Interventional ventricular assist oxygenation device

Abstract

The application provides an interventional ventricular auxiliary oxygen generation device, a blood flow channel crosses an aortic valve into a left ventricle from an ascending aorta, a blood inlet of the blood flow channel is located in the left ventricle, a blood outlet is located in the ascending aorta, a first conveying pipe and a second conveying pipe convey hydrogen peroxide and catalase into the left ventricle to generate oxygen and water through reaction, and a pumping unit pumps oxygen-rich blood in the left ventricle to the ascending aorta. The oxygen generation function is added to the ventricular auxiliary device, the oxygen-rich blood in the ventricle is pumped to the ascending aorta through the ventricular auxiliary device, which directly improves the myocardial hypoxia condition and helps the heart recover, and on the other hand, the oxygen-rich blood is pumped into the ascending aorta and directly participates in the systemic circulation, thereby directly and quickly improving the oxygen supply condition of the systemic circulation.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to an interventional ventricular assist oxygenation device. BACKGROUND

[0002] The interventional ventricular assist device is generally a micro axial flow pump which is percutaneously inserted into the human body, wherein the inlet of the micro axial flow pump is placed in the left ventricle and the outlet is placed in the ascending aorta. When the micro axial flow pump is running, blood is pumped from the left ventricle to the ascending aorta, thereby providing pumping power for heart failure patients. For heart failure patients, the myocardial contractile function is degenerative, often accompanied by pulmonary insufficiency, which is mutually influenced. This results in hypoxia of the myocardium and systemic blood of the patient. Although the interventional ventricular assist device in the prior art can assist the left ventricle to pump blood, it cannot directly improve the hypoxia. SUMMARY

[0003] The purpose of the present application is to provide an interventional ventricular assist oxygenation device which can assist in pumping blood while supplementing oxygen to the blood in the left ventricle.

[0004] In order to achieve the above-mentioned purpose, the technical scheme adopted by the present application is as follows: an interventional ventricular assist oxygenation device, comprising a pumping unit and a blood flow channel, the blood flow channel crosses the aortic valve from the ascending aorta into the left ventricle, and the blood inlet of the blood flow channel is located in the left ventricle and the blood outlet is located in the ascending aorta, and the device is further provided with a first delivery tube and a second delivery tube, the first delivery tube and the second delivery tube respectively deliver hydrogen peroxide and catalase and react to generate oxygen and water in the left ventricle, the oxygen is released into the blood in the left ventricle, and the pumping unit pumps the oxygen-rich blood in the left ventricle to the ascending aorta.

[0005] Further, the blood flow channel comprises a sleeve and blood inflow cages and blood outflow cages fixed at both ends of the sleeve, the blood inflow cages are provided with windows to form the blood inlets, the blood outflow cages are provided with windows to form the blood outlets, and the blood inflow cages are provided with micro-reaction chambers, the hydrogen peroxide and catalase delivered by the first delivery tube and the second delivery tube react chemically in the micro-reaction chambers and release oxygen.

[0006] Further, the first delivery tube is a tube cluster formed by a plurality of hollow fiber tubes, and the second delivery tube is also a tube cluster formed by a plurality of hollow fiber tubes, and the plurality of hollow fiber tubes of the first delivery tube and the plurality of hollow fiber tubes of the second delivery tube which communicate with the micro-reaction chambers are arranged in a staggered manner.

[0007] Further, the pumping unit comprises a motor and an impeller, the blood outlet cage is arranged on the outer periphery of the impeller and is fixedly connected with the distal end of the motor, the proximal end of the motor is connected with the extracorporeal control system through a catheter, a restraint member is arranged in the catheter near the motor, the restraint member is in the shape of a circular plate, a through hole corresponding to each hollow fiber tube is formed in the circular plate, and the multiple hollow fiber tubes of the first delivery tube and the multiple hollow fiber tubes of the second delivery tube are staggered and inserted into the through holes.

