Medicine for treating femoral head necrosis and bone fiber abnormal proliferation and preparation method thereof

Abstract

The invention discloses a medicine for treating femoral head necrosis and abnormal bone fiber proliferation and a preparation method thereof. The medicine is prepared from the following traditional Chinese medicines in percentage by weight: 5-13% of American ginseng, 5-15% of donkey-hide gelatin, 4-14% of deer glue, 5-15% of pseudo-ginseng, 5-10% of astragalus membranaceus, 10-18% of elderberry, 6-15% of radix paeoniae rubra, 6-10% of bighead atractylodes rhizome, 7-17% of ligusticum wallichii, 5-9% of angelica sinensis, 6-12% of rhizoma drynariae, 6-10% of teasel root, 5-9% of herba epimedii and 4-8% of stigma croci. The traditional Chinese medicine composition has a good effect on non-healing fracture, pathological fracture and old separation fracture after fracture. Especially, the cancerometastasis osteolytic osteolysis damage and bone fiber abnormal proliferation disease ceiling level difficulty is caused because the disease shows that multiple bone substances in the whole body are damaged, western medicine only depends on bone grafting treatment, and due to the fact that the damage range is large, the grafted bone is difficult to survive, and the fundamental problems cannot be solved. The medicine for treating femoral head necrosis and bone fiber abnormal proliferation can repair and fuse osteonecrosis, and the cure rate is extremely high.

Description

Technical Field

[0001] The invention relates to the technical field of drugs for promoting bone regeneration, and in particular to drugs for treating femoral head necrosis and fibrous dysplasia and a preparation method thereof. Background Art

[0002] Femoral head necrosis is caused by interruption or damage to the blood supply to the femoral head blood vessels, leading to the death of bone cells and bone marrow components and subsequent repair, further causing changes in the femoral head structure and collapse of bone tissue, which in turn leads to symptoms such as femoral head bone destruction, pain around the hip joint, and decreased or loss of joint function. It is a common and intractable disease.

[0003] Fracture is one of the common clinical diseases, which is caused by internal and external factors. External injuries include direct violence, indirect violence, strong muscle contraction, continuous strain, etc.; internal injuries include age, physical constitution, anatomical structure, pathological factors, congenital factors, infection by evil toxins, and internal injuries caused by the seven emotions.

[0004] Osteonecrosis, fibrous dysplasia, nonunion after fracture, bone cyst, and osteolytic destruction caused by cancer metastasis are all problems that the world's medical science has not yet overcome. Currently, there is no good solution for fibrous dysplasia, and it is necessary to develop drugs that can treat fibrous dysplasia. Summary of the invention

[0005] The purpose of the present invention is to provide a medicine for treating femoral head necrosis and fibrous dysplasia and a preparation method thereof, so as to solve the technical problem that the existing technology has poor effects after replacing traditional Chinese and Western medicine for treatment.

[0006] To achieve the above object, the present invention provides the following technical solutions: The medicine for treating femoral head necrosis and fibrous dysplasia provided by the present invention is composed of the following Chinese medicines in percentage by weight: 5-13% American ginseng, 5-15% donkey-hide gelatin, 4-14% deer glue, 5-15% Panax notoginseng, 5-10% astragalus, 10-18% elderberry, 6-15% red peony root, 6-10% atractylodes, 7-17% ligusticum, 5-9% angelica, 6-12% drynaria, 6-10% dipsaccharum, 5-9% epimedium and 4-8% saffron.

[0007] Furthermore, it is composed of the following Chinese medicinal herbs in weight percentage: 5% American ginseng, 5% donkey-hide gelatin, 4% deer glue, 15% Panax notoginseng, 5% Astragalus, 10% Elderberry, 6% Red Peony Root, 6% Atractylodes, 17% Ligusticum chuanxiong, 5% Angelica, 6% Drynaria, 6% Dipsacus, 6% Epimedium, and 4% Crocus.

[0008] Furthermore, it is composed of the following Chinese medicinal herbs in weight percentage: 13% American ginseng, 5% donkey-hide gelatin, 4% deer glue, 5% Panax notoginseng, 5% Astragalus, 10% Elderberry, 6% Red Peony Root, 6% Atractylodes, 7% Chuanxiong, 5% Angelica, 6% Drynaria, 6% Dipsacus, 5% Epimedium, and 4% Saffron.

