Traditional Chinese medicine composition for treating orthopedic diseases as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating orthopedic diseases and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 50 to 100 parts of rhizoma drynariae, 50 to 100 parts of fructus psoraleae, 70 to 140 parts of radix astragali seu hedysari, 40 to 90 parts of radix paeoniae alba, 60 to 120 parts of radix angelicae sinensis, 60 to 120 parts of radix rehmanniae praeparata, 40 to 90 parts of herba cistanche, 20 to 50 parts of scorpio, 40 to 90 parts of pericarpium citri reticulatae, 40 to 90 parts of semen cuscutae, 40 to 90 parts of fructus lycii, 40 to 90 parts of radix dipsaci, 40 to 90 parts of rhizoma cibotii, 40 to 90 parts of rhizoma corydalis and 10 to 60 parts of liquorice root. The traditional Chinese medicine composition has a good treatment effect on osteoproliferation, osteoporosis and other related orthopedic diseases, and can effectively solve the problems existing in the prior art.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for treating orthopedic diseases, and a preparation method and application thereof. Background Art

[0002] Osteophyte is a common bone disease, the cause of which is mainly related to age and uneven stress on bones. With age, tissues such as articular cartilage and intervertebral discs will gradually degenerate. For example, articular cartilage will wear and thin, and the intervertebral discs between vertebrae will lose moisture and elasticity. In order to maintain the stability of the joints and spine, the body will increase the contact area and enhance support through bone hyperplasia. Long-term incorrect posture or excessive weight will cause the joints to bear abnormal pressure and stress distribution. Over time, bone hyperplasia is prone to occur at the edges of the joints. Bone hyperplasia can cause pain, nerve compression and other problems, seriously affecting the patient's normal life. At present, painkillers are generally used to relieve pain symptoms, and there is no targeted treatment plan.

[0003] Osteoporosis is a systemic bone disease characterized by low bone mass, destruction of bone microstructure, increased bone brittleness, and easy fractures. The main causes are endocrine factors, nutritional factors, lifestyle, and drugs. The main symptoms of osteoporosis are pain, spinal deformity, fractures, etc. At present, general parathyroid hormone drugs promote bone formation, but they are not easy to use for a long time. There are no targeted drugs on the market for the above bone diseases.

[0004] When bones are squeezed by external forces, fractures will occur, and it takes a long time for bones to heal. Generally, calcium supplements, anti-inflammatory agents, etc. are used to assist in increasing the healing speed of bones, but it still takes a long time, which greatly affects the patient's life. Summary of the invention

[0005] In view of the above-mentioned deficiencies in the prior art, the present invention provides a Chinese medicine composition for treating orthopedic diseases, and a preparation method and application thereof. The Chinese medicine composition has a good therapeutic effect on related orthopedic diseases such as bone hyperplasia and osteoporosis, and can effectively solve the problems existing in the prior art.

[0006] To achieve the above purpose, the technical solution adopted by the present invention to solve the technical problem is:

[0007] A traditional Chinese medicine composition for treating orthopedic diseases comprises the following components in parts by weight: 50-100 parts of drynaria rhizome, 50-100 parts of psoralea corylifolia, 70-140 parts of astragalus, 40-90 parts of white peony root, 60-120 parts of angelica sinensis, 60-120 parts of rehmannia root, 40-90 parts of cistanche deserticola, 20-50 parts of scorpion, 40-90 parts of tangerine peel, 40-90 parts of dodder seed, 40-90 parts of wolfberry, 40-90 parts of dipsaccharum officinale, 40-90 parts of citronella, 40-90 parts of corydalis and 10-60 parts of liquorice.

[0008] Further, the invention comprises the following components in parts by weight: 70-90 parts of Drynaria fortunei, 70-90 parts of Psoralea corylifolia, 100-120 parts of Astragalus membranaceus, 75-85 parts of White Peony Root, 90-110 parts of Angelica sinensis, 80-100 parts of Rehmannia glutinosa, 75-85 parts of Cistanche deserticola, 30-40 parts of Scorpio, 60-80 parts of Tangerine Peel, 60-80 parts of Cuscuta australis, 60-80 parts of Lycium barbarum, 60-80 parts of Dipsacus asper, 60-80 parts of Cibotium barbarum, 60-80 parts of Corydalis yanhusuo and 30-50 parts of Licorice.

