Nutritional meal replacement dietary preparation for various metabolic weight loss patients and preparation method of nutritional meal replacement dietary preparation

Abstract

The invention discloses a nutritional meal replacement dietary preparation for various metabolic weight loss patients and a preparation method of the nutritional meal replacement dietary preparation, and relates to the technical field of nutritional supplements. The preparation comprises nutritional ingredients and regulating ingredients, wherein the nutritional ingredients comprise protein, fat, carbohydrate, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamin A, vitamin B1, vitamin B2, vitamin B3, pantothenic acid, vitamin B6, biotin, folic acid, vitamin B12, vitamin C, vitamin D3, vitamin E and peptides; the adjusting components comprise Chinese yam powder, radix puerariae powder, creatine, L-carnitine-L-tartrate, glutamine and L-leucine; and the GI of the nutritional meal replacement dietary preparation is less than or equal to 40. The preparation disclosed by the invention can meet the multi-nutrient requirements of patients suffering from weight loss, can play roles in assisting in controlling blood sugar and blood fat, enhancing immunity and improving intestinal functions, and also can play an effect of supporting fat burning and weight management.

Description

Technical Field

[0001] The present invention relates to the technical field of nutritional supplements, and in particular to a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss conditions and a preparation method thereof. Background Art

[0002] Obesity not only affects the quality of life, but also increases the risk of complications such as cardiovascular disease and chronic kidney disease. The incidence of obesity-related diseases such as metabolic syndrome and type 2 diabetes has increased significantly. In related technologies, weight loss can be achieved through weight loss surgery, dieting, and weight loss drugs. As an effective means of treating severe obesity, weight loss surgery helps patients control their food intake and change their eating habits by reducing stomach capacity or changing the structure of the digestive system, thereby achieving the goal of weight loss.

[0003] Whether it is weight loss surgery or other weight loss methods, nutritional deficiencies will occur while reducing intake; especially for people who lose weight after surgery, most postoperative patients will face the risk of nutrient deficiency. Postoperative patients face the risk of nutrient deficiency because of two reasons: first, the patient's food intake is reduced and nutrient intake is insufficient; second, surgery changes the anatomical structure and physiological function of the digestive system, affecting the digestion and absorption of nutrients, especially gastric bypass surgery, where food does not pass through the duodenum and upper jejunum, resulting in insufficient absorption of nutrients such as fat-soluble vitamins, vitamin B12, and iron. Therefore, nutritional management of patients after weight loss surgery is particularly important.

[0004] At present, patients after weight loss surgery mainly take common vitamin and mineral supplements orally to prevent nutritional deficiencies. However, since the composition, content, and dosage form of common vitamins do not take into account the special physiological conditions of patients, nor the different metabolic conditions of weight loss patients, it is difficult to effectively meet the special nutritional needs of patients with different metabolisms. Therefore, it is urgent to develop a nutritional meal replacement dietary preparation for patients with multiple metabolisms to meet the special nutritional needs of patients undergoing weight loss surgery. Summary of the invention

[0005] The present invention discloses a nutritional meal replacement dietary preparation for patients with various metabolic weight loss conditions and a preparation method thereof, so as to solve the technical problem in the related art that vitamin and mineral supplements are difficult to meet the nutritional needs of patients with different metabolic weight loss conditions.

[0006] In order to solve the above problems, the present invention adopts the following technical solutions: The first aspect of the present invention discloses a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss conditions.

[0007] The present invention discloses a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss, comprising nutritional ingredients and regulating ingredients, wherein the nutritional ingredients include protein, fat, carbohydrate, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamin A, vitamin B1, vitamin B2, vitamin B3, pantothenic acid, vitamin B6, biotin, folic acid, vitamin B12, vitamin C, vitamin D3, vitamin E, and peptides; the regulating ingredients include yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine; and the GI of the nutritional meal replacement dietary preparation is ≤40.

[0008] According to an optional embodiment, the nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss also includes auxiliary materials, which are one or more of adhesives, lubricants, sweeteners, flavoring agents, thickeners, and disintegrants.

[0009] According to an optional embodiment, the nutritional meal replacement dietary preparation is a liquid preparation, a semi-liquid preparation and / or a solid preparation.

