Nucleic acid extraction reagent filling device

Abstract

The invention relates to the technical field of reagent filling, and discloses a nucleic acid extraction reagent filling device which comprises a filling seat, a rotary worm gear table is rotatably arranged in an inner cavity of the filling seat, a center gear pipe is rotatably connected to the middle of the rotary worm gear table, and mounting grooves in a circumferential array are formed in the periphery of the rotary worm gear table; a mounting groove is formed in the base, a sleeve is rotationally connected into the mounting groove, a positioning core cylinder is rotationally connected into the sleeve, a sponge fixing ring is fixedly connected to the top of an inner cavity of the positioning core cylinder, through grooves in a circumferential array are formed in the side wall of the positioning core cylinder, slopes are arranged in the through grooves, and elastic abutting blocks are movably connected to the slopes. The sponge fixing ring is matched with the elastic abutting block, so that a reagent tube reaches a standard receiving body position before filling, the fixing control effect is good, it is guaranteed that the reagent tube stably and reliably receives a reagent subsequently, and the reagent tube is cooperatively controlled to be inclined and rotationally filled, so that bubbles and splashing caused by direct flushing and single-point filling are avoided.

Description

Technical Field

[0001] The invention relates to the technical field of reagent filling, and in particular to a nucleic acid extraction reagent filling device. Background Art

[0002] At present, the detection of fever syndrome at ports includes a variety of pathogens, and the use of nucleic acid extraction reagents in whole blood, serum, plasma and other samples, as well as various body fluid samples such as saliva and urine, can extract, enrich and purify viral nucleic acids. The processed products can be used for clinical in vitro testing. Correspondingly, in the infectious disease prevention and control scenarios at ports, efficient and accurate filling of nucleic acid extraction reagents is a key link to ensure high-throughput detection of pathogens.

[0003] Chinese patent CN219383011U discloses a nucleic acid extraction reagent filling device, which belongs to the field of reagent production technology, and includes a bottom plate, a support frame is fixedly connected to the top of the bottom plate, a storage box is slidably connected to the inner side of the bottom plate, and a baffle is fixedly connected to one side of the storage box. The beneficial effect is that the nucleic acid extraction reagent filling device can hold and place the reagent tube by setting the storage box, and can drive the placement plate to rotate by driving the motor. While the reagent is injected, other reagent tubes can be loaded and unloaded to ensure the filling efficiency. By setting the limiting hole and the limiting groove, the reagent tube can be initially limited in position. By the second electric push rod working, the second limiting block can be driven to move. With the help of the first limiting block, the reagent tube can be further clamped and fixed to ensure the stability of the reagent tube during filling. By the water pump working, the reagent can be injected into the reagent tube from the hose and the feeding port.

[0004] When the nucleic acid extraction reagent filling device in the above patent is in use, the reagent tube is positioned between the two limit blocks in the limit groove, one of which is controlled by an electric push rod to clamp the reagent tube. During positioning, the control effect of the reagent tube placed in the limit groove to stand upright is not good, and the reagent tube is easy to tilt and fall over. If the reagent tube is not supported in advance when clamped by the two limit blocks, it cannot be placed in a standard filling position, which is prone to leakage or collision with the perfusion needle. In addition, multiple electric push rods are used to fix it at the same time, and the control effect is poor and not stable enough. When the reagent tube is standing upright, the loading port directly perfuses the reagent tube, and the reagent droplets hit the liquid surface vertically, which can easily cause bubbles and splashes in the reagent, resulting in poor filling effect. Summary of the invention

[0005] The purpose of the present invention is to solve the problems of poor positioning leading to filling accidents and direct injection leading to bubbles and splashing in general nucleic acid extraction reagent filling devices during use. The present invention provides a nucleic acid extraction reagent filling device.

