Driving method of transcranial magnetic stimulation three-dimensional coil device

Abstract

The invention provides a driving method of a transcranial magnetic stimulation three-dimensional coil device. The method includes: determining first and second signal peak values corresponding to a specified rotating magnetic field direction, wherein the first and second signal peak values respectively correspond to first and second coils of the plurality of coils; providing a first pulse current signal with a first signal peak value to the first coil, wherein the first pulse current signal excites the first coil to provide a first magnetic field; a second pulse current signal with a second signal peak value is provided for a second coil, the second pulse current signal excites the second coil to provide a second magnetic field, and the first magnetic field and the second magnetic field form a rotating magnetic field with a specified rotating magnetic field direction;

Description

Technical Field

[0001] The present invention relates to a transcranial magnetic stimulation (TMS) technology, and in particular to a driving method of a transcranial magnetic stimulation three-dimensional coil device. Background Art

[0002] In the prior art, it is a common medical method to treat depression patients or other brain diseases through transcranial magnetic stimulation (TMS) technology.

[0003] For example, U.S. Patent Publication No. US20210228898A1 discloses an 8-shaped TMS device, which includes an electromagnet, a driving circuit electrically coupled to the electromagnet, and a controller configured to control the driving circuit to provide current to the electromagnet to generate a pulsed magnetic field.

[0004] However, the 8-shaped TMS device can only be used to stimulate a single brain region. In other words, if different brain regions are to be stimulated, the relevant personnel need to move the TMS device to the corresponding position. Moreover, when performing multi-brain region treatment for comorbidities, the relevant personnel still need to replace the coils of different configurations for this TMS device.

[0005] It can be seen from this that the existing TMS device is not convenient to use. Summary of the invention

[0006] In view of this, the present invention provides a driving method for a transcranial magnetic stimulation three-dimensional coil device, which can be used to solve the above technical problems.

[0007] An embodiment of the present invention provides a driving method for a transcranial magnetic stimulation three-dimensional coil device, which is suitable for a driving device, wherein the transcranial magnetic stimulation three-dimensional coil device includes multiple coils, and the central axes of each coil are perpendicular to each other. The method includes: determining a first signal peak value and a second signal peak value corresponding to a specified rotating magnetic field direction, wherein the first signal peak value and the second signal peak value correspond to a first coil and a second coil among the multiple coils, respectively; providing a first pulse current signal with a first signal peak value to the first coil, wherein the first pulse current signal excites the first coil to provide a first magnetic field; providing a second pulse current signal with a second signal peak value to the second coil, wherein the second pulse current signal excites the second coil to provide a second magnetic field, and the first magnetic field and the second magnetic field form a rotating magnetic field with a specified rotating magnetic field direction. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] The accompanying drawings are included to provide a further understanding of the present invention and are incorporated in and constitute a part of this specification. The drawings illustrate embodiments of the present invention and together with the description serve to explain the principles of the present invention.

[0009] Figures 1A to 1D 1 is a diagram showing different views of a transcranial magnetic stimulation stereo coil device according to an embodiment of the present invention;

[0010] Figure 2 is based on Figures 1A to 1D Schematic diagram of different transcranial magnetic stimulation electric fields shown;

[0011] Figure 3A and Figure 3B 1 is a diagram showing different views of a transcranial magnetic stimulation stereo coil device according to an embodiment of the present invention;

[0012] Figure 4 is based on Figure 3A and Figure 3B A schematic diagram of a transcranial magnetic stimulation stereocoil device is shown;

[0013] Figure 5 is a schematic diagram showing a transcranial magnetic stimulation stereoscopic coil device driven by a driving device according to an embodiment of the present invention;

[0014] Figure 6 is a flow chart of a driving method of a transcranial magnetic stimulation three-dimensional coil device according to an embodiment of the present invention;

[0015] Figure 7 It is a waveform diagram according to Table 1;

[0016] Figure 8 is a schematic diagram of the first and second pulse current signals shown in Table 1;

[0017] Fig. 9 is an application scenario diagram according to an embodiment of the present invention;

[0018] Fig.10 is an application scenario diagram according to an embodiment of the present invention;

[0019] Fig.11 It is an application scenario diagram shown according to an embodiment of the present invention. DETAILED DESCRIPTION

[0020] Please refer to Figures 1A to 1D , which are different views of a transcranial magnetic stimulation three-dimensional coil device according to an embodiment of the present invention.

[0021] exist Figures 1A to 1DIn the embodiment, the transcranial magnetic stimulation three-dimensional coil device 10 includes a first coil 11, a second coil 12 and a third coil 13. The first coil 11 has a first central axis A1 and a central area CA. The second coil 12 has a second central axis A2, and the second coil 12 is located in the central area CA. The third coil 13 has a third central axis A3 and is located on one side of the first coil 11, wherein the first central axis A1, the second central axis A2 and the third central axis A3 are perpendicular to each other.

[0022] exist Figure 1B In the embodiment, the first coil 11 has an outer layer sub-coil 111 and an inner layer sub-coil 112, and the second coil 12 is located between the outer layer sub-coil 111 and the inner layer sub-coil 112. Figure 1D In the figure, the second coil 12 has an outer sub-coil 121 and an inner sub-coil 122, and the outer sub-coil 121 of the second coil 12 is between the outer sub-coil 111 and the inner sub-coil 112, and the inner sub-coil 112 of the first coil 11 is between the outer sub-coil 121 and the inner sub-coil 122 of the second coil 12, but it is not limited to this.

