Liquid chromatographic column convenient to connect

Abstract

The invention discloses a convenient-to-connect liquid chromatographic column, which comprises a liquid chromatographic column, one side of the liquid chromatographic column is provided with a column end interface, one side of the column end interface is provided with a composite sealing structure, one side of the composite sealing structure is provided with a pipeline interface, the center of a sealing groove is provided with a communicating pipeline, and the communicating pipeline is communicated with the sealing groove. A guide pin is arranged on one side of the outer wall of the sealing groove, a locking mechanism is arranged on one side of the guide pin, a wave spring is arranged on one side of the composite sealing structure, the composite sealing structure is connected with the pipeline connector through the wave spring, and a rotary buckle is arranged on one side of the outer wall of the pipeline connector. The column end connector and the pipeline connector are locked through the combination of the rotary buckle and the locking mechanism, through the design, the connecting time is shortened to 5-8 seconds, 60 MPa working pressure can be borne, I P67-level sealing is still kept after 2000 times of plugging and unplugging tests, and meanwhile the operation error rate is greatly reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of liquid chromatography analysis, and more particularly to a conveniently connected liquid chromatography column. Background Art

[0002] Liquid chromatography separation technology is used to effectively separate mixed samples with multiple components, and the core component is the liquid chromatography separation column. The separation principle is to dissolve the mixed component sample in a mobile phase, and the mobile phase flows through the chromatographic filler filled in the chromatographic column at a certain flow rate under a relatively high pressure. Due to the different adsorption forces of the chromatographic filler on different components, different components will flow through the chromatographic filler at different flow rates, and the time when different components flow out of the chromatographic column and the content of each component are detected in the detector of the liquid chromatograph, thereby achieving the purpose of separation and detection. The existing liquid chromatography column has the following technical defects in terms of pipeline connection:

[0003] The traditional threaded connection method is cumbersome to operate and requires multiple rotations to tighten. The installation takes about 3 to 5 minutes. The sealing structure adopts a single O-ring design, which is prone to sealing failure after frequent disassembly. In addition, the connection parts are difficult to align, and micro-leakage is easy to occur for novice operators. At the same time, the sealing performance is significantly reduced under high temperature and high pressure environments (working pressure>40MPa).

[0004] Therefore, a liquid chromatography column that is convenient to connect is proposed to address the above problems. Summary of the invention

[0005] In order to overcome the above defects of the prior art, the present invention provides a liquid chromatography column that is convenient to connect to solve the problems raised in the above background technology.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a liquid chromatography column that is easy to connect, comprising a liquid chromatography column, a column end interface is provided on one side of the liquid chromatography column, a composite sealing structure is provided on one side of the column end interface, a pipeline interface is provided on one side of the composite sealing structure, the column end interface comprises a sealing groove, a connecting pipeline, a guide pin and a locking mechanism, a connecting pipeline is provided at the center of the sealing groove, a guide pin is provided on one side of the outer wall of the sealing groove, a locking mechanism is provided on one side of the guide pin, a wave spring is provided on one side of the composite sealing structure, and the composite sealing structure is connected to the pipeline interface through the wave spring, a rotating buckle is provided on one side of the outer wall of the pipeline interface, and the rotating buckle locks the column end interface and the pipeline interface by combining with the locking mechanism.

[0007] Preferably, a color code positioning point is provided on one side of the outer wall of the column end interface and the pipeline interface, and a one-way spiral groove is provided on one side of the sealing groove, and a spiral guide groove is provided on one side of the inner wall of the pipeline interface. The column end interface is combined with the pipeline interface by aligning the color code positioning points of the column end interface and the pipeline interface, and rotating the spiral guide groove clockwise to connect with the one-way spiral groove.

[0008] Preferably, the composite sealing structure includes a V-ring, a sealing wedge pad and a dust ring, one side of the wave spring is fixedly connected to the inside of the sealing groove, the other side of the wave spring is provided with a V-ring, one side of the V-ring is provided with a sealing wedge pad, and one side of the sealing wedge pad is provided with a dust ring, and by combining the column end interface and the pipeline interface, the dust ring drives the V-ring and the sealing wedge pad to displace, thereby compressing the wave spring.

[0009] Preferably, a titanium alloy torsion spring is provided inside the pipeline interface, a sealing pressure ring is provided on one side of the titanium alloy torsion spring, the sealing pressure ring has the same cross-sectional size as the dust ring, a fixing bolt is provided on one side of the sealing pressure ring, a guide groove is provided on one side of the fixing bolt, and the guide pin is connected by rotating clockwise along the column end interface through the pipeline interface, thereby being combined with the guide groove.

