Essence with repairing and moisturizing functions and preparation method thereof

Abstract

The invention relates to the technical field of skin care products, in particular to essence with repairing and moisturizing functions and a preparation method thereof.The essence is prepared from, by mass, 0.3%-0.7% of active caffeine, 5%-10% of humectants, 0.3%-0.6% of preservatives, 15%-25% of skin activating ingredients, 0.05%-0.5% of bisabolol, 0.2%-0.6% of stabilizers, 2%-4% of potassium azelaic diglycinate, 0.05%-0.3% of vitamin E and the balance water. And the balance of deionized water. The essence has repairing and moisturizing functions, is non-toxic, harmless and non-irritant to skin, and can relieve facial acnes and inhibit growth and reproduction of propionibacterium acnes.

Description

Technical Field

[0001] The invention relates to the technical field of skin care products, and in particular to an essence with repairing and moisturizing functions and a preparation method thereof. Background Art

[0002] As an indispensable part of modern skin care routine, the origin and development of essence is deeply rooted in people's constant pursuit of skin health and beauty. As early as in ancient times, people have begun to try to use various natural plant extracts, herbs and minerals to nourish and protect the skin. Although these primitive "essences" are simple in form, they contain the earliest skin care wisdom. With the advancement of science and technology and the rise of cosmetic science, essences have gradually developed from folk remedies to highly effective skin care products that have been strictly formulated and scientifically verified.

[0003] After the mid-20th century, with the rapid development of disciplines such as biochemistry and skin physiology, skin care brands began to conduct in-depth research on skin structure and function, identify the root causes of different skin problems, and develop targeted essences based on this. These products usually contain high concentrations of active ingredients such as vitamin C, hyaluronic acid, peptides, antioxidants and plant essences, etc., aiming to penetrate deep into the skin to solve signs of aging such as dryness, dullness, fine lines, sagging, etc., while enhancing the skin's self-repair and protection capabilities.

[0004] The reason why essence stands out among many skin care products is due to its unique texture and efficacy. Compared with lotions and creams, essence molecules are smaller and have stronger penetration. They can quickly penetrate the surface of the skin and reach the dermis to achieve deep nourishment and repair. In addition, essences are usually light and non-greasy, suitable for all skin types, and easy to stack with other skin care products to provide comprehensive and meticulous care for the skin.

[0005] In recent years, with the growing demand for personalized skin care from consumers, the essence market has also shown a diversified development trend, from basic moisturizing, whitening, and anti-wrinkle, to specific care for sensitive skin, oily skin, and acne skin, and then to the combination of modern biotechnology such as microcapsule technology and nanotechnology and other innovative applications, essences are constantly being innovated to meet the precise skin care needs of different groups of people and different skin conditions. It has not only become a must-have recommended by professional beauticians, but also deeply loved by consumers, becoming an indispensable part of the modern skin care program.

[0006] For example, CN115089509B discloses that "essence and facial mask" are prepared using active ingredients, auxiliary materials and water as raw materials, wherein the active ingredients are selected from at least two of ceramide, astaxanthin and resveratrol, and the essence has good antioxidant properties.

[0007] For example, CN105997828B discloses a "water-light essence" prepared with skin conditioners, moisturizers, emollients, chelating agents, fragrances, preservatives, antioxidants, thickeners and water as raw materials. The essence has excellent anti-inflammatory and anti-allergic, moisturizing, whitening and lightening, acne and anti-wrinkle, and skin repair functions.

[0008] For another example, CN114601771B discloses “a soothing essence and its preparation method” which is prepared from sodium carboxymethyl β-glucan, carboxymethyl chitosan, gentian root extract, kava leaf / root / stem / extract, white osmanthus extract, moisturizer, thickener and solvent as raw materials. The essence has the advantage of protecting Langerhans cells.

[0009] However, for some patients with facial acne, the essence prepared by the above-mentioned patent cannot effectively treat this group of people. Acne is a chronic inflammatory skin disease caused by abnormal secretion and metabolism of skin oil.