[0006] In order to achieve the above-mentioned purpose, the present invention specifically adopts the following technical solutions: A nucleic acid extraction reagent filling device comprises a filling seat, wherein a rotating worm gear platform is rotatably arranged in the inner cavity of the filling seat, a central gear tube is rotatably connected to the middle of the rotating worm gear platform, a circumferential array of mounting grooves is provided on the periphery of the rotating worm gear platform, a sleeve is rotatably connected in the mounting groove, a positioning core barrel is rotatably connected in the sleeve, a sponge fixing ring is fixedly connected to the top of the inner cavity of the positioning core barrel, a circumferential array of through grooves is provided on the side wall of the positioning core barrel, a slope is provided in the through groove, an elastic resistance block is movably connected to the slope, a torsion tooth column passing through the sleeve is fixedly connected to the bottom of the positioning core barrel, a torsion spring is provided between the torsion tooth column and the bottom of the sleeve, and the torsion tooth column can mesh with the central gear tube; A filling mechanism is arranged on the top of the filling seat, a filling plug is arranged on the filling mechanism, and an L-shaped driving rod which is movably inserted into the central gear tube is fixedly sleeved on the filling plug.

[0007] Furthermore, a driving worm gear meshingly connected to the rotating worm gear platform is rotatably connected to the rear wall of the inner cavity of the filling seat, and the driving worm gear is driven by a driving motor installed on the rear wall of the inner cavity of the filling seat.

[0008] Furthermore, a slip ring is slidably connected between the sleeve and the positioning core tube, the inner wall of the slip ring has a suspension bar extending into the through groove, the suspension bar movably passes through the slope, the elastic force block is slidably clamped at the bottom of the suspension bar, the elastic force block is elastically connected to the inner wall of the slip ring, the elastic force block and the slope have inclined surfaces abutting against each other, and sliding grooves are respectively provided on both sides of the slip ring.

[0009] Furthermore, one end of the elastic resistance block away from the slope is fixedly connected with a rubber friction pad.

[0010] Furthermore, the inner wall of the sleeve is rotatably connected with two symmetrical hollow disks, the inner wall of the hollow disk is provided with an arc groove, the surface of the hollow disk is fixedly connected with a pin column that is movably engaged with the slide groove, the outer wall of the sleeve is slidably engaged with an elastic column, the bottom of the elastic column is provided with a protrusion that is movably engaged with the arc groove, and the elastic column is coaxial with the rotating axis of the sleeve.

[0011] Furthermore, a U-shaped slide is slidably connected to the inner wall of the installation groove, and wedge grooves are provided at both ends of the U-shaped slide close to the axis of the rotating worm gear table, and the wedge groove has a second inclined surface that movably abuts against the elastic column, and a second pin is fixedly connected to the upper end of the U-shaped slide away from the axis of the rotating worm gear table; A guide ring is fixedly connected to the inner wall of the rotating worm gear table, an annular groove is provided at the bottom of the guide ring, and the second pin is movably clamped on the annular groove. The annular groove is composed of an outer ring segment on the left, an inner ring segment on the rear side and a middle ring segment on the right side, and oblique groove transitions are provided between the ring segments, and the inner ring segment on the rear side is located below the filling mechanism.

[0012] Furthermore, the inner walls on both sides of the installation groove are slidably connected with elastic blocks, the elastic block and the U-shaped slide have hook parts that are interlocked with each other, the inner walls on both sides of the installation groove are provided with key grooves corresponding to the elastic block, and a hinge rod is movably connected between the elastic block and the lower outer wall of the sleeve.

[0013] Furthermore, a filling support is fixedly connected to the left side of the top of the filling seat, the filling mechanism is fixedly installed on the filling support, a telescopic filling gun is arranged at the bottom of the filling mechanism, and the L-shaped driving rod is slidably inserted in the front side of the filling support; The central tooth tube is rotatably connected to the bottom of the inner cavity of the filling seat, a spiral groove is provided in the central tooth tube, and a second protrusion movably engaged with the spiral groove is provided on the L-shaped driving rod.

