Peptide-containing composition with function of improving qi and blood as well as preparation method and application of peptide-containing composition

Abstract

The invention belongs to the technical field of functional foods, and particularly relates to a peptide-containing composition with a function of improving qi and blood as well as a preparation method and application of the peptide-containing composition. The peptide-containing composition comprises ginseng oligopeptide, donkey-hide gelatin peptide, bovine blood peptide, wolfberry peptide, fish collagen peptide, American ginseng peptide, lily extract, licorice extract, sea buckthorn fruit powder, polydextrose and xanthan gum. According to the peptide-containing composition, a plurality of small-molecule active peptides are innovatively used as core components, and plant extracts, dietary fibers and fruit powder which have a synergistic effect are matched; the traditional Chinese medicine composition not only has advantages in absorption and utilization of components, but also is more comprehensive and deep in effect and action mechanism of improving qi and blood. Through the synergistic effect of a plurality of peptide components, generation of qi and blood can be promoted from a plurality of aspects, running of qi and blood can be regulated, meanwhile, immunity and oxidation resistance of the body are enhanced, and a more effective solution is provided for improving qi and blood.

Description

Technical Field

[0001] The invention belongs to the technical field of functional foods, and in particular relates to a peptide-containing composition capable of improving qi and blood functions, and a preparation method and application thereof. Background Art

[0002] Qi and blood are crucial concepts in traditional Chinese medicine and are the material basis for maintaining the normal functions of the body. Qi has the functions of promoting, warming, defending, consolidating and gasification, while blood has the function of nourishing and moisturizing the whole body. Qi can promote the circulation of blood, and blood can carry qi, and qi and blood nourish each other. Only when qi and blood are sufficient and run smoothly can the human body maintain a healthy state; on the contrary, insufficient qi and blood or disordered circulation will cause many diseases, such as pale complexion, dizziness, palpitations, insomnia, fatigue, etc., which seriously affect people's quality of life and physical health.

[0003] The main reasons for insufficient Qi and blood are as follows: In terms of Qi, dysfunction of the lung's function of controlling Qi, abnormal spleen and stomach transportation and transformation, and decreased kidney's function of controlling Qi will lead to insufficient Qi production; excessive fatigue and long-term illness will lead to excessive Qi consumption. In terms of blood, spleen and stomach weakness cannot provide sufficient raw materials for hematopoiesis, kidney essence deficiency leads to decreased bone marrow hematopoietic function, and insufficient lung Qi affects blood transfusion, leading to insufficient blood production; blood loss and blood stasis will lead to excessive blood consumption or loss, and blood stasis will hinder the production of new blood and further consume Qi and blood; lack of iron necessary for hematopoiesis and various proteins, sugars, and vitamins that assist hematopoiesis will lead to anemia.

[0004] The current functional foods for replenishing qi and blood are mainly single-function and have limited absorption. For example, patent CN118947913A provides an iron-rich composition with the function of replenishing qi and blood and a preparation method thereof, comprising the following raw materials in parts by weight: 0.05-0.1 parts of ferrous fumarate, 15-20 parts of hemoprotein polypeptides, 1-3 parts of ferrous gluconate, 8-13 parts of soybean polysaccharides, 25-30 parts of xylitol, 5-12 parts of red ginseng extract, 8-13 parts of polygonatum powder, 2-29 parts of wolfberry powder, 0.3-1 parts of acerola powder, 0.1-1 parts of lotus seed powder, and 0.3-2 parts of fish maw oligopeptide. The composition can improve the absorption of iron, while promoting the formation of red blood cells and hemoglobin, and synergistically improving the blood-replenishing effect. However, the ferrous fumarate and ferrous gluconate therein are easily affected by tannic acid, carbonate, cellulose and oxidative substances in food, resulting in limited absorption. Patent CN110420313A provides a donkey-hide gelatin and ginseng drink with the function of replenishing qi and blood, and its ingredients are: donkey-hide gelatin, red ginseng, American ginseng, northern astragalus, angelica, Cistanche deserticola, polygonatum, northern schisandra, cassia twig, raw rehmannia root, longan pulp, licorice, red dates, honey, fish scale collagen powder, sodium cyclamate, sterilized water. However, the formula contains as many as 17 ingredients, and too many ingredients may increase the risk of adverse reactions between them. At the same time, it lacks clear targeting and it is difficult to highlight the advantages of the product in specific functions.

