Sustained-release administration transnasal endoscopic postoperative conformal frontal sinus stent

Abstract

The invention relates to the technical field of medical equipment, and discloses a sustained-release drug delivery transnasal endoscopic postoperative conformal frontal sinus stent which comprises an outer tube, a fixing ring is fixedly connected to the outside of the outer tube, a plurality of connecting tubes are fixedly connected to the inside of the fixing ring, a drug storage tube is fixedly connected to the bottoms of the connecting tubes, and a drug delivery tube is fixedly connected to the drug storage tube. The outer portion of the connecting pipe is fixedly connected with an inner supporting pipe, a plurality of first medicine outlet holes are formed in the inner supporting pipe, the outer portion of the inner supporting pipe is fixedly connected with an outer supporting pipe, and a plurality of second medicine outlet holes are formed in the outer supporting pipe. In the invention, through a multi-stage and refined drug delivery path, the drug is ensured to continuously play a role in the body of a patient, drug concentration fluctuation and adverse reaction possibly caused by one-time large-dose administration are avoided, the safety and effectiveness of drug treatment are improved, and compression and damage to healthy tissues of the patient are reduced.

Description

Technical Field

[0001] The invention relates to the technical field of medical equipment, and in particular to a post-operative conformable frontal sinus stent for sustained-release drug delivery via nasal endoscopy. Background Art

[0002] Frontal sinus stents are also called sinus stents or nasofrontal duct stents. The sinuses are also called paranasal sinuses and paranasal sinuses. They are multiple air-filled bone cavities around the nasal cavity. The mucosa of the sinuses is connected to the nasal mucosa. Therefore, inflammation of the nasal mucosa often affects the sinus mucosa, causing sinusitis. It is currently believed that the main cause of sinusitis is infection in the sinuses due to sinus obstruction caused by various reasons. Among them, nasal polyps are an important cause of sinus obstruction, and the inflammatory stimulation of the sinuses in turn promotes the growth of nasal polyps, forming a vicious circle. For sinusitis, the current treatment methods mainly include nasal administration, endoscopic sinus surgery and other methods; however, due to the obstruction of nasal tissues such as swollen nasal polyps in the diseased sinuses, it is difficult for drugs to reach the lesion site smoothly, so stents are needed for auxiliary treatment.

[0003] After searching, the Chinese patent document with the announcement number CN219743019U discloses a sinus stent delivery device, including a stent delivery mechanism and a stent storage mechanism; the stent delivery mechanism includes a delivery catheter and a push rod arranged inside the delivery catheter; the end of the push rod is evenly distributed with a plurality of flexible hooks along the circumference; the stent storage mechanism is detachably connected to the head end of the delivery catheter; the stent storage mechanism is provided with a positioning protrusion for guiding the flexible hook. The present invention is provided with a stent delivery mechanism and a stent storage mechanism, and medical staff do not need to load the sinus stent into the delivery catheter, which not only reduces the burden on medical staff, but also perfectly solves the problem of forward jumping when the self-expanding stent is released due to the pulling effect of the flexible hook at the end of the push rod, and the stent can be recovered and reset before the stent is fully deployed, which greatly improves the efficiency and accuracy of the operation.

[0004] The sinus stent needs to be placed precisely inside the treatment position when in use. However, the nasal polyps that often exist in the patient's sinuses seriously hinder the drug from reaching the area of ​​action smoothly, affecting the treatment effect. Therefore, in response to the above problems, a sustained-release transnasal endoscopic postoperative conformal frontal sinus stent is proposed to solve the above problems. Summary of the invention

[0005] The object of the present invention is to provide a postoperative conformable frontal sinus stent for sustained-release drug delivery through nasal endoscopic surgery to solve the problems raised in the above-mentioned background technology.