[0010] According to an optional embodiment, the nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss includes the following components: 10-30 grams of protein, 4-9 grams of fat, 20-40 grams of carbohydrates, 3-5 grams of dietary fiber, 0.2-0.3 grams of sodium, 0.3-0.35 grams of potassium, 0.3-0.35 grams of calcium, 0.25-0.3 grams of phosphorus, 7-8 milligrams of iron, 4-5 milligrams of zinc, 15-20 micrograms of selenium, 180-200 micrograms of vitamin A, 0.5-1 milligram of vitamin B1, 0.5-1 milligram of vitamin B1, grams of vitamin B2, 10-15 mg of vitamin B3, 2-5 mg of pantothenic acid, 1-2 mg of vitamin B6, 20-40 micrograms of biotin, 100-120 micrograms of folic acid, 1-2 micrograms of vitamin B12, 30-50 mg of vitamin C, 5-8 micrograms of vitamin D3, 6-8 mg of vitamin E, 3-5 grams of peptides, 3.5-9 grams of yam powder, 3.0-9 grams of kudzu powder, 2-4 grams of creatine, 1-3 grams of L-carnitine-L-tartrate, 0.5-2 grams of glutamine, and 0.3-0.5 grams of L-leucine.

[0011] According to an optional embodiment, the nutritional meal replacement dietary preparation is used for patients who lose weight after surgery, and the nutritional meal replacement dietary preparation includes the following components: 30 grams of protein, 4.8 grams of fat, 20 grams of carbohydrates, 3.9 grams of dietary fiber, 0.28 grams of sodium, 0.3 grams of potassium, 0.32 grams of calcium, 0.3 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1 , 0.8 mg vitamin B2, 14.5 mg vitamin B3, 3 mg pantothenic acid, 1.2 mg vitamin B6, 30 mcg biotin, 110 mcg folic acid, 1.5 mcg vitamin B12, 40 mg vitamin C, 6 mcg vitamin D3, 7 mg vitamin E, 3.3 g peptides, 3.5 g yam powder, 3.4 g kudzu powder, 3 g creatine, 2 g L-carnitine-L-tartrate, 1 g glutamine, 0.49 g L-leucine.

[0012] According to an optional embodiment, the nutritional meal replacement dietary preparation is used for non-surgical weight loss patients, and the nutritional meal replacement dietary preparation includes the following components: 20 grams of protein, 8 grams of fat, 40 grams of carbohydrates, 4.5 grams of dietary fiber, 0.28 grams of sodium, 0.35 grams of potassium, 0.32 grams of calcium, 0.3 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1 , 0.8 mg vitamin B2, 14.5 mg vitamin B3, 3 mg pantothenic acid, 1.2 mg vitamin B6, 30 mcg biotin, 110 mcg folic acid, 1.5 mcg vitamin B12, 40 mg vitamin C, 6 mcg vitamin D3, 7 mg vitamin E, 3.3 g peptides, 4.9 g yam powder, 4.8 g kudzu powder, 3 g creatine, 2 g L-carnitine-L-tartrate, 1 g glutamine, 0.49 g L-leucine.

[0013] According to an optional embodiment, the nutritional meal replacement dietary preparation is used for patients with kidney disease who are losing weight, and the nutritional meal replacement dietary preparation includes the following components: 10 grams of protein, 9 grams of fat, 40 grams of carbohydrates, 4.5 grams of dietary fiber, 0.207 grams of sodium, 0.3 grams of potassium, 0.32 grams of calcium, 0.26 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1 , 0.8 mg vitamin B2, 14.5 mg vitamin B3, 3 mg pantothenic acid, 1.2 mg vitamin B6, 30 mcg biotin, 110 mcg folic acid, 1.5 mcg vitamin B12, 40 mg vitamin C, 6 mcg vitamin D3, 7 mg vitamin E, 3.3 g peptides, 8.9 g yam powder, 8.9 g kudzu powder, 3 g creatine, 2 g L-carnitine-L-tartrate, 1 g glutamine, 0.49 g L-leucine.

[0014] The second aspect of the present invention discloses a method for preparing a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss conditions.

[0015] The method for preparing a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to any one of the technical solutions of the present invention comprises the following steps: Step 100: taking multiple types of proteins, fats, carbohydrates, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamins, pantothenic acid, biotin, folic acid, and peptides according to a proportion, and mixing them to obtain a first mixture; Step 200: taking one or more of yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine according to a proportion, adding the mixture to the first mixture, and mixing to obtain a second mixture; Step 300: Mix and stir the second mixture with auxiliary materials to prepare a liquid preparation, a semi-liquid preparation or a solid preparation.

[0016] According to an optional embodiment, the ratio of multiple proteins, fats, carbohydrates, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamins, pantothenic acid, biotin, folic acid, peptides, and one or more of yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine is determined based on the metabolic type of the weight loss patient.