[0023] In one embodiment, the first coil 11 has a first center point C1, the second coil 12 has a second center point C2, and a first distance between the first center point C1 and the second center point C2 is not greater than a first threshold value. Figure 1B , Figure 1D In the embodiment, the first center point C1 may coincide with / be the same as the second center point C2. In different embodiments, the first threshold value may be set to any value that can be considered to make the first center point C1 close enough to the second center point C2 according to the designer's needs, but is not limited thereto.

[0024] In one embodiment, the third coil 13 has a third center point C3, and the second distance D2 between the third center point C3 and the first center point C1 or the third distance D3 between the third center point C3 and the second center point C2 is within a preset range, wherein the preset range is based on the outer diameter OD1 of the first coil 11 and the thickness T3 of the third coil 13.

[0025] In one embodiment, the upper limit of the preset range is, for example, the sum of the outer diameter OD1 and half of the thickness T3, and the lower limit of the preset range is, for example, the outer diameter OD1 minus half of the thickness T3, but is not limited thereto.

[0026] exist Figures 1A to 1D In the scenario, since the first center point C1 is assumed to coincide with the second center point C2, the second distance D2 between the third center point C3 and the first center point C1 may be equal to the third distance D3 between the third center point C3 and the second center point C2, but is not limited thereto.

[0027] In addition, Figures 1A to 1D In the scenario, it is assumed that the outer diameter D1 is equal to the second distance D2 (and the third distance D3), but it is not limited thereto.

[0028] In one embodiment, the number of layers of the first coil 11 is 2, and the number of turns of each layer of the first coil 11 is 10 turns or 8 turns.

[0029] In one embodiment, the number of layers of the second coil 12 is 2, and the number of turns of each layer of the second coil 12 is 12 turns or 10 turns.

[0030] In one embodiment, the number of layers of the third coil 13 is 4, and the number of turns of each layer of the third coil 13 is 6 turns, 5 turns, 4 turns or 3 turns.

[0031] In one embodiment, a coil diameter of at least one of the first coil 11 , the second coil 12 , and the third coil 13 is less than 3.5 mm.

[0032] In one embodiment, the coil resistance of at least one of the first coil 11 , the second coil 12 and the third coil 13 is less than 45 mΩ.

[0033] In one embodiment, the coil inductance of at least one of the first coil 11 , the second coil 12 and the third coil 13 is less than uH.

[0034] In one embodiment, at least one of the first coil 11 , the second coil 12 and the third coil 13 is made of Litz wire.

[0035] In one embodiment, the wire diameter of at least one of the first coil 11 , the second coil 12 and the third coil 13 is 30 American Wire Gauge.

[0036] In one embodiment, the first coil 11 is excited to provide a first electric field, the second coil 12 is excited to provide a second electric field, and the third coil 13 is excited to provide a third electric field, and the first electric field, the second electric field and the third electric field cooperate to form a transcranial magnetic stimulation electric field corresponding to the transcranial magnetic stimulation three-dimensional coil device 10.

[0037] Please refer to Figure 2 , which is based on Figures 1A to 1D Schematic diagram of different transcranial magnetic stimulation electric fields. Figure 2 In the embodiment, scenario 211 is, for example, a scenario in which only the first coil 11 of the transcranial magnetic stimulation three-dimensional coil device 10 is excited to provide a first electric field. Since the second coil 12 and the third coil 13 are not excited, the transcranial magnetic stimulation electric field 221 provided by the transcranial magnetic stimulation three-dimensional coil device 10 is formed only by the first electric field of the first coil 11.

[0038] In addition, scenario 212 is, for example, a scenario in which only the second coil 12 of the transcranial magnetic stimulation 3D coil device 10 is excited to provide the second electric field. Since the first coil 11 and the third coil 13 are not excited, the transcranial magnetic stimulation electric field 222 provided by the transcranial magnetic stimulation 3D coil device 10 is formed only by the second electric field of the second coil 12.

[0039] The scenario 213 is, for example, a scenario in which the first coil 11 and the second coil 12 of the transcranial magnetic stimulation three-dimensional coil device 10 are simultaneously excited to provide the first electric field and the second electric field respectively. Since the third coil 13 is not excited, the transcranial magnetic stimulation electric field 223 provided by the transcranial magnetic stimulation three-dimensional coil device 10 is formed by the first electric field of the first coil 11 and the second electric field of the second coil 12.

[0040] Depend on Figure 2 It can be seen that by simultaneously exciting the first coil 11 and the second coil 12, the transcranial magnetic stimulation electric field 223 can be caused to rotate accordingly. In this case, the transcranial magnetic stimulation electric field 223 can be easily caused to rotate accordingly according to the designer's needs by simply adjusting the current intensity used to excite the first coil 11 and / or the second coil 12.

[0041] The scenario 214 is, for example, a scenario in which only the third coil 13 of the transcranial magnetic stimulation 3D coil device 10 is excited to provide the third electric field. Since the first coil 11 and the second coil 12 are not excited, the transcranial magnetic stimulation electric field 224 provided by the transcranial magnetic stimulation 3D coil device 10 is formed only by the third electric field of the third coil 13.

