Reaction drainage structure of high-flux synthesizer

Abstract

The invention discloses a reaction drainage structure of a high-throughput synthesizer, and belongs to the technical field of DNA synthesis. The device comprises a synthesis plate, a plurality of reaction cavities and a plurality of liquid discharge micropores are formed in the synthesis plate, and the reaction cavities are communicated with the liquid discharge micropores; the gas inlet unit comprises a gas distribution plate, the gas distribution plate is provided with a plurality of gas distribution holes, the gas distribution holes are in one-to-one correspondence with the reaction cavities, the gas distribution plate can move after being driven to enable the gas distribution holes and the reaction cavities to be independently communicated or separated from each other, the liquid discharging unit comprises a first sealing gasket, and the upper surface of the first sealing gasket is provided with a plurality of sealing bosses; the sealing bosses are in one-to-one correspondence with the liquid drainage micropores, and the first sealing gasket can move after being driven so that the sealing bosses can abut against or be separated from the bottoms of the liquid drainage micropores. According to the invention, the independent sealing performance of each reaction cavity in the reaction and liquid discharge process is ensured, and the problems of liquid leakage and cross contamination of waste liquid are effectively solved.

Description

Technical Field

[0001] The present application relates to the technical field of DNA synthesis, and in particular to a reaction liquid discharge structure of a high-throughput synthesizer. Background Art

[0002] Chip-based DNA synthesis is a high-throughput DNA synthesis technology that uses an integrated chip as a solid phase carrier to perform synthesis reactions at specific sites on its surface in a high-density, integrated manner, thereby saving reagents while achieving high-throughput synthesis. After each synthesis is completed, the waste liquid needs to be discharged.

[0003] In the related technology, the patent with announcement number CN221156705U discloses a high-pass synthesizer, including a drainage recess and a bottomless tube supporting and heating frame group constructed above the drainage recess. The sealing plate group in the drainage recess can be driven to move back and forth along the height direction of the drainage recess, and then resist or separate from the bottom of the bottomless tube; the bottomless tube can be used for liquid storage or drainage without occupying the space between adjacent bottomless tubes. A plurality of groups of neatly arranged and closely connected bottomless tubes can be arranged on the bottomless tube supporting and heating frame group, and at least ninety-six groups of bottomless tubes can be designed.

[0004] Regarding the above-mentioned related technologies, when the bottom of the bottomless pipe needs to be sealed, the plane of the first sealing gasket is mainly used to abut the bottoms of multiple bottomless pipes. When a certain position of the plane of the first sealing gasket is deformed, it will correspondingly affect other positions of the plane, thereby causing poor sealing. In addition, the waste liquid in each bottomless pipe is discharged by gravity, which will cause problems such as incomplete waste liquid discharge and low discharge efficiency. Summary of the invention

[0005] In order to solve the problems of liquid leakage and incomplete waste liquid discharge, the present application provides a reaction liquid discharge structure of a high-throughput synthesizer.

[0006] In the first aspect, the present application provides a high-throughput synthesizer reaction liquid discharge structure adopts the following technical solution: A reaction liquid discharge structure of a high-throughput synthesizer, comprising: A synthetic plate, in which a plurality of reaction chambers and a plurality of drainage micropores are provided, wherein the reaction chambers are connected to the drainage micropores; An air inlet unit, comprising an air distribution plate, the air distribution plate being provided with a plurality of air distribution holes, the air distribution holes corresponding to the reaction chambers one by one, and the air distribution plate being driven to move so that the air distribution holes and the reaction chambers are connected individually or separated from each other; The liquid discharge unit comprises a first sealing pad, wherein a plurality of sealing bosses are arranged on the upper surface of the first sealing pad, wherein the sealing bosses correspond to the liquid discharge micropores one by one, and the first sealing pad can be moved after being driven so as to make the sealing bosses contact or separate from the bottom of the liquid discharge micropores.

