Montmorillonite suspension and preparation method thereof

Abstract

The invention discloses a montmorillonite suspension and a preparation method thereof.The montmorillonite suspension is prepared from modified montmorillonite, a nonionic polymer suspending aid, a coloring agent, an aromatic, a sweetening agent and deionized water, and the preparation method comprises the steps that 1, raw materials are weighed; step 2, ion exchange; step 3, grafting modification; 4, mixing the raw materials; in the first step, the ion exchanger is one of hexadecyl trimethyl ammonium bromide, dodecyl dimethyl benzyl ammonium chloride, octadecyl trimethyl ammonium chloride, tetrabutylammonium bromide and silver nitrate; the montmorillonite is modified through ion exchange and surface grafting, the adsorption capacity of the montmorillonite is improved through ion exchange, antibacterial and anti-inflammatory ions, mucous membrane repairing substances and hydrophobic groups are introduced through surface grafting, and the montmorillonite is endowed with multifunctionality; hydrophobic modification improves the stability of the suspension and reduces the adverse effect of organic additives on the drug effect, the antibacterial and mucous membrane repairing functions improve the drug performance, and the application field is expanded.

Description

Technical Field

[0001] The invention relates to the technical field of medicines, in particular to a montmorillonite suspension and a preparation method thereof. Background Art

[0002] The main ingredient of montmorillonite suspension is montmorillonite. It is an antidiarrheal drug used for acute and chronic diarrhea in adults and children. In terms of formula, montmorillonite suspension is generally prepared by mixing montmorillonite, suspending agents, colorants, fragrances, sweeteners and water. Its main ingredients are relatively simple and its functions are relatively limited. Therefore, it has the following disadvantages: 1. Montmorillonite suspension mainly uses montmorillonite to fix and inhibit viruses, bacteria and toxins produced in the digestive tract to achieve the purpose of antidiarrhea. Therefore, its function is relatively simple and lacks in comprehensive treatment; 2. Montmorillonite suspension relies on the effect of suspending agents to reduce sedimentation. If the suspending agent is not properly selected, the dosage is inaccurate, or the properties change due to environmental factors during storage, it is easy to cause montmorillonite particles to agglomerate and precipitate, making the drug concentration uneven before use, thereby affecting the accuracy and effectiveness of each administration; 3. Organic additives will adsorb on the surface of montmorillonite, reducing the adsorption affinity for viruses, bacteria and their toxins, thereby affecting its sterilization effect. Summary of the invention

[0003] The purpose of the present invention is to provide a montmorillonite suspension and a preparation method thereof to solve the problems raised in the above background technology.

[0004] To achieve the above purpose, the present invention provides the following technical scheme: a montmorillonite suspension, the formula of which includes: modified montmorillonite, non-ionic polymer suspending agent, colorant, aromatic, sweetener and deionized water, the mass percentage content of each component is: 25-35% of modified montmorillonite, 0.5-1.5% of non-ionic polymer suspending agent, 0.01-0.1% of colorant, 0.01-0.1% of aromatic and 0.05-0.2% of sweetener, and the balance is deionized water.

[0005] Preferably, the mass percentage contents of the components are: 30% of modified montmorillonite, 1% of non-ionic polymer suspending agent, 0.05% of colorant, 0.05% of flavoring agent and 0.1% of sweetener, and the balance is deionized water.

[0006] Preferably, the polymer suspending agent is one of RC591, hydroxypropyl cellulose, xanthan gum, carrageenan and carbomer.

[0007] Preferably, the fragrance is one of apple flavor, strawberry flavor, lemon flavor and mint flavor.

[0008] Preferably, the sweetener is one of fructose and sucralose, and the colorant is one of carotenoid, anthocyanin and caramel pigment.

[0009] A method for preparing a montmorillonite suspension comprises the following steps: first, weighing raw materials; second, ion exchange; third, graft modification; and fourth, mixing raw materials;

[0010] In the above step 1, based on the sum of the mass percentages of the components being 1, 75% of montmorillonite, 10% of ion exchanger, 14% of surface grafting monomer and 1% of initiator are weighed;

[0011] In the above step 2, the montmorillonite weighed in step 1 is uniformly dispersed in deionized water, and then an ion exchanger is added. After sufficient reaction, the solid is separated by centrifugation, and then washed with deionized water for 3-5 times to remove the unreacted ion exchanger to obtain the montmorillonite after ion exchange;

[0012] In the above step 3, the montmorillonite after ion exchange in step 2 is taken and evenly dispersed in deionized water, and then the surface grafting monomer is added, and the initiator is added after uniform dispersion. After sufficient reaction, the solid is separated by centrifugation, and then washed with deionized water for 3-5 times to remove the unreacted ion exchanger, and the montmorillonite after ion exchange is obtained after vacuum drying;

[0013] In the above step 4, raw materials are weighed according to the formula of montmorillonite suspension, and the raw materials are mixed evenly to obtain montmorillonite suspension.