[0017] The technical solution adopted by the present invention can achieve the following beneficial effects: In the first aspect, the present invention provides a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss, including protein, fat, carbohydrates, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamin A, vitamin B1, vitamin B2, vitamin B3, pantothenic acid, vitamin B6, biotin, folic acid, vitamin B12, vitamin C, vitamin D3, vitamin E, and peptides. It is rich in vitamins and mineral elements and is added with nutritional elements urgently needed by patients with weight loss, such as iron, calcium, vitamin A, vitamin B1, vitamin B12, etc. It can meet the multiple nutritional needs of patients with weight loss, maintain the vitamins and minerals needed by the human body, help reduce the risk of anemia and osteoporosis in patients with weight loss, and solve the problem that the existing ordinary vitamin and mineral supplements have a single ingredient and a limited supplement effect.

[0018] Secondly, the present invention is a nutritional meal replacement dietary preparation for various metabolic weight loss patients. The regulating ingredients include yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine. The nutritional meal replacement dietary preparation has a GI of ≤40, which is not only beneficial for reducing postprandial blood sugar fluctuations and suitable for diabetic patients and people with a high incidence of metabolic syndrome, but also can assist in controlling blood sugar, enhancing immunity and improving intestinal function, and can also assist in regulating blood lipids and endocrine system, and can also promote rapid recovery of weight loss patients, support fat burning and weight management, solving the technical problem in the related art that vitamin and mineral supplements are difficult to meet the nutritional needs of different metabolic weight loss patients. DETAILED DESCRIPTION

[0019] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0020] The terms "first", "second", etc. in the specification and claims of this application are used to distinguish similar objects, and are not used to describe a specific order or sequence. It should be understood that the data used in this way can be interchangeable under appropriate circumstances, so that the embodiments of the present application can be implemented in an order other than those described here, and the objects distinguished by "first", "second", etc. are generally of one type, and the number of objects is not limited. For example, the first object can be one or more. In addition, "and / or" in the specification and claims represents at least one of the connected objects, and the character " / " generally indicates that the objects associated before and after are in an "or" relationship.

[0021] The present application is used for a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss, including nutritional ingredients and regulating ingredients. The nutritional ingredients include protein, fat, carbohydrates, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamin A, vitamin B1, vitamin B2, vitamin B3, pantothenic acid, vitamin B6, biotin, folic acid, vitamin B12, vitamin C, vitamin D3, vitamin E, and peptides. The regulating ingredients include yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine. The GI of the nutritional meal replacement dietary preparation is ≤40.

[0022] Preferably, the nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss also includes excipients. The excipients are one or more of a binder, a lubricant, a sweetener, a flavoring agent, a thickener, and a disintegrant. By adding an appropriate amount of pharmaceutical excipients, it is beneficial to the preparation production and processing and / or improve the taste of the preparation.

[0023] Preferably, the nutritional meal replacement dietary preparation is a liquid preparation, a semi-liquid preparation and / or a solid preparation. The nutritional meal replacement dietary preparation of the present application can be made into a liquid preparation, a semi-liquid preparation and a solid preparation, and can be selected based on the type of weight loss patient to ensure the smoothness of the diet transition and the comprehensiveness of nutritional supplementation for the weight loss patient. Exemplarily, for postoperative weight loss patients, liquid preparations are selected in the first month after surgery to ensure nutrient absorption while reducing gastrointestinal burden; semi-liquid preparations can be selected 1 to 3 months after surgery to promote intestinal function recovery; solid preparations are selected 3 months after surgery to ensure long-term nutritional supplementation and weight management.

[0024] The present application is used for a nutritious meal replacement dietary preparation for patients with multiple metabolic weight loss, including protein, fat, carbohydrates, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamin A, vitamin B1, vitamin B2, vitamin B3, pantothenic acid, vitamin B6, biotin, folic acid, vitamin B12, vitamin C, vitamin D3, vitamin E, and peptides. The preparation is rich in vitamins and mineral elements and is supplemented with nutrients urgently needed by patients with weight loss, such as iron, calcium, vitamin A, vitamin B1, vitamin B12, etc. The preparation can meet the multiple nutritional needs of patients with weight loss, maintain the vitamins and minerals needed by the human body, help reduce the risk of anemia and osteoporosis in patients with weight loss, and solve the problem that existing ordinary vitamin and mineral supplements have a single ingredient and limited supplement effect.

[0025] The present application is used for a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss, which is added with yam powder and kudzu root powder. The yam powder is selected from the tubers of Dioscorea plants, and its active ingredients include polysaccharides (≥15%), mucin (≥5%), and diosgenin (≥1.2%), which can synergistically regulate postprandial blood sugar (GI value ≤35), enhance intestinal barrier function and postoperative immunity; kudzu root powder is selected from the leguminous plant kudzu root, and its active ingredients include puerarin (≥8%) and soybean glycoside (≥3%), which can reduce blood sugar peak by inhibiting α-glucosidase activity and improve dyslipidemia (total cholesterol reduction ≥10%); the synergistic effect of yam powder and kudzu root powder can also enhance antioxidant capacity (SOD activity increased by 30%) and reduce postoperative oxidative stress damage. It can be seen that the present application is used for a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss. Through the low GI design and the synergistic effect of yam powder and kudzu root powder, it can significantly improve the blood sugar stability, nutrient absorption and long-term health management effects of patients with metabolic abnormalities.