[0042] It can be seen from the transcranial magnetic stimulation electric fields 223 and 224 that if the third coil 13 is excited in addition to the first coil 11 and the second coil 12, the transcranial magnetic stimulation electric field 223 can be shifted left / right accordingly.

[0043] It can be seen that the transcranial magnetic stimulation electric field 223 can be easily adjusted by adjusting the current intensity used to stimulate the first coil 11, the second coil 12 and / or the third coil 13 to allow the transcranial magnetic stimulation electric field 223 to present corresponding rotation and displacement according to the needs of the designer, thereby allowing the formed transcranial magnetic stimulation electric field to present the state required by the designer. Therefore, the transcranial magnetic stimulation three-dimensional coil device 10 of the present invention can treat different brain areas of the patient through transcranial magnetic stimulation electric fields with different states without changing the coil.

[0044] Please refer to Figure 3A and Figure 3B , which are different views of a transcranial magnetic stimulation three-dimensional coil device according to an embodiment of the present invention. In this embodiment, the transcranial magnetic stimulation three-dimensional coil device 30 includes Figures 1A to 1DIn addition to the various components (such as the first coil 11 , the second coil 12 and the third coil 13 ) of the transcranial magnetic stimulation three-dimensional coil device 10 , it also includes a cylindrical housing 31 for accommodating the first coil 11 and the second coil 12 .

[0045] exist Figure 3A and Figure 3B In the embodiment, the cylindrical housing 31 has a bottom surface 311 and an opening 312 opposite to the bottom surface, wherein the bottom surface 311 is provided with ventilation holes 311 a - 311 d , and the opening 312 is used for being sleeved on the first coil 11 and the second coil 12 .

[0046] Please refer to Figure 4 , which is based on Figure 3A and Figure 3B A schematic diagram of the transcranial magnetic stimulation stereocoil apparatus is shown.

[0047] exist Figure 4 In the embodiment, assuming that the brain area 42 of the patient 41 is determined / diagnosed as requiring TMS treatment, relevant personnel (such as doctors, etc.) can plan the designated positions for setting one or more transcranial magnetic stimulation stereo coils 30 on the wearable device 43 (such as a helmet to be worn by the patient 41), for example Figure 4 The positions are numbered 1 to 4, but are not limited thereto.

[0048] Based on this, a plurality of transcranial magnetic stimulation three-dimensional coils 30 can be disposed at corresponding designated positions. Afterwards, each transcranial magnetic stimulation three-dimensional coil device 30 is excited to provide a transcranial magnetic stimulation electric field, and the transcranial magnetic stimulation electric field corresponding to each transcranial magnetic stimulation three-dimensional coil device 30 cooperates to form an integrated transcranial magnetic stimulation electric field corresponding to the transcranial magnetic stimulation three-dimensional coil device 44 (which includes a wearable device 43 and one or more transcranial magnetic stimulation three-dimensional coil devices 30).

[0049] Therefore, the transcranial magnetic stimulation three-dimensional coil device 44 of the present invention can treat different brain areas of the patient through integrated transcranial magnetic stimulation electric fields with different patterns without replacing the coil.

[0050] As can be seen from the above, the embodiment of the present invention provides a three-dimensional transcranial magnetic stimulation coil device with a novel structure, which includes three coils whose central axes are perpendicular to each other. In this case, the transcranial magnetic stimulation electric field can be easily adjusted by adjusting the current intensity used to excite the above coils to allow the transcranial magnetic stimulation electric field to present corresponding rotation and displacement according to the needs of the designer, thereby allowing the transcranial magnetic stimulation electric field provided by the three-dimensional transcranial magnetic stimulation coil device to present the state required by the designer. Therefore, the three-dimensional transcranial magnetic stimulation coil device of the present invention can treat different brain areas of the patient through transcranial magnetic stimulation electric fields with different states without changing the coil.

[0051] Please refer to Figure 5, which is a schematic diagram showing a transcranial magnetic stimulation three-dimensional coil device driven by a driving device according to an embodiment of the present invention.

[0052] exist Figure 5 In the embodiment, the driving device 50 can provide the first pulse current signal S1, the second pulse current signal S2 and the third pulse current signal S3 to the first coil 11, the second coil 12 and the third coil 13 respectively. In this case, the first coil 11, the second coil 12 and the third coil 13 can be excited respectively to generate corresponding magnetic fields according to Ampere's right-hand rule.

[0053] exist Figure 5 In the figure, it is assumed that the first magnetic field generated by the first coil 11 after being excited by the first pulse current signal S1 has a first magnetic field direction MD1, the second magnetic field generated by the second coil 12 after being excited by the second pulse current signal S2 has a second magnetic field direction MD2, and the third magnetic field generated by the third coil 13 after being excited by the third pulse current signal S3 has a third magnetic field direction MD3, but it is not limited to this.

[0054] For ease of understanding, the first magnetic field direction MD1, the second magnetic field direction MD2 and the third magnetic field direction MD3 can be understood as Figure 5 The +Y direction, +X direction, and +Z direction in the 3D space are shown, but are not limited thereto.

[0055] In an embodiment of the present invention, the driving device 50 can control the rotation direction and / or offset position of the magnetic field formed by the first, second and third magnetic fields as a whole by regulating the first pulse current signal S1, the second pulse current signal S2 and / or the third pulse current signal S3, which will be further explained below.

