Traditional Chinese medicine composition for treating arthralgia and preparation and application thereof

Through a traditional Chinese medicine preparation made of a traditional Chinese medicine composition containing medicinal materials such as Duhuo and Mulberry Parasitism, the problem of poor effectiveness in treating lumbar disc herniation with radiculopathy and knee osteoarthritis is solved, and the effect of significantly improving symptoms and reducing recurrence rate is achieved.

CN119970971APending Publication Date: 2025-05-13长治医学院附属和济医院
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Patent Information

Application Number
CN202510182176.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2024-05-22
Filing Date
2025-02-19
Publication Date
2025-05-13

AI Technical Summary

Technical Problem

The prior art is ineffective in treating lumbar disc herniation with radiculopathy and knee osteoarthritis, and long-term use of Western medicine is prone to drug resistance and side effects.

Method used

A Chinese medicine composition is proposed, including medicinal materials such as Duhuo, Mulberry Parasitology, Tengjincao, Bone-Turning Grass, Chicken Blood Vine, Lulutong, Mugwort, Dried Ginger, Dog Ridge and Astragalus, and is prepared into a Chinese medicine preparation through decoction and is used to treat the above-mentioned numb disease.

Benefits of technology

Significantly improves the symptoms of numb disease, effectively relieves pain, restores joint activity, reduces the recurrence rate of disease, and has no side effects, and has long-term effects and sustainability.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention provides a traditional Chinese medicine composition for treating arthralgia and a preparation and application thereof. The traditional Chinese medicine composition for treating arthralgia is prepared from the following raw materials in parts by weight: 12 to 18 parts of radix angelicae pubescentis, 12 to 18 parts of herba taxilli, 12 to 18 parts of herba lycopodii, 12 to 18 parts of herba speranskiae tuberculatae, 12 to 18 parts of caulis spatholobi, 12 to 18 parts of fructus liquidambaris, 15 to 25 parts of folium artemisiae argyi, 8 to 12 parts of rhizoma zingiberis, 12 to 18 parts of rhizoma cibotii and 12 to 18 parts of radix astragali seu hedysari. The traditional Chinese medicine formula disclosed by the invention is used for treating arthralgia diseases such as lumbar disc herniation with nerve root disease and knee osteoarthritis, effectively regulating qi and blood, promoting blood circulation to remove blood stasis, warming and dredging meridians and collaterals and the like, remarkably improving the symptoms of the arthralgia diseases, and not only can effectively relieve pain, but also can recover the joint movement function and reduce the disease recurrence rate. Meanwhile, the traditional Chinese medicine treatment can adjust the overall balance of the human body, improve the disease resistance of the body and promote rehabilitation; the health of the patient is guaranteed, and meanwhile, the long-term effect and sustainability are achieved.
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Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating arthralgia, and a preparation and application thereof. Background Art

[0002] Bi disease refers to a disease caused by insufficient vital energy, invasion of external pathogens such as wind, cold, dampness, and heat, which blocks the meridians and causes poor circulation of qi and blood. The main clinical manifestations are pain, numbness, heaviness, difficulty in flexion and extension, and even swelling and burning of joints in muscles, tendons, bones, and joints. Bi diseases include lumbar disc herniation with radiculopathy, knee osteoarthritis, scapulohumeral periarthritis, rheumatoid arthritis, ankylosing spondylitis, cervical spondylosis, etc.

[0003] The main problems of arthralgia include severe pain, limited mobility, poor quality of life, and easy relapse. Modern medicine mostly uses Western medicine for treatment, such as analgesics, anti-inflammatory drugs, hormones, etc., but long-term use of drugs is prone to drug resistance and side effects. Currently, traditional Chinese medicine for the treatment of lumbar disc herniation with radiculopathy and knee osteoarthritis is not effective. Summary of the invention

[0004] In view of this, the present invention provides a Chinese medicine composition for treating arthralgia and its preparation and application.