[0026] On the other hand, the present application is for a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss, which is added with yam powder. The mucus protein in the yam powder can also repair the intestinal mucosa and reduce the incidence of diarrhea caused by intestinal flora disorders in postoperative patients (clinical trials show that the incidence of diarrhea has dropped from 18% to 5%); the present application is for a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss, which is added with kudzu root powder. The soybean glucoside in the kudzu root powder can regulate the excretion of urinary protein in patients with kidney disease (clinical trials show that the 24-hour urine protein is reduced by 0.5g / day).

[0027] The present application is a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss, and creatine, L-carnitine-L-tartrate, glutamine, and L-leucine are also added. Creatine can enhance muscle strength and endurance, help promote muscle recovery, and reduce fatigue after exercise in patients with weight loss; L-carnitine-L-tartrate helps transport fatty acids into mitochondria for energy production, thereby supporting fat burning and weight management, and can also reduce exercise-induced muscle damage and inflammation, and promote exercise recovery; glutamine is not only an important energy source for immune cells, helps to enhance the function of the immune system, but also has a positive effect on maintaining intestinal barrier function and overall intestinal health; L-leucine not only plays an important role in stimulating muscle protein synthesis and preventing muscle breakdown, but also helps diabetic patients with weight loss regulate blood sugar levels.

[0028] On the other hand, the present application is used for a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss. Through the synergistic effect of creatine and L-leucine, it can enhance muscle strength and endurance and promote rapid physical recovery of patients with weight loss; through the synergistic effect of L-leucine and yam powder, it can further enhance blood sugar regulation for diabetic patients with weight loss, and through the synergistic effect of yam powder and glutamine, it can further enhance intestinal protection for patients with weight loss.

[0029] It can be seen that the nutritional meal replacement dietary preparations for various metabolic weight loss patients in this application also include yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine, and the nutritional meal replacement dietary preparations have a GI of ≤40, which is not only beneficial for reducing postprandial blood sugar fluctuations and suitable for diabetic patients and people with a high incidence of metabolic syndrome, but also can assist in controlling blood sugar, enhancing immunity and improving intestinal function, and can also assist in regulating blood lipids and endocrine system, and can also promote rapid recovery of weight loss patients, support fat burning and weight management, solving the technical problem in the related technology that vitamin and mineral supplements are difficult to meet the nutritional needs of different metabolic weight loss patients.

[0030] Preferably, the present application is used for a variety of nutritional meal replacement dietary preparations for metabolic weight loss patients, and by adjusting the content of each component, it can also meet the nutritional needs of a variety of different metabolic weight loss patients. For example, for postoperative weight loss patients, a high-protein formula is provided; for kidney disease weight loss patients, a low-protein and low-potassium formula is provided.

[0031] Exemplarily, the present application provides a nutritional meal replacement dietary preparation for patients undergoing weight loss after surgery. The nutritional meal replacement dietary preparation includes components in the following proportions: 30 grams of protein, 4.8 grams of fat, 20 grams of carbohydrates, 3.9 grams of dietary fiber, 0.28 grams of sodium, 0.3 grams of potassium, 0.32 grams of calcium, 0.3 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1, 0.8 milligrams of vitamin B2, 14.5 milligrams of vitamin B3, 3 milligrams of pantothenic acid, 1.2 milligrams of vitamin B6, 30 micrograms of biotin, 110 micrograms of folic acid, 1.5 micrograms of vitamin B12, 40 milligrams of vitamin C, 6 micrograms of vitamin D3, 7 milligrams of vitamin E, 3.3 grams of peptides, 3.5 grams of yam powder, 3.4 grams of kudzu root powder, 3 grams of creatine, 2 grams of L-carnitine-L-tartrate, 1 gram of glutamine, and 0.49 grams of L-leucine.

[0032] This formula provides high protein, high dietary fiber and comprehensive vitamins and minerals, which can ensure the nutritional needs of patients undergoing postoperative weight loss and reduce postoperative complications such as anemia and osteoporosis. In addition, through the low GI design and the synergistic effect of regulating ingredients, it can effectively control postprandial blood sugar fluctuations and help patients achieve healthy weight loss.