[0056] Please refer to Figure 6 , which is a flow chart of a driving method of a transcranial magnetic stimulation stereo coil device according to an embodiment of the present invention. The method of this embodiment can be Figure 5 The drive device 50 is executed, and the following is matched Figure 5 Description of components shown Figure 6 Details of each step.

[0057] In step S610 , the driving device 50 determines a first signal peak value and a second signal peak value corresponding to a designated rotating magnetic field direction, wherein the first signal peak value and the second signal peak value correspond to the first coil 11 and the second coil 12 , respectively.

[0058] In an embodiment of the present invention, the designated rotating magnetic field direction is, for example, the direction that the operator wants the N pole of the rotating magnetic field formed by the first and second magnetic fields to point to, but is not limited thereto.

[0059] In an embodiment of the present invention, the operator may, for example, select a desired one from among K preset candidate rotating magnetic field directions as the designated rotating magnetic field direction. Figure 6 In the example, the specified rotating magnetic field direction is Figure 6 One of the 20 (i.e., K is 20) candidate rotating magnetic field directions shown in the lower right corner, where the direction numbered 1 corresponds to the +X direction (i.e., corresponds to the second magnetic field direction MD2), and the direction numbered 6 corresponds to the +Y direction (i.e., corresponds to the first magnetic field direction MD1), but is not limited to this.

[0060] In an embodiment of the present invention, each candidate rotating magnetic field direction may have a corresponding first reference signal peak value and a second reference signal peak value, wherein the first reference signal peak value and the second reference signal peak value corresponding to the j-th candidate rotating magnetic field direction among the K candidate rotating magnetic field directions may be characterized as I 1,j (A) and I 2,j (A).

[0061] In the embodiment of the present invention, the first reference signal peak value and the second reference signal peak value of each candidate rotating magnetic field direction also correspond to the first coil 11 and the second coil 12 respectively.

[0062] exist Figure 6 In this scenario, the first reference signal peak values ​​and the second reference signal peak values ​​corresponding to the 20 candidate rotating magnetic field directions (numbered 1 to 20) may be as shown in Table 1 below.

[0063] serial number angle <![CDATA[Second reference signal peak value (I 2,j (A))]]> <![CDATA[First reference signal peak (I 1,j (A))]]> 1 0 7881.05 0.00 2 18 7447.59 2648.34 3 36 6218.15 5003.33 4 54 4303.05 6820.50 5 72 1930.86 7896.16 6 90 0.00 8148.75 7 108 -1930.86 7896.14 8 126 -4303.05 6820.50 9 144 -6218.15 5003.33 10 162 -7447.59 2648.34 11 180 -7881.05 0 12 198 -7447.59 -2648.34 13 216 -6218.15 -5003.33 14 234 -4303.05 -6820.50 15 252 -1930.86 -7896.16 16 270 0 -8148.75 17 288 1930.86 -7896.14 18 306 4303.05 -6820.50 19 324 6218.15 -5003.33 20 342 7447.59 -2648.34

[0064] Table 1

[0065] Based on this, in one embodiment, the operator can, for example, select a desired one from the 20 candidate rotating magnetic field directions in Table 1 as the above-mentioned designated rotating magnetic field direction, and use the corresponding first reference signal peak value and second reference signal peak value (in amperes (A)) as the first signal peak value and second signal peak value in step S610.

[0066] For example, assuming that the operator wants the N pole of the rotating magnetic field formed by the first and second magnetic fields to point to the direction corresponding to number 4 (that is, to use the direction of number 4 as the above-mentioned designated rotating magnetic field direction), the driving device 50 can, for example, use 6820.50 and 4303.05 as the first signal peak and second signal peak considered in step S610 respectively.

[0067] To give another example, assuming that the operator wants the N pole of the rotating magnetic field formed by the first and second magnetic fields to point to the direction corresponding to number 19 (that is, to use the direction of number 19 as the above-mentioned designated rotating magnetic field direction), the driving device 50 can, for example, use -5003.33 and 6218.15 as the first signal peak and the second signal peak considered in step S610, respectively.

[0068] In one embodiment, the contents of Table 1 may be drawn as follows: Figure 7 The waveform shown. Figure 7 It can be seen that the change in the peak value of the first reference signal corresponding to different direction numbers has a trend corresponding to the first sine wave (such as a sine wave), and the change in the peak value of the second reference signal corresponding to different direction numbers has a trend corresponding to the second sine wave (such as a cosine wave).

[0069] In some embodiments, -1≤I 1,j (A) / I 1,max (A)≤1,-1≤I 2,j (A) / I 2,max (A)≤1, where I 1,max (A) is the maximum value among the first reference signal peaks corresponding to each candidate rotating magnetic field direction, I 2,max (A) is the maximum value among the second reference signal peaks corresponding to the candidate rotating magnetic field directions. In addition, in some embodiments, -1.414≤I 2,j (A) / I 2,max (A)+I 1,j (A) / I 1,max (A)≤1.414.

[0070] In the scenario in Table 1, 1,max (A) is 8148.75, while I 2,max (A) is 7881.05. Based on this, Table 1 can be further extended to the following Table 2.

[0071]

[0072] Table 2

[0073] In addition, Figure 7 In the scenario, the third (reference) signal peak value corresponding to the third coil 13 can be designed to be a constant value (such as -8000 amperes as shown) to avoid causing the rotating magnetic field formed by the first and second magnetic fields to be offset, but it is not limited to this.