[0010] Preferably, a visual indication window is provided on one side of the outer wall of the composite sealing structure, an indication window dust ring is provided on one side of the visual indication window, and the visual indication window is connected to the pipeline interface through the indication window dust ring.

[0011] Preferably, the locking mechanism includes a limiting boss, a slot, a limiting rod, a telescopic spring and an indicator mark, a slot is provided on one side of the limiting boss, a limiting rod is provided inside the slot, a protruding block is provided on the outer wall of the limiting rod, one side of the limiting rod is connected to the inner wall of the limiting boss through a rotating shaft, a telescopic spring is provided on the other side of the limiting rod, and an indicator mark is provided on the top of the limiting boss.

[0012] Preferably, the connecting surface of the rotating buckle is provided with a groove, and the pipeline interface and the column end interface are locked by combining with the limit rod. After the column end interface and the pipeline interface are locked by the locking mechanism and the rotating buckle, the rotating buckle is moved forward by continuing to rotate, driving the limit rod to move, and the protruding block is separated from the rotating buckle by the telescopic spring, so that the rotating buckle rotates counterclockwise to disengage from the slot to release the lock.

[0013] Preferably, a temperature sensor is provided on one side of the internal pipe of the pipeline interface, a ground terminal is provided on one side of the temperature sensor, and an insulating gasket is provided on one side of the temperature sensor and the ground terminal, and the center of the insulating gasket is combined with the pipeline of the pipeline interface.

[0014] Technical effects and advantages of the present invention:

[0015] 1. Compared with the prior art, this conveniently connected liquid chromatography column adopts a 60° rotating snap-on connection mechanism, is provided with a limiting boss and an elastic locking tongue, and the guide groove design includes a 30° conical guide section and a plane positioning section. At the same time, a visual docking indication window is provided, which shortens the connection time to 5 to 8 seconds and can withstand a working pressure of 60MPa. Compared with the traditional method, the efficiency is improved.

[0016] 2. Compared with the prior art, this conveniently connected liquid chromatography column adopts a three-level sealing structure combination, namely a main seal, a secondary seal and a dust ring, and a conical-plane composite sealing surface is set at the same time, and a built-in pressure adaptive compensation mechanism, so that the device can still maintain IP67 level sealing after 2000 plug-in and pull-out tests.

[0017] 3. Compared with the prior art, this conveniently connected liquid chromatography column is securely locked through the dual safety of a mechanical rotary lock and an elastic snap buckle, and is equipped with a variety of connection operation instructions to effectively reduce the rate of operational errors. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is an exploded schematic diagram of the overall three-dimensional structure of the present invention.

[0019] Figure 2 It is a schematic diagram of the cross-sectional structure of the column end interface of the present invention.

[0020] Figure 3 It is a schematic diagram of the three-dimensional structure of the pipeline interface of the present invention.

[0021] Figure 4 It is a schematic diagram of the combined structure of the column end interface and the pipeline interface of the present invention.

[0022] Figure 5 It is a schematic diagram of the cross-sectional structure of the visual indication window of the present invention.

[0023] Figure 6 It is a schematic diagram of the side structure of the pipeline interface of the present invention.

[0024] Figure 7 It is a schematic diagram of the internal three-dimensional structure of the slot of the locking mechanism of the present invention.

[0025] The accompanying drawings are marked as follows: 1. liquid chromatography column; 2. column end interface; 201. sealing groove; 202. connecting pipeline; 203. guide pin; 204. locking mechanism; 2041. limiting boss; 2042. slotting; 2043. limiting rod; 20431. raised block; 2044. telescopic spring; 2045. indication mark; 3. composite sealing structure; 301. V-ring; 302. sealing wedge pad; 303. dust ring; 4. pipeline interface; 5. wave spring; 6. rotating buckle; 7. color code positioning point; 8. one-way spiral groove; 9. spiral guide groove; 10. titanium alloy torsion spring; 11. sealing pressure ring; 12. fixing bolt; 13. guide groove; 14. visual indication window; 15. indication window dust ring; 16. temperature sensor; 17. grounding terminal; 18. insulating gasket; 19. identification plate. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Example 1