[0014] The beneficial effects of the present invention are as follows: 1. The present invention feeds the reagent tube from the front side and inserts it into the corresponding positioning core barrel. The sponge fixing ring automatically realizes the pre-positioning of the reagent tube, controls the rotating worm gear table to rotate backward, and each elastic resistance block automatically moves down along the slope, and extends from the through groove to gradually approach the reagent tube until the reagent tube is squeezed and a downward force is applied to it. The reagent tube is automatically controlled to be centered and close to the lower wall of the inner cavity of the positioning core barrel, so as to reach the standard receiving position before filling. The fixing control effect is good, which ensures that the subsequent reagent tubes can stably and reliably receive the reagents.

[0015] 2. Before filling the reagent, the present invention transfers the reagent tube to the bottom of the filling mechanism as the rotating worm gear table rotates backward. The sleeve automatically drives the reagent tube to tilt slightly, so that one side of the reagent tube mouth is away from the axis of the rotating worm gear table. At the same time, the positioning core barrel drives the torsion gear column to automatically engage with the center gear tube. When the filling mechanism is filling, the filling plug drives the L-shaped drive rod to automatically control the rotation of the center gear tube, thereby driving the torsion gear column to rotate the tilted reagent tube for filling and drainage, thereby avoiding bubbles and splashing caused by straight-in and single-point filling. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a three-dimensional structural diagram of the filling device of the present invention; Figure 2 The filling seat of the filling device of the present invention is a three-dimensional section Figure 1 ; Figure 3The filling seat of the filling device of the present invention is a three-dimensional section Figure 2 ; Figure 4 It is a partial exploded view of the L-shaped driving rod of the filling device of the present invention; Figure 5 The present invention is a three-dimensional section of the sleeve and the positioning core barrel of the filling device Figure 1 ; Figure 6 It is a three-dimensional cutaway view of the hollow disk portion of the filling device of the present invention; Figure 7 The present invention is a three-dimensional section of the sleeve and the positioning core barrel of the filling device Figure 2 ; Figure 8 It is a three-dimensional structural diagram of the guide ring and U-shaped slide frame of the filling device of the present invention.

[0017] Figure numerals: 1. filling seat; 11. guide ring; 12. annular groove; 13. driving worm; 2. rotating worm gear platform; 21. center gear tube; 22. spiral groove; 3. sleeve; 31. hollow disk; 32. arc groove; 33. pin column one; 34. elastic column; 35. bump one; 4. positioning core tube; 41. sponge fixing ring; 42. slip ring; 43. suspension bar; 44. elastic force block; 45. rubber friction pad; 46. ramp; 47. slide groove; 48. torque gear column; 5. elastic block; 51. hinge rod; 6. U-shaped slide; 61. wedge groove; 62. pin column two; 7. filling support; 71. filling mechanism; 72. filling plug column; 73. L-shaped driving rod; 74. bump two. DETAILED DESCRIPTION

[0018] To make the purpose, technical solution and advantages of the embodiments of the present invention more clear, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0019] Embodiment 1, as Figure 1-Figure 8 As shown, a nucleic acid extraction reagent filling device comprises a filling seat 1, a rotating worm gear platform 2 is rotatably provided in the inner cavity of the filling seat 1, a central gear tube 21 is rotatably connected to the middle of the rotating worm gear platform 2, a circumferential array of mounting grooves are provided on the periphery of the rotating worm gear platform 2, a sleeve 3 is rotatably connected in the mounting groove, a positioning core barrel 4 is rotatably connected in the sleeve 3, a sponge fixing ring 41 is fixedly connected to the top of the inner cavity of the positioning core barrel 4, a circumferential array of through grooves is provided on the side wall of the positioning core barrel 4, a slope 46 is provided in the through groove, an elastic force stopper 44 is movably connected to the slope 46, a torsion tooth column 48 passing through the sleeve 3 is fixedly connected to the bottom of the positioning core barrel 4, a torsion spring is provided between the torsion tooth column 48 and the bottom of the sleeve 3, and the torsion tooth column 48 can mesh with the central gear tube 21; A filling mechanism 71 is arranged on the top of the filling seat 1 , a telescopic filling gun is arranged on the bottom of the filling mechanism 71 , a filling plug 72 is arranged on the filling mechanism 71 , and an L-shaped driving rod 73 movably inserted into the central tooth tube 21 is fixedly sleeved on the filling plug 72 .

