Preparation process and application of anti-skin aging serine

Abstract

The invention belongs to the technical field of serine preparation, and particularly relates to a skin aging resistant serine preparation technology and application thereof.The skin aging resistant serine preparation technology comprises a stirring tank, a tank cover is arranged at the top of the stirring tank, a driving shaft is inserted into the tank cover in a penetrating mode, a motor is in transmission connection with the top end of the driving shaft, and two stirring devices are arranged on the driving shaft; the stirring device is composed of a plurality of stirring assemblies. Through the arrangement of the sieve plate, in the stirring process, when a lower-layer medium and an upper-layer medium make contact with the sieve plate, sieve holes in the sieve plate can cut the upper-layer medium and the lower-layer medium, so that the upper-layer medium and the lower-layer medium can be cut into smaller volumes and fused better and faster; in addition, the inclined sieve plate can convey the upper-layer medium and the lower-layer medium downwards, so that the floating upper-layer medium can be better fused into the lower-layer medium, and the fusion efficiency of the upper-layer medium and the lower-layer medium is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of serine preparation, and in particular relates to a preparation process of serine for resisting skin aging and application thereof. Background Art

[0002] Serine is an important material for skin care products. It is suitable for dry skin or for use in dry environments. It can form a protective film on the skin surface to prevent moisture loss.

[0003] In the preparation of existing serine, the raw materials need to be added into a stirring tank for mixing to obtain the desired product. However, in the process of mixing the raw materials, different raw materials are difficult to mix. In addition, since the stirring shaft in the existing stirring tank generally only has a simple stirring function, the mixing and emulsification efficiency of the raw materials is low when the raw materials are stirred and mixed.

[0004] Therefore, it is necessary to invent a serine preparation process for resisting skin aging and its application to solve the above problems. Summary of the invention

[0005] In view of the above problems, the present invention provides a preparation process of serine for resisting skin aging and its application to solve the problems raised in the above background technology.

[0006] To achieve the above object, the present invention provides the following technical solutions: a process for preparing serine for resisting skin aging, wherein a device for preparing serine comprises a stirring tank, a tank cover is arranged on the top of the stirring tank, a driving shaft is inserted through the tank cover, a motor is connected to the top of the driving shaft, two groups of stirring devices are arranged on the driving shaft, the stirring device is composed of a plurality of stirring components, the stirring components comprise a sieve plate, a sleeve, a first rotating shaft, a first auger blade, a pressing plate, a pressing spring and a driving component, and a mixing component is arranged between two adjacent sieve plates; The specific preparation process of the serine for resisting skin aging comprises the following steps: Step 1: Place methanol in a stirring tank, add cystine and chloroform in an ice-salt bath, and stir to react for 12 hours. When the reaction is complete, concentrate to 1 / 2 of the original volume, stand for crystallization, and collect and dry. Step 2: Cysteine ​​dimethyl ester dihydrochloride was chlorinated in chloroform medium, introduced with chlorine gas, and chlorinated at low temperature and normal pressure for 48 hours. After the reaction was completed, a small amount of ether was added to the reaction solution, and dry air was blown in to drive away excess halogen and HCL, and B-chloroalanine methyl ester hydrochloride was precipitated at room temperature; Step 3: Remove the ester group of the prepared B-chloroalanine methyl ester hydrochloride in 2NNaOH, adjust the pH to 6.5 with dilute HCL, desalt on a column, and concentrate and crystallize to obtain L-serine.

[0007] Furthermore, the sieve plate is fixedly connected to the surface of the drive shaft, the sleeve is in an inclined state, and the sleeve is fixedly connected to the side of the sieve plate away from the drive shaft, the first rotating shaft is located at the axis center of the sleeve, the top end of the first rotating shaft is rotatably connected to the top inner wall of the sleeve, the first auger blade is fixedly connected to the surface of the first rotating shaft, the pressure plate is rotatably sleeved on the first rotating shaft near the top, the two ends of the clamping spring are respectively fixedly connected to the upward side of the pressure plate and the top inner wall of the sleeve, and a plurality of discharge holes are opened through the surface of the sleeve near the top.