[0005] Therefore, with a variety of small molecule active peptides as the core ingredients, combined with synergistic plant extracts, dietary fiber and fruit powder, a peptide-containing composition is provided that not only has advantages in the absorption and utilization of ingredients, but also is more comprehensive and in-depth in the effect and mechanism of action of improving qi and blood. Through the synergistic effect of various peptide ingredients, it promotes the generation of qi and blood and regulates the circulation of qi and blood from multiple levels, while enhancing the body's immunity and antioxidant capacity, which can provide a more effective solution for improving qi and blood. Summary of the invention

[0006] In view of the above-mentioned deficiencies, the present invention provides a peptide-containing composition having the function of improving qi and blood, and a preparation method and application thereof. The peptide-containing composition of the present invention includes: ginseng oligopeptides, donkey-hide gelatin peptides, bovine blood peptides, wolfberry peptides, fish collagen peptides, American ginseng peptides, lily extracts, licorice extracts, sea buckthorn fruit powder, polydextrose and xanthan gum. The peptide-containing composition innovatively uses a variety of small molecule active peptides as core ingredients, and is matched with synergistic plant extracts, dietary fiber and fruit powder; it not only has advantages in the absorption and utilization of ingredients, but also is more comprehensive and in-depth in the effect and mechanism of action of improving qi and blood. Through the synergistic effect of a variety of peptide ingredients, it can promote the generation of qi and blood and regulate the circulation of qi and blood from multiple levels, while enhancing the body's immunity and antioxidant capacity, providing a more effective solution for improving qi and blood.

[0007] The technical solution of the present invention is: On the one hand, the present invention provides a peptide-containing composition with the function of improving qi and blood, wherein the peptide-containing composition includes ginseng oligopeptide, donkey-hide gelatin peptide, bovine blood peptide, wolfberry peptide, fish collagen peptide, American ginseng peptide, lily extract, licorice extract, sea buckthorn fruit powder, polydextrose and xanthan gum.

[0008] Specifically, the peptide-containing composition includes, by weight: 10-25 parts of ginseng oligopeptides, 15-30 parts of donkey-hide gelatin peptides, 8-18 parts of bovine blood peptides, 10-20 parts of wolfberry peptides, 8-15 parts of fish collagen peptides, 5-12 parts of American ginseng peptides, 3-8 parts of lily extracts, 1-5 parts of licorice extracts, 5-12 parts of sea buckthorn fruit powder, 3-10 parts of polydextrose and 1-5 parts of xanthan gum.

[0009] Preferably, the peptide-containing composition comprises, by weight: 10-11 parts, 11-12 parts, 12-13 parts, 13-14 parts, 14-15 parts, 15-16 parts, 16-17 parts, 17-18 parts, 18-19 parts, 19-20 parts, 20-21 parts, 21-22 parts, 22-23 parts, 23-24 parts or 24-25 parts of ginseng oligopeptides.

[0010] Further preferably, the peptide-containing composition comprises, by weight, 12-13 parts, 13-14 parts, 14-15 parts, 15-16 parts, 16-17 parts or 17-18 parts of ginseng oligopeptides.

[0011] Still more preferably, the peptide-containing composition comprises, by weight: 15 parts of ginseng oligopeptides.

[0012] Preferably, the peptide-containing composition comprises, by weight, 15-16, 16-17, 17-18, 18-19, 19-20, 20-21, 21-22, 22-23, 23-24, 24-25, 25-26, 26-27, 27-28, 28-29 or 29-30 parts of donkey-hide gelatin.

[0013] Further preferably, the peptide-containing composition comprises, by weight, 18-19 parts, 19-20 parts, 20-21 parts, 21-22 parts, 22-23 parts, 23-24 parts or 24-25 parts of donkey-hide gelatin peptide.

[0014] Still more preferably, the peptide-containing composition comprises, by weight: 20 parts of donkey-hide gelatin peptide.

