Mouse observation recording device for drug test
By designing a mouse observation and recording device for drug tests, including an observation and recording box, atomized drug delivery mechanism, mouse feces collection and recording mechanism and mouse binding fixing scaffold, the problem of inconvenience in the existing technology of mice and easy to be broken away by electrode sheets is solved, and effective monitoring and recording of mouse drug tests is achieved.
Patent Information
- Application Number
- CN202510369758.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-27
- Publication Date
- 2025-05-13
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The prior art lacks effective instruments for the observation and recording of mice in drug tests, resulting in puncture trauma affecting the body function of mice, and the electrode sheet is easily broken away by the movement of mice, affecting the monitoring effect.
A mouse observation and recording device for drug testing was designed, including an observation and recording box, a nebulized drug delivery mechanism, a mouse feces collection and recording mechanism, and a mouse binding fixing stent. The observation and recording box realizes drug administration through a nebulized drug delivery mechanism. The feces collection and recording mechanism separates and collects feces and urine, binds and fixes the stent to control the posture of the mouse, so as to facilitate the attachment and monitoring of electrode sheets.
The device can effectively protect mice, reduce the impact of puncture trauma on mice, and collect mouse excrement through atomization administration and isolation to achieve detailed monitoring and recording of mouse body changes.
Smart Images
Figure CN119969286A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of experimental animal observation and recording instruments, and in particular to a mouse observation and recording device for drug experiments. Background Art
[0002] In the drug development test stage, mice are used as experimental subjects, and drugs are often injected into the mouse body, and the physical changes of the mice are observed to learn the side effects of the drugs and their intensity. The inventors found that in the observation and recording stage after the mice were given the drug, since most of the experimental drugs were injected into the mice, the puncture trauma caused by the injection would undoubtedly have a certain impact on the body functions of the mice. Secondly, there is a lack of instruments for observing and recording mice at this stage, resulting in the current stage of observing mice by building pens. In addition, the means for monitoring the functions of mice are usually various types of electrode sheets, and there are wire harnesses between the electrode sheets and the recording machine. If the mice cannot be effectively restricted without harming the mice, the electrode sheets may be affected by the activities of the mice and break free. Summary of the invention
[0003] The purpose of the present invention is to provide a mouse observation and recording device for drug testing in view of the defects of the above-mentioned background technology.
[0004] The above-mentioned object of the present invention is achieved by the following technical solutions:
[0005] A mouse observation and recording device for drug testing, comprising an observation and recording box, an atomization drug delivery mechanism is arranged on the right side of the top surface of the observation and recording box, two groups of mouse restraint fixing brackets are fixedly connected in the inner cavity of the observation and recording box, and a mouse feces collection and recording mechanism is arranged on the bottom surface of the observation and recording box;
[0006] The observation and recording box includes a box body, a box cover that is buckled and connected to the upper port of the box body, and a hatch that is connected to the left space of the box body and the box cover; specifically, mice are put between the box body and the box cover, and appropriate amounts of food and water are placed inside the observation and recording box. The box body and the box cover are mutually connected and coupled through the convex strips and grooves between the box body and the box cover. Before that, the two convex rods at the bottom of the hatch are inserted into the through holes on the left end face of the box body. After the box cover is closed, the two convex rods at the top of the hatch are inserted into the through holes on the left end face of the box cover, thereby forming a sealed space. At the same time, the top middle area of the box cover has a downwardly concave groove, and various data are filled in on a card or paper and attached to the groove. The card or paper has information such as the weight of the mouse, the test drug, etc.
[0007] The mouse feces collection and recording mechanism includes a feces collection bin, a hollow partition fixed to the top port of the feces collection bin, and a square slot inserted into the inner cavity of the feces collection bin, wherein a filter plate is fixedly connected to the inner cavity of the square slot; specifically, after the mice are dosed, the mice can be allowed to move inside the observation and recording box in the early stage, and their excrement will enter the square slot through the holes on the hollow partition after the mice eat and drink water. At this time, the granular solid feces are blocked by the filter plate and remain in the upper layer, while the urine enters the lower layer of the inner cavity of the square slot. After the square slot is pulled out by pulling the handle, the changes in the mouse excrement after the medication can be obtained.