[0008] Further, the first delivery tube and the second delivery tube are single-lumen tubes, and a dispersion unit is arranged between the two single-lumen tubes and the micro-reaction chamber, the dispersion unit comprises a shell, a joint is arranged at the proximal end of the shell, the inner cavity of the joint is divided into two storage cavities that are isolated from each other by a partition plate, and the two storage cavities are respectively communicated with the first delivery tube and the second delivery tube, a tube cluster formed by multiple hollow fiber tubes is arranged in the shell, the proximal end of the tube cluster is communicated with the two storage cavities, and the distal end of the tube cluster is constrained in a restraint member arranged at the other end of the shell, at the restraint member, the multiple hollow fiber tubes communicated with the first delivery tube and the multiple hollow fiber tubes communicated with the second delivery tube are arranged in a staggered manner, hydrogen peroxide and catalase enter the hollow fiber tubes and then enter the micro-reaction chamber from the distal end of the hollow fiber tubes to perform a chemical reaction.

[0009] Further, the pumping unit comprises a motor and an impeller, the blood outlet cage is arranged on the outer periphery of the impeller and is fixedly connected with the distal end of the motor, the proximal end of the motor is connected with the extracorporeal control system through a catheter, the dispersion unit is arranged in the catheter near the tail end of the motor.

[0010] Further, the two clusters of hollow fiber tubes are combined into one delivery tube from the distal end of the catheter, the delivery tube reaches the blood inlet cage from the outer wall of the motor, the inner wall of the sleeve, and is communicated with the micro-reaction chamber, a groove is formed in the outer wall of the motor along the axial direction of the motor, and the delivery tube is embedded in the groove and fixed by epoxy resin glue.

[0011] Further, the sleeve comprises a spring tube and inner and outer membranes arranged on the inner and outer sides of the spring tube, the spring tube is formed by winding a shape memory wire, a channel is arranged between the spring tube and the outer membrane, and the delivery tube passes through the channel.

[0012] Further, a flat surface is arranged on the outer wall of the blood inlet cage along the axial direction of the blood inlet cage, the micro-reaction chamber is fixed on the flat surface, a protective cover is arranged on the outer cover of the micro-reaction chamber, the outer wall of the protective cover is designed as an arc-shaped flow guide surface extending from the distal end to the proximal end, and the two ends of the protective cover are also fixed on the flat surface.

[0013] Further, the micro-reaction chamber is a micro-pipe type reactor, the reaction channel in the micro-reaction chamber has a diameter of 10-100 um, a diaphragm is arranged at the outlet of the reactor, and the diaphragm allows oxygen and water to pass through and prevents blood from passing through.

[0014] In the above scheme, the oxygen generating function is added to the ventricular assist device, hydrogen peroxide and catalase are used to produce oxygen, the reaction product is water and oxygen, the oxygen is mixed into the blood in the left ventricle to supplement the oxygen in the blood, and the water is also needed in the human body, so it will not cause any harm to the human body. The oxygen-rich blood in the ventricle is pumped into the aorta by the ventricular assist device, which directly improves the myocardial hypoxia and helps the heart recover, and the oxygen-rich blood is pumped into the ascending aorta to participate in the systemic circulation, thereby directly and quickly improving the oxygen supply of the systemic circulation. BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device;

[0016] Figure 2 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device; Figure 1

[0017] Figure 3 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device; Figure 1

[0018] Figure 4 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device; Figure 1

[0019] Figure 5 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device;

[0020] Figure 6 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device;

[0021] Figure 7 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device; Figure 1

[0022] Figure 8 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device; Figure 1

[0023] Figure 9 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device;

[0024] Figure 10 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device;

[0025] Figure 11 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device; Figure 10

[0026] Figure 12 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device;

[0027] Figure 13 It is a schematic diagram of the overall structure of the ventricular assist oxygen generating device; Figure 12 ​​​​​​​DETAILED DESCRIPTION

[0028] For the sake of convenience, we first define the orientation: "proximal" and "proximally" refer to the side close to the operator / physician, and "distal" and "distally" refer to the side away from the operator / physician, i.e., the side close to the heart. The following description is made in conjunction with Figures 1-13 The present application is further described in detail.