[0028] As attached Figures 1 to 7 A liquid chromatography column for easy connection is shown, comprising a liquid chromatography column 1, a column end interface 2 is provided on one side of the liquid chromatography column 1, a composite sealing structure 3 is provided on one side of the column end interface 2, a pipeline interface 4 is provided on one side of the composite sealing structure 3, the column end interface 2 comprises a sealing groove 201, a connecting pipeline 202, a guide pin 203 and a locking mechanism 204, a connecting pipeline 202 is provided at the center of the sealing groove 201, a guide pin 203 is provided on one side of the outer wall of the sealing groove 201, a locking mechanism 204 is provided on one side of the guide pin 203, a wave spring 5 is provided on one side of the composite sealing structure 3, and the composite sealing structure 3 is connected to the pipeline interface 4 through the wave spring 5, a rotating buckle 6 is provided on one side of the outer wall of the pipeline interface 4, and the rotating buckle 6 is combined with the locking mechanism 204 to lock the column end interface 2 and the pipeline interface 4.

[0029] In a specific embodiment, the guide pin 203 of the column end interface 2 is made of zirconia ceramic material and is precisely machined. Its front end is designed as a 30° conical structure, forming a three-dimensional self-alignment guide system with the spiral guide groove 9 on the inner wall of the pipeline interface 4. When inserted axially, the guide pin 203 automatically corrects the coaxial deviation through the conical contact, and the tolerance is controlled within ±0.01mm; the locking mechanism 204 includes a double insurance structure of a titanium alloy rotating buckle 6 and a limit rod 2043. When operating, it rotates 60° clockwise, and the buckle 6 slides along the plane positioning section of the guide groove 13, compressing the wave spring 5 to generate 8-10N· m locking torque, and at the same time, the elastic limit rod 2043 automatically pops out and snaps into the limit groove when the pressure reaches 0.5MPa, forming an irreversible mechanical lock; the composite sealing structure 3 adopts a graded sealing design, which is composed of a scraper ring 303, a PTFE sealing wedge pad 302 and a V-ring 301 made of FFKM material from the outside to the inside, wherein the 15° conical surface of the V-ring 301 and the plane of the sealing groove 201 form the main sealing surface, and the wave spring 5 continuously compensates for the deformation of the seal through a pre-compression amount of 1.5mm, and combines the plasma surface treatment technology to reduce the sealing surface energy level to below 18dyn / cm, realizing dynamic pressure adaptation;

[0030] The technical effects of this design are as follows: the three-dimensional self-alignment mechanism of the guide pin 203 and the spiral guide groove 9 shortens the plugging and unplugging operation time to 5 to 8 seconds, which is 20 times more efficient than the traditional threaded connection; the three-level composite sealing structure 3 uses the gradient sealing principle to grade particle interception, low-pressure pre-seal and high-pressure main seal, and the leakage rate is ≤1×10 at a pressure of 60MPa. -9 Pa·m 3 / s, which is 50% higher than the pressure resistance of a single O-ring seal. The locking mechanism 204 improves the reliability of the connection, and the IP67 protection level is still maintained after multiple plug-in and pull-out tests. The dynamic compensation capability of the wave spring 5 can offset the thermal expansion displacement of ±0.3mm, and maintain a constant sealing pressure ratio under working conditions of -20℃ to 150℃. Together with the visual indicator window 14, intuitive judgment of the connection status and fool-proof operation can be achieved.

[0031] Example 2

[0032] Based on Example 1, the solution in Example 1 is further detailed in combination with the following specific working method. Figures 1 to 7 As shown, see the following description for details:

[0033] As a preferred embodiment, a color code positioning point 7 is provided on one side of the outer wall of the column end interface 2 and the pipeline interface 4, and a one-way spiral groove 8 is provided on one side of the sealing groove 201, and a spiral guide groove 9 is provided on one side of the inner wall of the pipeline interface 4. The column end interface 2 is combined with the pipeline interface 4 by aligning the color code positioning points 7 of the column end interface 2 and the pipeline interface 4, and rotating the spiral guide groove 9 clockwise to connect with the one-way spiral groove 8.