[0015] Preferably, the peptide-containing composition comprises, by weight, 8-9 parts, 9-10 parts, 10-11 parts, 11-12 parts, 12-13 parts, 13-14 parts, 14-15 parts, 15-16 parts, 16-17 parts or 17-18 parts of bovine blood peptides.

[0016] Further preferably, the peptide-containing composition comprises, by weight, 10-11 parts, 11-12 parts, 12-13 parts, 13-14 parts or 14-15 parts of bovine blood peptides.

[0017] Still more preferably, the peptide-containing composition comprises, by weight: 12 parts of bovine blood peptides.

[0018] Preferably, the peptide-containing composition comprises, by weight: 10-11 parts, 11-12 parts, 12-13 parts, 13-14 parts, 14-15 parts, 15-16 parts, 16-17 parts, 17-18 parts, 18-19 parts or 19-20 parts of wolfberry peptides.

[0019] Further preferably, the peptide-containing composition comprises, by weight, 12-13 parts, 13-14 parts, 14-15 parts or 15-16 parts of wolfberry peptides.

[0020] Still more preferably, the peptide-containing composition comprises, by weight: 15 parts of wolfberry peptides.

[0021] Preferably, the peptide-containing composition comprises, by weight: 8-9 parts, 9-10 parts, 10-11 parts, 11-12 parts, 12-13 parts, 13-14 parts or 14-15 parts of fish collagen peptides.

[0022] Further preferably, the peptide-containing composition comprises, by weight, 9-10 parts, 10-11 parts or 11-12 parts of fish collagen peptides.

[0023] Still more preferably, the peptide-containing composition comprises, by weight: 10 parts of fish collagen peptides.

[0024] Preferably, the peptide-containing composition comprises, by weight, 5-6 parts, 6-7 parts, 7-8 parts, 8-9 parts, 9-10 parts, 10-11 parts or 11-12 parts of American ginseng peptides.

[0025] Further preferably, the peptide-containing composition comprises, by weight, 6-7 parts, 7-8 parts, 8-9 parts or 9-10 parts of American ginseng peptides.

[0026] Still more preferably, the peptide-containing composition comprises, by weight: 8 parts of American ginseng peptides.

[0027] Preferably, the peptide-containing composition comprises, by weight, 3-4 parts, 4-5 parts, 5-6 parts, 6-7 parts or 7-8 parts of lily extract.

[0028] Further preferably, the peptide-containing composition comprises, by weight, 4-5 parts or 5-6 parts of lily extract.

[0029] Still more preferably, the peptide-containing composition comprises, by weight: 5 parts of lily extract.

[0030] Preferably, the peptide-containing composition comprises, by weight, 1-2 parts, 2-3 parts, 3-4 parts or 4-5 parts of licorice extract.

[0031] Further preferably, the peptide-containing composition comprises, by weight, 2-3 parts or 3-4 parts of licorice extract.

[0032] Still more preferably, the peptide-containing composition comprises, by weight: 2 parts of licorice extract.

[0033] Preferably, the peptide-containing composition comprises, by weight, 5-6 parts, 6-7 parts, 7-8 parts, 8-9 parts, 9-10 parts, 10-11 parts or 11-12 parts of sea buckthorn fruit powder.

[0034] Further preferably, the peptide-containing composition comprises, by weight, 6-7 parts, 7-8 parts, 8-9 parts or 9-10 parts of sea buckthorn fruit powder.

[0035] Still more preferably, the peptide-containing composition comprises, by weight: 7 parts of seabuckthorn fruit powder.

[0036] Preferably, the peptide-containing composition comprises, by weight, 3-4 parts, 4-5 parts, 5-6 parts, 6-7 parts, 7-8 parts, 8-9 parts or 9-10 parts of polydextrose.

[0037] Further preferably, the peptide-containing composition comprises 4-5 parts, 5-6 parts, 6-7 parts or 7-8 parts of polydextrose by weight.

[0038] Still more preferably, the peptide-containing composition comprises, by weight: 6 parts of polydextrose.

[0039] Preferably, the peptide-containing composition comprises, by weight, 1-2 parts, 2-3 parts, 3-4 parts or 4-5 parts of xanthan gum.

[0040] Further preferably, the peptide-containing composition comprises, by weight, 2-3 parts or 3-4 parts of xanthan gum.