[0029] Referring to Figures 1-2 As shown in the figure, an interventional ventricular assist oxygen generation device includes a pumping unit 10 and a blood flow passage 20, the blood flow passage 20 crosses the aortic valve from the ascending aorta into the left ventricle, and the blood inlet a of the blood flow passage is located in the left ventricle, and the blood outlet b is located in the ascending aorta. The device is also provided with a first delivery pipe 31 and a second delivery pipe 32, the first delivery pipe 31 and the second delivery pipe 32 respectively deliver hydrogen peroxide and catalase and react to generate oxygen and water in the left ventricle, the oxygen is released into the blood in the left ventricle, and the pumping unit 10 pumps the oxygen-rich blood in the left ventricle to the ascending aorta.

[0030] In the above scheme, the oxygen generation function is added to the ventricular assist device, oxygen is prepared by using hydrogen peroxide and catalase, the reaction product is water and oxygen, the oxygen is mixed into the blood in the left ventricle to supplement the oxygen for the blood, and the water is also needed in the human body, so it will not cause any harm to the human body. The oxygen-rich blood in the ventricle is pumped to the aorta by the ventricular assist device, which directly improves the myocardial hypoxia condition and helps the heart recover, and on the other hand, the oxygen-rich blood is pumped into the ascending aorta to directly participate in the systemic circulation, thereby directly and quickly improving the oxygen supply condition of the systemic circulation.

[0031] The hydrogen peroxide and catalase undergo a disproportionation reaction:

[0032]

[0033] In this way, two molecules meet and collide on the active center of CAT in turn, and a reaction of disproportionation occurs to generate two molecules and one molecule.

[0034] In addition, directly supplementing oxygen into the left ventricle can change the blood composition and pressure distribution in the ventricular cavity, thereby improving the aortic regurgitation condition; at the same time, by accurately controlling the generation amount of oxygen, it will not affect the hemodynamics inside the heart.

[0035] The blood flow channel 20 comprises a cannula 21 and a blood inflow cage 22 and a blood outflow cage 23 fixed at both ends of the cannula 21, the blood inflow cage 22 is provided with a window constituting a blood inlet a, the blood outflow cage 23 is provided with a window constituting a blood outlet b, the micro-reaction chamber 40 is arranged on the blood inflow cage 22, and the hydrogen peroxide and catalase delivered by the first delivery pipe 31 and the second delivery pipe 32 react in the micro-reaction chamber 40 to release oxygen. The blood inflow cage 22 is located in the left ventricle, the blood outflow cage 23 is located in the ascending aorta, the blood inflow cage 22 is made of metal and has a certain rigidity, the micro-reaction chamber 40 is fixed on the blood inflow cage 22, the connection is firm, and the position is stable and reliable. The pumping unit 10 acts to suck the oxygen-rich blood in the left ventricle from the blood inlet a on the blood inflow cage 22 into the inner cavity of the cannula 21, and then injects the oxygen-rich blood into the aorta from the blood outlet b on the blood outflow cage 23.

[0036] During the delivery of hydrogen peroxide and catalase, we hope that it can achieve ultra-small flow delivery, and that hydrogen peroxide and catalase can be quickly mixed and reacted when they reach the micro-reaction chamber 40 in the ventricle. In order to achieve the above purpose, two technical solutions provided in Embodiments 1 and 2 are included but not limited to. Embodiment 1