[0006] To achieve the above object, the present invention provides:

[0007] Preferably, a postoperative conformable frontal sinus stent for sustained-release drug delivery via nasal endoscopic surgery comprises an outer tube, the outer portion of the outer tube is fixedly connected to a fixing ring, the inner portion of the fixing ring is fixedly connected to a plurality of connecting tubes, the bottoms of the plurality of connecting tubes are fixedly connected to a drug storage tube, the outer portion of the connecting tube is fixedly connected to an inner support tube, the inner portion of the inner support tube is provided with a plurality of drug outlet holes 1, the outer portion of the inner support tube is fixedly connected to an outer support tube, the inner portion of the outer support tube is provided with a plurality of drug outlet holes 2, and the outer portion of the outer tube is provided with a liquid collecting component and a position limiting component;

[0008] Preferably, the liquid collecting assembly comprises an adjusting ring, the interior of the adjusting ring is slidably connected to the exterior of the outer tube, a cavity and a mounting hole are provided inside the adjusting ring, a connecting tube is detachably connected inside the mounting hole, and the other end of the connecting tube is fixedly connected to the airbag ball;

[0009] Preferably, a push rod is slidably connected to the inside of the medicine storage tube, one end of the push rod is fixedly connected to a piston, and a plurality of rubber blocks are fixedly connected to the inside of the medicine storage tube;

[0010] Preferably, the limiting assembly comprises a plurality of limiting rods, one end of each limiting rod is fixedly connected to the inside of the adjusting ring, and a plurality of limiting grooves are formed on the outside of the outer tube;

[0011] Preferably, the outside of the piston is slidably connected to the inner wall of the medicine storage tube, and the outside of the piston is in contact with the outside of the rubber block;

[0012] Preferably, the outer portion of the limiting rod is slidably connected to the inner wall of the limiting groove, and the outer portion of the outer tube is provided with a threaded groove;

[0013] Preferably, the outer part of the outer tube is rotatably connected to a plurality of rotating support rods, and the other end of the rotating support rod is rotatably connected to the outer part of the outer support tube;

[0014] Preferably, a drug delivery hole is fixedly connected to the interior of the front end of the outer tube, and a cone head is fixedly connected to the top of the outer tube.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] 1. The present invention pushes the push rod to move the piston inside the drug storage tube. When the contact between the piston and the rubber block is blocked, it clearly indicates that a section of drug delivery is completed. Medical staff can accurately control the dosage of the drug pushed each time. The drug enters the inner support tube from the drug storage tube through the connecting tube, and then flows into the outer support tube through a plurality of carefully designed drug outlet holes 1 inside the inner support tube at a suitable flow rate. Finally, it is slowly and evenly released into the patient's body through a plurality of drug outlet holes 2 with relatively small diameters inside the outer support tube. Through the multi-stage and refined drug delivery path, it is ensured that the drug continues to play a role in the patient's body, avoiding drug concentration fluctuations and adverse reactions that may be caused by one-time large-dose administration, and improving the safety and effectiveness of drug treatment.

[0017] 2. The present invention pushes the adjustment ring to move along the threaded groove outside the outer tube, and at the same time the limit rod slides in the limit groove to limit the movement position of the adjustment ring, thereby driving the bottom of the outer support tube to move upward so that it is bent under force. The rotating support rod rotatably connected to the outside of the outer tube will also rotate with the bending of the outer support tube, playing an auxiliary supporting role for the outer support tube. It can adapt to the size and position of nasal polyps of different patients and the specific physiological characteristics of the nasal cavity and frontal sinus, provide personalized support solutions, improve the treatment effect while reducing pressure and damage to the patient's healthy tissues. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0019] Figure 2 It is a schematic diagram of the structure of the outer support tube of the present invention;

[0020] Figure 3 It is a structural schematic diagram of the fixing ring of the present invention;

[0021] Figure 4 for Figure 3 Enlarged view of point A in the middle;

[0022] Figure 5 It is a schematic diagram of the structural disassembly of the rotating support rod of the present invention;

[0023] Figure 6 It is a structural schematic diagram of the adjustment ring of the present invention;

[0024] Figure 7 It is a schematic diagram of the structure of the drug storage tube of the present invention;

[0025] Figure 8 for Figure 7 Enlarged view of point A in the middle.