[0033] Exemplarily, the present application provides a nutritional meal replacement dietary preparation for non-surgical weight loss patients. Non-surgical weight loss patients, for example, are people who use weight loss drugs or people who are on a diet. The nutritional meal replacement dietary preparation is used for non-surgical weight loss patients, and the nutritional meal replacement dietary preparation includes components in the following proportions: 20 grams of protein, 8 grams of fat, 40 grams of carbohydrates, 4.5 grams of dietary fiber, 0.28 grams of sodium, 0.35 grams of potassium, 0.32 grams of calcium, 0.3 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1, 0.8 milligrams of vitamin B2, 14.5 milligrams of vitamin B3, 3 milligrams of pantothenic acid, 1.2 milligrams of vitamin B6, 30 micrograms of biotin, 110 micrograms of folic acid, 1.5 micrograms of vitamin B12, 40 milligrams of vitamin C, 6 micrograms of vitamin D3, 7 milligrams of vitamin E, 3.3 grams of peptides, 4.9 grams of yam powder, 4.8 grams of kudzu root powder, 3 grams of creatine, 2 grams of L-carnitine-L-tartrate, 1 gram of glutamine, and 0.49 grams of L-leucine.

[0034] This formula effectively controls post-meal blood sugar fluctuations through low GI design and the synergistic effect of regulating ingredients, helping diabetic patients achieve healthy weight loss.

[0035] Exemplarily, the present application provides a nutritional meal replacement dietary preparation for kidney disease patients who are losing weight. The nutritional meal replacement dietary preparation comprises components in the following proportions: 10 grams of protein, 9 grams of fat, 40 grams of carbohydrates, 4.5 grams of dietary fiber, 0.207 grams of sodium, 0.3 grams of potassium, 0.32 grams of calcium, 0.26 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1, 0.8 milligrams of vitamin B2, 14.5 milligrams of vitamin B3, 3 milligrams of pantothenic acid, 1.2 milligrams of vitamin B6, 30 micrograms of biotin, 110 micrograms of folic acid, 1.5 micrograms of vitamin B12, 40 milligrams of vitamin C, 6 micrograms of vitamin D3, 7 milligrams of vitamin E, 3.3 grams of peptides, 8.9 grams of yam powder, 8.9 grams of kudzu root powder, 3 grams of creatine, 2 grams of L-carnitine-L-tartrate, 1 gram of glutamine, and 0.49 grams of L-leucine.

[0036] This formula provides a meal replacement formula that is low in potassium, low in phosphorus, and has an appropriate amount of protein to avoid burdening the kidneys while meeting nutritional needs.

[0037] The method for preparing the nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to any technical solution in the present application comprises the following steps: Step 100: taking multiple types of proteins, fats, carbohydrates, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamins, pantothenic acid, biotin, folic acid, and peptides according to a proportion, and mixing them to obtain a first mixture; Step 200: taking one or more of yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine according to a proportion, adding the mixture to the first mixture, and mixing to obtain a second mixture; Step 300: Mix and stir the second mixture with auxiliary materials to prepare a liquid preparation, a semi-liquid preparation or a solid preparation.

[0038] Preferably, the ratio of multiple of protein, fat, carbohydrate, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamins, pantothenic acid, biotin, folic acid, peptides, and one or more of yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine is determined based on the metabolic type of the weight loss patient. Exemplarily, a high-protein formula is provided for postoperative weight loss patients; a low-protein and low-potassium formula is provided for renal weight loss patients. The formulas for postoperative weight loss patients, non-surgical weight loss patients, and renal weight loss patients are not repeated here.

[0039] The following is a detailed description of the nutritional meal replacement dietary preparation for various metabolic weight loss patients of the present application in combination with various embodiments and comparative examples.

[0040] Example 1 The nutritional meal replacement dietary preparation of this embodiment includes components in the following proportions: 20 grams of protein, 8 grams of fat, 40 grams of carbohydrates, 4.5 grams of dietary fiber, 0.28 grams of sodium, 0.35 grams of potassium, 0.32 grams of calcium, 0.3 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1, 0.8 milligrams of vitamin B2, 14.5 milligrams of vitamin B3, 3 milligrams of pantothenic acid, 1.2 milligrams of vitamin B6, 30 micrograms of biotin, 110 micrograms of folic acid, 1.5 micrograms of vitamin B12, 40 milligrams of vitamin C, 6 micrograms of vitamin D3, 7 milligrams of vitamin E, 3.3 grams of peptides, 4.9 grams of yam powder, 4.8 grams of kudzu root powder, 3 grams of creatine, 2 grams of L-carnitine-L-tartrate, 1 gram of glutamine, and 0.49 grams of L-leucine.

[0041] Comparative Example 1 The meal replacement product on the market - Wonder Lab nutritional meal replacement shake, its ingredients include 18 grams of protein, 3 grams of fat, and 32.9 grams of carbohydrates.

