Medicine stripping device for test

Abstract

The invention discloses a medicine stripping device for test, which comprises a needle rod, a channel, a pintle, a needle clamp seat, a needle clamp, a wooden needle and a rubber conical head, the needle rod is internally provided with a channel for replacing or withdrawing the needle, and the pintle is movably arranged in the channel; the needle clamp seat is arranged on the side face of the lower portion of the needle rod, the needle clamp is detachably arranged in the needle clamp seat, and the front end of the needle clamp is communicated with the channel. A wooden needle is stored in the needle clamp; the rubber conical head is arranged at the front end of the needle rod; the inner diameter of the channel is the same as the diameter of the wooden needle, and the inner diameter of the rubber conical head is 0.1 mm-0. 5mm smaller than the diameter of the wooden needle. The medicine stripping device is characterized in that the wooden needle in the medicine stripping device is designed in a bullet replacement mode, the used wooden needle is pushed out of the needle rod through the pintle to be replaced, and the wooden needle can be used for cutting aluminum foil and can be continuously replaced in a non-contact mode.

Description

Technical Field

[0001] The invention belongs to the technical field of medical instruments, and in particular relates to a drug stripper for experiments. Background Art

[0002] Clinical trials are an important means of evaluating the safety and effectiveness of drugs and an important basis for drug approval and marketing. Bioequivalence tests are key studies to evaluate the consistency of quality and efficacy between generic drugs and original research drugs. According to the "Annual Report on the Progress of Clinical Trials for New Drug Registration in China (2023)" issued by the National Center for Drug Evaluation, in 2023, clinical trials of new drugs accounted for 54%, and bioequivalence tests accounted for 46%. It can be seen that the number of bioequivalence tests still accounts for a high proportion. In bioequivalence tests, general oral solid preparations (such as tablets, capsules) and other dosage forms need to be prepared by researchers according to the drug randomization table, and then taken by the subjects. When researchers perform drug stripping operations, they need to avoid inaccurate dosage caused by tablet damage. When more tablets are damaged during drug stripping, the number of test drugs may be insufficient, which may cause the test to be unable to proceed normally. In addition, in order to ensure the reliability of test data, cross-contamination caused by operation should be avoided when stripping drugs.

[0003] At present, toothpicks and other auxiliary tools are often used or manual stripping is often performed during research. However, toothpicks are inconvenient to replace, stripping easily produces debris (aluminum foil debris), and there is cross contamination. This shows the importance of designing a stripper for bioequivalence testing to ensure the validity and reliability of test data and the smooth conduct of clinical trials. Summary of the invention

[0004] The present invention aims at solving the above-mentioned deficiencies in the prior art and invents a drug stripping device for testing.

[0005] In order to achieve the above object, the present invention adopts the following technical solution: A drug stripper for experiment, comprising a needle bar, a channel, a needle bolt, a needle clamp seat, a needle clamp, a wooden needle and a rubber conical head, wherein the needle bar is provided with a channel for replacing or withdrawing the needle, and the needle bolt is movably arranged in the channel; the needle clamp seat is arranged on the side of the lower part of the needle bar, and the needle clamp is detachably arranged in the needle clamp seat, and the front end of the needle clamp is connected with the channel; the wooden needle is stored in the needle clamp; the rubber conical head is arranged at the front end of the needle bar; the inner diameter of the channel is the same as the diameter of the wooden needle, and the inner diameter of the rubber conical head is 0.1mm~0.5mm smaller than the diameter of the wooden needle.

[0006] The innovation of the present invention is that the wooden needle in the medicine stripper is designed in a bullet replacement manner, and the used wooden needle is pushed out of the needle rod by the needle bolt for replacement, so that the aluminum foil can be cut and the wooden needle can be continuously replaced without contact.

[0007] Furthermore, it also includes an elastic rope, one end of which is arranged on the top of the needle bolt, and the other end of the elastic rope is connected to the top of the channel. The function of the elastic rope is to enable the needle bolt to automatically return to its initial position after moving downward, and maintain the initial position state after operation to facilitate further operation; when the needle bolt is in the initial position, it can block the wooden needle in the needle clamp from entering the channel.