[0074] Please refer again Figure 6After determining the required first and second signal peak values, the driving device 50 may continue to perform step S620 to provide a first pulse current signal S1 having a first signal peak value to the first coil 11, and perform step S630 to provide a second pulse current signal S2 having a second signal peak value to the second coil 12. In an embodiment of the present invention, the first pulse current signal S1 excites the first coil 11 to provide a first magnetic field, and the second pulse current signal S2 excites the second coil 12 to provide a second magnetic field, and the first magnetic field and the second magnetic field form a rotating magnetic field having a specified rotating magnetic field direction.

[0075] In other embodiments, the order of steps S620 and S630 may be reversed or performed simultaneously, but is not limited thereto.

[0076] In different embodiments, the first pulse current signal S1 and the second pulse current signal S2 may be single-phase pulse current signals or dual-phase pulse current signals, respectively.

[0077] In some embodiments, the first current change rate of the first pulse current signal S1 is, for example, 13.67A / μs to 136.67A / μs. In addition, the second current change rate of the second pulse current signal S2 is, for example, 12.89A / μs to 128.93A / μs, but is not limited thereto.

[0078] Please refer to Figure 8 , which is a schematic diagram of the first and second pulse current signals shown in Table 1. Figure 8 In each of the waveform diagrams 801-820 shown, the corresponding first and second pulse current signals are, for example, biphasic pulse current signals (i.e., pulse current signals including a positive half cycle and a negative half cycle), and the waveform diagrams 801-820 may correspond to the 20 candidate rotating magnetic field directions in Table 1 in sequence. In other embodiments, the first and second pulse current signals may also be single-phase pulse current signals (i.e., pulse current signals including only a positive half cycle or a negative half cycle).

[0079] In each of the waveform diagrams 801 to 820 , the waveform corresponding to the first pulse current signal S1 is shown as a dotted line, and the waveform corresponding to the second pulse current signal S2 is shown as a solid line.

[0080] For example, in Table 1, the first reference signal peak value and the second reference signal peak value corresponding to the candidate rotating magnetic field direction numbered 1 are 0.00 and 7881.05 respectively. Figure 8In the waveform diagram 801 (which corresponds to the candidate rotating magnetic field direction numbered 1), the first reference signal peak value of the first pulse current signal 801a is, for example, 0.00, and the second reference signal peak value of the second pulse current signal 801b is, for example, 7881.05. In other words, if the operator wants the N pole of the rotating magnetic field formed by the first and second magnetic fields to point to the direction corresponding to numbered 1 (i.e., the direction numbered 1 is used as the above-mentioned designated rotating magnetic field direction), the driving device 50 may, for example, provide the first pulse current signal 801a to the first coil 11 in step S620, and provide the second pulse current signal 801b to the first coil 12 in step S630.

[0081] For another example, in Table 1, the first reference signal peak value and the second reference signal peak value corresponding to the candidate rotating magnetic field direction numbered 2 are 2648.34 and 7447.59 respectively. Figure 8 In the waveform diagram 802 (which corresponds to the candidate rotating magnetic field direction numbered 2), the first reference signal peak value of the first pulse current signal 802a is, for example, 2648.34, and the second reference signal peak value of the second pulse current signal 802b is, for example, 7447.59. In other words, if the operator wants the N pole of the rotating magnetic field formed by the first and second magnetic fields to point to the direction corresponding to numbered 2 (i.e., the direction numbered 2 is used as the above-mentioned designated rotating magnetic field direction), the driving device 50 may, for example, provide the first pulse current signal 802a to the first coil 11 in step S620, and provide the second pulse current signal 802b to the first coil 12 in step S630.

[0082] For ease of understanding, the following is supplemented by Fig. 9 For further explanation.

[0083] Please refer to Fig. 9 , which is an application scenario diagram according to an embodiment of the present invention. Fig. 9 In the present invention, the transcranial magnetic stimulation stereo coil device 10 can be set on a model 900 for simulating a human head, wherein the model 900 is, for example, a homogeneous sphere with a radius of 8.5 cm and an isotropic conductivity of 0.33 Sm. In addition, the distance between the cortical surface of the model 900 and the gray matter-white matter interface is 1.5 cm to 2 cm.

[0084] exist Fig. 9 In the embodiment, it is assumed that the direction numbered 4 in Table 1 is selected as the designated rotating magnetic field direction in step S610. Accordingly, the driving device 50 may be configured to Figure 8The first pulse current signal S1 and the second pulse current signal S2 for driving the first coil 11 and the second coil 12 are determined based on the waveform diagram 804 in FIG. 8 and the related information corresponding to number 4 in Table 1.

[0085] exist Fig. 9 In the embodiment, the first coil 11 can provide a first magnetic field having a first magnetic field direction MD1 after being excited by the first pulse current signal S1, and the first magnetic field can correspondingly generate a first electric field having a first electric field direction ED1 (which is orthogonal to the first magnetic field direction MD1) in the model 900. In addition, the second coil 12 can provide a second magnetic field having a second magnetic field direction MD2 after being excited by the second pulse current signal S2, and the second magnetic field can correspondingly generate a second electric field having a second electric field direction ED2 (which is orthogonal to the second magnetic field direction MD2) in the model 900.

[0086] In this case, the first electric field and the second electric field may be superimposed in the model 900 to form a superimposed electric field with an integrated electric field direction RED.