[0010] Therefore, it is urgent to develop an essence that has the function of repairing and moisturizing, is non-toxic, harmless and non-irritating to the skin, can relieve facial acne, and inhibit the growth and reproduction of Propionibacterium acnes. Summary of the invention

[0011] The main purpose of the present invention is to provide an essence with repairing and moisturizing functions and a preparation method thereof. The essence has repairing and moisturizing functions, is non-toxic and harmless to the skin, can relieve facial acne, and inhibit the growth and reproduction of Propionibacterium acnes.

[0012] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0013] On the one hand, the present invention provides an essence with repairing and moisturizing functions, which comprises the following components, calculated by mass percentage as 100%, 0.3-0.7% active caffeine, 5-10% moisturizer, 0.3-0.6% preservative, 15-25% skin-activating ingredients, 0.05-0.5% bisabolol, 0.2-0.6% stabilizer, 2-4% potassium azelayl diglycinate and 0.05-0.3% vitamin E, and the balance is deionized water.

[0014] The essence of the present application is prepared with active caffeine, moisturizer, preservative, skin revitalizing ingredient, bisabolol, stabilizer, potassium azelayl diglycinate, vitamin E and water in a specific ratio as main raw materials. It is non-toxic, harmless and non-irritating to the skin. The moisturizer and skin revitalizing ingredient are prepared by synergistic combination of specific components, which can improve the moisturizing and hydrating ability of the essence, repair the skin and improve the resistance to UV damage, and can also reduce facial acne.

[0015] In some embodiments, the moisturizer includes the following components in parts by weight: 10 to 30 parts of polyethylene glycol-8, 10 to 30 parts of 1,3-propylene glycol, 10 to 20 parts of water-soluble silicone wax, 5 to 15 parts of methyl glucoside polyoxyethylene ether-20, 5 to 15 parts of glycerol polyether-26, 5 to 15 parts of butylene glycol, 1 to 5 parts of sodium hyaluronate and 1 to 3 parts of neural anti-aging factors.

[0016] In some embodiments, the preservative comprises phenoxyethanol and ethylhexylglycerin in a mass ratio of (2.5-3.5):1.

[0017] The present application can improve not only the antiseptic ability of the essence but also the antibacterial ability of the essence by regulating a specific ratio of phenoxyethanol and ethylhexylglycerin. The reason may be that ethylhexylglycerin has a structure similar to that of a surfactant, which can affect the interfacial tension of the microbial cell membrane, allowing the preservative to penetrate into the microbial cells more effectively, thereby significantly improving the antiseptic and antibacterial effects of traditional preservatives. However, its own antiseptic effect is poor and needs to be used in conjunction to achieve the above-mentioned effects.

[0018] In some embodiments, the revitalizing ingredient includes the following components in parts by weight: 80 to 90 parts of bifid yeast lysate, 8 to 13 parts of 8 to 13 wt% baobab seed extract aqueous solution, 18 to 24 parts of rhythmic peptides, 28 to 34 parts of 2 to 8 wt% yeast extract aqueous solution, 8 to 12 parts of 5 to 15 wt% lactic acid bacteria fermentation product aqueous solution, 8 to 12 parts of 7 to 15 wt% Sudan cola nut seed extract aqueous solution, 8 to 12 parts of 6 to 15 wt% white chamomile extract aqueous solution, 2 to 7 parts of panthenol, 0.2 to 0.7 parts of 8 to 13 wt% sodium ribonucleic acid aqueous solution, 1.5 to 2.5 parts of squalane, 0.5 to 1.5 parts of polyoxyethylene lauryl alcohol ether, 0.2 to 0.7 parts of hydrogenated lecithin, 0.5 to 1.5 parts of jojoba wax and 0.5 to 1.5 parts of ceteareth-20.

[0019] In some embodiments, the stabilizer includes EDTA-4 and modified chitosan in a mass ratio of 1:(0.1-0.5).