[0008] The two groups of mouse restraint fixing brackets include two columns, a support seat fixed on the top of the column, and a connecting rod rotatably arranged between the support seats, a screw rod is arranged inside the connecting rod, a hollow tube is arranged at the end of the screw rod, an L-shaped support plate is fixed at the bottom end of the hollow tube, a movable sheet is hinged at the top end of the L-shaped support plate, arc-shaped clamping claws are fixed at the bottom ends of the movable sheet and the L-shaped support plate, and a screw rod is arranged between the movable sheet and the L-shaped support plate, and an internal threaded sleeve is screwed on the outer ring of the screw rod; specifically, after the mouse has been active for a period of time, the operator catches the mouse by opening the hatch, and places the mouse's body between the two groups of arc-shaped clamping claws, drives the L-shaped support plate and the movable sheet to approach each other by screwing the internal threaded sleeve, and then brings the arc-shaped clamping claws close to each other to clamp the front and rear sections of the mouse's body, and on the basis of restricting the mouse's activity, muscle electrode sheets and EEG electrode sheets are respectively attached to the mouse to detect the body changes of the mouse after drug administration.
[0009] The atomizing drug delivery mechanism includes a small water pump and a medicine box connected by a pipeline. The discharge port of the small water pump is connected to a liquid guide tube through a pipe joint. The bottom surface of the liquid guide tube is penetrated by 7-9 manifolds that penetrate into the inner cavity of the observation and recording box. Atomizing nozzles are installed on the ends of the manifolds located in the inner cavity of the observation and recording box.
[0010] Specifically, after the experimental drug is injected into the medicine box through the injection port on the top of the medicine box, the internal photoelectric liquid level sensor of the medicine box will detect the liquid level of the drug. A small water pump transports the drug to the liquid guide tube through the liquid extraction pipeline. Since the liquid guide tube is in the shape of a square, and the manifold under the liquid guide tube is located between the box body and the box cover, the drug is transported to the inside of the atomizing nozzle through the guidance of the manifold. Under the atomization effect of the atomizing nozzle, the drug diffuses between the box body and the box cover, thereby achieving drug administration to the mice.
[0011] Furthermore, 20-30 ventilation grilles are provided on the front and rear side walls of the box body and the box cover, a circle of convex strips are fixed on the edge of the bottom end face of the box body, and a circle of grooves for the convex strips to be inserted into are provided on the edge of the top end face of the box cover.
[0012] Furthermore, the left side end surfaces of the box body and the box cover are provided with a notch for the hatch to be embedded and placed, the top and bottom of the hatch are fixed with two protruding rods, and the left side end surfaces of the box body and the box cover are provided with a through hole for the protruding rods to be inserted and coupled.
[0013] Furthermore, a circle of circular holes for the manifold to pass through is opened on the top of the box body, and the interior of the circular holes is filled with sealing rings that match the outer ring of the manifold. An opening is opened on the bottom end face of the box cover, and the outer surface of the hollow partition is fixed in the inner cavity of the opening.
[0014] Furthermore, a square through hole is provided on the rear end surface of the feces collection bin for the square groove to be inserted and slid forward and backward, and a support bar is fixedly connected to the left and right side walls of the inner cavity of the feces collection bin, and the left and right sides of the bottom end surface of the square groove are in sliding contact with the top surface of the support bar respectively.
[0015] Furthermore, the interior of the hollow partition is provided with a plurality of through holes for mouse feces and urine to pass through, and the top end surface of the hollow partition is flush with the bottom surface of the inner cavity of the box body; the interior of the filter plate is provided with a plurality of filter holes for filtering feces and allowing urine to flow downward, and the filter plate divides the inner cavity space of the square groove into two parts, the upper inner cavity space of the square groove is used to carry feces, and the lower inner cavity space of the square groove is used to collect mouse urine, and a pull-out handle is fixedly connected to the rear end surface of the square groove by screws.