[0020] A driving worm 13 meshing with the rotating worm gear stage 2 is rotatably connected to the rear wall of the inner cavity of the filling seat 1 , and the driving worm 13 is driven by a driving motor installed on the rear wall of the inner cavity of the filling seat 1 .

[0021] When in use, a tube supply mechanism can be provided on the front side of the filling seat 1, and a tube taking mechanism can be provided on the left side of the filling seat 1 to cooperate with the reagent tube taking and placing operation. When the reagent tube is supplied from the front side and inserted into the corresponding positioning core tube 4, the sponge fixing ring 41 automatically squeezes the reagent tube to achieve pre-positioning, and controls the driving motor to drive the driving worm 13 to make the rotating worm gear table 2 move backward. Figure 1The reagent tube is automatically controlled to be centered and fixed close to the lower wall of the inner cavity of the positioning core barrel 4 before filling, so that the reagent tube reaches the standard receiving position before filling, ensuring that the subsequent reagent tubes can stably and reliably receive the reagents. As the rotating worm gear table 2 rotates backward to transfer the reagent tube to the bottom of the filling mechanism 71, the sleeve 3 automatically deflects and drives the reagent tube to tilt slightly. , so that one side of the reagent tube mouth is away from the axis of the rotating worm gear table 2, and at the same time, the positioning core barrel 4 drives the torsion gear column 48 to automatically engage with the center gear tube 21. When the inner wall of the side of the reagent tube away from the axis of the rotating worm gear table 2 is just below the telescopic filling gun at the bottom of the filling mechanism 71, the driving motor automatically stops, and the driving worm 13 self-locks the rotating worm gear table 2. The reagent tube is filled with a slightly inclined posture. The operation of the filling mechanism 71 drives the telescopic filling gun port to extend into the reagent tube, and at the same time, the filling plug 72 moves downward to discharge and perfuse. During perfusion, the reagent is released close to the inner wall of the reagent tube, and the lower The generation of bubbles and splashing is reduced, and the tilted filling of the reagent tube is controlled, which is conducive to the slow flow of the reagent along the tube wall, further reducing the generation of bubbles and splashing. As the filling plug 72 moves downward, the L-shaped driving rod 73 is driven to control the rotation of the central tooth tube 21, thereby driving the torsion tooth column 48 to make the reagent tube rotate synchronously for filling, evenly distributing the attachment points of the reagent, achieving drainage, preventing local pressure concentration, and avoiding splashing caused by continuous impact at a single point. After filling, the filling mechanism 71 automatically controls the retractable filling gun to retract, and the filling plug 72 moves up to reset and draw liquid in preparation for the next filling. The corresponding L-shaped driving rod 73 moves up to drive the central gear tube 21 so that the torsion gear column 48 drives the positioning core tube 4 to reset, and the subsequent driving motor drives the driving worm 13 to make the rotating worm gear table 2 continue to rotate to fill the subsequent reagent tubes. After the filled reagent tubes are moved away from the bottom of the filling mechanism 71 and transported to the left side of the filling seat 1, each elastic resistance block 44 automatically moves up along the slope 46 to reset and release the fixation of the reagent tube. The reagent tube only relies on the sponge fixing ring 41 to keep standing, so as to facilitate the tube taking mechanism set on the left side of the filling seat 1 to perform subsequent collection and capping operations.

[0022] Embodiment 2, on the basis of the above embodiment, a slip ring 42 is slidably connected between the sleeve 3 and the positioning core tube 4, the inner wall of the slip ring 42 has a hanging bar 43 extending into the through groove, the hanging bar 43 moves through the slope 46, the elastic stop block 44 is slidably engaged at the bottom of the hanging bar 43, the elastic stop block 44 is elastically connected to the inner wall of the slip ring 42, there is an inclined surface 1 abutting against each other between the elastic stop block 44 and the slope 46, and sliding grooves 47 are respectively provided on both sides of the slip ring 42.