[0037] Referring to Figures 3-6 As shown, the first delivery pipe 31 is a tube cluster formed by a plurality of hollow fiber tubes, the second delivery pipe 32 is also a tube cluster formed by a plurality of hollow fiber tubes, and the plurality of hollow fiber tubes of the first delivery pipe 31 and the plurality of hollow fiber tubes of the second delivery pipe 32 are arranged in a staggered manner and communicate with the micro-reaction chamber 40. It should be noted that the hollow fiber tube here has no permeability and only delivers liquid. In this embodiment, the first delivery pipe 31 and the second delivery pipe 32 are tube clusters formed by a plurality of hollow fiber tubes, which can deliver a small amount of hydrogen peroxide and catalase, and the plurality of hollow fiber tubes of the first delivery pipe 31 and the plurality of hollow fiber tubes of the second delivery pipe 32 are arranged in a staggered manner at the position of the micro-reaction chamber 40, thereby ensuring that hydrogen peroxide and catalase can be uniformly and quickly mixed and reacted to generate oxygen and water. The hollow fiber tube can be an ultra-small diameter hollow fiber tube with an inner diameter of 10-50 um, which can deliver a small amount of solution and ensure that a small amount of oxygen is generated, which can supplement the oxygen in the ventricle without adversely affecting the hemodynamics.

[0038] In order to realize the interlaced arrangement of the hollow fiber tubes, the pumping unit 10 comprises a motor 11 and an impeller 12, the blood outlet cage 23 is arranged on the outer periphery of the impeller 12 and is fixedly connected with the distal end of the motor 11, the proximal end of the motor 11 is connected with the extracorporeal control system through a conduit 50, a constraint member 51 is arranged in the conduit 50 close to the motor 11, the constraint member 51 is in the shape of a circular plate, a through hole 511 corresponding to each hollow fiber tube is formed in the circular plate, and the hollow fiber tubes of the first delivery tube 31 and the hollow fiber tubes of the second delivery tube 32 are interlacedly inserted into the through holes 511. After the rearrangement of the constraint member 51, the hollow fiber tubes for delivering hydrogen peroxide and the hollow fiber tubes for delivering catalase are interlacedly distributed, preferably, a single hollow fiber tube for delivering hydrogen peroxide is surrounded by hollow fiber tubes for delivering catalase, and a single hollow fiber tube for delivering catalase is surrounded by hollow fiber tubes for delivering hydrogen peroxide, so as to ensure that the hydrogen peroxide and the catalase are uniformly mixed and rapidly reacted. The hollow fiber tubes passing through the through holes 511 can be regarded as a whole cluster, the outer periphery of which is preferably covered with a film or an ultrathin tube to minimize the outer diameter of the delivery tube 32. Since there are fiber optic lines and flushing liquid tubes (not marked in the figure) in the conduit 50, the constraint member 51 also needs to be correspondingly provided with through holes for the lines to pass through, which will not be described in detail here. Example 2

[0039] Referring to Figures 7-9As shown, the first delivery tube 31 and the second delivery tube 32 are single-lumen tubes, and a dispersion unit 60 is arranged between the two single-lumen tubes and the micro-reaction chamber 40. The dispersion unit 60 includes a housing 61, and a connector 62 is arranged at the proximal end of the housing 61. The inner cavity of the connector 62 is divided into two mutually isolated liquid storage cavities by a partition, and the two liquid storage cavities are respectively communicated with the first delivery tube 31 and the second delivery tube 32. A plurality of hollow fiber tubes are arranged in the housing 61 to form a tube cluster. The proximal end of the tube cluster is communicated with the two liquid storage cavities, and the distal end of the tube cluster is constrained in a constraint member 63 arranged at the other end of the housing 61. At the constraint member 63, the plurality of hollow fiber tubes communicated with the first delivery tube 31 and the plurality of hollow fiber tubes communicated with the second delivery tube 32 are arranged in a staggered manner. Hydrogen peroxide and catalase enter the hollow fiber tubes and then enter the micro-reaction chamber 40 from the distal end of the hollow fiber tubes to perform a chemical reaction. In this embodiment, the first delivery tube 31 and the second delivery tube 32 are single-lumen tubes. The proximal end of the single-lumen tube is connected with an extracorporeal hydrogen peroxide and catalase storage tank, and the distal end of the single-lumen tube disperses the liquid in the hollow fiber tubes through the dispersion unit 60 to perform micro and uniform delivery. The hollow fiber tubes in the housing 61 are arranged in a staggered manner to separate and stagger the positions of the hollow fiber tubes for delivering hydrogen peroxide and the hollow fiber tubes for delivering catalase. The purpose is to ensure that hydrogen peroxide and catalase are mixed uniformly and react rapidly. That is, around a single hollow fiber tube for delivering hydrogen peroxide, there are hollow fiber tubes for delivering catalase, and around a single hollow fiber tube for delivering catalase, there are hollow fiber tubes for delivering hydrogen peroxide.