[0034] In a specific embodiment, the color mark positioning point 7 is a high-contrast red and green double-color logo, which is printed at the 12 o'clock position on the outer wall of the column end interface 2 and the pipe interface 4 respectively. The consistency of the initial assembly angle is ensured by visual alignment, and the error is controlled within ±1°; the unidirectional spiral groove 8 is designed as a progressive inclined surface structure with a 60° rotation stroke, and a 30° conical guide section is set at its starting end to form an asymmetric matching relationship with the spiral guide groove 9 on the inner wall of the pipe interface 4. The groove depth of the spiral guide groove 9 is 1.2mm, and the width tolerance is controlled within ±1°. At the H7 / g6 level, ensure that the guide pin 203 is evenly stressed during the rotation process; during operation, first align the color mark positioning point 7, apply 5-8N insertion force axially to make the guide pin 203 enter the guide section of the spiral guide groove 9, then rotate 60° clockwise, the guide pin 203 slides along the inclined surface of the one-way spiral groove 8, and at the same time compresses the wave spring 5 to generate a locking torque of 8-10N·m, until it rotates to the position of the limit boss 2041 and emits a "click" sound feedback, at which time the limit rod 2043 automatically pops out to complete the secondary locking;

[0035] The technical effects of this design are as follows: the visual guidance mechanism of the color-coded positioning point 7 enables operators to quickly master the connection method without professional training, and the assembly time is shortened to less than 5 seconds, which is 15 times more efficient than traditional threaded connections; the asymmetric design of the one-way spiral groove 8 and the spiral guide groove 9 combined with the 30° conical guide section effectively prevents mis-insertion and reverse rotation operations, reducing the error rate by 95%; the progressive bevel structure allows the seal to be evenly stressed during rotation, avoiding seal failure caused by local stress concentration, and combined with the dynamic compensation capability of the wave spring 5, the uniformity of the contact pressure distribution on the sealing surface is improved by 40%, and stable sealing performance can be maintained under a working pressure of 60MPa; the dual locking design of the mechanical limit boss and the elastic lock tongue ensures connection reliability, and the IP67 protection level can still be maintained after 2000 plug-in and pull-out tests. At the same time, the "click" sound feedback during rotation provides intuitive operation confirmation, further enhancing the user experience.

[0036] As a preferred embodiment, the composite sealing structure 3 includes a V-ring 301, a sealing wedge pad 302 and a dust ring 303. One side of the wave spring 5 is fixedly connected to the inside of the sealing groove 201, and the other side of the wave spring 5 is provided with a V-ring 301, one side of the V-ring 301 is provided with a sealing wedge pad 302, and one side of the sealing wedge pad 302 is provided with a dust ring 303. By combining the column end interface 2 and the pipeline interface 4, the dust ring 303 drives the V-ring 301 and the sealing wedge pad 302 to move, thereby compressing the wave spring 5.

[0037] In a specific embodiment, the V-ring 301 is made of perfluoroether rubber FFKM material, and its 15° conical surface forms the main sealing surface with the plane of the sealing groove 201, and the Shore hardness is controlled at 70±5, ensuring that the deformation accuracy can be maintained within 0.01mm under a pressure of 60MPa; the sealing wedge pad 302 is made of polytetrafluoroethylene PTFE material, and its wedge angle is designed to be 20°. The secondary seal is achieved by pre-compression of 15%, and a sealing capacity of at least 10MPa can be provided when the main seal fails; the dust ring 303 is made of graphite-filled fluororubber material, and its outer diameter It forms a 0.05mm interference fit with the inner wall of the pipeline interface 4, and can effectively remove impurities on the pipeline end face during the axial insertion process; the wave spring 5 is made of SUS304 stainless steel, the initial compression amount is set to 1.5mm, the spring stiffness coefficient is 8N / mm, and can dynamically compensate for the thermal expansion displacement of ±0.3mm; during assembly, the dust ring 303 first contacts the end face of the pipeline interface 4 and removes surface contaminants, and then the wedge surface of the sealing wedge pad 302 gradually fits with the conical surface of the V-ring 301, and the wave spring 5 is compressed to the working state, providing a continuous axial sealing force of 8-10N;

[0038] The technical effect of this design is reflected in the following aspects: the composite sealing structure 3 composed of three-stage sealing realizes graded protection through the gradient sealing principle; the dust ring 303 can intercept more than 95% of particles; the sealing wedge pad 302 provides low-pressure pre-sealing; the V-ring 301 assumes the main sealing function, which improves the overall sealing performance by 60% compared with the traditional single-stage sealing; the dynamic compensation ability of the wave spring 5 can adapt to the temperature change from -20℃ to 150℃, and the elastic deformation characteristics of the V-ring 301 can improve the uniformity of the contact pressure of the sealing surface by 40%, and the leakage rate is ≤1×10 at a pressure of 60MPa. -9 Pa·m 3 / s; The interference fit design of the dust ring 303 effectively extends the service life of the main seal. After testing, it can withstand 2000 plug-in and pull-out operations while still maintaining the IP67 protection level, while reducing the maintenance frequency by 90%; The 15° conical surface design of the V-ring 301 combined with the preload control of the wave spring 5 enables the connection to maintain a stable seal under vibration conditions, and the vibration resistance is significantly improved compared to the traditional structure.

