopic slide plate of the present invention.

[0020] Figure 6 This is a schematic diagram of installing the first mounting rod of the present invention.

[0021] Figure 7 It is a schematic diagram of the scraper structure of the present invention.

[0022] Figure 8 This is a schematic diagram of installing the condenser cover of the present invention.

[0023] Fig. 9 It is a schematic diagram of the rack structure of the present invention.

[0024] Fig.10 This is a schematic diagram of the gear installation of the present invention.

[0025] Notes on figure numbers: 11 box body, 12 box cover, 13 bottom plate, 14 collection box, 15 observation window, 16 manipulator, 17 feeding box, 18 fixed partition, 19 adjusting partition, 20 first mounting rod, 21 fixed slide, 22 telescopic slide, 23 second mounting rod, 24 threaded rod, 25 motor, 26 guide plate, 27 lever, 28 first tension spring, 29 return spring, 30 mounting frame, 31 first electric push rod, 32 scraper, 33 connecting frame, 34 first magnet, 35 second magnet, 36 second tension spring, 37 damping telescopic rod, 38 ultraviolet light source, 39 condenser, 40 connecting rod, 41 third mounting rod, 42 second electric push rod, 43 limiting slider, 44 gear, 45 rack, 46 fourth mounting rod, 47 third electric push rod. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. Example 1

[0027] In one embodiment, Figure 1-Figure 10As shown, a modeling device for a mouse skin photoaging experiment comprises a box body 11, wherein a box cover 12 is hingedly provided at the upper end of the box body 11, a bottom plate 13 is fixedly provided inside the box body 11, a plurality of fixed partitions 18 are fixedly provided at equal intervals at the upper end of the bottom plate 13, one side of the fixed partitions 18 is provided with an adjusting partition 19, the adjusting partition 19 is slidably provided on the upper end of the bottom plate 13, one side of the fixed partitions 18 is provided with a fixed slide plate 21 slidably, one end of the fixed slide plate 21 is sleeved and slidably provided with a telescopic slide plate 22, the telescopic slide plate 22 is slidably provided on one side of the adjusting partition plate 19, the fixed partition plates 18, the adjusting partition plates 19, the fixed slide plates 21 and the telescopic slide plates 22 are combined into an experimental channel, and one side of the box body 11 is provided with a linkage mechanism for adjusting the experimental channel space Structure, the inside of the box cover 12 and the top of the experimental channel are both provided with irradiation components, the irradiation components include two symmetrically arranged ultraviolet lamp sources 38, the outer sides of the ultraviolet lamp sources 38 are matched with condensers 39, the two ends of the condenser 39 are respectively rotatably provided with sliding frames and limit sliders 43, the sliding frames and limit sliders 43 are respectively slidably arranged on two first guide slide bars, the first guide slide bars are fixedly arranged inside the box cover 12, the box cover 12 is provided with an adjustment mechanism for adjusting the working position of the ultraviolet lamp source 38, through the linkage mechanism, it is convenient to drive the adjustment partition 19 and the fixed slide plate 21 to move, so as to adjust the experimental channel space, the adjustment mechanism is convenient for adjusting the working position of the ultraviolet lamp source 38, so as to facilitate the simulation of irradiation at different positions and angles; The linkage mechanism includes a first mounting rod 20 and a second mounting rod 23, a plurality of the adjusting baffles 19 are fixedly mounted on the first mounting rod 20, one end of the first mounting rod 20 extends to the outside of the box body 11, a first tension spring 28 is provided between one end of the first mounting rod 20 and one side of the box body 11, a plurality of the fixed slide plates 21 are fixedly mounted at the bottom end of the second mounting rod 23, both ends of the second mounting rod 23 extend to the outside of the box body 11, and limiting slide grooves are provided at the positions corresponding to the positions of the two ends of the second mounting rod 23 on both sides of the box body 11, and the second mounting rod 23 is provided with a plurality of fixed slide plates 21. A threaded block is fixed at one end, a threaded hole and a sliding hole are provided on one side of the threaded block, a threaded rod 24 is matched in the threaded hole, a rotating plate is rotatably provided at both ends of the threaded rod 24, the rotating plate is fixed on one side of the box body 11, a second guide slide bar is slidably provided in the sliding hole, the second guide slide bar is fixed between the two rotating plates, a guide plate 26 is fixed at one end of the first mounting rod 20, a sliding column is slidably provided at one end of the guide plate 26, the sliding column is fixed on one side of the box body 11, and a guide plate 26 is provided between one end of the guide plate 26 and one end of the sliding column. The guide plate 26 has a reset spring 29, and the inclined section of the guide plate 26 is tightly attached with a lever 27, and the lever 27 is fixed at the bottom end of the threaded block. When in use, when it is necessary to perform an irradiation experiment on the mice inside the experimental channel, the motor 25 is started, and the output end of the motor 25 drives the threaded rod 24 to rotate. Under the action of the thread, the threaded block drives the second mounting rod 23 to move along the axis direction of the second guide slide bar, and at the same time, the threaded block drives the lever 27 to move. Since the lever 27 is tightly attached to one side of the guide plate 26, the guide plate 26 drives the first mounting rod 20 to move, and the first mounting rod 20 drives A plurality of adjusting partitions 19 are moved to reduce the distance between the fixed partition 18 and the adjusting partition 19. At the same time, the second mounting rod 23 drives a plurality of fixed slides 21 to move, and the fixed slides 21 drive the telescopic slides 22 to move, so that the space of the experimental channel is reduced. The mice run to the other end of the experimental channel under the push of the fixed slides 21. When the lever 27 is in close contact with the flat end of the guide plate 26, the adjusting partition 19 no longer moves. When the experimental channel space only allows the mice to stand and cannot move, the fixed slides 21 stop moving. At this time, the mice can be subjected to irradiation experiments.