[0008] Furthermore, under the constraint of elastic expansion and contraction, the lower end of the needle bolt is located in the middle of the needle clamp when in the initial position; the needle bolt can protrude the rubber cone head when it moves downward, and the function of the needle bolt is to insert and withdraw the wooden needle.

[0009] Furthermore, the inner cavity of the needle clamp is a cavity that is small in the front and large in the back and has a downwardly inclined bottom. The front of the cavity is small to ensure that the needles can only be pushed out one by one, and the back of the cavity is large to store more wooden needles. The bottom of the cavity is inclined so that the wooden needles can move out of the needle clamp according to the inertia of gravity.

[0010] Furthermore, the diameter of the wooden needle is 1.0 mm to 2.0 mm, and the wooden needle can be replaced by a toothpick.

[0011] Furthermore, the needle rod is provided with a marking groove for marking the up and down movement position of the needle bolt, and there are 4 marking grooves, which are, from top to bottom, the return needle groove, the initial groove, the lower needle groove and the withdrawal needle groove. When the hand-pushing part of the needle bolt moves to the return needle groove, the needle bolt will not block the front of the needle clamp, and the wooden needle inside it can enter the channel. When the hand-pushing part of the needle bolt moves to the initial groove, the needle bolt blocks the front of the needle clamp, and the wooden needle inside it cannot enter the channel. When the hand-pushing part of the needle bolt moves to the lower needle groove, the needle bolt will push the wooden needle in the channel and get it stuck in the rubber cone head. When the hand-pushing part of the needle bolt moves to the withdrawal needle groove, the needle bolt will push out the wooden needle stuck in the rubber cone head for replacement.

[0012] Furthermore, it also includes a ball. The inner side of the hand-pushing part of the needle bolt is provided with a ball used in conjunction with the marked groove. The ball is used to let the user know whether the needle bolt has moved into place when the needle bolt is stuck when moving to a certain marked groove, and also provides a buffering effect when the needle bolt rises from the bottom.

[0013] Furthermore, it also includes a battery compartment, a fan and a switch. The top of the needle rod is provided with a battery compartment, the top of the battery compartment is provided with a fan, and the switch is provided on the side of the battery compartment. The fan can blow away small debris generated by drug packaging or debris generated by cutting aluminum foil.

[0014] The advantages of the present invention are: 1. The device stores wooden needles for cutting aluminum foil in the needle rod and can be replaced continuously without contact. The wooden needles are used to peel the oral solid preparations from the medicine plate, which largely avoids damage to the tablets (grains); 2. During the operation, the operator can replace new wooden needles without contact according to the different tablets to be packaged, which not only avoids cross contamination but also saves time; 3. It solves the packaging problem of oral solid preparations in current bioequivalence tests. The force is easy to control when peeling the tablets, which can ensure the integrity of the tablets. It is suitable for medicines of various shapes and lengths packaged in aluminum foil. When peeling the medicine, contamination between different medicines can be avoided, and the efficiency of the operator is greatly improved; 4. The overall design is pure structure, and the processing technology is simple. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a three-dimensional diagram of a drug stripper for testing of the present invention; Figure 2 It is a left side view of a drug stripper for testing of the present invention; Figure 3 It is a centerline cross-sectional view of a drug stripper for testing of the present invention; Figure 4 It is a three-dimensional diagram of a middle needle plug of a drug stripper for testing of the present invention; Figure 5 The present invention is a stereoscopic diagram of a middle needle clamp of a drug stripping device for testing. DETAILED DESCRIPTION

[0016] The present invention is described in detail below with reference to the accompanying drawings: In the description of the present invention, it should be noted that the directions or positional relationships indicated by "upper", "lower", "front" and "back" etc. are based on the directions or positional relationships shown in the accompanying drawings, or are the directions or positional relationships in which the inventive product is usually placed when in use. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, and a specific direction structure and operation, and therefore cannot be understood as a limitation on the present invention.