[0009] Further, the invention comprises the following components in parts by weight: 70 parts of Drynaria fortunei, 90 parts of Psoralea corylifolia, 120 parts of Astragalus membranaceus, 85 parts of White Peony Root, 90 parts of Angelica sinensis, 100 parts of Rehmannia glutinosa, 75 parts of Cistanche deserticola, 30 parts of Scorpio, 60 parts of Tangerine Peel, 60 parts of Cuscuta australis, 60 parts of Lycium barbarum, 60 parts of Dipsacus asper, 80 parts of Cibotium barbarum, 80 parts of Corydalis yanhusuo and 30 parts of Licorice.

[0010] Further, the invention comprises the following components in parts by weight: 90 parts of Drynaria fortunei, 70 parts of Psoralea corylifolia, 100 parts of Astragalus membranaceus, 75 parts of White Peony Root, 110 parts of Angelica sinensis, 80 parts of Rehmannia glutinosa, 85 parts of Cistanche deserticola, 40 parts of Scorpio, 80 parts of Tangerine Peel, 80 parts of Cuscuta australis, 80 parts of Lycium barbarum, 80 parts of Dipsacus asper, 60 parts of Cibotium barbarum, 60 parts of Corydalis yanhusuo and 50 parts of Licorice.

[0011] Further, the invention comprises the following components in parts by weight: 80 parts of Drynaria fortunei, 80 parts of Psoralea corylifolia, 110 parts of Astragalus membranaceus, 80 parts of White Peony Root, 100 parts of Angelica sinensis, 90 parts of Rehmannia glutinosa, 80 parts of Cistanche deserticola, 35 parts of Scorpio, 70 parts of Tangerine Peel, 70 parts of Cuscuta australis, 70 parts of Lycium barbarum, 70 parts of Dipsacus asper, 70 parts of Cibotium barbarum, 70 parts of Corydalis yanhusuo and 40 parts of Licorice.

[0012] The preparation method of the above-mentioned Chinese medicine composition for treating orthopedic diseases includes the steps of crushing and mixing the raw materials; or mixing or extracting the raw materials separately to obtain an extract; or further refining and purifying the extract to obtain an effective ingredient; or adding pharmaceutically acceptable excipients to the extract / effective ingredient.

[0013] Furthermore, the dosage form is one of pills, granules, capsules, powders, mixtures, oral liquids or pastes.

[0014] Furthermore, the specific method includes: decocting the above-mentioned medicinal materials with water, filtering, collecting the filtrate, concentrating it into a clear paste, cooling it, adding ethanol thereto, letting it stand, filtering it, recovering the ethanol and then adding pharmaceutically acceptable excipients thereto, adjusting the pH value to weak acidity, and adding water to the standard amount to obtain the product.

[0015] Furthermore, the water is added and boiled twice, the first boiling time is 120 minutes, and the second boiling time is 60 minutes; after adding ethanol, the alcohol content in the solution reaches 45-70%.

[0016] Application of the above Chinese medicine composition in the preparation of medicines for treating orthopedic diseases.

[0017] The beneficial effects produced by the present invention are:

[0018] The herb Cistanche deserticola in the composition has the effects of nourishing the kidney and strengthening bones, promoting blood circulation and healing injuries, and the herb Psoralea corylifolia has the effects of warming the kidney and assisting yang, promoting qi intake and relieving asthma. The two herbs serve as the main drugs to achieve the effects of nourishing the kidney and strengthening bones, and fundamentally treat kidney deficiency and bone atrophy.

[0019] Astragalus has the effects of nourishing the kidney and raising yang, strengthening the body's defense system and strengthening the exterior. Qi can produce blood, and blood can nourish bones, which helps the main medicine to nourish the kidney; Angelica promotes blood circulation and replenishes blood, and Rehmannia root replenishes essence and nourishes marrow. The two are used together to play the effect of nourishing the liver and kidney essence and blood, and the liver and kidney essence and blood are replenished to nourish the bones. Scorpion removes wind and dredges the meridians, and Corydalis promotes qi and blood circulation. The two are used together to treat bone pain. The above together serve as ministers to assist the main medicine to improve the treatment effect.