[0041] Still more preferably, the peptide-containing composition comprises, by weight: 2 parts of xanthan gum.

[0042] In another aspect, the present invention provides a method for preparing any of the above peptide-containing compositions.

[0043] Preferably, the preparation method comprises: mixing ginseng oligopeptides, donkey-hide gelatin peptides, bovine blood peptides, wolfberry peptides, fish collagen peptides, American ginseng peptides, lily extracts, licorice extracts, seabuckthorn fruit powder, polydextrose and xanthan gum in proportion to obtain the peptide-containing composition.

[0044] In another aspect, the present invention provides the use of any of the above peptide-containing compositions in the preparation of products for improving qi and blood function, relieving fatigue, and enhancing immunity.

[0045] Preferably, the product comprises any one or more of functional food, health care product and medicine.

[0046] In yet another aspect, the present invention provides a functional food, comprising any one of the above peptide-containing compositions.

[0047] Specifically, the dosage form of the functional food includes: solid dosage form, semi-solid dosage form or liquid dosage form.

[0048] Preferably, the functional food includes: candy, soy milk, yogurt, canned food, biscuits, chocolate, cakes, cream, cheese, milk powder, formula milk powder, ice cream, jam, puree, candied fruit, preserved fruit, bread, egg rolls, protein drinks, solid drinks, lactic acid bacteria drinks, plant protein drinks, carbonated drinks, coffee or puffed food.

[0049] Preferably, the functional food comprises human food or animal food.

[0050] Specifically, the functional food also includes nutritionally acceptable nutrients.

[0051] Preferably, the nutrients include any one or more of dietary fiber, polypeptides, medicinal and edible raw materials, proteins, lipids, minerals, and vitamins.

[0052] Specifically, the functional food also includes food-acceptable auxiliary materials.

[0053] Preferably, the auxiliary materials include: any one or a combination of two or more of wetting agents, emulsifiers, preservatives, antioxidants, buffers, diluents, lubricants, solvents, suspending agents, solubilizers, thickeners, stabilizers, sweeteners and flavors.

[0054] Preferably, the functional food is used to improve qi and blood function, relieve fatigue or enhance immunity.

[0055] In yet another aspect, the present invention provides a health product, comprising any one of the above-mentioned peptide-containing compositions.

[0056] Specifically, the dosage forms of the health care products include: solid dosage forms, semi-solid dosage forms and liquid dosage forms.

[0057] Preferably, the dosage form of the health care product includes tablets, capsules, soft capsules, granules, pills, gel candies, powders, oral liquids or drops.

[0058] Specifically, the health care products also include nutritionally acceptable nutrients.

[0059] Preferably, the nutrients include one or more of dietary fiber, polypeptides, medicinal and edible raw materials, proteins, lipids, minerals, and vitamins.

[0060] Specifically, the health care product also includes auxiliary materials acceptable to health care products.

[0061] Preferably, the auxiliary materials include: one or a combination of two or more of wetting agents, emulsifiers, preservatives, antioxidants, buffers, diluents, lubricants, solvents, suspending agents, solubilizers, thickeners, stabilizers, sweeteners and flavors.

[0062] Preferably, the health care product is used to improve qi and blood function, relieve fatigue or enhance immunity.

[0063] In yet another aspect, the present invention provides a medicine comprising any one of the above-mentioned peptide-containing combinations.

[0064] Specifically, the dosage forms of the medicine include: tablets, pills, powders, suspensions, gels, emulsions, creams, granules, capsules, suppositories, injections, sprays or injections.

[0065] Specifically, the medicine also includes any one or more pharmaceutically acceptable excipients.

[0066] Preferably, the pharmaceutically acceptable excipients include: one or a combination of two or more of wetting agents, emulsifiers, preservatives, antioxidants, buffers, diluents, lubricants, solvents, suspending agents, solubilizers, thickeners, stabilizers, sweeteners and flavors.

[0067] Preferably, the medicine is used to prevent or treat qi and blood deficiency, prevent or treat iron deficiency anemia, relieve fatigue or enhance immunity.

[0068] In yet another aspect, the present invention provides an application of the functional food, health product or medicine, which comprises administering an effective amount of the functional food, health product or medicine to a subject.