[0020] The present application can improve the stability of the essence by regulating the mass ratio of EDTA-4 and modified chitosan, and at the same time have excellent antibacterial properties.

[0021] In some embodiments, the method for preparing the modified chitosan comprises the following steps:

[0022] A1. In an inert protective gas atmosphere, chitosan, catechin and ethanol are mixed, the temperature is raised to reflux, and the mixture is stirred at a constant temperature for 4 to 8 hours. After the reaction is completed, the mixture is concentrated under reduced pressure to obtain catechin-grafted chitosan;

[0023] A2. In an inert protective gas atmosphere, the catechin-grafted chitosan in step A1 is mixed with fatty acid chloride and added into N,N-dimethylformamide, and stirred at room temperature for 4 to 6 hours. After the reaction is completed, ice water is added until no solid is produced. After filtering, the mixture is washed with water and freeze-dried to obtain modified chitosan.

[0024] The essence formula of the present application contains two components, an aqueous phase and an oily phase. It is well known that the aqueous phase and the oily phase have poor compatibility and stratification occurs when they are compounded. Therefore, the conventional method is to add more surfactants to allow the two to be fully mixed. However, common surfactants such as sodium dodecyl sulfate and sodium lauryl polyoxyethylene ether sulfate have a certain irritating effect on people with sensitive skin, which leads to a narrow scope of application of such surfactants.

[0025] The modified chitosan of the present application is prepared using two natural ingredients, namely chitosan and catechins, as main raw materials, and can not only play the role of a surfactant to make the various components in the essence more evenly dispersed, but also the prepared essence can improve the skin's resistance to ultraviolet damage and is non-irritating to the skin. The reason may be that, on the one hand, the modified chitosan is modified by grafting catechins into the chitosan structure, which not only destroys the internal hydrogen bonds of the chitosan but also provides a large number of hydrophilic groups to increase the hydrophilicity of the modified chitosan. At the same time, the fatty acid chloride is reacted with the modified chitosan to improve the hydrophobicity of the modified chitosan, so that the modified chitosan has the role of a surfactant and can improve the stability of the various components in the essence; on the other hand, catechins are grafted into the chitosan structure, and when used, the modified chitosan can adhere to the skin surface to form a protective film, thereby improving the skin's resistance to ultraviolet damage.

[0026] In some embodiments, in step A1, the mass ratio of chitosan to catechin is 1:(0.2-0.5).

[0027] In some embodiments, in step A2, the mass ratio of the catechin-grafted chitosan to the fatty acid chloride is 1:(0.3-0.6).

[0028] In some embodiments, the fatty acyl chloride is a C18-C24 fatty acyl chloride.

[0029] Another aspect of the present invention provides a method for preparing an essence having a repairing and moisturizing function, comprising the following steps:

[0030] S1. Mix active caffeine and water and stir evenly, raise the temperature to 40-60°C, and stir at constant temperature for 20-40 minutes to obtain material A;

[0031] S2. Under constant temperature stirring, add the moisturizer to material A in step S1, stir for 1 to 3 hours, and obtain material B;

[0032] S3, under constant temperature stirring, add the preservative, skin revitalizing ingredients and potassium azelayl diglycinate to material B in step S2, and stir for 20 to 40 minutes to obtain material C;

[0033] S4. Under constant temperature stirring, add bisabolol, vitamin E and stabilizer to material C in step S3, and adjust the pH of the system to 5-6 to obtain an essence.

[0034] Compared with the prior art, the present invention has the following beneficial effects:

[0035] (1) The essence of the present invention is prepared with active caffeine, moisturizer, preservative, skin-activating ingredient, bisabolol, stabilizer, potassium azelayl diglycinate, vitamin E and water in a specific ratio as main raw materials, and is non-toxic, harmless and non-irritating to the skin. The moisturizer and skin-activating ingredient are prepared by synergistically selecting several specific components, which can improve the moisturizing and hydrating ability of the essence, repair the skin and improve the resistance to ultraviolet damage, and can also reduce facial acne.