[0020] White peony root has the effects of nourishing blood and restraining yin, relieving urgency and relieving pain, and can restrain the warm and dry nature of the main drug. Cistanche warms the kidney yang, wolfberry nourishes the kidney yin, and Cuscuta chinensis balances yin and yang, forming a balance of seeking yang in yin and seeking yin in yang. The three are used together to replenish both yin and yang. Tangerine peel has the effect of regulating qi and strengthening the spleen, which can prevent nourishing and greasy drugs such as Rehmannia glutinosa and Angelica sinensis from hindering the transportation and transformation of the spleen and stomach, and improve the absorption effect. Dipsacus has the effect of setting bones and tendons, and Cibotium barometz has the effect of strengthening waist tendons. The two guide the drug power directly to the waist and knees. The above drugs work as adjuvants and work synergistically, which can not only enhance the efficacy of the main and auxiliary drugs, but also eliminate side effects.

[0021] Licorice can harmonize the properties of medicines, relieve acute pain, alleviate the toxicity of scorpions, and reconcile the conflict between tonic medicines such as astragalus and rehmannia and the evil medicines of scorpions; it can also be used in combination with white peony root to enhance the analgesic effect.

[0022] In summary, the main drug of the composition in the present application focuses on strengthening bones, the auxiliary drug focuses on replenishing qi and blood and relieving pain, the adjuvant drug focuses on balancing the medicinal properties and guiding the drug to target, and the auxiliary drug focuses on enhancing efficacy and reducing toxicity. The above drugs work synergistically and have a good therapeutic effect on bone diseases. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical scheme and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention, that is, the embodiments described are only part of the embodiments of the present invention, rather than all of the embodiments.

[0024] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present invention.

[0025] It should be noted that relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprises" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0026] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0027] Example 1

[0028] A traditional Chinese medicine composition for treating orthopedic diseases is prepared from the following components in parts by weight: 50 parts of drynaria rhizome, 100 parts of psoralea corylifolia, 140 parts of astragalus, 90 parts of white peony root, 60 parts of angelica sinensis, 120 parts of rehmannia root, 40 parts of cistanche deserticola, 20 parts of scorpion, 40 parts of tangerine peel, 40 parts of dodder seed, 40 parts of wolfberry fruit, 40 parts of dipsaccharum officinale, 90 parts of citronella, 90 parts of corydalis and 10 parts of liquorice.

[0029] The preparation method of the above-mentioned Chinese medicine composition for treating orthopedic diseases comprises: adding water to the above-mentioned medicinal materials and boiling them for about 120 minutes for the first time and about 60 minutes for the second time, combining the decoctions, filtering, collecting the filtrate, concentrating it into a clear paste with a relative density of 1.02-1.1 (50° C.), cooling it, adding ethanol thereto so that the alcohol content reaches 45-70%, standing it, filtering it, recovering ethanol from the filtrate, adding pharmaceutically acceptable excipients thereto, adjusting the pH value to 6.5 with 10% sodium hydroxide solution, adding water to the standard, filtering, encapsulating, sterilizing, and obtaining the product.

[0030] Example 2

[0031] A traditional Chinese medicine composition for treating orthopedic diseases is prepared from the following components in parts by weight: 100 parts of drynaria rhizome, 50 parts of psoralea corylifolia, 70 parts of astragalus, 40 parts of white peony root, 120 parts of angelica sinensis, 60 parts of rehmannia root, 90 parts of cistanche deserticola, 50 parts of scorpion, 90 parts of tangerine peel, 90 parts of dodder seed, 90 parts of wolfberry fruit, 90 parts of dipsaccharum officinale, 40 parts of citronella, 40 parts of corydalis and 60 parts of liquorice.

[0032] The preparation method of the above-mentioned Chinese medicine composition for treating orthopedic diseases comprises: adding water to the above-mentioned medicinal materials and boiling them for about 120 minutes for the first time and about 60 minutes for the second time, combining the decoctions, filtering, collecting the filtrate, concentrating it into a clear paste with a relative density of 1.02-1.1 (50° C.), cooling it, adding ethanol thereto so that the alcohol content reaches 45-70%, standing it, filtering it, recovering ethanol from the filtrate, adding pharmaceutically acceptable excipients thereto, adjusting the pH value to 6.5 with 10% sodium hydroxide solution, adding water to the standard, filtering, encapsulating, sterilizing, and obtaining the product.