[0028] The adjusting mechanism includes a connecting rod 40, a first fixing seat is fixedly provided on one side of the sliding frame, a connecting rod 40 is hinged on the first fixing seat, two connecting rods 40 are hinged at both ends of a hinge rod, the hinge rods are fixed at the bottom end of a third mounting rod 41, the third mounting rod 41 is fixedly provided on the output end of a second electric push rod 42, the second electric push rod 42 is fixedly provided on the upper end of the box cover 12, a plurality of the ultraviolet lamp sources 38 are electrically connected to the controller 16, the controller 16 is fixedly provided on the upper end of the box cover 12, and when in use, when ultraviolet light sources 38 are required, During the line irradiation experiment, the switch of the ultraviolet lamp source 38 is controlled by the manipulator 16. When the irradiation position of the ultraviolet lamp source 38 needs to be adjusted, the second electric push rod 42 is started, and the second electric push rod 42 drives the third mounting rod 41 to move, and the third mounting rod 41 drives a plurality of hinge rods to move. The hinge rod drives the focus cover 39 to move through the connecting rod 40, and the two ultraviolet lamp sources 38 above an experimental channel move in opposite directions, thereby adjusting the irradiation position of the ultraviolet lamp source 38. A rotating component for adjusting the irradiation angle of the ultraviolet lamp source 38 is provided at one end of the focus cover 39.

[0029] The rotating assembly includes a gear 44, a gear 44 is fixedly provided on the rotating shaft at one end of the condenser 39, and a rack 45 is meshed on the gear 44, and the rack 45 is slidably arranged in the T-shaped slide groove at the bottom end of the fourth mounting rod 46, and the fourth mounting rod 46 is respectively fixedly connected to the output ends of two third electric push rods 47, and the third electric push rods 47 are fixedly arranged at the upper end of the box cover 12, and the rack 45 is slidably arranged in the sliding groove at the upper end of the limit slider 43. When in use, when it is necessary to adjust the irradiation angle of the ultraviolet lamp source 38, the third electric push rod 47 is started, and the output end of the third electric push rod 47 drives the fourth mounting rod 46 to move, and the fourth mounting rod 46 drives several racks 45 to move, and the rack 45 is meshed with the gear 44, so as to drive the condenser 39 to rotate, and the condenser 39 drives the ultraviolet lamp source 38 to rotate, so that the irradiation angle of the ultraviolet lamp source 38 is adjusted, thereby simulating different irradiation positions. At the same time, the irradiation power of the ultraviolet lamp source 38 in this application can be adjusted.

[0030] Feeding holes are provided on one side of the box 11 and at one end of several experimental channels. Feeding boxes 17 are provided on one side of the box 11 and at the positions of the feeding holes. Guide groove rods are slidably provided on both sides of the feeding box 17. The guide groove rods are fixed on one side of the box 11. When in use, when mice are undergoing irradiation simulation experiments, the heads of the mice can pass through the feeding holes to eat the food inside the feeding box 17.

