External Miao medicine for treating scalds and preparation method thereof

Abstract

The invention discloses an external Miao medicine for treating scalds and a preparation method thereof. The external Miao medicine is prepared from the following components in percentage by mass: 10 to 15 weight percent of red lead, 10 to 15 weight percent of garden burnet, 5 to 8 weight percent of golden cypress, 5 to 8 weight percent of rheum officinale, 10 to 15 weight percent of polygonum cuspidatum, 3 to 5 weight percent of myrrh, 3 to 5 weight percent of frankincense, 2 to 3 weight percent of borneol, 3 to 5 weight percent of coptis chinensis and the balance of tea seed oil. The preparation method comprises the following steps: preparing the red lead oil, pretreating the myrrh and the frankincense, soaking and decocting the medicinal materials, mixing and filtering, and adding the borneol, the Miao medicine takes the red lead, the sanguisorba officinalis, the golden cypress and other natural medicinal materials as main components, and has the effects of clearing away heat and toxic materials, relieving swelling and pain and promoting wound healing; the ointment is suitable for treating scalds, burns, skin ulcers, bedsores and the like. The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to an external Miao medicine for treating scalds and a preparation method thereof.

Description

Technical Field

[0001] The invention belongs to the field of Chinese medicine preparations, and specifically relates to an external Miao medicine for treating scalds and a preparation method thereof. Background Art

[0002] Burns are common skin injuries that can lead to infection, scars, and even functional impairment in severe cases. Currently, commonly used burn treatment drugs include silver sulfadiazine and burn ointment, but there are problems such as drug resistance, allergic reactions, and high prices. Traditional Miao medicine has gradually attracted attention because of its natural, safe, and effective characteristics.

[0003] In the prior art, CN102988389A discloses a Chinese medicine composition for treating burns, but its preparation process is complicated and does not solve the problem of low extraction rate of effective ingredients of medicinal materials. CN103893123B adopts supercritical CO2 extraction technology, which improves the extraction efficiency, but the equipment cost is high and difficult to promote. Summary of the invention

[0004] The technical problem to be solved by the invention is to prepare a traditional Chinese medicine which has the effects of clearing away heat and detoxifying, relieving swelling and relieving pain, and promoting wound healing, and has low production cost and simple preparation.

[0005] To solve the above problems, the technical solution adopted by the present invention is as follows: the external seedling medicine for treating burns proposed by the present invention comprises the following components in mass percentage: 10-15wt% of scutellaria baicalensis, 10-15wt% of sanguisorba officinalis, 5-8wt% of phellodendron amurense, 5-8wt% of rhubarb, 10-15wt% of knotweed, 3-5wt% of myrrh, 3-5wt% of frankincense, 2-3wt% of borneol, 3-5wt% of coptis chinensis and the balance of tea oil.

[0006] Furthermore, the radix scutellariae, radix sanguisorbae, cortex phellodendri, rhubarb, polygonum cuspidatum and coptis chinensis are all dry medicinal materials, and their water content is ≤8%.

[0007] Furthermore, the tea seed oil is cold-pressed virgin tea seed oil, with an acid value of 1.0 mgKOH / g and a peroxide value of ≤5.0 mmol / kg.

[0008] Furthermore, the myrrh and frankincense are in powder form with a particle size of ≤100 μm, and are extracted and purified by ethanol.

[0009] Furthermore, the borneol is natural borneol (dextrorotatory borneol) with a purity of ≥98%.

[0010] Furthermore, the preparation method of the external-use seedling medicine for treating burns comprises the following steps:

[0011] S1. Preparation of Zidan oil: Mix Zidan and tea seed oil in a mass ratio of 1:5, soak for 15 days, and filter to obtain Zidan oil;

[0012] S2. Pretreatment of myrrh and frankincense: crush myrrh and frankincense to a particle size of ≤100 μm, respectively, and extract and purify with ethanol;

[0013] S3. Soaking and boiling medicinal materials: Mix sanguisorba officinalis, phellodendron, rhubarb, knotweed and coptis chinensis with tea seed oil in a mass ratio of 1:10, soak for 15 days, and boil over medium heat for 20 minutes;

[0014] S4. Mixing and filtering: add myrrh powder, frankincense powder and purple red oil to the boiled oil, continue to boil for 5 minutes, and filter to obtain the oil;

[0015] S5. Adding borneol: Add borneol to the medicinal oil and stir until completely dissolved to obtain external seedling medicine.

[0016] Furthermore, the conditions for the ethanol extraction and purification are: ethanol concentration 75-85%, extraction temperature 60-70°C, and extraction time 2-3 hours.

[0017] Furthermore, the medium-heat cooking temperature is 80-90° C., and the stirring speed is 100-200 rpm.

[0018] The beneficial effects achieved by the present invention using the above structure are as follows:

[0019] 1. The topical seedling medicine for treating burns and its preparation method proposed in this scheme exert synergistic effects by scientifically proportioning medicinal materials such as purple dan, dandelion, and phellodendron; a method combining tea oil soaking and boiling is adopted to improve the extraction rate of effective ingredients; and the penetration-promoting effect of borneol is used to enhance the transdermal absorption effect of the drug.

[0020] 2. The external Miao medicine for treating burns and its preparation method proposed in this scheme optimize the ratio of medicinal materials and the preparation process. On the premise of ensuring the wound healing rate, analgesic effect and antibacterial properties of the external Miao medicine, the preparation method is simple and cost-controllable, and it is suitable for industrial production. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0022] The invention provides an external seedling medicine for treating burns, which comprises the following components in percentage by weight: 10-15wt% of radix scutellariae, 10-15wt% of sanguisorba officinalis, 5-8wt% of phellodendron amurense, 5-8wt% of rhubarb, 10-15wt% of knotweed, 3-5wt% of myrrh, 3-5wt% of frankincense, 2-3wt% of borneol, 3-5wt% of coptis chinensis and the balance of tea seed oil.