[0009] Furthermore, it is composed of the following Chinese medicinal herbs in weight percentage: 10% American ginseng, 9% donkey-hide gelatin, 8% deer glue, 10% Panax notoginseng, 7% Astragalus, 15% Elderberry, 12% Red Peony Root, 7% Atractylodes, 12% Ligusticum chuanxiong, 6% Angelica, 6% Drynaria, 8% Dipsacus, 7% Epimedium, and 7% Saffron.

[0010] The present invention also provides a method for preparing a drug for treating femoral head necrosis and fibrous dysplasia of bone, comprising taking the Chinese medicinal components according to weight proportions, soaking and boiling them in water for three times, and preparing clinically acceptable powders, tablets, granules, capsules, mixtures, pills or injections according to conventional processes.

[0011] Furthermore, American ginseng, donkey-hide gelatin, deer glue, Panax notoginseng, astragalus, elderberry, red peony root, Atractylodes macrocephala, Ligusticum chuanxiong, Angelica sinensis, Drynaria fortunei, Dipsacus asper, Epimedium, and saffron are taken in proportion by weight, soaked and boiled three times in water, the obtained medicinal liquid is mixed and concentrated into an extract, and spray-dried and granulated.

[0012] Further, the soaking and boiling with water specifically comprises: S1. First extraction: add 8 times water, soak for 30 minutes, heat to boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep boiling for 1.5 hours, the extraction is completed, the liquid is filtered through a 120-mesh screen, pumped into a storage tank, measured, and the residue is left in the tank waiting for the second extraction; S2. Second extraction: add 5 times water, heat to slight boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep slight boiling for 1.5 hours, the extraction is completed, the drug solution is filtered through a 120-mesh sieve, pumped into a storage tank, measured, and the drug residue is discharged from the tank.

[0013] Furthermore, the concentration is specifically as follows: using a double-effect concentrator for concentration, the temperature and vacuum degree of the double-effect concentrator are controlled respectively: 80~90℃, -0.04~-0.06MPa for the first effect; 70~80℃, -0.06~-0.08Mpa for the second effect, when concentrated to a relative density of 1.28-1.35, the vacuum is removed to collect the extract.

[0014] Furthermore, the granulation conditions are: controlling the granulator inlet air temperature: 45~90°C; outlet air temperature: 40~85°C; material temperature: 60~80°C; drying time: 90-120 minutes, and discharging the material when the moisture content is ≤4.0%.

[0015] The present invention adds American ginseng, which has the effects of invigorating qi and nourishing yin, improving the spirit of human body and enhancing the resistance of human body.

[0016] Astragalus has the effect of replenishing qi and raising yang, replenishing the body's positive energy and enhancing the body's resistance.

[0017] Elderberry can promote fracture healing and help bone recovery.

[0018] Atractylodes can strengthen the spleen and replenish qi, enhance the function of the spleen and stomach, and promote the spleen and stomach to transport and transform the essence of water and grain.

[0019] Chuanxiong can promote blood circulation, remove blood stasis, promote qi circulation, and make qi flow smoothly. It can effectively improve blood stasis.

[0020] Orthopedic diseases such as femoral head necrosis and fractures are chronic diseases, which often develop from 1 to 20 years. Because they are difficult to cure and take a long time, they consume human qi and blood, and the body is relatively weak. The present invention treats bone necrosis on the basis of tonifying the liver and kidney, tonifying qi and blood, and regulating the spleen and stomach. The kidney is the innate foundation, and the spleen is the acquired foundation. Only when the spleen and stomach can function normally can nutrients be continuously supplied to the liver and kidney. When the liver and kidney are strong, the bones are filled, and when the qi and blood are sufficient, the body is strong, and the disease recovery is fast.

[0021] The combination of the above ingredients nourishes the liver and kidneys, replenishes qi and blood, regulates the spleen and stomach, and together enhances the body's immune function, dilates blood vessels, enhances blood circulation, improves blood rheology, rebuilds microcirculation, and repairs necrotic bone.

[0022] Based on the above technical solution, the embodiments of the present invention can at least produce the following technical effects: (1) The present invention provides a drug and preparation method for treating femoral head necrosis and fibrous dysplasia. For adult femoral head necrosis, the drug can repair the necrotic cyst and fragments. After recovery, the patient can walk continuously for 15 to 20 kilometers and can carry a weight of 60 to 100 kilograms.

