Traditional Chinese medicine composition for treating cerebral hemorrhage and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating cerebral hemorrhage and a preparation method thereof. The invention provides a traditional Chinese medicine composition for treating cerebral hemorrhage. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 20-26 parts of cortex mori radicis, 18-22 parts of radix scrophulariae, 18-22 parts of rhizoma nardostachyos, 16-20 parts of rheum officinale, 15-19 parts of earthworm, 14-18 parts of polygala tenuifolia, 11-15 parts of raw dens draconis, 8-12 parts of nacre mother of pearl, 6-10 parts of concha haliotidis, 5-7 parts of rhizoma polygonati, 4-6 parts of codonopsis pilosula and 4-6 parts of roasted rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition can stop bleeding, cool blood, calm liver wind, restore consciousness, induce resuscitation, reduce intracranial pressure and clean up intracranial hematoma under the synergistic effect of the traditional Chinese medicine composition, so that the technical effect of treating cerebral hemorrhage is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating cerebral hemorrhage and a preparation method thereof. Background Art

[0002] Cerebral hemorrhage, commonly known as cerebral hemorrhage, is a type of "cerebral stroke" and is a common disease in the middle-aged and elderly. Cerebral hemorrhage refers to bleeding caused by non-traumatic rupture of blood vessels in the brain parenchyma. The most common causes are hypertension, intracranial vascular malformations, cerebral arteriosclerosis, etc. It is often induced by factors such as exertion and emotional excitement, so most of them occur suddenly during activities. Clinically, cerebral hemorrhage develops very rapidly, and is mainly manifested as impaired consciousness, hemiplegia of limbs, aphasia and other damage to the nervous system. It has an acute onset, a dangerous condition, and a very high mortality rate. It is currently one of the fatal diseases in the middle-aged and elderly.

[0003] The treatment of cerebral hemorrhage is divided into two types: Western medicine and Chinese medicine. Western medicine has the advantages of rapid onset and strong targeted treatment. It is mostly used for acute treatment, but its disadvantages are single target and large side effects. Chinese medicine treatment for cerebral hemorrhage belongs to the category of "stroke" in Chinese medicine theory, which was first seen in "Golden Chamber Synopsis". Stroke is related to weak vital energy and invasion of external evil. Qi deficiency is unable to consolidate and promote blood; Qi failure to consolidate blood leads to blood not flowing through the meridians and blood overflowing outside the veins. In addition, the invasion of wind evil disturbs the mind and causes falls and fainting. As the course of the disease lasts for a long time, the blood out of the meridians turns into blood stasis and generates heat. The treatment is to harmonize qi and blood, and activate blood circulation and remove blood stasis. Chinese medicine treatment has the therapeutic effect of treating both the symptoms and the root causes. Although the therapeutic effect is good, its treatment cycle is long and the effect is slow in a short period of time, which is not suitable for patients in the acute stage.

[0004] Therefore, there is an urgent need for a Chinese medicine formula that is effective in treating cerebral hemorrhage to solve the technical problems of slow onset and poor therapeutic effect of the existing Chinese medicine for treating cerebral hemorrhage. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for treating cerebral hemorrhage and a preparation method thereof.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The invention provides a traditional Chinese medicine composition for treating cerebral hemorrhage. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 20-26 parts of mulberry bark, 18-22 parts of scrophulariae, 18-22 parts of nardostachys grandiflora, 16-20 parts of rhubarb, 15-19 parts of earthworms, 14-18 parts of polygala tenuifolia, 11-15 parts of raw dragon teeth, 8-12 parts of mother-of-pearl, 6-10 parts of selengensis cassia, 5-7 parts of polygonatum, 4-6 parts of codonopsis pilosula, and 4-6 parts of stir-fried atractylodes macrocephala.