[0026] Legend:

[0027] 1. Outer tube; 2. Fixed ring; 3. Connecting tube; 4. Drug storage tube; 5. Push rod; 6. Piston; 7. Rubber block; 8. Inner support tube; 9. Drug outlet hole 1; 10. Outer support tube; 11. Drug outlet hole 2; 12. Rotating support rod; 13. Adjusting ring; 14. Cavity; 15. Mounting hole; 16. Connecting tube; 17. Airbag ball; 18. Drug delivery hole; 19. Limit rod; 20. Limit groove; 21. Cone head; 22. Threaded groove. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] Reference Figures 1 to 3 An embodiment of the present invention is a postoperative conformable frontal sinus stent for sustained-release drug delivery through nasal endoscopy, comprising an outer tube 1, which is the basis of the entire stent system. The outer part of the outer tube 1 is fixedly connected with a fixing ring 2, and the inner part of the fixing ring 2 is fixedly connected with a plurality of connecting tubes 3. The main function of the fixing ring 2 is to provide a stable connection basis for the plurality of connecting tubes 3.

[0030] The bottom of the multiple connecting tubes 3 is fixedly connected with a drug storage tube 4. The drug storage tube 4 is a container for storing drugs and is made of transparent medical-grade plastic, which is convenient for medical staff to observe the remaining amount of the internal drugs at any time. The inside of the drug storage tube 4 is slidably connected with a push rod 5, which is convenient for medical staff to operate. One end of the push rod 5 is fixedly connected with a piston 6, and the piston 6 is made of a medical rubber material with good elasticity and sealing. The outside of the piston 6 is slidably connected to the inner wall of the drug storage tube 4. The piston 6 can fit tightly with the inner wall of the drug storage tube 4 while ensuring smooth sliding under the push of the push rod 5. The piston 6 fits more closely with the inner wall of the drug storage tube 4, effectively preventing the drug from leaking from the gap between the piston 6 and the tube wall during the pushing process, ensuring that all the drugs can be pushed into the connecting tube 3.

[0031] Reference Figures 4 to 5 A plurality of rubber blocks 7 are fixedly connected to the inside of the medicine storage tube 4. When the piston 6 moves along the inner wall of the medicine storage tube 4 under the push of the push rod 5, the rubber block 7 plays a role of positioning and indicating. The outside of the piston 6 contacts the outside of the rubber block 7. When the piston 6 contacts the outside of the rubber block 7, due to the elastic resistance of the rubber block 7, the medical staff can clearly feel that the movement of the push rod 5 is blocked, which means that a section of drug delivery is completed, thereby accurately controlling the delivery dose of the drug.

[0032] The outside of the connecting tube 3 is fixedly connected with the inner support tube 8, which has good supporting capacity and can ensure that it will not be deformed due to external pressure during drug delivery, thereby ensuring the stability of drug delivery. The connecting tube 3 plays a key role as a bridge connecting the drug storage tube 4 and the inner support tube 8, ensuring that the drug can be smoothly delivered from the drug storage tube 4 to the inner support tube 8, and ensuring that the drug will not leak during the delivery process.

[0033] The inner support tube 8 is provided with a plurality of drug outlet holes 9, which can flow out of the inner support tube 8 at an appropriate speed, and can prevent the drug from flowing too fast and causing excessive impact on the internal tissues of the nasal cavity and frontal sinus. The outer support tube 8 is fixedly connected to the outer part of the inner support tube 8. The outer support tube 10 has certain flexibility and elasticity, and can be conformally adjusted according to the physiological structure of the patient's nasal cavity and frontal sinus. The outer support tube 10 is provided with a plurality of drug outlet holes 11, and the diameter of the drug outlet holes 11 is relatively small, which can realize the slow and uniform release of the drug. The smaller diameter of the drug outlet holes 11 can also prevent the drug from flowing out too fast, thereby ensuring that the drug can continue to play a role in the patient's body.

[0034] Reference Figures 6 to 8 The outside of the outer tube 1 is rotatably connected to a plurality of rotating support rods 12, and the other end of the rotating support rod 12 is rotatably connected to the outside of the outer support tube 10. When the outer support tube 10 is bent by force, the rotating support rod 12 will also rotate along with the bending of the outer support tube 10, thereby providing auxiliary support to the outer support tube 10 and enhancing the stability and reliability of the outer support tube 10 when opening the nasal polyps.