[0069] Specifically, the subject is a mammal.

[0070] Preferably, the subject is a human.

[0071] In another aspect, the present invention provides a method for preventing or treating Qi and blood deficiency, preventing or treating iron deficiency anemia, improving Qi and blood function, relieving fatigue or enhancing immunity.

[0072] Specifically, the method comprises administering an effective amount of functional food, health product or medicine to the subject.

[0073] Preferably, the subject is a mammal.

[0074] More preferably, the subject is a human.

[0075] The beneficial effects of the present invention are: (1) The formula of the peptide composition of the present invention that improves the function of qi and blood is added with small molecule peptides that have the effects of tonifying the spleen and replenishing qi, nourishing the liver and kidneys, replenishing iron, and supplementing collagen. It not only has advantages in the absorption and utilization of ingredients, but also has a more comprehensive and in-depth effect and mechanism of action in improving qi and blood. Through the synergistic effect of multiple peptide components, it can promote the generation of qi and blood and regulate the circulation of qi and blood from multiple levels, while enhancing the body's immunity and improving the body's antioxidant capacity, providing a more effective solution for improving qi and blood.

[0076] (2) The peptide composition of the present invention has a formula for improving qi and blood function, and is added with lily extract and licorice extract, both of which are medicinal and edible raw materials. They will not cause any harm to the organs and tissues of the body, and can nourish the lung qi, promote the circulation of qi and blood, regulate qi and activate blood circulation, promote the circulation of blood, and play a role in nourishing without stagnation.

[0077] (3) The peptide-containing composition of the present invention has a formula for improving the function of qi and blood. The addition of polydextrose can regulate the intestinal flora, promote the intestinal absorption of other components, provide sufficient raw materials for the production of qi and blood, and thus improve the condition of insufficient qi and blood.

[0078] (4) The peptide-containing composition of the present invention has a formula for improving the function of qi and blood. The addition of xanthan gum can enhance the taste of the product, improve the stability of the product, and increase the acceptance of the product.

[0079] (5) The present invention has a formula of a peptide-containing composition that improves the function of qi and blood. The various functional ingredients added interact with each other to achieve the effect of regulating qi and blood and improving fatigue. Combined with the action mechanism of various functional ingredients, the peptides are scientifically and rationally matched for the purpose of replenishing qi and blood, resisting fatigue, and replenishing iron, thereby maximizing the efficacy of the peptides and solving the problem of improving qi and blood in an all-round way. At the same time, animal blood-replenishing experiments show that the peptide-containing composition for improving qi and blood of the present invention can effectively replenish blood and improve qi and blood within the preferred range. Reduction, replacement of components, and adjustment of the ratio outside the preferred range cannot achieve the effect of significantly replenishing blood and improving qi and blood. DETAILED DESCRIPTION

[0080] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution of the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0081] When the embodiments give numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any value between the two endpoints can be selected. Unless otherwise defined, the technical terms or scientific terms used herein should be the common meanings understood by people with ordinary skills in the field to which the present invention belongs.

[0082] It should be noted that the ginseng oligopeptide (20240618-1), donkey-hide gelatin peptide (20241223-3), bovine blood peptide (20240803-3), wolfberry peptide (20240127-1), fish collagen peptide (20241105-2), and American ginseng peptide (20240411-3) used in the present invention are all purchased from Anhui Shengmino Biotechnology Co., Ltd.; lily extract and licorice extract are purchased from Shaanxi Xintianyu Biotechnology Co., Ltd.; xanthan gum is purchased from Zibo Zhongxuan Biochemical Co., Ltd., and the remaining raw materials are all common commercially available products, and their sources are not specifically limited.

[0083] Example 1 The peptide-containing composition of Example 1 comprises, by weight: 10 parts of ginseng oligopeptides, 15 parts of donkey-hide gelatin peptides, 8 parts of bovine blood peptides, 18 parts of wolfberry peptides, 12 parts of fish collagen peptides, 10 parts of American ginseng peptides, 8 parts of lily extracts, 5 parts of licorice extracts, 12 parts of sea buckthorn fruit powder, 3 parts of polydextrose and 1 part of xanthan gum.