[0008] The present invention also provides a method for preparing the Chinese medicine composition for treating cerebral hemorrhage, comprising the following steps:

[0009] (1) Mixing mulberry bark, Scrophularia ningpoensis, Nardostachys grandiflora, rhubarb, earthworm, Polygala tenuifolia, raw dragon tooth, mother-of-pearl, Semen Cassiae, Polygonatum sibiricum, Codonopsis pilosula, and stir-fried Atractylodes macrocephala to obtain material 1;

[0010] (2) mixing the material 1 with water and boiling, repeating the process 2 to 3 times, and combining the boiling solutions to obtain an extract;

[0011] (3) After the extract is concentrated under reduced pressure, an ethanol solution is added to the obtained extract until the volume concentration of ethanol in the extract is 62-66%, and the ethanol is filtered and recovered after standing. The obtained concentrated solution is dried and crushed to obtain a traditional Chinese medicine composition for treating cerebral hemorrhage.

[0012] Preferably, the mass ratio of the material 1 to water in step (2) is 1:4-8.

[0013] Preferably, the decocting time in step (2) is 60 to 120 minutes.

[0014] Preferably, the extract in step (3) is concentrated under reduced pressure to an extract having a relative density of 1.12 to 1.18 at 60°C.

[0015] Preferably, the standing time in step (3) is 11 to 16 hours.

[0016] Preferably, the ambient temperature during the standing still in step (3) is set to 2-6°C.

[0017] Preferably, the drying temperature in step (3) is 70-90°C.

[0018] Preferably, the drying time in step (3) is 2 to 4 hours.

[0019] Preferably, the pulverized material in step (3) is passed through a 100-180 mesh sieve, and the material below the sieve is the traditional Chinese medicine composition for treating cerebral hemorrhage.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] The Chinese medicine prescription for treating cerebral hemorrhage provided by the present invention mainly cools blood and removes blood stasis, detoxifies, and calms the liver and suppresses yang, and replenishes vital energy. Among the added Chinese medicine components, Morus alba has the effect of clearing heat and cooling blood, Nardostachys grandiflora has the effect of removing blood stasis, Scrophularia ningpoensis clears heat and cools blood, nourishes yin and reduces fire, and relieves toxicity and disperses knots. Rhubarb has the effects of purging accumulation, clearing heat and purging fire, cooling blood and detoxifying, and removing blood stasis and dredges the menstruation. Pheretima has the effects of clearing heat and detoxifying, clearing heat and calming convulsions, and unblocking meridians, Polygala tenuifolia dredges qi and blood, Raw dragon teeth calms the latent yang, Pearl mother calms the liver and suppresses yang, calms the nerves and calms convulsions, improves eyesight and removes cataracts, Semen Cassiae has the effects of calming the liver and suppressing yang, clearing the liver and improving eyesight, Polygonatum sibiricum replenishes qi and nourishes yin, strengthens the spleen, moistens the lungs, and benefits the kidneys, Codonopsis pilosula replenishes the middle qi and replenishes qi, promotes fluid and nourishes blood, and stir-fried Atractylodes macrocephala has the effects of drying dampness and promoting water circulation, and replenishing qi. The Chinese medicine combination of the present invention has a synergistic effect on each other, can stop bleeding and cool blood, calm the liver and extinguish wind, wake up the brain and open the mind, reduce intracranial pressure, and cleanse intracerebral hematoma, thereby achieving the technical effect of effectively treating cerebral hemorrhage. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0023] Figure 1 This is a statistical chart of the neurobehavioral scores of rats in Experimental Example 1.

[0024] Figure 2 This is a statistical chart of the average awakening time of rats in Experimental Example 1. DETAILED DESCRIPTION