[0042] Subjects: 180 patients with type 2 diabetes and obesity were selected. They were randomly divided into two groups, 90 people in each group, respectively, the experimental group 1 using the nutritional meal replacement dietary preparation of Example 1 for intervention, and the control group 1 using the meal replacement product of Comparative Example 1 for intervention, and the intervention period was 12 weeks. Except for the nutritional meal replacement dietary preparations, the other conditions remained the same. After 12 weeks, the bone density, osteoporosis incidence, fasting blood sugar, number of bifidobacteria in the intestine and inflammatory factors of each group of subjects were tested, and the test results are shown in Table 1.

[0043] Table 1 Test results of various indicators of subjects in blank group 1, experimental group 1 and control group 1 Detection indicators Before intervention Experimental Group 1 Control group 1 <![CDATA[Bone density (g / cm 3 ).]]> 0.85±0.10 0.88±0.08 0.82±0.09 Osteoporosis incidence 32% 18% 30% Fasting blood glucose (mmol / L) 7.8±1.5 6.3±0.8 7.2±1.2 Bifidobacterium count (log10 CFU / g) 7.5±0.6 8.8±0.5 7.6±0.7 Inflammatory factor IL-6 (pg / mL) 5.2±1.8 3.1±1.0 4.9±1.6 Muscle rate (%) 33.0±3.8 39.2±3.5 35.1±4.2 From the results in Table 1, it can be seen that the nutritional meal replacement dietary preparation of Example 1 can meet the nutritional needs of patients with weight loss and reduce the risk of osteoporosis; it can also significantly reduce the fasting blood sugar of diabetic patients, increase the number of bifidobacteria in the intestine, and improve the intestinal health of patients with weight loss; the experimental group 1 reduces muscle decomposition and inflammation due to sufficient protein; the control group 1 has persistent inflammation after surgery. p<0.05.

[0044] Example 2 The nutritional meal replacement dietary preparation of this embodiment includes components in the following proportions: 30 grams of protein, 4.8 grams of fat, 20 grams of carbohydrates, 3.9 grams of dietary fiber, 0.28 grams of sodium, 0.3 grams of potassium, 0.32 grams of calcium, 0.3 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1, 0.8 milligrams of vitamin B2, 14.5 milligrams of vitamin B3, 3 milligrams of pantothenic acid, 1.2 milligrams of vitamin B6, 30 micrograms of biotin, 110 micrograms of folic acid, 1.5 micrograms of vitamin B12, 40 milligrams of vitamin C, 6 micrograms of vitamin D3, 7 milligrams of vitamin E, 3.3 grams of peptides, 3.5 grams of yam powder, 3.4 grams of kudzu root powder, 3 grams of creatine, 2 grams of L-carnitine-L-tartrate, 1 gram of glutamine, and 0.49 grams of L-leucine.

[0045] Comparative Example 2 The meal replacement product on the market - Wonder Lab nutritional meal replacement shake, its ingredients include 18 grams of protein, 3 grams of fat, and 32.9 grams of carbohydrates.

[0046] Subjects: 144 adult patients who underwent laparoscopic sleeve gastrectomy and gastric bypass were selected and randomly divided into two groups, 72 people in each group, respectively, the test group 2 using the nutritional meal replacement dietary preparation of Example 2 for intervention, and the control group 2 using the meal replacement product of Comparative Example 2 for intervention, and the intervention period was 12 weeks. Except for the nutritional meal replacement dietary preparations, the other conditions of each group remained the same. After 12 weeks, the serum vitamin levels of the subjects in each group were tested, and the test results are shown in Table 2.

[0047] Table 2 Test results of various indicators of subjects in test group 2 and control group 2 Detection indicators Before intervention Experimental Group 1 Control group 1 Vitamin A (IU / ml) 0.35±0.10 0.42±0.14 0.36±0.09 Vitamin D (ng / ml) 18.5±5.2 32.6±6.7 17.8±4.9 Vitamin E (mg / L) 8.2±2.1 10.5±2.4 9.4±1.6 Vitamin B12 (μg / L) 320±85 450±90 330±80 Folic acid (ng / ml) 6.5±1.8 9.2±2.2 6.8±1.6 From the results in Table 2, it can be seen that the nutritional meal replacement dietary preparation of Example 2 can meet the multiple nutritional needs of weight loss patients and maintain the vitamins and minerals required by the human body. The serum vitamin A, D, E, B12 and folic acid levels of patients in the experimental group 2 are higher than those before the intervention and the control group 1.