[0023] By designing that the elastic stop block 44 is elastically connected to the inner wall of the slip ring 42, the elastic stop block 44 can be stably located at the top of the slope 46 by utilizing its own elastic force, thereby being contracted in the through groove to avoid interfering with the placement of the reagent tube.

[0024] Embodiment 3: Based on the above embodiment, one end of the elastic stopper 44 away from the slope 46 is fixedly connected to a rubber friction pad 45 .

[0025] With this design, the rubber friction pad 45 is in direct contact with the outer wall of the reagent tube, which ensures that sufficient friction is formed on the reagent tube, ensures that the reagent tube will not loosen or fall out when it is tilted for filling, and avoids damage to the outer wall of the reagent tube.

[0026] Embodiment 4, on the basis of the above embodiment, the inner wall of the sleeve 3 is rotatably connected with two symmetrical hollow disks 31, the inner wall of the hollow disk 31 is provided with an arc groove 32, the surface of the hollow disk 31 is fixedly connected with a pin column 33 which is movably engaged with the slide groove 47, the outer wall of the sleeve 3 is slidably engaged with an elastic column 34, the bottom of the elastic column 34 is provided with a protrusion 35 which is movably engaged with the arc groove 32, and the elastic column 34 is coaxial with the rotation axis of the sleeve 3.

[0027] With this design, when the elastic column 34 is not squeezed, the elastic force of the elastic column 34 is utilized to cause the protrusion 35 to limit the arc groove 32 so that the hollow disk 31 cannot deflect, and the hollow disk 31 drives the pin 33 to always lift the slide groove 47, thereby reducing the downward pressure of the slip ring 42 on the elastic block 44, further ensuring that the elastic block 44 is stably contracted in the through groove to avoid interference with the placement of the reagent tube. At the same time, the design of the slide groove 47 ensures that when the positioning core tube 4 drives the slip ring 42 to rotate, there is sufficient room for movement.

[0028] Embodiment 5, on the basis of the above embodiment, a U-shaped slide 6 is slidably engaged with the inner wall of the installation groove, and wedge grooves 61 are provided at both ends of the U-shaped slide 6 close to the axis of the rotating worm gear table 2, and the wedge groove 61 has a second inclined surface movably abutting against the elastic column 34, and a second pin 62 is fixedly connected to the upper end of the U-shaped slide 6 away from the axis of the rotating worm gear table 2; A guide ring 11 is fixedly connected to the inner wall of the rotating worm gear table 2, and an annular groove 12 is provided at the bottom of the guide ring 11. The pin 62 is movably engaged in the annular groove 12. The annular groove 12 is composed of an outer ring segment on the left, an inner ring segment on the rear side and a middle ring segment on the right side, and an oblique groove transition is provided between each ring segment. The inner ring segment on the rear side is located below the filling mechanism 71.

[0029] During filling, as the rotating worm gear table 2 rotates, the U-shaped slide 6 is driven to rotate synchronously, and the pin 2 62 on the U-shaped slide 6 is engaged with different ring segments of the annular groove 12, thereby being driven to move radially relative to the rotating worm gear table 2. When the rotating worm gear table 2 rotates backward, the front U-shaped slide 6 connected to the outer ring segment is connected to the middle ring segment, and the U-shaped slide 6 uses the inclined surface 2 on the wedge groove 61 to squeeze the elastic column 34, and the elastic column 34 drives the protrusion 1 35 to squeeze the arc groove 32, thereby driving the hollow disk 31 to deflect, so that the pin 1 33 drives the slip ring 42 to move downward using the slide groove 47, and the suspension bar 43 drives the elastic resistance block 44 to move downward along the slope 46, squeezing the reagent tube and applying downward force to fix it, so that the reagent tube reaches the standard receiving position before filling.