[0087] From another point of view, the first magnetic field and the second magnetic field can be superimposed to form a rotating magnetic field having a specified rotating magnetic field direction RMD (for example, the direction numbered 4 in Table 1), and this rotating magnetic field can correspondingly form a superimposed electric field having an integrated electric field direction RED (which is orthogonal to the specified rotating magnetic field direction RMD) in model 900.

[0088] As can be seen from the above, through the method proposed by the present invention, the operator can adjust the superimposed electric field formed by the first coil 11 and the second coil 12 in the model 900 by adjusting the first and second pulse current signals without moving the position of the transcranial magnetic stimulation three-dimensional coil device 10. Therefore, when the transcranial magnetic stimulation three-dimensional coil device 10 is set on the patient's head, an electric field with a specific direction can be applied more flexibly to the brain area to be treated, thereby improving the convenience of treatment.

[0089] In some embodiments, in addition to driving the first coil 11 and the second coil 12 in the above manner, the method of the present invention can further drive the third coil 13 in a specific manner, so that the first coil 11, the second coil 12, and the third coil 13 can generate a magnetic field / electric field with a desired appearance / direction after being driven.

[0090] Please refer again Figure 6 In one embodiment, the driving device 50 may further execute step S640 to determine a third signal peak value, wherein the third signal peak value corresponds to the third coil 13 .

[0091] Thereafter, in step S650 , the driving device 50 provides a third pulse current signal S3 having a third signal peak value to the third coil 13 .

[0092] In an embodiment of the present invention, the third pulse current signal S3 may be a single-phase pulse current signal or a bi-phase pulse current signal. In addition, the third current change rate of the third pulse current signal S3 is, for example, 12.53A / μs to 125.33A / μs, but is not limited thereto.

[0093] To make the above concepts easier to understand, the following is supplemented by Fig.10 , Fig.11 For further explanation.

[0094] Please refer to Fig.10 , which is an application scenario diagram shown according to an embodiment of the present invention.

[0095] exist Fig.10 In each scenario, it is assumed that the driving device 50 drives the third coil 13 with a third pulse current signal S3 having a third signal peak value while driving the first coil 11 and the second coil 12. In this embodiment, it is assumed that the third coil 13 is driven to provide a third magnetic field corresponding to the third magnetic field direction MD3 in the +Z direction. In this case, the third magnetic field will correspondingly affect the rotating magnetic field formed by the first and second magnetic fields. In other words, the third electric field induced by the third magnetic field will also affect the superimposed electric field formed by the first and second electric fields.

[0096] For example, in Fig.10 In scenario (a), assuming that the specified rotating magnetic field direction is the direction numbered 4 in Table 1, the driving device 50 can, for example, drive the first coil 11 and the second coil 12 according to previous teachings to generate a rotating magnetic field having a specified rotating magnetic field direction RMD (for example, the direction numbered 4 in Table 1), and this rotating magnetic field can correspondingly form a superimposed electric field having an integrated electric field direction RED.

[0097] In addition, when the third coil 13 is also driven, the third magnetic field formed therein will cause the rotating magnetic field formed by the first and second magnetic fields to shift toward the specified magnetic field offset position, and the shifted rotating magnetic field (which can be understood as a superimposed magnetic field formed by the superposition of the first, second, and third magnetic fields) can correspondingly induce an electric field as shown in the electric field diagram 1010.

[0098] In the electric field diagram 1010, the electric field shown can be understood as the state of the superposition of the first and second electric fields after being affected by the third electric field, and can also be understood as a specific superposition electric field formed by the superposition of the first, second and third electric fields. It can be seen from the electric field diagram 1010 that the specific superposition electric field shown is offset toward a specific electric field position 1010a.

[0099] To take another example, in Fig.10In scenario (b), assuming that the specified rotating magnetic field direction is the direction numbered 14 in Table 1, the driving device 50 can, for example, drive the first coil 11 and the second coil 12 according to previous teachings to generate a rotating magnetic field having a specified rotating magnetic field direction RMD (for example, the direction numbered 14 in Table 1), and this rotating magnetic field can correspondingly form a superimposed electric field having an integrated electric field direction RED.

[0100] In addition, when the third coil 13 is also driven, the third magnetic field formed therein will cause the rotating magnetic field formed by the first and second magnetic fields to shift toward the specified magnetic field offset position, and the shifted rotating magnetic field (which can be understood as a superimposed magnetic field formed by the superposition of the first, second, and third magnetic fields) can correspondingly induce an electric field as shown in the electric field diagram 1020.

[0101] In the electric field diagram 1020, the electric field shown can be understood as the state of the superposition of the first and second electric fields after being affected by the third electric field, and can also be understood as a specific superposition electric field formed by the superposition of the first, second, and third electric fields. It can be seen from the electric field diagram 1020 that the specific superposition electric field shown is offset toward the specific electric field position 1020a.

[0102] To take another example, in Fig.10 In scenario (c), assuming that the specified rotating magnetic field direction is the direction numbered 16 in Table 1, the driving device 50 can, for example, drive the first coil 11 and the second coil 12 according to previous teachings to generate a rotating magnetic field having a specified rotating magnetic field direction RMD (for example, the direction numbered 16 in Table 1), and this rotating magnetic field can correspondingly form a superimposed electric field having an integrated electric field direction RED.