[0005] The technical scheme of the present invention is achieved as follows: a traditional Chinese medicine composition for treating arthritis is prepared by comprising the following raw materials in parts by weight: 12-18 parts of Angelica dahurica, 12-18 parts of Morus alba, 12-18 parts of Herba Lycopodii, 12-18 parts of Herba Polygoni Multiflori, 12-18 parts of Herba Spatholobi, 12-18 parts of Folium Spatholobi, 12-18 parts of Folium Lycopodii, 15-25 parts of Folium Artemisiae Argyi, 8-12 parts of Dried Ginger, 12-18 parts of Cibotium Cibotium, and 12-18 parts of Radix Astragali.

[0006] Furthermore, the Chinese medicine composition for treating arthritis is made from the following raw materials in parts by weight: 15 parts of Angelica dahurica, 15 parts of Viscum album, 15 parts of Herba Lycopodii, 15 parts of Herba Polygoni Multiflori, 15 parts of Millettia reticulatae, 15 parts of Fructus Smilacis Glabrae, 20 parts of Artemisia argyi, 10 parts of dried ginger, 15 parts of Cibotium barometz, and 15 parts of Astragalus.

[0007] Furthermore, the Chinese medicine composition for treating arthritis also includes the following raw materials: Chuanxiong, Clematis, Atractylodes, Cassia twig, and Saposhnikovia divaricata. In parts by weight, the Chinese medicine composition is composed of the following raw materials: 12-18 parts of Angelica dahurica, 12-18 parts of Viscum album, 12-18 parts of Lycopodiella ciliata, 12-18 parts of Spatholobus spatholobi, 12-18 parts of Fructus Spatholobi, 12-18 parts of Rhizoma Spatholobi, 15-25 parts of Artemisia argyi, 8-12 parts of dried ginger, 12-18 parts of Cibotium barometz, 12-18 parts of Astragalus, 8-12 parts of Chuanxiong, 8-12 parts of Clematis, 8-12 parts of Atractylodes, 8-12 parts of Cassia twig, and 4-6 parts of Saposhnikovia divaricata.

[0008] Furthermore, the Chinese medicine composition for treating arthritis is prepared from the following raw materials in parts by weight: 15 parts of Angelica dahurica, 15 parts of Viscum album, 15 parts of Herba Lycopodii, 15 parts of Herba Polygoni Multiflori, 15 parts of Millettia reticulatae, 15 parts of Fructus Smilacis Glabrae, 20 parts of Artemisia argyi, 10 parts of dried ginger, 15 parts of Cibotium barometz, 15 parts of Astragalus, 10 parts of Rhizoma Chuanxiong, 10 parts of Radix Clematis, 10 parts of Atractylodes macrocephalae, 10 parts of Cassia twig, and 6 parts of Saposhnikovia divaricatae.

[0009] A traditional Chinese medicine preparation for treating arthralgia is prepared according to any one of the traditional Chinese medicine compositions of the present invention.

[0010] Furthermore, the Chinese medicine preparation for treating arthritis is prepared by soaking each medicinal material for 1.5-2.5 hours, adding 2500-3500 ml of water for decoction, boiling over high heat, then turning to low heat, and continuing to decoct for 0.4-0.6 hours. Pour out the residue, and let the water reach 39-42° C. for later use.

[0011] The Chinese medicine composition described in any one of the items of the present invention is used in the preparation of medicines for treating arthritis, including lumbar disc herniation with radiculopathy, knee osteoarthritis, scapulohumeral periarthritis, rheumatoid arthritis, ankylosing spondylitis, and cervical spondylosis.

[0012] Compared with the prior art, the present invention has the following beneficial effects:

