Anti-aging anti-oxidation composite additive for pets and preparation method of anti-aging anti-oxidation composite additive

Abstract

The invention relates to the technical field of pet additive treatment, in particular to an anti-oxidation composite additive for pet aging resistance and a preparation method thereof.The composite additive is prepared from, by mass, 60%-70% of natural antioxidant, 20%-30% of synergistic components and 20%-30% of functional auxiliary materials; 20-30% of a synergistic component; and 10-15% of functional auxiliary materials. The quercetin, the green tea extract, the L-carnitine and the Omega-3 are added into the additive, the quercetin has strong oxidation resistance and can slow down cell aging, the green tea extract is rich in tea polyphenol and catechin, and the tea polyphenol and the catechin can capture free radicals one by one, so that damage of the free radicals to the skin is relieved, the additive is beneficial to delaying skin aging, and the anti-aging effect is good. The L-carnitine and the Omega-3 have good effects of delaying senescence and resisting oxidation, and a plurality of anti-aging substances are added, so that the anti-aging process of pets can be delayed after the pet food is eaten by the pets, and the possibility of discarding the pets by feeders is reduced.

Description

Technical Field

[0001] The invention relates to the technical field of pet additive processing, in particular to an antioxidant composite additive for pet anti-aging and a preparation method thereof. Background Art

[0002] Pet feed refers to pet feed, also known as pet food. Initially, pet feed refers to high-end animal food specially supplied for pets, which is between human food and traditional livestock and poultry feed. Its main function is to provide pets with the most basic nutrients required for life guarantee, growth and health. Pet food has the advantages of comprehensive nutrition, high digestion and absorption rate, scientific formula, quality standards, easy feeding and prevention of certain diseases. A variety of additives can be added to pet feed to achieve different effects.

[0003] However, the nutritional additives in existing pet additives include vitamins, minerals and amino acids, etc. These additives are used to meet the nutritional needs of pets and promote their healthy growth. They are essential for the development of pets' bones and teeth. Additives such as preservatives, antioxidants and pigments are used to extend the shelf life of feed, maintain feed freshness and improve the appearance of feed. Additives such as enzyme preparations and probiotic preparations can improve the digestion ability of pets, help regulate the intestinal flora of pets, and promote digestion and absorption. There are no anti-aging pet feed additives on the market. Some humans who keep pets will always care about their pets' health and appearance. Pet aging will cause some owners to abandon their pets, leading to an increase in stray pets. Summary of the invention

[0004] The object of the present invention is to provide an antioxidant composite additive for anti-aging of pets and a preparation method thereof, so as to solve the problem mentioned in the above background technology that some pet owners abandon their pets after aging.

[0005] To achieve the above object, the present invention provides the following technical solution: an antioxidant composite additive for pet anti-aging and a preparation method thereof, comprising:

[0006] The basic components of the composite additive include natural antioxidants, synergistic enhancing ingredients and functional excipients, and the mass ratio of the natural antioxidants to the functional excipients is 60-70%; synergistic enhancing ingredients 20-30%; functional excipients 10-15%;

[0007] The natural antioxidants include curcumin, quercetin, green tea extract, astaxanthin and vitamin E, and the mass ratios of each other are curcumin 10-15%; quercetin 8-12%; green tea extract 5-8%; astaxanthin 3-5%; vitamin E 2-3%;

[0008] The synergistic ingredients include N-acetylcysteine, L-carnitine, taurine and Omega-3, with the mass ratio of N-acetylcysteine ​​5-8%; L-carnitine 4-6%; taurine 3-5%; Omega-3 5-10%;

[0009] The functional auxiliary materials include microcrystalline cellulose, yeast extract and silicon dioxide, and the mass ratio of the microcrystalline cellulose is 5-8%, the yeast extract is 3-5%, and the silicon dioxide is 1-2%.

[0010] Preferably, the preparation process of the antioxidant composite additive for pet anti-aging is as follows:

[0011] ① Preparation of curcumin: Select high-quality turmeric rhizomes as raw materials, wash, peel, slice, air or dry to obtain dried turmeric rhizomes, crush the dried turmeric rhizomes, put them into an extract tank, add an appropriate amount of organic solvents such as ethanol, methanol or ethyl acetate, and soak for 24 hours, during which time the appropriate temperature and stirring intensity are maintained to ensure that the solvent fully penetrates and dissolves the curcumin, filter the extracted solution through a medium such as a belt filter to remove impurities and solid particles, and obtain a relatively pure curcumin extract, remove most of the solvent by evaporation, and then further concentrate the solution using a concentration device to increase the curcumin content;