[0016] Furthermore, the bottom ends of the columns are fixedly connected to the top surface of the hollow partition, a servo motor is installed on the side wall of the rear support seat, the output shaft of the servo motor is fixedly connected to one end of the connecting rod, the other end of the connecting rod is rotatably connected to the side wall of the servo motor on the front side, a plurality of equidistantly arranged through holes are opened in the inner cavity of the connecting rod, nuts are screwed on the sections where the screw passes through the through holes and the screw is located outside the through holes.
[0017] Furthermore, a circular hole for the screw to pass through is opened inside the hollow tube, a locking screw passes through the top of the hollow tube, and the side wall of the screw located in the inner cavity of the hollow tube is in close contact with the bottom end of the locking screw.
[0018] Furthermore, the inside of the L-shaped support plate and the movable plate are both provided with openings for the screw rod to pass through, and a limit block with a diameter larger than the opening is fixed to the front end of the screw rod, and a thread is provided on the section of the screw rod away from the limit block, and a screw thread matching the outer circle thread of the screw rod is provided in the inner cavity of the internally threaded sleeve, and the end face of the internally threaded sleeve close to the L-shaped support plate is in close contact with the outer side wall, and a cylindrical spring sleeved on the outer circle of the screw rod is fixed to the side walls close to each other of the L-shaped support plate and the movable plate, and the arc-shaped claws are all arc-shaped and the side of the arc-shaped claws close to each other is in contact with the body of the mouse.
[0019] Furthermore, the bottom surface of the medicine box is fixedly connected to the top surface of the box cover, the liquid extraction port of the small water pump is connected to a liquid extraction pipeline that penetrates into the inner cavity of the medicine box, and the liquid guide tube is in the shape of a "mouth" as a whole.
[0020] It can be seen from the above technical scheme that the present invention provides a mouse observation and recording device for drug testing. Compared with the prior art, the present invention has the following beneficial effects:
[0021] 1. A split observation and recording box structure is set up to ensure that the mice are properly kept during the observation period. The small size of the observation and recording box can be carried easily, and the functional changes of the mice after drug administration can be observed intuitively.
[0022] 2. An atomization drug delivery mechanism is set on the observation and recording box, which can deliver drugs when the mice are in normal survival and movement. It has the effects of real-time and intermittent drug delivery, and can supplement drugs for mice at any time as needed.
[0023] 3. A mouse feces collection and recording mechanism is set at the bottom of the observation and recording box, and the mouse feces after administration are collected by using a square groove that can be pulled out inside the feces collection bin. At the same time, the filter plate inside the square groove can separate and collect the mouse feces and urine, and the physical changes of the mouse after administration are recorded through feces and urine.
[0024] 4. A mouse restraint fixing bracket is set inside the observation and recording box, so that the posture of the mouse in the box can be controlled, which makes it convenient for the operator to attach electrodes to the mouse and observe the changes of the mouse when it is stationary. BRIEF DESCRIPTION OF THE DRAWINGS
[0025] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces and describes the drawings required for use in the embodiments of the present invention or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention, and for ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.
[0026] Figure 1 This is a schematic diagram of the overall structure of the mouse observation and recording box;
[0027] Figure 2 This is a schematic diagram of the observation record box after it is disassembled;
[0028] Figure 3 Schematic diagram of the recording mechanism for collecting mouse feces;
[0029] Figure 4 Schematic diagram of the restraint and fixation bracket for mice;
[0030] Figure 5 This is a magnified schematic diagram of the mouse restraint fixation bracket;
[0031] Figure 6 It is a schematic diagram of the atomization drug delivery mechanism.