[0036] (2) The preservative of the present invention is a compound of phenoxyethanol and ethylhexylglycerin in a specific ratio, which can not only improve the antiseptic ability of the essence, but also improve the antibacterial ability of the essence.

[0037] (3) The stabilizer of the present invention is a combination of EDTA-4 and modified chitosan in a specific ratio, which can improve the stability of the essence and also improve the anti-ultraviolet ability of the essence and reduce the irritation to the skin.

[0038] (4) The modified chitosan of the present invention is prepared using two natural ingredients, namely chitosan and catechins, as main raw materials and is mild and friendly to the skin; the modified chitosan is prepared by grafting catechins onto the chitosan in its structure, which not only destroys the internal hydrogen bonds of the chitosan but also provides a large number of hydrophilic groups to increase the hydrophilicity of the modified chitosan. At the same time, the fatty acid chloride is reacted with the modified chitosan to improve the hydrophobicity of the modified chitosan, so that the modified chitosan has the function of a surfactant and can improve the stability of each component in the essence; in addition, catechins are grafted into the modified chitosan structure, and when used, the modified chitosan can adhere to the skin surface to form a protective film, thereby improving the skin's ability to resist ultraviolet damage. DETAILED DESCRIPTION

[0039] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0040] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0041] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as commonly understood by those skilled in the art. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein may also be used in the practice or testing of the present invention. Various modifications and variations may be made to the specific embodiments of the present invention specification without departing from the scope or spirit of the present invention, which will be apparent to those skilled in the art. Other embodiments obtained from the present invention specification will be apparent to the technician. The present application specification and examples are exemplary only.

[0042] It should be noted that the operations of "drying", "filtering" and "stirring" described in the present invention are routine operations of those skilled in the art and can be selected according to actual operations.

[0043] In the following examples and comparative examples, polyethylene glycol-8 was purchased from Shanghai Hongfan Biotechnology Co., Ltd.; methyl glucoside polyoxyethylene ether-20 and hydrogenated lecithin were purchased from Wuhan Lanabai Pharmaceutical Chemical Co., Ltd.; water-soluble silicone wax, glycerol polyether-26, and sodium hyaluronate were purchased from Jining Fangyu Chemical Co., Ltd.; neural anti-aging factor was purchased from Laiyu Biotechnology (International) Group; bifid yeast lysate, baobab seed extract, and sodium ribonucleic acid were purchased from Guangdong Fangxin Biotechnology Co., Ltd.; lactobacillus fermentation product was purchased from Guangzhou Si Noko Biotechnology Co., Ltd.; yeast extract was purchased from Henan Jimei Chemical Products Co., Ltd.; Sudan kola nut seed extract CAS No.: 89997-82-0; white chamomile extract was purchased from Guangzhou Goldman Chemical Co., Ltd.; panthenol and vitamin E were purchased from Hubei Haijia Biotechnology Co., Ltd.; polyoxyethylene lauryl ether CAS No.: 9002-92-0; jojoba wax, cetearyl alcohol polyether-20 and chitosan were purchased from Wuhan Huaxiang Kejie Biotechnology Co., Ltd.; active caffeine CAS No.: 58-08-2.

[0044] Unless otherwise specified in the following examples and comparative examples, the moisturizer includes the following components by weight: 20 parts of polyethylene glycol-8, 15 parts of 1,3-propylene glycol, 15 parts of water-soluble silicone wax, 10 parts of methyl glucoside polyoxyethylene ether-20, 10 parts of glycerol polyether-26, 10 parts of butylene glycol, 3 parts of sodium hyaluronate and 2 parts of neural anti-aging factor;

[0045] The preservatives include phenoxyethanol and ethylhexylglycerin in a mass ratio of 3:1;

[0046] The skin revitalizing ingredient includes the following components by weight: 85 parts of bifid yeast lysate, 10 parts of 10wt% baobab seed extract aqueous solution, 20 parts of rhythm peptide, 30 parts of 5wt% yeast extract aqueous solution, 10 parts of 10wt% lactobacillus fermentation product aqueous solution, 10 parts of 10wt% Sudan cola nut seed extract aqueous solution, 10 parts of 10wt% white chamomile extract aqueous solution, 5 parts of panthenol, 0.5 parts of 10wt% sodium ribonucleate aqueous solution, 2 parts of squalane, 1 part of polyoxyethylene lauryl alcohol ether, 0.5 parts of hydrogenated lecithin, 1 part of jojoba wax and 1 part of ceteareth-20;

[0047] The stabilizer comprises EDTA-4 and modified chitosan in a mass ratio of 1:0.3.