[0033] Example 3

[0034] A traditional Chinese medicine composition for treating orthopedic diseases is prepared from the following components in parts by weight: 70 parts of drynaria rhizome, 90 parts of psoralea corylifolia, 120 parts of astragalus, 85 parts of white peony root, 90 parts of angelica sinensis, 100 parts of rehmannia root, 75 parts of cistanche deserticola, 30 parts of scorpion, 60 parts of tangerine peel, 60 parts of dodder seed, 60 parts of wolfberry fruit, 60 parts of dipsaccharum officinale, 80 parts of citronella, 80 parts of corydalis and 30 parts of liquorice.

[0035] The preparation method of the above-mentioned Chinese medicine composition for treating orthopedic diseases comprises: adding water to the above-mentioned medicinal materials and boiling them for about 120 minutes for the first time and about 60 minutes for the second time, combining the decoctions, filtering, collecting the filtrate, concentrating it into a clear paste with a relative density of 1.02-1.1 (50° C.), cooling it, adding ethanol thereto so that the alcohol content reaches 45-70%, standing it, filtering it, recovering ethanol from the filtrate, adding pharmaceutically acceptable excipients thereto, adjusting the pH value to 6.5 with 10% sodium hydroxide solution, adding water to the standard, filtering, encapsulating, sterilizing, and obtaining the product.

[0036] Example 4

[0037] A traditional Chinese medicine composition for treating orthopedic diseases is prepared from the following components in parts by weight: 90 parts of drynaria rhizome, 70 parts of psoralea corylifolia, 100 parts of astragalus, 75 parts of white peony root, 110 parts of angelica sinensis, 80 parts of rehmannia root, 85 parts of cistanche deserticola, 40 parts of scorpion, 80 parts of tangerine peel, 80 parts of dodder seed, 80 parts of wolfberry fruit, 80 parts of dipsaccharum officinale, 60 parts of citronella, 60 parts of corydalis and 50 parts of liquorice.

[0038] The preparation method of the above-mentioned Chinese medicine composition for treating orthopedic diseases comprises: adding water to the above-mentioned medicinal materials and boiling them for about 120 minutes for the first time and about 60 minutes for the second time, combining the decoctions, filtering, collecting the filtrate, concentrating it into a clear paste with a relative density of 1.02-1.1 (50° C.), cooling it, adding ethanol thereto so that the alcohol content reaches 45-70%, standing it, filtering it, recovering ethanol from the filtrate, adding pharmaceutically acceptable excipients thereto, adjusting the pH value to 6.5 with 10% sodium hydroxide solution, adding water to the standard, filtering, encapsulating, sterilizing, and obtaining the product.

[0039] Example 5

[0040] A traditional Chinese medicine composition for treating orthopedic diseases is prepared from the following components in parts by weight: 80 parts of drynaria rhizome, 80 parts of psoralea corylifolia, 110 parts of astragalus, 80 parts of white peony root, 100 parts of angelica sinensis, 90 parts of rehmannia root, 80 parts of cistanche deserticola, 35 parts of scorpion, 70 parts of tangerine peel, 70 parts of dodder seed, 70 parts of wolfberry fruit, 70 parts of dipsaccharum officinale, 70 parts of citronella, 70 parts of corydalis and 40 parts of liquorice.

[0041] The preparation method of the above-mentioned Chinese medicine composition for treating orthopedic diseases comprises: adding water to the above-mentioned medicinal materials and boiling them for about 120 minutes for the first time and about 60 minutes for the second time, combining the decoctions, filtering, collecting the filtrate, concentrating it into a clear paste with a relative density of 1.02-1.1 (50° C.), cooling it, adding ethanol thereto so that the alcohol content reaches 45-70%, standing it, filtering it, recovering ethanol from the filtrate, adding pharmaceutically acceptable excipients thereto, adjusting the pH value to 6.5 with 10% sodium hydroxide solution, adding water to the standard, filtering, encapsulating, sterilizing, and obtaining the product.