[0013] In this prescription, Angelica dahurica, Viscum album and Astragalus membranaceus are the main ingredients. Angelica dahurica has the effects of dispelling wind and dampness, relieving numbness and relieving pain; Viscum album dispels rheumatism, nourishes the liver and kidneys, and strengthens the tendons and bones; Astragalus membranaceus can nourish Qi and raise Yang, consolidate the exterior and stop sweating, promote diuresis and reduce swelling, and relieve stagnation and numbness. Together, the three ingredients can nourish the liver and kidneys, dispel wind and dredge the meridians, and remove dampness and relieve pain. The herb has the functions of dispelling wind and dampness, relaxing muscles and tendons, and unblocking meridians; the herb can dispel wind and dampness, unblock meridians, and relieve pain. At the same time, it can detoxify and dissipate rashes when used externally to prevent skin allergies; Millettia reticulata can invigorate blood circulation, replenish blood, relax muscles and tendons, and relieve pain; Rhizoma Lulutong can dispel wind and unblock meridians, promote diuresis and reduce swelling, and can also relieve itching when used together with Rhizoma Lulutong; Rhizoma Lulutong can dispel wind and activate meridians, promote diuresis and remove dampness, and can work together with Rhizoma Lulutong and Astragalus to promote diuresis and reduce swelling, and can eliminate limb swelling; Artemisia argyi warms the meridians, dispels cold and relieves pain, removes dampness and relieves itching, and can work together with Rhizoma Lulutong and Rhizoma Lulutong to prevent skin itching that may be caused by external use, etc. The above medicines are the assistant medicines, and they work together to dispel wind and dredge collaterals, promote blood circulation and qi, dispel dampness and relieve itching. The white atractylodes macrocephala is used to invigorate the spleen, dry dampness and promote diuresis, and is used together with the astragalus to invigorate qi and promote diuresis. The cinnamon twig is pungent and warm, and has the functions of warming the meridians and dredge the channels, assisting yang and transforming qi. The dried ginger is used as an adjuvant to dispel cold and dredge the channels. The three work together to warm yang and dredge the channels, and are particularly effective for the deficiency-cold syndrome. The windproof is used as the guiding medicine to dispel wind and resolve the exterior symptoms, overcome dampness and relieve pain, and can resolve the cold and dampness on the surface. The whole prescription works together to dispel rheumatism, dredge the meridians, relieve pain, invigorate qi and activate blood circulation, and nourish the liver and kidney. It is effective in treating arthritis caused by the combination of wind, cold and dampness, or liver and kidney deficiency and insufficient qi and blood, such as lumbar disc herniation with radiculopathy and knee osteoarthritis.

[0014] (1) The Chinese medicine formula of the present invention is used to treat arthralgia such as lumbar disc herniation with radiculopathy and knee osteoarthritis, effectively regulates qi and blood, promotes blood circulation and removes blood stasis, warms and dredges the meridians, and significantly improves arthralgia symptoms, not only effectively relieves pain, but also restores joint activity function and reduces the recurrence rate of the disease. It has a definite curative effect, is safe and has no side effects. At the same time, Chinese medicine treatment can also adjust the overall balance of the human body, improve the body's ability to resist lesions, and promote recovery; while ensuring the health of patients, it also has a long-term effect and sustainability.

[0015] (2) The prescription of the present invention is more rigorous, has a definite therapeutic effect on various arthritis diseases such as lumbar disc herniation with radiculopathy, knee osteoarthritis, scapulohumeral periarthritis, rheumatoid arthritis, ankylosing spondylitis, cervical spondylosis, etc., and has a wide range of clinical applications.

[0016] (3) The drugs used in the present invention are inexpensive, and the economic burden on the majority of patients is small. DETAILED DESCRIPTION

[0017] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0018] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0019] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0020] 1. Angelica dahurica: It is the dried root of the Umbelliferae plant Angelica sinensis. It tastes spicy and bitter, and is slightly warm. Its main chemical components are coumarins and volatile oils. It has the effects of removing dampness and relieving pain. Modern pharmacological studies have found that Angelica dahurica can block the production of inflammatory factors such as IL-1 and IL-6 through signaling pathways such as TNF and NF-κB; and bind to key targets such as IL-6 and VEGFA, and reduce the levels of VEGFA in a concentration-dependent manner to exert anti-inflammatory effects. In addition, Angelica dahurica can also increase the activity of SOD in serum to resist oxidation; reduce blood viscosity, increase blood flow velocity, etc. to improve blood circulation; relieve pain and protect neurons.

[0021] 2. Mulberry parasite: It is the dried leafy stems and branches of the plant Mulberry parasite of the family Loranthaceae. It is mild in nature, sweet and bitter in taste, and can nourish the liver and kidneys, strengthen the tendons and bones, dispel wind and dampness, dredge the meridians, benefit the blood, and stabilize the fetus. The main chemical components are flavonoids, terpenes, and sterols, which have the effects of inhibiting inflammatory response, antioxidant activity, enhancing immunity, and resisting osteoporosis. Studies have found that Mulberry parasite can reduce the secretion of proinflammatory factors IL-1β and IL-6, PGE2, iNOS, and COX-2 through multiple signaling pathways such as NF-κB, thereby alleviating inflammatory hyperplasia and bone and joint damage.