[0103] In addition, when the third coil 13 is also driven, the third magnetic field formed therein will cause the rotating magnetic field formed by the first and second magnetic fields to shift toward the specified magnetic field offset position, and the shifted rotating magnetic field (which can be understood as a superimposed magnetic field formed by the superposition of the first, second, and third magnetic fields) can correspondingly induce an electric field as shown in the electric field diagram 1030.

[0104] In the electric field diagram 1030, the electric field shown can be understood as the state of the superposition of the first and second electric fields after being affected by the third electric field, and can also be understood as a specific superposition electric field formed by the superposition of the first, second, and third electric fields. It can be seen from the electric field diagram 1030 that the specific superposition electric field shown is offset toward the specific electric field position 1030a.

[0105] Please refer to Fig.11 , which is an application scenario diagram shown according to an embodiment of the present invention.

[0106] exist Fig.11In each scenario, it is assumed that the driving device 50 drives the first coil 11 and the second coil 12 while driving the third coil 13 with a third pulse current signal S3 having a third signal peak value. Fig.10 The difference is that Fig.11 It is assumed that the third coil 13 is driven to provide a third magnetic field corresponding to the third magnetic field direction MD3 in the -Z direction. In this case, the third magnetic field will accordingly affect the rotating magnetic field formed by the first and second magnetic fields. In other words, the third electric field induced by the third magnetic field will also affect the superimposed electric field formed by the first and second electric fields.

[0107] For example, in Fig.11 In scenario (a), assuming that the specified rotating magnetic field direction is the direction numbered 4 in Table 1, the driving device 50 can, for example, drive the first coil 11 and the second coil 12 according to previous teachings to generate a rotating magnetic field having a specified rotating magnetic field direction RMD (for example, the direction numbered 4 in Table 1), and this rotating magnetic field can correspondingly form a superimposed electric field having an integrated electric field direction RED.

[0108] In addition, when the third coil 13 is also driven, the third magnetic field formed therein will cause the rotating magnetic field formed by the first and second magnetic fields to shift toward the specified magnetic field offset position, and the shifted rotating magnetic field (which can be understood as a superimposed magnetic field formed by the superposition of the first, second, and third magnetic fields) can correspondingly induce an electric field as shown in the electric field diagram 1110.

[0109] In the electric field diagram 1110, the electric field shown can be understood as the state of the superposition of the first and second electric fields after being affected by the third electric field, and can also be understood as a specific superposition electric field formed by the superposition of the first, second and third electric fields. It can be seen from the electric field diagram 1110 that the specific superposition electric field shown is offset toward the specific electric field position 1110a.

[0110] Depend on Fig.10 Scenario (a) and Fig.11 As can be seen from scenario (a), the electric field can be shifted toward the opposite position by adjusting the third magnetic field direction MD3 (eg, +Z or −Z direction) of the third magnetic field.

[0111] To take another example, in Fig.11 In scenario (b), assuming that the specified rotating magnetic field direction is the direction numbered 9 in Table 1, the driving device 50 can, for example, drive the first coil 11 and the second coil 12 according to previous teachings to generate a rotating magnetic field having a specified rotating magnetic field direction RMD (for example, the direction numbered 9 in Table 1), and this rotating magnetic field can correspondingly form a superimposed electric field having an integrated electric field direction RED.

[0112] In addition, when the third coil 13 is also driven, the third magnetic field formed therein will cause the rotating magnetic field formed by the first and second magnetic fields to shift toward the specified magnetic field offset position, and the shifted rotating magnetic field (which can be understood as a superimposed magnetic field formed by the superposition of the first, second, and third magnetic fields) can correspondingly induce an electric field as shown in the electric field diagram 1120.

[0113] In the electric field diagram 1120, the electric field shown can be understood as the state of the superposition of the first and second electric fields after being affected by the third electric field, and can also be understood as a specific superposition electric field formed by the superposition of the first, second, and third electric fields. It can be seen from the electric field diagram 1120 that the specific superposition electric field shown is offset toward the specific electric field position 1120a.

[0114] To take another example, in Fig.11 In scenario (c), assuming that the specified rotating magnetic field direction is the direction numbered 11 in Table 1, the driving device 50 can, for example, drive the first coil 11 and the second coil 12 according to previous teachings to generate a rotating magnetic field having a specified rotating magnetic field direction RMD (for example, the direction numbered 11 in Table 1), and this rotating magnetic field can correspondingly form a superimposed electric field having an integrated electric field direction RED.

[0115] In addition, when the third coil 13 is also driven, the third magnetic field formed therein will cause the rotating magnetic field formed by the first and second magnetic fields to shift toward the specified magnetic field offset position, and the shifted rotating magnetic field (which can be understood as a superimposed magnetic field formed by the superposition of the first, second, and third magnetic fields) can correspondingly induce an electric field as shown in the electric field diagram 1130.

[0116] In the electric field diagram 1130, the electric field shown can be understood as the state of the superposition of the first and second electric fields after being affected by the third electric field, and can also be understood as a specific superposition electric field formed by the superposition of the first, second, and third electric fields. It can be seen from the electric field diagram 1130 that the specific superposition electric field shown is offset toward the specific electric field position 1130a.

[0117] In addition, Fig.11 In scenario (d), assuming that the specified rotating magnetic field direction is the direction numbered 16 in Table 1, the driving device 50 can, for example, drive the first coil 11 and the second coil 12 according to previous teachings to generate a rotating magnetic field having a specified rotating magnetic field direction RMD (for example, the direction numbered 16 in Table 1), and this rotating magnetic field can correspondingly form a superimposed electric field having an integrated electric field direction RED.