[0040] The pumping unit 10 includes a motor 11 and an impeller 12. The blood flow out of the cage 23 is arranged on the outer periphery of the impeller 12 and is fixedly connected with the distal end of the motor 11. The proximal end of the motor 11 is connected with an extracorporeal control system through a catheter 50. The dispersion unit 60 is arranged in the catheter 50 near the tail end of the motor 11. Considering that the dispersion unit 60 has a certain diameter, it is better not to be arranged on the pumping assembly 10 and the blood flow channel 20 to avoid increasing the outer diameter of the entire device. Therefore, the dispersion unit 60 is arranged in the catheter 50, which does not increase the outer diameter of the entire ventricular assist device and also increases the strength of the catheter 50 at the tail of the motor 11, which is beneficial to the pushing of the motor 11.

[0041] In the embodiment 1, the internal part of the catheter 50 only needs to be provided with the simple structure of the constraint 51 to achieve the rearrangement of the hollow fiber tubes in the first delivery tube 31 and the second delivery tube 32, which is simple in structure and convenient to assemble. In the embodiment 2, only the internal part of the catheter 50 near the motor 11 needs to be provided with the dispersion unit 60, and the first delivery tube 31 and the second delivery tube 32 in the catheter 50 near the dispersion unit 60 are both single-cavity tubes with small diameters. The external catheter has a small diameter and a certain bending degree, which can adapt to the curved path of the human blood vessels. In the entire length direction of the catheter 50, only the catheter segment provided with the dispersion unit 60 needs to be slightly increased in diameter for the installation of the dispersion unit 60. If the outer diameter of the dispersion unit 60 is set to be small enough, the diameter of the catheter segment does not need to be increased and can be consistent with the diameters of the other catheter segments. However, due to the setting of the dispersion unit 60, the stiffness of the catheter 50 near the proximal end of the motor 11 is increased, which can better push the motor 11 and the components distal to the motor.

[0042] In both the embodiment 1 and the embodiment 2, the two clusters of hollow fiber tubes are combined into one cluster of delivery tubes 30 from the distal end of the catheter 50. Here, the one cluster of delivery tubes 30 refers to the spatial combination of the two separate clusters of hollow fiber tubes, and the number of hollow fiber tubes does not change. When the two separate clusters of hollow fiber tubes extend distally, on the one hand, they are not convenient to arrange, and on the other hand, they also occupy a large space. When the two clusters of hollow fiber tubes are combined into one cluster, it is convenient to extend distally and arrange, and the space occupied is small. The outer wall of the delivery tube 30 can be covered with a film to minimize the outer diameter and reduce the outer diameter of the entire auxiliary device. The delivery tube 30 reaches the blood inflow cage 22 and communicates with the micro-reaction chamber 40 from the outer wall of the motor 11 and the inner wall of the sleeve 21. The outer wall of the motor 11 is provided with a groove along the axial direction, and the delivery tube 30 is embedded in the groove and fixed with epoxy resin glue, so as to maintain the small size and smoothness of the motor 11.

[0043] How to arrange the delivery tube 30 from the sleeve 21 is a problem that needs to be considered. As shown in Figures 10-11 The sleeve 21 includes a spring tube 211 and inner and outer films 212 and 213 covering the inner and outer sides of the spring tube 211. The spring tube 211 is made of shape memory wire (such as nickel-titanium alloy wire) winding. A channel 214 is arranged between the spring tube 211 and the outer film 213, and the delivery tube 30 passes through the channel 214. In this way, the delivery tube 30 passes through the inner wall of the sleeve 21, on the one hand, to ensure the smoothness of the inner and outer walls of the sleeve 21, and on the other hand, to fix the position of the delivery tube 30 and prevent it from being twisted to hinder the delivery of hydrogen peroxide and catalase. Moreover, the delivery tube 30 is protected in the channel 214 to prevent the blood flow from affecting the delivery of hydrogen peroxide and catalase, thereby ensuring the quantitative and stable delivery of hydrogen peroxide and catalase.