[0012] ② Preparation of quercetin: Select plant materials containing quercetin precursors, subject the raw materials to water extraction, extract rutin by alkali extraction and acid precipitation or organic solvent extraction, boil with 0.05% NaOH solution for 20 minutes, filter while hot, repeat 4 times to obtain an alkaline aqueous solution of rutin, then add acid to precipitate it, wash with water, dry to obtain rutin, dissolve the extracted rutin in 2% dilute sulfuric acid, react at 80-90° C. for 4 hours, stand for 4 hours after the reaction, perform vacuum filtration, wash the filter cake with distilled water until neutral, dry to obtain a crude quercetin product, and recrystallize the obtained crude quercetin product to obtain a yellow quercetin powder;

[0013] ③ Preparation of microcrystalline cellulose: Select suitable natural plant raw materials, wash and crush them to remove impurities, chemically or physically treat the raw materials to remove non-cellulose components and improve the purity of cellulose, react the purified cellulose with inorganic acid at a certain temperature and concentration, wash the hydrolyzed mixture, dry the washed microcrystalline cellulose, and crush the dried microcrystalline cellulose to obtain the desired particle size.

[0014] Preferably, the natural antioxidants include curcumin, quercetin, green tea extract, astaxanthin and vitamin E, and the mass ratios thereof are curcumin 10-15%; quercetin 8-12%; green tea extract 5-8%; astaxanthin 3-5%; and vitamin E 2-3%.

[0015] Preferably, the synergistic ingredients include N-acetylcysteine, L-carnitine, taurine and Omega-3, and the mass ratios thereof are 5-8% of N-acetylcysteine; 4-6% of L-carnitine; 3-5% of taurine; and 5-10% of Omega-3.

[0016] Preferably, the functional excipients include microcrystalline cellulose, yeast extract and silicon dioxide, and the mass ratios thereof are 5-8% microcrystalline cellulose, 3-5% yeast extract and 1-2% silicon dioxide.

[0017] Preferably, the green tea extract is an active ingredient extracted from green tea leaves, mainly including tea polyphenols, caffeine, aromatic oils, water, minerals, pigments, carbohydrates, proteins, amino acids, vitamins and the like.

[0018] Preferably, the L-carnitine is a special amino acid, a key substance in the fat metabolism process, and the Omega-3 is a group of polyunsaturated fatty acids, which are commonly found in deep-sea fish, seal oil, and certain plants. It is an indispensable unsaturated fatty acid and plays an important role in health.

[0019] Preferably, the yeast extract is a brown-yellow soluble paste or light yellow powder pure natural product obtained by degrading proteins, nucleic acids, etc. in yeast cells and then refining them using modern biological high-tech technologies such as autolysis, enzymolysis, separation, and concentration.

[0020] Compared with the prior art, the beneficial effects of the present invention are as follows: quercetin, green tea extract, L-carnitine and Omega-3 are added to the additive of the present invention; quercetin has a strong antioxidant capacity, can remove free radicals in the body, slow down cell aging, and protect cells from oxidative damage; green tea extract is rich in tea polyphenols and catechins, these two components can effectively remove free radicals; tea polyphenols and catechins can capture free radicals one by one, thereby reducing their damage to the skin, which not only helps to delay skin aging, but also reduces the dullness and aging of the skin caused by oxidative stress; L-carnitine and Omega-3 have very good effects on delaying aging and anti-oxidation; a variety of anti-aging substances are added, and after the pet eats, the aging process of the pet can be delayed, thereby reducing the possibility of the pet being abandoned by the owner. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] An embodiment provided by the present invention: an antioxidant composite additive for pet anti-aging and a preparation method thereof, comprising:

[0023] The basic components of the composite additive include natural antioxidants, synergistic enhancing ingredients and functional excipients, and the mass ratio of the natural antioxidants to the functional excipients is 60-70%; synergistic enhancing ingredients 20-30%; functional excipients 10-15%;

[0024] The natural antioxidants include curcumin, quercetin, green tea extract, astaxanthin and vitamin E, and the mass ratios of each other are curcumin 10-15%; quercetin 8-12%; green tea extract 5-8%; astaxanthin 3-5%; vitamin E 2-3%;

[0025] The synergistic ingredients include N-acetylcysteine, L-carnitine, taurine and Omega-3, with the mass ratio of N-acetylcysteine ​​5-8%; L-carnitine 4-6%; taurine 3-5%; Omega-3 5-10%;

[0026] The functional auxiliary materials include microcrystalline cellulose, yeast extract and silicon dioxide, and the mass ratio of the microcrystalline cellulose is 5-8%, the yeast extract is 3-5%, and the silicon dioxide is 1-2%.