[0017] like Figure 1-5As shown, a drug stripping device for testing comprises a needle bar 1, a channel 2, a needle bolt 3, a needle clamp seat 4, a needle clamp 5, a wooden needle 6, a rubber cone head 7 and an elastic rope 8. The needle bar 1 is provided with a channel 2 for replacing or withdrawing the needle, and the needle bolt 3 is movably arranged in the channel 2. The needle bolt 3 is composed of a bolt rod 31, a connecting portion 32 and a hand-pushing portion 33. The bolt rod 31 is slidably arranged in the channel 2; the hand-pushing portion 33 is connected to the top of the bolt rod 31 through the connecting portion 32, and the hand-pushing portion 33 is slidably arranged on the side of the needle bar 1; and the needle bar 1 is provided with a clearance groove for avoiding the air connection portion 32. The needle clamp seat 4 is arranged on the side of the lower part of the needle bar 1, and is 2.0 mm to 5.0 mm away from the bottom of the needle bar 1. The diameter of the bolt rod 31 is the same as the inner diameter of the channel 2, and the inner diameter of the channel 2 is the same as the diameter of the wooden needle 6.

[0018] The needle clamp 5 is detachably arranged in the needle clamp seat 4, and the needle clamp 5 is installed like a magazine of a gun. A wooden needle 6 with a diameter of 1.0mm~2.0mm is stored in the needle clamp 5, and the front end of the needle clamp 5 is connected with the channel 2, so that the wooden needle 6 in the needle clamp 5 can smoothly enter the channel 2; the inner cavity of the needle clamp 5 is a cavity with a small front and a large back and a bottom inclined downward, and the width of the front end of the inner cavity (left as the front) is slightly larger than the diameter of the wooden needle 6, ensuring that only a single needle can enter; the rear end of the inner cavity is a storage part for storing as many wooden needles 6 as possible; its bottom is inclined so that the wooden needles 6 inside can move downward and enter the narrow opening of the front end in sequence.

[0019] The rubber cone head 7 is arranged at the front end of the needle rod 1, and the inner diameter of the rubber cone head 7 is 0.1mm~0.5mm smaller than the diameter of the wooden needle 6, so as to ensure that the wooden needle 6 can remain in the channel 2 after entering it. At the same time, the wooden needle 6 located at this position has an overlapping area with the needle clamp 5 in the vertical position, which can limit the wooden needle 6 inside the needle clamp 5 from running out, and ensure that there is only one wooden needle 6 in the channel 2 at all times. The wooden needle 6 in the channel 2 can only protrude the rubber cone head 7 by pushing out the needle bolt 3. In the absence of the needle bolt 3, the wooden needle 6 will be firmly clamped and fixed by the rubber cone head 7. The clamping force of the wooden needle 6 is sufficient to cut the aluminum foil without loosening. When the wooden needle 6 needs to be replaced, the wooden needle 6 can be withdrawn by pressing the needle bolt 3 to the bottom position.

[0020] In order to make the pintle 3 reset automatically, an elastic rope 8 is arranged at the top of the pintle 3 and the channel 2, one end of the elastic rope 8 is arranged at the top of the pintle 3, and the other end of the elastic rope 8 is connected to the top of the channel 2. When the pintle 3 is located below the initial position, it can automatically reset under the action of the elastic rope 8. Under the constraint of the elastic expansion 8, when the pintle 3 is in the initial position, its lower end is located in the middle position of the needle clamp 5, so that the wooden needle 6 can be blocked from coming out of the needle clamp 5; the pintle 3 moves downward (to the bottom position) to protrude the rubber cone head 7, ensuring that the used wooden needle 6 can be completely withdrawn without additional operation.