[0007] By adopting the above technical solutions, multiple reaction chambers and drainage micropores on the synthesis plate realize the functions of multi-hole independent reaction and efficient drainage. The gas distribution plate of the air inlet unit can accurately control the pressure of each reaction chamber under the driving action to ensure the uniform flow of gas in each reaction chamber. Each gas distribution hole and the corresponding reaction chamber are individually sealed to ensure that the reagents in the reaction chamber will not splash into the adjacent chamber during drainage, thus eliminating contamination. The first sealing gasket of the drainage unit is cleverly designed. Through the precise docking of the sealing boss and the drainage micropore, it effectively prevents the leakage and cross-contamination of reagents during DNA synthesis, and improves the stability and reliability of the entire system.

[0008] Optionally, the pressure in each reaction chamber is adjustable.

[0009] By adopting the above technical solution, the pressure in each reaction chamber can be adjusted. This not only improves the controllability of the internal environment of each reaction chamber, but also enables the flexible adjustment of reaction parameters under different reaction conditions, thereby optimizing the reaction process and improving synthesis efficiency and product purity. In addition, this design can also effectively avoid overall system failures caused by abnormal pressure in individual reaction chambers, enhancing the stability and reliability of the system.

[0010] Optionally, the upper surface of the synthetic plate is provided with a first convex ring which is connected with the reaction chamber in a one-to-one correspondence, and the first convex ring can abut against the lower surface of the gas separation plate and be connected with the gas separation hole. The lower surface of the synthetic plate is provided with a second convex ring which is connected with the drainage micropores in a one-to-one correspondence, and the second convex ring can abut against the sealing boss.

[0011] By adopting the above technical solution, point-to-surface connection and point-to-point sealing are formed, thereby improving the sealing between the two, further ensuring the independence of each reaction chamber, and avoiding cross contamination.

[0012] Optionally, a first drainage hole is provided on the upper surface of the first sealing gasket, and a plurality of inclined surfaces are provided on the upper surface of the first sealing gasket, and the lowest points of the plurality of inclined surfaces converge at the first drainage hole; the drainage unit also includes a sealing push plate arranged on the lower surface of the first sealing gasket, and a first drainage groove connected to the first drainage hole is provided on the upper surface of the sealing push plate, and the liquid outlet end of the first drainage groove extends to the peripheral side of the sealing push plate.

[0013] By adopting the above technical solution, the design of the first liquid drain hole and multiple inclined surfaces ensures that the waste liquid converges to the first liquid drain hole from different directions, then flows into the first liquid drain groove, and finally is discharged from the peripheral side of the sealing push plate. The purpose of this design is that the waste liquid can be discharged in a diverted manner, and after the waste liquid in the reaction chamber is discharged, the gas is blown to the upper surface of the first sealing gasket, which can more effectively discharge the waste liquid.

[0014] Optionally, the first drainage hole and the multiple inclined surfaces form a drainage area, the upper surface of the first sealing gasket is provided with multiple drainage areas, second drainage holes are provided between adjacent drainage areas, the upper surface of the sealing push plate is provided with a second drainage groove, and the second drainage hole is connected to the second drainage groove.

[0015] By adopting the above technical solution, the accumulation of waste liquid on the upper surface of the first sealing gasket is avoided, and the drainage efficiency is improved. At the same time, the second drainage hole arranged between adjacent drainage areas further enhances the rationality of the waste liquid flow path, so that the waste liquid between different drainage areas can be smoothly merged into the first drainage groove, preventing the occurrence of waste liquid retention and blockage.

[0016] Optionally, a plurality of third liquid drainage holes are provided on the upper surface of the first sealing gasket, and the plurality of third liquid drainage holes are arranged close to the peripheral side of the first sealing gasket; a third liquid drainage groove corresponding one-to-one to the third liquid drainage holes is provided on the upper surface of the sealing push plate, and the liquid outlet end of the third liquid drainage groove extends to the peripheral side of the sealing push plate.

[0017] By adopting the above technical solution, waste liquid is prevented from being retained in the edge area of ​​the first sealing pad, and the design of the third liquid row groove allows waste liquid to be quickly drawn out from the peripheral side of the sealing push plate to prevent waste liquid accumulation and pollution. The purpose of this design in the present application is to maximize the waste liquid discharge path, improve the waste liquid discharge efficiency and discharge effect, and also to maximize the structural strength of the sealing push plate and extend its service life.