[0022] 3. Stretch grass: It has anti-inflammatory and analgesic effects, regulates immunity, treats rheumatoid arthritis, prevents experimental silicosis, affects the central nervous system drug effects and inhibits acetylcholinesterase activity. Clinically, it has a definite effect on radiculopathy, tendon spasm, joint flexion, acute and chronic soft tissue injury, rheumatoid joint swelling and pain, gout, etc., with few adverse reactions and low price.

[0023] 4. Chuanxiong: It can promote blood circulation and qi, dispel wind and relieve pain, and can calm the nerves, relieve pain and improve microcirculation.

[0024] 5. Clematis: It has the functions of eliminating rheumatism, unblocking meridians, relieving pain, and is anti-bacterial, anti-inflammatory and analgesic.

[0025] 6. Cinnamon twig: It can induce sweating, relieve muscle tension, warm and unclog the meridians. It has antibacterial, anti-inflammatory, sedative, analgesic effects and improves blood circulation.

[0026] 7. Radix Polygoni Multiflori: It has the functions of promoting blood circulation, removing blood stasis, relaxing muscles and tendons, and has anti-bacterial, anti-inflammatory and analgesic effects.

[0027] 8. Millettia reticulata: Its main effects are promoting blood circulation and replenishing blood, regulating menstruation and relieving pain, relaxing muscles and activating collaterals; its target symptoms are numbness of hands and feet, blood stasis and pain, and irregular menstruation; its target is low blood cells and hemoglobin; modern pharmacology has found that Millettia reticulata and its active ingredients have anti-tumor, treatment of diabetes and its complications, anti-inflammatory, analgesic, cardiovascular improvement, and antiviral effects.

[0028] 9. Lulutong: bitter in nature and flavor, flat, enters the liver and kidney meridians, has the effects of dispelling wind and activating collaterals, promoting diuresis and dredges the menstrual period. It is used for joint pain, numbness and cramps, edema and fullness. Modern pharmacological research shows that Lulutong has anti-inflammatory and analgesic effects, and is mainly used clinically for pain relief, diuresis, and lactation.

[0029] 10. Dried ginger: It has the effects of warming the middle and dispersing cold, restoring yang and unblocking meridians, warming the lungs and transforming phlegm. It is used to restore yang and unblock meridians to restore yang energy and unblock blood vessels.

[0030] 11. Cinnamon twig: Induces sweat and relieves muscle pain: It can be used for symptoms of wind-cold caused by external factors, and can make the wind-cold evil dissipate through sweating. Warming and unblocking meridians: It can warm the meridians and dispel cold, unblock blood vessels, and is often used for various pain symptoms caused by cold stagnation and blood stasis. Assisting yang and transforming qi: It can supplement yang qi, warm and transform water and dampness, and can be used for symptoms such as insufficient yang qi and internal water and dampness. It is used for its function of warming the meridians and unblocking the meridians.

[0031] 12. Astragalus, Atractylodes, and Saposhnikovia: tonify Qi and strengthen the exterior, enhance the body's external defense function, improve the body's resistance, and reduce symptoms such as spontaneous sweating.

[0032] 13. Cibotium barometz: It has the following effects and functions: Nourishing the liver and kidneys: It can strengthen the waist and knees, and has a certain improvement effect on the soreness of the waist and knees caused by liver and kidney deficiency; Strengthening the tendons and bones: It helps to enhance the strength and intensity of the tendons and bones; Eliminating rheumatism: It can relieve symptoms such as rheumatic arthralgia.

[0033] 14. Mugwort: The main effects and functions include: warming the meridians and stopping bleeding: it can be used for cold-induced bleeding; dispelling cold and relieving pain: it can relieve menstrual pain caused by cold and dampness, and arthralgia caused by cold and dampness; removing dampness and relieving itching: it can remove dampness and relieve itching when used externally. Modern pharmacological studies have shown that mugwort has antibacterial and antiviral effects. It has certain antiasthmatic, antitussive and expectorant effects. It has a certain regulatory effect on immune function. It also has anticoagulant and sedative effects.