[0032] Attached Figure 1 -Attached Figure 6 The corresponding relationship of the parts is as follows:
[0033] 1. Observation and recording box; 11. Box body; 12. Box cover; 13. Hatch door; 2. Mouse feces collection and recording mechanism; 21. Feces collection bin; 22. Hollow partition; 23. Support bar; 24. Filter plate; 25. Pull-out handle; 26. Square groove; 3. Mouse restraint fixing bracket; 31. Column; 32. Support seat; 33. Servo motor; 34. Connecting rod; 35. Screw; 36. Locking screw; 37. Hollow tube; 38. L-shaped support plate; 39. Screw; 310. Cylindrical spring; 311. Arc-shaped clamp; 312. Movable sheet; 313. Internal threaded sleeve; 4. Atomization drug delivery mechanism; 41. Small water pump; 42. Medicine box; 43. Liquid extraction pipeline; 44. Manifold; 45. Atomization nozzle; 46. Liquid guide tube. DETAILED DESCRIPTION
[0034] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described below are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0035] In order to more clearly explain and illustrate the technical solution and implementation of the present invention, preferred specific embodiments for implementing the technical solution of the present invention are introduced below.
[0036] Example 1: A preferred technical solution for a drug test mouse observation and recording device, see the attached manual. Figure 1 -Attached Figure 6As shown, it includes an observation and recording box 1, an atomization drug delivery mechanism 4 is arranged on the right side of the top surface of the observation and recording box 1, two groups of mouse restraint fixing brackets 3 are fixedly connected in the inner cavity of the observation and recording box 1, and a mouse feces collecting and recording mechanism 2 is arranged on the bottom surface of the observation and recording box 1; the observation and recording box 1 includes a box body 11, a box cover 12 which is buckled and connected to the upper port of the box body 11, and a hatch 13 which is connected to the left space of the box body 11 and the box cover 12; the mouse feces collecting and recording mechanism 2 includes a feces collecting bin 21, a hollow partition plate 22 fixed to the top port of the feces collecting bin 21, and a square groove 26 inserted into the inner cavity of the feces collecting bin 21, and a filter plate 24 is fixedly connected in the inner cavity of the square groove 26.
[0037] The two groups of mouse restraint fixing brackets 3 each include two columns 31, a support seat 32 fixed on the top of the column 31, and a connecting rod 34 rotatably arranged between the support seats 32, a screw 35 is arranged inside the connecting rod 34, a hollow tube 37 is arranged at the end of the screw 35, an L-shaped support plate 38 is fixed at the bottom end of the hollow tube 37, a movable piece 312 is hinged on the top end of the L-shaped support plate 38, arc-shaped clamping claws 311 are fixed on the bottom ends of the movable piece 312 and the L-shaped support plate 38, and a screw rod 39 is arranged between the movable piece 312 and the L-shaped support plate 38, and an internal threaded sleeve 313 is screwed on the outer ring of the screw rod 39.
[0038] The atomizing drug delivery mechanism 4 includes a small water pump 41 and a medicine box 42 connected by pipelines. The discharge port of the small water pump 41 is connected to a liquid guide tube 46 through a pipe joint. The bottom surface of the liquid guide tube 46 is penetrated by 7-9 manifolds 44 that penetrate into the inner cavity of the observation and recording box 1. Atomizing nozzles 45 are installed on the ends of the manifolds 44 located in the inner cavity of the observation and recording box 1.
[0039] The front and rear side walls of the box body 11 and the box cover 12 are provided with 20-30 ventilation grilles, the bottom end edge of the box body 11 is fixed with a circle of convex strips, and the top end edge of the box cover 12 is provided with a circle of grooves for the convex strips to be inserted into. The left end faces of the box body 11 and the box cover 12 are provided with notches for the hatch 13 to be embedded and placed, the top and bottom of the hatch 13 are fixed with two convex rods, and the left end faces of the box body 11 and the box cover 12 are provided with through holes for the convex rods to be inserted and coupled.
[0040] A circle of circular holes in the shape of an annular ring is provided on the top of the box body 11 for the manifold 44 to pass through, and a sealing ring that matches the outer ring of the manifold 44 is filled inside the circular holes. An opening is provided on the bottom end face of the box cover 12, and the outer surface of the hollow partition 22 is fixed in the inner cavity of the opening; a square through hole is provided on the rear end face of the feces collection bin 21 for the square groove 26 to be inserted and slide forward and backward, and a support bar 23 is fixedly connected to the left and right side walls of the inner cavity of the feces collection bin 21, and the left and right sides of the bottom end surface of the square groove 26 are in sliding contact with the top surface of the support bar 23 respectively.