[0014] Preferably, in step 1, the ion exchanger is one of hexadecyltrimethylammonium bromide, dodecyldimethylbenzylammonium chloride, octadecyltrimethylammonium chloride, tetrabutylammonium bromide and silver nitrate.

[0015] Preferably, in step one, the surface grafting monomer and the initiator are one of the following combinations: the surface grafting monomer is acrylic acid and N-vinyl pyrrolidone, and the initiator is ammonium persulfate and sodium bisulfite; the surface grafting monomer is methyl methacrylate and acrylamide, and the initiator is azobisisobutyronitrile; the surface grafting monomer is itaconic acid and 2-hydroxyethyl methacrylate, and the initiator is benzoyl peroxide; the surface grafting monomer is styrene and hydroxyethyl acrylate, and the initiator is benzoyl peroxide; the surface grafting monomer is chitosan, and the initiator is glutaraldehyde.

[0016] Preferably, in step 2, the reaction temperature is 25-60°C, the centrifugal speed is 2000-3500 r / min, and the centrifugal time is 10-15 min.

[0017] Preferably, in step three, the reaction temperature is 25-60°C, the centrifugal speed is 3500-4000r / min, the centrifugal time is 15-20min, the vacuum drying temperature is 50-60°C, and the vacuum drying time is 12-24h.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows: the present invention adopts ion exchange and surface grafting to modify montmorillonite, improves the adsorption capacity of montmorillonite by ion exchange, introduces antibacterial and anti-inflammatory ions, mucosal repair substances, and hydrophobic groups by surface grafting to give montmorillonite multifunctionality, hydrophobic modification improves the stability of the suspension and reduces the adverse effects of organic additives on drug efficacy, and the antibacterial and mucosal repair functions improve the performance of the drug and expand the application field. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 The figure is a flow chart of the method of the present invention. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] Please see attached Figure 1 , a technical solution provided by the present invention:

[0022] Embodiment 1:

[0023] A montmorillonite suspension comprises: modified montmorillonite, a nonionic polymer suspending agent, a colorant, a fragrance, a sweetener and deionized water. The mass percentage content of each component is: 30% of modified montmorillonite, 1% of nonionic polymer suspending agent, 0.05% of colorant, 0.05% of fragrance and 0.1% of sweetener, and the balance is deionized water. The polymer suspending agent is preferably one of RC591, hydroxypropyl cellulose, xanthan gum, carrageenan and carbomer. The fragrance is one of apple flavor, strawberry flavor, lemon flavor and mint flavor. The sweetener is one of fructose and sucralose. The colorant is one of carotenoid, anthocyanin and caramel pigment.

[0024] A method for preparing a montmorillonite suspension comprises the following steps: first, weighing raw materials; second, ion exchange; third, graft modification; and fourth, mixing raw materials;

[0025] In the above step 1, based on the sum of the mass percentages of the components being 1, 75% of montmorillonite, 10% of an ion exchanger, 14% of a surface grafting monomer and 1% of an initiator are weighed, wherein the ion exchanger is hexadecyltrimethylammonium bromide, the surface grafting monomer is acrylic acid and N-vinylpyrrolidone, and the initiator is ammonium persulfate and sodium bisulfite;

[0026] In the above step 2, the montmorillonite weighed in step 1 is uniformly dispersed in deionized water, and then an ion exchanger is added, and the mixture is fully reacted at a temperature of 25-60° C., and the mixture is centrifuged at 2000-3500 r / min for 10-15 min to separate the solid, and then washed with deionized water for 3-5 times to remove the unreacted ion exchanger, thereby obtaining the montmorillonite after ion exchange;

[0027] In the above step 3, the montmorillonite after ion exchange in step 2 is taken, uniformly dispersed in deionized water, and then the surface grafting monomer is added. After uniform dispersion, an initiator is added, and the mixture is fully reacted at a temperature of 25-60° C., and centrifuged at 3500-4000 r / min for 15-20 min to separate the solid, and then washed with deionized water for 3-5 times to remove the unreacted ion exchanger, and vacuum dried to obtain the montmorillonite after ion exchange;

[0028] In the above step 4, raw materials are weighed according to the formula of montmorillonite suspension, and the raw materials are mixed evenly to obtain montmorillonite suspension.

[0029] Embodiment 2:

[0030] Referring to the formula and preparation method of Example 1, only the ion exchanger in step 1 is replaced with dodecyl dimethyl benzyl ammonium chloride, the surface grafting monomer is replaced with methyl methacrylate and acrylamide, and the initiator is replaced with azobisisobutyronitrile.

[0031] Embodiment 3:

[0032] Referring to the formula and preparation method of Example 1, only the ion exchanger in step 1 was replaced with octadecyltrimethylammonium chloride, the surface grafting monomer was replaced with itaconic acid and 2-hydroxyethyl methacrylate, and the initiator was replaced with benzoyl peroxide.

[0033] Embodiment 4:

[0034] Referring to the formula and preparation method of Example 1, only the ion exchanger in step 1 was replaced with tetrabutylammonium bromide, the surface grafting monomer was replaced with styrene and hydroxyethyl acrylate, and the initiator was replaced with benzoyl peroxide.