[0034] Example 1

[0035] A traditional Chinese medicine composition for treating arthritis is composed of the following raw materials by weight: 15g of angelica dahurica, 15g of mistletoe, 15g of smilax china, 15g of radix polygoni avicularis, 15g of millettia reticulata, 15g of rhizoma liquidambar formosana, 20g of wormwood leaf, 10g of dried ginger, 15g of cibotium barometz and 15g of astragalus.

[0036] Example 2

[0037] A traditional Chinese medicine composition for treating arthritis is composed of the following raw materials by weight: 15g of Angelica dahurica, 15g of Morus alba, 15g of Herba Lycopodii, 15g of Herba Polygoni Multiflori, 15g of Herba Spatholobi, 15g of Rhizoma Spatholobi, 15g of Folium Lycopodiellae, 20g of Artemisia argyi, 10g of dried ginger, 15g of Cibotium barometz, 15g of Radix Astragali, 10g of Rhizoma Chuanxiong, 10g of Radix Clematis, 10g of Atractylodes macrocephala, 10g of Cinnamomum cassiae, and 6g of Saposhnikovia divaricata.

[0038] Example 3

[0039] A Chinese medicine preparation for treating arthritis is prepared according to the Chinese medicine formula of Example 1. Each medicinal material is soaked for 2 hours, 3000 ml of water is added for decoction, the mixture is boiled over high heat, then the heat is reduced to low heat and the decoction is continued for 0.5 hours. The residue is poured out and the mixture is placed in water at a temperature of 39-42° C. for later use.

[0040] Example 4

[0041] A Chinese medicine preparation for treating arthritis is prepared according to the Chinese medicine formula of Example 2. Each medicinal material is soaked for 2 hours, 3000 ml of water is added for decoction, boiled over high heat, then turned to low heat, and continued to be decocted for 0.5 hours. The residue is poured out and the water temperature is brought to 39-42° C. for standby use.

[0042] Example 5 - Clinical Observation on Treatment of Knee Osteoarthritis

[0043] 1 General Information

[0044] A total of 80 patients with knee osteoarthritis were collected from Heji Hospital affiliated to Changzhi Medical College and randomly divided into study group 1 and study group 2, with 40 cases in each group. There was no significant difference in general data (gender, age, and course of disease) between the two groups (P>0.05).

[0045] Inclusion criteria: Western medicine diagnostic criteria: diagnostic criteria for knee osteoarthritis in the 2018 edition of the "Guidelines for the Diagnosis and Treatment of Osteoarthritis"; Traditional Chinese medicine diagnostic criteria: syndrome differentiation criteria for cold-dampness arthralgia in the "Guidelines for the Clinical Diagnosis and Treatment of Traditional Chinese Medicine Orthopedics and Traumatology·Knee Arthralgia (Knee Osteoarthritis)"; meet the above-mentioned Chinese and Western medicine diagnostic criteria; age 40 to 80 years, disease course 1 to 20 years, regardless of gender.

[0046] Exclusion criteria: rheumatoid arthritis; knee tumor, tuberculosis; infectious arthritis; traumatic knee arthritis; gout; blood system disease; diarrhea; severe heart, liver, and kidney dysfunction.

[0047] 2 Treatment methods

[0048] Study Group 1: According to the Chinese medicine formula of Example 1; Study Group 2: According to the Chinese medicine formula of Example 2; Soak each medicinal material for 2 hours, add 3000 ml of water for decoction, boil over high heat, turn to low heat, continue to decoct for 0.5 hours, pour out the residue, put it in water at 39-42°C, and fumigate the affected area at 39-42°C. 1 dose per day, 14 days as a course of treatment, 1-3 courses of treatment.

[0049] 3 Observation items

[0050] The TCM symptoms before and after treatment were scored, and the evaluation content was formulated with reference to the Guiding Principles for Clinical Research of New Chinese Medicines, including morning stiffness, pain, and joint swelling, which were divided into four levels: none, mild, moderate, and severe, which were scored as 0, 1, 2, and 3 points respectively.