[0041] A plurality of through holes are provided in the hollow partition 22 for the passage of mouse feces and urine, and the top end surface of the hollow partition 22 is flush with the bottom surface of the inner cavity of the box body 11; a plurality of filter holes are provided in the filter plate 24 for filtering feces and allowing urine to flow downward, and the filter plate 24 divides the inner cavity space of the square groove 26 into two parts, the upper inner cavity space of the square groove 26 is used to carry feces, and the lower inner cavity space of the square groove 26 is used to collect mouse urine. A pull-out handle 25 is fixedly connected to the rear end surface of the square groove 26 by screws.
[0042] The bottom ends of the columns 31 are fixedly connected to the top surface of the hollow partition 22. A servo motor 33 is installed on the side wall of the rear support seat 32. The output shaft of the servo motor 33 is fixedly connected to one end of the connecting rod 34. The other end of the connecting rod 34 is rotatably connected to the side wall of the front servo motor 33. The inner cavity of the connecting rod 34 is provided with a plurality of through holes arranged at equal distances. The screw 35 passes through the through holes and nuts are screwed on the sections where the screw 35 is located outside the through holes. A round hole for the screw 35 to pass through is provided inside the hollow tube 37. A locking screw 36 is penetrated at the top of the hollow tube 37. The side wall of the screw 35 located in the inner cavity of the hollow tube 37 is in close contact with the bottom end of the locking screw 36.
[0043] The L-shaped support plate 38 and the movable sheet 312 are both provided with openings for the screw rod 39 to pass through, the front end of the screw rod 39 is fixed with a stop block having a diameter larger than the opening, the section of the screw rod 39 away from the stop block is provided with a thread, the inner cavity of the internal threaded sleeve 313 is provided with a screw thread adapted to the outer thread of the screw rod 39, the end face of the internal threaded sleeve 313 close to the L-shaped support plate 38 is in close contact with the outer side wall of 213, the side wall of the L-shaped support plate 38 and the movable sheet 312 close to each other is fixed with a cylindrical spring 310 sleeved on the outer ring of the screw rod 39, the arc-shaped clamping claws 311 are all arc-shaped and the side of the arc-shaped clamping claws 311 close to each other is in contact with the body of the mouse. The bottom surface of the medicine box 42 is fixedly connected to the top surface of the box cover 12, the liquid extraction port of the small water pump 41 is connected to the liquid extraction pipeline 43 that runs through the inner cavity of the medicine box 42, and the liquid guide tube 46 is in the shape of a "mouth" as a whole.
[0044] Embodiment 2: According to the preferred technical solution in Embodiment 1, there is the following practical use process:
[0045] For the assembly and use of the observation and recording box 1, mice are put between the box body 11 and the box cover 12, and appropriate amounts of food and water are placed inside the observation and recording box 1. The convex strips and grooves between the box body 11 and the box cover 12 are mutually coupled by snapping. Before that, the two protruding rods at the bottom of the hatch 13 are inserted into the through holes on the left end face of the box body 11. After the box cover 12 is closed, the two protruding rods at the top of the hatch 13 are inserted into the through holes on the left end face of the box cover 12, thereby forming a sealed space. At the same time, the top middle area of the box cover 12 has a downwardly concave groove, and various data are filled in on a card or paper and attached to the groove. The card or paper has information such as the weight of the mouse, the test drug, etc.
[0046] After the experimental drug is injected into the medicine box 42 through the injection port on the top of the medicine box 42, the internal photoelectric liquid level sensor of the medicine box 42 will detect the liquid level of the drug. The small water pump 41 transports the drug to the liquid guide tube 46 through the liquid extraction pipeline 43. Since the liquid guide tube 46 is in the shape of a square, and the manifold 44 below the liquid guide tube 46 is located between the box body 11 and the box cover 12, the drug is transported to the inside of the atomizing nozzle 45 through the guidance of the manifold 44. Under the atomization effect of the atomizing nozzle 45, the drug diffuses between the box body 11 and the box cover 12, thereby achieving drug administration to the mice.