[0048] Example 3 The nutritional meal replacement dietary preparation of this embodiment includes components in the following proportions: 10 grams of protein, 9 grams of fat, 40 grams of carbohydrates, 4.5 grams of dietary fiber, 0.207 grams of sodium, 0.3 grams of potassium, 0.32 grams of calcium, 0.26 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1, 0.8 milligrams of vitamin B2, 14.5 milligrams of vitamin B3, 3 milligrams of pantothenic acid, 1.2 milligrams of vitamin B6, 30 micrograms of biotin, 110 micrograms of folic acid, 1.5 micrograms of vitamin B12, 40 milligrams of vitamin C, 6 micrograms of vitamin D3, 7 milligrams of vitamin E, 3.3 grams of peptides, 8.9 grams of yam powder, 8.9 grams of kudzu root powder, 3 grams of creatine, 2 grams of L-carnitine-L-tartrate, 1 gram of glutamine, and 0.49 grams of L-leucine.

[0049] Comparative Example 3 The meal replacement product on the market - Wonder Lab nutritional meal replacement shake, its ingredients include 18 grams of protein, 3 grams of fat, and 32.9 grams of carbohydrates.

[0050] Subjects: 120 patients with kidney disease and obesity were selected and randomly divided into two groups, 60 people in each group, respectively, the test group 3 using the nutritional meal replacement dietary preparation of Example 3 for intervention, and the control group 3 using the meal replacement product of Comparative Example 3 for intervention, and the intervention period was 12 weeks. Except for the nutritional meal replacement dietary preparations, the other conditions of each group remained the same. After 12 weeks, the electrolyte balance, renal function indexes, metabolic parameters and nutritional status of each group of subjects were tested, and the test results are shown in Table 3.

[0051] Table 3 Test results of various indicators of subjects in experimental group 3 and control group 3 Detection indicators Before intervention Experimental Group 3 Control group 3 Serum creatinine (μmol / L) 90±25 85±20 100±30 Urine protein / creatinine ratio (mg / g) 300±150 250±120 350±180 Serum potassium (mmol / L) 4.2±0.5 4.0±0.4 4.5±0.6 Blood sodium (mmol / L) 138±4 140±3 135±5 Blood phosphorus (mmol / L) 1.2±0.3 1.0±0.2 1.3±0.4 Serum albumin (g / L) 35±5 38±4 32±6 From the results in Table 3, it can be seen that after 12 weeks, the indicators of the experimental group 3 were significantly better than those of the control group 3, which showed improved renal function (reduced urine protein), more balanced electrolytes (normalization of blood potassium / blood sodium), improved nutritional status (increased serum albumin), and no aggravation of the metabolic burden of renal disease (better control of blood phosphorus). p<0.05.

[0052] It should be noted that, in this article, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0053] In addition, it should be noted that the scope of the methods and devices in the embodiments of the present application is not limited to performing functions in the order shown or discussed, and may also include performing functions in a substantially simultaneous manner or in a reverse order according to the functions involved. For example, the described methods may be performed in an order different from that described, and various steps may be added, omitted, or combined. In addition, features described with reference to certain examples may be combined in other examples.

[0054] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss, characterized in that: It includes nutritional ingredients and regulating ingredients, wherein the nutritional ingredients include protein, fat, carbohydrates, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamin A, vitamin B1, vitamin B2, vitamin B3, pantothenic acid, vitamin B6, biotin, folic acid, vitamin B12, vitamin C, vitamin D3, vitamin E, and peptides; the regulating ingredients include yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine; and the GI of the nutritional meal replacement dietary preparation is ≤40.

2. The nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to claim 1, characterized in that: The composition further comprises auxiliary materials, which are one or more of a binder, a lubricant, a sweetener, a flavoring agent, a thickener, and a disintegrant.

3. The nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to claim 1, characterized in that: The nutritional meal replacement dietary preparation is a liquid preparation, a semi-liquid preparation and / or a solid preparation.

4. The nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to any one of claims 1 to 3, characterized in that: The ingredients include the following proportions: 10-30 grams of protein, 4-9 grams of fat, 20-40 grams of carbohydrates, 3-5 grams of dietary fiber, 0.2-0.3 grams of sodium, 0.3-0.35 grams of potassium, 0.3-0.35 grams of calcium, 0.25-0.3 grams of phosphorus, 7-8 milligrams of iron, 4-5 milligrams of zinc, 15-20 micrograms of selenium, 180-200 micrograms of vitamin A, 0.5-1 milligram of vitamin B1, 0.5-1 milligram of vitamin B2, 10-15 milligrams of vitamin B3, 2~5 mg pantothenic acid, 1~2 mg vitamin B6, 20~40 micrograms biotin, 100~120 micrograms folic acid, 1~2 micrograms vitamin B12, 30~50 mg vitamin C, 5~8 micrograms vitamin D3, 6~8 mg vitamin E, 3~5 grams peptides, 3.5~9 grams yam powder, 3.0~9 grams kudzu powder, 2~4 grams creatine, 1~3 grams L-carnitine-L-tartrate, 0.5~2 grams glutamine, 0.3~0.5 grams L-leucine.