[0023] The scutellaria baicalensis, sanguisorba officinalis, phellodendron amurense, rhubarb, knotweed and coptis chinensis are all dry medicinal materials, and the water content thereof is ≤8%.

[0024] The tea seed oil is cold-pressed virgin tea seed oil, has an acid value of 1.0 mgKOH / g, and a peroxide value of ≤5.0 mmol / kg.

[0025] The myrrh and frankincense are in powder form with a particle size of ≤100 μm and are purified by ethanol extraction. The borneol is natural borneol (dextrorotatory borneol) with a purity of ≥98%.

[0026] The conditions for the ethanol extraction and purification are: ethanol concentration 75-85%, extraction temperature 60-70° C., and extraction time 2-3 hours.

[0027] The medium-fire cooking temperature is 80-90° C., and the stirring speed is 100-200 rpm.

[0028] The preparation method of the external Miao medicine for treating burns comprises the following detailed steps:

[0029] S1. Preparation of Zidan oil: Mix Zidan and tea seed oil in a mass ratio of 1:5, soak for 15 days, and filter to obtain Zidan oil;

[0030] S2. Pretreatment of myrrh and frankincense: crush myrrh and frankincense to a particle size of ≤100 μm, extract with 75% ethanol at 65°C for 2.5 hours, filter and dry;

[0031] S3. Soaking and boiling medicinal materials: Mix Sanguisorba officinalis, Phellodendron amurense, Rhubarb, Polygonum cuspidatum and Coptis chinensis with tea seed oil in a mass ratio of 1:10, soak for 15 days, and boil at medium heat at 85°C for 20 minutes;

[0032] S4. Mixing and filtering: add myrrh powder, frankincense powder and purple red oil to the boiled oil, continue to boil for 5 minutes, and filter to obtain the oil;

[0033] S5. Adding borneol: Add borneol to the medicinal oil and stir until completely dissolved to obtain external seedling medicine.

[0034] The following are the ratios and performance test results of three typical embodiments:

[0035] Table 1: Proportions of Examples

[0036]

[0037] Performance test results:

[0038] Wound healing rate (%): Example 1 (95), Example 2 (90), Example 3 (98);

[0039] Analgesic effect (VAS score): Example 1 (2.5), Example 2 (3.0), Example 3 (2.0);

[0040] Antibacterial rate (%): Example 1 (99), Example 2 (97), Example 3 (99.5).

[0041] Example 3 showed the best wound healing rate and antibacterial rate due to its high content of borneol and chrysanthemum, which verified the effectiveness of the optimized ratio.

[0042] The present invention and its implementation methods are described above, and such description is not restrictive, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design structures and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. An external-use seedling medicine for treating burns, characterized in that: The invention comprises the following components in percentage by weight: 10-15wt% of Radix Glehniae, 10-15wt% of Radix Sanguisorbae, 5-8wt% of Phellodendron chinense, 5-8wt% of Radix Rhei, 10-15wt% of Polygonum Cuspidatum, 3-5wt% of Myrrh, 3-5wt% of Frankincense, 2-3wt% of Borneol, 3-5wt% of Coptis Chinensis and the balance of Camellia Oil.

2. The external-use seedling medicine for treating burns according to claim 1, characterized in that: The scutellaria baicalensis, sanguisorba officinalis, phellodendron amurense, rhubarb, knotweed and coptis chinensis are all dry medicinal materials, and the water content thereof is ≤8%.

3. The external-use seedling medicine for treating burns according to claim 2, characterized in that: The tea seed oil is cold-pressed virgin tea seed oil, has an acid value of 1.0 mgKOH / g, and a peroxide value of ≤5.0 mmol / kg.

4. The external-use seedling medicine for treating burns according to claim 3, characterized in that: The myrrh and frankincense are in powder form with a particle size of ≤100 μm and are extracted and purified by ethanol.

5. The external-use seedling medicine for treating burns and its preparation method according to claim 4, characterized in that: The borneol is natural borneol (dextrorotatory borneol) with a purity of ≥98%.

6. A method for preparing an external seedling medicine for treating burns according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1. Preparation of Zidan oil: Mix Zidan and tea seed oil in a mass ratio of 1:5, soak for 15 days, and filter to obtain Zidan oil; S2. Pretreatment of myrrh and frankincense: crush myrrh and frankincense to a particle size of ≤100 μm, respectively, and extract and purify with ethanol; S3. Soaking and boiling medicinal materials: Mix sanguisorba officinalis, phellodendron, rhubarb, knotweed and coptis chinensis with tea seed oil in a mass ratio of 1:10, soak for 15 days, and boil over medium heat for 20 minutes; S4. Mixing and filtering: add myrrh powder, frankincense powder and purple red oil to the boiled oil, continue to boil for 5 minutes, and filter to obtain the oil; S5. Adding borneol: Add borneol to the medicinal oil and stir until completely dissolved to obtain external seedling medicine.

7. The preparation method according to claim 6, characterized in that: The conditions for the ethanol extraction and purification are: ethanol concentration 75-85%, extraction temperature 60-70° C., and extraction time 2-3 hours.

8. The preparation method according to claim 7, characterized in that: The medium-fire cooking temperature is 80-90° C., and the stirring speed is 100-200 rpm.

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