[0008] Furthermore, the driving assembly includes an annular track, a protective ring and a plurality of first bevel gears. The annular track is fixedly connected to the side wall of the mixing tank. An annular groove is provided on the inner side of the annular track. Teeth are evenly arranged on the bottom groove wall of the annular groove. The protective ring is rotatably installed on the inner side of the opening of the annular groove. The plurality of first bevel gears are fixedly sleeved on the bottom ends of a plurality of first rotating shafts one by one. The bottom ends of the first rotating shafts are rotatably inserted into the protective ring. The first bevel gears are located in the annular groove, and the first bevel gears are meshed with the teeth on the bottom inner wall of the annular groove.

[0009] Furthermore, the mixing assembly includes a second rotating shaft, a plurality of stirring rods and a second bevel gear. The second rotating shaft is arranged at an angle, the top end of the second rotating shaft is rotatably connected to the surface of the driving shaft, the bottom end of the second rotating shaft is rotatably inserted into the protective ring, the second bevel gear is fixedly sleeved on the bottom end of the second rotating shaft, and the second bevel gear is meshed with teeth on the inner wall of the bottom of the annular groove, and the plurality of stirring rods are evenly and vertically fixedly connected to the surface of the second rotating shaft.

[0010] Furthermore, a second auger blade is arranged between the two groups of the stirring devices, the second auger blade is fixedly connected to the driving shaft, the diameter of the second auger blade gradually increases from top to bottom, and the conveying direction of the second auger blade to the raw material is opposite to the conveying direction of the screen plate to the raw material.

[0011] Furthermore, the diameter of the pressure plate matches the inner diameter of the sleeve, and the edge of the pressure plate protrudes upward, and the height of the upward protruding portion of the pressure plate edge is greater than the opening height of the discharge hole, the initial height of the pressure plate is lower than the height of the discharge hole, and the top edge of the upward protruding portion of the pressure plate is always higher than the top inner wall of the discharge hole.

[0012] Furthermore, the sieve plate is arranged at an angle, the sieve plate and the plurality of stirring rods on the second rotating shaft are located in the same height area, and the sieve plate can transport the raw materials downward.

[0013] Furthermore, two feed pipes are connected to the top of the tank cover, and a discharge pipe is connected to the side of the stirring tank near the bottom.

[0014] Furthermore, the diameter of the first auger blade matches the inner diameter of the sleeve, and the length of the first auger blade is the same as the distance from the bottom of the pressure plate to the bottom end of the sleeve in the initial state.

[0015] The anti-skin aging serine provided by the invention is applied to emulsion, water, cream, essence, facial mask, soap, shampoo, conditioner, shower gel and cleanser in cosmetics.

[0016] Technical effects and advantages of the present invention: 1. The present invention is provided with a sieve plate. During the stirring process, when the lower medium and the upper medium contact the sieve plate, the sieve holes on the sieve plate can cut the upper medium and the lower medium, so that the upper medium and the lower medium can be cut into smaller volumes, thereby facilitating better and faster fusion of the upper medium and the lower medium. In addition, the inclined sieve plate can also transport the upper medium and the lower medium downward, so that the floating upper medium can be better integrated into the lower medium, thereby improving the fusion efficiency of the upper medium and the lower medium; 2. The present invention is provided with a first auger blade. During the rotation of the first rotating shaft, the first auger blade can rotate in the sleeve, so as to transport the upper medium and the lower medium upward along the sleeve. Before the upper medium and the lower medium are discharged from the sleeve through the discharge hole of the sleeve, the compression spring can always apply pressure to the upper medium and the lower medium through the pressure plate, thereby making the upper medium and the lower medium merge faster under the action of pressure, thereby improving the emulsification efficiency of the upper medium and the lower medium; 3. The present invention is provided with a mixing assembly. During the rotation of the driving shaft, the stirring rod on the second rotating shaft can stir and mix the upper medium and the lower medium after being divided by the sieve plate, and then cooperate with the sleeve, the sieve plate, and the second rotating shaft to stir the upper medium and the lower medium in the stirring tank, thereby improving the mixing efficiency and mixing effect of the lower medium and the upper medium; 4. By providing a second auger blade, during the rotation of the drive shaft, the second auger blade can transport the emulsion in the stirring tank upward, thereby cooperating with the sieve plate to transport the emulsion downward, so that the emulsion in the stirring tank can flow up and down from the side wall of the stirring tank to the middle of the stirring tank and form a circulation, thereby improving the emulsification effect and emulsification efficiency of the emulsion in the stirring tank. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0018] Figure 2 It is a three-dimensional schematic diagram of the stirring tank and its internal structure in the present invention.