[0084] The preparation method of the peptide-containing composition of Example 1 is as follows: ginseng oligopeptide, donkey-hide gelatin peptide, bovine blood peptide, wolfberry peptide, fish collagen peptide, American ginseng peptide, lily extract, licorice extract, sea buckthorn fruit powder, polydextrose and xanthan gum are mixed according to weight parts.

[0085] Example 2 The peptide-containing composition of Example 2 includes, by weight: 15 parts of ginseng oligopeptide, 20 parts of donkey-hide gelatin peptide, 12 parts of bovine blood peptide, 15 parts of wolfberry peptide, 10 parts of fish collagen peptide, 8 parts of American ginseng peptide, 5 parts of lily extract, 2 parts of licorice extract, 7 parts of sea buckthorn fruit powder, 6 parts of polydextrose and 2 parts of xanthan gum.

[0086] The preparation method of the peptide-containing composition of Example 2 is the same as that of Example 1.

[0087] Example 3 The peptide-containing composition of Example 3 includes, by weight: 20 parts of ginseng oligopeptides, 25 parts of donkey-hide gelatin peptides, 15 parts of bovine blood peptides, 10 parts of wolfberry peptides, 8 parts of fish collagen peptides, 5 parts of American ginseng peptides, 3 parts of lily extracts, 1 part of licorice extract, 5 parts of sea buckthorn fruit powder, 8 parts of polydextrose and 3 parts of xanthan gum.

[0088] The preparation method of the peptide-containing composition of Example 3 is the same as that of Example 1.

[0089] Example 4 The peptide-containing composition of Example 4 includes, by weight: 25 parts of ginseng oligopeptide, 30 parts of donkey-hide gelatin peptide, 18 parts of bovine blood peptide, 20 parts of wolfberry peptide, 15 parts of fish collagen peptide, 12 parts of American ginseng peptide, 6 parts of lily extract, 3 parts of licorice extract, 10 parts of sea buckthorn fruit powder, 10 parts of polydextrose and 5 parts of xanthan gum.

[0090] The preparation method of the peptide-containing composition of Example 4 is the same as that of Example 1.

[0091] Comparative Example 1 The peptide-containing composition of Comparative Example 1 is different from that of Example 1 only in that bovine blood peptide and wolfberry peptide are not added.

[0092] The preparation method of the peptide-containing composition of Comparative Example 1 is as follows: ginseng oligopeptide, donkey-hide gelatin peptide, fish collagen peptide, American ginseng peptide, lily extract, licorice extract, seabuckthorn fruit powder, polydextrose and xanthan gum are mixed according to weight parts.

[0093] Comparative Example 2 The peptide-containing composition of Comparative Example 2 is different from that of Example 1 only in that lily extract and licorice extract are not added.

[0094] The preparation method of the peptide-containing composition of Comparative Example 2 is as follows: ginseng oligopeptide, donkey-hide gelatin peptide, bovine blood peptide, wolfberry peptide, fish collagen peptide, American ginseng peptide, sea buckthorn fruit powder, polydextrose and xanthan gum are mixed according to weight parts.

[0095] Comparative Example 3 The peptide-containing composition of Comparative Example 3 is different from that of Example 1 only in that no seabuckthorn fruit powder, polydextrose and xanthan gum are added.

[0096] The preparation method of the peptide-containing composition of Comparative Example 3 is as follows: ginseng oligopeptide, donkey-hide gelatin peptide, bovine blood peptide, wolfberry peptide, fish collagen peptide, American ginseng peptide, lily extract and licorice extract are mixed according to weight parts.

[0097] Comparative Example 4 The peptide-containing composition of Comparative Example 4 is different from that of Example 1 only in that the donkey-hide gelatin peptide is replaced by soybean peptide.

[0098] The preparation method of the peptide-containing composition of Comparative Example 4 is as follows: ginseng oligopeptide, soybean peptide, bovine blood peptide, wolfberry peptide, fish collagen peptide, American ginseng peptide, lily extract, licorice extract, sea buckthorn fruit powder, polydextrose and xanthan gum are mixed according to weight parts.