[0048] Preparation Example 1

[0049] The preparation method of modified chitosan comprises the following steps:

[0050] A1. In a N2 atmosphere, 50 g of chitosan, 20 g of catechins and 1 L of ethanol were mixed, the temperature was raised to reflux, and the mixture was stirred at a constant temperature for 6 h. After the reaction was completed, the mixture was concentrated under reduced pressure to obtain catechin-grafted chitosan;

[0051] A2. Under N2 atmosphere, 50 g of the catechin-grafted chitosan prepared in step A1 was mixed with 25 g of octadecanoyl chloride, and 700 mL of N,N-dimethylformamide was added. The mixture was stirred at room temperature for 5 h. After the reaction, ice water was added until no solid was produced. The mixture was filtered, washed with water, and freeze-dried to obtain modified chitosan.

[0052] Preparation Example 2

[0053] The preparation method of modified chitosan is the same as that of Preparation Example 1, except that the amount of catechin is 29 g.

[0054] Preparation Example 3

[0055] The preparation method of modified chitosan is the same as that of Preparation Example 1, except that the amount of catechin is 6 g.

[0056] Preparation Example 4

[0057] The preparation method of modified chitosan is the same as that of Preparation Example 1, except that the amount of octadecanoyl chloride is 34 g.

[0058] Preparation Example 5

[0059] The preparation method of modified chitosan is the same as that of Preparation Example 1, except that the amount of octadecanoyl chloride is 11 g.

[0060] Preparation Example 6

[0061] The specific implementation method of the modified chitosan is the same as that of Preparation Example 1, except that an equal mass of pentadecanoyl chloride is used instead of octadecanoyl chloride.

[0062] Example 1

[0063] A serum with repairing and moisturizing functions comprises the following components based on 100% by mass: 0.5% active caffeine, 7% moisturizer, 0.5% preservative, 20% skin-activating ingredient, 0.2% bisabolol, 0.4% stabilizer, 3% potassium azelayl diglycinate and 0.15% vitamin E, with the balance being deionized water.

[0064] Wherein, the modified chitosan is prepared by Preparation Example 1.

[0065] A method for preparing an essence with repairing and moisturizing functions comprises the following steps:

[0066] S1. Mix active caffeine and water and stir evenly, raise the temperature to 50°C, and stir at constant temperature for 30 minutes to obtain material A;

[0067] S2. Under constant temperature stirring, add the moisturizer to material A in step S1, stir for 2 hours, and obtain material B;

[0068] S3, under constant temperature stirring, add the preservative, skin revitalizing ingredients and potassium azelayl diglycinate to material B in step S2, and stir for 30 minutes to obtain material C;

[0069] S4. Under constant temperature stirring, add bisabolol, vitamin E and stabilizer to material C in step S3, and use 10 wt % arginine citric acid to adjust the pH of the system to 5.5 to obtain an essence.

[0070] Example 2

[0071] A serum with repairing and moisturizing functions comprises the following components based on 100% by mass: 0.3% active caffeine, 5% moisturizer, 0.3% preservative, 15% skin-activating ingredient, 0.05% bisabolol, 0.2% stabilizer, 2% potassium azelayl diglycinate and 0.05% vitamin E, with the balance being deionized water.

[0072] Wherein, the modified chitosan is prepared by Preparation Example 1.