[0019] Figure 3 It is a three-dimensional schematic diagram of all the internal structures of the stirring tank in the present invention.

[0020] Figure 4 It is a three-dimensional cross-sectional view of the sleeve in the present invention.

[0021] Figure 5 It is a three-dimensional schematic diagram of the pressure plate and the compression spring in the present invention.

[0022] Figure 6 It is a three-dimensional schematic diagram of the second rotating shaft, the stirring rod and the second bevel gear in the present invention.

[0023] Figure 7 It is a three-dimensional cross-sectional view of the stirring tank in the present invention.

[0024] In the figure: 1. mixing tank; 2. tank cover; 3. driving shaft; 4. motor; 5. sieve plate; 6. sleeve; 7. first rotating shaft; 8. first auger blade; 9. pressure plate; 10. compression spring; 11. discharge hole; 12. annular track; 13. protective ring; 14. first bevel gear; 15. second rotating shaft; 16. stirring rod; 17. second bevel gear; 18. second auger blade; 19. feed pipe; 20. discharge pipe. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solution and advantages of the embodiments of the present invention more clear, the technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments.

[0026] The present invention provides Figures 1 to 7 A serine preparation process for resisting skin aging is shown, and a device for preparing serine includes a stirring tank 1, a tank cover 2 is arranged on the top of the stirring tank 1, a driving shaft 3 is inserted through the tank cover 2, and a motor 4 is connected to the top of the driving shaft 3. Two groups of stirring devices are arranged on the driving shaft 3, and the stirring device is composed of a plurality of stirring components. The stirring components include a sieve plate 5, a sleeve 6, a first rotating shaft 7, a first auger blade 8, a pressing plate 9, a pressing spring 10 and a driving component, and a mixing component is arranged between two adjacent sieve plates 5; The specific preparation process of the serine for resisting skin aging comprises the following steps: Step 1: put methanol in a stirring tank 1, add cystine and chloroform in an ice-salt bath, and stir to react for 12 hours. When the reaction is complete, concentrate to 1 / 2 of the original volume, stand for crystallization, and collect and dry; Step 2: Cysteine ​​dimethyl ester dihydrochloride was chlorinated in chloroform medium, introduced with chlorine gas, and chlorinated at low temperature and normal pressure for 48 hours. After the reaction was completed, a small amount of ether was added to the reaction solution, and dry air was blown in to drive away excess halogen and HCL, and B-chloroalanine methyl ester hydrochloride was precipitated at room temperature; Step 3: Remove the ester group of the prepared B-chloroalanine methyl ester hydrochloride in 2NNaOH, adjust the pH to 6.5 with dilute HCL, desalt on a column, and concentrate and crystallize to obtain L-serine.

[0027] like Figure 1-Figure 5 As shown, the sieve plate 5 is fixedly connected to the surface of the drive shaft 3, the sleeve 6 is in an inclined state, and the sleeve 6 is fixedly connected to the side of the sieve plate 5 away from the drive shaft 3, the first rotating shaft 7 is located at the axis of the sleeve 6, the top of the first rotating shaft 7 is rotatably connected to the top inner wall of the sleeve 6, the first auger blade 8 is fixedly connected to the surface of the first rotating shaft 7, the pressure plate 9 is rotatably sleeved on the position near the top of the first rotating shaft 7, the two ends of the compression spring 10 are respectively fixedly connected to the upward side of the pressure plate 9 and the top inner wall of the sleeve 6, a plurality of discharge holes 11 are opened through the surface of the sleeve 6 near the top, two feed pipes 19 are connected to the top of the tank cover 2, and a discharge pipe 20 is connected to the side of the mixing tank 1 near the bottom, the diameter of the first auger blade 8 matches the inner diameter of the sleeve 6, and the length of the first auger blade 8 is the same as the distance from the bottom of the pressure plate 9 to the bottom of the sleeve 6 in the initial state.