[0031] An observation window 15 is disposed at the upper end of the box cover 12 . The observation window 15 is made of a transparent material, and when in use, it is convenient for the experimenter to observe the state of the mouse through the observation window 15 . Example 2

[0032] The difference from Example 1 is that: a plurality of leakage holes are provided at the upper end of the bottom plate 13 and the position of the experimental channel, and plugs are slidably provided in the leakage holes, and the plurality of plugs are fixedly provided on the upper end of the mounting frame 30, and a plurality of third guide slide bars are slidably provided on the mounting frame 30, and the third guide slide bars are fixedly provided at the bottom end of the bottom plate 13, and the bottom end of the mounting frame 30 is respectively fixedly connected to the output ends of two first electric push rods 31, and the first electric push rods 31 are fixedly provided on the upper end of the support plate, and the support plate is fixedly provided at one end of the third guide slide bar, and a collecting box 14 is provided at the bottom end of the box body 11. When in use, when the motor 25 is started, the manipulator 16 simultaneously controls the first electric push rod 31 to start, so that the output end of the first electric push rod 31 drives the mounting frame 30 to move, and the plugs are separated from the leakage holes. During the movement of the fixed slide 21 and the telescopic slide 22, the feces discharged by the mice at the upper end of the bottom plate 13 can be discharged into the collecting box 14 through the leakage holes for collection.

[0033] A scraper 32 is slidably provided at the upper end of the bottom plate 13 corresponding to one end of the experimental channel, and several of the scrapers 32 are fixed on the fifth mounting rod, and a connecting frame 33 is fixed at one end of the fifth mounting rod, and the connecting frame 33 extends to the outside of the box body 11, and a first fixed plate is fixed at one end of the connecting frame 33, and a second magnet 35 is fixedly provided on one side of the first fixed plate, and a first magnet 34 is fixedly provided at one end of the second mounting rod 23 corresponding to the position of the second magnet 35, and a second tension spring 36 is fixedly provided on the other side of the first fixed plate, and the other end of the second tension spring 36 is fixedly connected to one side of the second fixed plate, and the second fixed plate is fixedly provided on one side of the box body 11, and one side of the first fixed plate is fixedly connected to the output end of the damping telescopic rod 37, and the damping telescopic rod 37 is fixedly provided on one side of the box body 11, and several of the scrapers 32 are respectively slidably provided on one side of several adjusting partitions 19. When in use, when the second mounting rod 23 drives several fixed slides 21 to move, the second mounting rod 23 drives the first magnet 34 to move. When the first magnet 34 and the second magnet 35 When the fixed slide plate 21 is in close contact, the first magnet 34 and the second magnet 35 are attracted to each other. When the irradiation experiment is completed, the output end of the motor 25 drives the threaded rod 24 to rotate in the opposite direction, so that the fixed slide plate 21 moves to the initial position. At the same time, due to the mutual attraction between the first magnet 34 and the second magnet 35, the second mounting rod 23 drives the plurality of scrapers 32 to move through the connecting frame 33 and the fifth mounting rod. The scrapers 32 push the feces at the upper end of the bottom plate 13 where the leakage hole is not set to the leakage hole, so that the feces falls into the collection box 14. At the same time, after the scraper 32 moves to the leakage hole, the outer slide groove of the box body 11 limits the connection frame 33 to continue to move, so that the first magnet 34 is separated from the second magnet 35, and the scraper 32 returns to the initial position under the action of the second tension spring 36, and the movement speed of the scraper 32 is slowed down under the action of the damping telescopic rod 37. When the fixed slide 21 and the telescopic slide 22 move to the initial position, under the action of the first tension spring 28 and the return spring 29, the several adjustment partitions 19 return to the initial position, and the plug seals the leakage hole.