[0030] Embodiment 6, on the basis of the above embodiment, the inner walls on both sides of the installation groove are slidably connected with elastic clamping blocks 5, the elastic clamping blocks 5 and the U-shaped slide 6 have hook parts that are interlocked with each other, the inner walls on both sides of the installation groove are provided with key grooves corresponding to the elastic clamping blocks 5, and a hinge rod 51 is movably connected between the elastic clamping blocks 5 and the lower outer wall of the sleeve 3.

[0031] Initially, each elastic clamping block 5 is movably clamped in the key slot at one side close to the adjacent U-shaped slide 6. When placing the reagent tube in the positioning core cylinder 4 from the front side, the U-shaped slide 6 just uses the hook part to buckle the hook part on the elastic clamping block 5, and the elastic clamping block 5 cannot move, so that the hinge rod 51 is used to keep the sleeve 3 in position, and the sleeve 3 will not swing when the reagent tube is placed; Subsequently, as the rotating worm gear table 2 rotates, the front U-shaped slide 6 connected to the outer ring segment is connected to the middle ring segment, and the U-shaped slide 6 squeezes the elastic column 34 and then moves toward the elastic block 5, but just abuts against the elastic block 5. During this period, the elastic block 44 continues to position the reagent tube. Subsequently, as the U-shaped slide 6 connected to the middle ring segment is connected to the inner ring segment, the U-shaped slide 6 squeezes the elastic block 5 and moves, and the elastic block 5 drives the hinge rod 51 to pull the sleeve 3 to deflect. Based on the coaxial nature of the elastic column 34 and the rotating axis of the sleeve 3, since the U-shaped slide 6 still squeezes the elastic column 34, when the sleeve 3 drives the reagent tube to deflect, the reagent tube is not affected and is still stably positioned by the elastic block 44, so it is safe and reliable to use.

[0032] Embodiment 7, on the basis of the above embodiment, a filling support 7 is fixedly connected to the left side of the top of the filling seat 1, a filling mechanism 71 is fixedly installed on the filling support 7, and an L-shaped driving rod 73 is slidably inserted in the front side of the filling support 7; The central tooth tube 21 is rotatably connected to the bottom of the inner cavity of the filling seat 1 , a spiral groove 22 is provided in the central tooth tube 21 , and a second protrusion 74 movably engaged with the spiral groove 22 is provided on the L-shaped driving rod 73 .

[0033] When the filling mechanism 71 controls the filling plug 72 to move up and down for filling, the L-shaped driving rod 73 is guided and stably driven by the filling plug 72 to move up and down by the filling plug 72. When the filling plug 72 drives the L-shaped driving rod 73 to move downward, the protrusion 74 is used to drive the spiral groove 22 to rotate the center tooth tube 21, thereby driving the torque tooth column 48 engaged with it to rotate and drive the reagent tube to rotate for filling.

[0034] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A nucleic acid extraction reagent filling device, comprising a filling seat (1), characterized in that: The inner cavity of the filling seat (1) is rotatably provided with a rotating worm gear platform (2), the middle part of the rotating worm gear platform (2) is rotatably connected to a central tooth tube (21), the outer periphery of the rotating worm gear platform (2) is provided with a circumferential array of mounting grooves, a sleeve (3) is rotatably connected in the mounting groove, a positioning core barrel (4) is rotatably connected in the sleeve (3), a sponge fixing ring (41) is fixedly connected to the inner cavity top of the positioning core barrel (4), a circumferential array of through grooves is provided on the side wall of the positioning core barrel (4), the through groove has a slope (46), an elastic stop block (44) is movably connected to the slope (46), a torsion tooth column (48) passing through the sleeve (3) is fixedly connected to the bottom of the positioning core barrel (4), a torsion spring is provided between the torsion tooth column (48) and the bottom of the sleeve (3), and the torsion tooth column (48) can mesh with the central tooth tube (21); A filling mechanism (71) is arranged on the top of the filling seat (1), a filling plug (72) is arranged on the filling mechanism (71), and an L-shaped driving rod (73) which is movably inserted into the central tooth tube (21) is fixedly sleeved on the filling plug (72).