[0027] Furthermore, the preparation process of the antioxidant composite additive for pet anti-aging is as follows:

[0028] ① Preparation of curcumin: Select high-quality turmeric rhizomes as raw materials, wash, peel, slice, air or dry to obtain dried turmeric rhizomes, crush the dried turmeric rhizomes, put them into an extract tank, add an appropriate amount of organic solvents such as ethanol, methanol or ethyl acetate, and soak for 24 hours, during which time the appropriate temperature and stirring intensity are maintained to ensure that the solvent fully penetrates and dissolves the curcumin, filter the extracted solution through a medium such as a belt filter to remove impurities and solid particles, and obtain a relatively pure curcumin extract, remove most of the solvent by evaporation, and then further concentrate the solution using a concentration device to increase the curcumin content;

[0029] ② Preparation of quercetin: Select plant materials containing quercetin precursors, subject the raw materials to water extraction, extract rutin by alkali extraction and acid precipitation or organic solvent extraction, boil with 0.05% NaOH solution for 20 minutes, filter while hot, repeat 4 times to obtain an alkaline aqueous solution of rutin, then add acid to precipitate it, wash with water, dry to obtain rutin, dissolve the extracted rutin in 2% dilute sulfuric acid, react at 80-90° C. for 4 hours, stand for 4 hours after the reaction, perform vacuum filtration, wash the filter cake with distilled water until neutral, dry to obtain a crude quercetin product, and recrystallize the obtained crude quercetin product to obtain a yellow quercetin powder;

[0030] ③ Preparation of microcrystalline cellulose: Select suitable natural plant raw materials, wash and crush them to remove impurities, chemically or physically treat the raw materials to remove non-cellulose components and improve the purity of cellulose, react the purified cellulose with inorganic acid at a certain temperature and concentration, wash the hydrolyzed mixture, dry the washed microcrystalline cellulose, and crush the dried microcrystalline cellulose to obtain the desired particle size.

[0031] Furthermore, the natural antioxidants include curcumin, quercetin, green tea extract, astaxanthin and vitamin E, and the mass ratios of each other are curcumin 10-15%; quercetin 8-12%; green tea extract 5-8%; astaxanthin 3-5%; vitamin E 2-3%. Curcumin has the effects of anti-oxidation, scavenging oxygen free radicals, protecting the liver and kidneys, etc., and has high anti-inflammatory activity and certain anti-inflammatory effects. Quercetin has the effects of lowering blood pressure, enhancing capillary resistance, reducing capillary fragility, lowering blood lipids, dilating coronary arteries, and increasing coronary blood flow, etc. It is used to treat chronic bronchitis and also has an auxiliary therapeutic effect on patients with coronary heart disease and hypertension.

[0032] Furthermore, the synergistic ingredients include N-acetylcysteine, L-carnitine, taurine and Omega-3, and the mass ratios between them are N-acetylcysteine ​​5-8%; L-carnitine 4-6%; taurine 3-5%; Omega-35-10%. N-acetylcysteine ​​can increase the secretion of serous glands in the respiratory mucosa and reduce the secretion of mucous glands, thereby reducing the viscosity of sputum and promoting its discharge.

[0033] Furthermore, the functional excipients include microcrystalline cellulose, yeast extract and silicon dioxide, and the mass ratio between them is 5-8% microcrystalline cellulose; 3-5% yeast extract; 1-2% silicon dioxide. Microcrystalline cellulose can increase satiety, improve digestive function, lower cholesterol, prevent diabetes or assist in weight loss, increase gastrointestinal motility, promote food digestion and absorption, thereby helping to improve digestive function, help bind cholesterol, excrete it from the intestine, assist in lowering cholesterol, and slow down the digestion and absorption of food in the gastrointestinal tract. Silicon dioxide plays a role in moisture-proof and anti-caking, preventing feed from spoiling.

[0034] Furthermore, green tea extract is an active ingredient extracted from green tea leaves, mainly including tea polyphenols, caffeine, aromatic oils, water, minerals, pigments, carbohydrates, proteins, amino acids, vitamins, etc. Green tea extract has antioxidant, cardiovascular disease risk reduction, anti-cancer, anti-inflammatory, metabolism promotion, oral health protection and other effects. It is rich in tea polyphenols and catechins and other ingredients, has strong antioxidant capacity, can remove free radicals in the body, reduce the damage of oxidative stress to the body, can reduce the oxidation of low-density lipoprotein cholesterol, increase the level of high-density lipoprotein cholesterol, improve vascular endothelial function, increase vascular elasticity, thereby reducing the risk of cardiovascular disease. The ingredients in green tea extract have anti-cancer properties, can inhibit the growth and spread of tumor cells, and induce tumor cell apoptosis.