[0073] A method for preparing an essence with repairing and moisturizing functions comprises the following steps:

[0074] S1. Mix active caffeine and water and stir evenly, raise the temperature to 40°C, and stir at constant temperature for 40 minutes to obtain material A;

[0075] S2. Under constant temperature stirring, add the moisturizer to material A in step S1, stir for 3 hours, and obtain material B;

[0076] S3, under constant temperature stirring, add the preservative, skin revitalizing ingredients and potassium azelayl diglycinate to material B in step S2, and stir for 40 minutes to obtain material C;

[0077] S4. Under constant temperature stirring, add bisabolol, vitamin E and stabilizer to material C in step S3, and use 10 wt % arginine citric acid to adjust the pH of the system to 5 to obtain an essence.

[0078] Example 3

[0079] A serum with repairing and moisturizing functions comprises the following components based on 100% by mass: 0.7% active caffeine, 10% moisturizer, 0.6% preservative, 25% skin-activating ingredient, 0.5% bisabolol, 0.6% stabilizer, 4% potassium azelayl diglycinate and 0.3% vitamin E, with the balance being deionized water.

[0080] Wherein, the modified chitosan is prepared by Preparation Example 1.

[0081] A method for preparing an essence with repairing and moisturizing functions comprises the following steps:

[0082] S1. Mix active caffeine and water and stir evenly, raise the temperature to 60°C, and stir at constant temperature for 20 minutes to obtain material A;

[0083] S2. Under constant temperature stirring, add the moisturizer to material A in step S1, stir for 1 hour, and obtain material B;

[0084] S3. Add the preservative, skin-activating ingredients and potassium azelayl diglycinate to material B in step S2 under constant temperature stirring, and stir for 20 minutes to obtain material C;

[0085] S4. Under constant temperature stirring, add bisabolol, vitamin E and stabilizer to material C in step S3, and use 10 wt % arginine citric acid to adjust the pH of the system to 6 to obtain an essence.

[0086] Example 4

[0087] A serum with repairing and moisturizing functions and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that the modified chitosan is prepared by Preparation Example 2.

[0088] Example 5

[0089] A serum with repairing and moisturizing functions and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that the modified chitosan is prepared by Preparation Example 3.

[0090] Example 6

[0091] A serum with repairing and moisturizing functions and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the modified chitosan is prepared by Preparation Example 4.

[0092] Example 7

[0093] A serum with repairing and moisturizing functions and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that the modified chitosan is prepared by Preparation Example 5.

[0094] Example 8

[0095] A serum with repairing and moisturizing functions and a preparation method thereof. The specific implementation method is the same as Example 1, except that the modified chitosan is prepared by Preparation Example 6.

[0096] Example 9

[0097] A serum with repairing and moisturizing functions and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that an equal mass of chitosan is used instead of modified chitosan.

[0098] Example 10

[0099] A serum with repairing and moisturizing functions and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that the preservative comprises phenoxyethanol and ethylhexylglycerin in a mass ratio of 4.5:1.

[0100] Performance Testing:

[0101] (1) Stability test: Take the essence and place it in a 40°C environment for 24 hours, a room temperature environment for 24 hours, and a -5°C environment for 24 hours. Repeat the test three times to observe whether there is any delamination, oil floating, or color.

[0102] (2) DPPH radical scavenging rate: Prepare water dilutions of essence with concentrations of 10, 5, 3, 1, and 0.5 mg / mL. Take 2 mL of the water dilutions of essence with different concentrations and mix them with 2 mL of 0.2 mmol / L DPPH ethanol solution. React in the dark for 30 min. The absorbance of the test mixture at 517 nm is recorded as A1. Take another 2 mL of the water dilutions of essence and mix them with 2 mL of ethanol. React in the dark for 30 min. The absorbance of the test mixture at 517 nm is recorded as A2. Then, mix 2 mL of 0.2 mmol / L DPPH ethanol solution with 2 mL of ethanol. React in the dark for 30 min. The absorbance of the test mixture at 517 nm is recorded as A0.