[0028] like Figures 2 to 7 As shown, the driving assembly includes an annular track 12, a protective ring 13 and a plurality of first bevel gears 14, the annular track 12 is fixedly connected to the side wall of the mixing tank 1, an annular groove is provided on the inner side of the annular track 12, teeth are evenly arranged on the bottom groove wall of the annular groove, the protective ring 13 is rotatably installed at the inner side of the opening of the annular groove, a plurality of the first bevel gears 14 are fixedly sleeved on the bottom ends of a plurality of first rotating shafts 7 one by one, the bottom ends of the first rotating shafts 7 are rotatably inserted into the protective ring 13, the first bevel gear 14 is located in the annular groove, and the first bevel gear 14 is meshed with the teeth on the bottom inner wall of the annular groove; After the lower layer medium is added into the stirring tank 1 through one of the feed pipes 19 on the top of the tank cover 2, the motor 4 is started. At this time, the motor 4 can drive the sieve plate 5 and the sleeve 6 to move around the drive shaft 3 through the drive shaft 3, so as to stir the lower layer medium. Then, the upper layer medium is slowly added into the lower layer medium through another feed pipe 19 to form colostrum, and then the rotation speed of the drive shaft 3 is reduced to reduce the stirring speed. During the stirring process, as the sieve plate 5 moves, when the lower layer medium and the upper layer medium contact the sieve plate 5, the sieve holes on the sieve plate 5 can cut the upper layer medium and the lower layer medium, so that the upper layer medium and the lower layer medium can be cut into smaller volumes, thereby facilitating better and faster fusion of the upper layer medium and the lower layer medium. In addition, the inclined sieve plate 5 can also transport the upper medium and the lower medium downward, so that the floating upper medium can be better integrated into the lower medium, thereby improving the fusion efficiency of the upper medium and the lower medium; At the same time, with the movement of the sleeve 6, the first rotating shaft 7 can drive the protective ring 13 to perform annular movement under the action of the sleeve 6. During this process, the first bevel gear 14 at the bottom of the first rotating shaft 7 can roll in accordance with the teeth on the inner wall of the bottom of the annular groove, so that the first rotating shaft 7 can rotate under the cooperation of the first bevel gear 14 and the teeth. As the first rotating shaft 7 rotates, the first auger blade 8 can rotate in the sleeve 6, so that the upper medium and the lower medium are transported upward along the sleeve 6. In the process of the upper medium and the lower medium moving upward along the sleeve 6, the upper medium The upper and lower media can press the pressure plate 9 upward under the action of the auger blades, so that the compression spring 10 is gradually compressed. As the pressure plate 9 moves upward, when the bottom of the pressure plate 9 is higher than the bottom inner wall of the discharge hole 11, the upper and lower media in the sleeve 6 can be discharged through the discharge hole 11. Before the upper and lower media are discharged from the sleeve 6 through the discharge hole 11, the compression spring 10 can always apply pressure to the upper and lower media through the pressure plate 9, so that the upper and lower media can be merged faster under the action of pressure, thereby improving the emulsification efficiency of the upper and lower media.

[0029] like Figure 3 and Figure 6As shown, the mixing assembly includes a second rotating shaft 15, a plurality of stirring rods 16 and a second bevel gear 17, the second rotating shaft 15 is arranged at an angle, the top end of the second rotating shaft 15 is rotatably connected to the surface of the driving shaft 3, the bottom end of the second rotating shaft 15 is rotatably inserted into the protective ring 13, the second bevel gear 17 is fixedly sleeved on the bottom end of the second rotating shaft 15, and the second bevel gear 17 is meshed with the teeth on the inner wall of the bottom of the annular groove, the plurality of stirring rods 16 are uniformly and vertically fixedly connected to the surface of the second rotating shaft 15, the sieve plate 5 is arranged at an angle, the sieve plate 5 and the plurality of stirring rods 16 on the second rotating shaft 15 are located at the same height area, and the sieve plate 5 can convey the raw materials downward; By providing a mixing assembly, during the rotation of the driving shaft 3, the second rotating shaft 15 can move around the driving shaft 3 under the drive of the driving shaft 3, and as the second rotating shaft 15 moves, the second bevel gear 17 at the bottom end of the second rotating shaft 15 can roll against the teeth on the bottom groove wall of the annular groove, so that the second rotating shaft 15 can rotate under the cooperation of the second bevel gear 17 and the teeth, and as the second rotating shaft 15 rotates, the stirring rod 16 on the second rotating shaft 15 can stir and mix the upper medium and the lower medium after being divided by the sieve plate 5, and then cooperate with the sleeve 6, the sieve plate 5, and the second rotating shaft 15 to stir the upper medium and the lower medium in the stirring tank 1, thereby improving the mixing efficiency and mixing effect of the lower medium and the upper medium.