[0025] The invention provides a traditional Chinese medicine composition for treating cerebral hemorrhage, which is prepared from the following components by weight: 20-26 parts of white mulberry bark, 18-22 parts of Scrophularia ningpoensis, 18-22 parts of Nardostachys grandiflora, 16-20 parts of Rhubarb, 15-19 parts of Pheretima wormwood, 14-18 parts of Polygala tenuifolia, 11-15 parts of Raw Dragon Tooth, 8-12 parts of Mother of Pearl, 6-10 parts of Semen Cassiae, 5-7 parts of Polygonatum sibiricum, 4-6 parts of Codonopsis pilosula, and 4-6 parts of stir-fried Atractylodes macrocephala; preferably 21-25 parts of white mulberry bark, 19-21 parts of Scrophularia ningpoensis, 19-21 parts of Nardostachys grandiflora, 17-19 parts of Rhubarb, 16-18 parts of Pheretima wormwood, 15-17 parts of Polygala tenuifolia, and Raw Dragon Tooth. 12-14 parts of dragon teeth, 9-11 parts of mother-of-pearl, 7-9 parts of stone cassia, 6 parts of polygonatum, 6 parts of codonopsis, and 6 parts of stir-fried atractylodes; more preferably 22-24 parts of mulberry bark, 20 parts of scrophulariae, 20 parts of sweet osmanthus, 18 parts of rhubarb, 17 parts of earthworms, 16 parts of polygala, 13 parts of raw dragon teeth, 10 parts of mother-of-pearl, 8 parts of stone cassia, 6 parts of polygonatum, 6 parts of codonopsis, and 6 parts of stir-fried atractylodes; more preferably 23 parts of mulberry bark, 20 parts of scrophulariae, 20 parts of sweet osmanthus, 18 parts of rhubarb, 17 parts of earthworms, 16 parts of polygala, 13 parts of raw dragon teeth, 10 parts of mother-of-pearl, 8 parts of stone cassia, 6 parts of polygonatum, 6 parts of codonopsis, and 6 parts of stir-fried atractylodes.

[0026] The present invention also provides a method for preparing the Chinese medicine composition for treating cerebral hemorrhage, comprising the following steps:

[0027] (1) Mixing mulberry bark, Scrophularia ningpoensis, Nardostachys grandiflora, rhubarb, earthworm, Polygala tenuifolia, raw dragon tooth, mother-of-pearl, Semen Cassiae, Polygonatum sibiricum, Codonopsis pilosula, and stir-fried Atractylodes macrocephala to obtain material 1;

[0028] (2) mixing the material 1 with water and boiling, repeating the process 2 to 3 times, and combining the boiling solutions to obtain an extract;

[0029] (3) After the extract is concentrated under reduced pressure, an ethanol solution is added to the obtained extract until the volume concentration of ethanol in the extract is 62-66%, and the ethanol is filtered and recovered after standing. The obtained concentrated solution is dried and crushed to obtain a traditional Chinese medicine composition for treating cerebral hemorrhage;

[0030] In the present invention, the number of times of decocting in step (2) is preferably 3 times.

[0031] In the present invention, in step (3), the ethanol solution is added to the obtained extract until the volume concentration of ethanol in the extract is preferably 63-65%, and more preferably 64%.

[0032] In the present invention, the mass ratio of the material 1 to water in step (2) is 1:4-8; preferably 1:5-7; and more preferably 1:6.

[0033] In the present invention, the decocting time in step (2) is 60 to 120 min, preferably 70 to 110 min, more preferably 80 to 100 min, and more preferably 90 min.

[0034] In the present invention, the extract in step (3) is concentrated under reduced pressure to an extract having a relative density at 60° C. of 1.12 to 1.18; preferably 1.13 to 1.17; more preferably 1.14 to 1.16; and more preferably 1.15.

[0035] In the present invention, the standing time in step (3) is 11 to 16 hours, preferably 12 to 15 hours, more preferably 13 to 14 hours, and more preferably 14 hours.

[0036] In the present invention, the ambient temperature during the standing in step (3) is set to 2-6°C; preferably 3-5°C; more preferably 4°C.

[0037] In the present invention, the drying temperature in step (3) is 70-90°C, preferably 74-86°C, more preferably 78-82°C, and more preferably 80°C.

[0038] In the present invention, the drying time in step (3) is 2 to 4 hours, preferably 3 hours.