5. The nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to claim 4, characterized in that: The nutritional meal replacement dietary preparation is used for patients who lose weight after surgery, and the nutritional meal replacement dietary preparation includes components in the following proportions: 30 grams of protein, 4.8 grams of fat, 20 grams of carbohydrates, 3.9 grams of dietary fiber, 0.28 grams of sodium, 0.3 grams of potassium, 0.32 grams of calcium, 0.3 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1, 0.8 milligrams of vitamin B2, 14.5 milligrams of vitamin B3, 3 milligrams of pantothenic acid, 1.2 milligrams of vitamin B6, 30 micrograms of biotin, 110 micrograms of folic acid, 1.5 micrograms of vitamin B12, 40 milligrams of vitamin C, 6 micrograms of vitamin D3, 7 milligrams of vitamin E, 3.3 grams of peptides, 3.5 grams of yam powder, 3.4 grams of kudzu root powder, 3 grams of creatine, 2 grams of L-carnitine-L-tartrate, 1 gram of glutamine, and 0.49 grams of L-leucine.

6. The nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to claim 4, characterized in that: The nutritional meal replacement dietary preparation is used for non-surgical weight loss patients, and the nutritional meal replacement dietary preparation includes components in the following proportions: 20 grams of protein, 8 grams of fat, 40 grams of carbohydrates, 4.5 grams of dietary fiber, 0.28 grams of sodium, 0.35 grams of potassium, 0.32 grams of calcium, 0.3 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1, 0.8 milligrams of vitamin B2, 14.5 milligrams of vitamin B3, 3 milligrams of pantothenic acid, 1.2 milligrams of vitamin B6, 30 micrograms of biotin, 110 micrograms of folic acid, 1.5 micrograms of vitamin B12, 40 milligrams of vitamin C, 6 micrograms of vitamin D3, 7 milligrams of vitamin E, 3.3 grams of peptides, 4.9 grams of yam powder, 4.8 grams of kudzu root powder, 3 grams of creatine, 2 grams of L-carnitine-L-tartrate, 1 gram of glutamine, and 0.49 grams of L-leucine.

7. The nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to claim 4, characterized in that: The nutritional meal replacement dietary preparation is used for patients with kidney disease who are losing weight, and the nutritional meal replacement dietary preparation includes components in the following proportions: 10 grams of protein, 9 grams of fat, 40 grams of carbohydrates, 4.5 grams of dietary fiber, 0.207 grams of sodium, 0.3 grams of potassium, 0.32 grams of calcium, 0.26 grams of phosphorus, 7.2 milligrams of iron, 4.8 milligrams of zinc, 17.5 micrograms of selenium, 187.5 micrograms of vitamin A, 0.6 milligrams of vitamin B1, 0.8 milligrams of vitamin B2, 14.5 milligrams of vitamin B3, 3 milligrams of pantothenic acid, 1.2 milligrams of vitamin B6, 30 micrograms of biotin, 110 micrograms of folic acid, 1.5 micrograms of vitamin B12, 40 milligrams of vitamin C, 6 micrograms of vitamin D3, 7 milligrams of vitamin E, 3.3 grams of peptides, 8.9 grams of yam powder, 8.9 grams of kudzu root powder, 3 grams of creatine, 2 grams of L-carnitine-L-tartrate, 1 gram of glutamine, and 0.49 grams of L-leucine.

8. A method for preparing a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to any one of claims 1 to 7, characterized in that: The steps include: Step 100: taking multiple types of proteins, fats, carbohydrates, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamins, pantothenic acid, biotin, folic acid, and peptides according to a proportion, and mixing them to obtain a first mixture; Step 200: taking one or more of yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine according to a proportion, adding the mixture to the first mixture, and mixing to obtain a second mixture; Step 300: Mix and stir the second mixture with auxiliary materials to prepare a liquid preparation, a semi-liquid preparation or a solid preparation.

9. The method for preparing a nutritional meal replacement dietary preparation for patients with multiple metabolic weight loss according to claim 8, characterized in that: The ratio of protein, fat, carbohydrate, dietary fiber, sodium, potassium, calcium, phosphorus, iron, zinc, selenium, vitamins, pantothenic acid, biotin, folic acid, multiple peptides, and one or more of yam powder, kudzu root powder, creatine, L-carnitine-L-tartrate, glutamine, and L-leucine is determined based on the metabolic type of the weight loss patient.