[0034] The above-mentioned embodiment discloses a modeling device for a mouse skin photoaging experiment, wherein, when it is necessary to perform an irradiation experiment on the mice inside the experimental channel, the motor 25 is started, and the output end of the motor 25 drives the threaded rod 24 to rotate. Under the action of the thread, the thread block drives the second mounting rod 23 to move along the axis direction of the second guide slide bar, and at the same time, the thread block drives the lever 27 to move. Since the lever 27 is in close contact with one side of the guide plate 26, the guide plate 26 drives the first mounting rod 20 to move, and the first mounting rod 20 drives a plurality of adjusting partitions 19 to move, so that the distance between the fixed partition 18 and the adjusting partition 19 is reduced, and at the same time, the second mounting rod 23 drives a plurality of fixed slides 21 to move, and the fixed slides 21 drive The telescopic slide 22 moves, so that the space of the experimental channel is reduced, and the mouse runs to the other end of the experimental channel under the push of the fixed slide 21. The manipulator 16 controls the first electric push rod 31 to start at the same time, so that the output end of the first electric push rod 31 drives the mounting frame 30 to move, and the plug is separated from the leak hole. During the movement of the fixed slide 21 and the telescopic slide 22, the feces discharged by the mouse at the upper end of the bottom plate 13 can be discharged into the collection box 14 through the leak hole for collection. When the lever 27 is in close contact with the flat end of the guide plate 26, the adjustment partition 19 no longer moves. When the experimental channel space only allows the mouse to stand and cannot move, the fixed slide 21 stops moving, and the first magnet 34 and the second magnet 35 are attracted to each other. Subsequently, the switch of the ultraviolet lamp source 38 is controlled by the manipulator 16 to carry out an irradiation experiment. When the irradiation position of the ultraviolet lamp source 38 needs to be adjusted, the second electric push rod 42 is started, and the second electric push rod 42 drives the third mounting rod 41 to move, and the third mounting rod 41 drives a plurality of hinge rods to move, and the hinge rod drives the focus cover 39 to move through the connecting rod 40, and the movement directions of the two ultraviolet lamp sources 38 above an experimental channel are opposite, so that the irradiation position of the ultraviolet lamp source 38 is adjusted. When the irradiation angle of the ultraviolet lamp source 38 needs to be adjusted, the third electric push rod 47 is started, and the output end of the third electric push rod 47 drives the fourth mounting rod 46 to move, and the fourth mounting rod 46 drives a plurality of racks 45 to move, and the racks 45 are meshed with the gears 44, so that the focus cover 39 is driven to rotate, and the focus cover 39 drives the ultraviolet lamp source 38 to rotate, so that the irradiation angle of the ultraviolet lamp source 38 is adjusted, thereby simulating different irradiation positions.

[0035] The above is only a specific implementation of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art who is familiar with the present technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.

Claims

1. A modeling device for a mouse skin photoaging experiment, comprising a box body (11), a box cover (12) is hingedly provided at the upper end of the box body (11), a bottom plate (13) is fixedly provided inside the box body (11), a plurality of fixed partitions (18) are fixedly provided at equal intervals at the upper end of the bottom plate (13), an adjustable partition (19) is provided on one side of each fixed partition (18), and the adjustable partition (19) is slidably provided on the upper end of the bottom plate (13), characterized in that: A fixed slide plate (21) is slidably provided on one side of the fixed partition (18), and a telescopic slide plate (22) is slidably provided on one end of the fixed slide plate (21). The telescopic slide plate (22) is slidably provided on one side of the adjustment partition (19). The fixed partition (18), the adjustment partition (19), the fixed slide plate (21) and the telescopic slide plate (22) are combined to form an experimental channel. A linkage mechanism for adjusting the space of the experimental channel is provided on one side of the box body (11). An irradiation component is provided inside the box cover (12) and above the experimental channel. The irradiation component includes two symmetrically arranged ultraviolet light sources (38). A condenser (39) is provided on the outside of the ultraviolet light sources (38). A sliding frame and a limit slider (43) are rotatably provided at both ends of the condenser (39). The sliding frame and the limit slider (43) are slidably provided on two first guide slide bars, respectively. The first guide slide bars are fixedly provided inside the box cover (12). An adjustment mechanism for adjusting the working position of the ultraviolet light source (38) is provided inside the box cover (12).

2. The modeling device for mouse skin photoaging experiment according to claim 1, characterized in that: The linkage mechanism comprises a first mounting rod (20) and a second mounting rod (23), a plurality of the adjusting baffles (19) are fixedly mounted on the first mounting rod (20), one end of the first mounting rod (20) extends to the outside of the box body (11), a first tension spring (28) is provided between one end of the first mounting rod (20) and one side of the box body (11), a plurality of the fixed slide plates (21) are fixedly mounted on the bottom end of the second mounting rod (23), both ends of the second mounting rod (23) extend to the outside of the box body (11), limiting sliding grooves are provided at positions corresponding to the two ends of the second mounting rod (23) on both sides of the box body (11), a threaded block is fixedly mounted on one end of the second mounting rod (23), and one side of the threaded block A threaded hole and a sliding hole are provided, a threaded rod (24) is matched in the threaded hole, and rotating plates are rotatably provided at both ends of the threaded rod (24), and the rotating plates are fixedly arranged on one side of the box body (11). A second guide sliding rod is slidably provided in the sliding hole, and the second guide sliding rod is fixedly arranged between the two rotating plates. A guide plate (26) is fixedly provided at one end of the first mounting rod (20), and a sliding column is slidably provided at one end of the guide plate (26), and the sliding column is fixedly arranged on one side of the box body (11). A return spring (29) is provided between one end of the guide plate (26) and one end of the sliding column, and a shifting rod (27) is tightly attached to the inclined section of the guide plate (26), and the shifting rod (27) is fixedly arranged at the bottom end of the threaded block.