[0047] After the mice are dosed, the mice can be allowed to move inside the observation and recording box 1 in the early stage. After the mice eat and drink water, their excrement will enter the square groove 26 through the holes on the hollow partition 22. At this time, the granular solid feces are blocked by the filter plate 24 and remain in the upper layer, while the urine enters the lower layer of the inner cavity of the square groove 26. After the square groove 26 is pulled out by pulling the handle 25, the changes in the mouse excrement after the drug administration can be obtained.
[0048] After the mouse has been active for a while, the operator catches the mouse by opening the hatch 13 and places the mouse's body between the two sets of arc-shaped jaws 311. The operator drives the L-shaped support plate 38 and the movable plate 312 closer to each other by screwing the internal threaded sleeve 313, and then brings the arc-shaped jaws 311 closer to each other to clamp the front and rear parts of the mouse's body. On the basis of restricting the mouse's activity, muscle electrodes and EEG electrodes are respectively attached to the mouse's body to detect physical changes in the mouse after drug administration.
[0049] The present invention is not limited to the above-mentioned optimal implementation mode. Anyone should be aware that any structural changes made under the inspiration of the present invention, and any technical solutions that are the same or similar to the present invention, fall within the protection scope of the present invention. Finally, it should be noted that the structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the restrictive conditions that can be implemented in this application, so they have no technical substantive significance. Any structural modification, change in proportional relationship or adjustment of size, without affecting the effects that can be produced by this application and the purposes that can be achieved, should still fall within the scope that can be covered by the technical content disclosed in this application.
Claims
1. A mouse observation and recording device for drug testing, comprising an observation and recording box (1), characterized in that: An atomizing drug delivery mechanism (4) is arranged on the right side of the top surface of the observation and recording box (1), two groups of mouse restraint fixing brackets (3) are fixedly connected in the inner cavity of the observation and recording box (1), and a mouse feces collection and recording mechanism (2) is arranged on the bottom surface of the observation and recording box (1); The observation and recording box (1) comprises a box body (11), a box cover (12) which is buckled and connected to an upper end of the box body (11), and a hatch (13) which is connected to the left side space between the box body (11) and the box cover (12); The mouse feces collection and recording mechanism (2) comprises a feces collection chamber (21), a hollow partition plate (22) fixed to the top port of the feces collection chamber (21), and a square groove (26) inserted into the inner cavity of the feces collection chamber (21), wherein a filter plate (24) is fixedly connected to the inner cavity of the square groove (26); The two groups of mouse restraint fixing brackets (3) each include two upright posts (31), a support seat (32) fixed at the top of the upright post (31), and a connecting rod (34) rotatably arranged between the supporting seats (32), a screw rod (35) passing through the interior of the connecting rod (34), a hollow tube (37) being arranged at the end of the screw rod (35), an L-shaped supporting plate (38) being fixed at the bottom end of the hollow tube (37), a movable sheet (312) being hingedly connected to the top end of the L-shaped supporting plate (38), arc-shaped clamping claws (311) being fixed at the bottom ends of the movable sheet (312) and the L-shaped supporting plate (38), and a screw rod (39) passing through the movable sheet (312) and the L-shaped supporting plate (38), an internally threaded sleeve (313) being screwed on the outer ring of the screw rod (39); The atomizing drug delivery mechanism (4) comprises a small water pump (41) and a medicine box (42) connected by a pipeline. The discharge port of the small water pump (41) is connected to a liquid guide tube (46) through a pipe joint. The bottom surface of the liquid guide tube (46) is penetrated by 7 to 9 manifolds (44) that penetrate into the inner cavity of the observation and recording box (1). The ends of the manifolds (44) located in the inner cavity of the observation and recording box (1) are all equipped with atomizing nozzles (45).
2. A drug testing mouse observation and recording device according to claim 1, characterized in that: The front and rear side walls of the box body (11) and the box cover (12) are both provided with 20-30 ventilation grilles, a circle of convex strips are fixed on the edge of the bottom end surface of the box body (11), and a circle of grooves for the convex strips to be inserted into are provided on the edge of the top end surface of the box cover (12).