[0018] Optionally, the reaction drainage structure also includes a push plate support seat, a push plate center rod is provided in the center of the sealing push plate, the push plate center rod is slidably connected to the push plate support seat, and a drainage bin is provided in an inner circumference of the push plate support seat, and the liquid outlet end of the first drainage bin is located above the drainage bin; an annular drip groove is provided on the lower surface of the sealing push plate, and the drip groove is located above the drainage bin, a second sealing gasket is provided on the inner side of the push plate support seat, and the second sealing gasket is arranged around the push plate center rod, and the lower surface of the sealing push plate can abut against the second sealing gasket.

[0019] By adopting the above technical solution, the arrangement of the liquid discharge bin and the liquid dripping tank effectively collects and diverts the waste liquid, preventing the waste liquid from accumulating on the lower surface of the sealing push plate and causing secondary contamination. The use of the second sealing pad further enhances the sealing performance, ensuring that the reagent in the push plate support seat will not leak during the liquid discharge process, thereby improving the overall working efficiency and safety of the equipment.

[0020] Optionally, the air intake unit further includes a positive pressure air intake bin, which is snapped onto the upper surface of the air distribution plate. The positive pressure air intake bin is provided with an air intake cavity, which is connected to the plurality of air distribution holes.

[0021] By adopting the above technical solution, this design not only improves the uniformity of gas distribution, but also enhances the pressure control accuracy in the reaction chamber, thereby improving the stability and efficiency of the drainage process.

[0022] Optionally, the reaction drainage structure also includes a first driving unit for driving the air intake unit to move and a second driving unit for driving the drainage unit to move, the first driving unit and the second driving unit both include a connecting frame, a driving shaft and an eccentric driving wheel, the connecting frame is connected to the air intake unit or the drainage unit, the eccentric driving wheel is fixed on the driving shaft, the eccentric driving wheel is slidably abutted against the inner side of the connecting frame, and when the driving shaft rotates, the eccentric driving wheel is driven to rotate so that the eccentric driving wheel drives the connecting frame to move reciprocatingly.

[0023] By adopting the above technical solution, precise control of the air intake unit and the liquid discharge unit is achieved, and the consistency and stability of the gas flow in the reaction chamber are improved. This design not only simplifies the system structure and reduces manufacturing costs, but also effectively reduces the failure rate caused by mechanical wear and improves the reliability and service life of the equipment.

[0024] Optionally, a detection contact piece is provided at the end of the driving shaft, and the detection contact piece is arranged opposite to the eccentric driving wheel. The reaction drainage structure also includes a position sensor, and the detection contact piece can trigger the position sensor to detect the position of the gas distribution plate or the first sealing gasket.

[0025] By adopting the above technical solution, the advantage of installing the detection contact piece at the shaft end is that the relative position of the detection contact piece and the eccentric drive wheel in the angular direction always remains unchanged, and there is no need to worry about changes in position parameters during disassembly and maintenance.

[0026] In summary, the present application includes at least one of the following beneficial technical effects: 1. The combined design of the gas separator and the first sealing gasket realizes the precise docking and separation between the reaction chamber and the drainage micropores, ensuring the independent sealing of each reaction chamber during the drainage process, effectively avoiding the problems of waste liquid overflow and cross contamination; 2. Both the air intake unit and the liquid discharge unit are equipped with an eccentric wheel mechanism driven by a motor, which can accurately control the movement position of each component, improve the automation degree and operation accuracy of the system, and significantly improve the liquid discharge efficiency and stability; 3. The inclined surface design and drainage groove structure on the first gasket optimize the waste liquid drainage path, reduce the residence time of the waste liquid on the surface of the first gasket, further reduce the risk of contamination, and enhance the overall drainage effect.

[0027] 4. The pressure in each reaction chamber is adjustable, which not only improves the controllability of the internal environment of each reaction chamber, but also enables the flexible adjustment of reaction parameters under different reaction conditions, thereby optimizing the reaction process, improving synthesis efficiency and product purity. In addition, this design can also effectively avoid overall system failures caused by abnormal pressure in individual reaction chambers, and enhance the stability and reliability of the system. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present application.