[0039] As a preferred embodiment, a titanium alloy torsion spring 10 is provided inside the pipeline interface 4, a sealing pressure ring 11 is provided on one side of the titanium alloy torsion spring 10, the cross-sectional size of the sealing pressure ring 11 is consistent with that of the dust ring 303, a fixing bolt 12 is provided on one side of the sealing pressure ring 11, a guide groove 13 is provided on one side of the fixing bolt 12, and the guide pin 203 is connected by rotating clockwise along the column end interface 2 through the pipeline interface 4, thereby combining with the guide groove 13.

[0040] In a specific embodiment, the titanium alloy torsion spring 10 is made of Ti-6Al-4V material and is precisely wound. Its torsion angle is designed to be 120°, which can provide a constant torque output of 8-10N·m, ensuring the locking force stability of the rotating buckle 6 within a 60° stroke; the cross-sectional dimension tolerance of the sealing pressure ring 11 and the dust ring 303 is controlled within ±0.01mm, and 316L stainless steel material is electrolytically polished. Its inner wall forms a 15° cone with the V-ring 301, and the outer wall maintains a 0.02mm gap with the inner cavity of the pipeline interface 4 to ensure smooth axial movement; the fixing bolt 12 is made of A2-70 stainless steel, and the threaded part is coated with Loctite 243 thread locking glue is tightened with a torque of 5N·m to prevent loosening under vibration conditions; the guide groove 13 is designed as a progressive spiral structure, with a 30° conical guide section set at the starting end, a groove depth of 1.2mm, and a width tolerance controlled at H7 / g6 level, forming a precise match with the guide pin 203; during operation, the guide pin 203 slides in along the conical guide section of the guide groove 13, and then rotates 60° clockwise, and the titanium alloy torsion spring 10 gradually releases the pre-tightening torque, driving the sealing pressure ring 11 to axially move the compressed wave spring 5 until it rotates to the limit boss 2041 to complete the locking;

[0041] The technical effects of this design are reflected in: the high elastic modulus (110GPa) and fatigue resistance of the titanium alloy torsion spring 10 improve the locking torque stability by 40%, and the torque attenuation is ≤2% after 5000 cycle tests; the precise size control of the sealing pressure ring 11 combined with the 15° conical surface design improves the uniformity of the sealing surface contact pressure distribution by 50%, and the sealing performance is stable under a pressure of 60MPa; the anti-loosening design of the fixing bolt 12 improves the reliability of the connector under vibration conditions by 90%, and there is no loosening after a 10g vibration acceleration test; the progressive spiral structure of the guide groove 13 combined with the 30° conical guide section shortens the plug-in and pull-out operation time to less than 5 seconds, which is 15 times more efficient than traditional threaded connections. At the same time, it prevents damage to the seal caused by misoperation and extends the service life to more than 2000 plug-ins and pull-outs.

[0042] As a preferred embodiment, a visual indication window 14 is provided on one side of the outer wall of the composite sealing structure 3 , and an indication window dust ring 15 is provided on one side of the visual indication window 14 , and the visual indication window 14 is connected to the pipeline interface 4 through the indication window dust ring 15 .

[0043] In a specific embodiment, the visual indication window 14 is injection molded with high-strength polycarbonate material, the window thickness is 2mm, the light transmittance is ≥90%, and it can be clearly identified in a dim environment; the indication window dust ring 15 is made of silicone rubber material, the Shore hardness is 50±5, and forms a 0.05mm interference fit with the inner wall of the pipeline interface 4, ensuring that the IP67 protection level can still be maintained under a pressure of 60MPa; the visual indication window 14 is bonded and fixed to the pipeline interface 4 by UV curing glue, and the indication window dust ring 15 provides secondary sealing protection to prevent moisture from invading and affecting the operation of internal parts; during assembly, the indication window dust ring 15 is first pressed into the annular groove of the pipeline interface 4, and then the visual indication window 14 is aligned with the installation position, and a pre-tightening force of 5N is applied and UV curing is performed for 60 seconds to complete the fixation;

[0044] The technical effects of this design are reflected in: the visual indicator window 14 increases the accuracy of connection status judgment to 100%, and operators can quickly master the use method without professional training; the silicone rubber material selection of the indicator window dust ring 15 combined with the 0.05mm interference fit design improves the sealing performance by 30% compared with the traditional O-ring, and maintains a stable seal in the temperature range of -20°C to 150°C; the UV curing process ensures that the connection strength between the visual indicator window 14 and the pipeline interface 4 is ≥10MPa, and there is no falling off after 2000 plug-in tests; the high light transmittance and chemical corrosion resistance of the polycarbonate material enable the indicator window to remain clearly visible after long-term use, and the service life is extended to more than 5000 operations, while reducing 90% of maintenance requirements.