[0035] Furthermore, L-carnitine is a special amino acid and a key substance in the process of fat metabolism. L-carnitine plays a key role in the process of fat metabolism. It can transport activated long-chain fatty acids from outside the mitochondrial membrane to inside the membrane, so that fatty acids can be smoothly β-oxidized, thereby releasing energy for the body to use. It can be used as a cardioprotectant to help maintain heart health. It also has a certain antioxidant effect. It can remove free radicals in the body and reduce cell damage, thereby delaying the aging process. It can lower blood cholesterol and triglyceride levels and help prevent the occurrence of hyperlipidemia and atherosclerosis. Omega-3 is a group of polyunsaturated fatty acids, commonly found in deep-sea fish, seal oil, and certain plants. It is an indispensable unsaturated fatty acid and plays an important role in physical health. Omega-3 has the effects of promoting cardiovascular health, anti-inflammatory effects, maintaining brain health, maintaining eye health, and regulating mental health.

[0036] Furthermore, yeast extract is a brown-yellow soluble paste or light yellow powdered pure natural product that is refined by degrading proteins, nucleic acids, etc. in yeast cells using modern biological high-tech technologies such as autolysis, enzymolysis, separation, and concentration. It can enhance immunity: the polysaccharides in yeast extract can stimulate the immune system, yeast extract can enhance the body's resistance to external pathogens, the B vitamins in yeast extract can help promote intestinal health, improve digestive function, and prevent constipation and diarrhea, the trace elements and amino acids in yeast extract can promote body metabolism and help maintain normal physiological functions, yeast extract is rich in protein and essential amino acids, providing the body with necessary nutrition, the antioxidant components in yeast extract help reduce the damage of free radicals to cells and protect cell health, yeast extract also has the functions of supplementing nutrition, promoting digestion, assisting in improving sleep quality, and assisting in lowering blood pressure.

[0037] Working principle:

[0038] Step 1: Raw material pretreatment

[0039] Nano-encapsulated curcumin: Curcumin and hydroxypropyl-β-cyclodextrin (HP-β-CD) were mixed in a mass ratio of 1:3, added to deionized water and stirred (40°C, 500 rpm) until completely dissolved, and spray-dried to obtain nanoparticles (particle size <200 nm);

[0040] EGCG decaffeination: using supercritical CO 2 The extraction method separates caffeine from green tea extract, retaining EGCG purity >90%.

[0041] Step 2: Dry Mixing

[0042] The pretreated curcumin, quercetin, EGCG, astaxanthin and vitamin E (spray-dried powder) were added to a three-dimensional motion mixer in proportion, and NAC, L-carnitine, taurine and Omega-3 microcapsule powder were added and mixed at a low speed for 20 minutes (humidity <30%, temperature <25°C).

[0043] Step 3: Granulation and stabilization

[0044] Fluidized bed granulation: Microcrystalline cellulose is used as the skeleton, and 5% hydroxypropyl methylcellulose (HPMC) aqueous solution is sprayed in as a binder to form uniform particles (particle size range 150-300μm).

[0045] Antioxidant coating: Vitamin E (0.5% ethanol solution) is sprayed on the surface of the particles using liposome encapsulation technology to prevent oxidative degradation.

[0046] Step 4: Seasoning and packaging

[0047] Yeast extract and silicon dioxide were mixed in proportion and mixed with the granules by a V-type mixer for 10 minutes;

[0048] Nitrogen filled sealed packaging in aluminum plastic composite bag (oxygen permeability <0.1cc / m 2 / day), store away from light.

[0049] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-restrictive in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention.

Claims

1. An antioxidant composite additive for pet anti-aging and a preparation method thereof, characterized in that: include, The basic components of the composite additive include natural antioxidants, synergistic enhancing ingredients and functional excipients, and the mass ratio of the natural antioxidants to the functional excipients is 60-70%; synergistic enhancing ingredients 20-30%; functional excipients 10-15%; The natural antioxidants include curcumin, quercetin, green tea extract, astaxanthin and vitamin E, and the mass ratios of each other are curcumin 10-15%; quercetin 8-12%; green tea extract 5-8%; astaxanthin 3-5%; vitamin E 2-3%; The synergistic ingredients include N-acetylcysteine, L-carnitine, taurine and Omega-3, with the mass ratio of N-acetylcysteine ​​5-8%; L-carnitine 4-6%; taurine 3-5%; Omega-3 5-10%; The functional auxiliary materials include microcrystalline cellulose, yeast extract and silicon dioxide, and the mass ratio of the microcrystalline cellulose is 5-8%, the yeast extract is 3-5%, and the silicon dioxide is 1-2%.