[0023] (2) The present invention provides a drug and preparation method for treating femoral head necrosis and fibrous dysplasia. For children with femoral head necrosis, the drug will not cause disability after being cured and will not affect their growth and development.

[0024] (3) The present invention provides a drug and preparation method for treating femoral head necrosis and fibrous dysplasia, which has good effects on non-union after fracture, pathological fracture, and old separation fracture. In particular, osteolytic destruction of cancer metastasis and fibrous dysplasia are difficult to treat because the disease presents multiple bone destructions throughout the body. Western medicine only relies on bone grafting for treatment. Due to the large range of destruction, the bone graft is difficult to survive and cannot solve the fundamental problem. The present invention provides a drug for treating femoral head necrosis and fractures that are difficult to heal, which can repair and fuse bone necrosis and has a very high cure rate. DETAILED DESCRIPTION

[0025] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0026] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0027] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0028] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to the skilled artisan. The present invention description and examples are exemplary only.

[0029] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0030] The present invention adds American ginseng, which has the effects of invigorating qi and nourishing yin, improving the spirit of human body and enhancing the resistance of human body.

[0031] Astragalus has the effect of replenishing qi and raising yang, replenishing the body's positive energy and enhancing the body's resistance.

[0032] Elderberry can promote fracture healing and help bone recovery.

[0033] Atractylodes can strengthen the spleen and replenish qi, enhance the function of the spleen and stomach, and promote the spleen and stomach to transport and transform the essence of water and grain.

[0034] Chuanxiong can promote blood circulation, remove blood stasis, promote qi circulation, and make qi flow smoothly. It can effectively improve blood stasis.

[0035] Orthopedic diseases such as femoral head necrosis and fractures are chronic diseases, which often develop from 1 to 20 years. Because they are difficult to cure and take a long time, they consume human qi and blood, and the body is relatively weak. The present invention treats bone necrosis on the basis of tonifying the liver and kidney, tonifying qi and blood, and regulating the spleen and stomach. The kidney is the innate foundation, and the spleen is the acquired foundation. Only when the spleen and stomach can function normally can nutrients be continuously supplied to the liver and kidney. When the liver and kidney are strong, the bones are filled, and when the qi and blood are sufficient, the body is strong, and the disease recovery is fast.

[0036] Example 1

[0037] The invention provides a medicine for treating femoral head necrosis and fibrous dysplasia of bone and a preparation method thereof. The medicine is composed of the following Chinese medicines in percentage by weight: 5-13% of American ginseng, 5-15% of donkey-hide gelatin, 4-14% of deer glue, 5-15% of Panax notoginseng, 5-10% of astragalus, 10-18% of elderberry, 6-15% of red peony root, 6-10% of atractylodes macrocephala, 7-17% of chuanxiong, 5-9% of angelica, 6-12% of drynaria, 6-10% of dipsaccharum officinale, 5-9% of epimedium, and 4-8% of saffron Take American ginseng, donkey-hide gelatin, deer glue, Panax notoginseng, astragalus, elderberry, red peony root, white atractylodes, ligusticum chuanxiong, angelica, drynaria, dipsaccharum, epimedium, and saffron according to weight proportion, soak and boil them in water for three times, mix the obtained medicinal liquid evenly, concentrate it into an extract, and spray dry it into granules.

[0038] The soaking and boiling with water specifically comprises: S1. First extraction: add 8 times water, soak for 30 minutes, heat to boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep boiling for 1.5 hours, the extraction is completed, the liquid is filtered through a 120-mesh screen, pumped into a storage tank, measured, and the residue is left in the tank waiting for the second extraction; S2. Second extraction: add 5 times water, heat to slight boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep slight boiling for 1.5 hours, the extraction is completed, the drug solution is filtered through a 120-mesh sieve, pumped into a storage tank, measured, and the drug residue is discharged from the tank.

[0039] The concentration is specifically as follows: using a double-effect concentrator for concentration, the temperature and vacuum degree of the double-effect concentrator are controlled respectively: 80-90°C and -0.04-0.06MPa for the first effect; 70-80°C and -0.06-0.08Mpa for the second effect, and when the relative density reaches 1.28-1.35, the vacuum is discharged to collect the extract.