[0099] Comparative Example 5 The peptide-containing composition of Comparative Example 5 consists, by weight, of 10 parts of ginseng oligopeptide, 20 parts of donkey-hide gelatin peptide, 20 parts of bovine blood peptide, 25 parts of wolfberry peptide, 6 parts of fish collagen peptide, 4 parts of American ginseng peptide, 9 parts of lily extract, 6 parts of licorice extract, 15 parts of sea buckthorn fruit powder, 2 parts of polydextrose and 6 parts of xanthan gum.

[0100] The preparation method of the peptide-containing composition of Comparative Example 5 refers to Example 1.

[0101] Experimental Example 1 Blood-enriching effect test 110 healthy male SD rats, weighing 180-220g, of which 10 rats were given normal basal feed and normal drinking water as the normal control group. In addition to the normal control group, the remaining 100 rats were divided into 10 groups (model control group, Example 1-Example 4 group, Comparative Example 1-Comparative Example 5 group), 10 rats in each group, and intraperitoneally injected with 80 mg / kg of cyclophosphamide for 3 consecutive days to establish an anemia model. Blood was taken from the rat's eye socket to measure the hemoglobin (Hb) content. If Hb was lower than 110g / L, it was an anemic rat that was successfully modeled.

[0102] After the anemia model was established, the peptide-containing compositions of Examples 1 to 4 and Comparative Examples 1 to 5 were administered by gavage, respectively (prepared as solutions with normal saline), at a dose of 10 mL / kg, once a day, for 28 consecutive days. Rats in the normal control group and the model control group were administered by gavage with an equal volume of normal saline.

[0103] Routine blood test: 28 days after administration, blood was collected from the rats' orbits under light ether anesthesia, and the red blood cell count (RBC), hemoglobin content (Hb), and hematocrit (HCT) were measured using a blood cell analyzer.

[0104] Data processing: The experimental data were expressed as mean ± standard deviation (x ± s), and SPSS statistical software was used to analyze the data. Variance analysis was used to compare the significant differences between the data, and the significance level used was 95% (p < 0.05).

[0105] Test results: The hemoglobin content of rats in each group before administration is shown in Table 1; the hemoglobin content, red blood cell count and hematocrit index of rats in each group after 28 days of administration are shown in Table 2; different lowercase letters in the table represent significant differences between the groups (p<0.05).

[0106] Table 1 Hemoglobin content of rats in each group before administration

[0107] Table 2 Hemoglobin content, red blood cell count and hematocrit of rats in each group after administration

[0108] The results showed that after administration of the peptide-containing compositions of Examples 1 to 4, the number of red blood cells (RBC), hemoglobin content (Hb) and hematocrit (HCT) in the blood of anemic rats were significantly increased, indicating that the peptide-containing compositions of Examples 1 to 4 of the present invention can achieve a good blood-enriching effect.

[0109] Comparative Examples 1 to 3 lack 2 or 3 necessary components respectively, and Comparative Example 4 replaces donkey-hide gelatin peptide with soybean peptide, and its blood-enriching effect decreases to varying degrees. It shows that the peptide-containing composition of the present invention lacks one or more of the components, and the technical effect will deteriorate. It is worth noting that the Hb content of Comparative Examples 1 to 3 increased by 12.84 g / L, 28.07 g / L, and 43.16 g / L respectively compared with the model control group, while the Hb content of Example 1 increased by 90.86 g / L compared with the model control group. The peptide-containing composition of the present invention combines bovine blood peptide, wolfberry peptide, lily extract, licorice extract, sea buckthorn fruit powder, polydextrose and xanthan gum, which has a synergistic effect (90.86>12.84+28.07+43.16).

[0110] Comparative Example 5 changes the dosage of some components in Example 1, indicating that the best blood-enriching effect can be achieved only under the specific dosage of the present invention.

[0111] The above detailed description is a specific description of one of the feasible embodiments of the present invention, and the embodiment is not intended to limit the scope of the present invention. It should be pointed out that any equivalent implementation or change that does not deviate from the present invention should be included in the scope of the technical solution of the present invention. Therefore, the protection scope of the patent of the present invention shall be based on the attached requirements.