3. The modeling device for mouse skin photoaging experiment according to claim 1, characterized in that: The adjustment mechanism comprises a connecting rod (40), a first fixing seat is fixedly provided on one side of the sliding frame, a connecting rod (40) is hingedly provided on the first fixing seat, two connecting rods (40) are hingedly provided at two ends of a hinge rod, the hinge rod is fixedly provided at the bottom end of a third mounting rod (41), the third mounting rod (41) is fixedly provided on the output end of a second electric push rod (42), the second electric push rod (42) is fixedly provided at the upper end inside the box cover (12), a plurality of the ultraviolet light sources (38) are electrically connected to a controller (16), the controller (16) is fixedly provided at the upper end of the box cover (12), and a rotating component for adjusting the irradiation angle of the ultraviolet light source (38) is provided at one end of the condenser (39).

4. The modeling device for mouse skin photoaging experiment according to claim 3, characterized in that: The rotating assembly comprises a gear (44), a gear (44) is fixedly provided on a rotating shaft at one end of the condenser (39), a rack (45) is meshed on the gear (44), the rack (45) is slidably arranged in a T-shaped slide groove at the bottom end of a fourth mounting rod (46), the fourth mounting rod (46) is respectively fixedly connected to the output ends of two third electric push rods (47), the third electric push rods (47) are fixedly arranged at the upper end of the box cover (12), and the rack (45) is slidably arranged in a slide groove at the upper end of a limit slider (43).

5. The modeling device for mouse skin photoaging experiment according to claim 1, characterized in that: Feeding holes are provided at one side of the box (11) and at one end of the plurality of experimental channels, feeding boxes (17) are provided at one side of the box (11) and at the positions of the feeding holes, guide groove rods are slidably provided on both sides of the feeding box (17), and the guide groove rods are fixedly provided on one side of the box (11).

6. The modeling device for mouse skin photoaging experiment according to claim 1, characterized in that: An observation window (15) is provided at the upper end of the box cover (12), and the observation window (15) is made of a transparent material.

7. The modeling device for mouse skin photoaging experiment according to claim 2, characterized in that: A plurality of leakage holes are provided at the upper end of the bottom plate (13) and at the position of the experimental channel, plugs are slidably provided in the leakage holes, and the plurality of plugs are fixedly provided at the upper end of the mounting frame (30), and a plurality of third guide slide bars are slidably provided on the mounting frame (30), and the third guide slide bars are fixedly provided at the bottom end of the bottom plate (13), and the bottom end of the mounting frame (30) is respectively fixedly connected to the output ends of two first electric push rods (31), and the first electric push rods (31) are fixedly provided at the upper end of the support plate, and the support plate is fixedly provided at one end of the third guide slide bar, and a collection box (14) is provided at the bottom end of the box body (11).

8. The modeling device for mouse skin photoaging experiment according to claim 7, characterized in that: A scraper (32) is slidably provided at the upper end of the bottom plate (13) at a position corresponding to one end of the experimental channel, and a plurality of the scrapers (32) are fixedly provided on a fifth mounting rod. A connecting frame (33) is fixedly provided at one end of the fifth mounting rod, and the connecting frame (33) extends to the outside of the box body (11). A first fixing plate is fixedly provided at one end of the connecting frame (33), and a second magnet (35) is fixedly provided at one side of the first fixing plate. A first magnet (34) is fixedly provided at one end of the second mounting rod (23) at a position corresponding to the position of the second magnet (35). A second tension spring (36) is fixedly provided at the other side of the first fixing plate, and the other end of the second tension spring (36) is fixedly connected to one side of the second fixing plate. The second fixing plate is fixedly provided at one side of the box body (11), and one side of the first fixing plate is fixedly connected to an output end of a damping telescopic rod (37). The damping telescopic rod (37) is fixedly provided at one side of the box body (11). The plurality of scrapers (32) are slidably provided at one side of a plurality of adjustment partitions (19), respectively.

Citation Information

Patent Citations

  • Modeling device for mouse skin light aging experiment

    CN221308371U

Cited By

  • Cesarean operation bin

    CN120959154A