[0040] The granulation conditions are as follows: control the granulator air inlet temperature: 45-90°C; air outlet temperature: 40-85°C; material temperature: 60-80°C; drying time: 90-120 minutes, and discharge the material when the moisture content is ≤4.0%.

[0041] Example 2

[0042] The invention provides a medicine for treating femoral head necrosis and fibrous dysplasia of bone and a preparation method thereof. The medicine is composed of the following Chinese medicines in percentage by weight: 5% American ginseng, 5% donkey-hide gelatin, 4% deer glue, 15% Panax notoginseng, 5% Astragalus, 10% Elderberry, 6% Red Peony Root, 6% Atractylodes, 17% Chuanxiong, 5% Angelica, 6% Drynaria, 6% Dipsacus, 5% Epimedium and 4% Crocus.

[0043] Take American ginseng, donkey-hide gelatin, deer glue, Panax notoginseng, astragalus, elderberry, red peony root, white atractylodes, ligusticum chuanxiong, angelica, drynaria, dipsaccharum, epimedium, and saffron according to weight proportion, soak and boil them in water for three times, mix the obtained medicinal liquid evenly, concentrate it into an extract, and spray dry it into granules.

[0044] The soaking and boiling with water specifically comprises: S1. First extraction: add 8 times water, soak for 30 minutes, heat to boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep boiling for 1.5 hours, the extraction is completed, the liquid is filtered through a 120-mesh screen, pumped into a storage tank, measured, and the residue is left in the tank waiting for the second extraction; S2. Second extraction: add 5 times water, heat to slight boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep slight boiling for 1.5 hours, the extraction is completed, the drug solution is filtered through a 120-mesh sieve, pumped into a storage tank, measured, and the drug residue is discharged from the tank.

[0045] The concentration is specifically as follows: using a double-effect concentrator for concentration, the temperature and vacuum degree of the double-effect concentrator are controlled respectively: 80-90°C and -0.04-0.06MPa for the first effect; 70-80°C and -0.06-0.08Mpa for the second effect, and when the relative density reaches 1.28-1.35, the vacuum is discharged to collect the extract.

[0046] The granulation conditions are as follows: control the granulator air inlet temperature: 45-90°C; air outlet temperature: 40-85°C; material temperature: 60-80°C; drying time: 90-120 minutes, and discharge the material when the moisture content is ≤4.0%.

[0047] Example 3

[0048] The invention provides a medicine for treating femoral head necrosis and fibrous dysplasia of bone and a preparation method thereof. The medicine is composed of the following Chinese medicinal materials in percentage by weight: 13% American ginseng, 5% donkey-hide gelatin, 4% deer glue, 5% Panax notoginseng, 5% astragalus, 10% elderberry, 6% red peony root, 6% atractylodes, 7% ligusticum, 5% angelica, 6% drynaria, 6% dipsacus, 5% epimedium and 4% saffron.

[0049] Take American ginseng, donkey-hide gelatin, deer glue, Panax notoginseng, astragalus, elderberry, red peony root, white atractylodes, ligusticum chuanxiong, angelica, drynaria, dipsaccharum, epimedium, and saffron according to weight proportion, soak and boil them in water for three times, mix the obtained medicinal liquid evenly, concentrate it into an extract, and spray dry it into granules.

[0050] The soaking and boiling with water specifically comprises: S1. First extraction: add 8 times water, soak for 30 minutes, heat to boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep boiling for 1.5 hours, the extraction is completed, the liquid is filtered through a 120-mesh screen, pumped into a storage tank, measured, and the residue is left in the tank waiting for the second extraction; S2. Second extraction: add 5 times water, heat to slight boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep slight boiling for 1.5 hours, the extraction is completed, the drug solution is filtered through a 120-mesh sieve, pumped into a storage tank, measured, and the drug residue is discharged from the tank.

[0051] The concentration is specifically as follows: using a double-effect concentrator for concentration, the temperature and vacuum degree of the double-effect concentrator are controlled respectively: 80-90°C and -0.04-0.06MPa for the first effect; 70-80°C and -0.06-0.08Mpa for the second effect, and when the relative density reaches 1.28-1.35, the vacuum is discharged to collect the extract.

[0052] The granulation conditions are as follows: control the granulator air inlet temperature: 45-90°C; air outlet temperature: 40-85°C; material temperature: 60-80°C; drying time: 90-120 minutes, and discharge the material when the moisture content is ≤4.0%.