[0029] Figure 2 It is a cross-sectional view of the reaction drainage structure of an embodiment of the present application.

[0030] Figure 3 This is a cross-sectional view of the embodiment of the present application, which mainly shows the synthesis plate, the air intake unit and the liquid discharge unit.

[0031] Figure 4 It is an exploded view of the first sealing gasket and the sealing push plate of the embodiment of the present application.

[0032] Description of reference numerals: 1. Synthetic plate; 11. Reaction chamber; 12. Liquid discharge micropore; 13. First convex ring; 14. Second convex ring; 2. Air intake unit; 21. Air distributor plate; 211. Air distributor hole; 212. Air distributor plate body; 213. Air distributor cushion; 214. Sealing part; 22. Positive pressure air intake chamber; 221. Air intake chamber; 3. Liquid discharge unit; 31. First sealing cushion; 311. Sealing boss; 312. First liquid discharge hole; 313. Inclined surface; 314. Second liquid discharge hole; 315. Third Drain hole; 32, sealing push plate; 321, first liquid drain groove; 322, second liquid drain groove; 323, third liquid drain groove; 324, drip groove; 33, push plate center rod; 34, second sealing pad; 4, heating module; 5, push plate support seat; 51, liquid drain bin; 52, liquid drain interface; 61, support frame; 62, connecting frame; 63, drive shaft; 64, eccentric drive wheel; 65, drive motor; 66, detection contact piece; 67, position sensor; 7, mobile module. DETAILED DESCRIPTION

[0033] The following will be combined with the attached Figure 1-Figure 4 , the technical solutions in the embodiments of the present invention are clearly and completely described. The described embodiments are only possible technical implementations of the present invention, not all possible implementations. Those skilled in the art can completely combine the embodiments of the present invention to obtain other embodiments without creative work, and these embodiments are also within the scope of protection of the present invention.

[0034] The reaction liquid discharge structure of the high-throughput synthesizer provided in the embodiment of the present application is as follows: Figure 1-3, including a synthesis plate 1, an air intake unit 2 and a liquid discharge unit 3. A plurality of reaction chambers 11 and a plurality of liquid discharge micropores 12 are provided in the synthesis plate 1, and the reaction chambers 11 are connected with the liquid discharge micropores 12. The air intake unit 2 includes a gas separation plate 21, and a plurality of gas separation holes 211 are provided on the gas separation plate 21. The gas separation holes 211 correspond to the reaction chambers 11 one by one. The gas separation plate 21 can be moved after being driven so that the gas separation holes 211 and the reaction chambers 11 are connected separately or separated from each other. The liquid discharge unit 3 includes a first sealing gasket 31, and a plurality of sealing bosses 311 are provided on the upper surface of the first sealing gasket 31. The sealing bosses 311 correspond to the liquid discharge micropores 12 one by one. The first sealing gasket 31 can be moved after being driven so that the sealing bosses 311 are against or separated from the bottom of the liquid discharge micropores 12.

[0035] Specifically, the reaction chamber 11 and the drainage micropores 12 on the synthesis plate 1 are designed to ensure the independence of each reaction position and avoid cross contamination. Optionally, a chip can be placed in the reaction chamber 11, and the chip is used as a solid phase carrier. After the reagent solution is injected into the reaction chamber 11, the reagent solution reacts with the chip. After one reaction is completed, the reaction drainage structure of the present application is used to drain the waste liquid in the reaction chamber 11, and the next round of reaction and drainage is carried out.

[0036] Reference Figure 2 and Figure 3 Preferably, the synthetic plate 1 can be made of metal material. In this case, a heating module 4 can be set on the periphery of the synthetic plate 1. The heating module 4 is used to heat the synthetic plate 1 to adjust the temperature inside the reaction chamber 11, thereby achieving more precise reaction control.