[0021] In order to identify the position of the pintle 3 during the movement, a marking groove 9 for marking the up and down movement position of the pintle 3 is provided on the pintle 1, and a ball 10 for use with the marking groove 9 is also provided. The ball 10 is arranged on the inner side of the hand-pushing portion 33 of the pintle 3. Whenever the hand-pushing portion 33 of the pintle 3 moves to the corresponding marking groove 9, it will stop for a while, so as to judge whether the pintle 3 has moved to the appropriate position. The marked grooves 9 are provided with 4 grooves, which are respectively a return needle groove, an initial groove, a lower needle groove and a withdrawal needle groove from top to bottom. When the hand-pushing portion 33 of the needle bolt 3 moves to the return needle groove (the topmost position), the front end of the needle bolt 3 will not block the front of the needle clamp 5, and the wooden needle 6 therein can enter the channel 2; when the hand-pushing portion 33 of the needle bolt 3 moves to the initial groove, the needle bolt 3 blocks the front of the needle clamp, and the wooden needle therein cannot enter the channel; when the hand-pushing portion 33 of the needle bolt 3 moves to the lower needle groove, the needle bolt 3 will push out the wooden needle 6 located in the channel 2 and clamp it in the rubber cone head 7, completing the needle removal operation; when the hand-pushing portion 33 of the needle bolt 3 moves to the withdrawal needle groove, the needle bolt 3 will push out the wooden needle 6 stuck in the rubber cone head 7 and replace it, completing the withdrawal needle operation.

[0022] In order to clean the debris generated when packaging or cutting aluminum foil, a battery compartment 11, a fan 12 and a switch 13 are also provided. The battery compartment 11 is provided on the top of the needle bar 1, the fan 12 is provided on the top of the battery compartment 11, and the switch 13 is provided on the side of the battery compartment 11. When the debris needs to be cleaned, the needle bar 1 only needs to be turned upside down and the switch 13 can be turned on to blow away the debris with the fan 12.

[0023] Although the specific embodiments of the present invention have been described and illustrated in detail above, it should be noted that various changes and modifications may be made to the above embodiments without departing from the spirit of the present invention and the scope of the appended claims.

Claims

1. A drug stripper for testing, characterized in that: The needle bar (1) comprises a needle rod (1), a channel (2), a needle bolt (3), a needle clamp seat (4), a needle clamp (5), a wooden needle (6) and a rubber cone head (7); the needle rod (1) is provided with a channel (2) for replacing or withdrawing the needle, and the needle bolt (3) is movably arranged in the channel (2); the needle clamp seat (4) is arranged on the side of the lower part of the needle rod (1); the needle clamp (5) is detachably arranged in the needle clamp seat (4), and the front end of the needle clamp (5) is connected to the channel (2); the wooden needle (6) is stored in the needle clamp (5); the rubber cone head (7) is arranged at the front end of the needle rod (1); the inner diameter of the channel (2) is the same as the diameter of the wooden needle (6), and the inner diameter of the rubber cone head (7) is 0.1 mm to 0.5 mm smaller than the diameter of the wooden needle (6).

2. A drug stripping device for testing according to claim 1, characterized in that: It also comprises an elastic rope (8), one end of which is arranged on the top of the pintle (3), and the other end of which is connected to the top of the channel (2).

3. The drug stripping device for testing according to claim 2, characterized in that: Under the constraint of the elastic expansion (8), the lower end of the needle bolt (3) is located at the middle position of the needle clamp (5) when it is in the initial position; the needle bolt (3) moves downward to protrude the rubber cone head (7).

4. The drug stripping device for testing according to claim 3, characterized in that: The inner cavity of the needle clamp (5) is a cavity that is small at the front and large at the back, and has a bottom that is inclined downward.

5. The drug stripping device for testing according to claim 4, characterized in that: The diameter of the wooden needle (6) is 1.0 mm to 2.0 mm.

6. The drug stripping device for testing according to claim 5, characterized in that: The needle rod (1) is provided with a marking groove (9) for marking the upward and downward movement position of the needle bolt (3).

7. The drug stripping device for testing according to claim 6, characterized in that: It also comprises a rolling ball (10), and the inner side of the hand-pushing portion of the pintle (3) is provided with a rolling ball (10) for use in conjunction with the marked groove (9).

8. A drug stripping device for testing according to any one of claims 1 to 7, characterized in that: It also comprises a battery compartment (11), a fan (12) and a switch (13); the battery compartment (11) is arranged on the top of the needle rod (1), the fan (12) is arranged on the top of the battery compartment (11), and the switch (13) is arranged on the side of the battery compartment (11).

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