[0044] Considering the convenience of inserting into blood vessels and the low damage to blood vessels, as shown in Figures 12-13 As shown in the figure, a plane is arranged on the outer wall of the blood inflow cage 22 along the axial direction, the micro-reaction chamber 40 is fixed on the plane, the reliability of the connection between the micro-reaction chamber 40 and the blood inflow cage 22 is increased, the outer cover of the micro-reaction chamber 40 is provided with a protective cover 41, the outer wall of the protective cover 41 is configured as an arc-shaped flow guide surface extending from the distal end to the proximal end, and the two ends of the protective cover 41 are also fixed on the plane. As shown in the figure, the distal end of the protective cover 41 with a C-shaped structure has no notch, preventing the blood from directly impacting the micro-reaction chamber 40, and the two sides are open, avoiding hindering the release of oxygen, and the proximal end is provided with a notch for the delivery tube 30 to pass through. At the same time, the arc-shaped flow guide surface can guide the blood to move proximally, and the smooth outer surface can also reduce the damage to the blood vessels and other tissues.

[0045] Further, the micro-reaction chamber 40 is a micro-pipe type reactor, the reaction channel in the micro-reaction chamber 40 has a diameter of 10-100 um, ensuring that the generation of oxygen is rapid, and the amount of oxygen generated each time is small, thereby avoiding causing excessive generation of oxygen and triggering other adverse reactions. A diaphragm is arranged at the outlet of the reactor, the diaphragm allows oxygen and water to pass through and prevents blood from passing through.

[0046] Of course, for those skilled in the art, the present application is not limited to the details of the above-mentioned exemplary embodiments, but also includes the same or similar structures that can be realized in other specific forms without departing from the spirit or essential characteristics of the present application. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting, the scope of the present application is defined by the appended claims rather than the above description, and therefore all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present application. Any reference signs in the claims should not be regarded as limiting the claims involved.

[0047] In addition, it should be understood that although the present specification is described in terms of embodiments, not every embodiment contains only one independent technical solution, and the description manner of the specification is only for the sake of clarity, those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that those skilled in the art can understand.

Claims

1. An interventional ventricular assist device, comprising a pumping unit (10) and a blood flow channel (20) which extends from the ascending aorta across the aortic valve into the left ventricle, the blood inlet (a) of the blood flow channel being located in the left ventricle and the blood outlet (b) being located in the ascending aorta, characterized in that: The device is also provided with a first delivery pipe (31) and a second delivery pipe (32), the first delivery pipe (31) and the second delivery pipe (32) respectively deliver hydrogen peroxide and catalase and react to generate oxygen and water in the left ventricle, the oxygen is released into the blood in the left ventricle, and the pumping unit (10) pumps the oxygen-rich blood in the left ventricle to the ascending aorta; The blood flow channel (20) comprises a sleeve (21) and blood inflow cages (22) and blood outflow cages (23) fixed at both ends of the sleeve (21), the blood inflow cages (22) are provided with windows to form blood inlet ports (a), the blood outflow cages (23) are provided with windows to form blood outlet ports (b), and the micro-reaction chambers (40) are arranged on the blood inflow cages (22); hydrogen peroxide and catalase delivered by the first delivery pipe (31) and the second delivery pipe (32) react in the micro-reaction chambers (40) and release oxygen. The outer wall of the blood inflow cage (22) is provided with a plane along the axial direction, the micro-reaction chambers (40) are fixed on the plane, the outer wall of the protective cover (41) is formed into an arc-shaped flow guide surface extending from the distal end to the proximal end, and the two ends of the protective cover (41) are also fixed on the plane.