[0037] In a preferred embodiment, the air intake unit 2 includes an air distribution plate 21 and a positive pressure air intake chamber 22. The positive pressure air intake chamber 22 is buckled on the upper surface of the air distribution plate 21. The positive pressure air intake chamber 22 is provided with an air intake chamber 221, and the air intake chamber 221 is connected to a plurality of air distribution holes 211. Positive pressure gas is introduced into the air intake chamber 221, and the positive pressure gas enters each reaction chamber 11 independently through the air distribution holes 211 to discharge the waste liquid in the reaction chamber 11. This solution ensures that the reagent in the reaction chamber 11 will not splash into the adjacent chamber during the discharge, thereby preventing pollution.

[0038] In addition, when the sealing boss 311 does not open the drainage micropores 12, if the positive pressure gas continues to pass into the air inlet chamber 221, the pressure in each reaction chamber 11 can be regulated, and then the pressure during the reaction process can be regulated to meet a wider range of reaction conditions. At this time, the gas introduced is an inert gas. Optionally, a sealing ring is provided between the gas distribution plate 21 and the positive pressure air inlet bin 22 to improve the sealing of the air inlet chamber 221. In other embodiments, each gas distribution hole 211 can also be connected to a ventilation pipe separately, and the pressure in each reaction chamber 11 can be regulated more accurately and independently.

[0039] Preferably, the air separation plate 21 includes an overlapping air separation plate body 212 and an air separation pad 213, the air separation holes 211 are arranged on the air separation plate body 212 and the air separation pad 213, the air separation plate body 212 is connected to the positive pressure air inlet chamber 22, the air separation pad 213 can abut against the upper surface of the synthetic board 1, and the air separation pad 213 is a flexible pad, thereby improving the contact sealing between the air separation pad 213 and the synthetic board 1.

[0040] In a preferred embodiment, the upper surface of the synthesis plate 1 is provided with a first convex ring 13 that is in one-to-one correspondence with the reaction chamber 11. The first convex ring 13 can abut against the lower surface of the gas separation pad 213 and communicate with the gas separation hole 211. At the same time, a sealing portion 214 is provided around the lower surface of the gas separation pad 213, and the sealing portion 214 abuts against the upper surface of the synthesis plate 1. The sealing portion 214 surrounds all the circumferences of the first convex ring 13 to further improve the sealing performance.

[0041] Preferably, the drainage unit 3 includes a first sealing gasket 31 and a sealing push plate 32. The first sealing gasket 31 can be fixed on the upper surface of the sealing push plate 32 by a sealing gasket pressing sheet. The lower surface of the synthetic board 1 is provided with a second convex ring 14 that is in one-to-one correspondence with the drainage micropores 12, and the sealing boss 311 can abut against the second convex ring 14. By driving the sealing push plate 32, the first sealing gasket 31 is driven to move up and down, so that the sealing boss 311 and the second convex ring 14 abut or separate, thereby realizing the opening and closing of the drainage micropores 12. This double convex ring design not only enhances the sealing effect, but also reduces the risk of leakage caused by wear.

[0042] Reference Figure 3 and Figure 4 When the sealing boss 311 is separated from the second convex ring 14, the drainage micropore 12 is opened, and the waste liquid flows to the upper surface of the first sealing pad 31. At this time, the upper surface of the first sealing pad 31 is provided with a first drainage hole 312, and the upper surface of the first sealing pad 31 is provided with a plurality of inclined surfaces 313, and the lowest points of the plurality of inclined surfaces 313 converge at the first drainage hole 312. The upper surface of the sealing push plate 32 is provided with a first drainage groove 321 connected with the first drainage hole 312, and the liquid outlet end of the first drainage groove 321 extends to the peripheral side of the sealing push plate 32. Waste liquid can flow and be discharged from the first drainage hole 312 and the first drainage groove 321.

[0043] To further optimize the drainage effect, a first drainage hole 312 and multiple inclined surfaces 313 form a drainage area, and multiple drainage areas are provided on the upper surface of the first sealing gasket 31. In this embodiment, four drainage areas are provided, and the four drainage areas are arranged in a "field" shape. A second drainage hole 314 is also provided between adjacent drainage areas, and a second drainage groove 322 is provided on the upper surface of the sealing push plate 32, and the second drainage hole 314 is connected to the second drainage groove 322.