[0053] Example 4

[0054] The invention provides a medicine for treating femoral head necrosis and fibrous dysplasia of bone and a preparation method thereof. The medicine is composed of the following Chinese medicinal materials in percentage by weight: 10% American ginseng, 9% donkey-hide gelatin, 8% deer glue, 10% notoginseng, 7% astragalus, 15% elderberry, 12% red peony root, 7% atractylodes, 12% ligusticum chuanxiong, 6% angelica, 6% drynaria, 8% dipsaccharum, 7% epimedium and 7% saffron.

[0055] Take American ginseng, donkey-hide gelatin, deer glue, Panax notoginseng, astragalus, elderberry, red peony root, white atractylodes, ligusticum chuanxiong, angelica, drynaria, dipsaccharum, epimedium, and saffron according to weight proportion, soak and boil them in water for three times, mix the obtained medicinal liquid evenly, concentrate it into an extract, and spray dry it into granules.

[0056] The soaking and boiling with water specifically comprises: S1. First extraction: add 8 times water, soak for 30 minutes, heat to boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep boiling for 1.5 hours, the extraction is completed, the liquid is filtered through a 120-mesh screen, pumped into a storage tank, measured, and the residue is left in the tank waiting for the second extraction; S2. Second extraction: add 5 times water, heat to slight boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep slight boiling for 1.5 hours, the extraction is completed, the drug solution is filtered through a 120-mesh sieve, pumped into a storage tank, measured, and the drug residue is discharged from the tank.

[0057] The concentration is specifically as follows: using a double-effect concentrator for concentration, the temperature and vacuum degree of the double-effect concentrator are controlled respectively: 80-90°C and -0.04-0.06MPa for the first effect; 70-80°C and -0.06-0.08Mpa for the second effect. When the relative density reaches 1.28-1.35, the vacuum is discharged to collect the extract.

[0058] The granulation conditions are as follows: control the granulator air inlet temperature: 45-90°C; air outlet temperature: 40-85°C; material temperature: 60-80°C; drying time: 90-120 minutes, and discharge the material when the moisture content is ≤4.0%.

[0059] Case Case 1: Adult femoral head necrosis, male patient, 39 years old The patient suffered from stage IV femoral head necrosis due to taking painkillers. The right femoral head was broken into several fragments on the outside. A 2x0.8cm longitudinal cystic area was seen on the outside of the left femoral head, and the rest was fragmented. After 10+ months of treatment, both femoral heads were basically repaired.

[0060] Case 2: Femoral head necrosis in children, male patient, 7 years old The patient had necrosis of the right femoral head, collapse and flattening of the right femoral head, and destruction of the epiphysis into small fragments. Treatment for more than a year was ineffective. After treatment with the drug of the present invention, the original fragments were repaired, the femoral head grew taller and rounder, and the recovery was better.

[0061] Case 3: Fibrous dysplasia of bone, female patient, 21 years old The patient had "left femoral fibrous dysplasia" and underwent bone grafting, but the treatment effect was not good. Before the treatment, the patient walked with crutches and had difficulty walking. The film showed that the bone graft below the femoral neck did not survive after the surgery, the left femur and femoral neck were mostly destroyed, the bone became thinner, and the upper part of the femur was slightly expanded and thickened, showing ground-glass changes. After more than 3 years of treatment, the damaged bone was basically repaired, the femoral shaft bone thickened, and the patient walked normally with moderate weight bearing.

[0062] Case 4: Female patient, 71 years old CR film showed right femoral neck fracture with separation of 0.3cm, femoral neck absorbed, greater trochanter shifted upward 1.5CM. After 5 months of drug treatment of the present invention, the patient was cured. DR film showed: the gap of the original separation had been filled, the fracture line was blurred, the trabeculae had passed through the fracture line, and the whole body osteoporosis was significantly improved. The patient could walk 2-3km without crutches, and the right hip joint did not feel pain.