[0045] As a preferred embodiment, the locking mechanism 204 includes a limiting boss 2041, a slot 2042, a limiting rod 2043, a telescopic spring 2044 and an indication mark 2045. A slot 2042 is provided on one side of the limiting boss 2041, a limiting rod 2043 is provided inside the slot 2042, a protruding block 20431 is provided on the outer wall of the limiting rod 2043, one side of the limiting rod 2043 is connected to the inner wall of the limiting boss 2041 through a rotating shaft, a telescopic spring 2044 is provided on the other side of the limiting rod 2043, and an indication mark 2045 is provided on the top of the limiting boss 2041.

[0046] In a specific embodiment, the limiting boss 2041 is made of 316L stainless steel and is precisely machined. The surface of the limiting boss 2041 is designed with a 60° arc groove 2042, the groove depth is 1.5mm, and the width tolerance is controlled at ±0.01mm, which forms a precise match with the raised block 20431 of the limiting rod 2043; the limiting rod 2043 is connected to the inner wall of the limiting boss 2041 through a rotating shaft, and the rotation angle is designed to be 30°. The raised block 20431 on the outer wall is treated with tungsten carbide coating, and the hardness reaches HRA90 or above, ensuring that the wear amount is ≤0.02mm after 5000 operations; the telescopic spring 2044 is made of SUS304 stainless steel, and the telescopic spring The stiffness coefficient of the spring 2044 is 5N / mm, and the initial compression amount is set to 2mm, which can provide a continuous restoring elastic force of 3-5N; the indicator mark 2045 is engraved on the top of the limiting boss 2041 by laser engraving technology, including the dual-state marks of "LOCK" and "UNLOCK", and cooperates with the visual indicator window 14 to realize dual-state confirmation; during operation, the rotating buckle 6 drives the limiting rod 2043 to slide along the slot 2042, and when it is rotated to the 60° position, the protruding block 20431 contacts the mechanical stop point of the limiting boss 2041, and the telescopic spring 2044 is compressed to the working state, and the indicator mark 2045 displays the "LOCK" state;

[0047] The technical effects of this design are reflected in: the precise cooperation between the limit boss 2041 and the limit rod 2043 enables the rotation angle control accuracy to reach ±0.5°, which is 50% higher than the accuracy of the traditional locking mechanism; the tungsten carbide coated raised block 20431 improves the wear resistance by 80%, and has been tested to withstand more than 10,000 operation cycles; the preload design of the telescopic spring 2044 combined with the 30° rotation angle limit makes the locking operation feel clear, and the operating force is controlled within the range of 3-5N, which is 40% lower than the traditional structure; the combined design of the dual-state indicator mark 2045 and the visual indicator window 14 increases the accuracy of the connection status judgment to 100%, while preventing sealing failure caused by misoperation, and improving the system reliability by 90%.

[0048] As a preferred embodiment, the connecting surface of the rotating buckle 6 is provided with a groove, and the pipeline interface 4 and the column end interface 2 are locked by combining with the limiting rod 2043. After the column end interface 2 and the pipeline interface 4 are locked by the locking mechanism 204 and the rotating buckle 6, the rotating buckle 6 is moved forward by continuing to rotate, driving the limiting rod 2043 to move, and the protruding block 20431 is separated from the rotating buckle 6 by the telescopic spring 2044, so that the rotating buckle 6 rotates counterclockwise to disengage the slot 2042 and thereby releases the lock.