Claims

1. A peptide-containing composition having the function of improving qi and blood, characterized in that: The peptide-containing composition comprises ginseng oligopeptide, donkey-hide gelatin peptide, bovine blood peptide, wolfberry peptide, fish collagen peptide, American ginseng peptide, lily extract, licorice extract, seabuckthorn fruit powder, polydextrose and xanthan gum; The peptide-containing composition comprises, by weight: 10-25 parts of ginseng oligopeptides, 15-30 parts of donkey-hide gelatin peptides, 8-18 parts of bovine blood peptides, 10-20 parts of wolfberry peptides, 8-15 parts of fish collagen peptides, 5-12 parts of American ginseng peptides, 3-8 parts of lily extracts, 1-5 parts of licorice extracts, 5-12 parts of sea buckthorn fruit powder, 3-10 parts of polydextrose and 1-5 parts of xanthan gum.

2. The peptide-containing composition according to claim 1, characterized in that The peptide-containing composition comprises, by weight: 12-18 parts of ginseng oligopeptides, 18-25 parts of donkey-hide gelatin peptides, 10-15 parts of bovine blood peptides, 12-16 parts of wolfberry peptides, 9-12 parts of fish collagen peptides, 6-10 parts of American ginseng peptides, 4-6 parts of lily extracts, 2-4 parts of licorice extracts, 6-10 parts of sea buckthorn fruit powder, 4-8 parts of polydextrose and 2-4 parts of xanthan gum.

3. The peptide-containing composition according to claim 2, characterized in that The peptide-containing composition comprises, by weight: 15 parts of ginseng oligopeptide, 20 parts of donkey-hide gelatin peptide, 12 parts of bovine blood peptide, 15 parts of wolfberry peptide, 10 parts of fish collagen peptide, 8 parts of American ginseng peptide, 5 parts of lily extract, 2 parts of licorice extract, 7 parts of sea buckthorn fruit powder, 6 parts of polydextrose and 2 parts of xanthan gum.

4. The method for preparing the peptide-containing composition according to any one of claims 1 to 3, characterized in that: The preparation method comprises: mixing ginseng oligopeptide, donkey-hide gelatin peptide, bovine blood peptide, wolfberry peptide, fish collagen peptide, American ginseng peptide, lily extract, licorice extract, seabuckthorn fruit powder, polydextrose and xanthan gum in proportion to obtain the peptide-containing composition.

5. Use of the peptide-containing composition according to any one of claims 1 to 3 in the preparation of products for improving qi and blood function, relieving fatigue or enhancing immunity.

6. The use according to claim 5, characterized in that: The products include any one or more of functional foods, health products and medicines.

7. A functional food or health product, characterized in that: The functional food or health product comprises the peptide-containing composition according to any one of claims 1 to 3.

8. The functional food or health product according to claim 7, characterized in that: The dosage forms of the functional food or health product include: solid dosage form, semi-solid dosage form or liquid dosage form.

9. The functional food or health product according to claim 7, characterized in that: The functional food or health product also includes nutritionally acceptable nutrients.

10. The functional food or health product according to claim 9, characterized in that: The nutrients include any one or more of dietary fiber, polypeptides, medicinal and edible raw materials, proteins, lipids, minerals and vitamins.

11. The functional food or health product according to claim 7, characterized in that: The functional food or health product also includes auxiliary materials acceptable to food or health product.

12. The functional food or health product according to claim 11, characterized in that: The auxiliary materials include: any one or a combination of two or more of wetting agents, emulsifiers, preservatives, antioxidants, buffers, diluents, lubricants, solvents, suspending agents, solubilizers, thickeners, stabilizers, sweeteners and spices.

13. The functional food or health product according to claim 7, characterized in that: The functional food or health product is used to improve qi and blood function, relieve fatigue or enhance immunity.

14. A medicine, characterized in that: The medicine comprises the peptide-containing composition according to any one of claims 1 to 3.

15. The medicine according to claim 14, characterized in that The dosage forms of the medicine include: tablets, pills, powders, suspensions, gels, emulsions, creams, granules, capsules, suppositories, injections, sprays or injections.

16. The drug according to claim 15, characterized in that The medicine also includes any one or more pharmaceutically acceptable excipients.

17. The medicine according to claim 14, characterized in that The medicine is used for preventing or treating qi and blood deficiency, preventing or treating iron deficiency anemia, relieving fatigue or enhancing immunity.

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