[0063] Finally, it should be noted that: The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that the technical solutions described in the above embodiments may still be modified, or some or all of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A drug for treating femoral head necrosis and fibrous dysplasia, characterized in that: The invention is composed of the following Chinese medicinal materials in percentage by weight: 5-13% American ginseng, 5-15% donkey-hide gelatin, 4-14% deer glue, 5-15% Panax notoginseng, 5-10% astragalus, 10-18% elderberry, 6-15% red peony root, 6-10% atractylodes, 7-17% ligusticum, 5-9% angelica, 6-12% drynaria, 6-10% dipsaccharum, 5-9% epimedium and 4-8% saffron.

2. The drug for treating femoral head necrosis and fibrous dysplasia according to claim 1, characterized in that: The composition is composed of the following Chinese medicinal materials in percentage by weight: 5% American ginseng, 5% donkey-hide gelatin, 4% deer glue, 15% Panax notoginseng, 5% Astragalus, 10% Elderberry, 6% Red Peony Root, 6% Atractylodes, 17% Ligusticum chuanxiong, 5% Angelica, 6% Drynaria, 6% Dipsacus asper, 5% Epimedium, and 4% Saffron.

3. The drug for treating femoral head necrosis and fibrous dysplasia according to claim 1, characterized in that: The composition is composed of the following Chinese medicinal materials in percentage by weight: 13% American ginseng, 5% donkey-hide gelatin, 4% deer glue, 5% Panax notoginseng, 5% Astragalus, 10% Elderberry, 6% Red Peony Root, 6% Atractylodes, 7% Chuanxiong, 5% Angelica, 6% Drynaria, 6% Dipsacus, 5% Epimedium, and 4% Saffron.

4. The drug for treating femoral head necrosis and fibrous dysplasia according to claim 1, characterized in that: The composition is composed of the following Chinese medicinal materials in percentage by weight: 10% American ginseng, 9% donkey-hide gelatin, 8% deer glue, 10% Panax notoginseng, 7% Astragalus, 15% Elderberry, 12% Red Peony Root, 7% Atractylodes, 12% Ligusticum chuanxiong, 6% Angelica, 6% Drynaria, 8% Dipsacus, 7% Epimedium, and 7% Saffron.

5. The method for preparing the medicine for treating femoral head necrosis and fibrous dysplasia according to any one of claims 1 to 4, characterized in that: The Chinese medicinal components are taken in proportion by weight, soaked and boiled in water, and prepared into clinically acceptable powders, tablets, granules, capsules, mixtures, pills or injections according to conventional processes.

6. The method for preparing the medicine for treating femoral head necrosis and fibrous dysplasia according to claim 5, characterized in that: Take American ginseng, donkey-hide gelatin, deer glue, Panax notoginseng, astragalus, elderberry, red peony root, white atractylodes, ligusticum chuanxiong, angelica, drynaria, dipsaccharum, epimedium and saffron according to weight proportion, soak and boil with water, mix the obtained medicinal liquid evenly and concentrate it into extract, and spray dry and granulate it.

7. The method for preparing the medicine for treating femoral head necrosis and fibrous dysplasia according to claim 6, characterized in that: The soaking and boiling with water is specifically as follows: S1. First extraction: add 8 times water, soak for 30 minutes, heat to boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep slightly boiling for 1.5 hours, the extraction is completed, the liquid is filtered through a 120-mesh screen, pumped into a storage tank, measured, and the residue is left in the tank waiting for the second extraction; S2. Second extraction: add 5 times water, heat to slight boiling, control the interlayer steam pressure below 0.1Mpa, the temperature at 98~102℃, keep slight boiling for 1.5 hours, the extraction is completed, the drug solution is filtered through a 120-mesh sieve, pumped into a storage tank, measured, and the drug residue is discharged from the tank.

8. The method for preparing the medicine for treating femoral head necrosis and fibrous dysplasia according to claim 6, characterized in that: The concentration is specifically as follows: using a double-effect concentrator for concentration, the temperature and vacuum degree of the double-effect concentrator are controlled respectively: 80-90°C and -0.04-0.06MPa for the first effect; 70-80°C and -0.06-0.08Mpa for the second effect, and when the relative density reaches 1.28-1.35, the vacuum is discharged to collect the extract.

9. The method for preparing the medicine for treating femoral head necrosis and fibrous dysplasia according to claim 6, characterized in that: The granulation conditions are as follows: control the granulator air inlet temperature: 45-90°C; air outlet temperature: 40-85°C; material temperature: 60-80°C; drying time: 90-120 minutes, and discharge the material when the moisture content is ≤4.0%.