[0039] In the present invention, the pulverized material in step (3) is sieved through a 100-180 mesh sieve, and the material under the sieve is the traditional Chinese medicine composition for treating cerebral hemorrhage; preferably 110-170 mesh; more preferably 120-160 mesh; and more preferably 140 mesh.

[0040] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0041] Example 1

[0042] A method for preparing a Chinese medicine composition for treating cerebral hemorrhage, comprising the following steps:

[0043] (1) Mix 20 parts of Morus alba bark, 18 parts of Scrophularia ningpoensis, 18 parts of Nardostachys grandiflora, 16 parts of Rhubarb, 15 parts of Pheretima, 14 parts of Polygala tenuifolia, 11 parts of Dragon's Tooth, 8 parts of Mother of Pearl, 6 parts of Semen Cassiae, 5 parts of Polygonatum sibiricum, 4 parts of Codonopsis pilosula, and 4 parts of stir-fried Atractylodes macrocephala to obtain material 1;

[0044] (2) mixing the material 1 with water in a mass ratio of 1:4 and boiling for 60 min, repeating twice, and combining the decoctions to obtain an extract;

[0045] (3) The extract is concentrated under reduced pressure to an extract having a relative density of 1.12 at 60° C., an ethanol solution is added to the obtained extract until the volume concentration of ethanol in the extract is 62%, and the extract is allowed to stand at 2° C. for 11 h, then filtered and ethanol is recovered. The obtained concentrated solution is dried at 70° C. for 2 h, crushed, and passed through a 100-mesh sieve. The sieved material is the traditional Chinese medicine composition for treating cerebral hemorrhage.

[0046] Example 2

[0047] A method for preparing a Chinese medicine composition for treating cerebral hemorrhage, comprising the following steps:

[0048] (1) Mix 26 parts of Morus alba bark, 22 parts of Scrophularia ningpoensis, 22 parts of Nardostachys grandiflora, 20 parts of Rhubarb, 19 parts of Pheretima, 18 parts of Polygala tenuifolia, 15 parts of Dragon's Teeth, 12 parts of Mother of Pearl, 10 parts of Semen Cassiae, 7 parts of Polygonatum sibiricum, 6 parts of Codonopsis pilosula, and 6 parts of Rhizoma Atractylodis Macrocephalae to obtain Material 1;

[0049] (2) mixing the material 1 with water in a mass ratio of 1:8 and boiling for 120 min, repeating 3 times, and combining the decoctions to obtain an extract;

[0050] (3) The extract is concentrated under reduced pressure to an extract having a relative density of 1.18 at 60° C., and an ethanol solution is added to the obtained extract until the volume concentration of ethanol in the extract is 66%. The extract is allowed to stand at 6° C. for 16 h, then filtered and the ethanol is recovered. The obtained concentrated solution is dried at 90° C. for 4 h, crushed, and passed through a 180-mesh sieve. The sieved material is the traditional Chinese medicine composition for treating cerebral hemorrhage.

[0051] Example 3

[0052] A method for preparing a Chinese medicine composition for treating cerebral hemorrhage, comprising the following steps:

[0053] (1) Mix 23 parts of Morus alba bark, 20 parts of Scrophularia ningpoensis, 20 parts of Nardostachys grandiflora, 18 parts of Rheum officinale, 17 parts of Pheretima, 16 parts of Polygala tenuifolia, 13 parts of Dragon's Teeth, 10 parts of Mother of Pearl, 8 parts of Semen Cassiae, 6 parts of Polygonatum sibiricum, 6 parts of Codonopsis pilosula, and 6 parts of stir-fried Atractylodes macrocephala to obtain material 1;

[0054] (2) mixing the material 1 with water in a mass ratio of 1:6 and boiling for 90 minutes, repeating 3 times, and combining the decoctions to obtain an extract;

[0055] (3) The extract is concentrated under reduced pressure to an extract having a relative density of 1.15 at 60° C., and an ethanol solution is added to the obtained extract until the volume concentration of ethanol in the extract is 64%. The extract is allowed to stand at 4° C. for 14 h, and then filtered to recover the ethanol. The obtained concentrated solution is dried at 80° C. for 3 h, crushed, and passed through a 100-180 mesh sieve. The material under the sieve is the traditional Chinese medicine composition for treating cerebral hemorrhage.