3. A drug testing mouse observation and recording device according to claim 1, characterized in that: The left end surfaces of the box body (11) and the box cover (12) are both provided with notches for the hatch door (13) to be embedded and placed, the top and bottom of the hatch door (13) are both fixed with two protruding rods, and the left end surfaces of the box body (11) and the box cover (12) are both provided with through holes for the protruding rods to be inserted and coupled.
4. A drug testing mouse observation and recording device according to claim 1, characterized in that: The top of the box body (11) is provided with a circle of circular holes for the manifold (44) to pass through, and the interior of the circular holes is filled with a sealing ring that matches the outer ring of the manifold (44). The bottom end face of the box cover (12) is provided with an opening, and the outer surface of the hollow partition (22) is fixed in the inner cavity of the opening.
5. The drug testing mouse observation and recording device according to claim 1, characterized in that: A square through hole is provided on the rear end surface of the feces collection bin (21) for the square groove (26) to be inserted and slid forward and backward, and a support bar (23) is fixedly connected to the left and right side walls of the inner cavity of the feces collection bin (21), and the left and right sides of the bottom end surface of the square groove (26) are in sliding contact with the top surface of the support bar (23) respectively.
6. A drug testing mouse observation and recording device according to claim 1, characterized in that: The hollow partition (22) is provided with a plurality of through holes for mouse feces and urine to pass through, and the top end surface of the hollow partition (22) is flush with the bottom surface of the inner cavity of the box body (11); the filter plate (24) is provided with a plurality of filter holes for filtering feces and allowing urine to flow downward, and the filter plate (24) divides the inner cavity space of the square groove (26) into upper and lower parts, the upper inner cavity space of the square groove (26) is used to carry feces, and the lower inner cavity space of the square groove (26) is used to collect mouse urine, and a pull-out handle (25) is fixedly connected to the rear end surface of the square groove (26) by screws.
7. The drug testing mouse observation and recording device according to claim 1, characterized in that: The bottom ends of the columns (31) are fixedly connected to the top surface of the hollow partition (22), a servo motor (33) is installed on the side wall of the rear support seat (32), the output shaft of the servo motor (33) is fixedly connected to one end of the connecting rod (34), the other end of the connecting rod (34) is rotatably connected to the side wall of the servo motor (33) on the front side, a plurality of through holes arranged at equal distances are opened in the inner cavity of the connecting rod (34), the screw rod (35) passes through the through hole and nuts are screwed on the sections of the screw rod (35) located outside the through hole.
8. The drug testing mouse observation and recording device according to claim 1, characterized in that: The hollow tube (37) has a circular hole inside for the screw (35) to pass through, and a locking screw (36) passes through the top of the hollow tube (37). The side wall of the screw (35) located in the inner cavity of the hollow tube (37) is in close contact with the bottom end of the locking screw (36).
9. The drug testing mouse observation and recording device according to claim 1, characterized in that: The L-shaped support plate (38) and the movable plate (312) are both provided with openings for the screw rod (39) to pass through, a limit block having a diameter larger than the opening is fixed at the front end of the screw rod (39), a thread is provided on the section of the screw rod (39) away from the limit block, a screw thread is provided in the inner cavity of the internal threaded sleeve (313) with a screw thread adapted to the outer circle thread of the screw rod (39), an end face of the internal threaded sleeve (313) close to the L-shaped support plate (38) is in close contact with the outer side wall of (213), a cylindrical spring (310) sleeved on the outer circle of the screw rod (39) is fixed on the side walls close to each other of the L-shaped support plate (38) and the movable plate (312), and the arc-shaped clamping claws (311) are both arc-shaped and the side of the arc-shaped clamping claws (311) close to each other is in contact with the body of the mouse.
10. The drug testing mouse observation and recording device according to claim 1, characterized in that: The bottom surface of the medicine box (42) is fixedly connected to the top surface of the box cover (12), the liquid extraction port of the small water pump (41) is connected to a liquid extraction pipeline (43) that penetrates into the inner cavity of the medicine box (42), and the liquid guide tube (46) is in the shape of a "mouth" as a whole.