[0042] Comparative Example 1

[0043] A traditional Chinese medicine composition for treating orthopedic diseases is prepared from the following components in parts by weight: 80 parts of drynaria rhizome, 80 parts of psoralea corylifolia, 110 parts of astragalus, 100 parts of angelica sinensis, 90 parts of rehmannia root, 80 parts of cistanche deserticola, 35 parts of centipede, 70 parts of tangerine peel, 70 parts of dodder seed, 70 parts of dipsaccharum officinale, 70 parts of citronella, 70 parts of corydalis and 40 parts of liquorice.

[0044] The preparation method of the above-mentioned Chinese medicine composition for treating orthopedic diseases comprises: adding water to the above-mentioned medicinal materials and boiling them for about 120 minutes for the first time and about 60 minutes for the second time, combining the decoctions, filtering, collecting the filtrate, concentrating it into a clear paste with a relative density of 1.02-1.1 (50° C.), cooling it, adding ethanol thereto so that the alcohol content reaches 45-70%, standing it, filtering it, recovering ethanol from the filtrate, adding pharmaceutically acceptable excipients thereto, adjusting the pH value to 6.5 with 10% sodium hydroxide solution, adding water to the standard, filtering, encapsulating, sterilizing, and obtaining the product.

[0045] Comparative Example 2

[0046] A traditional Chinese medicine composition for treating orthopedic diseases is prepared from the following components in parts by weight: 80 parts of drynaria rhizome, 80 parts of psoralea corylifolia, 110 parts of astragalus, 80 parts of white peony root, 100 parts of angelica sinensis, 90 parts of rehmannia root, 80 parts of epimedium, 35 parts of scorpion, 70 parts of tangerine peel, 70 parts of dodder seed, 70 parts of wolfberry, 70 parts of eucommia, 70 parts of mistletoe, 70 parts of corydalis and 40 parts of liquorice.

[0047] The preparation method of the above-mentioned Chinese medicine composition for treating orthopedic diseases comprises: adding water to the above-mentioned medicinal materials and boiling them for about 120 minutes for the first time and about 60 minutes for the second time, combining the decoctions, filtering, collecting the filtrate, concentrating it into a clear paste with a relative density of 1.02-1.1 (50° C.), cooling it, adding ethanol thereto so that the alcohol content reaches 45-70%, standing it, filtering it, recovering ethanol from the filtrate, adding pharmaceutically acceptable excipients thereto, adjusting the pH value to 6.5 with 10% sodium hydroxide solution, adding water to the standard, filtering, encapsulating, sterilizing, and obtaining the product.

[0048] Test example

[0049] 1. Patients with fractures (ulna and radius fractures, femoral shaft fractures, and supramalleolar fractures of the humerus) who came to the hospital for treatment, as well as patients diagnosed with osteoporosis, were randomly divided into 4 groups, namely the experimental group, control group 1, control group 2, and the blank group, with 40 people in each group, aged between 20 and 60 years old, with an average age of 51.2 years old.

[0050] 2. Treatment Methods

[0051] The patients in the experimental group took the medicine in Example 5, the patients in the control group 1 took the medicine in Comparative Example 1, and the patients in the control group 2 took the medicine in Comparative Example 2, 3 times a day, 20 ml each time, for 4 consecutive weeks. The blank group did not take any medicine, and the other treatments remained the same.

[0052] III. Efficacy evaluation criteria

[0053] (1) Fracture:

[0054] Cure: good alignment, continuous callus formation, no tenderness at the fracture end, no impact pain, and functional recovery;

[0055] Improvement: Alignment and position are acceptable, or fracture position is poor, but function is well recovered;

[0056] Unhealed: There is obvious local deformity of the fracture and some functional impairment.