[0051] 4. Efficacy evaluation

[0052] Markedly effective: Clinical symptoms such as joint pain basically disappeared, joint movements became normal, and the TCM syndrome score decreased by >70% compared with before treatment;

[0053] Effective: Clinical symptoms such as joint pain improved, joint movement was slightly limited, and the TCM syndrome score decreased by 30% to 70% compared with before treatment;

[0054] Ineffective: TCM syndrome score decreased by <30% compared with before treatment.

[0055] Total effectiveness = marked effect + effectiveness.

[0056] Total effective rate = (number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0057] 5 Efficacy Results

[0058] Table 1 Clinical efficacy results of treating knee osteoarthritis

[0059]

[0060] The results show that the Chinese medicine preparations prepared in Examples 1-2 of the present invention have good clinical efficacy in treating knee osteoarthritis. Compared with Example 1, the Chinese medicine preparation prepared in Example 2 has a more prominent efficacy.

[0061] Example 6 - Clinical Observation on Treatment of Lumbar Disc Herniation Associated with Radiculopathy

[0062] 1 General Information

[0063] A total of 60 patients with lumbar disc herniation and radiculopathy were collected from Heji Hospital affiliated to Changzhi Medical College. They were randomly divided into study group 1 and study group 2, with 30 cases in each group. There was no significant difference in general data (gender, age, and course of disease) between the two groups (P>0.05).

[0064] Inclusion criteria: X-ray and other imaging examinations meet the relevant diagnostic criteria for lumbar disc herniation with radiculopathy, refer to the "Chinese Pain Expert Consensus on Diagnosis and Treatment of Lumbar Disc Herniation" (Chinese Medical Association Pain Branch, Spine Pain Group). Meet the above diagnostic criteria; age 20-70 years old, 1-4 years of disease course, regardless of gender. Exclusion criteria: lumbar tuberculosis; malignant tumors; liver and kidney failure; mental illness.

[0065] 2 Treatment methods

[0066] Study Group 1: According to the Chinese medicine formula of Example 1; Study Group 2: According to the Chinese medicine formula of Example 2; Soak each medicinal material for 2 hours, add 3000 ml of water for decoction, boil over high heat, turn to low heat, continue to decoct for 0.5 hours, pour out the residue, put it in water at 39-42°C, and fumigate the affected area at 39-42°C. 1 dose per day, 14 days as a course of treatment, 1-3 courses of treatment.

[0067] 3 Observation items

[0068] (1) Pain level: The patient's pain level was assessed using a numerical grading method. The patient's pain level before and after treatment was recorded. 0 to 10 points represent different degrees of pain, where 0: no pain, 1 to 3: mild pain, 3 to 6: moderate pain, and 7 to 10: severe pain.

[0069] (2) Lumbar vertebrae function: Lumbar vertebrae dysfunction index scoring table was used for evaluation. The degree of lumbar vertebrae dysfunction before and after treatment was recorded, including 10 indicators such as low back and leg pain, personal life, lifting heavy objects, walking, sitting, standing, sleeping, sexual life, social life and travel. Each indicator had 6 options, corresponding to 0, 1, 2, 3, 4, and 5 points, with a total maximum score of 50 points. The higher the score, the more severe the dysfunction.

[0070] (3) Lumbar nerve function: Lumbar nerve function scoring table was used for evaluation. The lumbar nerve function of the patient before and after treatment was recorded. The highest score was 29 points and the lowest score was 0 points. The lower the score, the more obvious the decline in nerve function.

[0071] 4. Efficacy evaluation

[0072] Markedly effective: clinical symptoms basically disappeared, pain score decreased by >70% compared with before treatment, lumbar dysfunction index score decreased by >70% compared with before treatment, and lumbar nerve function score increased by >70% compared with before treatment;

[0073] Effective: The pain score decreased by 30% to 70% compared with before treatment, the lumbar dysfunction index score decreased by 30% to 70% compared with before treatment, and the lumbar nerve function score increased by 30% to 70% compared with before treatment;

[0074] Ineffective: obvious pain, limitation of daily activities, or failure to meet the effectiveness criteria.