[0030] like Figure 3 As shown, a second auger blade 18 is provided between the two groups of the stirring devices, the second auger blade 18 is fixedly connected to the driving shaft 3, the diameter of the second auger blade 18 gradually increases from top to bottom, and the conveying direction of the second auger blade 18 to the raw material is opposite to the conveying direction of the sieve plate 5 to the raw material; By providing the second auger blade 18, during the rotation of the drive shaft 3, the second auger blade 18 can transport the emulsion in the stirring tank 1 upward, thereby cooperating with the sieve plate 5 to transport the emulsion downward, so that the emulsion in the stirring tank 1 can flow up and down from the side wall of the stirring tank 1 to the middle of the stirring tank 1 and form a circulation, thereby improving the emulsification effect and emulsification efficiency of the emulsion in the stirring tank 1.

[0031] like Figure 4 and Figure 5 As shown, the diameter of the pressing plate 9 matches the inner diameter of the sleeve 6, and the edge of the pressing plate 9 protrudes upward, and the height of the upward protruding portion of the edge of the pressing plate 9 is greater than the opening height of the discharge hole 11, the initial height of the pressing plate 9 is lower than the height of the discharge hole 11, and the top edge of the upward protruding portion of the pressing plate 9 is always higher than the top inner wall of the discharge hole 11; By designing the edge of the pressing plate 9 to be protruding upward, the pressing plate 9 can always cover the space on its top during the movement of the pressing plate 9, thereby preventing the upper layer medium or the lower layer medium from entering the space on the top of the pressing plate 9 during the mixing process, thereby preventing the product from remaining in the space on the top of the pressing plate 9.

[0032] The anti-skin aging serine provided by the invention is applied to emulsion, water, cream, essence, facial mask, soap, shampoo, conditioner, shower gel and cleanser in cosmetics.

[0033] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them.

Claims

1. A process for preparing serine for resisting skin aging, characterized in that: The device used for preparing serine comprises a stirring tank (1), wherein a tank cover (2) is arranged on the top of the stirring tank (1), a driving shaft (3) is inserted through the tank cover (2), the top end of the driving shaft (3) is transmission-connected to a motor (4), two groups of stirring devices are arranged on the driving shaft (3), the stirring device is composed of a plurality of stirring components, the stirring components comprising a sieve plate (5), a sleeve (6), a first rotating shaft (7), a first auger blade (8), a pressing plate (9), a pressing spring (10) and a driving component, and a mixing component is arranged between two adjacent sieve plates (5); The specific preparation process of the serine for resisting skin aging comprises the following steps: Step 1: Place methanol in a stirring tank (1), add cystine and chloroform in an ice-salt bath, and stir to react for 12 hours. When the reaction is complete, concentrate to 1 / 2 of the original volume, stand for crystallization, and collect and dry. Step 2: Cysteine ​​dimethyl ester dihydrochloride was chlorinated in chloroform medium, introduced with chlorine gas, and chlorinated at low temperature and normal pressure for 48 hours. After the reaction was completed, a small amount of ether was added to the reaction solution, and dry air was blown in to drive away excess halogen and HCL, and B-chloroalanine methyl ester hydrochloride was precipitated at room temperature; Step 3: Remove the ester group of the prepared B-chloroalanine methyl ester hydrochloride in 2NNaOH, adjust the pH to 6.5 with dilute HCL, desalt on a column, and concentrate and crystallize to obtain L-serine.