[0044] Preferably, a plurality of third liquid drainage holes 315 are further provided on the upper surface of the first sealing gasket 31, and the plurality of third liquid drainage holes 315 are arranged near the peripheral side of the first sealing gasket 31, and a third liquid drainage groove 323 corresponding to the third liquid drainage holes 315 is provided on the upper surface of the sealing push plate 32, and the liquid outlet end of the third liquid drainage groove 323 extends to the peripheral side of the sealing push plate 32. Optionally, the bottoms of the first liquid drainage groove 321, the second liquid drainage groove 322 and the third liquid drainage groove 323 are inclined so that the waste liquid can be quickly discharged under the action of gravity. The purpose of such a design of the present application is to maximize the waste liquid discharge path, improve the waste liquid discharge efficiency and discharge effect, and also to maximize the structural strength of the sealing push plate 32 and extend its service life.

[0045] Optionally, the reaction drainage structure also includes a push plate support seat 5, which is a central concave support seat. The push plate support seat 5 is connected to a heating module 4 above the push plate support seat 5, and the heating module 4 is connected to the synthesis plate 1. When the push plate support seat 5 moves, it can synchronously drive the synthesis plate 1 to move.

[0046] Among them, a push plate center rod 33 is provided at the center of the lower surface of the sealing push plate 32, and the push plate center rod 33 penetrates the push plate support seat 5 and is slidably connected to the push plate support seat 5. A drainage bin 51 is provided around the inner circumference of the push plate support seat 5, and the liquid outlet ends of the first drainage groove 321, the second drainage groove 322 and the third drainage groove 323 are all located above the drainage bin 51. An annular drip groove 324 is provided on the lower surface of the sealing push plate 32, and the drip groove 324 is located above the drainage bin 51. The arrangement of the drainage bin 51 and the drip groove 324 effectively collects and guides waste liquid, and prevents waste liquid from flowing along the lower surface of the sealing push plate 32 to the push plate center rod 33.

[0047] Further, a second sealing pad 34 is provided inside the push plate support seat 5, and the second sealing pad 34 is arranged around the push plate center rod 33. When draining, the sealing push plate 32 moves down and the lower surface abuts against the second sealing pad 34. The use of the second sealing pad 34 further enhances the sealing performance, ensuring that the reagent in the push plate support seat 5 will not leak during the drainage process. Optionally, the second sealing pad 34 is detachably mounted on the inside of the push plate support seat 5 by screws, which is convenient for quick replacement. The outer side of the push plate support seat 5 is connected to a drainage interface 52 that is connected to the drainage bin 51, so that the waste liquid can be discharged through the drainage interface 52.

[0048] Reference Figure 2, the reaction liquid discharge structure also includes a first drive unit for driving the air intake unit 2 to move and a second drive unit for driving the liquid discharge unit 3 to move. Preferably, the first drive unit and the second drive unit both include a support frame 61, a connecting frame 62, a drive shaft 63 and an eccentric drive wheel 64, the connecting frame 62 is slidably connected in the support frame 61 along the height direction, and the connecting frame 62 is connected to the air intake unit 2 or the liquid discharge unit 3. Specifically, one connecting frame 62 is connected to the positive pressure air intake bin, and the other connecting frame 62 is connected to the push plate center rod 33. The eccentric drive wheel 64 is fixed on the drive shaft 63, the eccentric drive wheel 64 is slidably abutted against the inner side of the connecting frame 62, the drive shaft 63 is rotatably connected to the support frame 61, and when the drive shaft 63 rotates, the eccentric drive wheel 64 is driven to rotate so that the eccentric drive wheel 64 drives the connecting frame 62 to reciprocate. Optionally, a driving motor 65 is installed on the outer side of the support frame 61, and the output end of the driving motor 65 is connected to the driving shaft 63, and the driving motor 65 is used to drive the driving shaft 63 to rotate, thereby controlling the movement of the air intake unit 2 or the liquid discharge unit 3.