[0103]

[0104] (3) Inhibition zone test: 1 g of the essence was added to 20 ml of 50 wt% ethanol solution and stirred to dissolve to obtain an essence ethanol solution for use. Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa were inoculated into test tube culture medium respectively. After culturing at 37°C in an incubator for 48 hours, aseptically treated distilled water was added and shaken to obtain two experimental bacterial suspensions. 15 ml of melted SOB culture medium was taken and placed in a sterile plate. Then, 1 ml of the two experimental bacterial suspensions were added dropwise and spread on the bottom of the plate. After the culture medium solidified, 4 Oxford cups were placed upright on each plate, and 0.1 ml of the essence ethanol solution was added respectively. After culturing at 37°C for 24 hours, the diameters of the inhibition zones were measured respectively.

[0105] The essences of the embodiments and comparative examples were tested according to the above methods (1) to (3). The test results are shown in Table 1.

[0106] Table 1

[0107]

[0108] According to the data in Table 1, the essences prepared in Examples 1 to 3 have high stability and good anti-ultraviolet oxidation and antibacterial effects; in Example 4, due to the change in the mass ratio of chitosan and catechins, the catechin content increased, the surface activity of the modified chitosan weakened, resulting in decreased stability and antibacterial properties of the essence; in Example 5, due to the change in the mass ratio of chitosan and catechins, the catechin content decreased, the surface activity of the modified chitosan weakened, resulting in decreased stability, anti-ultraviolet oxidation and antibacterial properties of the essence; in Example 6, due to the change in the mass ratio of catechin-grafted chitosan and octadecanoyl chloride, the increase in octadecanoyl chloride weakened the surface activity of the modified chitosan, and the catechin content decreased. The relative content of tea elements decreased, resulting in decreased stability, anti-ultraviolet oxidation and antibacterial properties of the essence; in Example 7, due to the change in the mass ratio of catechin-grafted chitosan and octadecanoyl chloride, the reduction of octadecanoyl chloride weakened the surface activity of the modified chitosan, resulting in decreased stability and antibacterial properties of the essence; in Example 8, due to the use of an equal mass of pentadecanoyl chloride instead of octadecanoyl chloride, the surface activity of the modified chitosan was weakened, resulting in decreased stability and antibacterial properties of the essence; in Example 9, due to the use of an equal mass of chitosan instead of modified chitosan, the stability, anti-ultraviolet oxidation and antibacterial properties of the essence decreased; in Example 10, due to the change in the mass ratio of phenoxyethanol and ethylhexylglycerin, the antibacterial properties of the essence decreased.

[0109] (4) Irritation and skin repair test: 10 female volunteers with sensitive skin were randomly selected, and the skin repair test was performed with reference to the test method of Experiment 3 disclosed in paragraph

[0122] of CN114601771B to obtain the average value, and observe whether the subjects have allergic reactions.

[0110] The essence prepared in Example 1 was tested according to the above test method (4). The test results are shown in Table 2.

[0111] Table 2

[0112] Skin wrinkle change rate (%) Whether an allergic reaction occurs Example 1 -0.04 None of the 10 subjects had any allergic reactions

[0113] According to the data in Table 2, the essence of the present application has a certain repairing effect on the skin and delays the formation of wrinkles. At the same time, the essence made by synergizing several ingredients in a specific ratio has no irritating effect on the skin and is more friendly to people with sensitive skin.

[0114] Finally, it should be noted that the above specific implementation methods are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to examples, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the spirit and scope of the technical solution of the present invention, which should be included in the scope of the claims of the present invention.

Claims

1. An essence with repairing and moisturizing function, characterized in that: The invention comprises the following components in percentage by mass: 0.3-0.7% active caffeine, 5-10% moisturizer, 0.3-0.6% preservative, 15-25% skin revitalizing ingredient, 0.05-0.5% bisabolol, 0.2-0.6% stabilizer, 2-4% potassium azelayl diglycinate and 0.05-0.3% vitamin E, and the balance is deionized water.