[0049] In a specific embodiment, the connecting surface of the rotating buckle 6 is designed with a precisely machined groove B to form an asymmetric matching relationship with the raised block 20431 of the limiting rod 2043. A 30° guide slope is set at the starting end of the groove B, and a mechanical limiting structure is provided at the end. The contact surface with the raised block 20431 is treated with tungsten carbide coating, and the hardness reaches HRA90 or above, ensuring that the wear amount is ≤0.01mm after 5000 operations; the limiting rod 2043 is connected to the inner wall of the limiting boss 2041 through a rotating shaft, and the rotation angle is designed to be 30°, which can provide 3-5N reset elastic force to ensure the stability of the locked state; the telescopic spring 2044 is made of SUS304 stainless steel, and the spring stiffness coefficient is 8N / mm, the initial compression amount is set to 1.5mm, and the thermal expansion displacement of ±0.3mm can be dynamically compensated; during operation, the rotating buckle 6 drives the limit rod 2043 to slide along the slot 2042, and the raised block 20431 contacts the inclined surface of the groove B to generate a normal force of 5-8N, so that the locking operation feels clear, and the operating force is controlled within the range of 3-5N, which is 50% lower than the traditional structure; the dual-state indication mark 2045 adopts laser engraving technology, and the "LOCK" and "UNLOCK" marks are engraved on the top of the limit boss 2041. With the visual indication window 14, the accuracy of connection status judgment is increased to 100%, while preventing sealing failure caused by misoperation, and improving system reliability by 90%;

[0050] The technical effect of this design is reflected in: the precise matching design of the connecting surface groove B of the rotating buckle 6 and the protruding block 20431 of the limiting rod 2043 improves the wear resistance of the locking mechanism 204 by 80%, and can still maintain a stable locking force after 10,000 operation cycles; the 30° rotation angle design of the limiting rod 2043 combined with the preload control of the telescopic spring 2044 controls the locking operation force within the range of 3-5N, which is 50% lower than the traditional structure, while preventing damage to parts caused by overload; the combined design of the dual-state indication mark 2045 and the visual indication window 14 increases the accuracy of connection status judgment to 100%, and operators can quickly master the use method without professional training, and the error rate is reduced by 95%; the protruding block 20431 with tungsten carbide coating improves the wear resistance by 80%, and the wear amount is ≤0.01mm after 5,000 operations, extending the service life and reducing the maintenance requirements by 90%.

[0051] As a preferred embodiment, a temperature sensor 16 is provided on one side of the internal pipe of the pipe interface 4, a grounding terminal 17 is provided on one side of the temperature sensor 16, and an insulating gasket 18 is provided on one side of the temperature sensor 16 and the grounding terminal 17, and the center of the insulating gasket 18 is combined with the pipe of the pipe interface 4.

[0052] In a specific implementation, the temperature sensor 16 is of model DS75LX of MAXI M Company, which is installed inside the pipeline interface 4 by adhesion to monitor the working temperature of the connector in real time. At the same time, a grounding terminal 17 made of copper alloy material is provided on one side by adhesion to release static electricity and protect the temperature sensor 16. At the same time, an insulating gasket 18 made of polyimide material is provided on one side of its surface. The insulating gasket 18 is consistent with the inner diameter of the pipeline interface 4 and is directly engaged. The insulating gasket 18 is used to isolate electrical components to prevent short circuits.

[0053] The working process of the present invention is as follows: the connector body of the column end interface 2 is made of 316L stainless steel precision casting, and the surface is electrolytically polished. The main seal is a V-ring 301 made of perfluoroether rubber material with a Shore hardness of 70±5 and a temperature resistance range of -20℃ to 150℃. The processing accuracy of the guide groove 13 is controlled within ±0.01mm. The rotating locking mechanism 204 compresses the titanium alloy torsion spring 10 to provide a locking torque of 8-10N·m, and then aligns the color standard positioning point 7. The axial insertion connector is rotated 60° clockwise to the first gear position, and the hand feels obvious "click" feedback. Continue to rotate 60° to the final locking position to make the composite sealing structure 3 seal. The sealing state of the internal composite sealing structure 3 is observed through the visual indicator window 14, and then the locking state of the locking mechanism is checked. After confirmation, the connection and locking are completed. The above is the working principle of this liquid chromatography column that is easy to connect.

Claims

1. A liquid chromatography column that is convenient to connect, comprising a liquid chromatography column (1), characterized in that: A column end interface (2) is provided on one side of the liquid chromatography column (1), a composite sealing structure (3) is provided on one side of the column end interface (2), a pipeline interface (4) is provided on one side of the composite sealing structure (3), the column end interface (2) comprises a sealing groove (201), a connecting pipeline (202), a guide pin (203) and a locking mechanism (204), a connecting pipeline (202) is provided at the center of the sealing groove (201), and a guide pin (203) is provided on one side of the outer wall of the sealing groove (201). A guide pin (203), a locking mechanism (204) is provided on one side of the guide pin (203), a wave spring (5) is provided on one side of the composite sealing structure (3), and the composite sealing structure (3) is connected to the pipeline interface (4) via the wave spring (5), a rotating buckle (6) is provided on one side of the outer wall of the pipeline interface (4), and the rotating buckle (6) locks the column end interface (2) and the pipeline interface (4) by combining with the locking mechanism (204).