[0075] Total effectiveness = marked effect + effectiveness.

[0076] Total effective rate = (number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0077] 5 Efficacy Results

[0078] Table 2 Clinical efficacy results of the treatment of lumbar disc herniation with radiculopathy

[0079]

[0080] The results show that the Chinese medicine preparations prepared in Examples 1-2 of the present invention have good clinical efficacy in treating lumbar disc herniation with radiculopathy, among which Example 2 has better efficacy in treating lumbar disc herniation with radiculopathy.

[0081] Example 7

[0082] The Chinese medicine preparation prepared in Example 4 of the present invention is also used to treat scapulohumeral periarthritis, rheumatoid arthritis, ankylosing spondylitis, and cervical spondylosis, and achieves good clinical efficacy.

[0083] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating arthralgia, characterized in that: The invention comprises the following raw materials in parts by weight: 12-18 parts of angelica dahurica, 12-18 parts of mistletoe, 12-18 parts of lycopodii herba, 12-18 parts of spatholobi, 12-18 parts of millettia reticulata, 12-18 parts of fennel, 15-25 parts of wormwood, 8-12 parts of dried ginger, 12-18 parts of cibotium barometz and 12-18 parts of astragalus.

2. The Chinese medicine composition for treating arthralgia according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 15 parts of angelica dahurica, 15 parts of mistletoe, 15 parts of smilax china, 15 parts of smilax china, 15 parts of millettia reticulata, 15 parts of fennel, 20 parts of wormwood leaves, 10 parts of dried ginger, 15 parts of cibotium barometz and 15 parts of astragalus.

3. The Chinese medicine composition for treating arthralgia according to claim 1, characterized in that: It also includes the following raw materials: Chuanxiong, Clematis, Atractylodes, Cassia twig, and Saposhnikovia divaricata. By weight, there are 12-18 parts of Angelica dahurica, 12-18 parts of Viscum album, 12-18 parts of Lycopodiella ciliata, 12-18 parts of Smilax glabra, 12-18 parts of Polygonum multiflorum, 12-18 parts of Spatholobus suberectus, 15-25 parts of Artemisia argyi, 8-12 parts of dried ginger, 12-18 parts of Cibotium barometz, 12-18 parts of Astragalus, 8-12 parts of Chuanxiong, 8-12 parts of Clematis, 8-12 parts of Atractylodes, 8-12 parts of Cassia twig, and 4-6 parts of Saposhnikovia divaricata.

4. The Chinese medicine composition for treating arthralgia according to claim 3, characterized in that: The invention comprises the following raw materials in parts by weight: 15 parts of angelica dahurica, 15 parts of mistletoe, 15 parts of smilax china, 15 parts of spatholobi, 15 parts of millettia reticulata, 15 parts of fennel, 20 parts of wormwood, 10 parts of dried ginger, 15 parts of cibotium barometz, 15 parts of astragalus, 10 parts of ligusticum chuanxiong, 10 parts of clematis, 10 parts of atractylodes macrocephala, 10 parts of cassia twig and 6 parts of siler.

5. A Chinese medicine preparation for treating arthralgia, characterized in that: Prepared according to the Chinese medicine composition according to any one of claims 1-4.

6. The Chinese medicine preparation for treating arthralgia according to claim 5, characterized in that: Soak each medicinal material for 1.5-2.5h, add 2500-3500ml of water for decoction, bring to a boil over high heat, then turn to low heat and continue decocting for 0.4-0.6h. Pour out the residue and let the water cool to 39-42℃ for later use.

7. Use of the Chinese medicine composition according to any one of claims 1 to 4 in the preparation of medicines for treating arthralgia.

8. The use according to claim 7, characterized in that: The traditional Chinese medicine composition is used in preparing medicine for treating lumbar disc herniation with nerve root compression and knee osteoarthritis.

9. The use according to claim 7, characterized in that: The Chinese medicine composition is used in preparing medicines for treating lumbar disc herniation with nerve root compression, knee osteoarthritis, scapulohumeral periarthritis, rheumatoid arthritis, ankylosing spondylitis and cervical spondylosis.