[0057] Cure rate = number of cured people / total number of people*100%

[0058] (2) Osteoporosis:

[0059] Cure: Bone density returns to normal levels, pain disappears, and joint range of motion returns to normal;

[0060] Improvement: Bone density increased compared to before treatment, pain was relieved, and joint mobility increased;

[0061] Unhealed: Bone density changes are not obvious or continues to decrease, and pain and joint mobility have not improved significantly;

[0062] Effectiveness = (number of cured patients + number of improved patients) / total number of patients * 100%

[0063] IV. Results of efficacy evaluation

[0064] Table 1: Fracture treatment outcomes

[0065] Number of cured patients (persons) Improvement (people) Not cured (person) Cure rate (%) Experimental Group 22 18 0 55％ Control group 1 10 28 2 25％ Control group 2 8 29 3 20％ Blank group 3 15 22 7.5％

[0066] Table 2: Osteoporosis treatment results

[0067] Number of cured patients (persons) Improvement (people) Not cured (person) Effectiveness (%) Experimental Group 8 26 6 85％ Control group 1 4 16 20 50％ Control group 2 5 17 18 55％ Blank group 0 8 32 20％

[0068] It can be seen from the data in Table 1 and Table 2 that the drug in Example 5 has a good therapeutic effect on fractures and osteoporosis and can accelerate bone recovery; while the cure rate of fractures and the effective rate of osteoporosis in Comparative Examples 1 and 2 are significantly reduced. The reason may be that after adjusting the formula of the composition, the synergistic effect between the medicinal materials is weakened or disappears, which leads to a worse therapeutic effect on fractures and osteoporosis.

[0069] Clinical application found that this traditional Chinese medicine preparation has a good therapeutic effect on various bone and joint diseases such as bone and joint pain, lumbar disc herniation, muscle and bone strain, meniscus injury, etc.

[0070] Typical Cases

[0071] Case 1: Wang, female, 54 years old, underwent right proximal humeral fracture surgery in our hospital. After the surgery, she was asked to take the medicine in Example 5 for 2 consecutive weeks. The patient underwent X-ray review, which found that the fracture site was well aligned and a continuous bone girdle had been formed.

[0072] Case 2: Ms. Li, 62 years old, had low back and leg pain for more than a year. Testing showed that the patient was vitamin D deficient and had osteoporosis. She was asked to take the medicine in Example 5 and calcium supplements for 3 consecutive weeks. The patient reported in a follow-up examination that the low back and leg pain symptoms had disappeared. After taking the medicine for 2 weeks, the bone test results showed that the bone density had basically returned to normal.

[0073] Case 3: Mr. Li, male, 56 years old, reported right knee pain for more than a month. After examination, it was confirmed that he had meniscus injury. He was prescribed the medicine in Example 5. After taking it for 2 weeks, the patient reported that the pain symptoms disappeared and the joint movement was normal.

[0074] Case 4: Mr. Luo, a 61-year-old male, reported that he had pain in his left hip joint for more than half a year, with limited flexion and extension of the joint. He was diagnosed with arthralgia and was prescribed the medicine in Example 5. After taking the medicine for 4 weeks, he came to the hospital for treatment and reported that the pain had basically disappeared and the joint movement had returned to normal.

[0075] Case 5: Bi, female, 54 years old, had recurrent pain in her right knee for about half a year, accompanied by limited movement and slight swelling. She was diagnosed with meniscus injury and was prescribed the medicine in Example 5. After taking it for 4 weeks, she came to the hospital for a follow-up visit and said that the pain had basically disappeared and the joint movement had returned to normal.

[0076] Case 6: He, female, 45 years old, had recurrent pain in both knees for about 2 years and was diagnosed with patellar chondromalacia. She was prescribed the medicine in Example 5 and calcium supplements. After taking them for 4 weeks, she reported in a follow-up visit that the pain had disappeared and she could move freely.

[0077] Case 7: Guo Moumou, male, 71 years old, reported left shoulder blade pain for half a month. After examination, he was diagnosed with cervical spondylosis with osteoporosis. He was prescribed the medicine in Example 5. After taking it for 4 weeks, he was re-examined and reported that the pain disappeared.

Claims

1. A Chinese medicine composition for treating orthopedic diseases, characterized in that: The invention comprises the following components in parts by weight: 50-100 parts of drynaria rhizome, 50-100 parts of psoralea corylifolia, 70-140 parts of astragalus, 40-90 parts of white peony root, 60-120 parts of angelica sinensis, 60-120 parts of rehmannia root, 40-90 parts of cistanche deserticola, 20-50 parts of scorpion, 40-90 parts of tangerine peel, 40-90 parts of dodder seed, 40-90 parts of wolfberry, 40-90 parts of dipsaccharum officinale, 40-90 parts of citronella, 40-90 parts of corydalis and 10-60 parts of liquorice.