[0049] In order to accurately control the position of the air intake unit 2 or the liquid discharge unit 3, a detection contact piece 66 is provided at the end of the drive shaft 63. The detection contact piece 66 is arranged opposite to the eccentric drive wheel 64. A position sensor 67 is installed on the outer wall of the support frame 61. The detection contact piece 66 can trigger the position sensor 67 to detect the position of the air distribution plate 21 or the first sealing gasket 31. This design can not only accurately locate the position of each component, but also provide timely feedback on abnormal situations, which is convenient for maintenance and debugging. At the same time, the advantage of installing the detection contact piece 66 at the end of the shaft is that the relative position of the detection contact piece 66 and the eccentric drive wheel 64 in the angular direction always remains unchanged, and there is no need to worry about changes in position parameters during disassembly and maintenance.

[0050] In other embodiments, the first driving unit and the second driving unit may also be other devices capable of driving the air intake unit 2 and the liquid discharge unit 3 to move, such as a screw motor device.

[0051] Reference Figure 1 Optionally, a movable module 7 is connected to the bottom of the support frame 61 of the second driving unit, and the movable module 7 is used to drive the synthetic board 1 to reciprocate along a single axis direction. The support frame 61 of the first driving unit is fixed at a certain position. When the movable module 7 moves the synthetic board 1 to the bottom of the air intake unit 2, the first driving unit can be used to control the air intake unit 2 to achieve the closing or separation of the air intake unit 2 and the synthetic board 1.

[0052] Optionally, a plurality of synthesis plates 1 and a plurality of air intake units 2 and liquid drainage units 3 may be arranged in a support frame 61. In the present embodiment, two synthesis plates 1 and two air intake units 2 and liquid drainage units 3 are arranged in a support frame 61, which is equivalent to two systems. The two systems are independently controlled to further improve the synthesis efficiency.

[0053] The implementation principle of this embodiment is: by rationally designing the structure of the synthesis plate 1, the gas separation plate 21 and the first sealing gasket 31, an efficient multi-hole position drainage function is achieved. Especially under high pressure environment, the multiple sealing design of the first sealing gasket 31 and the sealing push plate 32 effectively prevents the waste liquid from overflowing, ensuring the accuracy and reliability of the experimental results. In addition, by independently regulating the pressure of each reaction chamber 11, the reaction conditions can be better controlled and the reaction efficiency can be improved.

[0054] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A reaction liquid discharge structure of a high-throughput synthesizer, characterized in that: include: A synthetic plate (1) having a plurality of reaction chambers (11) and a plurality of liquid drainage micropores (12) formed therein, wherein the reaction chambers (11) are in communication with the liquid drainage micropores (12); An air inlet unit (2) comprising an air distribution plate (21), the air distribution plate (21) being provided with a plurality of air distribution holes (211), the air distribution holes (211) corresponding one to one with the reaction chamber (11), the air distribution plate (21) being capable of moving after being driven so that the air distribution holes (211) and the reaction chamber (11) are individually connected or separated from each other; The liquid discharge unit (3) comprises a first sealing gasket (31), wherein a plurality of sealing bosses (311) are provided on the upper surface of the first sealing gasket (31), wherein the sealing bosses (311) correspond one-to-one to the liquid discharge micropores (12), and when the first sealing gasket (31) is driven, it can move so that the sealing bosses (311) abut against or separate from the bottom of the liquid discharge micropores (12).

2. The reaction liquid discharge structure of a high-throughput synthesizer according to claim 1, characterized in that: The pressure in each reaction chamber (11) is adjustable.

3. The reaction liquid discharge structure of a high-throughput synthesizer according to claim 1, characterized in that: The upper surface of the synthesis plate (1) is provided with a first convex ring (13) which is in one-to-one communication with the reaction chamber (11); the first convex ring (13) can abut against the lower surface of the gas separation plate (21) and is in communication with the gas separation hole (211); the lower surface of the synthesis plate (1) is provided with a second convex ring (14) which is in one-to-one communication with the liquid discharge micropores (12); the second convex ring (14) can abut against the sealing boss (311).