2. A nucleic acid extraction reagent filling device according to claim 1, characterized in that: A driving worm (13) is rotatably connected to the rear wall of the inner cavity of the filling seat (1) and meshes with the rotating worm gear platform (2). The driving worm (13) is driven by a driving motor installed on the rear wall of the inner cavity of the filling seat (1).

3. A nucleic acid extraction reagent filling device according to claim 2, characterized in that: A slip ring (42) is slidably connected between the sleeve (3) and the positioning core tube (4); the inner wall of the slip ring (42) has a suspension bar (43) extending into the through groove; the suspension bar (43) movably passes through the slope (46); the elastic stop block (44) is slidably engaged with the bottom of the suspension bar (43); the elastic stop block (44) is elastically connected to the inner wall of the slip ring (42); there is an inclined surface abutting against each other between the elastic stop block (44) and the slope (46); and sliding grooves (47) are respectively provided on both sides of the slip ring (42).

4. A nucleic acid extraction reagent filling device according to claim 3, characterized in that: One end of the elastic stopper (44) away from the slope (46) is fixedly connected to a rubber friction pad (45).

5. A nucleic acid extraction reagent filling device according to claim 4, characterized in that: The inner wall of the sleeve (3) is rotatably connected to two symmetrical hollow disks (31), the inner wall of the hollow disk (31) is provided with an arc groove (32), the surface of the hollow disk (31) is fixedly connected to a pin column (33) that is movably engaged with the slide groove (47), the outer wall of the sleeve (3) is slidably engaged with an elastic column (34), the bottom of the elastic column (34) is provided with a protrusion (35) that is movably engaged with the arc groove (32), and the elastic column (34) is coaxial with the rotation axis of the sleeve (3).

6. A nucleic acid extraction reagent filling device according to claim 5, characterized in that: A U-shaped slide (6) is slidably engaged with the inner wall of the mounting groove, and wedge grooves (61) are provided at both ends of the U-shaped slide (6) close to the axis of the rotating worm gear platform (2), and the wedge groove (61) has a second inclined surface that movably abuts against the elastic column (34), and a second pin column (62) is fixedly connected to the upper end of the U-shaped slide (6) on a side away from the axis of the rotating worm gear platform (2); A guide ring (11) is fixedly connected to the inner wall of the rotating worm gear table (2), and an annular groove (12) is provided at the bottom of the guide ring (11). The second pin (62) is movably engaged with the annular groove (12). The annular groove (12) is composed of an outer ring segment on the left side, an inner ring segment on the rear side, and a middle ring segment on the right side, and oblique groove transitions are provided between the ring segments. The inner ring segment on the rear side is located below the filling mechanism (71).

7. A nucleic acid extraction reagent filling device according to claim 6, characterized in that: The inner walls on both sides of the installation groove are slidably connected with elastic clamping blocks (5), and the elastic clamping blocks (5) and the U-shaped slide frame (6) have hook parts that are interlocked. The inner walls on both sides of the installation groove are provided with key slots corresponding to the elastic clamping blocks (5), and a hinge rod (51) is movably connected between the elastic clamping blocks (5) and the lower outer wall of the sleeve (3).

8. A nucleic acid extraction reagent filling device according to claim 7, characterized in that: A filling support (7) is fixedly connected to the left side of the top of the filling seat (1); the filling mechanism (71) is fixedly mounted on the filling support (7); a telescopic filling gun is arranged at the bottom of the filling mechanism (71); and the L-shaped driving rod (73) is slidably plugged into the front side of the filling support (7); The central tooth tube (21) is rotatably connected to the bottom of the inner cavity of the filling seat (1), a spiral groove (22) is provided in the central tooth tube (21), and a second protrusion (74) movably engaged with the spiral groove (22) is provided on the L-shaped driving rod (73).

Images