[0118] In addition, when the third coil 13 is also driven, the third magnetic field formed by it will cause the rotating magnetic field formed by the first and second magnetic fields to shift toward the specified magnetic field offset position, and the shifted rotating magnetic field (which can be understood as a superimposed magnetic field formed by the superposition of the first, second, and third magnetic fields) can correspondingly induce an electric field as shown in the electric field diagram 1140.

[0119] In the electric field diagram 1140, the electric field shown can be understood as the state of the superposition of the first and second electric fields after being affected by the third electric field, and can also be understood as a specific superposition electric field formed by the superposition of the first, second, and third electric fields. It can be seen from the electric field diagram 1140 that the specific superposition electric field shown is offset toward the specific electric field position 1140a.

[0120] Depend on Fig.10 Scenario (c) and Fig.11 As can be seen from scenario (d), the electric field can be shifted toward the opposite position by adjusting the third magnetic field direction MD3 (eg, +Z or −Z direction) of the third magnetic field.

[0121] As can be seen from the above, through the method proposed by the present invention, the operator can adjust the specific superimposed electric field formed by the first coil 11, the second coil 12 and the third coil (for example, shift in a certain direction) by adjusting the first, second and third pulse current signals without moving the position of the transcranial magnetic stimulation three-dimensional coil device 10. Therefore, when the transcranial magnetic stimulation three-dimensional coil device 10 is set on the patient's head, an electric field with a specific direction can be applied more flexibly to the brain area to be treated, thereby improving the convenience of treatment.

[0122] In summary, the driving method provided by the embodiment of the present invention can adjust the field type / direction / offset position of the superimposed electric field / magnetic field by adjusting the pulse current signal corresponding to each coil without moving the position of the transcranial magnetic stimulation three-dimensional coil device. Therefore, when the transcranial magnetic stimulation three-dimensional coil device is set on the patient's head, an electric field with a specific direction can be applied more flexibly to the brain area to be treated, thereby improving the convenience of treatment.

[0123] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A driving method for a transcranial magnetic stimulation three-dimensional coil device, suitable for driving a device, wherein the transcranial magnetic stimulation three-dimensional coil device comprises a plurality of coils, and the central axes of the coils are perpendicular to each other, characterized in that: The method comprises: determining a first signal peak value and a second signal peak value corresponding to a specified rotating magnetic field direction, wherein the first signal peak value and the second signal peak value correspond to a first coil and a second coil of the plurality of coils, respectively; Providing a first pulse current signal having the first signal peak value to the first coil, wherein the first pulse current signal excites the first coil to provide a first magnetic field; A second pulse current signal having the second signal peak value is provided to the second coil, wherein the second pulse current signal excites the second coil to provide a second magnetic field, and the first magnetic field and the second magnetic field form a rotating magnetic field having the specified rotating magnetic field direction.

2. The driving method according to claim 1, further comprising: determining a third signal peak, wherein the third signal peak corresponds to a third coil among the plurality of coils; A third pulse current signal having the third signal peak is provided to the third coil, wherein the third pulse current signal excites the third coil to provide a third magnetic field, and the third magnetic field shifts the rotating magnetic field toward a designated magnetic field offset position. 3 . The driving method according to claim 2 , wherein the third pulse current signal is a single-phase pulse current signal or a bi-phase pulse current signal. 4 . The driving method according to claim 2 , wherein a third current change rate of the third pulse current signal is 12.53 amperes per microsecond to 125.33 amperes per microsecond. 5 . The driving method according to claim 1 , wherein the first pulse current signal and the second pulse current signal are single-phase pulse current signals or dual-phase pulse current signals, respectively. 6 . The driving method according to claim 1 , wherein a first current change rate of the first pulse current signal is 13.67 amperes per microsecond to 136.67 amperes per microsecond. 7 . The driving method according to claim 1 , wherein a second current change rate of the second pulse current signal is 12.89 amperes / microseconds to 128.93 amperes / microseconds.

8. The driving method according to claim 1, wherein the designated rotating magnetic field direction is selected from K candidate rotating magnetic field directions, and each of the candidate rotating magnetic field directions has a corresponding first reference signal peak value and a second reference signal peak value, wherein K is a positive integer, and the first reference signal peak value and the second reference signal peak value corresponding to the j-th candidate rotating magnetic field direction among the K candidate rotating magnetic field directions are characterized as I 1,j (A) and I 2,j (A).

9. The driving method according to claim 8, wherein -1≤I 1,j (A) / I 1,max (A)≤1,-1≤I 2,j (A) / I 2,max (A)≤1, where I 1,max (A) is the maximum value among the first reference signal peaks corresponding to the candidate rotating magnetic field directions, I 2,max (A) is the maximum value among the second reference signal peaks corresponding to the candidate rotating magnetic field directions.

10. The driving method according to claim 8, wherein -1.414≤I 2,j (A) / I 2,max (A)+I 1,j (A) / I 1,max (A)≤1.414, where I 1,max (A) is the maximum value among the first reference signal peaks corresponding to the candidate rotating magnetic field directions, I 2,max (A) is the maximum value among the second reference signal peaks corresponding to the candidate rotating magnetic field directions.

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