[0056] Experimental Example 1

[0057] Forty 8-week-old male SD rats with a body weight range of 180±20g were randomly divided into sham operation group, model group, experimental group and control group.

[0058] Among them, the product obtained in Example 3 was used as the experimental group;

[0059] Control group: The only difference from Example 3 is that Morus alba bark is replaced by an equal amount of Paeonia lactiflora, Scrophularia ningpoensis is replaced by an equal amount of Rehmannia glutinosa, and Nardostachys grandiflora is replaced by an equal amount of Panax notoginseng.

[0060] Modeling: Rats were fasted for 12 hours before surgery and anesthetized by intraperitoneal injection of 100 mg / L chloral hydrate solution (300 mg / kg body weight). After the rats were fixed, the hair on the back of the head was shaved and disinfected. Then a longitudinal incision of about 1.5 cm was made. The skull aponeurosis and pericranium were corroded with 30% hydrogen peroxide solution to expose the anterior fontanelle. A 50 mL syringe needle was used to drill a 1.0 mm round hole 1 mm behind the anterior fontanelle and 3 mm to the left of the midline. The dura mater was not damaged. A micro-syringe was used to vertically insert the needle along the drilling direction to a depth of 6.0 mm. Then, 2 μL (0.25 U / μL) of type VII collagenase was slowly and evenly pushed into the brain with a micro-syringe pump at a constant speed (0.2 μL / min). The needle was left in place for 10 minutes and the skin incision was sutured. In the sham operation group, except for the injection of normal saline with a micro-syringe pump, the rest of the operations were consistent with the model making.

[0061] In addition to the model group and the sham operation group, which were gavaged with normal saline every day, the experimental group and the control group were given the corresponding drugs (35 mg / kg body weight) every day, which were dissolved in water and then gavaged. Rectal temperature was measured 1 hour after administration, and orbital blood was collected. After blood collection, penicillin was injected intramuscularly at 0.1 mL / head, and the blood was centrifuged at 3500 r / min for 10 minutes, and the supernatant was taken for measurement. The corresponding indicators were measured on the 1st, 3rd, 5th, and 7th days.

[0062] The scoring was performed according to the Longa scoring method (Liu L, Wang D, Wong KS, et al. Stroke and stroke care in China: huge burden, significant workload, and a national priority [J]. Shock, 2011, 42(12): 3651.).

[0063] Lift the tail of the rat and observe its behavior. Normal rats straighten their front paws. 0 points: no neurological deficit; 1 point: the right front paw cannot be fully extended; 2 points: when walking, the rat turns to the left; 3 points: when walking, the rat's body falls to the left (healthy side); 4 points: unable to walk spontaneously and lose consciousness. 1 to 3 points indicate successful modeling. Neurobehavioral scores were performed before surgery, 6 hours after surgery, and 1 hour after drug administration on the 1st, 3rd, 5th, and 7th days.

[0064] Each group of rats was injected with anesthetics according to their body weight, and the anesthesia time was accurately recorded during anesthesia. After the operation, the awakening time of each group of animals was observed.

[0065] Rectal temperature was measured before the first experiment and then 1 hour after drug administration and before orbital blood sampling every day.

[0066] Serum specific enolase NSE was determined according to the ELISA kit instructions. The results were averaged, as shown in Tables 1 to 4.

[0067] Table 1 Neurobehavioral scores

[0068] Group 6h 1d 3d 5d 7d Sham operation group 0.32 0.21 0.67 0.82 1.29 Model Group 2.56 2.24 3.21 3.37 3.05 Experimental Group 2.51 1.96 1.62 1.38 0.82 Control group 2.35 2.16 2.11 1.89 1.67

[0069] As shown in Table 1, the neurobehavioral scores of the experimental group and the control group were significantly lower than those of the model group, indicating that the composition provided by the present invention has a significant improvement effect on the neurobehavioral scores of rats. The neurobehavioral scores of rats in the sham operation group increased every day, which may be due to the impact of modeling on the brain.