2. The anti-aging antioxidant composite additive for pets and its preparation method according to claim 1, characterized in that: The preparation process of the antioxidant composite additive for pet anti-aging is as follows: ① Preparation of curcumin: Select high-quality turmeric rhizomes as raw materials, wash, peel, slice, air or dry to obtain dried turmeric rhizomes, crush the dried turmeric rhizomes, put them into an extract tank, add an appropriate amount of organic solvents such as ethanol, methanol or ethyl acetate, and soak for 24 hours, during which time the appropriate temperature and stirring intensity are maintained to ensure that the solvent fully penetrates and dissolves the curcumin, filter the extracted solution through a medium such as a belt filter to remove impurities and solid particles, and obtain a relatively pure curcumin extract, remove most of the solvent by evaporation, and then further concentrate the solution using a concentration device to increase the curcumin content; ② Preparation of quercetin: Select plant materials containing quercetin precursors, subject the raw materials to water extraction, extract rutin by alkali extraction and acid precipitation or organic solvent extraction, boil with 0.05% NaOH solution for 20 minutes, filter while hot, repeat 4 times to obtain an alkaline aqueous solution of rutin, then add acid to precipitate it, wash with water, dry to obtain rutin, dissolve the extracted rutin in 2% dilute sulfuric acid, react at 80-90° C. for 4 hours, stand for 4 hours after the reaction, perform vacuum filtration, wash the filter cake with distilled water until neutral, dry to obtain a crude quercetin product, and recrystallize the obtained crude quercetin product to obtain a yellow quercetin powder; ③ Preparation of microcrystalline cellulose: Select suitable natural plant raw materials, wash and crush them to remove impurities, chemically or physically treat the raw materials to remove non-cellulose components and improve the purity of cellulose, react the purified cellulose with inorganic acid at a certain temperature and concentration, wash the hydrolyzed mixture, dry the washed microcrystalline cellulose, and crush the dried microcrystalline cellulose to obtain the desired particle size.

3. The anti-aging antioxidant composite additive for pets and its preparation method according to claim 1, characterized in that: The natural antioxidants include curcumin, quercetin, green tea extract, astaxanthin and vitamin E, and the mass ratios thereof are: curcumin 10-15%, quercetin 8-12%, green tea extract 5-8%, astaxanthin 3-5% and vitamin E 2-3%.

4. The anti-oxidation composite additive for pet anti-aging and the preparation method thereof according to claim 1, characterized in that: The synergistic enhancing ingredients include N-acetylcysteine, L-carnitine, taurine and Omega-3, and the mass ratios thereof are 5-8% of N-acetylcysteine, 4-6% of L-carnitine, 3-5% of taurine and 5-10% of Omega-3.

5. The anti-aging antioxidant composite additive for pets and its preparation method according to claim 2, characterized in that: The functional auxiliary materials include microcrystalline cellulose, yeast extract and silicon dioxide, and the mass ratio of the microcrystalline cellulose is 5-8%, the yeast extract is 3-5%, and the silicon dioxide is 1-2%.

6. The anti-aging antioxidant composite additive for pets and its preparation method according to claim 3, characterized in that: The green tea extract is an active ingredient extracted from green tea leaves, and mainly includes tea polyphenols, caffeine, aromatic oils, water, minerals, pigments, carbohydrates, proteins, amino acids, vitamins, and the like.

7. The anti-aging antioxidant composite additive for pets and its preparation method according to claim 4, characterized in that: The L-carnitine is a special amino acid and a key substance in the fat metabolism process. The Omega-3 is a group of polyunsaturated fatty acids, which are commonly found in deep-sea fish, seal oil, and certain plants. It is an indispensable unsaturated fatty acid and plays an important role in health.

8. The anti-aging antioxidant composite additive for pets and its preparation method according to claim 5, characterized in that: The yeast extract is a brown-yellow soluble paste or light yellow powder pure natural product obtained by degrading proteins, nucleic acids, etc. in yeast cells and refining them using modern biological high-tech technologies such as autolysis, enzymolysis, separation, and concentration.