4. The reaction liquid discharge structure of a high-throughput synthesizer according to claim 1, characterized in that: The first sealing gasket (31) has a first liquid drainage hole (312) formed on its upper surface, and a plurality of inclined surfaces (313) formed on its upper surface, wherein the lowest points of the plurality of inclined surfaces (313) converge at the first liquid drainage hole (312); the liquid drainage unit (3) further comprises a sealing push plate (32) arranged on the lower surface of the first sealing gasket (31), and a first liquid drainage groove (321) communicating with the first liquid drainage hole (312) is formed on its upper surface, and a liquid outlet end of the first liquid drainage groove (321) extends to the peripheral side of the sealing push plate (32).

5. The reaction liquid discharge structure of a high-throughput synthesizer according to claim 4, characterized in that: The first liquid drainage hole (312) and the plurality of inclined surfaces (313) form a liquid drainage area, the first sealing pad (31) is provided with a plurality of liquid drainage areas on its upper surface, second liquid drainage holes (314) are provided between adjacent liquid drainage areas, the sealing push plate (32) is provided with a second liquid drainage groove (322) on its upper surface, and the second liquid drainage hole (314) is connected to the second liquid drainage groove (322).

6. The reaction liquid discharge structure of a high-throughput synthesizer according to claim 5, characterized in that: A plurality of third liquid drainage holes (315) are provided on the upper surface of the first sealing gasket (31), and the plurality of third liquid drainage holes (315) are arranged close to the peripheral side of the first sealing gasket (31). A third liquid drainage groove (323) corresponding one-to-one to the third liquid drainage holes (315) is provided on the upper surface of the sealing push plate (32), and the liquid outlet end of the third liquid drainage groove (323) extends to the peripheral side of the sealing push plate (32).

7. The reaction liquid discharge structure of a high-throughput synthesizer according to claim 4, characterized in that: The reaction liquid discharge structure also includes a push plate support seat (5), a push plate center rod (33) is provided at the center of the sealing push plate (32), the push plate center rod (33) is slidably connected to the push plate support seat (5), a liquid discharge bin (51) is provided around the inner circumference of the push plate support seat (5), and the liquid outlet end of the first liquid discharge groove (321) is located above the liquid discharge bin (51); an annular liquid drip groove (324) is provided on the lower surface of the sealing push plate (32), and the liquid drip groove (324) is located above the liquid discharge bin (51); a second sealing gasket (34) is provided on the inner side of the push plate support seat (5), and the second sealing gasket (34) is provided around the circumference of the push plate center rod (33), and the lower surface of the sealing push plate (32) can abut against the second sealing gasket (34).

8. The reaction liquid discharge structure of a high-throughput synthesizer according to claim 1, characterized in that: The air intake unit (2) further comprises a positive pressure air intake bin (22), the positive pressure air intake bin (22) being snapped onto the upper surface of the air distribution plate (21), the positive pressure air intake bin (22) being provided with an air intake cavity (221), the air intake cavity (221) being in communication with the plurality of air distribution holes (211).

9. The reaction liquid discharge structure of a high-throughput synthesizer according to claim 1, characterized in that: The reaction liquid discharge structure further comprises a first drive unit for driving the air intake unit (2) to move and a second drive unit for driving the liquid discharge unit (3) to move. The first drive unit and the second drive unit both comprise a connecting frame (62), a drive shaft (63) and an eccentric drive wheel (64). The connecting frame (62) is connected to the air intake unit (2) or the liquid discharge unit (3). The eccentric drive wheel (64) is fixed on the drive shaft (63). The eccentric drive wheel (64) is in sliding contact with the inner side of the connecting frame (62). When the drive shaft (63) rotates, the eccentric drive wheel (64) is driven to rotate so that the eccentric drive wheel (64) drives the connecting frame (62) to move back and forth.

10. The reaction liquid discharge structure of a high-throughput synthesizer according to claim 9, characterized in that: A detection contact piece (66) is provided at the end of the driving shaft (63), and the detection contact piece (66) is arranged opposite to the eccentric driving wheel (64). The reaction liquid discharge structure also includes a position sensor (67), and the detection contact piece (66) can trigger the position sensor (67) to detect the position of the gas distribution plate (21) or the first sealing gasket (31).

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