[0035] Embodiment 5:

[0036] Referring to the formula and preparation method of Example 1, only the ion exchanger in step 1 was replaced by silver nitrate, the surface grafting monomer was replaced by chitosan, and the initiator was replaced by glutaraldehyde.

[0037] The properties of each embodiment are compared in the following table:

[0038]

[0039] Based on the above, the present invention utilizes ion exchange combined with surface grafting to modify montmorillonite, introduces ions with antibacterial and anti-inflammatory properties, substances that promote intestinal mucosal repair, and hydrophobic groups, expands the montmorillonite interlayer spacing through ion exchange, increases internal adsorption sites, and enhances adsorption capacity. By surface grafting the montmorillonite after ion exchange, agglomeration is prevented, sedimentation is reduced, and multifunctionality is imparted. The stability of the suspension is improved by imparting hydrophobicity to the montmorillonite, while resisting the adverse effects of other organic additives on its performance. By imparting antibacterial properties and the ability to repair intestinal mucosa to montmorillonite, the functionality of the drug is enhanced, thereby broadening the scope of application.

[0040] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. A montmorillonite suspension, the formula comprising: Modified montmorillonite, nonionic polymer suspending agent, colorant, aromatic, sweetener and deionized water, characterized in that the mass percentage content of each component is: 25-35% of modified montmorillonite, 0.5-1.5% of nonionic polymer suspending agent, 0.01-0.1% of colorant, 0.01-0.1% of aromatic and 0.05-0.2% of sweetener, and the balance is deionized water.

2. A montmorillonite suspension according to claim 1, characterized in that: The mass percentage contents of the components are: 30% of modified montmorillonite, 1% of non-ionic polymer suspending agent, 0.05% of colorant, 0.05% of aromatic agent and 0.1% of sweetener, and the balance is deionized water.

3. A montmorillonite suspension according to claim 2, characterized in that: The polymer suspending agent is preferably one of RC591, hydroxypropyl cellulose, xanthan gum, carrageenan and carbomer.

4. A montmorillonite suspension according to claim 2, characterized in that: The aromatic agent is one of apple essence, strawberry essence, lemon essence and mint essence.

5. A montmorillonite suspension according to claim 2, characterized in that: The sweetener is one of fructose and sucralose, and the colorant is one of carotenoid, anthocyanin and caramel pigment.

6. A method for preparing a montmorillonite suspension, comprising step 1, weighing raw materials; step 2, ion exchange; step 3, graft modification; step 4, mixing raw materials; characterized in that: In the above step 1, based on the sum of the mass percentages of the components being 1, 75% of montmorillonite, 10% of ion exchanger, 14% of surface grafting monomer and 1% of initiator are weighed; In the above step 2, the montmorillonite weighed in step 1 is uniformly dispersed in deionized water, and then an ion exchanger is added. After sufficient reaction, the solid is separated by centrifugation, and then washed with deionized water for 3-5 times to remove the unreacted ion exchanger to obtain the montmorillonite after ion exchange; In the above step 3, the montmorillonite after ion exchange in step 2 is taken and evenly dispersed in deionized water, and then the surface grafting monomer is added, and the initiator is added after uniform dispersion. After sufficient reaction, the solid is separated by centrifugation, and then washed with deionized water for 3-5 times to remove the unreacted ion exchanger, and the montmorillonite after ion exchange is obtained after vacuum drying; In the above step 4, raw materials are weighed according to the formula of montmorillonite suspension, and the raw materials are mixed evenly to obtain montmorillonite suspension.

7. A method for preparing a montmorillonite suspension according to claim 6, characterized in that: In the step 1, the ion exchanger is one of hexadecyltrimethylammonium bromide, dodecyldimethylbenzylammonium chloride, octadecyltrimethylammonium chloride, tetrabutylammonium bromide and silver nitrate.

8. A method for preparing a montmorillonite suspension according to claim 6, characterized in that: In the step 1, the surface grafting monomer and the initiator are one of the following combinations: the surface grafting monomer is acrylic acid and N-vinyl pyrrolidone, and the initiator is ammonium persulfate and sodium bisulfite; the surface grafting monomer is methyl methacrylate and acrylamide, and the initiator is azobisisobutyronitrile; the surface grafting monomer is itaconic acid and 2-hydroxyethyl methacrylate, and the initiator is benzoyl peroxide; the surface grafting monomer is styrene and hydroxyethyl acrylate, and the initiator is benzoyl peroxide; the surface grafting monomer is chitosan, and the initiator is glutaraldehyde.

9. The method for preparing a montmorillonite suspension according to claim 6, characterized in that: In the step 2, the reaction temperature is 25-60°C, the centrifugal speed is 2000-3500r / min, and the centrifugal time is 10-15min.

10. The method for preparing a montmorillonite suspension according to claim 6, characterized in that: In the step 3, the reaction temperature is 25-60°C, the centrifugal speed is 3500-4000r / min, the centrifugal time is 15-20min, the vacuum drying temperature is 50-60°C, and the vacuum drying time is 12-24h.

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