2. The interventional ventricular assist device of claim 1, wherein: The first delivery pipe (31) is in the form of a tube cluster composed of a plurality of hollow fiber tubes, the second delivery pipe (32) is also in the form of a tube cluster composed of a plurality of hollow fiber tubes, and the plurality of hollow fiber tubes of the first delivery pipe (31) and the plurality of hollow fiber tubes of the second delivery pipe (32) are arranged in a staggered manner.

3. The interventional ventricular assist device of claim 2, wherein: The pumping unit (10) comprises a motor (11) and an impeller (12), the blood outflow cage (23) is arranged on the outer periphery of the impeller (12) and is fixedly connected to the distal end of the motor (11), the proximal end of the motor (11) is connected to an extracorporeal control system through a catheter (50), the first delivery pipe (31) and the second delivery pipe (32) are arranged in the catheter (50) and extend to the left ventricle in the distal direction, a restraint member (51) is arranged in the catheter (50) near the motor (11), the restraint member (51) is in the form of a circular plate, a plurality of through holes (511) corresponding to the hollow fiber tubes are arranged on the circular plate, and the plurality of hollow fiber tubes of the first delivery pipe (31) and the plurality of hollow fiber tubes of the second delivery pipe (32) are arranged in the through holes (511) in a staggered manner.

4. The interventional ventricular assist oxygenation device of claim 1, wherein: The first delivery tube (31) and the second delivery tube (32) are single-cavity tubes, and a dispersion unit (60) is arranged between the two single-cavity tubes and the micro-reaction chamber (40). The dispersion unit (60) comprises a shell (61), and a joint (62) is arranged at the proximal end of the shell (61). The inner cavity of the joint (62) is divided into two mutually isolated liquid storage cavities by a partition plate, and the two liquid storage cavities are communicated with the first delivery tube (31) and the second delivery tube (32) respectively. A plurality of hollow fiber tubes are arranged in the shell (61) to form a tube cluster. The proximal end of the tube cluster is communicated with the two liquid storage cavities, and the distal end of the tube cluster is constrained in a constraint member (63) arranged at the other end of the shell (61). At the constraint member (63), the plurality of hollow fiber tubes communicated with the first delivery tube (31) and the plurality of hollow fiber tubes communicated with the second delivery tube (32) are arranged in a staggered manner. Hydrogen peroxide and catalase enter the hollow fiber tubes and react in the micro-reaction chamber (40) from the distal end of the hollow fiber tubes.

5. The interventional ventricular assist device of claim 4, wherein: The pumping unit (10) comprises a motor (11) and an impeller (12). The blood flow-out cage (23) is arranged on the outer periphery of the impeller (12) and is fixedly connected with the distal end of the motor (11). The proximal end of the motor (11) is connected with an extracorporeal control system through a catheter (50). The dispersion unit (60) is arranged in the inner cavity of the catheter (50) near the tail end of the motor (11).

6. The paracorporeal ventricular assist oxygenation device of claim 3 or 5, wherein: The two tube clusters of hollow fiber tubes are combined into a delivery tube (30) from the distal end of the catheter (50). The delivery tube (30) reaches the blood flow-in cage (22) from the outer wall of the motor (11) and the inner wall of the sleeve (21) and is communicated with the micro-reaction chamber (40) arranged on the outer wall of the blood flow-in cage (22). A groove is arranged on the outer wall of the motor (11) along the axial direction. The delivery tube (30) is embedded in the groove and is fixed by epoxy resin glue.

7. The interventional ventricular assist oxygenation device of claim 6, wherein: The sleeve (21) comprises a spring tube (211) and inner and outer membranes (212) and (213) arranged on the inner and outer sides of the spring tube (211). The spring tube (211) is wound by shape memory wire. A passage (214) is arranged between the spring tube (211) and the outer membrane (213). The delivery tube (30) passes through the passage (214).

8. The interventional ventricular assist oxygenation device of claim 1, wherein: The micro-reaction chamber (40) is a micro-pipe type reactor. The reaction channel in the micro-reaction chamber (40) has a diameter of 10-100 um. A diaphragm is arranged at the outlet of the reactor. The diaphragm allows oxygen and water to pass through and prevents blood from passing through.

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