[0070] Table 2 Average awakening time

[0071] Group t / h Sham operation group 1.6 Model Group 3.1 Experimental Group 1.9 Control group 2.5

[0072] From the contents recorded in Table 2, it can be seen that the average awakening time of rats in the experimental group is significantly shorter than that in the model group. Although the average awakening time of rats in the control group is significantly shorter than that in the model group, it is also significantly longer than that in the experimental group.

[0073] Table 3 Rectal temperature (℃)

[0074] Group Before modeling 6h 1d 3d 5d 7d Sham operation group 36.9 38.2 37.8 37.9 37.5 37.7 Model Group 37.1 38.1 37.8 37.6 37.5 37.1 Experimental Group 37.4 38.1 37.4 37.0 36.8 36.5 Control group 37.2 37.9 37.5 37.2 37.0 36.9

[0075] From the contents recorded in Table 3, it can be seen that the rectal temperature of the experimental group was significantly lower than that of the other three groups, and the rectal temperature of the control group was significantly higher than that of the experimental group.

[0076] Table 4 NSE [ρ / (μg·mL -1 )]

[0077] Group 6h 1d 3d 5d 7d Sham operation group 0.462 0.421 0.355 0.459 0.517 Model Group 0.867 0.660 0.684 0.615 0.598 Experimental Group 0.632 0.587 0.551 0.536 0.529 Control group 0.655 0.624 0.618 0.572 0.560

[0078] The preparations used in the experimental group could reduce the serum NSE level of rats to varying degrees, and the data were significantly lower than those in the model group.

[0079] It is not difficult to see from the data in Tables 1 to 4 that the Chinese medicine composition provided by the present invention has a significant improvement effect on the neurological function score of rats with acute cerebral hemorrhage, can accelerate the awakening time of rats with cerebral hemorrhage, reduce the anal temperature of rats with cerebral hemorrhage, and reduce the serum NSE level of rats with cerebral hemorrhage, indicating that the prescription has the technical effects of cooling blood, removing blood stasis, detoxifying, and awakening the brain.

[0080] Experimental Example 2

[0081] Patient selection: The present invention selected 60 clinical hospitalized cases of cerebral hemorrhage diagnosed by head CT or MRI examination, including 30 males and 30 females with an average age of 48.3 years old, and divided them into three groups, with half males and half females in each group.

[0082] Diagnostic criteria: Traditional Chinese medicine diagnostic criteria: refer to "Traditional Chinese Medicine Diagnosis and Efficacy Standards for Stroke (Trial)".

[0083] Western medicine diagnostic standards: refer to the "Key Points for Diagnosis of Various Cerebrovascular Diseases" and confirm the diagnosis through CT or MRI examination.

[0084] Inclusion criteria: Patients meet the diagnostic criteria for hypertensive cerebral hemorrhage, CT scan shows hematoma of more than 30 ml, onset within 96 hours, relatively stable vital signs, and consciousness level below level IV; family consent.

[0085] Exclusion criteria: coagulation disorder, brain hemorrhage caused by brain tumors and other factors, accompanied by severe damage to important organs such as the heart, liver and kidneys.

[0086] Treatment:

[0087] The experimental group and the control group were the same as those in Experimental Example 1; the specific dosage was 20 g / d, taken with warm water.

[0088] Prior art group: took Oxiracetam capsules and followed the dosage prescribed by the doctor.

[0089] Patients take the medication for 30 days as a course of treatment, and take it for 3 consecutive courses. After completing the treatment, the head CT scan is repeated and the degree of improvement in neurological function damage is scored to observe the hematoma absorption and evaluate the efficacy.