2. The essence with repairing and moisturizing function according to claim 1, characterized in that: The moisturizing agent includes the following components in parts by weight: 10 to 30 parts of polyethylene glycol-8, 10 to 30 parts of 1,3-propylene glycol, 10 to 20 parts of water-soluble silicone wax, 5 to 15 parts of methyl glucoside polyoxyethylene ether-20, 5 to 15 parts of glycerol polyether-26, 5 to 15 parts of butylene glycol, 1 to 5 parts of sodium hyaluronate and 1 to 3 parts of neural anti-aging factors.

3. The essence with repairing and moisturizing function according to claim 1, characterized in that: The preservative comprises phenoxyethanol and ethylhexylglycerin in a mass ratio of (2.5-3.5):

1.

4. The essence with repairing and moisturizing function according to claim 1, characterized in that: The skin-activating ingredient includes the following components in parts by weight: 80 to 90 parts of bifid yeast lysate, 8 to 13 parts of 8 to 13 wt% baobab seed extract aqueous solution, 18 to 24 parts of rhythmic peptides, 28 to 34 parts of 2 to 8 wt% yeast extract aqueous solution, 8 to 12 parts of 5 to 15 wt% lactobacillus fermentation product aqueous solution, 8 to 12 parts of 7 to 15 wt% Sudan cola nut seed extract aqueous solution, 8 to 12 parts of 6 to 15 wt% white chamomile extract aqueous solution, 2 to 7 parts of panthenol, 0.2 to 0.7 parts of 8 to 13 wt% sodium ribonucleic acid aqueous solution, 1.5 to 2.5 parts of squalane, 0.5 to 1.5 parts of polyoxyethylene lauryl alcohol ether, 0.2 to 0.7 parts of hydrogenated lecithin, 0.5 to 1.5 parts of jojoba wax and 0.5 to 1.5 parts of ceteareth-20.

5. The essence with repairing and moisturizing function according to claim 1, characterized in that: The stabilizer comprises EDTA-4 and modified chitosan in a mass ratio of 1:(0.1-0.5).

6. The essence with repairing and moisturizing function according to claim 5, characterized in that: The preparation method of the modified chitosan comprises the following steps: A1. In an inert protective gas atmosphere, chitosan, catechin and ethanol are mixed, the temperature is raised to reflux, and the mixture is stirred at a constant temperature for 4 to 8 hours. After the reaction is completed, the mixture is concentrated under reduced pressure to obtain catechin-grafted chitosan; A2. In an inert protective gas atmosphere, the catechin-grafted chitosan in step A1 is mixed with fatty acid chloride and added into N,N-dimethylformamide, and stirred at room temperature for 4 to 6 hours. After the reaction is completed, ice water is added until no solid is produced. After filtering, the mixture is washed with water and freeze-dried to obtain modified chitosan.

7. The essence with repairing and moisturizing function according to claim 6, characterized in that: In step A1, the mass ratio of chitosan to catechin is 1:(0.2-0.5).

8. The essence with repairing and moisturizing function according to claim 6, characterized in that: In step A2, the mass ratio of the catechin-grafted chitosan to the fatty acid chloride is 1:(0.3-0.6).

9. The essence with repairing and moisturizing function according to claim 6, characterized in that: The fatty acyl chloride is a C18-C24 fatty acyl chloride.

10. A method for preparing the essence with repairing and moisturizing function according to any one of claims 1 to 9, characterized in that: The steps include: S1. Mix active caffeine and water and stir evenly, raise the temperature to 40-60°C, and stir at constant temperature for 20-40 minutes to obtain material A; S2. Under constant temperature stirring, add the moisturizer to material A in step S1, stir for 1 to 3 hours, and obtain material B; S3, under constant temperature stirring, add the preservative, skin revitalizing ingredients and potassium azelayl diglycinate to material B in step S2, and stir for 20 to 40 minutes to obtain material C; S4. Under constant temperature stirring, add bisabolol, vitamin E and stabilizer to material C in step S3, and adjust the pH of the system to 5-6 to obtain an essence.

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