2. The Chinese medicine composition for treating orthopedic diseases according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 70-90 parts of drynaria rhizome, 70-90 parts of psoralea corylifolia, 100-120 parts of astragalus, 75-85 parts of white peony root, 90-110 parts of angelica sinensis, 80-100 parts of rehmannia root, 75-85 parts of cistanche deserticola, 30-40 parts of scorpion, 60-80 parts of tangerine peel, 60-80 parts of dodder seed, 60-80 parts of wolfberry, 60-80 parts of dipsaccharum officinale, 60-80 parts of citronella, 60-80 parts of corydalis and 30-50 parts of liquorice.

3. The Chinese medicine composition for treating orthopedic diseases according to claim 1 or 2, characterized in that: The invention comprises the following components in parts by weight: 70 parts of drynaria rhizome, 90 parts of psoralea corylifolia, 120 parts of astragalus, 85 parts of white peony root, 90 parts of angelica sinensis, 100 parts of rehmannia root, 75 parts of cistanche deserticola, 30 parts of scorpion, 60 parts of tangerine peel, 60 parts of dodder seed, 60 parts of wolfberry fruit, 60 parts of dipsaccharum officinale, 80 parts of citronella, 80 parts of yanhusuo and 30 parts of liquorice.

4. The Chinese medicine composition for treating orthopedic diseases according to claim 1 or 2, characterized in that: The invention comprises the following components in parts by weight: 90 parts of drynaria rhizome, 70 parts of psoralea corylifolia, 100 parts of astragalus, 75 parts of white peony root, 110 parts of angelica sinensis, 80 parts of rehmannia root, 85 parts of cistanche deserticola, 40 parts of scorpion, 80 parts of tangerine peel, 80 parts of dodder seed, 80 parts of wolfberry fruit, 80 parts of dipsaccharum officinale, 60 parts of citronella, 60 parts of yanhusuo and 50 parts of liquorice.

5. The Chinese medicine composition for treating orthopedic diseases according to claim 1 or 2, characterized in that: The invention comprises the following components in parts by weight: 80 parts of drynaria rhizome, 80 parts of psoralea corylifolia, 110 parts of astragalus, 80 parts of white peony root, 100 parts of angelica sinensis, 90 parts of rehmannia root, 80 parts of cistanche deserticola, 35 parts of scorpion, 70 parts of tangerine peel, 70 parts of dodder seed, 70 parts of wolfberry fruit, 70 parts of dipsaccharum officinale, 70 parts of citronella, 70 parts of corydalis and 40 parts of liquorice.

6. The method for preparing the Chinese medicine composition for treating orthopedic diseases according to any one of claims 1 to 5, characterized in that: It includes the steps of crushing and mixing the raw materials; or the extract obtained by mixing or extracting the raw materials separately; or the active ingredient obtained by further refining and purifying the extract; or the extract / active ingredient is added with pharmaceutically acceptable excipients.

7. The method for preparing the Chinese medicine composition for treating orthopedic diseases according to claim 6, characterized in that: The dosage form is one of pills, granules, capsules, powders, mixtures, oral liquids or pastes.

8. The method for preparing the Chinese medicine composition for treating orthopedic diseases according to claim 7, characterized in that: The specific method comprises: boiling the above medicinal materials with water, filtering, collecting the filtrate, concentrating it into a clear paste, cooling it, adding ethanol thereto, standing it, filtering it, recovering the ethanol, adding pharmaceutically acceptable excipients thereto, adjusting the pH value to weak acidity, and adding water to the standard amount to obtain the product.

9. The method for preparing the Chinese medicine composition for treating orthopedic diseases according to claim 8, characterized in that: The water is added and boiled for 2 times, the first boiling time is 120 minutes, and the second boiling time is 60 minutes; after adding ethanol, the alcohol content in the solution reaches 45-70%.

10. Use of the Chinese medicine composition according to claims 1-5 in preparing medicines for treating orthopedic diseases.