[0090] Efficacy evaluation criteria:

[0091] Cured: Hemiplegic limbs recovered to level 5, consciousness is normal, there is no difficulty in language expression, and the patient can take care of himself.

[0092] Markedly effective: Language expression is not yet completely fluent, muscle strength has recovered to level 3-4, and the patient can take care of himself or semi-independently.

[0093] Effective: Vital signs are normal; hemiplegic limbs improve, muscle strength recovers to level 2-3, language expression is not fluent, and the patient cannot take care of himself.

[0094] Ineffective: died from complications, clinical death.

[0095] The treatment results are shown in Table 5.

[0096] Table 5 Treatment results

[0097] Group cure Significant effect efficient invalid Existing Technology Group 14 3 1 2 Experimental Group 13 4 2 1 Control group 9 4 3 4

[0098] As can be seen from Table 5, the therapeutic effect of the experimental group is comparable to that of the drugs in the prior art, while the therapeutic effect of the control group is significantly reduced, which indicates that the replacement of the drug components affects the efficacy of the composition.

[0099] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating cerebral hemorrhage, characterized in that: The invention is prepared from the following components in parts by weight: 20-26 parts of mulberry bark, 18-22 parts of scrophulariae, 18-22 parts of nard, 16-20 parts of rhubarb, 15-19 parts of earthworms, 14-18 parts of polygala, 11-15 parts of raw dragon teeth, 8-12 parts of mother-of-pearl, 6-10 parts of cassia bark, 5-7 parts of polygonatum, 4-6 parts of codonopsis, and 4-6 parts of stir-fried atractylodes.

2. The method for preparing a Chinese medicine composition for treating cerebral hemorrhage according to claim 1, characterized in that: The steps include: (1) Mixing mulberry bark, Scrophularia ningpoensis, Nardostachys grandiflora, rhubarb, earthworm, Polygala tenuifolia, raw dragon tooth, mother-of-pearl, Semen Cassiae, Polygonatum sibiricum, Codonopsis pilosula, and stir-fried Atractylodes macrocephala to obtain material 1; (2) mixing the material 1 with water and boiling, repeating the process 2 to 3 times, and combining the boiling solutions to obtain an extract; (3) After the extract is concentrated under reduced pressure, an ethanol solution is added to the obtained extract until the volume concentration of ethanol in the extract is 62-66%, and the ethanol is filtered and recovered after standing. The obtained concentrated solution is dried and crushed to obtain a traditional Chinese medicine composition for treating cerebral hemorrhage.

3. The method for preparing a Chinese medicine composition for treating cerebral hemorrhage according to claim 2, characterized in that: The mass ratio of the material 1 to water in step (2) is 1:4-8.

4. The method for preparing a Chinese medicine composition for treating cerebral hemorrhage according to claim 2, characterized in that: The decocting time in step (2) is 60 to 120 minutes.

5. The method for preparing a Chinese medicine composition for treating cerebral hemorrhage according to claim 2, characterized in that: The extract in step (3) is concentrated under reduced pressure to an extract having a relative density of 1.12 to 1.18 at 60°C.

6. The method for preparing a Chinese medicine composition for treating cerebral hemorrhage according to claim 2, characterized in that: The standing time in step (3) is 11 to 16 hours.

7. A method for preparing a Chinese medicine composition for treating cerebral hemorrhage according to claim 2 or 6, characterized in that: The ambient temperature during the standing state in step (3) is set to 2-6°C.

8. The method for preparing a Chinese medicine composition for treating cerebral hemorrhage according to claim 2, characterized in that: The drying temperature in step (3) is 70-90°C.

9. A method for preparing a Chinese medicine composition for treating cerebral hemorrhage according to claim 2 or 8, characterized in that: The drying time in step (3) is 2 to 4 hours.

10. The method for preparing a Chinese medicine composition for treating cerebral hemorrhage according to claim 2, characterized in that: The crushed material in step (3) is passed through a 100-180 mesh sieve, and the material below the sieve is the traditional Chinese medicine composition for treating cerebral hemorrhage.

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