2. A liquid chromatography column conveniently connected according to claim 1, characterized in that: A color mark positioning point (7) is provided on one side of the outer wall of the column end interface (2) and the pipeline interface (4), and a one-way spiral groove (8) is provided on one side of the sealing groove (201), and a spiral guide groove (9) is provided on one side of the inner wall of the pipeline interface (4). The column end interface (2) and the pipeline interface (4) are combined by aligning the color mark positioning points (7) of the column end interface (2) and the pipeline interface (4) and rotating the spiral guide groove (9) clockwise to connect with the one-way spiral groove (8).

3. The conveniently connected liquid chromatography column according to claim 1, characterized in that: The composite sealing structure (3) comprises a V-shaped ring (301), a sealing wedge-shaped pad (302) and a dust ring (303); one side of the wave spring (5) is fixedly connected to the inside of the sealing groove (201); the other side of the wave spring (5) is provided with a V-shaped ring (301); one side of the V-shaped ring (301) is provided with a sealing wedge-shaped pad (302); one side of the sealing wedge-shaped pad (302) is provided with a dust ring (303); by combining the column end interface (2) and the pipeline interface (4), the dust ring (303) drives the V-shaped ring (301) and the sealing wedge-shaped pad (302) to move, thereby compressing the wave spring (5).

4. The conveniently connected liquid chromatography column according to claim 3, characterized in that: A titanium alloy torsion spring (10) is arranged inside the pipeline interface (4), a sealing pressure ring (11) is arranged on one side of the titanium alloy torsion spring (10), the sealing pressure ring (11) has the same cross-sectional size as the dustproof ring (303), a fixing bolt (12) is arranged on one side of the sealing pressure ring (11), a guide groove (13) is arranged on one side of the fixing bolt (12), and the guide pin (203) is connected by rotating clockwise along the column end interface (2) through the pipeline interface (4), thereby being combined with the guide groove (13).

5. The conveniently connected liquid chromatography column according to claim 3, characterized in that: A visual indication window (14) is provided on one side of the outer wall of the composite sealing structure (3), an indication window dustproof ring (15) is provided on one side of the visual indication window (14), and the visual indication window (14) is connected to the pipeline interface (4) via the indication window dustproof ring (15).

6. The conveniently connected liquid chromatography column according to claim 1, characterized in that: The locking mechanism (204) comprises a limiting boss (2041), a slot (2042), a limiting rod (2043), a telescopic spring (2044) and an indication mark (2045); a slot (2042) is provided on one side of the limiting boss (2041); a limiting rod (2043) is provided inside the slot (2042); a protruding block (20431) is provided on the outer wall of the limiting rod (2043); one side of the limiting rod (2043) is connected to the inner wall of the limiting boss (2041) via a rotating shaft; a telescopic spring (2044) is provided on the other side of the limiting rod (2043); an indication mark (2045) is provided on the top of the limiting boss (2041); and an identification nameplate (19) is provided on one side of the limiting boss (2041).

7. The conveniently connected liquid chromatography column according to claim 6, characterized in that: The connection surface of the rotating buckle (6) is provided with a groove, and the pipeline interface (4) and the column end interface (2) are locked by combining with the limiting rod (2043). After the column end interface (2) and the pipeline interface (4) are locked by the locking mechanism (204) and the rotating buckle (6), the rotating buckle (6) is moved forward by continuing to rotate, driving the limiting rod (2043) to move, and the protruding block (20431) is separated from the rotating buckle (6) by the telescopic spring (2044), so that the rotating buckle (6) rotates counterclockwise to escape from the slot (2042), thereby releasing the lock.

8. The conveniently connected liquid chromatography column according to claim 1, characterized in that: A temperature sensor (16) is provided on one side of the internal pipe of the pipe interface (4), a grounding terminal (17) is provided on one side of the temperature sensor (16), and an insulating gasket (18) is provided on one side of the temperature sensor (16) and the grounding terminal (17), the center of the insulating gasket (18) being combined with the pipe of the pipe interface (4).

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