2. The process for preparing serine for resisting skin aging according to claim 1, characterized in that: The sieve plate (5) is fixedly connected to the surface of the drive shaft (3); the sleeve (6) is in an inclined state, and the sleeve (6) is fixedly connected to the side of the sieve plate (5) away from the drive shaft (3); the first rotating shaft (7) is located at the axis of the sleeve (6); the top end of the first rotating shaft (7) is rotatably connected to the inner wall of the top end of the sleeve (6); the first auger blade (8) is fixedly connected to the surface of the first rotating shaft (7); the pressure plate (9) is rotatably sleeved at a position near the top end of the first rotating shaft (7); the two ends of the clamping spring (10) are respectively fixedly connected to the upward side of the pressure plate (9) and the inner wall of the top of the sleeve (6); and a plurality of discharge holes (11) are penetrated through the surface of the sleeve (6) near the top end.

3. The process for preparing serine for resisting skin aging according to claim 2, characterized in that: The driving assembly comprises an annular track (12), a protective ring (13) and a plurality of first bevel gears (14); the annular track (12) is fixedly connected to the side wall of the mixing tank (1); an annular groove is provided on the inner side of the annular track (12); teeth are evenly arranged on the bottom groove wall of the annular groove; the protective ring (13) is rotatably mounted on the inner side of the opening of the annular groove; the plurality of first bevel gears (14) are fixedly sleeved on the bottom ends of the plurality of first rotating shafts (7) one by one; the bottom ends of the first rotating shafts (7) are rotatably inserted through the protective ring (13); the first bevel gears (14) are located in the annular groove, and the first bevel gears (14) are meshed with the teeth on the bottom inner wall of the annular groove.

4. The process for preparing serine for resisting skin aging according to claim 3, characterized in that: The mixing assembly comprises a second rotating shaft (15), a plurality of stirring rods (16) and a second bevel gear (17); the second rotating shaft (15) is arranged at an angle; the top end of the second rotating shaft (15) is rotationally connected to the surface of the driving shaft (3); the bottom end of the second rotating shaft (15) is rotationally inserted into the protective ring (13); the second bevel gear (17) is fixedly sleeved on the bottom end of the second rotating shaft (15); the second bevel gear (17) is meshed with teeth on the inner wall of the bottom of the annular groove; and the plurality of stirring rods (16) are uniformly and vertically fixedly connected to the surface of the second rotating shaft (15).

5. The process for preparing serine for resisting skin aging according to claim 4, characterized in that: A second auger blade (18) is provided between the two groups of stirring devices. The second auger blade (18) is fixedly connected to the drive shaft (3). The diameter of the second auger blade (18) gradually increases from top to bottom, and the conveying direction of the second auger blade (18) for the raw material is opposite to the conveying direction of the sieve plate (5) for the raw material.

6. The process for preparing serine for resisting skin aging according to claim 5, characterized in that: The diameter of the pressing plate (9) matches the inner diameter of the sleeve (6), and the edge of the pressing plate (9) protrudes upwards, and the height of the upwardly protruding portion of the edge of the pressing plate (9) is greater than the opening height of the discharge hole (11), the initial height of the pressing plate (9) is lower than the height of the discharge hole (11), and the top edge of the upwardly protruding portion of the pressing plate (9) is always higher than the top inner wall of the discharge hole (11).

7. The process for preparing serine for resisting skin aging according to claim 6, characterized in that: The sieve plate (5) is arranged in an inclined manner, the sieve plate (5) and the plurality of stirring rods (16) on the second rotating shaft (15) are located in the same height area, and the sieve plate (5) is capable of conveying the raw materials downwards.

8. The process for preparing serine for resisting skin aging according to claim 7, characterized in that: The top of the tank cover (2) is connected to two feed pipes (19), and the side of the stirring tank (1) near the bottom is connected to a discharge pipe (20).

9. The process for preparing serine for resisting skin aging according to claim 8, characterized in that: The diameter of the first auger blade (8) matches the inner diameter of the sleeve (6), and the length of the first auger blade (8) is the same as the distance from the bottom of the pressure plate (9) to the bottom end of the sleeve (6) in the initial state.

10. An application of the serine preparation process for resisting skin aging according to claim 9, characterized in that: Used in lotions, water, creams, essences, facial masks, soaps, shampoos, conditioners, shower gels and cleansers in cosmetics.

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