[0035] A liquid collecting component is arranged on the outside of the outer tube 1, and the liquid collecting component includes an adjusting ring 13. The adjusting ring 13 is the key to controlling the bending degree of the outer support tube 10. The inside of the adjusting ring 13 is slidably connected to the outside of the outer tube 1. When the adjusting ring 13 drives the bottom of the outer support tube 10 to move upward, the outer support tube 10 is bent by force, so that the nasal polyps inside the patient can be expanded according to the patient's usage.

[0036] A cavity 14 is provided inside the adjusting ring 13, and the inner wall of the cavity 14 is smoothed to reduce the resistance of the gas during the flow and improve the liquid absorption efficiency. A mounting hole 15 is provided inside the adjusting ring 13, and a connecting pipe 16 is detachably connected to the mounting hole 15. The mounting hole 15 ensures that the connecting pipe 16 can be tightly fixed on the adjusting ring 13 after installation without loosening or leakage.

[0037] The cavity 14 can ensure that when it cooperates with the airbag ball 17 through the connecting tube 16, a pressure difference can be effectively formed, which can not only suck out the excess liquid medicine inside the inner support tube 8 and the outer support tube 10, but also will not make the overall structure of the adjustment ring 13 too complicated or affect its use function due to the excessive volume. The other end of the connecting tube 16 is fixedly connected to the airbag ball 17. When the connecting tube 16 presses the airbag ball 17, it can generate sufficient gas flow to transport gas to the inside of the cavity 14, thereby forming an effective pressure difference and realizing the liquid absorption function.

[0038] When the balloon 17 is pressed, the gas inside the balloon 17 is pressed into the cavity 14 through the connecting tube 16; when the pressure is released, the balloon 17 is reset to suck out the air inside the cavity 14, so that pressure is formed inside the cavity 14, and the excess liquid medicine inside the inner support tube 8 and the outer support tube 10 can be sucked out. The front end of the outer tube 1 is fixedly connected with a drug delivery hole 18, which can ensure that the drug can be smoothly injected into the drug storage tube 4 and prevent drug leakage during the injection process. The top of the outer tube 1 is fixedly connected with a cone head 21, which is in the shape of a sharp cone, so that the outer tube 1 is easier to enter the patient's nasal cavity and frontal sinus, which can effectively reduce damage to the nasal mucosa and tissue.

[0039] A limiting assembly is arranged on the outside of the outer tube 1, and the limiting assembly includes a plurality of limiting rods 19, one end of which is fixedly connected to the inside of the adjusting ring 13, and a thread groove 22 is arranged on the outside of the outer tube 1. The main function of the limiting rod 19 is to limit the moving position of the adjusting ring 13 to ensure that the adjusting ring 13 will not move excessively or deviate when moving along the thread groove 22, thereby accurately controlling the bending degree of the outer support tube 10 and ensuring that the bracket can work safely and effectively.

[0040] The thread groove 22 can ensure that the adjusting ring 13 can stably and smoothly move along the outer tube 1 when being pushed by force, and can also provide sufficient friction to prevent the adjusting ring 13 from being displaced when it is not necessary to move. A plurality of limit grooves 20 are provided on the outside of the outer tube 1, and the outside of the limit rod 19 is slidably connected to the inner wall of the limit groove 20. The shape and size of the limit groove 20 match the limit rod 19, ensuring that the limit rod 19 can slide smoothly in the limit groove 20, while effectively restraining the movement of the limit rod 19.

[0041] Working principle: First, inject the drug into the drug storage tube 4 through the drug administration hole 18, then send the outer tube 1 to the treatment position, and then push the adjustment ring 13. The adjustment ring 13 is forced to move along the outside of the thread groove 22. At the same time, the limit rod 19 slides along the inner wall of the limit groove 20, which can limit the moving position of the adjustment ring 13. Therefore, the bottom of the outer support tube 10 can be driven to move upward through the adjustment ring 13. The outer support tube 10 is forced to bend. At this time, the rotating support rod 12 will also rotate with the bending of the outer support tube 10, which can be applied to the outer support tube 1 0 produces auxiliary support, and at the same time can expand the patient's internal nasal polyps according to the patient's usage, and then push the push rod 5. When the push rod 5 moves, it will push the piston 6 to move inside the drug storage tube 4, and can push the drug upward to the inside of the connecting tube 3. When the piston 6 contacts the outside of the rubber block 7, the movement is blocked, indicating that a section of drug delivery is completed. The drug flows into the inside of the inner support tube 8 through the connecting tube 3, and then flows to the inside of the outer support tube 10 through the drug outlet hole 1 9, and the drug is slowly released and output, and finally flows evenly into the patient's interior through the drug outlet hole 2 11.

[0042] After the medicine enters the interior, a small amount of excess liquid medicine will remain inside the inner support tube 8 and the outer support tube 10. At this time, the airbag ball 17 is pressed, and the airbag ball 17 transports gas to the interior of the cavity 14 through the connecting tube 16. Then the airbag ball 17 is reset to suck out the air inside the cavity 14, thereby forming pressure inside the cavity 14, which can suck out excess liquid medicine inside the inner support tube 8 and the outer support tube 10.

[0043] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0044] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A postoperative conformable frontal sinus stent for sustained-release drug delivery via nasal endoscopic surgery, comprising an outer tube (1), characterized in that: The outside of the outer tube (1) is fixedly connected to a fixing ring (2), the inside of the fixing ring (2) is fixedly connected to a plurality of connecting tubes (3), the bottoms of the plurality of connecting tubes (3) are fixedly connected to a medicine storage tube (4), the outside of the connecting tube (3) is fixedly connected to an inner support tube (8), the inside of the inner support tube (8) is provided with a plurality of medicine outlet holes (9), the outside of the inner support tube (8) is fixedly connected to an outer support tube (10), the inside of the outer support tube (10) is provided with a plurality of medicine outlet holes (11), and the outside of the outer tube (1) is provided with a liquid collecting component and a limiting component.

2. A sustained-release drug delivery post-endoscopic nasal surgery conformable frontal sinus stent according to claim 1, characterized in that: The liquid collecting component comprises an adjusting ring (13), the interior of the adjusting ring (13) is slidably connected to the exterior of the outer tube (1), a cavity (14) and a mounting hole (15) are provided inside the adjusting ring (13), a connecting tube (16) is detachably connected to the interior of the mounting hole (15), and the other end of the connecting tube (16) is fixedly connected to an airbag ball (17).

3. A sustained-release drug delivery post-endoscopic nasal surgery conformable frontal sinus stent according to claim 1, characterized in that: A push rod (5) is slidably connected inside the medicine storage tube (4), one end of the push rod (5) is fixedly connected to a piston (6), and a plurality of rubber blocks (7) are fixedly connected inside the medicine storage tube (4).

4. A sustained-release post-endoscopic nasal sinus stent according to claim 1, characterized in that: The limiting assembly comprises a plurality of limiting rods (19), one end of each limiting rod (19) is fixedly connected to the inside of the adjusting ring (13), and a plurality of limiting grooves (20) are formed on the outside of the outer tube (1).

5. A postoperative conformable frontal sinus stent for sustained-release drug delivery via nasal endoscopic surgery according to claim 3, characterized in that: The outside of the piston (6) is slidably connected to the inner wall of the medicine storage tube (4), and the outside of the piston (6) is in contact with the outside of the rubber block (7).

6. A postoperative conformable frontal sinus stent for sustained-release drug delivery via nasal endoscopic surgery according to claim 4, characterized in that: The outside of the limiting rod (19) is slidably connected to the inner wall of the limiting groove (20), and the outside of the outer tube (1) is provided with a thread groove (22).

7. The sustained-release post-endoscopic nasal sinus stent according to claim 1, characterized in that: The outer portion of the outer tube (1) is rotatably connected to a plurality of rotating support rods (12), and the other end of the rotating support rod (12) is rotatably connected to the outside of the outer support tube (10).

8. The sustained-release post-endoscopic frontal sinus stent according to claim 1, characterized in that: A drug delivery hole (18) is fixedly connected inside the front end of the outer tube (1), and a cone head (21) is fixedly connected to the top of the outer tube (1).

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